Stem definition | Drug id | CAS RN |
---|---|---|
1711 | 3375-50-6 |
Dose | Unit | Route |
---|---|---|
1.20 | g | Inhal.solution |
Property | Value | Reference |
---|---|---|
BDDCS (Biopharmaceutical Drug Disposition Classification System) | 1 | Benet LZ, Broccatelli F, Oprea TI |
MRTD (Maximum Recommended Therapeutic Daily Dose) | 28.13 µM/kg/day | Contrera JF, Matthews EJ, Kruhlak NL, Benz RD |
BA (Bioavailability) | 62 % | Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H |
Vd (Volume of distribution) | 0.65 L/kg | Lombardo F, Berellini G, Obach RS |
CL (Clearance) | 20.50 mL/min/kg | Lombardo F, Berellini G, Obach RS |
t_half (Half-life) | 0.36 hours | Lombardo F, Berellini G, Obach RS |
Date | Agency | Company | Orphan |
---|---|---|---|
Dec. 30, 1988 | FDA | BAXTER HLTHCARE |
MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
---|---|---|---|---|---|---|
Encephalopathy | 395.73 | 24.04 | 161 | 7198 | 33428 | 46645275 |
Febrile neutropenia | 362.91 | 24.04 | 210 | 7149 | 94417 | 46584286 |
Mucosal inflammation | 217.14 | 24.04 | 111 | 7248 | 38865 | 46639838 |
Pancytopenia | 133.45 | 24.04 | 109 | 7250 | 84949 | 46593754 |
Neutropenia | 131.70 | 24.04 | 136 | 7223 | 143068 | 46535635 |
Cystitis haemorrhagic | 106.30 | 24.04 | 34 | 7325 | 3513 | 46675190 |
Pyrexia | 101.84 | 24.04 | 190 | 7169 | 348612 | 46330091 |
Febrile bone marrow aplasia | 80.95 | 24.04 | 33 | 7326 | 6829 | 46671874 |
Neurotoxicity | 78.97 | 24.04 | 40 | 7319 | 13677 | 46665026 |
Toxic encephalopathy | 76.05 | 24.04 | 29 | 7330 | 5033 | 46673670 |
Cytomegalovirus infection | 71.13 | 24.04 | 41 | 7318 | 18103 | 46660600 |
Haematotoxicity | 67.22 | 24.04 | 29 | 7330 | 6904 | 46671799 |
Product use in unapproved indication | 60.83 | 24.04 | 73 | 7286 | 90200 | 46588503 |
Thrombocytopenia | 55.54 | 24.04 | 83 | 7276 | 126498 | 46552205 |
Leukopenia | 52.26 | 24.04 | 59 | 7300 | 68284 | 46610419 |
Drug ineffective | 47.48 | 24.04 | 24 | 7335 | 677814 | 46000889 |
Idiopathic pneumonia syndrome | 41.46 | 24.04 | 10 | 7349 | 362 | 46678341 |
Off label use | 40.97 | 24.04 | 142 | 7217 | 379699 | 46299004 |
Venoocclusive liver disease | 38.66 | 24.04 | 17 | 7342 | 4234 | 46674469 |
Vena cava thrombosis | 34.59 | 24.04 | 13 | 7346 | 2166 | 46676537 |
Bone marrow failure | 34.27 | 24.04 | 32 | 7327 | 29637 | 46649066 |
BK polyomavirus test positive | 34.19 | 24.04 | 6 | 7353 | 41 | 46678662 |
Hypokalaemia | 33.37 | 24.04 | 54 | 7305 | 87970 | 46590733 |
Cytokine release syndrome | 32.49 | 24.04 | 17 | 7342 | 6206 | 46672497 |
Sepsis | 32.08 | 24.04 | 68 | 7291 | 135946 | 46542757 |
Cardiotoxicity | 31.26 | 24.04 | 17 | 7342 | 6705 | 46671998 |
Mitral valve disease | 30.82 | 24.04 | 12 | 7347 | 2200 | 46676503 |
Anaemia | 30.49 | 24.04 | 99 | 7260 | 255680 | 46423023 |
Pneumothorax | 29.96 | 24.04 | 22 | 7337 | 14607 | 46664096 |
Chronic hepatitis B | 29.16 | 24.04 | 7 | 7352 | 248 | 46678455 |
Periorbital cellulitis | 29.04 | 24.04 | 8 | 7351 | 492 | 46678211 |
Arthralgia | 28.43 | 24.04 | 11 | 7348 | 364592 | 46314111 |
Blood phosphorus decreased | 27.36 | 24.04 | 13 | 7346 | 3867 | 46674836 |
Polyneuropathy | 27.26 | 24.04 | 19 | 7340 | 11625 | 46667078 |
Multiple organ dysfunction syndrome | 25.68 | 24.04 | 36 | 7323 | 51674 | 46627029 |
Hepatitis E | 25.68 | 24.04 | 9 | 7350 | 1230 | 46677473 |
Candida sepsis | 24.99 | 24.04 | 9 | 7350 | 1330 | 46677373 |
Hyperuricaemia | 24.95 | 24.04 | 13 | 7346 | 4704 | 46673999 |
Posterior reversible encephalopathy syndrome | 24.93 | 24.04 | 20 | 7339 | 15121 | 46663582 |
MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
---|---|---|---|---|---|---|
Febrile neutropenia | 416.05 | 21.10 | 291 | 7768 | 106402 | 29838017 |
Encephalopathy | 264.88 | 21.10 | 142 | 7917 | 32063 | 29912356 |
Cystitis haemorrhagic | 138.06 | 21.10 | 51 | 8008 | 4736 | 29939683 |
Venoocclusive liver disease | 115.38 | 21.10 | 49 | 8010 | 6564 | 29937855 |
Pyrexia | 91.47 | 21.10 | 226 | 7833 | 294263 | 29650156 |
Pancytopenia | 84.49 | 21.10 | 109 | 7950 | 84943 | 29859476 |
Neutropenia | 84.07 | 21.10 | 135 | 7924 | 128405 | 29816014 |
Febrile bone marrow aplasia | 81.60 | 21.10 | 41 | 8018 | 8056 | 29936363 |
Mucosal inflammation | 73.81 | 21.10 | 63 | 7996 | 30431 | 29913988 |
Cytokine release syndrome | 65.62 | 21.10 | 38 | 8021 | 9895 | 29934524 |
Haematotoxicity | 61.45 | 21.10 | 31 | 8028 | 6139 | 29938280 |
Aplasia | 60.88 | 21.10 | 27 | 8032 | 4010 | 29940409 |
Leukopenia | 60.49 | 21.10 | 75 | 7984 | 56084 | 29888335 |
Thrombocytopenia | 60.10 | 21.10 | 121 | 7938 | 136923 | 29807496 |
Fanconi syndrome | 58.96 | 21.10 | 21 | 8038 | 1754 | 29942665 |
Venoocclusive disease | 58.15 | 21.10 | 23 | 8036 | 2567 | 29941852 |
Neutrophil count decreased | 46.18 | 21.10 | 57 | 8002 | 42397 | 29902022 |
Acute graft versus host disease | 45.68 | 21.10 | 25 | 8034 | 5839 | 29938580 |
Foetal growth restriction | 41.62 | 21.10 | 20 | 8039 | 3565 | 29940854 |
Neurotoxicity | 39.80 | 21.10 | 31 | 8028 | 13151 | 29931268 |
Angiodysplasia | 38.17 | 21.10 | 11 | 8048 | 463 | 29943956 |
Polyneuropathy | 33.96 | 21.10 | 27 | 8032 | 11796 | 29932623 |
Fusarium infection | 33.12 | 21.10 | 12 | 8047 | 1052 | 29943367 |
Fall | 32.65 | 21.10 | 5 | 8054 | 181867 | 29762552 |
Stomatitis | 31.16 | 21.10 | 44 | 8015 | 37235 | 29907184 |
Bone marrow failure | 30.79 | 21.10 | 39 | 8020 | 29746 | 29914673 |
Myelosuppression | 30.69 | 21.10 | 21 | 8038 | 7301 | 29937118 |
Drug ineffective | 30.66 | 21.10 | 28 | 8031 | 340359 | 29604060 |
Chronic graft versus host disease | 30.54 | 21.10 | 17 | 8042 | 4102 | 29940317 |
Acute graft versus host disease in skin | 29.08 | 21.10 | 17 | 8042 | 4499 | 29939920 |
Septic shock | 27.59 | 21.10 | 56 | 8003 | 63551 | 29880868 |
Death | 27.03 | 21.10 | 34 | 8025 | 357249 | 29587170 |
Staphylococcal bacteraemia | 25.08 | 21.10 | 18 | 8041 | 6750 | 29937669 |
Non-Hodgkin's lymphoma unspecified histology aggressive | 24.71 | 21.10 | 5 | 8054 | 44 | 29944375 |
Drug therapeutic incompatibility | 24.59 | 21.10 | 6 | 8053 | 131 | 29944288 |
Cytomegalovirus hepatitis | 24.07 | 21.10 | 7 | 8052 | 304 | 29944115 |
Off label use | 24.02 | 21.10 | 131 | 7928 | 249159 | 29695260 |
Anaemia | 24.01 | 21.10 | 115 | 7944 | 207877 | 29736542 |
Myocardial infarction | 23.59 | 21.10 | 3 | 8056 | 125622 | 29818797 |
Osmotic demyelination syndrome | 22.34 | 21.10 | 8 | 8051 | 678 | 29943741 |
Pulpitis dental | 22.23 | 21.10 | 7 | 8052 | 399 | 29944020 |
Low birth weight baby | 22.15 | 21.10 | 16 | 8043 | 6060 | 29938359 |
Chloroma | 21.59 | 21.10 | 7 | 8052 | 439 | 29943980 |
Agranulocytosis | 21.52 | 21.10 | 28 | 8031 | 21914 | 29922505 |
Pulmonary toxicity | 21.45 | 21.10 | 14 | 8045 | 4502 | 29939917 |
Toxic encephalopathy | 21.18 | 21.10 | 14 | 8045 | 4595 | 29939824 |
Source | Code | Description |
---|---|---|
ATC | R05CB05 | RESPIRATORY SYSTEM COUGH AND COLD PREPARATIONS EXPECTORANTS, EXCL. COMBINATIONS WITH COUGH SUPPRESSANTS Mucolytics |
ATC | V03AF01 | VARIOUS ALL OTHER THERAPEUTIC PRODUCTS ALL OTHER THERAPEUTIC PRODUCTS Detoxifying agents for antineoplastic treatment |
MeSH PA | D020011 | Protective Agents |
CHEBI has role | CHEBI:23354 | coenzymes |
Disease | Relation | SNOMED_ID | DOID |
---|---|---|---|
Testicular Germ Cell Tumor | indication | ||
Prevention of Chemotherapy-Induced Hemorrhagic Cystitis | indication | ||
Ewing's sarcoma | off-label use | 76909002 | DOID:3369 |
Burkitt's lymphoma | off-label use | 118617000 | |
Non-small cell lung cancer | off-label use | 254637007 | DOID:3908 |
Malignant tumor of head and/or neck | off-label use | 255056009 | |
Osteosarcoma of bone | off-label use | 307576001 | DOID:3376 |
Soft or Connective Tissue Sarcoma | off-label use | ||
Renal tubular acidosis | contraindication | 1776003 | DOID:14219 |
Hyperbilirubinemia | contraindication | 14783006 | DOID:2741 |
Dehydration | contraindication | 34095006 | |
Fanconi syndrome | contraindication | 40488004 | DOID:1062 |
Hypokalemia | contraindication | 43339004 | |
Leukopenia | contraindication | 84828003 | DOID:615 |
Kidney disease | contraindication | 90708001 | DOID:557 |
Kidney excision | contraindication | 108022006 | |
Liver function tests abnormal | contraindication | 166603001 | |
Disease of liver | contraindication | 235856003 | DOID:409 |
Impaired wound healing | contraindication | 271618001 | |
Anemia | contraindication | 271737000 | DOID:2355 |
Pregnancy, function | contraindication | 289908002 | |
Thrombocytopenic disorder | contraindication | 302215000 | DOID:1588 |
Bone marrow depression | contraindication | 307762000 | |
Coma | contraindication | 371632003 | |
Impaired cognition | contraindication | 386806002 | |
Breastfeeding (mother) | contraindication | 413712001 | |
Cancer Chemotherapy Induced Hemorrhagic Cystitis | contraindication | ||
Polyneuropathies | contraindication | ||
Severe Bone Marrow Depression | contraindication | ||
Bone Metastases | contraindication | ||
CNS Toxicity | contraindication |
Dissociation level | Dissociation constant | Type (acidic/basic) |
---|---|---|
pKa1 | 0.61 | acidic |
pKa2 | 9.77 | acidic |
None
None
None
ID | Source |
---|---|
4019477 | VUID |
N0000147597 | NUI |
D01459 | KEGG_DRUG |
19767-45-4 | SECONDARY_CAS_RN |
4019477 | VANDF |
C0000294 | UMLSCUI |
CHEBI:17905 | CHEBI |
COM | PDB_CHEM_ID |
CHEMBL975 | ChEMBL_ID |
CHEMBL1098319 | ChEMBL_ID |
D015080 | MESH_DESCRIPTOR_UI |
DB09110 | DRUGBANK_ID |
2813 | INN_ID |
NR7O1405Q9 | UNII |
23662354 | PUBCHEM_CID |
1546354 | RXNORM |
41498 | MMSL |
5057 | MMSL |
d01411 | MMSL |
002678 | NDDF |
108821000 | SNOMEDCT_US |
386922000 | SNOMEDCT_US |
Product | Category | Ingredients | NDC | Form | Quantity | Route | Marketing | Label |
---|---|---|---|---|---|---|---|---|
MESNEX | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0338-1305 | INJECTION, SOLUTION | 100 mg | INTRAVENOUS | NDA | 27 sections |
MESNULL | HUMAN PRESCRIPTION DRUG LABEL | 1 | 10019-951 | INJECTION, SOLUTION | 100 mg | INTRAVENOUS | NDA | 26 sections |
MESNULL | HUMAN PRESCRIPTION DRUG LABEL | 1 | 10019-953 | INJECTION, SOLUTION | 100 mg | INTRAVENOUS | NDA | 26 sections |
Mesna | HUMAN PRESCRIPTION DRUG LABEL | 1 | 25021-201 | INJECTION, SOLUTION | 100 mg | INTRAVENOUS | ANDA | 26 sections |
Mesna | HUMAN PRESCRIPTION DRUG LABEL | 1 | 25021-201 | INJECTION, SOLUTION | 100 mg | INTRAVENOUS | ANDA | 26 sections |
Mesna | Human Prescription Drug Label | 1 | 63323-733 | INJECTION, SOLUTION | 100 mg | INTRAVENOUS | ANDA | 27 sections |
MESNEX | HUMAN PRESCRIPTION DRUG LABEL | 1 | 67108-3565 | TABLET, FILM COATED | 400 mg | ORAL | NDA | 26 sections |
Mesna | Human Prescription Drug Label | 1 | 68083-161 | SOLUTION | 100 mg | INTRAVENOUS | ANDA | 26 sections |
Mesna | HUMAN PRESCRIPTION DRUG LABEL | 1 | 70860-209 | INJECTION, SOLUTION | 100 mg | INTRAVENOUS | ANDA | 27 sections |