All FDA-approved EMA-approved PMDA-approved
Target Card Uniprot Example: P23975

bromhexine 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definition	Drug id	CAS RN
mucolytic, bromhexine derivatives	402	3572-43-8

Description:

Molecule	Description
Molfile Inchi Smiles Synonyms: bromhexine bromexine bromhexine hydrochloride bromhexine HCl bromhexine monohydrochloride	A mucolytic agent used in the treatment of respiratory disorders associated with viscid or excessive mucus. (From Martindale, The Extra Pharmacopoeia, 30th ed, p744) Molecular weight: 376.14 Formula: C14H20Br2N2 CLOGP: 4.88 LIPINSKI: 0 HAC: 2 HDO: 1 TPSA: 29.26 ALOGS: -5.02 ROTB: 3

Drug dosage:

Dose	Unit	Route
24	mg	O
24	mg	P

ADMET properties:

Property	Value	Reference
BA (Bioavailability)	77.50 %	Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H

Approvals:

None

FDA Adverse Event Reporting System (Female)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Pneumonia aspiration	75.89	26.98	26	847	30978	50573273
Gastrooesophageal reflux disease	41.49	26.98	22	851	76406	50527845
Coma	41.48	26.98	20	853	56859	50547392
Underdose	30.85	26.98	12	861	20266	50583985
Somnolence	29.41	26.98	23	850	154962	50449289

FDA Adverse Event Reporting System (Male)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Pneumonia	35.95	31.18	43	743	320129	29253612

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Pneumonia aspiration	79.65	23.41	37	1780	59234	64437681
Pneumonia	50.94	23.41	70	1747	559506	63937409
Gastrooesophageal reflux disease	32.00	23.41	23	1794	83120	64413795
Coma	28.70	23.41	22	1795	87593	64409322
Upper respiratory tract inflammation	26.67	23.41	8	1809	3774	64493141

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

Source	Code	Description
ATC	R05CB02	RESPIRATORY SYSTEM COUGH AND COLD PREPARATIONS EXPECTORANTS, EXCL. COMBINATIONS WITH COUGH SUPPRESSANTS Mucolytics
MeSH PA	D005100	Expectorants
MeSH PA	D019141	Respiratory System Agents
CHEBI has role	CHEBI:77034	mucolytics

Drug Use | Suggest Off label Use Form| |View source of the data|

None

🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation level	Dissociation constant	Type (acidic/basic)
pKa1	8.16	Basic
pKa2	0.87	Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

Target	Class	Pharos	UniProt	Action	Type	Activity value (-log[M])	Mechanism action	Bioact source	MoA source
Sigma non-opioid intracellular receptor 1	Membrane receptor	Q99720	SGMR1_HUMAN		Ki	7.60		DRUG MATRIX
Sodium-dependent serotonin transporter	Transporter	P31645	SC6A4_HUMAN		Ki	5.95		DRUG MATRIX
Cytochrome P450 2D6	Enzyme	P10635	CP2D6_HUMAN		IC50	6.71		DRUG MATRIX
Membrane-associated progesterone receptor component 1	Membrane receptor		PGRC1_RAT		Ki	7.44		DRUG MATRIX

External reference:

ID	Source
N0000166541	NUI
D01778	KEGG_DRUG
1601	RXNORM
C0006220	UMLSCUI
CHEBI:77032	CHEBI
CHEMBL253376	ChEMBL_ID
DB09019	DRUGBANK_ID
D001964	MESH_DESCRIPTOR_UI
2442	PUBCHEM_CID
11218	IUPHAR_LIGAND_ID
2584	INN_ID
611-75-6	SECONDARY_CAS_RN
Q1J152VB1P	UNII
NOCODE	MMSL
003678	NDDF
003679	NDDF
412102008	SNOMEDCT_US
708561003	SNOMEDCT_US
846647005	SNOMEDCT_US
CHEMBL1319139	ChEMBL_ID

Pharmaceutical products:

None