nicotinamide 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
nicotinic acid or nicotinoyl alcohol derivatives 1906 98-92-0

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • niacinamide
  • nicotinamide
  • 3-pyridinecarboxamide
An important compound functioning as a component of the coenzyme NAD. Its primary significance is in the prevention and/or cure of blacktongue and PELLAGRA. Most animals cannot manufacture this compound in amounts sufficient to prevent nutritional deficiency and it therefore must be supplemented through dietary intake.
  • Molecular weight: 122.13
  • Formula: C6H6N2O
  • CLOGP: -0.21
  • LIPINSKI: 0
  • HAC: 3
  • HDO: 1
  • TPSA: 55.98
  • ALOGS: -0.39
  • ROTB: 1
  • Status: OFP
    • Legend:
    OFP - off patent
    OFM - off market
    ONP - on patent

Drug dosage:

DoseUnitRoute
0.15 g O

ADMET properties:

PropertyValueReference
BDDCS (Biopharmaceutical Drug Disposition Classification System) 1 Benet LZ, Broccatelli F, Oprea TI
S (Water solubility) 1000 mg/mL Benet LZ, Broccatelli F, Oprea TI

Approvals:

DateAgencyCompanyOrphan
Feb. 20, 1953 FDA HOSPIRA

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Pemphigus 1822.73 10.09 3881 435527 153331 55699328
Rheumatoid arthritis 1738.84 10.09 6728 432680 375876 55476783
Systemic lupus erythematosus 1692.17 10.09 4090 435318 175988 55676671
Glossodynia 1507.73 10.09 3533 435875 148925 55703734
Hand deformity 1224.23 10.09 3019 436389 131473 55721186
Arthropathy 1133.46 10.09 3788 435620 196487 55656172
Abdominal discomfort 1059.83 10.09 4627 434781 272647 55580012
Alopecia 1059.22 10.09 4814 434594 288644 55564015
Wound 1017.78 10.09 2875 436533 135929 55716730
Maternal exposure during pregnancy 976.15 10.09 3475 435933 186078 55666581
Synovitis 824.84 10.09 2951 436457 158354 55694305
Completed suicide 808.67 10.09 62 439346 133771 55718888
Pericarditis 796.01 10.09 2254 437154 106669 55745990
Infusion related reaction 779.41 10.09 3463 435945 205468 55647191
Anti-cyclic citrullinated peptide antibody positive 778.54 10.09 2099 437309 96501 55756158
Discomfort 760.42 10.09 2635 436773 139126 55713533
Contraindicated product administered 756.40 10.09 3168 436240 183118 55669541
Swelling 731.73 10.09 3750 435658 236021 55616638
Joint swelling 703.75 10.09 4261 435147 285539 55567120
Toxicity to various agents 637.62 10.09 492 438916 224072 55628587
Pain 613.85 10.09 7875 431533 655309 55197350
Death 543.63 10.09 1159 438249 340267 55512392
Product use issue 486 10.09 2790 436618 183251 55669408
Duodenal ulcer perforation 482.19 10.09 1397 438011 66945 55785714
Helicobacter infection 468.97 10.09 1447 437961 71821 55780838
Rheumatoid factor positive 468.42 10.09 1392 438016 67668 55784991
Hepatic enzyme increased 442.20 10.09 2562 436846 168822 55683837
Arthralgia 408.25 10.09 5825 433583 495844 55356815
Drug interaction 379.66 10.09 659 438749 209096 55643563
Drug abuse 362.55 10.09 49 439359 67561 55785098
Intentional overdose 361.42 10.09 51 439357 68066 55784593
Therapeutic product effect decreased 343.22 10.09 2382 437026 167070 55685589
Drug intolerance 341.75 10.09 3361 436047 261457 55591202
Musculoskeletal stiffness 317.07 10.09 2195 437213 153812 55698847
Treatment failure 307.51 10.09 2330 437078 168062 55684597
Exposure during pregnancy 297.80 10.09 1953 437455 134389 55718270
Febrile neutropenia 267.85 10.09 257 439151 105288 55747371
Hip arthroplasty 256.56 10.09 773 438635 37850 55814809
Acute kidney injury 244.28 10.09 1008 438400 239755 55612904
Psoriatic arthropathy 243.76 10.09 1184 438224 72824 55779835
Knee arthroplasty 243.24 10.09 830 438578 43429 55809230
Hypersensitivity 241.39 10.09 3059 436349 253349 55599310
Suicide attempt 238.43 10.09 77 439331 57759 55794900
Overdose 217.50 10.09 305 439103 105525 55747134
Depressed level of consciousness 215.80 10.09 85 439323 56348 55796311
Cardiac arrest 214.56 10.09 214 439194 86100 55766559
Nasopharyngitis 211.25 10.09 2644 436764 218315 55634344
Impaired healing 205.60 10.09 1270 438138 85571 55767088
Malignant neoplasm progression 197.61 10.09 170 439238 73417 55779242
Rheumatic fever 197.18 10.09 583 438825 28244 55824415
Constipation 195.83 10.09 860 438548 201083 55651576
Disease progression 193.23 10.09 327 439081 104846 55747813
Diarrhoea 192.53 10.09 3671 435737 634836 55217823
Red blood cell sedimentation rate abnormal 177.80 10.09 427 438981 18246 55834413
Swollen joint count increased 176.88 10.09 501 438907 23683 55828976
Nausea 176.08 10.09 4584 434824 759594 55093065
Neutropenia 171.24 10.09 645 438763 157522 55695137
Device expulsion 168.23 10.09 20 439388 30429 55822230
Folliculitis 165.08 10.09 857 438551 54122 55798537
Muscle injury 165.07 10.09 829 438579 51671 55800988
Blister 163.77 10.09 1429 437979 107458 55745201
Sedation 159.33 10.09 38 439370 34816 55817843
Sleep disorder due to general medical condition, insomnia type 154.07 10.09 709 438699 42629 55810030
Hypotension 153.95 10.09 1234 438174 249274 55603385
C-reactive protein abnormal 152.07 10.09 630 438778 36179 55816480
Anxiety 151.73 10.09 885 438523 192287 55660372
Bradycardia 151.59 10.09 182 439226 67322 55785337
Asthenia 149.50 10.09 1836 437572 341137 55511522
Cardiac failure 147.35 10.09 259 439149 81834 55770825
Drug ineffective 146.54 10.09 8658 430750 910331 54942328
Hyponatraemia 144.21 10.09 369 439039 101770 55750889
Lactic acidosis 144.02 10.09 48 439360 35298 55817361
Electrocardiogram QT prolonged 143.07 10.09 129 439279 54459 55798200
Tremor 142.93 10.09 476 438932 120613 55732046
Lower respiratory tract infection 133.86 10.09 1428 437980 113366 55739293
Irritable bowel syndrome 133.48 10.09 954 438454 67504 55785155
Sickle cell anaemia with crisis 133.42 10.09 180 439228 4848 55847811
Rash 132.84 10.09 4898 434510 488149 55364510
Somnolence 127.05 10.09 751 438657 162662 55689997
Dyspnoea 124.64 10.09 3599 435809 588978 55263681
Pregnancy 124.59 10.09 550 438858 32483 55820176
Vomiting 124.26 10.09 2952 436456 495276 55357383
Agitation 123.79 10.09 153 439255 55883 55796776
Drug hypersensitivity 123.74 10.09 1463 437945 273742 55578917
Fatigue 122.36 10.09 7413 431995 781139 55071520
Renal failure 121.26 10.09 448 438960 110052 55742607
Respiratory arrest 114.03 10.09 48 439360 30577 55822082
Dizziness 113.73 10.09 2160 437248 373980 55478679
Osteoarthritis 112.09 10.09 1037 438371 79259 55773400
Neuropathy peripheral 111.05 10.09 420 438988 102473 55750186
Drug reaction with eosinophilia and systemic symptoms 110.45 10.09 49 439359 30255 55822404
Hyperhidrosis 109.55 10.09 372 439036 93716 55758943
Asthma 109.36 10.09 480 438928 112290 55740369
Rhabdomyolysis 109.05 10.09 94 439314 40564 55812095
Multiple sclerosis relapse 108.53 10.09 114 439294 44789 55807870
Neoplasm progression 105.78 10.09 59 439349 31957 55820702
Arthritis 105.37 10.09 1218 438190 98634 55754025
Intentional self-injury 105.27 10.09 32 439376 24960 55827699
Syncope 105.25 10.09 460 438948 107739 55744920
Condition aggravated 104.58 10.09 3474 435934 341424 55511235
Sopor 101.34 10.09 20 439388 20902 55831757
Blood cholesterol increased 97.14 10.09 929 438479 71650 55781009
Tachycardia 95.92 10.09 462 438946 105414 55747245
Live birth 93.45 10.09 351 439057 19254 55833405
Myalgia 93.19 10.09 625 438783 131400 55721259
Drug dependence 92.85 10.09 30 439378 22503 55830156
Cognitive disorder 92.77 10.09 150 439258 48983 55803676
Serotonin syndrome 91.67 10.09 46 439362 26444 55826215
Cardio-respiratory arrest 90.93 10.09 184 439224 55137 55797522
Type 2 diabetes mellitus 90.72 10.09 652 438756 46210 55806449
Hypoglycaemia 88.91 10.09 189 439219 55626 55797033
Drug withdrawal syndrome 87.84 10.09 46 439362 25811 55826848
Abortion spontaneous 86.59 10.09 612 438796 43141 55809518
Hypoxia 86.27 10.09 182 439226 53715 55798944
Pulmonary arterial hypertension 84.49 10.09 51 439357 26452 55826207
Product quality issue 84.35 10.09 74 439334 31662 55820997
Anaemia 83.92 10.09 1526 437882 265985 55586674
Hepatic failure 83.21 10.09 83 439325 33403 55819256
Plasma cell myeloma 82.93 10.09 148 439260 46498 55806161
Ill-defined disorder 82.84 10.09 859 438549 67684 55784975
Thrombocytopenia 82.67 10.09 673 438735 135551 55717108
Seizure 81.12 10.09 607 438801 124512 55728147
Renal impairment 80.41 10.09 340 439068 80373 55772286
Peripheral swelling 79.90 10.09 2398 437010 232328 55620331
Respiratory failure 79.74 10.09 426 438982 94636 55758023
Blood pressure fluctuation 78.97 10.09 563 438845 39797 55812862
Hyperglycaemia 77.93 10.09 111 439297 38170 55814489
Insomnia 77.89 10.09 1042 438366 190818 55661841
Sedation complication 77.88 10.09 3 439405 11669 55840990
Cardiac failure congestive 77.58 10.09 386 439022 87334 55765325
Metabolic acidosis 76.85 10.09 123 439285 40331 55812328
No adverse event 76.53 10.09 103 439305 36271 55816388
Sinusitis 75.96 10.09 2050 437358 195531 55657128
Dehydration 74.53 10.09 836 438572 157989 55694670
Foot deformity 74.01 10.09 375 439033 23450 55829209
Orthostatic hypotension 74.00 10.09 90 439318 33109 55819550
Fibromyalgia 73.94 10.09 751 438657 58852 55793807
Joint effusion 73.75 10.09 270 439138 14628 55838031
Drug resistance 73.63 10.09 34 439374 20508 55832151
Liver injury 73.50 10.09 569 438839 41279 55811380
Balance disorder 73.38 10.09 327 439081 76193 55776466
Red blood cell sedimentation rate increased 72.90 10.09 513 438895 36110 55816549
Encephalopathy 72.34 10.09 102 439306 35223 55817436
Intentional product use issue 72.32 10.09 1137 438271 98596 55754063
Palmar-plantar erythrodysaesthesia syndrome 72.26 10.09 37 439371 21028 55831631
Depression 71.38 10.09 983 438425 179134 55673525
Feeling abnormal 71.38 10.09 682 438726 132920 55719739
Contusion 70.91 10.09 1402 438006 127028 55725631
Multiple organ dysfunction syndrome 69.66 10.09 197 439211 52573 55800086
Chest discomfort 69.23 10.09 469 438939 98388 55754271
Hallucination 66.72 10.09 181 439227 48968 55803691
Infection 65.87 10.09 2037 437371 198169 55654490
Coma 65.32 10.09 242 439166 59413 55793246
Vision blurred 65.04 10.09 380 439028 82563 55770096
Pulmonary embolism 63.72 10.09 532 438876 106592 55746067
Neutrophil count decreased 63.57 10.09 189 439219 49633 55803026
Injection site erythema 63.57 10.09 902 438506 76546 55776113
Disability assessment scale score increased 62.06 10.09 91 439317 2653 55850006
Hepatic function abnormal 62.01 10.09 109 439299 34449 55818210
Altered state of consciousness 62.01 10.09 53 439355 22968 55829691
Blood glucose increased 61.79 10.09 339 439069 74812 55777847
Blood pressure diastolic abnormal 61.51 10.09 215 439193 11383 55841276
Fluid retention 61.45 10.09 216 439192 53862 55798797
Grip strength decreased 60.79 10.09 270 439138 15986 55836673
White blood cell count decreased 60.75 10.09 659 438749 125331 55727328
Mental status changes 60.55 10.09 126 439282 37375 55815284
Cytomegalovirus infection 60.30 10.09 38 439370 19258 55833401
Cholestasis 59.94 10.09 73 439335 26840 55825819
Osteoporosis 59.91 10.09 646 438762 51406 55801253
Basal cell carcinoma 59.73 10.09 369 439039 24852 55827807
Urticaria 59.69 10.09 783 438625 143893 55708766
Bone erosion 59.27 10.09 253 439155 14721 55837938
Hyperkalaemia 59.26 10.09 201 439207 50664 55801995
Intentional product misuse 59.01 10.09 205 439203 51299 55801360
Disturbance in attention 58.97 10.09 102 439306 32438 55820221
Creatinine renal clearance decreased 58.91 10.09 20 439388 14539 55838120
Ejection fraction decreased 58.08 10.09 42 439366 19799 55832860
Muscle spasms 57.95 10.09 740 438668 136631 55716028
Diabetic ketoacidosis 57.83 10.09 38 439370 18833 55833826
Metastases to bone 57.49 10.09 41 439367 19467 55833192
Injection site pruritus 56.23 10.09 537 438871 41394 55811265
Muscle spasticity 56.19 10.09 44 439364 19916 55832743
Hypokalaemia 56.16 10.09 469 438939 93968 55758691
Weight increased 56.14 10.09 2259 437149 227444 55625215
Hepatocellular injury 55.86 10.09 75 439333 26439 55826220
Leukopenia 55.62 10.09 325 439083 70615 55782044
Loss of consciousness 55.54 10.09 565 438843 108784 55743875
Caesarean section 55.52 10.09 261 439147 15830 55836829
Joint laxity 55.33 10.09 81 439327 2358 55850301
Mydriasis 54.86 10.09 10 439398 11061 55841598
Blood pressure systolic abnormal 54.26 10.09 184 439224 9593 55843066
Respiratory disorder 54.06 10.09 115 439293 33842 55818817
Suicidal ideation 54.01 10.09 249 439159 57493 55795166
Angioedema 53.79 10.09 156 439252 41297 55811362
Platelet count decreased 53.49 10.09 551 438857 105832 55746827
Emotional distress 53.29 10.09 94 439314 29669 55822990
Blood pressure systolic increased 53.29 10.09 520 438888 40316 55812343
Loss of personal independence in daily activities 53.18 10.09 912 438496 80457 55772202
Blood pressure decreased 52.69 10.09 259 439149 58791 55793868
Blood calcium decreased 52.38 10.09 65 439343 23704 55828955
Osteonecrosis of jaw 52.25 10.09 114 439294 33244 55819415
Myocardial infarction 51.77 10.09 469 438939 92401 55760258
Dyspnoea exertional 50.47 10.09 237 439171 54452 55798207
Shock 50.47 10.09 57 439351 21671 55830988
Restlessness 50.34 10.09 81 439327 26505 55826154
Anaphylactic reaction 50.23 10.09 263 439145 58732 55793927
Product use in unapproved indication 50.05 10.09 785 438623 140037 55712622
Poisoning 49.47 10.09 19 439389 12794 55839865
Stomatitis 49.42 10.09 1264 438144 119546 55733113
Deep vein thrombosis 49.13 10.09 375 439033 76602 55776057
Decreased appetite 49.03 10.09 1319 438089 217912 55634747
Hypothermia 48.97 10.09 18 439390 12452 55840207
Schizophrenia 48.87 10.09 11 439397 10488 55842171
Flushing 48.86 10.09 333 439075 69767 55782892
Disorientation 48.83 10.09 136 439272 36477 55816182
Speech disorder 48.72 10.09 141 439267 37352 55815307
Acute hepatic failure 48.65 10.09 35 439373 16543 55836116
Pulmonary fibrosis 48.63 10.09 398 439010 29360 55823299
COVID-19 48.22 10.09 365 439043 74693 55777966
Blood creatine phosphokinase increased 47.63 10.09 91 439317 27861 55824798
Ascites 47.48 10.09 143 439265 37401 55815258
Drug level increased 47.45 10.09 55 439353 20670 55831989
Bone pain 47.19 10.09 216 439192 49969 55802690
Dysphagia 46.92 10.09 411 438997 81536 55771123
Unresponsive to stimuli 46.79 10.09 112 439296 31613 55821046
Pain in jaw 46.78 10.09 158 439250 39878 55812781
Blood alkaline phosphatase increased 46.67 10.09 152 439256 38793 55813866
Extrapyramidal disorder 46.59 10.09 19 439389 12337 55840322
C-reactive protein increased 46.49 10.09 868 438540 77816 55774843
Foetal exposure during pregnancy 46.26 10.09 435 438973 33388 55819271
Palpitations 46.19 10.09 526 438882 99146 55753513
Hospitalisation 46.18 10.09 369 439039 74631 55778028
Aspartate aminotransferase increased 46.10 10.09 417 438991 82185 55770474
Multiple fractures 46.00 10.09 144 439264 7197 55845462
Inflammation 45.80 10.09 776 438632 68295 55784364
Respiratory depression 45.48 10.09 20 439388 12415 55840244
Joint range of motion decreased 45.16 10.09 346 439062 25019 55827640
Memory impairment 44.88 10.09 445 438963 86112 55766547
Metastases to liver 44.52 10.09 62 439346 21524 55831135
Gamma-glutamyltransferase increased 44.52 10.09 111 439297 30894 55821765
Product administration error 44.29 10.09 59 439349 20870 55831789
Dysgeusia 44.12 10.09 167 439241 40748 55811911
Drug tolerance decreased 43.71 10.09 214 439194 13197 55839462
Injection site reaction 43.63 10.09 620 438788 52627 55800032
Drug ineffective for unapproved indication 43.47 10.09 84 439324 25609 55827050
Abnormal behaviour 43.05 10.09 57 439351 20215 55832444
Cerebral haemorrhage 42.98 10.09 100 439308 28506 55824153
Premature labour 42.67 10.09 195 439213 11687 55840972
Disability 42.61 10.09 239 439169 15541 55837118
Neck deformity 42.47 10.09 65 439343 1970 55850689
Gestational diabetes 42.34 10.09 149 439259 7915 55844744
Anaphylactic shock 42.34 10.09 65 439343 21675 55830984
Blood bilirubin increased 42.21 10.09 127 439281 33227 55819432
Multiple sclerosis 41.92 10.09 97 439311 27705 55824954
Pulmonary oedema 41.87 10.09 231 439177 50912 55801747
Wrong technique in product usage process 41.70 10.09 274 439134 57894 55794765
Blood pressure diastolic decreased 41.62 10.09 276 439132 19047 55833612
Atrial fibrillation 41.45 10.09 599 438809 108298 55744361
Rheumatoid nodule 41.44 10.09 227 439181 14630 55838029
Chronic kidney disease 41.36 10.09 178 439230 41878 55810781
Joint destruction 41.22 10.09 109 439299 4946 55847713
Torsade de pointes 40.98 10.09 23 439385 12417 55840242
Product dose omission issue 40.94 10.09 1251 438157 203502 55649157
Alanine aminotransferase increased 40.81 10.09 501 438907 93161 55759498
Cytokine release syndrome 40.56 10.09 17 439391 10858 55841801
Pleural effusion 40.44 10.09 449 438959 85031 55767628
Disseminated intravascular coagulation 40.37 10.09 48 439360 17837 55834822
Sepsis 40.31 10.09 809 438599 139031 55713628
Accidental overdose 40.01 10.09 61 439347 20400 55832259
Dysarthria 39.75 10.09 166 439242 39384 55813275
Vertigo 39.65 10.09 256 439152 54316 55798343
Maternal exposure before pregnancy 39.27 10.09 130 439278 6693 55845966
Arrhythmia 39.27 10.09 141 439267 34942 55817717
Posterior reversible encephalopathy syndrome 39.15 10.09 40 439368 15920 55836739
Device dislocation 39.04 10.09 73 439335 22533 55830126
Maternal drugs affecting foetus 38.70 10.09 107 439301 4986 55847673
Joint stiffness 38.63 10.09 435 438973 34990 55817669
Chest pain 38.59 10.09 1157 438251 188640 55664019
Psychotic disorder 38.16 10.09 79 439329 23479 55829180
Cerebrovascular accident 38.15 10.09 545 438863 98725 55753934
Withdrawal syndrome 38.11 10.09 53 439355 18409 55834250
Injection site swelling 37.96 10.09 513 438895 43065 55809594
Pulmonary hypertension 37.93 10.09 148 439260 35796 55816863
Polyarthritis 37.31 10.09 151 439257 8577 55844082
Infective pulmonary exacerbation of cystic fibrosis 37.07 10.09 9 439399 8148 55844511
Tuberculosis 36.67 10.09 177 439231 10852 55841807
Akathisia 36.58 10.09 11 439397 8641 55844018
Ventricular tachycardia 36.43 10.09 47 439361 16854 55835805
Respiratory distress 36.30 10.09 126 439282 31541 55821118
Nightmare 36.05 10.09 47 439361 16779 55835880
Delirium 35.93 10.09 190 439218 42327 55810332
Haemorrhage 35.87 10.09 275 439133 56122 55796537
Back pain 35.39 10.09 1502 437906 235668 55616991
Neuroleptic malignant syndrome 35.33 10.09 23 439385 11455 55841204
Gastrointestinal haemorrhage 35.11 10.09 401 439007 75550 55777109
Acute respiratory failure 35.07 10.09 124 439284 30870 55821789
International normalised ratio increased 34.93 10.09 201 439207 43840 55808819
Enthesopathy 34.87 10.09 140 439268 7923 55844736
Nodule 34.85 10.09 257 439151 18362 55834297
Gastrointestinal disorder 34.74 10.09 1138 438270 111564 55741095
Laryngitis 34.37 10.09 206 439202 13724 55838935
Melaena 34.18 10.09 110 439298 28180 55824479
Juvenile idiopathic arthritis 34.04 10.09 98 439310 4675 55847984
Device difficult to use 33.89 10.09 21 439387 10740 55841919
Joint dislocation 33.79 10.09 225 439183 15548 55837111
Eosinophilia 33.65 10.09 66 439342 20011 55832648
Ventricular fibrillation 33.63 10.09 22 439386 10930 55841729
Accidental exposure to product 33.27 10.09 91 439317 24556 55828103
Inappropriate antidiuretic hormone secretion 33.15 10.09 35 439373 13721 55838938
Brain oedema 32.85 10.09 33 439375 13238 55839421
Coagulopathy 32.71 10.09 60 439348 18656 55834003
Blood creatinine increased 32.69 10.09 435 438973 79756 55772903
Dyskinesia 32.57 10.09 117 439291 28991 55823668
Ventricular septal defect 32.50 10.09 88 439320 4050 55848609
Breast cancer metastatic 32.34 10.09 44 439364 15425 55837234
Tenderness 32.09 10.09 268 439140 19887 55832772
Musculoskeletal pain 31.99 10.09 845 438563 80307 55772352
Neurotoxicity 31.95 10.09 46 439362 15749 55836910
Polyneuropathy 31.68 10.09 33 439375 13017 55839642
Mania 31.67 10.09 26 439382 11494 55841165
Irritability 31.11 10.09 122 439286 29466 55823193
Jaundice 31.01 10.09 109 439299 27185 55825474
Parkinsonism 30.95 10.09 18 439390 9528 55843131
Limb deformity 30.76 10.09 83 439325 3812 55848847
Injection site pain 30.49 10.09 1160 438248 115958 55736701
Toxic skin eruption 30.44 10.09 28 439380 11711 55840948
Blood potassium decreased 30.40 10.09 177 439231 38495 55814164
Bronchospasm 30.37 10.09 47 439361 15622 55837037
Latent tuberculosis 30.32 10.09 63 439345 2439 55850220
Pre-eclampsia 30.27 10.09 139 439269 8347 55844312
Abdominal pain 30.17 10.09 1682 437726 257123 55595536
Thrombotic microangiopathy 30.15 10.09 18 439390 9393 55843266
Pancreatitis acute 30.14 10.09 98 439310 25026 55827633
Localised infection 30.07 10.09 337 439071 27075 55825584
Acute myeloid leukaemia 30.03 10.09 54 439354 16918 55835741
Status epilepticus 29.74 10.09 45 439363 15096 55837563
Heart rate decreased 29.70 10.09 462 438946 39965 55812694
Adverse event 29.69 10.09 602 438806 54774 55797885
Femur fracture 29.61 10.09 451 438957 38844 55813815
Agranulocytosis 29.60 10.09 85 439323 22574 55830085
Premature rupture of membranes 29.43 10.09 93 439315 4672 55847987
Disease recurrence 29.37 10.09 92 439316 23768 55828891
Psoriasis 29.35 10.09 939 438469 91753 55760906
Depressed mood 29.34 10.09 165 439243 36194 55816465
Hemiparesis 29.27 10.09 79 439329 21411 55831248
Asphyxia 29.18 10.09 5 439403 5784 55846875
Transplant rejection 29.11 10.09 21 439387 9913 55842746
Lethargy 29.00 10.09 259 439149 51182 55801477
Diabetes mellitus inadequate control 28.99 10.09 40 439368 13940 55838719
Face oedema 28.95 10.09 63 439345 18389 55834270
Obstructive airways disorder 28.80 10.09 57 439351 17225 55835434
Acute generalised exanthematous pustulosis 28.75 10.09 21 439387 9848 55842811
Tenosynovitis 28.68 10.09 181 439227 12280 55840379
Small for dates baby 28.66 10.09 76 439332 3454 55849205
Macular degeneration 28.48 10.09 66 439342 18842 55833817
Tenosynovitis stenosans 28.43 10.09 63 439345 2551 55850108
Haematotoxicity 28.34 10.09 15 439393 8368 55844291
Crying 28.32 10.09 80 439328 21360 55831299
Stress cardiomyopathy 28.06 10.09 15 439393 8321 55844338
Metastases to central nervous system 28.01 10.09 32 439376 12104 55840555
Paralysis 27.93 10.09 18 439390 9014 55843645
Hypervolaemia 27.88 10.09 109 439299 26349 55826310
Atrioventricular block complete 27.49 10.09 12 439396 7482 55845177
Blood pressure diastolic increased 27.47 10.09 136 439272 8425 55844234
Dystonia 27.33 10.09 34 439374 12387 55840272
Injection site rash 27.27 10.09 226 439182 16732 55835927
Panic attack 27.22 10.09 76 439332 20371 55832288
Lupus-like syndrome 27.06 10.09 178 439230 12249 55840410
Hypomagnesaemia 27.04 10.09 102 439306 24913 55827746
Unevaluable event 26.92 10.09 240 439168 47447 55805212
Second primary malignancy 26.92 10.09 12 439396 7390 55845269
Smear cervix abnormal 26.91 10.09 64 439344 2717 55849942
Device use error 26.88 10.09 5 439403 5451 55847208
Fear 26.76 10.09 47 439361 14861 55837798
Dry skin 26.64 10.09 237 439171 46872 55805787
Injection site bruising 26.34 10.09 435 438973 38086 55814573
Immune reconstitution inflammatory syndrome 26.30 10.09 6 439402 5668 55846991
Fall 26.23 10.09 2418 436990 355092 55497567
Cardiogenic shock 26.22 10.09 55 439353 16270 55836389
Headache 26.16 10.09 3897 435511 555147 55297512
Complication associated with device 26.13 10.09 50 439358 15300 55837359
Complication of device insertion 25.69 10.09 9 439399 6415 55846244
Tachypnoea 25.62 10.09 51 439357 15379 55837280
Cytopenia 25.62 10.09 23 439385 9732 55842927
Stevens-Johnson syndrome 25.42 10.09 91 439317 22572 55830087
Hepatotoxicity 25.34 10.09 141 439267 31012 55821647
Wheelchair user 25.34 10.09 97 439311 5369 55847290
Bradyphrenia 25.25 10.09 10 439398 6610 55846049
Hypomania 25.23 10.09 4 439404 4898 55847761
Synovial cyst 25.18 10.09 140 439268 9074 55843585
Abdominal distension 25.17 10.09 440 438968 77186 55775473
Miosis 25.08 10.09 10 439398 6582 55846077
Febrile bone marrow aplasia 24.95 10.09 10 439398 6562 55846097
Maternal exposure timing unspecified 24.94 10.09 96 439312 5327 55847332
Substance abuse 24.93 10.09 3 439405 4522 55848137
Aggression 24.93 10.09 88 439320 21918 55830741
Nervousness 24.89 10.09 129 439279 28886 55823773
Tardive dyskinesia 24.84 10.09 16 439392 8015 55844644
Dysmorphism 24.82 10.09 54 439354 2159 55850500
Graft versus host disease 24.65 10.09 11 439397 6770 55845889
Myoclonus 24.61 10.09 51 439357 15152 55837507
Cardiac failure acute 24.42 10.09 20 439388 8853 55843806
Ischaemic stroke 24.41 10.09 60 439348 16782 55835877
Dementia 24.19 10.09 62 439346 17096 55835563
Anhedonia 24.14 10.09 25 439383 9889 55842770
Lymphocyte count decreased 24.09 10.09 124 439284 27815 55824844
Haemorrhage intracranial 24.02 10.09 39 439369 12716 55839943
Skin ulcer 23.88 10.09 429 438979 38179 55814480
Metastases to lung 23.83 10.09 34 439374 11684 55840975
Proteinuria 23.62 10.09 65 439343 17505 55835154
Genital haemorrhage 23.61 10.09 12 439396 6850 55845809
Mobility decreased 23.55 10.09 971 438437 98020 55754639
Urinary retention 23.42 10.09 126 439282 27948 55824711
Dislocation of vertebra 23.40 10.09 94 439314 5321 55847338
Erythema multiforme 23.37 10.09 24 439384 9530 55843129
Myelosuppression 23.15 10.09 65 439343 17390 55835269
Glycosylated haemoglobin increased 23.09 10.09 32 439376 11133 55841526
Therapeutic response decreased 23.05 10.09 557 438851 52201 55800458
Retinitis 23.00 10.09 79 439329 4145 55848514
Pain in extremity 22.98 10.09 2655 436753 294776 55557883
Red blood cell sedimentation rate 22.96 10.09 80 439328 4228 55848431
Tumour lysis syndrome 22.89 10.09 17 439391 7906 55844753
Hallucination, auditory 22.88 10.09 34 439374 11490 55841169
Hyperlipidaemia 22.88 10.09 69 439339 18040 55834619
Body temperature decreased 22.85 10.09 229 439179 17879 55834780
Pyrexia 22.78 10.09 2892 436516 415881 55436778
Sinus tachycardia 22.68 10.09 94 439314 22350 55830309
Synovial fluid analysis 22.55 10.09 48 439360 1890 55850769
Psychomotor hyperactivity 22.55 10.09 26 439382 9794 55842865
Clostridium difficile colitis 22.54 10.09 73 439335 18665 55833994
Hallucination, visual 22.47 10.09 66 439342 17402 55835257
Acute graft versus host disease 22.43 10.09 3 439405 4172 55848487
Infusion site pain 22.41 10.09 46 439362 13716 55838943
Arthritis infective 22.32 10.09 99 439309 5857 55846802
Product adhesion issue 22.32 10.09 4 439404 4479 55848180
Neck mass 22.28 10.09 68 439340 3352 55849307
Subdural haematoma 22.09 10.09 45 439363 13454 55839205
Developmental hip dysplasia 22.09 10.09 38 439370 1273 55851386
General physical health deterioration 22.08 10.09 1576 437832 168434 55684225
Angina pectoris 22.01 10.09 128 439280 27848 55824811
Myocarditis 21.95 10.09 22 439386 8836 55843823
Aphasia 21.93 10.09 143 439265 30272 55822387
Skin papilloma 21.92 10.09 81 439327 4408 55848251
Muscular weakness 21.89 10.09 634 438774 103818 55748841
Haematoma 21.86 10.09 153 439255 31866 55820793
Placental disorder 21.76 10.09 40 439368 1413 55851246
Loose body in joint 21.75 10.09 37 439371 1228 55851431
Haemoptysis 21.72 10.09 120 439288 26440 55826219
Cerebral infarction 21.67 10.09 96 439312 22409 55830250
Colitis 21.65 10.09 215 439193 41596 55811063
Pancreatitis 21.63 10.09 236 439172 44844 55807815
Uterine perforation 21.47 10.09 12 439396 6493 55846166
Myopathy 21.44 10.09 27 439381 9785 55842874
Leukocytosis 21.42 10.09 104 439304 23687 55828972
Breast cancer stage I 21.28 10.09 11 439397 6219 55846440
Haemophagocytic lymphohistiocytosis 21.27 10.09 26 439382 9546 55843113
Device related infection 21.27 10.09 93 439315 21787 55830872
Oedema peripheral 21.24 10.09 1106 438302 170148 55682511
Hypophagia 21.21 10.09 135 439273 28741 55823918
Cholecystitis chronic 21.12 10.09 27 439381 9721 55842938
Rotator cuff repair 21.07 10.09 46 439362 1844 55850815
Atrioventricular block 20.92 10.09 14 439394 6873 55845786
Acidosis 20.83 10.09 31 439377 10470 55842189
Rash maculo-papular 20.80 10.09 136 439272 28771 55823888
Skin exfoliation 20.70 10.09 186 439222 36714 55815945
Pulmonary congestion 20.65 10.09 61 439347 16054 55836605
Peripheral venous disease 20.53 10.09 142 439266 9937 55842722
Diabetes mellitus 20.43 10.09 289 439119 52446 55800213
Complication of device removal 20.41 10.09 5 439403 4499 55848160
Aspergillus infection 20.33 10.09 17 439391 7448 55845211
Lip dry 20.30 10.09 138 439270 9602 55843057
Sleep apnoea syndrome 20.10 10.09 120 439288 25941 55826718
Malignant melanoma 20.08 10.09 148 439260 10571 55842088
Generalised oedema 19.98 10.09 53 439355 14448 55838211
Bronchopulmonary aspergillosis 19.94 10.09 21 439387 8243 55844416
Paradoxical drug reaction 19.93 10.09 3 439405 3817 55848842
Blood glucose decreased 19.88 10.09 79 439329 19008 55833651
Hypertransaminasaemia 19.87 10.09 6 439402 4701 55847958
Premature delivery 19.78 10.09 309 439099 26751 55825908
Polyhydramnios 19.74 10.09 48 439360 2067 55850592
Muscle twitching 19.73 10.09 63 439345 16179 55836480
Hot flush 19.58 10.09 252 439156 46474 55806185
Epilepsy 19.55 10.09 116 439292 25115 55827544
Ketoacidosis 19.52 10.09 4 439404 4071 55848588
Pericardial effusion 19.47 10.09 128 439280 27047 55825612
Bone marrow failure 19.39 10.09 135 439273 28151 55824508
Exostosis 19.35 10.09 190 439218 14753 55837906
Hereditary angioedema 19.32 10.09 15 439393 6820 55845839
Tubulointerstitial nephritis 19.31 10.09 66 439342 16599 55836060
Salivary hypersecretion 19.27 10.09 16 439392 7034 55845625
Mental disorder 19.11 10.09 107 439301 23497 55829162
Cardiomyopathy 19.10 10.09 64 439344 16194 55836465
Lymphoedema 19.08 10.09 33 439375 10497 55842162
Spinal stenosis 19.04 10.09 180 439228 13834 55838825
Affective disorder 18.98 10.09 10 439398 5593 55847066
Facet joint syndrome 18.98 10.09 103 439305 6614 55846045
Body height below normal 18.98 10.09 46 439362 1977 55850682
Exposure to toxic agent 18.94 10.09 3 439405 3675 55848984
Hypophosphataemia 18.90 10.09 29 439379 9673 55842986
Muscle rigidity 18.83 10.09 34 439374 10637 55842022
Cushingoid 18.73 10.09 110 439298 7274 55845385
Lip swelling 18.70 10.09 124 439284 26148 55826511
Delusion 18.68 10.09 37 439371 11178 55841481
Acute chest syndrome 18.68 10.09 25 439383 668 55851991
Rash erythematous 18.61 10.09 193 439215 37028 55815631
Atrial septal defect 18.55 10.09 100 439308 6406 55846253
Chills 18.54 10.09 635 438773 101969 55750690
Dysuria 18.53 10.09 152 439256 30577 55822082
Pathogen resistance 18.50 10.09 12 439396 5988 55846671
Gastroenteritis viral 18.43 10.09 242 439166 20182 55832477
Eating disorder 18.32 10.09 70 439338 17035 55835624
Temperature regulation disorder 18.32 10.09 6 439402 4462 55848197
Hypothyroidism 18.31 10.09 200 439208 37996 55814663
Swollen tongue 18.29 10.09 150 439258 30174 55822485
Mood altered 18.26 10.09 49 439359 13306 55839353
Hyperthyroidism 18.25 10.09 49 439359 13303 55839356
Right ventricular failure 18.22 10.09 66 439342 16313 55836346
Incorrect route of product administration 18.20 10.09 95 439313 21234 55831425
Infusion site swelling 18.16 10.09 21 439387 7900 55844759
Cyanosis 18.06 10.09 63 439345 15747 55836912
Joint noise 18.04 10.09 68 439340 3736 55848923
Multiple allergies 18.03 10.09 34 439374 10462 55842197
Personality disorder 17.87 10.09 9 439399 5164 55847495
Pseudomonas infection 17.85 10.09 32 439376 10039 55842620
Respiration abnormal 17.78 10.09 11 439397 5630 55847029
Wound infection 17.68 10.09 189 439219 15004 55837655
Malaise 17.65 10.09 2560 436848 365300 55487359
Malignant mediastinal neoplasm 17.63 10.09 28 439380 877 55851782
Shock haemorrhagic 17.60 10.09 27 439381 9006 55843653
Foetal anticonvulsant syndrome 17.55 10.09 22 439386 550 55852109
Urinary incontinence 17.54 10.09 147 439261 29438 55823221
Cough 17.53 10.09 1769 437639 258192 55594467
Catheter site erythema 17.53 10.09 5 439403 4065 55848594
Infusion site erythema 17.50 10.09 30 439378 9576 55843083
Vascular device infection 17.48 10.09 11 439397 5579 55847080
Congenital arterial malformation 17.35 10.09 17 439391 320 55852339
Device breakage 17.32 10.09 33 439375 10114 55842545
Klebsiella infection 17.31 10.09 21 439387 7735 55844924
Pulmonary tuberculosis 17.23 10.09 75 439333 4401 55848258
Fear of injection 17.14 10.09 98 439310 6417 55846242
Acute myocardial infarction 17.14 10.09 153 439255 30240 55822419
Postoperative wound infection 17.12 10.09 128 439280 9185 55843474
Obesity 17.05 10.09 258 439150 22190 55830469
Anuria 16.96 10.09 42 439366 11718 55840941
Dermatitis atopic 16.95 10.09 24 439384 8275 55844384
Coronary artery disease 16.94 10.09 156 439252 30640 55822019
Synovial disorder 16.92 10.09 31 439377 1092 55851567
Renal injury 16.90 10.09 27 439381 8860 55843799
Toxic epidermal necrolysis 16.73 10.09 102 439306 21940 55830719
Hyperprolactinaemia 16.71 10.09 4 439404 3657 55849002
Oliguria 16.66 10.09 25 439383 8415 55844244
Presyncope 16.61 10.09 124 439284 25458 55827201
Clear cell renal cell carcinoma 16.49 10.09 33 439375 1243 55851416
Fracture delayed union 16.48 10.09 48 439360 2305 55850354
Anti-cyclic citrullinated peptide antibody 16.39 10.09 65 439343 3658 55849001
Adjustment disorder with depressed mood 16.33 10.09 81 439327 5022 55847637
Polyuria 16.27 10.09 21 439387 7530 55845129
Haemorrhage in pregnancy 16.25 10.09 40 439368 1736 55850923
Taste disorder 16.23 10.09 32 439376 9683 55842976
Rebound effect 16.22 10.09 5 439403 3865 55848794
Bursitis 16.19 10.09 304 439104 27278 55825381
Breast feeding 16.15 10.09 26 439382 824 55851835
Epistaxis 16.08 10.09 399 439009 66624 55786035
Injection site warmth 16.03 10.09 176 439232 14067 55838592
Circulatory collapse 15.93 10.09 96 439312 20707 55831952
Epstein-Barr virus infection 15.83 10.09 21 439387 7442 55845217
Aspiration 15.80 10.09 32 439376 9589 55843070
Purpura 15.75 10.09 36 439372 10326 55842333
Tendonitis 15.74 10.09 213 439195 17884 55834775
Product preparation error 15.73 10.09 9 439399 4807 55847852
Scleritis 15.70 10.09 64 439344 3647 55849012
Visual acuity reduced 15.69 10.09 96 439312 20630 55832029
Bradypnoea 15.64 10.09 3 439405 3200 55849459
Catheter site pain 15.55 10.09 7 439401 4286 55848373
Bundle branch block left 15.54 10.09 16 439392 6346 55846313
Hemiplegia 15.54 10.09 26 439382 8378 55844281
Product substitution issue 15.47 10.09 60 439348 14539 55838120
Labelled drug-drug interaction medication error 15.47 10.09 43 439365 11543 55841116
Renal disorder 15.42 10.09 152 439256 29453 55823206
Off label use 15.37 10.09 3983 435425 552197 55300462
Foetal death 15.21 10.09 117 439291 8470 55844189
Multiple-drug resistance 15.16 10.09 6 439402 3968 55848691
Mouth ulceration 15.16 10.09 320 439088 29320 55823339
Human antichimeric antibody positive 15.16 10.09 36 439372 1527 55851132
Injection site haematoma 15.13 10.09 92 439316 6160 55846499
Head injury 15.11 10.09 124 439284 24942 55827717
Paranoia 15.01 10.09 39 439369 10705 55841954
Exomphalos 14.98 10.09 20 439388 533 55852126
Body temperature increased 14.97 10.09 183 439225 34059 55818600
Dactylitis 14.96 10.09 43 439365 2049 55850610
Rhinitis allergic 14.96 10.09 27 439381 8447 55844212
Antinuclear antibody positive 14.90 10.09 98 439310 6743 55845916
Colitis microscopic 14.90 10.09 24 439384 7851 55844808
Talipes 14.84 10.09 34 439374 1408 55851251
Hallucinations, mixed 14.83 10.09 8 439400 4416 55848243
Fracture 14.83 10.09 210 439198 17808 55834851
Incorrect product administration duration 14.80 10.09 37 439371 10289 55842370
Treatment noncompliance 14.78 10.09 173 439235 32450 55820209
Ankylosing spondylitis 14.74 10.09 130 439278 9800 55842859
Amylase increased 14.69 10.09 14 439394 5757 55846902
Pulseless electrical activity 14.66 10.09 20 439388 7004 55845655
Renal tubular necrosis 14.60 10.09 40 439368 10788 55841871
Skin cancer 14.57 10.09 134 439274 10221 55842438
Respiratory acidosis 14.50 10.09 16 439392 6147 55846512
Hepatitis acute 14.42 10.09 27 439381 8330 55844329
Systemic inflammatory response syndrome 14.40 10.09 12 439396 5266 55847393
Anger 14.37 10.09 45 439363 11627 55841032
Device issue 14.34 10.09 101 439307 21005 55831654
Peripheral sensory neuropathy 14.32 10.09 20 439388 6936 55845723
Gestational hypertension 14.32 10.09 45 439363 2254 55850405
Infusion site pruritus 14.30 10.09 10 439398 4797 55847862
Product prescribing error 14.30 10.09 114 439294 23072 55829587
Sinus bradycardia 14.29 10.09 56 439352 13530 55839129
Oropharyngeal pain 14.23 10.09 795 438613 82993 55769666
Visual impairment 14.17 10.09 456 438952 73746 55778913
Potentiating drug interaction 14.16 10.09 7 439401 4059 55848600
Blood loss anaemia 14.14 10.09 27 439381 8270 55844389
Stillbirth 14.14 10.09 90 439318 6124 55846535
Tumour marker increased 14.05 10.09 8 439400 4285 55848374
Product complaint 14.02 10.09 46 439362 11714 55840945
Immunodeficiency 13.99 10.09 190 439218 15967 55836692
Paraesthesia 13.96 10.09 855 438553 129659 55723000
Bundle branch block right 13.96 10.09 10 439398 4737 55847922
Transplant dysfunction 13.95 10.09 10 439398 4736 55847923
Troponin increased 13.95 10.09 29 439379 8606 55844053
Pharyngitis streptococcal 13.92 10.09 124 439284 9374 55843285
Schizoaffective disorder 13.91 10.09 3 439405 2946 55849713
Polydipsia 13.88 10.09 4 439404 3231 55849428
Cardiotoxicity 13.84 10.09 24 439384 7626 55845033
Antibody test positive 13.71 10.09 46 439362 2385 55850274
Cardiac disorder 13.65 10.09 264 439144 45623 55807036
Progressive multifocal leukoencephalopathy 13.63 10.09 48 439360 11965 55840694
Restless legs syndrome 13.62 10.09 77 439331 16870 55835789
Acute pulmonary oedema 13.59 10.09 24 439384 7573 55845086
Catatonia 13.54 10.09 7 439401 3957 55848702
Abnormal dreams 13.50 10.09 35 439373 9614 55843045
Ileus 13.50 10.09 59 439349 13823 55838836
Pregnancy with contraceptive device 13.50 10.09 8 439400 4191 55848468
Laryngospasm 13.47 10.09 3 439405 2881 55849778
Hepatic cytolysis 13.46 10.09 42 439366 10864 55841795
Rectal haemorrhage 13.45 10.09 235 439173 41232 55811427
Acute respiratory distress syndrome 13.43 10.09 108 439300 21818 55830841
Prescribed underdose 13.43 10.09 231 439177 20386 55832273
Colorectal cancer 13.38 10.09 5 439403 3424 55849235
Pneumonia viral 13.37 10.09 22 439386 7136 55845523
Toxic encephalopathy 13.33 10.09 16 439392 5922 55846737
Abdominal pain upper 13.33 10.09 1204 438204 177109 55675550
Dermatitis exfoliative 13.32 10.09 13 439395 5286 55847373
Drug abuser 13.30 10.09 3 439405 2856 55849803
Ear infection 13.24 10.09 329 439079 30966 55821693
Trigeminal neuralgia 13.24 10.09 5 439403 3402 55849257
Product administered to patient of inappropriate age 13.22 10.09 3 439405 2845 55849814
Affect lability 13.21 10.09 38 439370 10087 55842572
Tongue disorder 13.19 10.09 128 439280 9908 55842751
Sexual dysfunction 13.12 10.09 5 439403 3383 55849276
Catheter management 13.07 10.09 3 439405 2823 55849836
Blood iron increased 13.01 10.09 32 439376 1388 55851271
Middle insomnia 12.94 10.09 43 439365 10907 55841752
Speech disorder developmental 12.93 10.09 20 439388 612 55852047
Bone lesion 12.88 10.09 14 439394 5416 55847243
Neonatal respiratory distress syndrome 12.87 10.09 49 439359 2705 55849954
Foetal distress syndrome 12.82 10.09 30 439378 1260 55851399
Intracranial pressure increased 12.82 10.09 10 439398 4535 55848124
Plasma cell myeloma recurrent 12.72 10.09 3 439405 2771 55849888
Sleep disorder due to a general medical condition 12.69 10.09 33 439375 9057 55843602
Hepatitis cholestatic 12.66 10.09 19 439389 6395 55846264
Pulmonary haemorrhage 12.53 10.09 21 439387 6762 55845897
Neutropenic colitis 12.52 10.09 3 439405 2740 55849919
Pulmonary alveolar haemorrhage 12.51 10.09 9 439399 4255 55848404
Full blood count abnormal 12.50 10.09 139 439269 26323 55826336
Acute coronary syndrome 12.50 10.09 37 439371 9731 55842928
Herpes zoster 12.49 10.09 718 438690 75171 55777488
Poor venous access 12.47 10.09 149 439259 12157 55840502
Rheumatoid lung 12.39 10.09 53 439355 3087 55849572
Cytomegalovirus viraemia 12.37 10.09 13 439395 5107 55847552
Food allergy 12.35 10.09 32 439376 8792 55843867
Cholestasis of pregnancy 12.33 10.09 28 439380 1153 55851506
Oral herpes 12.32 10.09 249 439159 22641 55830018
Embedded device 12.30 10.09 4 439404 2989 55849670
Autism spectrum disorder 12.27 10.09 22 439386 762 55851897
Lymphatic fistula 12.23 10.09 22 439386 764 55851895
Tinnitus 12.22 10.09 163 439245 29879 55822780
Somnambulism 12.22 10.09 13 439395 5079 55847580
Immunosuppression 12.20 10.09 105 439303 7859 55844800
Cervical incompetence 12.20 10.09 19 439389 585 55852074
Joint lock 12.16 10.09 41 439367 2131 55850528
Induced labour 12.16 10.09 24 439384 895 55851764
Blood parathyroid hormone decreased 12.16 10.09 109 439299 8255 55844404
Human anti-human antibody test 12.14 10.09 16 439392 421 55852238
Deep vein thrombosis postoperative 12.13 10.09 63 439345 3978 55848681
Ileus paralytic 12.12 10.09 9 439399 4186 55848473
Hyperuricaemia 12.12 10.09 13 439395 5060 55847599
Therapy change 12.10 10.09 15 439393 5473 55847186
Bradykinesia 12.09 10.09 12 439396 4842 55847817
Intervertebral disc degeneration 12.08 10.09 167 439241 14087 55838572
Inadequate analgesia 12.03 10.09 3 439405 2668 55849991
Lung transplant 12.01 10.09 4 439404 2943 55849716
Drug screen positive 12.01 10.09 6 439402 3458 55849201
Foot fracture 11.99 10.09 238 439170 21571 55831088
Eosinophil count increased 11.97 10.09 37 439371 9600 55843059
Femoral hernia incarcerated 11.93 10.09 22 439386 779 55851880
Electrolyte imbalance 11.91 10.09 87 439321 17946 55834713
Ulcer 11.91 10.09 244 439164 22241 55830418
Granuloma skin 11.90 10.09 95 439313 6956 55845703
Onychomycosis 11.89 10.09 90 439318 6482 55846177
Joint injury 11.86 10.09 273 439135 25381 55827278
Ataxia 11.82 10.09 65 439343 14338 55838321
Product physical issue 11.80 10.09 11 439397 4571 55848088
Blood urea increased 11.78 10.09 128 439280 24345 55828314
Hypertelorism 11.77 10.09 16 439392 434 55852225
Occult blood 11.77 10.09 28 439380 1189 55851470
Hypernatraemia 11.77 10.09 21 439387 6599 55846060
Squamous cell carcinoma 11.75 10.09 106 439302 8042 55844617
Embolism 11.67 10.09 25 439383 7339 55845320
Oxygen consumption increased 11.55 10.09 7 439401 3624 55849035
Atrial flutter 11.54 10.09 35 439373 9134 55843525
Lipase increased 11.50 10.09 34 439374 8945 55843714
Blood sodium decreased 11.49 10.09 115 439293 22219 55830440
Abortion incomplete 11.48 10.09 5 439403 3122 55849537
Ageusia 11.46 10.09 54 439354 12397 55840262
Forceps delivery 11.45 10.09 11 439397 202 55852457
Sickle cell anaemia 11.44 10.09 18 439390 559 55852100
Haemodialysis 11.39 10.09 32 439376 8559 55844100
Wound infection pseudomonas 11.38 10.09 29 439379 1286 55851373
Cyst 11.36 10.09 151 439257 12627 55840032
Pneumonia 11.34 10.09 2914 436494 404184 55448475
Joint warmth 11.34 10.09 31 439377 1435 55851224
Pancreatic steatosis 11.29 10.09 24 439384 944 55851715
Incoherent 11.29 10.09 10 439398 4259 55848400
Pemphigoid 11.18 10.09 20 439388 6280 55846379
Prescribed overdose 11.17 10.09 240 439168 22056 55830603
Endodontic procedure 11.15 10.09 49 439359 2887 55849772
Lymphopenia 11.04 10.09 81 439327 16693 55835966
Multiple drug therapy 11.01 10.09 4 439404 2788 55849871
Blood phosphorus decreased 11.01 10.09 9 439399 3988 55848671
Wrong product administered 11.00 10.09 17 439391 5655 55847004
Bone disorder 10.99 10.09 214 439194 19329 55833330
Nail injury 10.95 10.09 17 439391 522 55852137
Full blood count decreased 10.89 10.09 123 439285 23226 55829433
Therapeutic response unexpected 10.88 10.09 83 439325 16961 55835698
Throat tightness 10.87 10.09 117 439291 22290 55830369
Dialysis 10.85 10.09 39 439369 9663 55842996
Anterior chamber cleavage syndrome 10.84 10.09 10 439398 174 55852485
Nystagmus 10.79 10.09 18 439390 5807 55846852
Madarosis 10.77 10.09 4 439404 2749 55849910
Chronic graft versus host disease 10.76 10.09 6 439402 3250 55849409
Chronic obstructive pulmonary disease 10.68 10.09 354 439054 57061 55795598
Mental impairment 10.66 10.09 57 439351 12665 55839994
Hypocalcaemia 10.65 10.09 159 439249 28601 55824058
Abortion threatened 10.62 10.09 17 439391 536 55852123
Motor dysfunction 10.59 10.09 38 439370 9419 55843240
Application site pain 10.59 10.09 9 439399 3911 55848748
Immune thrombocytopenia 10.56 10.09 39 439369 9586 55843073
Serum ferritin increased 10.52 10.09 77 439331 5488 55847171
Bacteraemia 10.52 10.09 75 439333 15556 55837103
Diabetes insipidus 10.48 10.09 3 439405 2434 55850225
Breast cancer stage II 10.48 10.09 18 439390 5740 55846919
Retrognathia 10.47 10.09 15 439393 428 55852231
Hepatitis fulminant 10.45 10.09 6 439402 3198 55849461
Lupus vulgaris 10.44 10.09 36 439372 1893 55850766
Tendon disorder 10.43 10.09 76 439332 5409 55847250
Learning disorder 10.38 10.09 18 439390 607 55852052
Erythema 10.38 10.09 1062 438346 154877 55697782
Ear pain 10.36 10.09 174 439234 30716 55821943
Panniculitis 10.34 10.09 120 439288 9722 55842937
Metastases to lymph nodes 10.33 10.09 27 439381 7396 55845263
End stage renal disease 10.32 10.09 20 439388 6091 55846568
Abortion missed 10.31 10.09 32 439376 1592 55851067
Haematemesis 10.31 10.09 160 439248 28598 55824061
Adenovirus infection 10.26 10.09 7 439401 3401 55849258
Hepatic necrosis 10.25 10.09 16 439392 5300 55847359
Feeling hot 10.23 10.09 248 439160 41539 55811120
Device deployment issue 10.19 10.09 8 439400 3616 55849043
Hyperthermia 10.16 10.09 32 439376 8253 55844406

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Rheumatoid arthritis 499.44 10.16 838 146111 46971 31503424
Foetal exposure during pregnancy 340.16 10.16 649 146300 40227 31510168
Drug abuse 315.42 10.16 24 146925 87734 31462661
Arthralgia 250.90 10.16 1372 145577 150052 31400343
Toxicity to various agents 234.04 10.16 299 146650 181188 31369207
Completed suicide 211.20 10.16 80 146869 91434 31458961
Psoriatic arthropathy 163.21 10.16 314 146635 19569 31530826
Dysmorphism 137.40 10.16 114 146835 2958 31547437
Drug interaction 128.78 10.16 514 146435 208029 31342366
Joint swelling 128.05 10.16 539 146410 52892 31497503
Sickle cell anaemia with crisis 117.95 10.16 102 146847 2805 31547590
Premature baby 102.90 10.16 246 146703 17820 31532575
Musculoskeletal stiffness 92.17 10.16 408 146541 40917 31509478
Intentional overdose 90.82 10.16 39 146910 41350 31509045
Enthesopathy 89.67 10.16 105 146844 4182 31546213
Blood pressure fluctuation 83.88 10.16 264 146685 22472 31527923
Exposure during pregnancy 83.44 10.16 146 146803 8452 31541943
Tenosynovitis 79.68 10.16 98 146851 4112 31546283
Speech disorder developmental 76.13 10.16 69 146880 2022 31548373
Acute kidney injury 74.62 10.16 884 146065 278830 31271565
Synovitis 74.02 10.16 171 146778 12112 31538283
Neonatal respiratory distress syndrome 71.22 10.16 89 146860 3796 31546599
Pain 68.12 10.16 1230 145719 185529 31364866
Death 67.77 10.16 1221 145728 359348 31191047
Atrial septal defect 67.71 10.16 118 146831 6809 31543586
Hypospadias 64.64 10.16 76 146873 3040 31547355
Foetal anticonvulsant syndrome 64.32 10.16 49 146900 1120 31549275
Nasopharyngitis 63.47 10.16 506 146443 62739 31487656
Arthropathy 61.82 10.16 248 146701 23803 31526592
C-reactive protein abnormal 61.67 10.16 121 146828 7648 31542747
Suicide attempt 59.53 10.16 51 146898 37197 31513198
Maternal exposure during pregnancy 58.68 10.16 89 146860 4567 31545828
Maternal drugs affecting foetus 57.02 10.16 80 146869 3823 31546572
Product use in unapproved indication 56.99 10.16 251 146698 98920 31451475
Autism spectrum disorder 56.64 10.16 60 146889 2135 31548260
Small for dates baby 55.02 10.16 76 146873 3579 31546816
Arthritis 54.84 10.16 262 146687 27123 31523272
Overdose 53.82 10.16 206 146743 84458 31465937
Hypoglycaemia neonatal 53.78 10.16 53 146896 1729 31548666
Serotonin syndrome 53.30 10.16 11 146938 18762 31531633
Cryptorchism 52.50 10.16 55 146894 1932 31548463
Low birth weight baby 52.26 10.16 106 146843 6864 31543531
Drug reaction with eosinophilia and systemic symptoms 51.87 10.16 38 146911 29980 31520415
Hepatic function abnormal 51.87 10.16 69 146880 41153 31509242
Blood pressure systolic increased 51.83 10.16 203 146746 19267 31531128
Learning disorder 51.04 10.16 41 146908 1015 31549380
Psoriasis 49.74 10.16 379 146570 46340 31504055
Coma 49.64 10.16 71 146878 41079 31509316
Alanine aminotransferase abnormal 48.82 10.16 75 146874 3892 31546503
Ventricular septal defect 48.79 10.16 72 146877 3605 31546790
Drug resistance 48.49 10.16 24 146925 23429 31526966
Maternal exposure during breast feeding 48.49 10.16 47 146902 1502 31548893
Tongue disorder 48.43 10.16 85 146864 4932 31545463
Rhabdomyolysis 48.41 10.16 143 146806 63438 31486957
Febrile neutropenia 47.50 10.16 350 146599 121499 31428896
Rheumatoid nodule 46.90 10.16 60 146889 2621 31547774
Palmar-plantar erythrodysaesthesia syndrome 46.24 10.16 8 146941 15475 31534920
Foot deformity 44.95 10.16 74 146875 4075 31546320
Syndactyly 44.84 10.16 35 146914 830 31549565
Drug intolerance 43.61 10.16 400 146549 51633 31498762
Infusion related reaction 42.61 10.16 374 146575 47681 31502714
Drug dependence 42.49 10.16 26 146923 22553 31527842
Pulmonary fibrosis 42.18 10.16 171 146778 16489 31533906
Blood pressure diastolic abnormal 41.81 10.16 70 146879 3909 31546486
Developmental delay 40.47 10.16 55 146894 2550 31547845
Basal cell carcinoma 40.14 10.16 179 146770 18000 31532395
Osteoarthritis 39.32 10.16 184 146765 18883 31531512
Blood pressure systolic abnormal 38.89 10.16 59 146890 3028 31547367
Lower respiratory tract infection 38.89 10.16 244 146705 27993 31522402
Bradycardia 38.88 10.16 177 146772 69150 31481245
Tendonitis 37.86 10.16 106 146843 8452 31541943
C-reactive protein increased 37.29 10.16 367 146582 48283 31502112
Pancytopenia 37.19 10.16 590 146359 86726 31463669
Pain in extremity 37.03 10.16 750 146199 115453 31434942
Talipes 36.60 10.16 44 146905 1802 31548593
Exposure via breast milk 36.34 10.16 44 146905 1816 31548579
Joint laxity 36.20 10.16 23 146926 388 31550007
Blood pressure increased 36.18 10.16 544 146405 79089 31471306
Hand deformity 35.26 10.16 56 146893 2991 31547404
Disease progression 35.17 10.16 260 146689 90204 31460191
Haemoglobin decreased 34.84 10.16 724 146225 111951 31438444
Joint effusion 34.55 10.16 70 146879 4529 31545866
Renal failure 34.23 10.16 386 146563 122944 31427451
Angioedema 34.04 10.16 65 146884 33553 31516842
Respiratory arrest 34.00 10.16 43 146906 26214 31524181
Cardiac failure 33.91 10.16 246 146703 85707 31464688
Congenital hand malformation 33.05 10.16 25 146924 565 31549830
Multiple organ dysfunction syndrome 32.63 10.16 184 146765 68019 31482376
Jaundice neonatal 32.60 10.16 35 146914 1265 31549130
Peripheral swelling 32.54 10.16 468 146481 67397 31482998
Intellectual disability 32.44 10.16 34 146915 1195 31549200
Delirium 32.36 10.16 92 146857 41329 31509066
Blood pressure diastolic decreased 32.31 10.16 96 146853 7917 31542478
Heart rate decreased 32.17 10.16 233 146716 28033 31522362
Cytomegalovirus infection 31.44 10.16 41 146908 24666 31525729
Intentional product misuse 31.37 10.16 82 146867 37869 31512526
Hypermobility syndrome 31.34 10.16 20 146929 340 31550055
Foetal growth restriction 30.99 10.16 60 146889 3755 31546640
Plagiocephaly 30.82 10.16 23 146926 509 31549886
Language disorder 30.25 10.16 43 146906 2080 31548315
Polyarthritis 29.92 10.16 63 146886 4189 31546206
Knee arthroplasty 29.77 10.16 82 146867 6476 31543919
Somnolence 29.69 10.16 306 146643 99139 31451256
Psychotic disorder 29.40 10.16 36 146913 22257 31528138
Suicidal ideation 29.08 10.16 80 146869 36326 31514069
Drug withdrawal syndrome 28.37 10.16 27 146922 18723 31531672
Dysgraphia 27.90 10.16 42 146907 2141 31548254
Large for dates baby 27.85 10.16 27 146922 863 31549532
Altered state of consciousness 27.76 10.16 34 146915 21017 31529378
Astigmatism 27.37 10.16 29 146920 1032 31549363
Sedation 26.77 10.16 29 146920 18936 31531459
Selective eating disorder 26.24 10.16 36 146913 1684 31548711
Knee deformity 26.22 10.16 22 146927 580 31549815
Hyperbilirubinaemia neonatal 26.06 10.16 24 146925 718 31549677
Body temperature decreased 26.06 10.16 116 146833 11654 31538741
Depressed level of consciousness 25.77 10.16 92 146857 38509 31511886
Lactic acidosis 25.64 10.16 70 146879 31867 31518528
Hypotonia neonatal 25.63 10.16 31 146918 1278 31549117
Red blood cell sedimentation rate increased 25.53 10.16 91 146858 8255 31542140
Musculoskeletal pain 25.33 10.16 230 146719 29598 31520797
Hypoglycaemia 25.15 10.16 136 146813 50810 31499585
Pathogen resistance 24.90 10.16 5 146944 8696 31541699
Serum ferritin increased 24.90 10.16 71 146878 5721 31544674
Inflammation 24.78 10.16 201 146748 25040 31525355
Motor developmental delay 24.46 10.16 22 146927 638 31549757
Caesarean section 24.39 10.16 37 146912 1899 31548496
Cardiac arrest 24.20 10.16 280 146669 88782 31461613
Poisoning 24.08 10.16 9 146940 10382 31540013
Anal fistula 23.93 10.16 62 146887 4721 31545674
Constipation 23.74 10.16 418 146531 123573 31426822
Shock 23.61 10.16 43 146906 22602 31527793
Otitis media 23.56 10.16 43 146906 2573 31547822
Skin cancer 23.49 10.16 96 146853 9289 31541106
Loss of personal independence in daily activities 23.45 10.16 217 146732 28071 31522324
Grip strength decreased 23.21 10.16 43 146906 2603 31547792
Nasal disorder 23.06 10.16 34 146915 1701 31548694
Substance abuse 22.98 10.16 3 146946 7155 31543240
Drug withdrawal syndrome neonatal 22.58 10.16 50 146899 3442 31546953
Urticaria 22.49 10.16 165 146784 57352 31493043
Agitation 22.35 10.16 153 146796 54016 31496379
Diaphragmatic disorder 22.30 10.16 27 146922 1114 31549281
Off label use 22.27 10.16 1351 145598 345923 31204472
Weight decreased 22.27 10.16 930 146019 159022 31391373
Strabismus 22.11 10.16 32 146917 1574 31548821
Therapeutic product effect decreased 22.05 10.16 234 146715 31388 31519007
Vitamin D deficiency 21.98 10.16 69 146880 5863 31544532
Blood creatine phosphokinase increased 21.87 10.16 110 146839 41864 31508531
Dyspraxia 21.82 10.16 17 146932 402 31549993
Hyperglycaemia 21.74 10.16 91 146858 36385 31514010
Rash maculo-papular 21.69 10.16 55 146894 25664 31524731
Joint stiffness 21.62 10.16 98 146851 9923 31540472
Intentional self-injury 21.55 10.16 18 146931 13297 31537098
Acute hepatic failure 21.29 10.16 17 146932 12842 31537553
Hydrocele 20.99 10.16 35 146914 1948 31548447
Blood pressure diastolic increased 20.98 10.16 55 146894 4218 31546177
Blood parathyroid hormone decreased 20.67 10.16 28 146921 1294 31549101
Foetal disorder 20.65 10.16 22 146927 788 31549607
Dyslexia 20.61 10.16 15 146934 319 31550076
Poor venous access 20.53 10.16 53 146896 4027 31546368
Neuroleptic malignant syndrome 20.44 10.16 29 146920 16840 31533555
Umbilical hernia 20.44 10.16 54 146895 4160 31546235
Behaviour disorder 20.38 10.16 55 146894 4292 31546103
Agitation neonatal 20.15 10.16 25 146924 1058 31549337
Post procedural infection 19.98 10.16 56 146893 4467 31545928
Medical device implantation 19.76 10.16 19 146930 601 31549794
Arthritis bacterial 19.47 10.16 56 146893 4534 31545861
Red blood cell sedimentation rate 19.42 10.16 24 146925 1012 31549383
Wound 19.24 10.16 114 146835 12814 31537581
Radiation inflammation 19.23 10.16 18 146931 550 31549845
Vitamin B12 deficiency 19.05 10.16 47 146902 3472 31546923
Joint range of motion decreased 19.00 10.16 71 146878 6590 31543805
Congenital anomaly 18.96 10.16 27 146922 1308 31549087
Haematocrit decreased 18.92 10.16 218 146731 29843 31520552
Lacrimal disorder 18.79 10.16 14 146935 309 31550086
Patent ductus arteriosus 18.74 10.16 44 146905 3149 31547246
Cleft lip 18.68 10.16 14 146935 312 31550083
Congenital bladder anomaly 18.55 10.16 13 146936 260 31550135
Limb reduction defect 18.51 10.16 13 146936 261 31550134
Weight decrease neonatal 18.34 10.16 14 146935 321 31550074
Respiratory failure 18.16 10.16 346 146603 101103 31449292
Bronchiolitis 18.12 10.16 41 146908 2863 31547532
Cardiogenic shock 18.07 10.16 49 146900 22359 31528036
Respiratory disorder neonatal 18.03 10.16 28 146921 1467 31548928
Ear disorder 18.03 10.16 27 146922 1370 31549025
Infective pulmonary exacerbation of cystic fibrosis 18.00 10.16 4 146945 6480 31543915
Congenital foot malformation 17.92 10.16 15 146934 394 31550001
Multiple congenital abnormalities 17.91 10.16 17 146932 529 31549866
Malignant melanoma 17.86 10.16 77 146872 7630 31542765
Ear infection 17.79 10.16 85 146864 8796 31541599
Renal aplasia 17.78 10.16 19 146930 683 31549712
Spinal disorder 17.78 10.16 49 146900 3871 31546524
Granuloma skin 17.75 10.16 24 146925 1107 31549288
Finger deformity 17.73 10.16 25 146924 1200 31549195
Hallucination 17.73 10.16 134 146815 46276 31504119
Scoliosis 17.70 10.16 38 146911 2561 31547834
Infection 17.60 10.16 501 146448 81430 31468965
Tuberculosis 17.57 10.16 81 146868 8260 31542135
Ankyloglossia congenital 17.56 10.16 13 146936 284 31550111
Juvenile idiopathic arthritis 17.56 10.16 30 146919 1703 31548692
Oropharyngeal pain 17.50 10.16 223 146726 31260 31519135
Hepatic failure 17.44 10.16 85 146864 32617 31517778
Back disorder 17.42 10.16 65 146884 6028 31544367
Attention deficit hyperactivity disorder 17.42 10.16 36 146913 2362 31548033
Microcephaly 17.41 10.16 20 146929 780 31549615
Electrocardiogram QT prolonged 17.35 10.16 104 146845 37883 31512512
Haemangioma congenital 17.26 10.16 16 146933 483 31549912
Pyrexia 17.24 10.16 1195 145754 302645 31247750
Psychomotor retardation 17.15 10.16 43 146906 3209 31547186
Neck mass 17.08 10.16 28 146921 1536 31548859
Appendicolith 17.03 10.16 3 146946 5728 31544667
Oxygen saturation decreased 16.97 10.16 321 146628 48794 31501601
Haemangioma 16.95 10.16 30 146919 1752 31548643
Lung neoplasm malignant 16.89 10.16 131 146818 16099 31534296
Renal impairment 16.87 10.16 290 146659 86059 31464336
Plasma cell myeloma 16.84 10.16 174 146775 56357 31494038
Diabetic ketoacidosis 16.84 10.16 33 146916 16872 31533523
Neurotoxicity 16.75 10.16 31 146918 16195 31534200
C-reactive protein decreased 16.55 10.16 30 146919 1785 31548610
Proteinuria 16.46 10.16 33 146916 16730 31533665
Arthrodesis 16.39 10.16 15 146934 445 31549950
Venoocclusive liver disease 16.23 10.16 7 146942 7405 31542990
Bradycardia neonatal 16.21 10.16 21 146928 929 31549466
Foetal distress syndrome 16.09 10.16 22 146927 1026 31549369
Arnold-Chiari malformation 16.07 10.16 13 146936 325 31550070
Respiratory rate increased 16.07 10.16 85 146864 9160 31541235
Pectus excavatum 15.87 10.16 11 146938 216 31550179
No adverse event 15.76 10.16 43 146906 19582 31530813
Hypertelorism 15.65 10.16 16 146933 546 31549849
Anaphylactic shock 15.53 10.16 26 146923 14119 31536276
Hepatic enzyme increased 15.40 10.16 243 146706 35665 31514730
Oesophageal fibrosis 15.37 10.16 10 146939 176 31550219
Polydactyly 15.30 10.16 23 146926 1171 31549224
Gastrointestinal infection 15.25 10.16 53 146896 4747 31545648
Localised infection 15.22 10.16 122 146827 15143 31535252
Tooth malformation 15.13 10.16 10 146939 181 31550214
Foetal heart rate deceleration abnormality 15.13 10.16 15 146934 493 31549902
Septic arthritis staphylococcal 15.10 10.16 15 146934 494 31549901
Aggression 15.05 10.16 106 146843 37185 31513210
Immunodeficiency 14.97 10.16 52 146897 4657 31545738
Cholelithiasis 14.94 10.16 147 146802 19332 31531063
Maternal exposure timing unspecified 14.89 10.16 13 146936 362 31550033
Inguinal hernia 14.89 10.16 68 146881 6907 31543488
Malignant neoplasm progression 14.58 10.16 268 146681 78730 31471665
Crohn's disease 14.42 10.16 47 146902 4074 31546321
Cerebral haemorrhage 14.38 10.16 91 146858 32721 31517674
Blood folate decreased 14.28 10.16 17 146932 689 31549706
Hepatitis E antibody positive 14.27 10.16 11 146938 256 31550139
Incorrect route of product administration 14.21 10.16 20 146929 11653 31538742
Hernia pain 14.05 10.16 11 146938 262 31550133
Stevens-Johnson syndrome 14 10.16 38 146911 17334 31533061
Injection site pain 13.97 10.16 232 146717 34402 31515993
Product quality issue 13.94 10.16 34 146915 16077 31534318
Synovial cyst 13.84 10.16 30 146919 2035 31548360
Ankylosing spondylitis 13.81 10.16 59 146890 5822 31544573
Unresponsive to stimuli 13.79 10.16 67 146882 25733 31524662
Irritability 13.70 10.16 57 146892 22832 31527563
Haemolysis 13.69 10.16 68 146881 7148 31543247
Vascular insufficiency 13.60 10.16 12 146937 339 31550056
Spina bifida 13.52 10.16 12 146937 342 31550053
Vomiting 13.50 10.16 876 146073 223097 31327298
Arthritis infective 13.39 10.16 37 146912 2928 31547467
Blood insulin increased 13.37 10.16 12 146937 347 31550048
Second primary malignancy 13.36 10.16 8 146941 7024 31543371
Cellulitis 13.36 10.16 304 146645 47714 31502681
Hepatitis E virus test positive 13.30 10.16 11 146938 284 31550111
Anal atresia 13.30 10.16 11 146938 284 31550111
Nodule 13.30 10.16 57 146892 5633 31544762
Pharyngeal disorder 13.20 10.16 16 146933 661 31549734
Contraindicated product administered 13.17 10.16 145 146804 19627 31530768
Psychomotor skills impaired 13.12 10.16 38 146911 3089 31547306
Panniculitis 13.09 10.16 27 146922 1769 31548626
Respiratory depression 13.05 10.16 30 146919 14480 31535915
Pleural fibrosis 13.04 10.16 23 146926 1340 31549055
Developmental coordination disorder 12.97 10.16 9 146940 177 31550218
Emphysema 12.86 10.16 78 146871 8840 31541555
Wrong technique in product usage process 12.86 10.16 96 146853 33247 31517148
Ear malformation 12.86 10.16 11 146938 298 31550097
Injection site haemorrhage 12.81 10.16 79 146870 9006 31541389
Diverticular perforation 12.81 10.16 38 146911 3131 31547264
Maternal exposure before pregnancy 12.75 10.16 16 146933 685 31549710
Low set ears 12.75 10.16 13 146936 442 31549953
Asthma 12.75 10.16 131 146818 42480 31507915
Palindromic rheumatism 12.55 10.16 9 146940 187 31550208
Sexual dysfunction 12.50 10.16 6 146943 5962 31544433
Educational problem 12.50 10.16 14 146935 531 31549864
Peripheral artery thrombosis 12.46 10.16 30 146919 2182 31548213
Congenital hydronephrosis 12.43 10.16 16 146933 703 31549692
Gangrene neonatal 12.34 10.16 9 146940 192 31550203
Injection site bruising 12.31 10.16 71 146878 7904 31542491
Drug level increased 12.25 10.16 50 146899 20136 31530259
Respiratory tract infection viral 12.09 10.16 28 146921 1986 31548409
Neonatal seizure 12.08 10.16 13 146936 471 31549924
Pulmonary artery stenosis congenital 12.04 10.16 13 146936 473 31549922
Heart rate irregular 12.04 10.16 110 146839 14179 31536216
Progressive multifocal leukoencephalopathy 12.02 10.16 15 146934 9198 31541197
Hyperammonaemia 12.01 10.16 6 146943 5827 31544568
Tooth injury 11.98 10.16 20 146929 1114 31549281
Obsessive-compulsive disorder 11.91 10.16 4 146945 4933 31545462
Fine motor skill dysfunction 11.84 10.16 25 146924 1665 31548730
Neonatal infection 11.84 10.16 12 146937 405 31549990
Upper respiratory tract infection 11.83 10.16 197 146752 29225 31521170
Mobility decreased 11.82 10.16 186 146763 27283 31523112
Cholestasis 11.79 10.16 68 146881 25007 31525388
Meningeal disorder 11.78 10.16 11 146938 335 31550060
Blood test abnormal 11.75 10.16 58 146891 6083 31544312
Myoclonus 11.73 10.16 30 146919 13960 31536435
Kidney infection 11.66 10.16 49 146900 4801 31545594
Chronic graft versus host disease 11.62 10.16 3 146946 4389 31546006
Cystitis haemorrhagic 11.57 10.16 5 146944 5284 31545111
Acute chest syndrome 11.54 10.16 11 146938 344 31550051
Abnormal behaviour 11.54 10.16 64 146885 23764 31526631
Neutropenia neonatal 11.53 10.16 15 146934 666 31549729
Mouth ulceration 11.53 10.16 88 146861 10760 31539635
Excessive cerumen production 11.53 10.16 10 146939 276 31550119
Akathisia 11.50 10.16 10 146939 7243 31543152
Weight increased 11.45 10.16 482 146467 82465 31467930
Myopia 11.44 10.16 19 146930 1054 31549341
Gross motor delay 11.38 10.16 10 146939 281 31550114
Nephrolithiasis 11.34 10.16 184 146765 27155 31523240
Adenovirus infection 11.21 10.16 4 146945 4750 31545645
Osteonecrosis of jaw 11.18 10.16 41 146908 17030 31533365
Peritoneal dialysis complication 11.15 10.16 24 146925 1620 31548775
Steatorrhoea 11.14 10.16 15 146934 689 31549706
Folate deficiency 11.13 10.16 20 146929 1182 31549213
Sinusitis 11.06 10.16 235 146714 36461 31513934
Aspergillus infection 11.06 10.16 23 146926 11505 31538890
Anal fissure 11.01 10.16 38 146911 3391 31547004
Neck pain 10.97 10.16 158 146791 22752 31527643
Lung neoplasm 10.97 10.16 45 146904 4361 31546034
Hypertriglyceridaemia 10.92 10.16 12 146937 7786 31542609
Appendix disorder 10.92 10.16 14 146935 613 31549782
Cleft palate 10.90 10.16 14 146935 614 31549781
Latent tuberculosis 10.87 10.16 20 146929 1204 31549191
Nerve compression 10.86 10.16 34 146915 2884 31547511
BK virus infection 10.86 10.16 5 146944 5090 31545305
Foetal hypokinesia 10.81 10.16 11 146938 373 31550022
End stage renal disease 10.79 10.16 13 146936 8096 31542299
Hypermetropia 10.74 10.16 12 146937 454 31549941
Withdrawal syndrome 10.72 10.16 24 146925 11693 31538702
Ulna fracture 10.69 10.16 11 146938 378 31550017
Non-Hodgkin's lymphoma 10.69 10.16 23 146926 1552 31548843
Pancreatic duct stenosis 10.65 10.16 8 146941 179 31550216
PCO2 decreased 10.63 10.16 24 146925 1674 31548721
Enuresis 10.61 10.16 28 146921 2156 31548239
Metabolic acidosis 10.52 10.16 125 146824 39452 31510943
Suspected suicide 10.50 10.16 3 146946 4104 31546291
Oesophageal atresia 10.49 10.16 12 146937 466 31549929
Hypoxia 10.47 10.16 167 146782 50146 31500249
Hypokalaemia 10.43 10.16 180 146769 53394 31497001
Pleuritic pain 10.39 10.16 35 146914 3085 31547310
Pharyngitis 10.39 10.16 64 146885 7294 31543101
Acute graft versus host disease 10.36 10.16 8 146941 6145 31544250
Nail pitting 10.33 10.16 9 146940 250 31550145
Moaning 10.30 10.16 15 146934 742 31549653
Lung cancer metastatic 10.30 10.16 31 146918 2575 31547820
Blood lactic acid increased 10.28 10.16 8 146941 6122 31544273
Nose deformity 10.28 10.16 8 146941 189 31550206
Mean cell volume increased 10.27 10.16 33 146916 2839 31547556
Erectile dysfunction 10.25 10.16 50 146899 19185 31531210
Transfusion-related circulatory overload 10.24 10.16 9 146940 253 31550142
Fistula 10.22 10.16 53 146896 5668 31544727
Drug ineffective for unapproved indication 10.22 10.16 45 146904 17745 31532650
Back pain 10.18 10.16 612 146337 108801 31441594
Anti-erythropoietin antibody positive 10.17 10.16 16 146933 848 31549547

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Rheumatoid arthritis 1797.67 9.97 4902 435788 286903 70200851
Arthropathy 993.78 9.97 2592 438098 147465 70340289
Pemphigus 990.97 9.97 1819 438871 81217 70406537
Joint swelling 980.57 9.97 3627 437063 249584 70238170
Completed suicide 954.23 9.97 138 440552 226997 70260757
Systemic lupus erythematosus 948.42 9.97 2011 438679 99891 70387863
Hand deformity 944.47 9.97 1824 438866 84658 70403096
Synovitis 927.08 9.97 2301 438389 126927 70360827
Glossodynia 851.72 9.97 1747 438943 84740 70403014
Toxicity to various agents 826.35 9.97 697 439993 381475 70106279
Arthralgia 790.11 9.97 5589 435101 497801 69989953
Anti-cyclic citrullinated peptide antibody positive 728.23 9.97 1449 439241 68736 70419018
Infusion related reaction 719.77 9.97 2776 437914 194758 70292996
Wound 707.84 9.97 1758 438932 96974 70390780
Maternal exposure during pregnancy 706.31 9.97 1936 438754 113409 70374345
Pericarditis 696.66 9.97 1591 439099 83114 70404640
Drug abuse 676.22 9.97 66 440624 147190 70340564
Abdominal discomfort 591.35 9.97 2771 437919 211887 70275867
Pain 559.39 9.97 6164 434526 622652 69865102
Alopecia 542.76 9.97 2557 438133 195933 70291821
Therapeutic product effect decreased 542.14 9.97 2036 438654 140982 70346772
Swelling 537.00 9.97 2458 438232 186081 70301673
Discomfort 533.20 9.97 1653 439037 103783 70383971
Contraindicated product administered 504.11 9.97 1909 438781 132703 70355051
Drug intolerance 450.35 9.97 2665 438025 223022 70264732
Duodenal ulcer perforation 450.32 9.97 987 439703 50125 70437629
Drug interaction 449.41 9.97 1072 439618 380369 70107385
Helicobacter infection 447.11 9.97 1036 439654 54620 70433134
Nasopharyngitis 438.30 9.97 2616 438074 219590 70268164
Death 425.41 9.97 1680 439010 508381 69979373
Rheumatoid factor positive 423.41 9.97 932 439758 47468 70440286
Hepatic enzyme increased 416.31 9.97 2005 438685 154985 70332769
Musculoskeletal stiffness 413.60 9.97 1917 438773 145843 70341911
Intentional overdose 357.20 9.97 86 440604 98349 70389405
Exposure during pregnancy 342.40 9.97 1261 439429 86456 70401298
Acute kidney injury 331.20 9.97 1670 439020 472954 70014800
Impaired healing 301.94 9.97 1083 439607 73291 70414463
Psoriatic arthropathy 287.06 9.97 971 439719 63800 70423954
Febrile neutropenia 285.10 9.97 521 440169 203797 70283957
Treatment failure 274.40 9.97 1682 439008 142460 70345294
Hypersensitivity 271.60 9.97 2393 438297 227419 70260335
Sinusitis 266.62 9.97 1883 438807 167312 70320442
C-reactive protein abnormal 265.84 9.97 677 440013 37902 70449852
Muscle injury 260.58 9.97 671 440019 37823 70449931
Lower respiratory tract infection 258.36 9.97 1375 439315 110538 70377216
Peripheral swelling 254.54 9.97 2414 438276 234149 70253605
Folliculitis 245.02 9.97 699 439991 41871 70445883
Product use issue 243.05 9.97 1931 438759 178006 70309748
Irritable bowel syndrome 238.40 9.97 777 439913 50073 70437681
Cardiac arrest 226.12 9.97 404 440286 159430 70328324
Sleep disorder due to general medical condition, insomnia type 224.70 9.97 606 440084 35126 70452628
Overdose 222.65 9.97 449 440241 169296 70318458
Blister 221.80 9.97 1220 439470 99306 70388448
Red blood cell sedimentation rate abnormal 221.43 9.97 416 440274 18887 70468867
Depressed level of consciousness 210.89 9.97 142 440548 87289 70400465
Suicide attempt 210.09 9.97 116 440574 79394 70408360
Arthritis 203.52 9.97 1170 439520 96810 70390944
Blood pressure fluctuation 195.74 9.97 806 439884 58206 70429548
Knee arthroplasty 190.41 9.97 556 440134 33745 70454009
Weight increased 190.31 9.97 2322 438368 240009 70247745
Bradycardia 187.24 9.97 303 440387 124312 70363442
Osteoarthritis 182.83 9.97 928 439762 73219 70414535
Sickle cell anaemia with crisis 182.37 9.97 205 440485 5773 70481981
Hip arthroplasty 181.81 9.97 481 440209 27559 70460195
Drug ineffective 165.85 9.97 7274 433416 932478 69555276
Rhabdomyolysis 165.41 9.97 211 440479 95549 70392205
Pregnancy 164.53 9.97 418 440272 23363 70464391
Cardiac failure 161.93 9.97 412 440278 143129 70344625
Infection 161.68 9.97 2011 438679 208774 70278980
Respiratory arrest 157.13 9.97 69 440621 53864 70433890
Drug reaction with eosinophilia and systemic symptoms 157.12 9.97 82 440608 57931 70429823
Disease progression 155.75 9.97 478 440212 156194 70331560
Renal failure 155.04 9.97 626 440064 188444 70299310
Sedation 154.23 9.97 49 440641 46682 70441072
Malignant neoplasm progression 148.76 9.97 335 440355 121404 70366350
Lactic acidosis 145.86 9.97 114 440576 64910 70422844
Ill-defined disorder 142.64 9.97 696 439994 54045 70433709
Rheumatic fever 142.05 9.97 329 440361 17331 70470423
Constipation 140.07 9.97 955 439735 251483 70236271
Neutropenia 136.24 9.97 986 439704 256170 70231584
Red blood cell sedimentation rate increased 134.66 9.97 536 440154 38106 70449648
Sopor 133.48 9.97 18 440672 31249 70456505
Hepatic function abnormal 131.28 9.97 137 440553 67859 70419895
Abortion spontaneous 130.80 9.97 412 440278 26067 70461687
Serotonin syndrome 130.63 9.97 49 440641 42065 70445689
Blood pressure systolic increased 126.97 9.97 696 439994 56563 70431191
Hypotension 126.64 9.97 1760 438930 402621 70085133
Contusion 126.02 9.97 1283 439407 126753 70361001
Condition aggravated 123.14 9.97 3503 437187 424132 70063622
Multiple organ dysfunction syndrome 121.96 9.97 312 440378 108203 70379551
Respiratory failure 120.60 9.97 588 440102 168147 70319607
Blood pressure diastolic abnormal 118.35 9.97 283 440407 15221 70472533
Hyponatraemia 116.65 9.97 554 440136 159533 70328221
Swollen joint count increased 116.59 9.97 261 440429 13439 70474315
Fibromyalgia 115.77 9.97 596 440094 47278 70440476
Rash 114.94 9.97 4060 436630 506502 69981252
Drug dependence 114.79 9.97 44 440646 37277 70450477
Hypoglycaemia 114.19 9.97 261 440429 94103 70393651
Drug resistance 112.62 9.97 48 440642 38142 70449612
Agitation 109.99 9.97 262 440428 93113 70394641
Fatigue 109.20 9.97 6208 434482 818111 69669643
Joint effusion 109.10 9.97 274 440416 15203 70472551
Osteoporosis 108.79 9.97 595 440095 48312 70439442
Somnolence 107.37 9.97 841 439849 214765 70272989
Cytomegalovirus infection 106.48 9.97 57 440633 39701 70448053
Enthesopathy 106.21 9.97 219 440471 10650 70477104
Blood pressure systolic abnormal 105.49 9.97 242 440448 12667 70475087
Hepatic failure 104.75 9.97 122 440568 57503 70430251
Injection site erythema 104.65 9.97 794 439896 72130 70415624
C-reactive protein increased 103.79 9.97 1097 439593 109420 70378334
Grip strength decreased 103.65 9.97 271 440419 15414 70472340
Foot deformity 102.59 9.97 322 440368 20333 70467421
Electrocardiogram QT prolonged 100.24 9.97 232 440458 83285 70404469
Coma 99.44 9.97 269 440421 91575 70396179
Gastrointestinal disorder 99.25 9.97 1047 439643 104380 70383374
Renal impairment 98.04 9.97 510 440180 143427 70344327
Intentional self-injury 96.21 9.97 38 440652 31612 70456142
Rheumatoid nodule 95.18 9.97 256 440434 14811 70472943
Hyperglycaemia 94.55 9.97 160 440530 64512 70423242
Pain in extremity 94.46 9.97 2688 438002 325394 70162360
Blood pressure diastolic decreased 94.21 9.97 363 440327 25417 70462337
Inflammation 93.70 9.97 821 439869 77844 70409910
Stomatitis 93.31 9.97 1214 439476 127297 70360457
Product use in unapproved indication 92.59 9.97 833 439857 206645 70281109
Cardio-respiratory arrest 92.49 9.97 318 440372 100359 70387395
Live birth 89.96 9.97 237 440453 13542 70474212
Injection site pruritus 87.86 9.97 478 440212 38732 70449022
Musculoskeletal pain 87.83 9.97 903 439787 89424 70398330
Tenosynovitis 86.82 9.97 236 440454 13740 70474014
Plasma cell myeloma 85.73 9.97 206 440484 72995 70414759
Hypoxia 84.96 9.97 296 440394 93048 70394706
Bone erosion 84.25 9.97 246 440444 14927 70472827
Neoplasm progression 84.11 9.97 94 440596 45134 70442620
Disability assessment scale score increased 84.07 9.97 98 440592 2873 70484881
Intentional product misuse 81.82 9.97 239 440451 79356 70408398
Palmar-plantar erythrodysaesthesia syndrome 81.53 9.97 43 440647 30204 70457550
Device expulsion 81.53 9.97 19 440671 22227 70465527
Syncope 81.25 9.97 649 440041 165060 70322694
Tachycardia 80.98 9.97 614 440076 157932 70329822
Heart rate decreased 80.60 9.97 660 440030 61355 70426399
Joint stiffness 80.29 9.97 431 440259 34745 70453009
Altered state of consciousness 80.26 9.97 78 440612 39944 70447810
Poisoning 79.65 9.97 21 440669 22601 70465153
Injection site reaction 78.51 9.97 555 440135 49297 70438457
Cardiac failure congestive 77.79 9.97 507 440183 134950 70352804
Shock 77.41 9.97 82 440608 40343 70447411
Metabolic acidosis 75.15 9.97 225 440465 74121 70413633
Loss of personal independence in daily activities 74.24 9.97 831 439859 84079 70403675
Blood cholesterol increased 74.23 9.97 669 440021 63935 70423819
Drug withdrawal syndrome 73.82 9.97 57 440633 32658 70455096
Neuropathy peripheral 72.84 9.97 475 440215 126421 70361333
Disseminated intravascular coagulation 72.73 9.97 61 440629 33537 70454217
Respiratory depression 71.96 9.97 32 440658 24799 70462955
Pulmonary arterial hypertension 71.92 9.97 59 440631 32796 70454958
Thrombocytopenia 71.45 9.97 1050 439640 238060 70249694
Hyperhidrosis 71.33 9.97 501 440189 131085 70356669
Injection site pain 71.21 9.97 1076 439614 116543 70371211
Angioedema 70.68 9.97 197 440493 66413 70421341
Caesarean section 70.11 9.97 194 440496 11413 70476341
Seizure 69.49 9.97 738 439952 177224 70310530
Blood creatine phosphokinase increased 68.93 9.97 176 440514 61087 70426667
Tremor 68.02 9.97 628 440062 154996 70332758
Encephalopathy 67.95 9.97 179 440511 61482 70426272
Cholestasis 67.64 9.97 121 440569 47751 70440003
Joint laxity 67.60 9.97 78 440612 2261 70485493
Sedation complication 67.18 9.97 4 440686 13406 70474348
Cognitive disorder 67.14 9.97 177 440513 60779 70426975
Delirium 66.97 9.97 238 440452 74376 70413378
Intentional product use issue 66.62 9.97 1083 439607 119059 70368695
Blood pressure increased 66.52 9.97 1587 439103 186930 70300824
Psoriasis 66.13 9.97 917 439773 97516 70390238
Vomiting 65.91 9.97 3013 437677 590098 69897656
Joint range of motion decreased 65.71 9.97 328 440362 25698 70462056
Localised infection 65.59 9.97 391 440299 32767 70454987
Polyarthritis 65.19 9.97 180 440510 10576 70477178
Injection site swelling 64.22 9.97 474 440216 42683 70445071
Hyperkalaemia 63.74 9.97 394 440296 106197 70381557
Basal cell carcinoma 63.25 9.97 392 440298 33306 70454448
Pulmonary fibrosis 63.08 9.97 397 440293 33913 70453841
Mydriasis 62.88 9.97 12 440678 16141 70471613
Cerebral haemorrhage 62.74 9.97 152 440538 53712 70434042
Acute hepatic failure 62.71 9.97 48 440642 27624 70460130
Immune reconstitution inflammatory syndrome 61.81 9.97 5 440685 12985 70474769
Juvenile idiopathic arthritis 61.61 9.97 121 440569 5679 70482075
Gestational diabetes 61.11 9.97 123 440567 5878 70481876
Hallucination 60.27 9.97 256 440434 76004 70411750
Joint destruction 60.23 9.97 106 440584 4572 70483182
Asthma 60.16 9.97 471 440219 120322 70367432
Tendonitis 59.58 9.97 284 440406 21838 70465916
Tongue disorder 59.19 9.97 199 440491 13028 70474726
Disturbance in attention 58.31 9.97 111 440579 42783 70444971
Dehydration 58.22 9.97 1021 439669 225121 70262633
Neuroleptic malignant syndrome 57.81 9.97 46 440644 25961 70461793
Hypothermia 57.42 9.97 28 440662 20566 70467188
Femur fracture 57.32 9.97 403 440287 35729 70452025
Disability 57.24 9.97 214 440476 14769 70472985
Nodule 57.19 9.97 261 440429 19708 70468046
Myalgia 57.07 9.97 718 439972 167174 70320580
Diabetic ketoacidosis 56.96 9.97 67 440623 31445 70456309
Blood pressure diastolic increased 56.85 9.97 188 440502 12203 70475551
Anxiety 56.33 9.97 996 439694 219334 70268420
Body temperature decreased 56.01 9.97 337 440353 28335 70459419
Hepatocellular injury 55.33 9.97 128 440562 45963 70441791
Injection site bruising 54.49 9.97 414 440276 37618 70450136
Red blood cell sedimentation rate 54.06 9.97 104 440586 4806 70482948
Asthenia 54.05 9.97 2309 438381 455357 70032397
Myocardial infarction 53.98 9.97 746 439944 170899 70316855
Neutrophil count decreased 53.59 9.97 302 440388 83254 70404500
Ventricular tachycardia 53.34 9.97 90 440600 36333 70451421
Post transplant lymphoproliferative disorder 53.27 9.97 3 440687 10542 70477212
Mobility decreased 53.26 9.97 918 439772 102081 70385673
Cardiogenic shock 52.90 9.97 90 440600 36217 70451537
Diarrhoea 52.42 9.97 4174 436516 779167 69708587
Dyspnoea 52.02 9.97 4100 436590 765960 69721794
Orthostatic hypotension 51.99 9.97 157 440533 51586 70436168
Mental status changes 51.62 9.97 209 440481 62892 70424862
Abnormal behaviour 51.54 9.97 85 440605 34624 70453130
Laryngitis 51.50 9.97 194 440496 13437 70474317
Anaphylactic shock 50.67 9.97 77 440613 32413 70455341
Leukopenia 50.08 9.97 422 440268 106138 70381616
Hypokalaemia 50.00 9.97 547 440143 130641 70357113
Psychotic disorder 50.00 9.97 99 440591 37602 70450152
Alanine aminotransferase abnormal 49.97 9.97 136 440554 7923 70479831
Disorientation 49.84 9.97 188 440502 57735 70430019
Anaemia 49.80 9.97 2025 438665 401398 70086356
Ejection fraction decreased 48.85 9.97 72 440618 30690 70457064
Myoclonus 48.76 9.97 55 440635 26300 70461454
Respiratory distress 48.58 9.97 175 440515 54475 70433279
Ascites 48.44 9.97 235 440455 67312 70420442
Unresponsive to stimuli 48.38 9.97 163 440527 51768 70435986
Speech disorder 48.34 9.97 157 440533 50423 70437331
Oropharyngeal pain 48.22 9.97 854 439836 95456 70392298
Restlessness 48.18 9.97 120 440570 42008 70445746
Synovial cyst 47.83 9.97 141 440549 8601 70479153
Tenderness 47.80 9.97 259 440431 20951 70466803
Irritability 47.64 9.97 104 440586 38121 70449633
Ventricular fibrillation 47.56 9.97 59 440631 27052 70460702
Infective pulmonary exacerbation of cystic fibrosis 47.40 9.97 9 440681 12149 70475605
Drug level increased 47.31 9.97 97 440593 36372 70451382
Atrial fibrillation 47.22 9.97 833 439857 183515 70304239
Sepsis 47.01 9.97 1158 439532 243387 70244367
Nausea 46.64 9.97 4611 436079 847477 69640277
Adverse event 46.43 9.97 491 440199 48970 70438784
Neurotoxicity 46.21 9.97 71 440619 29755 70457999
Suicidal ideation 46.02 9.97 249 440441 69347 70418407
Venoocclusive liver disease 45.93 9.97 6 440684 10672 70477082
Blood glucose increased 44.80 9.97 416 440274 102566 70385188
Neck deformity 44.76 9.97 55 440635 1706 70486048
Maternal exposure before pregnancy 44.71 9.97 83 440607 3733 70484021
Melaena 44.64 9.97 189 440501 56166 70431588
Extrapyramidal disorder 44.51 9.97 38 440652 20712 70467042
Multiple sclerosis relapse 44.32 9.97 129 440561 42888 70444866
Fracture 43.91 9.97 242 440448 19702 70468052
Injection site rash 43.71 9.97 210 440480 16200 70471554
Substance abuse 43.61 9.97 5 440685 9832 70477922
Therapeutic response decreased 43.58 9.97 555 440135 57898 70429856
Skin ulcer 43.36 9.97 474 440216 47671 70440083
Multiple fractures 42.79 9.97 115 440575 6650 70481104
Ear infection 42.60 9.97 312 440378 28024 70459730
Aggression 42.49 9.97 156 440534 48290 70439464
Pathogen resistance 41.94 9.97 15 440675 13264 70474490
Posterior reversible encephalopathy syndrome 41.88 9.97 54 440636 24348 70463406
Latent tuberculosis 41.85 9.97 72 440618 3049 70484705
Pre-eclampsia 41.78 9.97 111 440579 6374 70481380
Pulmonary embolism 41.62 9.97 699 439991 155168 70332586
Arrhythmia 41.62 9.97 193 440497 55950 70431804
Torsade de pointes 41.59 9.97 31 440659 18085 70469669
Type 2 diabetes mellitus 41.57 9.97 438 440252 43642 70444112
Brain oedema 41.04 9.97 51 440639 23367 70464387
Cytokine release syndrome 41.01 9.97 63 440627 26404 70461350
Balance disorder 40.98 9.97 360 440330 89768 70397986
Herpes zoster 40.98 9.97 751 439939 84484 70403270
Proteinuria 40.82 9.97 75 440615 29299 70458455
Product quality issue 40.75 9.97 80 440610 30481 70457273
No adverse event 40.47 9.97 87 440603 32066 70455688
Accidental overdose 40.20 9.97 100 440590 35021 70452733
Joint dislocation 40.19 9.97 188 440502 14343 70473411
Poor venous access 40.17 9.97 192 440498 14779 70472975
Gastrointestinal haemorrhage 40.11 9.97 606 440084 136802 70350952
Premature delivery 40.09 9.97 248 440442 21056 70466698
Cerebral infarction 40.06 9.97 135 440555 42874 70444880
Psychomotor hyperactivity 40.06 9.97 23 440667 15410 70472344
Exostosis 39.97 9.97 186 440504 14159 70473595
Vision blurred 39.90 9.97 387 440303 94597 70393157
Premature rupture of membranes 39.81 9.97 80 440610 3818 70483936
Asphyxia 39.59 9.97 8 440682 10334 70477420
Dizziness 39.54 9.97 2421 438269 461720 70026034
Inappropriate antidiuretic hormone secretion 39.44 9.97 52 440638 23224 70464530
Blood creatinine increased 39.27 9.97 638 440052 142363 70345391
Agranulocytosis 39.26 9.97 124 440566 40174 70447580
Aspergillus infection 39.22 9.97 32 440658 17836 70469918
Fluid retention 39.09 9.97 232 440458 63153 70424601
Premature labour 39.07 9.97 124 440566 7876 70479878
Joint injury 39.05 9.97 294 440396 26638 70461116
Limb deformity 38.90 9.97 74 440616 3391 70484363
Withdrawal syndrome 38.86 9.97 59 440631 24845 70462909
Creatinine renal clearance decreased 38.76 9.97 30 440660 17170 70470584
Neck mass 38.17 9.97 82 440608 4104 70483650
Depression 38.01 9.97 943 439747 198031 70289723
Blood parathyroid hormone decreased 37.96 9.97 133 440557 8891 70478863
Rash maculo-papular 37.92 9.97 173 440517 50372 70437382
Fear of injection 37.84 9.97 109 440581 6563 70481191
Maternal exposure timing unspecified 37.75 9.97 84 440606 4307 70483447
Bronchopulmonary aspergillosis 37.59 9.97 45 440645 20957 70466797
Second primary malignancy 37.53 9.97 17 440673 13034 70474720
Drug ineffective for unapproved indication 37.26 9.97 119 440571 38419 70449335
Loss of consciousness 37.25 9.97 712 439978 155004 70332750
Smear cervix abnormal 37.14 9.97 59 440631 2337 70485417
Akathisia 36.97 9.97 15 440675 12278 70475476
Pulmonary oedema 36.81 9.97 330 440360 81948 70405806
Miosis 36.62 9.97 21 440669 14080 70473674
Drug use disorder 36.49 9.97 4 440686 8147 70479607
Bursitis 36.35 9.97 287 440403 26386 70461368
Coagulopathy 36.27 9.97 97 440593 33152 70454602
Transplant rejection 35.76 9.97 36 440654 18135 70469619
Status epilepticus 35.55 9.97 61 440629 24465 70463289
Gamma-glutamyltransferase increased 35.38 9.97 178 440512 50507 70437247
Eosinophilia 35.25 9.97 130 440560 40189 70447565
Decreased appetite 35.23 9.97 1541 439149 303239 70184515
Coronary artery disease 34.90 9.97 237 440453 62499 70425255
Lupus-like syndrome 34.85 9.97 153 440537 11362 70476392
Tachypnoea 34.80 9.97 79 440611 28559 70459195
Granuloma skin 34.75 9.97 116 440574 7566 70480188
Subdural haematoma 34.65 9.97 82 440608 29216 70458538
Haematotoxicity 34.61 9.97 21 440669 13653 70474101
Thrombotic microangiopathy 34.40 9.97 36 440654 17812 70469942
Wheelchair user 34.36 9.97 90 440600 5124 70482630
Tuberculosis 33.93 9.97 182 440508 14666 70473088
Acute respiratory failure 33.85 9.97 195 440495 53470 70434284
Urticaria 33.84 9.97 763 439927 162286 70325468
Cerebrovascular accident 33.70 9.97 658 440032 142812 70344942
White blood cell count decreased 33.68 9.97 802 439888 169339 70318415
Platelet count decreased 33.67 9.97 846 439844 177376 70310378
Colorectal cancer 33.60 9.97 6 440684 8464 70479290
Arthritis infective 33.59 9.97 112 440578 7300 70480454
Immunodeficiency 33.44 9.97 205 440485 17350 70470404
Acute graft versus host disease 33.43 9.97 9 440681 9553 70478201
Dystonia 33.41 9.97 44 440646 19662 70468092
Oral herpes 33.38 9.97 261 440429 23925 70463829
Deep vein thrombosis 33.34 9.97 487 440203 110555 70377199
Unintentional medical device removal 33.19 9.97 3 440687 7121 70480633
Mouth ulceration 33.18 9.97 343 440347 34006 70453748
Foot fracture 33.10 9.97 222 440468 19378 70468376
Haemoptysis 32.97 9.97 186 440504 51266 70436488
Graft versus host disease 32.85 9.97 27 440663 14996 70472758
Tenosynovitis stenosans 32.84 9.97 55 440635 2278 70485476
Osteonecrosis of jaw 32.79 9.97 137 440553 40865 70446889
Bone disorder 32.53 9.97 203 440487 17287 70470467
Product administration error 32.30 9.97 86 440604 29437 70458317
Blood alkaline phosphatase increased 32.09 9.97 222 440468 58299 70429455
Chronic kidney disease 31.84 9.97 235 440455 60822 70426932
Bradyphrenia 31.81 9.97 11 440679 9935 70477819
Emotional distress 31.80 9.97 121 440569 37067 70450687
Spinal stenosis 31.73 9.97 177 440513 14476 70473278
Forced expiratory volume decreased 31.72 9.97 4 440686 7310 70480444
Panniculitis 31.67 9.97 141 440549 10535 70477219
Joint noise 31.05 9.97 67 440623 3364 70484390
Blood bilirubin increased 31.02 9.97 231 440459 59670 70428084
Wrong technique in product usage process 30.96 9.97 275 440415 68423 70419331
BK virus infection 30.96 9.97 6 440684 7983 70479771
Fear 30.86 9.97 51 440639 20760 70466994
Ulcer 30.76 9.97 269 440421 25485 70462269
Ischaemic stroke 30.62 9.97 94 440596 30726 70457028
Clostridium difficile colitis 30.57 9.97 86 440604 28910 70458844
Dysarthria 30.54 9.97 244 440446 62069 70425685
Mania 30.52 9.97 37 440653 17137 70470617
Gastroenteritis viral 30.42 9.97 233 440457 21222 70466532
Rotator cuff repair 30.33 9.97 44 440646 1607 70486147
Acute myeloid leukaemia 30.29 9.97 95 440595 30845 70456909
Bronchitis 30.24 9.97 948 439742 116295 70371459
Erythema multiforme 30.17 9.97 35 440655 16529 70471225
Stevens-Johnson syndrome 29.95 9.97 118 440572 35789 70451965
Acute respiratory distress syndrome 29.88 9.97 143 440547 41111 70446643
Retinitis 29.69 9.97 74 440616 4086 70483668
Lip dry 29.60 9.97 130 440560 9655 70478099
Pleural effusion 29.52 9.97 615 440075 132249 70355505
Skin papilloma 29.39 9.97 87 440603 5319 70482435
Tumour lysis syndrome 29.27 9.97 55 440635 21305 70466449
Synovial fluid analysis 28.94 9.97 46 440644 1823 70485931
Hallucination, visual 28.77 9.97 90 440600 29247 70458507
Peripheral venous disease 28.63 9.97 137 440553 10550 70477204
Leukocytosis 28.44 9.97 138 440552 39530 70448224
Hypertransaminasaemia 28.42 9.97 10 440680 8933 70478821
Skin cancer 28.31 9.97 162 440528 13374 70474380
Shock haemorrhagic 28.15 9.97 43 440647 18063 70469691
Haemorrhage intracranial 28.00 9.97 71 440619 24706 70463048
Pulmonary hypertension 27.81 9.97 172 440518 46364 70441390
Loose body in joint 27.81 9.97 37 440653 1244 70486510
Acute chest syndrome 27.67 9.97 32 440658 930 70486824
Acute generalised exanthematous pustulosis 27.55 9.97 33 440657 15364 70472390
Hyperthermia 27.48 9.97 38 440652 16633 70471121
Facet joint syndrome 27.38 9.97 92 440598 6021 70481733
Aphasia 27.36 9.97 157 440533 43092 70444662
Pancytopenia 27.32 9.97 1174 439516 149933 70337821
Anaphylactic reaction 27.22 9.97 316 440374 74658 70413096
Dyskinesia 27.13 9.97 147 440543 40927 70446827
Face oedema 27.06 9.97 76 440614 25563 70462191
Dysgeusia 27.04 9.97 188 440502 49314 70438440
Jaundice 27.03 9.97 191 440499 49917 70437837
Bronchospasm 26.79 9.97 64 440626 22728 70465026
Injection site warmth 26.68 9.97 162 440528 13663 70474091
Respiratory disorder 26.40 9.97 139 440551 38984 70448770
Influenza 26.40 9.97 908 439782 112792 70374962
Aspartate aminotransferase increased 26.40 9.97 594 440096 126384 70361370
Pulmonary alveolar haemorrhage 26.14 9.97 16 440674 10353 70477401
Pneumatosis intestinalis 26.08 9.97 3 440687 5884 70481870
Angina pectoris 25.82 9.97 185 440505 48198 70439556
Chest discomfort 25.82 9.97 582 440108 123799 70363955
Cardiac failure acute 25.80 9.97 43 440647 17444 70470310
Fracture delayed union 25.66 9.97 46 440644 2013 70485741
Pancreatitis acute 25.57 9.97 170 440520 45054 70442700
Surgery 25.52 9.97 292 440398 29697 70458057
Scleritis 25.40 9.97 64 440626 3558 70484196
Haemorrhage 25.36 9.97 367 440323 83448 70404306
Malignant melanoma 25.03 9.97 160 440530 13740 70474014
Bone pain 24.90 9.97 199 440491 50623 70437131
Appendicolith 24.90 9.97 3 440687 5677 70482077
Dislocation of vertebra 24.90 9.97 77 440613 4823 70482931
Respiration abnormal 24.88 9.97 6 440684 6858 70480896
Haemophagocytic lymphohistiocytosis 24.73 9.97 53 440637 19559 70468195
Nightmare 24.65 9.97 64 440626 22092 70465662
Dyspnoea exertional 24.59 9.97 341 440349 78089 70409665
Foetal death 24.58 9.97 90 440600 6149 70481605
Blood calcium decreased 24.57 9.97 94 440596 28752 70459002
Potentiating drug interaction 24.49 9.97 10 440680 8154 70479600
Polyneuropathy 24.49 9.97 61 440629 21354 70466400
Flushing 24.45 9.97 361 440329 81811 70405943
Acute graft versus host disease in skin 24.42 9.97 7 440683 7130 70480624
Hallucination, auditory 24.41 9.97 48 440642 18280 70469474
Drug tolerance decreased 24.17 9.97 123 440567 9710 70478044
Adenovirus infection 24.15 9.97 9 440681 7759 70479995
Schizophrenia 24.03 9.97 42 440648 16726 70471028
Delusion 24.00 9.97 52 440638 19113 70468641
Dysphagia 23.98 9.97 526 440164 112308 70375446
Vertigo 23.93 9.97 261 440429 62382 70425372
Blood pressure decreased 23.90 9.97 412 440278 91103 70396651
Post procedural infection 23.72 9.97 127 440563 10226 70477528
Endophthalmitis 23.61 9.97 5 440685 6250 70481504
Pyrexia 23.46 9.97 3360 437330 603592 69884162
Cytopenia 23.39 9.97 45 440645 17278 70470476
Acidosis 23.33 9.97 49 440641 18214 70469540
Cyst 23.27 9.97 147 440543 12572 70475182
Polyhydramnios 23.23 9.97 37 440653 1469 70486285
Oxygen saturation decreased 23.20 9.97 914 439776 115515 70372239
Cytomegalovirus viraemia 23.17 9.97 23 440667 11662 70476092
Metastases to bone 23.12 9.97 67 440623 22309 70465445
Muscle spasms 23.07 9.97 755 439935 153291 70334463
Hepatitis B reactivation 23.05 9.97 3 440687 5352 70482402
Hepatic encephalopathy 23.02 9.97 66 440624 22052 70465702
Anti-cyclic citrullinated peptide antibody 22.89 9.97 59 440631 3326 70484428
Sciatica 22.89 9.97 244 440446 24383 70463371
Glycosylated haemoglobin increased 22.77 9.97 46 440644 17345 70470409
Affective disorder 22.70 9.97 9 440681 7470 70480284
Toxic skin eruption 22.61 9.97 58 440632 20104 70467650
Sinus tachycardia 22.60 9.97 121 440569 33792 70453962
Hemiplegia 22.58 9.97 32 440658 13863 70473891
Rhinorrhoea 22.55 9.97 556 440134 65815 70421939
Stress cardiomyopathy 22.48 9.97 17 440673 9845 70477909
Urinary retention 22.47 9.97 213 440477 52307 70435447
Hyperuricaemia 22.42 9.97 21 440669 10945 70476809
Pancreatitis 22.41 9.97 265 440425 62403 70425351
Antinuclear antibody positive 22.39 9.97 93 440597 6740 70481014
Toxic epidermal necrolysis 22.22 9.97 149 440541 39408 70448346
Febrile bone marrow aplasia 22.21 9.97 25 440665 11966 70475788
Cyanosis 22.19 9.97 72 440618 23134 70464620
Device use error 22.13 9.97 7 440683 6689 70481065
Adjustment disorder with depressed mood 22.05 9.97 67 440623 4156 70483598
Tubulointerstitial nephritis 22.05 9.97 118 440572 32958 70454796
Cystitis haemorrhagic 22.03 9.97 13 440677 8580 70479174
Postoperative wound infection 21.97 9.97 133 440557 11205 70476549
Device difficult to use 21.92 9.97 21 440669 10828 70476926
Pain in jaw 21.88 9.97 165 440525 42504 70445250
Anhedonia 21.86 9.97 34 440656 14179 70473575
Muscle spasticity 21.81 9.97 57 440633 19632 70468122
Nocardiosis 21.78 9.97 3 440687 5126 70482628
Malignant mediastinal neoplasm 21.71 9.97 27 440663 848 70486906
Anuria 21.69 9.97 57 440633 19596 70468158
Hypomagnesaemia 21.68 9.97 156 440534 40608 70447146
Polyuria 21.66 9.97 31 440659 13375 70474379
Hyperbilirubinaemia 21.60 9.97 70 440620 22498 70465256
Lymphocyte count decreased 21.56 9.97 170 440520 43369 70444385
Tardive dyskinesia 21.52 9.97 18 440672 9911 70477843
Incorrect route of product administration 21.50 9.97 88 440602 26404 70461350
Muscle rigidity 21.42 9.97 53 440637 18597 70469157
Cushingoid 21.38 9.97 106 440584 8282 70479472
Exposure to toxic agent 21.34 9.97 6 440684 6188 70481566
Klebsiella infection 21.22 9.97 35 440655 14257 70473497
Synovial disorder 21.15 9.97 30 440660 1073 70486681
Musculoskeletal disorder 21.02 9.97 203 440487 19768 70467986
Blood lactic acid increased 21.02 9.97 23 440667 11150 70476604
Metastases to liver 20.98 9.97 86 440604 25792 70461962
International normalised ratio increased 20.90 9.97 364 440326 80362 70407392
Breast cancer stage I 20.85 9.97 6 440684 6096 70481658
Epstein-Barr virus infection 20.85 9.97 31 440659 13167 70474587
Chronic graft versus host disease 20.79 9.97 8 440682 6762 70480992
Acute myocardial infarction 20.73 9.97 323 440367 72564 70415190
Dactylitis 20.66 9.97 44 440646 2189 70485565
Hypervolaemia 20.62 9.97 153 440537 39553 70448201
Interstitial lung disease 20.56 9.97 494 440196 104191 70383563
Disease recurrence 20.44 9.97 143 440547 37460 70450294
Oliguria 20.41 9.97 39 440651 15012 70472742
Hepatocellular carcinoma 20.34 9.97 20 440670 10188 70477566
Polydipsia 20.26 9.97 6 440684 5982 70481772
Progressive multifocal leukoencephalopathy 20.25 9.97 57 440633 19157 70468597
Rebound effect 20.17 9.97 6 440684 5965 70481789
Endodontic procedure 20.11 9.97 47 440643 2490 70485264
Rheumatoid lung 20.09 9.97 57 440633 3402 70484352
Haematoma 20.02 9.97 198 440492 48220 70439534
Ileus 19.99 9.97 80 440610 24157 70463597
Pulseless electrical activity 19.96 9.97 32 440658 13183 70474571
Bacteraemia 19.85 9.97 104 440586 29205 70458549
Septic shock 19.84 9.97 538 440152 111720 70376034
Breast feeding 19.74 9.97 23 440667 674 70487080
Pharyngitis streptococcal 19.71 9.97 113 440577 9335 70478419
Pleuritic pain 19.61 9.97 108 440582 8789 70478965
Foetal distress syndrome 19.57 9.97 19 440671 449 70487305
Stillbirth 19.52 9.97 60 440630 3745 70484009
Human antichimeric antibody positive 19.49 9.97 34 440656 1456 70486298
Cardiac failure chronic 19.47 9.97 21 440669 10248 70477506
Hyperthyroidism 19.45 9.97 62 440628 20029 70467725
Wound infection 19.30 9.97 180 440510 17362 70470392
Myelosuppression 19.30 9.97 109 440581 30036 70457718
Ingrown hair 19.28 9.97 22 440668 630 70487124
Hyperlactacidaemia 19.26 9.97 4 440686 5068 70482686
Hemiparesis 18.97 9.97 116 440574 31353 70456401
Pulmonary congestion 18.92 9.97 86 440604 25068 70462686
Atrioventricular block 18.90 9.97 31 440659 12657 70475097
Sexual dysfunction 18.75 9.97 9 440681 6672 70481082
Acute coronary syndrome 18.72 9.97 63 440627 20016 70467738
Electrocardiogram QRS complex prolonged 18.65 9.97 20 440670 9786 70477968
Peripheral sensory neuropathy 18.60 9.97 29 440661 12081 70475673
Catatonia 18.56 9.97 14 440676 8119 70479635
Hyperammonaemia 18.48 9.97 22 440668 10271 70477483
Enterocolitis 18.48 9.97 33 440657 13033 70474721
Visual acuity reduced 18.42 9.97 100 440590 27830 70459924
Renal injury 18.28 9.97 46 440644 16048 70471706
Hepatitis fulminant 18.27 9.97 9 440681 6572 70481182
Sinus bradycardia 18.23 9.97 80 440610 23543 70464211
Cardiomyopathy 18.19 9.97 93 440597 26280 70461474
Pseudomonas infection 18.12 9.97 59 440631 18935 70468819
Chest pain 18.08 9.97 1330 439360 249930 70237824
Pulmonary haemorrhage 18.05 9.97 36 440654 13637 70474117
Palpitations 17.99 9.97 537 440153 110216 70377538
Muscle twitching 17.95 9.97 63 440627 19764 70467990
Heart rate irregular 17.95 9.97 272 440418 29471 70458283
Weight decreased 17.88 9.97 2197 438493 308291 70179463
Labelled drug-drug interaction medication error 17.84 9.97 83 440607 24044 70463710
Therapy non-responder 17.79 9.97 614 440076 76301 70411453
Hyperprolactinaemia 17.78 9.97 3 440687 4410 70483344
Spinal disorder 17.77 9.97 108 440582 9112 70478642
Lipase increased 17.77 9.97 43 440647 15203 70472551
End stage renal disease 17.73 9.97 26 440664 11107 70476647
Induced labour 17.62 9.97 24 440666 826 70486928
Paralysis 17.52 9.97 30 440660 12042 70475712
Haematocrit decreased 17.51 9.97 473 440217 56785 70430969
Myocarditis 17.49 9.97 59 440631 18734 70469020
Right ventricular failure 17.45 9.97 75 440615 22199 70465555
Onychomycosis 17.44 9.97 87 440603 6814 70480940
Obesity 17.40 9.97 248 440442 26523 70461231
Respiratory acidosis 17.39 9.97 23 440667 10258 70477496
Skin necrosis 17.34 9.97 166 440524 16125 70471629
Gastric haemorrhage 17.34 9.97 39 440651 14146 70473608
Dermatitis acneiform 17.29 9.97 18 440672 8927 70478827
Upper respiratory tract infection 17.14 9.97 628 440062 78646 70409108
Body height below normal 17.14 9.97 37 440653 1858 70485896
Foetal exposure during pregnancy 17.08 9.97 75 440615 5570 70482184
Metastases to central nervous system 17.05 9.97 43 440647 14991 70472763
Lacrimal disorder 17.00 9.97 18 440672 473 70487281
Alanine aminotransferase increased 16.95 9.97 746 439944 146734 70341020
Haemorrhage in pregnancy 16.93 9.97 30 440660 1301 70486453
Deep vein thrombosis postoperative 16.79 9.97 55 440635 3552 70484202
Hypophosphataemia 16.79 9.97 49 440641 16277 70471477
Placental disorder 16.76 9.97 24 440666 866 70486888
Frequent bowel movements 16.69 9.97 203 440487 20950 70466804
Ankle arthroplasty 16.68 9.97 28 440662 1162 70486592
Nephropathy toxic 16.64 9.97 59 440631 18455 70469299
Device leakage 16.60 9.97 20 440670 9288 70478466
Hepatitis acute 16.57 9.97 39 440651 13923 70473831
Ileus paralytic 16.52 9.97 18 440672 8743 70479011
Hypoalbuminaemia 16.49 9.97 62 440628 19060 70468694
Cholangitis 16.49 9.97 29 440661 11520 70476234
Tuberculin test positive 16.48 9.97 51 440639 3195 70484559
Presyncope 16.37 9.97 151 440539 37287 70450467
Off label use 16.32 9.97 4236 436454 738824 69748930
Paranoia 16.28 9.97 54 440636 17234 70470520
Persecutory delusion 16.27 9.97 4 440686 4513 70483241
Ankylosing spondylitis 16.25 9.97 126 440564 11520 70476234
Tooth disorder 16.06 9.97 223 440467 23715 70464039
Dry eye 16.06 9.97 286 440404 31996 70455758
Erectile dysfunction 16.00 9.97 38 440652 13524 70474230
Finger deformity 15.96 9.97 78 440612 6058 70481696
Coordination abnormal 15.96 9.97 49 440641 16017 70471737
Mass 15.94 9.97 161 440529 15865 70471889
Feeling abnormal 15.92 9.97 722 439968 141597 70346157
Sickle cell anaemia 15.91 9.97 20 440670 635 70487119
Temperature regulation disorder 15.88 9.97 4 440686 4440 70483314
Multiple sclerosis 15.88 9.97 92 440598 25193 70462561
Metastases to lung 15.86 9.97 51 440639 16433 70471321
Foot operation 15.83 9.97 66 440624 4791 70482963
Myocardial ischaemia 15.76 9.97 87 440603 24113 70463641
Alcohol abuse 15.74 9.97 6 440684 5101 70482653
Hepatotoxicity 15.73 9.97 186 440504 43800 70443954
Tooth infection 15.71 9.97 164 440526 16299 70471455
Lymphatic fistula 15.70 9.97 22 440668 778 70486976
Myopathy 15.63 9.97 61 440629 18551 70469203
Wound infection pseudomonas 15.57 9.97 32 440658 1552 70486202
Troponin increased 15.57 9.97 52 440638 16562 70471192
Femoral hernia incarcerated 15.55 9.97 22 440668 785 70486969
Anger 15.46 9.97 50 440640 16082 70471672
Joint lock 15.42 9.97 47 440643 2920 70484834
Immune effector cell-associated neurotoxicity syndrome 15.39 9.97 3 440687 3975 70483779
Lethargy 15.36 9.97 353 440337 74897 70412857
Hepatitis cholestatic 15.28 9.97 35 440655 12615 70475139
Deformity 15.24 9.97 96 440594 8201 70479553
Atrioventricular block complete 15.24 9.97 46 440644 15117 70472637
Pneumothorax 15.20 9.97 96 440594 25750 70462004
Injection site urticaria 15.19 9.97 124 440566 11514 70476240
Pulmonary tuberculosis 15.19 9.97 92 440598 7753 70480001
Graft versus host disease in skin 15.18 9.97 8 440682 5622 70482132
Amylase increased 15.15 9.97 25 440665 10183 70477571
Intracranial pressure increased 15.14 9.97 14 440676 7342 70480412
Cytomegalovirus chorioretinitis 15.08 9.97 7 440683 5291 70482463
Lung transplant 15.07 9.97 4 440686 4286 70483468
Mental disorder 15.06 9.97 108 440582 28132 70459622
Hypothyroidism 15.04 9.97 197 440493 45558 70442196
Purpura 15.04 9.97 59 440631 17916 70469838
Hepatitis C 15.02 9.97 36 440654 12771 70474983
Toxic encephalopathy 14.97 9.97 26 440664 10380 70477374
Coronary arterial stent insertion 14.96 9.97 9 440681 5878 70481876
Aphthous ulcer 14.95 9.97 148 440542 14508 70473246
Incoherent 14.93 9.97 14 440676 7292 70480462
Normal newborn 14.93 9.97 78 440612 6222 70481532
Hypernatraemia 14.87 9.97 36 440654 12725 70475029
Radiation inflammation 14.86 9.97 18 440672 550 70487204
COVID-19 pneumonia 14.85 9.97 78 440612 21891 70465863
Drug abuser 14.85 9.97 9 440681 5855 70481899
Injection site haemorrhage 14.85 9.97 232 440458 25295 70462459
Dyslipidaemia 14.77 9.97 24 440666 9836 70477918
Placental insufficiency 14.75 9.97 25 440665 1046 70486708
Drug screen positive 14.74 9.97 9 440681 5831 70481923
Cardiotoxicity 14.74 9.97 29 440661 11041 70476713
Abdominal distension 14.73 9.97 517 440173 104152 70383602
Haemoglobin decreased 14.73 9.97 1473 439217 203686 70284068
Tooth abscess 14.72 9.97 147 440543 14442 70473312
Acute lymphocytic leukaemia recurrent 14.72 9.97 6 440684 4898 70482856
Generalised oedema 14.72 9.97 77 440613 21631 70466123
Spinal osteoarthritis 14.70 9.97 153 440537 15195 70472559
Virologic failure 14.69 9.97 3 440687 3847 70483907
Cervical incompetence 14.62 9.97 17 440673 497 70487257
Accidental exposure to product 14.61 9.97 108 440582 27943 70459811
Product prescribing error 14.60 9.97 163 440527 38789 70448965
Red blood cell count decreased 14.58 9.97 426 440264 51735 70436019
Heparin-induced thrombocytopenia 14.50 9.97 21 440669 9016 70478738
Peritoneal dialysis complication 14.49 9.97 39 440651 2257 70485497
Haematuria 14.49 9.97 293 440397 63280 70424474
General physical health deterioration 14.48 9.97 1677 439013 234354 70253400
Knee operation 14.48 9.97 66 440624 4981 70482773
Glomerular filtration rate decreased 14.42 9.97 73 440617 20683 70467071
Transplant dysfunction 14.40 9.97 13 440677 6896 70480858
Bradypnoea 14.36 9.97 8 440682 5451 70482303
Immunosuppression 14.23 9.97 121 440569 11371 70476383
Prostatic specific antigen increased 14.22 9.97 23 440667 9443 70478311
Lip swelling 14.19 9.97 139 440551 33915 70453839
Bone density abnormal 14.18 9.97 45 440645 2858 70484896
Bladder cancer 14.17 9.97 57 440633 17185 70470569
Toothache 14.16 9.97 176 440514 18254 70469500
Taste disorder 14.16 9.97 31 440659 11354 70476400
Hypocalcaemia 14.07 9.97 195 440495 44664 70443090
Unevaluable event 14.04 9.97 233 440457 51830 70435924
Eosinophil count increased 14.03 9.97 48 440642 15174 70472580
Antibody test positive 14.02 9.97 41 440649 2490 70485264
Osteopenia 13.95 9.97 162 440528 16535 70471219
Abortion threatened 13.90 9.97 15 440675 403 70487351
Gestational hypertension 13.89 9.97 33 440657 1767 70485987
Respiratory tract infection viral 13.88 9.97 51 440639 3490 70484264
Memory impairment 13.87 9.97 454 440236 92187 70395567
Obstructive airways disorder 13.86 9.97 100 440590 26013 70461741
Human anti-human antibody test 13.84 9.97 15 440675 405 70487349
Breast cancer stage II 13.83 9.97 8 440682 5338 70482416
Joint warmth 13.83 9.97 30 440660 1512 70486242
Kidney infection 13.77 9.97 183 440507 19272 70468482
Complication of device insertion 13.76 9.97 8 440682 5324 70482430
Hydrocephalus 13.76 9.97 18 440672 8067 70479687
Arthritis bacterial 13.75 9.97 93 440597 8140 70479614
Left ventricular dysfunction 13.74 9.97 61 440629 17896 70469858
Anal fistula 13.71 9.97 74 440616 5976 70481778
Drug tolerance 13.68 9.97 86 440604 7342 70480412
Pneumonia bacterial 13.68 9.97 55 440635 16586 70471168
Pancreatic steatosis 13.62 9.97 24 440666 1036 70486718
Haematemesis 13.62 9.97 217 440473 48580 70439174
Transaminases increased 13.49 9.97 208 440482 46810 70440944
Hepatic cirrhosis 13.47 9.97 267 440423 30464 70457290
Hepatitis E antibody positive 13.37 9.97 12 440678 256 70487498
Iodine allergy 13.35 9.97 17 440673 547 70487207
Clear cell renal cell carcinoma 13.35 9.97 38 440652 2272 70485482
Haemodynamic instability 13.35 9.97 51 440639 15607 70472147
Kidney transplant rejection 13.34 9.97 26 440664 9935 70477819
Therapeutic product effect incomplete 13.33 9.97 890 439800 118992 70368762
Genital haemorrhage 13.29 9.97 10 440680 5805 70481949
Blood folate increased 13.28 9.97 16 440674 486 70487268
Renal tubular necrosis 13.15 9.97 87 440603 23084 70464670
Salivary hypersecretion 13.14 9.97 39 440651 12886 70474868
Diaphragmatic disorder 13.13 9.97 30 440660 1566 70486188
Accidental death 13.07 9.97 4 440686 3904 70483850
Drug specific antibody 13.06 9.97 38 440652 2301 70485453
Arthropod bite 13.05 9.97 84 440606 7231 70480523
Small for dates baby 13.02 9.97 15 440675 434 70487320
Breast abscess 13.01 9.97 26 440664 1236 70486518
Blood loss anaemia 12.99 9.97 46 440644 14395 70473359
Skin exfoliation 12.99 9.97 218 440472 48408 70439346
Dry skin 12.98 9.97 257 440433 55674 70432080
Injection site extravasation 12.97 9.97 96 440594 8650 70479104
Sinus congestion 12.96 9.97 165 440525 17208 70470546
Osteoporotic fracture 12.79 9.97 52 440638 3732 70484022
COVID-19 12.76 9.97 532 440158 105225 70382529
Ventricular arrhythmia 12.75 9.97 18 440672 7812 70479942
Maternal exposure during breast feeding 12.75 9.97 37 440653 2237 70485517
Oesophageal fibrosis 12.74 9.97 10 440680 176 70487578
Device related infection 12.74 9.97 133 440557 32052 70455702
Hypoxic-ischaemic encephalopathy 12.72 9.97 16 440674 7292 70480462
Dementia 12.68 9.97 84 440606 22281 70465473
Delivery 12.68 9.97 17 440673 576 70487178
Umbilical hernia 12.65 9.97 65 440625 5151 70482603
Type 1 diabetes mellitus 12.59 9.97 12 440678 6202 70481552
Blood glucose decreased 12.59 9.97 93 440597 24066 70463688
Cholestasis of pregnancy 12.53 9.97 22 440668 947 70486807
Uterine perforation 12.38 9.97 11 440679 5880 70481874
Epilepsy 12.38 9.97 168 440522 38616 70449138
Hyperlipidaemia 12.37 9.97 92 440598 23771 70463983
Hepatic cancer 12.35 9.97 26 440664 9657 70478097
Electrolyte imbalance 12.33 9.97 107 440583 26754 70461000
Pharyngitis 12.23 9.97 186 440504 20165 70467589
Hypophagia 12.23 9.97 183 440507 41387 70446367
C-reactive protein decreased 12.23 9.97 38 440652 2386 70485368
Cellulitis 12.20 9.97 741 439949 98187 70389567
Insomnia 12.19 9.97 1176 439514 216630 70271124
Motor dysfunction 12.19 9.97 41 440649 13029 70474725
Mycobacterium tuberculosis complex test positive 12.17 9.97 37 440653 2296 70485458
Nail injury 12.16 9.97 16 440674 532 70487222
Tendon disorder 12.16 9.97 76 440614 6475 70481279
Metastasis 12.16 9.97 12 440678 6102 70481652
Stress at work 12.15 9.97 23 440667 1050 70486704
Lower respiratory tract congestion 12.14 9.97 47 440643 3297 70484457
Brain natriuretic peptide increased 12.14 9.97 20 440670 8151 70479603
Strongyloidiasis 12.11 9.97 4 440686 3719 70484035
Oesophageal carcinoma 12.07 9.97 25 440665 9341 70478413
Generalised tonic-clonic seizure 12.05 9.97 184 440506 41477 70446277
Personality change 12.01 9.97 23 440667 8847 70478907
Renal disorder 12.00 9.97 165 440525 37844 70449910
Alcohol interaction 11.98 9.97 7 440683 4646 70483108
Sensitivity to weather change 11.98 9.97 83 440607 7322 70480432
Hepatic cytolysis 11.96 9.97 70 440620 19122 70468632
Defaecation disorder 11.94 9.97 17 440673 610 70487144
Hypotonia 11.92 9.97 36 440654 11829 70475925
Musculoskeletal discomfort 11.91 9.97 166 440524 17666 70470088
Hernia 11.89 9.97 143 440547 14717 70473037
Multiple-drug resistance 11.89 9.97 17 440673 7338 70480416
Acute pulmonary oedema 11.88 9.97 43 440647 13369 70474385
Blood urea increased 11.88 9.97 207 440483 45702 70442052
Systemic inflammatory response syndrome 11.87 9.97 31 440659 10681 70477073
Labyrinthitis 11.85 9.97 41 440649 2723 70485031
Intestinal ischaemia 11.84 9.97 37 440653 12027 70475727
Photophobia 11.82 9.97 172 440518 18478 70469276
Epistaxis 11.81 9.97 519 440171 102108 70385646
Injection site discolouration 11.78 9.97 80 440610 7012 70480742
Parkinsonism 11.76 9.97 52 440638 15273 70472481
Hypertriglyceridaemia 11.75 9.97 36 440654 11775 70475979
Anti-neutrophil cytoplasmic antibody positive vasculitis 11.72 9.97 3 440687 3294 70484460
Tooth fracture 11.67 9.97 109 440581 10518 70477236
Skin ulcer haemorrhage 11.56 9.97 15 440675 492 70487262
Skin neoplasm excision 11.56 9.97 21 440669 929 70486825
Ketoacidosis 11.55 9.97 17 440673 7252 70480502
Breast cancer metastatic 11.52 9.97 29 440661 10117 70477637
Abortion missed 11.50 9.97 24 440666 1177 70486577
Product administered to patient of inappropriate age 11.49 9.97 8 440682 4835 70482919
Aplasia 11.48 9.97 17 440673 7234 70480520
Threatened labour 11.45 9.97 16 440674 564 70487190
Jaundice cholestatic 11.43 9.97 25 440665 9159 70478595
Ligament rupture 11.42 9.97 42 440648 2875 70484879
Complications of transplanted kidney 11.40 9.97 12 440678 5922 70481832
Coronary artery bypass 11.34 9.97 12 440678 5908 70481846
Myofascial pain syndrome 11.34 9.97 31 440659 1811 70485943
Product preparation error 11.28 9.97 7 440683 4495 70483259
Lymphopenia 11.26 9.97 112 440578 27247 70460507
Intervertebral disc degeneration 11.23 9.97 134 440556 13766 70473988
Atrial flutter 11.20 9.97 77 440613 20250 70467504
Swollen joint count 11.20 9.97 21 440669 952 70486802
Multiple drug therapy 11.17 9.97 3 440687 3189 70484565
Vacuum extractor delivery 11.10 9.97 8 440682 123 70487631
Immune thrombocytopenia 11.01 9.97 58 440632 16266 70471488
Haemodialysis 11.00 9.97 63 440627 17303 70470451
Renal cancer 11.00 9.97 37 440653 11759 70475995
Acute graft versus host disease in intestine 10.93 9.97 5 440685 3811 70483943
Cystitis 10.92 9.97 375 440315 46566 70441188
Postpartum haemorrhage 10.91 9.97 27 440663 1484 70486270
Ataxia 10.88 9.97 92 440598 23125 70464629
Skin graft failure 10.85 9.97 10 440680 221 70487533
Colitis microscopic 10.81 9.97 25 440665 8980 70478774
Chills 10.79 9.97 764 439926 144022 70343732
Capillary leak syndrome 10.78 9.97 4 440686 3458 70484296
Immune-mediated myositis 10.77 9.97 3 440687 3113 70484641
Catheter management 10.77 9.97 4 440686 3455 70484299
Anal fissure 10.77 9.97 71 440619 6162 70481592
Oxygen consumption increased 10.75 9.97 8 440682 4672 70483082
Lower limb fracture 10.75 9.97 155 440535 16617 70471137
Serum ferritin increased 10.72 9.97 94 440596 8911 70478843
Vascular device infection 10.72 9.97 21 440669 8009 70479745
Fungaemia 10.71 9.97 6 440684 4076 70483678
Catheter site erythema 10.69 9.97 9 440681 4939 70482815
Hospitalisation 10.68 9.97 412 440278 82156 70405598
Hepatitis E virus test positive 10.67 9.97 11 440679 280 70487474
Device dislocation 10.63 9.97 89 440601 22418 70465336
Liver injury 10.63 9.97 332 440358 40703 70447051
Hypoglycaemic coma 10.62 9.97 7 440683 4354 70483400
Pericardial effusion 10.61 9.97 189 440501 41587 70446167
Plasmacytoma 10.58 9.97 6 440684 4048 70483706
Bradykinesia 10.56 9.97 19 440671 7483 70480271
Mesothelioma 10.56 9.97 12 440678 342 70487412
Plasma cell myeloma recurrent 10.55 9.97 7 440683 4339 70483415
Increased tendency to bruise 10.51 9.97 99 440591 9576 70478178
Abortion incomplete 10.48 9.97 3 440687 3059 70484695
Benign ovarian tumour 10.45 9.97 11 440679 287 70487467
Lymphoedema 10.44 9.97 35 440655 11134 70476620
Palindromic rheumatism 10.44 9.97 13 440677 409 70487345
Investigation abnormal 10.41 9.97 30 440660 1807 70485947
Short stature 10.39 9.97 13 440677 411 70487343
Faecal calprotectin increased 10.38 9.97 55 440635 4410 70483344
Chondropathy 10.38 9.97 36 440654 2394 70485360
Congestive cardiomyopathy 10.38 9.97 34 440656 10892 70476862
Sleep disorder due to a general medical condition 10.37 9.97 32 440658 10444 70477310
Pancreatic duct stenosis 10.35 9.97 10 440680 235 70487519
Pleural fibrosis 10.33 9.97 52 440638 4087 70483667
Anal skin tags 10.29 9.97 13 440677 415 70487339
Depressed mood 10.27 9.97 201 440489 43619 70444135
Respiratory syncytial virus infection 10.24 9.97 20 440670 7635 70480119
Excessive cerumen production 10.23 9.97 16 440674 625 70487129
Bronchial secretion retention 10.21 9.97 3 440687 3007 70484747
Pseudomembranous colitis 10.20 9.97 10 440680 5101 70482653
Dermatitis allergic 10.20 9.97 151 440539 16280 70471474
Liver transplant 10.19 9.97 7 440683 4259 70483495
Nephrotic syndrome 10.18 9.97 33 440657 10607 70477147
Hyperpyrexia 10.18 9.97 11 440679 5363 70482391
Hepatitis B 10.17 9.97 22 440668 8092 70479662
Hyperhomocysteinaemia 10.17 9.97 13 440677 420 70487334
Bundle branch block left 10.13 9.97 32 440658 10367 70477387
Hypercapnia 10.10 9.97 23 440667 8306 70479448
Laryngospasm 10.09 9.97 5 440685 3638 70484116
Decreased insulin requirement 10.08 9.97 8 440682 143 70487611
Anticholinergic syndrome 10.06 9.97 3 440687 2977 70484777
Vascular insufficiency 10.05 9.97 14 440676 492 70487262
Vascular rupture 10.04 9.97 26 440664 1470 70486284
Dermatitis atopic 10.03 9.97 26 440664 8981 70478773
Nephrolithiasis 10.01 9.97 374 440316 46949 70440805
Embolism 10.01 9.97 44 440646 12944 70474810
Renal tubular disorder 10.00 9.97 14 440676 6096 70481658

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
ATC A11HA01 ALIMENTARY TRACT AND METABOLISM
VITAMINS
OTHER PLAIN VITAMIN PREPARATIONS
Other plain vitamin preparations
MeSH PA D018977 Micronutrients
MeSH PA D014803 Vitamin B Complex
MeSH PA D014815 Vitamins
CHEBI has role CHEBI:22586 antioxidants
CHEBI has role CHEBI:23357 cofactor
CHEBI has role CHEBI:25212 metabolites
CHEBI has role CHEBI:61115 histone deacetylase inhibitors
CHEBI has role CHEBI:62913 PARP
CHEBI has role CHEBI:63726 neuroprotective agents
CHEBI has role CHEBI:67079 anti-inflammatory agents
CHEBI has role CHEBI:71181 Sir2 inhibitors
CHEBI has role CHEBI:75771 Mus musculus metabolites
CHEBI has role CHEBI:75772 S. cerevisiae metabolites
CHEBI has role CHEBI:76971 Escherichia coli metabolites
CHEBI has role CHEBI:84087 human urinary metabolites
CHEBI has role CHEBI:176497 geroprotectors

Drug Use | Suggest Off label Use Form| |View source of the data|

DiseaseRelationSNOMED_IDDOID
Acne vulgaris indication 88616000
Pellagra indication 418186002 DOID:8457
Niacin deficiency indication 418279001
Methemoglobinemia off-label use 38959009 DOID:10783
Goiter contraindication 3716002 DOID:12176
Peptic ulcer contraindication 13200003 DOID:750
Hyperkalemia contraindication 14140009
Primary hyperoxaluria contraindication 17901006 DOID:2977
Hashimoto thyroiditis contraindication 21983002
Acute tuberculosis contraindication 25629007
Bronchitis contraindication 32398004 DOID:6132
Low blood pressure contraindication 45007003
Blood coagulation disorder contraindication 64779008 DOID:1247
Diabetes mellitus contraindication 73211009 DOID:9351
Gout contraindication 90560007 DOID:13189
Kidney disease contraindication 90708001 DOID:557
Hemophilia contraindication 90935002
Dermatitis herpetiformis contraindication 111196000 DOID:8505
Anemia due to enzyme deficiency contraindication 111577008
Hb SS disease contraindication 127040003 DOID:10923
Arterial hemorrhage contraindication 234003006
Disease of liver contraindication 235856003 DOID:409
Hypocomplementemic urticarial vasculitis contraindication 239945009
Rhabdomyolysis contraindication 240131006
Pregnancy, function contraindication 289908002
Acute coronary syndrome contraindication 394659003
Hemochromatosis contraindication 399187006 DOID:2352




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 11.95 acidic
pKa2 3.41 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])		Mechanism
action		Bioact sourceMoA source
Hydroxycarboxylic acid receptor 2 GPCR WOMBAT-PK
Hydroxycarboxylic acid receptor 3 GPCR WOMBAT-PK
Nicotinamide N-methyltransferase Enzyme WOMBAT-PK
Nicotinate-nucleotide pyrophosphorylase [carboxylating] Enzyme WOMBAT-PK
NAD-dependent protein deacetylase sirtuin-1 Enzyme IC50 4.30 CHEMBL
NAD-dependent protein deacetylase sirtuin-2 Enzyme IC50 5.92 CHEMBL
NAD-dependent deacetylase sirtuin 3 Enzyme IC50 4.85 CHEMBL
NAD-dependent protein deacylase sirtuin-5, mitochondrial Enzyme IC50 4.33 CHEMBL
Sterile alpha and TIR motif-containing protein 1 Unclassified IC50 4.36 CHEMBL
Fatty-acid amide hydrolase 1 Enzyme IC50 5.48 CHEMBL
NAD-dependent deacetylase HST2 Enzyme IC50 4.04 CHEMBL
Putative silent information regulator 2 Unclassified IC50 4.40 CHEMBL
NAD-dependent protein deacetylase Unclassified IC50 4.64 CHEMBL

External reference:

IDSource
4020285 VUID
N0000148162 NUI
D00036 KEGG_DRUG
4017632 VANDF
4017718 VANDF
4020285 VANDF
C0028027 UMLSCUI
CHEBI:17154 CHEBI
NCA PDB_CHEM_ID
CHEMBL1140 ChEMBL_ID
936 PUBCHEM_CID
DB02701 DRUGBANK_ID
25X51I8RD4 UNII
7405 RXNORM
4947 MMSL
5170 MMSL
5684 MMSL
72420 MMSL
d03739 MMSL
001055 NDDF
173196005 SNOMEDCT_US
D009536 MESH_DESCRIPTOR_UI
404 INN_ID

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
NataFort HUMAN PRESCRIPTION DRUG LABEL 10 0178-0716 TABLET 20 mg ORAL Unapproved drug other 12 sections
CitraNatal 90 DHA HUMAN PRESCRIPTION DRUG LABEL 16 0178-0821 TABLET 20 mg ORAL unapproved drug other 11 sections
CitraNatal 90 DHA HUMAN PRESCRIPTION DRUG LABEL 16 0178-0821 TABLET 20 mg ORAL unapproved drug other 11 sections
CitraNatal 90 DHA HUMAN OTC DRUG LABEL 14 0178-0829 TABLET 20 mg ORAL Unapproved drug other 11 sections
CitraNatal Rx HUMAN PRESCRIPTION DRUG LABEL 13 0178-0858 TABLET 20 mg ORAL Unapproved drug other 12 sections
CitraNatal Rx HUMAN PRESCRIPTION DRUG LABEL 14 0178-0859 TABLET 20 mg ORAL Unapproved drug other 9 sections
CitraNatal DHA HUMAN OTC DRUG LABEL 14 0178-0898 TABLET 20 mg ORAL Unapproved drug other 11 sections
Vitafol Ultra HUMAN PRESCRIPTION DRUG LABEL 17 0642-0093 CAPSULE, LIQUID FILLED 15 mg ORAL UNAPPROVED DRUG OTHER 13 sections
Select OB HUMAN PRESCRIPTION DRUG LABEL 15 0642-0120 TABLET, CHEWABLE 15 mg ORAL UNAPPROVED DRUG OTHER 13 sections
Strovite One Caplets HUMAN PRESCRIPTION DRUG LABEL 20 0642-0207 TABLET 25 mg ORAL UNAPPROVED DRUG OTHER 14 sections
Vitafol Fe Plus HUMAN PRESCRIPTION DRUG LABEL 17 0642-7473 CAPSULE, LIQUID FILLED 15 mg ORAL UNAPPROVED DRUG OTHER 14 sections
Marnatal F HUMAN PRESCRIPTION DRUG LABEL 13 0682-1570 CAPSULE 20 mg ORAL UNAPPROVED DRUG OTHER 4 sections
BACMIN HUMAN PRESCRIPTION DRUG LABEL 19 0682-3001 TABLET, COATED 100 mg ORAL UNAPPROVED DRUG OTHER 10 sections
Dialyvite Supreme D HUMAN PRESCRIPTION DRUG LABEL 13 10542-009 TABLET, COATED 20 mg ORAL Unapproved drug other 7 sections
Dialyvite Supreme D HUMAN PRESCRIPTION DRUG LABEL 13 10542-009 TABLET, COATED 20 mg ORAL Unapproved drug other 7 sections
Dialyvite HUMAN PRESCRIPTION DRUG LABEL 9 10542-010 TABLET, COATED 20 mg ORAL Unapproved drug other 7 sections
Dialyvite HUMAN PRESCRIPTION DRUG LABEL 9 10542-010 TABLET, COATED 20 mg ORAL Unapproved drug other 7 sections
Dialyvite 5000 HUMAN PRESCRIPTION DRUG LABEL 12 10542-011 TABLET, COATED 20 mg ORAL Unapproved drug other 7 sections
Dialyvite 5000 HUMAN PRESCRIPTION DRUG LABEL 12 10542-011 TABLET, COATED 20 mg ORAL Unapproved drug other 7 sections
Dialyvite with Zinc HUMAN PRESCRIPTION DRUG LABEL 10 10542-012 TABLET, COATED 20 mg ORAL Unapproved drug other 7 sections
Dialyvite with Zinc HUMAN PRESCRIPTION DRUG LABEL 10 10542-012 TABLET, COATED 20 mg ORAL Unapproved drug other 7 sections
Dialyvite 3000 HUMAN PRESCRIPTION DRUG LABEL 12 10542-014 TABLET, COATED 20 mg ORAL Unapproved drug other 7 sections
Dialyvite 3000 HUMAN PRESCRIPTION DRUG LABEL 12 10542-014 TABLET, COATED 20 mg ORAL Unapproved drug other 7 sections
PRENATAL PLUS HUMAN PRESCRIPTION DRUG LABEL 15 10544-549 TABLET, FILM COATED 20 mg ORAL unapproved drug other 8 sections
PRENATAL PLUS IRON HUMAN PRESCRIPTION DRUG LABEL 15 10544-609 TABLET, FILM COATED 20 mg ORAL UNAPPROVED DRUG OTHER 7 sections
Se-Natal 19 HUMAN PRESCRIPTION DRUG LABEL 15 13925-116 TABLET 15 mg ORAL unapproved drug other 15 sections
Se-Natal 19 HUMAN PRESCRIPTION DRUG LABEL 15 13925-116 TABLET 15 mg ORAL unapproved drug other 15 sections
Se-Natal 19 Chewable HUMAN PRESCRIPTION DRUG LABEL 14 13925-117 TABLET, CHEWABLE 15 mg ORAL unapproved drug other 16 sections
Se-Tan PLUS HUMAN PRESCRIPTION DRUG LABEL 13 13925-118 CAPSULE, GELATIN COATED 30 ug ORAL unapproved drug other 19 sections
Se-Tan PLUS HUMAN PRESCRIPTION DRUG LABEL 13 13925-118 CAPSULE, GELATIN COATED 30 ug ORAL unapproved drug other 19 sections