bromhexine Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
mucolytic, bromhexine derivatives 402 3572-43-8

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • bromhexine
  • bromexine
  • bromhexine hydrochloride
  • bromhexine HCl
  • bromhexine monohydrochloride
A mucolytic agent used in the treatment of respiratory disorders associated with viscid or excessive mucus. (From Martindale, The Extra Pharmacopoeia, 30th ed, p744)
  • Molecular weight: 376.14
  • Formula: C14H20Br2N2
  • CLOGP: 4.88
  • LIPINSKI: 0
  • HAC: 2
  • HDO: 1
  • TPSA: 29.26
  • ALOGS: -5.02
  • ROTB: 3

Drug dosage:

DoseUnitRoute
24 mg O
24 mg P

ADMET properties:

PropertyValueReference
BA (Bioavailability) 77.50 % Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H

Approvals:

None

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Pneumonia aspiration 44.44 30.15 18 846 31587 46653611
Pneumonia 35.76 30.15 39 825 376281 46308917

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Pneumonia 35.58 31.91 44 763 334262 29617409

Pharmacologic Action:

SourceCodeDescription
ATC R05CB02 RESPIRATORY SYSTEM
COUGH AND COLD PREPARATIONS
EXPECTORANTS, EXCL. COMBINATIONS WITH COUGH SUPPRESSANTS
Mucolytics
MeSH PA D005100 Expectorants
MeSH PA D019141 Respiratory System Agents
CHEBI has role CHEBI:77034 mucolytics

Drug Use (View source of the data)

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 8.16 Basic
pKa2 0.87 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
Sigma non-opioid intracellular receptor 1 Membrane receptor Ki 7.60 DRUG MATRIX
Sodium-dependent serotonin transporter Transporter Ki 5.95 DRUG MATRIX
Cytochrome P450 2D6 Enzyme IC50 6.71 DRUG MATRIX
Membrane-associated progesterone receptor component 1 Membrane receptor Ki 7.44 DRUG MATRIX

External reference:

IDSource
Q1J152VB1P UNII
N0000166541 NUI
D01778 KEGG_DRUG
611-75-6 SECONDARY_CAS_RN
C0006220 UMLSCUI
CHEBI:77032 CHEBI
CHEMBL253376 ChEMBL_ID
CHEMBL1319139 ChEMBL_ID
DB09019 DRUGBANK_ID
D001964 MESH_DESCRIPTOR_UI
2584 INN_ID
2442 PUBCHEM_CID
11218 IUPHAR_LIGAND_ID
1601 RXNORM
NOCODE MMSL
003678 NDDF
003679 NDDF
412102008 SNOMEDCT_US
708561003 SNOMEDCT_US
846647005 SNOMEDCT_US

Pharmaceutical products:

None