neltenexine 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | PK/Tox | Related Drugs | BioActivity |

Stem definitionDrug idCAS RN
mucolytic, bromhexine derivatives 1894 99453-84-6

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • neltenexine monohydrate
  • neltenexine hydrochloride
  • neltenexine HCl
  • alveoten
  • neltenexine
elastase inhibitor; may be useful for preventing pulmonary emphysema
  • Molecular weight: 488.24
  • Formula: C18H20Br2N2O2S
  • CLOGP: 2.22
  • LIPINSKI: 0
  • HAC: 4
  • HDO: 3
  • TPSA: 61.36
  • ALOGS: -5.63
  • ROTB: 5

Drug dosage:

None

ADMET properties:

None

Predicted pharmacokinetic/toxicological properties (PK-AZ):

PropertyDescriptionValueUnitConfidenceSimilarity
kinase-safety-class ACVR2B,AKT2,AKT3,AURKA,AXL,BRAF,BTK,CAMK2B,CAMK2D,CDK5,CDK9,DDR1,DYRK1B,EIF2AK3,EPHB4,ERBB2,FLT3,GRK2,ITK,JAK2,MAP3K21,MAP3K7,MAPK10,MAPK12,MAPK7,MAPK9,MAPKAPK2,MARK4,MET,MTOR,NTRK2,PAK4,PDK1,PDK2,PDK4,PDPK1,PIK3CB,PIM2,PRKCD,PRKDC,SIK2,SIK3,STK33,SYK,TEK,TTK 46
kinase-selectivity-class AXL,DYRK1B,EIF2AK3,GRK2,IRAK1,SIK2,STK33,TTK 8
pfas-class PFAS structural alert (1 = True, 0 = False) 0

Approvals:

DateAgencyCompanyOrphan
Oct. 16, 2001 Korean Food and Drug Administration (KFDA)

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

None

FDA Adverse Event Reporting System (Geriatric)

None

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
ATC R05CB14 RESPIRATORY SYSTEM
COUGH AND COLD PREPARATIONS
EXPECTORANTS, EXCL. COMBINATIONS WITH COUGH SUPPRESSANTS
Mucolytics

Related Drugs by ATC class:

R05CB Mucolytics 13 drugs
acetylcysteineambroxolbromhexinecarbocisteinedomiodoldornase alfaeprazinoneerdosteineletosteinemannitolmesnasobrerol show all 13 →

Drug Use | Suggest Off label Use Form| |View source of the data|

DiseaseRelationSNOMED_IDDOID
Chronic bronchitis indication 63480004 DOID:6132




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 10.13 acidic
pKa2 7.27 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

None

External reference:

IDSource
D07382 KEGG_DRUG
99461-80-0 SECONDARY_CAS_RN
C0382131 UMLSCUI
CHEBI:135789 CHEBI
CHEMBL2106972 ChEMBL_ID
DB13239 DRUGBANK_ID
C095919 MESH_SUPPLEMENTAL_RECORD_UI
6529 INN_ID
U942DGM90X UNII
3047787 PUBCHEM_CID

Pharmaceutical products:

None