bromhexine Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |
| Stem definition | Drug id | CAS RN |
|---|---|---|
| mucolytic, bromhexine derivatives | 402 | 3572-43-8 |
Description:
| Molecule | Description |
|---|---|
|
Synonyms:
|
A mucolytic agent used in the treatment of respiratory disorders associated with viscid or excessive mucus. (From Martindale, The Extra Pharmacopoeia, 30th ed, p744)
|
Drug dosage:
| Dose | Unit | Route |
|---|---|---|
| 24 | mg | O |
| 24 | mg | P |
ADMET properties:
| Property | Value | Reference |
|---|---|---|
| BA (Bioavailability) | 77.50 % | Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H |
Approvals:
None
FDA Adverse Event Reporting System (Female)
| MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
|---|---|---|---|---|---|---|
| Pneumonia aspiration | 44.44 | 30.15 | 18 | 846 | 31587 | 46653611 |
| Pneumonia | 35.76 | 30.15 | 39 | 825 | 376281 | 46308917 |
FDA Adverse Event Reporting System (Male)
| MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
|---|---|---|---|---|---|---|
| Pneumonia | 35.58 | 31.91 | 44 | 763 | 334262 | 29617409 |
Pharmacologic Action:
| Source | Code | Description |
|---|---|---|
| ATC | R05CB02 | RESPIRATORY SYSTEM COUGH AND COLD PREPARATIONS EXPECTORANTS, EXCL. COMBINATIONS WITH COUGH SUPPRESSANTS Mucolytics |
| MeSH PA | D005100 | Expectorants |
| MeSH PA | D019141 | Respiratory System Agents |
| CHEBI has role | CHEBI:77034 | mucolytics |
Drug Use (View source of the data)
None
Acid dissociation constants calculated using MoKa v3.0.0
| Dissociation level | Dissociation constant | Type (acidic/basic) |
|---|---|---|
| pKa1 | 8.16 | Basic |
| pKa2 | 0.87 | Basic |
Orange Book patent data (new drug applications)
None
Orange Book exclusivity data (new drug applications)
None
Bioactivity Summary:
| Target | Class | Pharos | UniProt | Action | Type | Activity value (-log[M]) | Mechanism action | Bioact source | MoA source |
|---|---|---|---|---|---|---|---|---|---|
| Sigma non-opioid intracellular receptor 1 | Membrane receptor | Ki | 7.60 | DRUG MATRIX | |||||
| Sodium-dependent serotonin transporter | Transporter | Ki | 5.95 | DRUG MATRIX | |||||
| Cytochrome P450 2D6 | Enzyme | IC50 | 6.71 | DRUG MATRIX | |||||
| Membrane-associated progesterone receptor component 1 | Membrane receptor | Ki | 7.44 | DRUG MATRIX |
External reference:
| ID | Source |
|---|---|
| Q1J152VB1P | UNII |
| N0000166541 | NUI |
| D01778 | KEGG_DRUG |
| 611-75-6 | SECONDARY_CAS_RN |
| C0006220 | UMLSCUI |
| CHEBI:77032 | CHEBI |
| CHEMBL253376 | ChEMBL_ID |
| CHEMBL1319139 | ChEMBL_ID |
| DB09019 | DRUGBANK_ID |
| D001964 | MESH_DESCRIPTOR_UI |
| 2584 | INN_ID |
| 2442 | PUBCHEM_CID |
| 11218 | IUPHAR_LIGAND_ID |
| 1601 | RXNORM |
| NOCODE | MMSL |
| 003678 | NDDF |
| 003679 | NDDF |
| 412102008 | SNOMEDCT_US |
| 708561003 | SNOMEDCT_US |
| 846647005 | SNOMEDCT_US |
Pharmaceutical products:
None