Stem definition | Drug id | CAS RN |
---|---|---|
mucolytic, bromhexine derivatives | 402 | 3572-43-8 |
Dose | Unit | Route |
---|---|---|
24 | mg | O |
24 | mg | P |
Property | Value | Reference |
---|---|---|
BA (Bioavailability) | 77.50 % | Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H |
None
MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
---|---|---|---|---|---|---|
Pneumonia aspiration | 44.44 | 30.15 | 18 | 846 | 31587 | 46653611 |
Pneumonia | 35.76 | 30.15 | 39 | 825 | 376281 | 46308917 |
MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
---|---|---|---|---|---|---|
Pneumonia | 35.58 | 31.91 | 44 | 763 | 334262 | 29617409 |
Source | Code | Description |
---|---|---|
ATC | R05CB02 | RESPIRATORY SYSTEM COUGH AND COLD PREPARATIONS EXPECTORANTS, EXCL. COMBINATIONS WITH COUGH SUPPRESSANTS Mucolytics |
MeSH PA | D005100 | Expectorants |
MeSH PA | D019141 | Respiratory System Agents |
CHEBI has role | CHEBI:77034 | mucolytics |
None
Dissociation level | Dissociation constant | Type (acidic/basic) |
---|---|---|
pKa1 | 8.16 | Basic |
pKa2 | 0.87 | Basic |
None
None
Target | Class | Pharos | UniProt | Action | Type | Activity value (-log[M]) | Mechanism action | Bioact source | MoA source |
---|---|---|---|---|---|---|---|---|---|
Sigma non-opioid intracellular receptor 1 | Membrane receptor | Ki | 7.60 | DRUG MATRIX | |||||
Sodium-dependent serotonin transporter | Transporter | Ki | 5.95 | DRUG MATRIX | |||||
Cytochrome P450 2D6 | Enzyme | IC50 | 6.71 | DRUG MATRIX | |||||
Membrane-associated progesterone receptor component 1 | Membrane receptor | Ki | 7.44 | DRUG MATRIX |
ID | Source |
---|---|
Q1J152VB1P | UNII |
N0000166541 | NUI |
D01778 | KEGG_DRUG |
611-75-6 | SECONDARY_CAS_RN |
C0006220 | UMLSCUI |
CHEBI:77032 | CHEBI |
CHEMBL253376 | ChEMBL_ID |
CHEMBL1319139 | ChEMBL_ID |
DB09019 | DRUGBANK_ID |
D001964 | MESH_DESCRIPTOR_UI |
2584 | INN_ID |
2442 | PUBCHEM_CID |
11218 | IUPHAR_LIGAND_ID |
1601 | RXNORM |
NOCODE | MMSL |
003678 | NDDF |
003679 | NDDF |
412102008 | SNOMEDCT_US |
708561003 | SNOMEDCT_US |
846647005 | SNOMEDCT_US |
None