moxifloxacin 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | PK/Tox | Related Drugs | BioActivity |

Stem definitionDrug idCAS RN
antibacterials, nalidixic acid derivatives 1854 151096-09-2

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • avelox
  • moxifloxacin
  • moxifloxacin hydrochloride
  • avolex
  • moxeza
  • moxifloxacine
  • moxifloxacin HCl
A fluoroquinolone that acts as an inhibitor of DNA TOPOISOMERASE II and is used as a broad-spectrum antibacterial agent.
  • Molecular weight: 401.44
  • Formula: C21H24FN3O4
  • CLOGP: -0.12
  • LIPINSKI: 0
  • HAC: 7
  • HDO: 2
  • TPSA: 82.11
  • ALOGS: -3.38
  • ROTB: 4
  • Status: OFP
    • Legend:
    OFP - off patent
    OFM - off market
    ONP - on patent

Drug dosage:

DoseUnitRoute
0.40 g O
0.40 g P

ADMET properties:

PropertyValueReference
BDDCS (Biopharmaceutical Drug Disposition Classification System) 3 Benet LZ, Broccatelli F, Oprea TI
S (Water solubility) 27.50 mg/mL Benet LZ, Broccatelli F, Oprea TI
EoM (Fraction excreted unchanged in urine) 22 % Benet LZ, Broccatelli F, Oprea TI
MRTD (Maximum Recommended Therapeutic Daily Dose) 14.23 µM/kg/day Contrera JF, Matthews EJ, Kruhlak NL, Benz RD
BA (Bioavailability) 86 % Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H
Vd (Volume of distribution) 1.40 L/kg Lombardo F, Berellini G, Obach RS
CL (Clearance) 2.40 mL/min/kg Lombardo F, Berellini G, Obach RS
fu (Fraction unbound in plasma) 0.60 % Lombardo F, Berellini G, Obach RS
t_half (Half-life) 8.20 hours Lombardo F, Berellini G, Obach RS

Predicted pharmacokinetic/toxicological properties (PK-AZ):

PropertyDescriptionValueUnitConfidenceSimilarity
azlogd74 LogD at pH 7.4 -0.339 Moderate 0.72
caco2-efflux Caco-2 efflux ratio (BA/AB) 3.639 Moderate 0.72
caco2-intrinsic-papp Caco-2 intrinsic apparent permeability 4.989 10^-6 cm/s Moderate 0.72
dh-clint Dog hepatocyte intrinsic clearance 1.125 uL/min/10^6 cells Moderate 0.72
dppb Dog plasma protein binding (% unbound) 85.510 % Moderate 0.72
fcs-ppb Fetal calf serum protein binding (% unbound) 84.120 % Moderate 0.72
herg hERG pIC50 4.418 pIC50 Moderate 0.72
hh-clint Human hepatocyte intrinsic clearance 0.962 uL/min/10^6 cells Moderate 0.72
hlm-clint Human liver microsomal intrinsic clearance 3.055 uL/min/mg protein Moderate 0.72
hppb Human plasma protein binding (% unbound) 88.610 % Moderate 0.72
kinase-safety-class GRK2,PDK1,PDK2,PDK4 4
kinase-selectivity-class AXL,CDK9,DYRK1B,EIF2AK3,GRK2,MAPK7,PRKDC,STK33,TTK 9
mdck-mdr1-bcrp-efflux MDCK-MDR1-BCRP efflux ratio 4.009 High 1
mdck-mdr1-efflux MDCK-MDR1 efflux ratio 9.550 Moderate 0.72
mh-clint Mouse hepatocyte intrinsic clearance 3.373 Moderate 0.72
mppb Mouse plasma protein binding (% unbound) 80.830 Moderate 0.72
nih-mdck-mdr1-efflux NIH MDCK-MDR1 efflux ratio 16.596 Moderate 0.72
pfas-class PFAS structural alert (1 = True, 0 = False) 0
pld-class Phospholipidosis risk class (1 = positive, 0 = negative) 1 High 1
pppb Pig plasma protein binding (% unbound) 88.910 % Moderate 0.72
rat-kpuu-brain Rat brain Kpuu 0.089 % High 1
rh-clint Rat hepatocyte intrinsic clearance 1.109 uL/min/10^6 cells Moderate 0.72
rh-fuinc Rat hepatocyte fraction unbound in incubation 88.680 % Moderate 0.72
rppb Rat plasma protein binding (% unbound) 73.050 % Moderate 0.72
solubility-dd Solubility at pH 7.4 in DMSO 895.365 uM Moderate 0.72

Approvals:

DateAgencyCompanyOrphan
Dec. 10, 1999 FDA BAYER HLTHCARE

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Drug hypersensitivity 879.65 12.61 1447 72552 462162 90092286
Asthma 785.71 12.61 977 73022 241183 90313265
Wheezing 510.27 12.61 787 73212 237293 90317155
Oedema 470.21 12.61 691 73308 199604 90354844
Iris transillumination defect 393.78 12.61 72 73927 65 90554383
Nasal oedema 364.85 12.61 153 73846 6431 90548017
Food allergy 338.98 12.61 228 73771 25250 90529198
Drug resistance 282.60 12.61 219 73780 30230 90524218
Asthma-chronic obstructive pulmonary disease overlap syndrome 275.32 12.61 115 73884 4784 90549664
Toxic anterior segment syndrome 273.86 12.61 93 73906 2157 90552291
Contrast media allergy 267.16 12.61 99 73900 2982 90551466
Total lung capacity increased 259.32 12.61 111 73888 4910 90549538
Respiratory tract infection 254.00 12.61 276 73723 58802 90495646
Immunodeficiency 251.77 12.61 238 73761 42996 90511452
Temperature regulation disorder 224.52 12.61 143 73856 14436 90540012
Pneumonia 215.89 12.61 1060 72939 636999 89917449
Prescribed overdose 214.70 12.61 327 73672 97298 90457150
Endophthalmitis 214.04 12.61 95 73904 4590 90549858
Nasal polyps 191.01 12.61 116 73883 10764 90543684
Sarcoidosis 185.34 12.61 113 73886 10560 90543888
Foetal death 177.10 12.61 142 73857 20581 90533867
Corneal oedema 171.90 12.61 63 73936 1838 90552610
Vomiting 162.23 12.61 1149 72850 787144 89767304
Hypopyon 156.80 12.61 49 73950 865 90553583
Upper respiratory tract infection 149.15 12.61 326 73673 127992 90426456
Rhinitis allergic 143.40 12.61 115 73884 16670 90537778
Loss of employment 134.63 12.61 60 73939 2927 90551521
Rash erythematous 133.21 12.61 211 73788 64893 90489555
Cardiac murmur 131.20 12.61 113 73886 18081 90536367
Hyperhidrosis 125.34 12.61 316 73683 135989 90418459
Obliterative bronchiolitis 124.52 12.61 55 73944 2626 90551822
Bronchiectasis 120.66 12.61 118 73881 22212 90532236
Fluid retention 112.97 12.61 233 73766 87858 90466590
Jaundice cholestatic 112.75 12.61 81 73918 9962 90544486
Drug intolerance 108.99 12.61 681 73318 446910 90107538
Paradoxical drug reaction 107.75 12.61 64 73935 5702 90548746
Hypomania 102.74 12.61 73 73926 8824 90545624
Dyspnoea 101.32 12.61 1131 72868 879824 89674624
Corneal infiltrates 99.67 12.61 24 73975 147 90554301
Product dose omission issue 97.05 12.61 59 73940 291628 90262820
Intentional product misuse 96.62 12.61 221 73778 89383 90465065
Cough 94.58 12.61 569 73430 368393 90186055
Corneal opacity 92.90 12.61 33 73966 878 90553570
Psoriasis 92.33 12.61 298 73701 147456 90406992
Electrocardiogram QT prolonged 92.13 12.61 191 73808 72265 90482183
Lung neoplasm malignant 91.61 12.61 106 73893 24167 90530281
Visual acuity reduced 91.33 12.61 104 73895 23306 90531142
Eye pain 87.39 12.61 141 73858 44027 90510421
Torsade de pointes 87.25 12.61 83 73916 15099 90539349
Thrombocytopenia 86.74 12.61 369 73630 208356 90346092
Fall 86.27 12.61 164 73835 481646 90072802
Bursitis 85.41 12.61 269 73730 131385 90423063
Nicotine dependence 84.69 12.61 32 73967 1018 90553430
Sputum purulent 83.65 12.61 34 73965 1318 90553130
Drug reaction with eosinophilia and systemic symptoms 79.87 12.61 133 73866 42625 90511823
Corneal epithelium defect 78.73 12.61 25 73974 466 90553982
Schizophrenia 77.21 12.61 77 73922 14837 90539611
Iris hypopigmentation 76.90 12.61 14 73985 12 90554436
Hepatic enzyme increased 76.27 12.61 530 73469 360206 90194242
Hepatotoxicity 74.39 12.61 134 73865 45708 90508740
Liver disorder 74.32 12.61 243 73756 121026 90433422
Oesophageal spasm 72.62 12.61 41 73958 3320 90551128
Toxicity to various agents 72.27 12.61 77 73922 287769 90266679
C-reactive protein 71.64 12.61 107 73892 31260 90523188
Musculoskeletal injury 70.25 12.61 18 73981 147 90554301
Hypertension 70.13 12.61 624 73375 456908 90097540
Malaise 69.75 12.61 758 73241 585228 89969220
Death 69.58 12.61 170 73829 456381 90098067
Pigment dispersion syndrome 67.23 12.61 11 73988 0 90554448
Ulcerative keratitis 66.28 12.61 39 73960 3414 90551034
Urinary tract infection 63.94 12.61 94 73905 305538 90248910
Hepatic steatosis 63.82 12.61 111 73888 36834 90517614
Secondary immunodeficiency 63.00 12.61 32 73967 2094 90552354
Acinetobacter infection 61.77 12.61 31 73968 1977 90552471
Injection site pain 60.79 12.61 33 73966 173666 90380782
Dehydration 59.69 12.61 43 73956 194404 90360044
Coeliac disease 59.54 12.61 120 73879 44490 90509958
Psychotic disorder 59.47 12.61 98 73901 31132 90523316
Oesophageal pain 57.81 12.61 39 73960 4335 90550113
Chest pain 56.92 12.61 451 73548 319194 90235254
Hypersensitivity 56.30 12.61 593 73406 454084 90100364
Hypotension 56.24 12.61 113 73886 325284 90229164
Anterior chamber cell 54.23 12.61 21 73978 715 90553733
Treatment failure 53.66 12.61 428 73571 303500 90250948
Product use issue 52.59 12.61 454 73545 329465 90224983
Injection site erythema 51.75 12.61 9 73990 98493 90455955
Chronic obstructive pulmonary disease 51.72 12.61 155 73844 73674 90480774
Dysbiosis 51.55 12.61 26 73973 1676 90552772
Vitritis 49.89 12.61 25 73974 1589 90552859
Conjunctival hyperaemia 48.58 12.61 31 73968 3138 90551310
Lymphoedema 48.48 12.61 58 73941 13695 90540753
Keratitis fungal 47.87 12.61 14 73985 195 90554253
Lower limb fracture 47.34 12.61 165 73834 84848 90469600
Product prescribing issue 46.57 12.61 44 73955 7935 90546513
Dysphoria 45.95 12.61 39 73960 6115 90548333
Iris atrophy 44.84 12.61 12 73987 118 90554330
Mental disorder 44.40 12.61 88 73911 32230 90522218
Deep vein thrombosis postoperative 44.36 12.61 143 73856 70666 90483782
Tuberculoma of central nervous system 43.80 12.61 15 73984 357 90554091
Forced expiratory volume decreased 43.76 12.61 37 73962 5771 90548677
Alopecia 43.06 12.61 233 73766 494838 90059610
Decreased immune responsiveness 41.34 12.61 43 73956 8705 90545743
Injection site reaction 41.19 12.61 12 73987 92068 90462380
Fatigue 40.93 12.61 680 73319 1153343 89401105
Malignant neoplasm progression 40.88 12.61 18 73981 106852 90447596
Corneal perforation 39.94 12.61 16 73983 597 90553851
Cerebrovascular accident 39.66 12.61 26 73973 123507 90430941
Suicide attempt 39.37 12.61 7 73992 75392 90479056
Corneal disorder 39.03 12.61 23 73976 2019 90552429
Obstructive airways disorder 38.67 12.61 73 73926 25796 90528652
Sleep disorder due to general medical condition, hypersomnia type 38.65 12.61 23 73976 2056 90552392
Anterior chamber disorder 38.38 12.61 11 73988 142 90554306
Anaemia 38.38 12.61 153 73846 352649 90201799
Photophobia 38.17 12.61 65 73934 21204 90533244
Pain in extremity 38.09 12.61 214 73785 450315 90104133
Acute kidney injury 38.07 12.61 134 73865 320253 90234195
Autoimmune disorder 37.69 12.61 143 73856 76601 90477847
Injection site swelling 37.50 12.61 3 73996 59836 90494612
Somnolence 37.50 12.61 71 73928 209013 90345435
Mycobacterium abscessus infection 37.25 12.61 18 73981 1057 90553391
Mycobacterium avium complex infection 36.98 12.61 29 73970 4069 90550379
Punctate keratitis 35.91 12.61 16 73983 780 90553668
Sciatica 35.89 12.61 171 73828 101211 90453237
Bradycardia 35.59 12.61 12 73987 83835 90470613
Tinnitus 35.55 12.61 96 73903 43006 90511442
Off label use 35.11 12.61 1161 72838 1101091 89453357
Blood bilirubin increased 35.04 12.61 96 73903 43374 90511074
Ocular hyperaemia 34.92 12.61 82 73917 33716 90520732
Tendon pain 34.85 12.61 27 73972 3721 90550727
Non-infectious endophthalmitis 34.71 12.61 12 73987 294 90554154
Gait disturbance 34.37 12.61 104 73895 260392 90294056
Atrial fibrillation 34.34 12.61 35 73964 133576 90420872
Eye inflammation 34.28 12.61 37 73962 7814 90546634
Persistent corneal epithelial defect 34.17 12.61 7 73992 17 90554431
Liver function test increased 32.92 12.61 14 73985 84841 90469607
Lung disorder 32.66 12.61 222 73777 149661 90404787
Overdose 32.25 12.61 230 73769 157479 90396969
Disseminated mycobacterium avium complex infection 32.15 12.61 11 73988 261 90554187
Stenotrophomonas infection 32.12 12.61 22 73977 2507 90551941
Ototoxicity 32.08 12.61 20 73979 1944 90552504
Lip dry 31.99 12.61 165 73834 100790 90453658
Anaphylactic reaction 31.98 12.61 149 73850 87375 90467073
Intraocular pressure increased 31.98 12.61 34 73965 7059 90547389
Seizure 31.83 12.61 47 73952 152582 90401866
Coma 31.52 12.61 10 73989 72622 90481826
Peripheral venous disease 31.50 12.61 144 73855 83777 90470671
Colitis 31.49 12.61 9 73990 69933 90484515
COVID-19 31.46 12.61 56 73943 168787 90385661
Sepsis 31.42 12.61 62 73937 179752 90374696
Bronchitis chronic 31.27 12.61 28 73971 4715 90549733
Iridocyclitis 31.09 12.61 25 73974 3636 90550812
Memory impairment 30.34 12.61 73 73926 197171 90357277
Factor V deficiency 30.05 12.61 8 73991 77 90554371
Facet joint syndrome 29.93 12.61 159 73840 98230 90456218
Pathogen resistance 29.88 12.61 35 73964 8080 90546368
Vaccination site haemorrhage 29.79 12.61 7 73992 38 90554410
Joint swelling 29.61 12.61 576 73423 502724 90051724
Inappropriate schedule of product administration 29.52 12.61 48 73951 149885 90404563
Neck pain 29.12 12.61 30 73969 113933 90440515
Corneal deposits 28.56 12.61 11 73988 369 90554079
Road traffic accident 28.14 12.61 167 73832 107459 90446989
Injection site pruritus 28.10 12.61 5 73994 53829 90500619
C-reactive protein abnormal 27.91 12.61 189 73810 127240 90427208
Choroiditis 27.87 12.61 10 73989 274 90554174
Anterior chamber inflammation 27.49 12.61 11 73988 409 90554039
Skin reaction 27.29 12.61 52 73947 18501 90535947
Immune reconstitution inflammatory syndrome 27.07 12.61 31 73968 6988 90547460
Multiple sclerosis relapse 26.99 12.61 5 73994 52300 90502148
Optic neuritis 26.50 12.61 36 73963 9642 90544806
Rhabdomyolysis 26.24 12.61 5 73994 51251 90503197
Allergy to metals 26.09 12.61 14 73985 1026 90553422
Neutropenia 26.08 12.61 95 73904 224809 90329639
Cholelithiasis 25.91 12.61 98 73901 52408 90502040
Taste disorder 25.79 12.61 9 73990 61537 90492911
Arthropathy 25.77 12.61 184 73815 366058 90188390
Febrile neutropenia 25.64 12.61 57 73942 158292 90396156
Gastroenteritis staphylococcal 25.29 12.61 7 73992 79 90554369
No adverse event 25.14 12.61 12 73987 67970 90486478
X-ray abnormal 25.14 12.61 88 73911 45336 90509112
Blood immunoglobulin M increased 25.04 12.61 15 73984 1357 90553091
Infusion related reaction 24.84 12.61 478 73521 416302 90138146
Eye infection staphylococcal 24.82 12.61 7 73992 85 90554363
Hyperkalaemia 24.75 12.61 11 73988 64953 90489495
Cognitive disorder 24.54 12.61 13 73986 69394 90485054
Blood creatinine increased 24.45 12.61 28 73971 101358 90453090
Corneal flap complication 24.45 12.61 4 73995 0 90554448
Vision blurred 24.40 12.61 164 73835 110129 90444319
Epilepsy 24.16 12.61 19 73980 82187 90472261
Nail disorder 24.13 12.61 9 73990 59058 90495390
Exposure during pregnancy 24.06 12.61 299 73700 238111 90316337
Blood immunoglobulin A decreased 24.03 12.61 16 73983 1740 90552708
Sputum discoloured 23.88 12.61 52 73947 20339 90534109
Surgery 23.80 12.61 4 73995 44883 90509565
Therapeutic response decreased 23.63 12.61 23 73976 89706 90464742
Systemic lupus erythematosus 23.48 12.61 186 73813 361710 90192738
Eczema 23.44 12.61 7 73992 52863 90501585
Retinal ischaemia 23.20 12.61 10 73989 450 90553998
Retinal haemorrhage 23.15 12.61 26 73973 5738 90548710
Pemphigus 23.10 12.61 164 73835 326700 90227748
Infective keratitis 23.10 12.61 6 73993 52 90554396
Skin injury 23.09 12.61 17 73982 2171 90552277
Therapeutic product effect incomplete 23.08 12.61 81 73918 193815 90360633
Night sweats 23.05 12.61 182 73817 128584 90425864
Unevaluable event 23.01 12.61 8 73991 54840 90499608
Vitreous opacities 22.99 12.61 10 73989 460 90553988
Encephalopathy 22.80 12.61 5 73994 46439 90508009
Foreign body sensation in eyes 22.79 12.61 20 73979 3280 90551168
Respiratory moniliasis 22.73 12.61 8 73991 207 90554241
Thrombosis 22.73 12.61 16 73983 73235 90481213
Contraindicated product administered 22.55 12.61 377 73622 319762 90234686
Onychomadesis 22.48 12.61 5 73994 45993 90508455
Musculoskeletal pain 22.39 12.61 226 73773 171025 90383423
Cataract 22.26 12.61 117 73882 71975 90482473
Type 2 lepra reaction 22.24 12.61 6 73993 61 90554387
Fibrin 22.21 12.61 4 73995 3 90554445
Balance disorder 22.15 12.61 28 73971 97052 90457396
Illness 21.60 12.61 21 73978 81948 90472500
Toxic epidermal necrolysis 21.57 12.61 67 73932 32461 90521987
Mediastinal effusion 21.41 12.61 6 73993 71 90554377
Pain 21.20 12.61 1005 72994 995336 89559112
Neuropathy peripheral 21.01 12.61 187 73812 136783 90417665
Rash 20.94 12.61 821 73178 795279 89759169
Product monitoring error 20.87 12.61 22 73977 4522 90549926
Dry skin 20.51 12.61 25 73974 88048 90466400
Maternal exposure timing unspecified 20.51 12.61 52 73947 22431 90532017
Herpes zoster 20.50 12.61 140 73859 94504 90459944
Oral mucosal hypertrophy 20.44 12.61 5 73994 33 90554415
Swelling 20.10 12.61 232 73767 418826 90135622
Blindness unilateral 20.01 12.61 28 73971 7708 90546740
Accidental exposure to product 19.93 12.61 5 73994 42361 90512087
Hot flush 19.80 12.61 12 73987 59476 90494972
Hypoglycaemia 19.47 12.61 17 73982 69831 90484617
Corneal abscess 19.39 12.61 5 73994 42 90554406
Cardiac arrest 19.36 12.61 35 73964 104900 90449548
Arthralgia 19.35 12.61 486 73513 778036 89776412
Cardio-respiratory arrest 19.31 12.61 14 73985 63126 90491322
Back injury 19.22 12.61 7 73992 46615 90507833
Immune reconstitution inflammatory syndrome associated tuberculosis 19.20 12.61 9 73990 494 90553954
White blood cell count decreased 19.09 12.61 71 73928 167038 90387410
Vitreous floaters 19.05 12.61 27 73972 7522 90546926
Tendonitis 19.05 12.61 49 73950 21323 90533125
Product quality issue 19.03 12.61 22 73977 79303 90475145
Maternal exposure during pregnancy 19.00 12.61 195 73804 359868 90194580
Pneumonia aspiration 18.93 12.61 5 73994 40935 90513513
Obesity 18.81 12.61 149 73850 105358 90449090
Keratitis bacterial 18.70 12.61 5 73994 49 90554399
Corneal transplant 18.66 12.61 8 73991 355 90554093
Influenza like illness 18.65 12.61 23 73976 80588 90473860
Transient ischaemic attack 18.64 12.61 6 73993 43170 90511278
Muscular weakness 18.63 12.61 96 73903 206570 90347878
Diarrhoea 18.61 12.61 605 73394 938585 89615863
Onychomycosis 18.40 12.61 4 73995 37372 90517076
Sleep disorder due to general medical condition, insomnia type 18.36 12.61 173 73826 128521 90425927
Lung neoplasm 18.36 12.61 25 73974 6710 90547738
Gonioscopy abnormal 18.33 12.61 3 73996 0 90554448
Bronchial ulceration 18.33 12.61 3 73996 0 90554448
Product used for unknown indication 18.33 12.61 10 73989 757 90553691
Nosocomial infection 18.27 12.61 14 73985 1899 90552549
Haemostasis 18.23 12.61 8 73991 376 90554072
Increased viscosity of bronchial secretion 18.11 12.61 8 73991 382 90554066
Sleep apnoea syndrome 18.00 12.61 62 73937 31685 90522763
Epistaxis 17.95 12.61 26 73973 85099 90469349
Abortion spontaneous 17.86 12.61 11 73988 54045 90500403
Loss of consciousness 17.77 12.61 57 73942 140181 90414267
Morganella infection 17.75 12.61 10 73989 806 90553642
Breast cancer 17.68 12.61 11 73988 53750 90500698
Corneal erosion 17.58 12.61 8 73991 410 90554038
Vanishing bile duct syndrome 17.58 12.61 12 73987 1360 90553088
Metabolic acidosis 17.48 12.61 12 73987 55664 90498784
Corneal neovascularisation 17.43 12.61 6 73993 145 90554303
Tachycardia 17.36 12.61 68 73931 157605 90396843
Blepharospasm 17.35 12.61 12 73987 55433 90499015
Finger deformity 17.29 12.61 3 73996 32894 90521554
Tender joint count 17.20 12.61 12 73987 1409 90553039
Lymphadenitis 17.20 12.61 19 73980 4118 90550330
Swollen joint count increased 17.14 12.61 152 73847 111054 90443394
Iodine allergy 16.99 12.61 10 73989 876 90553572
Trichophytosis 16.94 12.61 5 73994 72 90554376
Glaucoma 16.89 12.61 46 73953 20709 90533739
Multiple fractures 16.87 12.61 29 73970 9533 90544915
Porphyria acute 16.84 12.61 42 73957 17933 90536515
Paraneoplastic syndrome 16.83 12.61 9 73990 655 90553793
Injection site bruising 16.79 12.61 11 73988 52296 90502152
Aspergillus infection 16.75 12.61 31 73968 10792 90543656
Blood immunoglobulin G increased 16.61 12.61 16 73983 2956 90551492
Skin odour abnormal 16.59 12.61 13 73986 1822 90552626
Caffeine allergy 16.54 12.61 4 73995 25 90554423
Pulmonary hypertension 16.52 12.61 7 73992 42516 90511932
Mycobacterial infection 16.49 12.61 14 73985 2196 90552252
Asthenia 16.44 12.61 322 73677 533429 90021019
Metastases to thyroid 16.41 12.61 4 73995 26 90554422
Retinal vasculitis 16.32 12.61 12 73987 1529 90552919
Disorganised speech 16.28 12.61 13 73986 1872 90552576
Eosinophilic pneumonia acute 16.20 12.61 9 73990 706 90553742
Convulsions local 16.15 12.61 4 73995 28 90554420
Loss of personal independence in daily activities 16.09 12.61 57 73942 136048 90418400
Mucosal inflammation 16.09 12.61 14 73985 57611 90496837
Orthostatic hypotension 16.06 12.61 7 73992 41820 90512628
Peripheral nerve injury 15.93 12.61 9 73990 730 90553718
Macular cyst 15.79 12.61 4 73995 31 90554417
Incorrect dose administered 15.78 12.61 25 73974 78905 90475543
Metastatic malignant melanoma 15.76 12.61 12 73987 1612 90552836
Coronary artery disease 15.75 12.61 4 73995 33619 90520829
Embolism venous 15.70 12.61 17 73982 3603 90550845
Implant site hypersensitivity 15.68 12.61 4 73995 32 90554416
Hospitalisation 15.58 12.61 53 73946 128047 90426401
Hyperalbuminaemia 15.57 12.61 4 73995 33 90554415
Respiratory arrest 15.54 12.61 4 73995 33307 90521141
Cataract operation 15.49 12.61 22 73977 6141 90548307
Hyphaema 15.38 12.61 7 73992 359 90554089
Upper respiratory tract irritation 15.37 12.61 6 73993 209 90554239
Biopsy colon abnormal 15.23 12.61 5 73994 104 90554344
Weight decreased 15.01 12.61 219 73780 379691 90174757
Gastrointestinal haemorrhage 15.01 12.61 32 73967 90216 90464232
Agranulocytosis 14.87 12.61 5 73994 34997 90519451
Nephrolithiasis 14.86 12.61 11 73988 49074 90505374
Syncope 14.74 12.61 57 73942 132606 90421842
Drug-induced liver injury 14.73 12.61 125 73874 90193 90464255
Haematochezia 14.62 12.61 22 73977 70891 90483557
Vitreal cells 14.60 12.61 5 73994 119 90554329
Joint stiffness 14.42 12.61 26 73973 78016 90476432
Hypercalcaemia 14.36 12.61 5 73994 34235 90520213
Keratitis 14.29 12.61 17 73982 3989 90550459
General physical health deterioration 14.28 12.61 204 73795 354911 90199537
Retinal artery occlusion 14.17 12.61 13 73986 2258 90552190
Rheumatoid arthritis 14.15 12.61 392 73607 362222 90192226
Pupillary disorder 14.02 12.61 6 73993 265 90554183
Insomnia 13.96 12.61 190 73809 333284 90221164
Red blood cell count increased 13.90 12.61 16 73983 3627 90550821
Full blood count abnormal 13.88 12.61 63 73936 36534 90517914
Basal cell carcinoma 13.79 12.61 5 73994 33384 90521064
Corynebacterium infection 13.68 12.61 9 73990 959 90553489
Deafness 13.67 12.61 45 73954 22469 90531979
Atypical mycobacterial infection 13.59 12.61 11 73988 1615 90552833
Renal failure 13.48 12.61 58 73941 130949 90423499
Disseminated tuberculosis 13.45 12.61 15 73984 3284 90551164
Tendon discomfort 13.36 12.61 6 73993 298 90554150
Urinary incontinence 13.33 12.61 7 73992 37559 90516889
Feeling abnormal 13.27 12.61 81 73918 167154 90387294
Detachment of retinal pigment epithelium 13.24 12.61 7 73992 498 90553950
Hydrothorax 13.15 12.61 9 73990 1024 90553424
Forced vital capacity abnormal 13.11 12.61 4 73995 65 90554383
Rheumatic disorder 13.05 12.61 15 73984 3393 90551055
Adverse reaction 13.05 12.61 4 73995 29708 90524740
Sputum increased 13.02 12.61 14 73985 2943 90551505
Blood pressure increased 12.94 12.61 101 73898 197116 90357332
Pruritus allergic 12.89 12.61 11 73988 1737 90552711
Eyelid pain 12.85 12.61 8 73991 775 90553673
Ocular toxicity 12.81 12.61 9 73990 1068 90553380
Nocardiosis 12.81 12.61 13 73986 2557 90551891
Subcutaneous abscess 12.80 12.61 21 73978 6645 90547803
Pterygium 12.79 12.61 6 73993 330 90554118
Product use in unapproved indication 12.70 12.61 362 73637 335874 90218574
Chills 12.64 12.61 60 73939 131921 90422527

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Spirometry abnormal 288.48 13.60 116 30278 5030 42585911
Conjunctivitis allergic 269.63 13.60 115 30279 5796 42585145
Mycotic allergy 259.56 13.60 106 30288 4785 42586156
Mite allergy 256.36 13.60 106 30288 4940 42586001
Dust allergy 250.72 13.60 106 30288 5226 42585715
Visual acuity reduced 250.43 13.60 156 30238 17394 42573547
Drug resistance 237.10 13.60 196 30198 34052 42556889
Sleep disorder due to a general medical condition 223.76 13.60 145 30249 17308 42573633
Iris transillumination defect 220.76 13.60 37 30357 12 42590929
Choroiditis 217.08 13.60 67 30327 1308 42589633
Electrocardiogram QT prolonged 205.89 13.60 210 30184 47735 42543206
Eye pain 202.53 13.60 135 30259 16895 42574046
Normochromic normocytic anaemia 200.31 13.60 107 30287 8924 42582017
Toxic anterior segment syndrome 198.48 13.60 63 30331 1353 42589588
Pulmonary vasculitis 193.91 13.60 93 30301 6173 42584768
Intraocular pressure increased 188.57 13.60 92 30302 6341 42584600
Neuritis 173.51 13.60 86 30308 6134 42584807
Nodule 170.21 13.60 108 30286 12426 42578515
Corneal oedema 165.04 13.60 56 30338 1492 42589449
Endophthalmitis 162.57 13.60 74 30320 4359 42586582
Eosinophilic granulomatosis with polyangiitis 154.95 13.60 89 30305 8549 42582392
Respiratory symptom 154.07 13.60 97 30297 11009 42579932
Asthma 147.20 13.60 201 30193 62113 42528828
Neurological symptom 140.44 13.60 88 30306 9903 42581038
Delirium 138.80 13.60 179 30215 52340 42538601
Wheezing 137.46 13.60 182 30212 54599 42536342
Arteriosclerosis coronary artery 131.51 13.60 108 30286 18569 42572372
Dysphoria 129.79 13.60 55 30339 2725 42588216
Uveitis 123.77 13.60 79 30315 9179 42581762
Arteriosclerosis 122.44 13.60 102 30292 17887 42573054
Total lung capacity abnormal 119.69 13.60 60 30334 4383 42586558
Full blood count abnormal 119.43 13.60 126 30268 29750 42561191
Vasculitis 118.41 13.60 101 30293 18293 42572648
Type 2 lepra reaction 118.31 13.60 31 30363 324 42590617
Ulcerative keratitis 116.77 13.60 47 30347 2041 42588900
Productive cough 116.74 13.60 163 30231 51404 42539537
Anterior chamber cell 114.37 13.60 32 30362 436 42590505
Pulmonary alveolar haemorrhage 111.33 13.60 89 30305 14727 42576214
Paradoxical drug reaction 110.32 13.60 58 30336 4680 42586261
Obstructive airways disorder 107.20 13.60 109 30285 24650 42566291
Mental disorder 105.97 13.60 94 30300 17935 42573006
Hypopyon 105.72 13.60 31 30363 504 42590437
Ototoxicity 105.24 13.60 45 30349 2280 42588661
Keratitis fungal 101.83 13.60 25 30369 196 42590745
Antineutrophil cytoplasmic antibody positive 97.57 13.60 52 30342 4313 42586628
Haemoptysis 97.21 13.60 141 30253 46026 42544915
Loss of personal independence in daily activities 84.97 13.60 138 30256 49678 42541263
Forced expiratory volume decreased 84.74 13.60 58 30336 7572 42583369
Corneal perforation 83.48 13.60 23 30371 295 42590646
Corneal infiltrates 81.44 13.60 20 30374 157 42590784
Condition aggravated 81.07 13.60 384 30010 260370 42330571
Pulmonary fibrosis 80.13 13.60 97 30297 26584 42564357
Neuropathy peripheral 79.59 13.60 204 30190 101649 42489292
Hepatotoxicity 76.40 13.60 92 30302 25075 42565866
Product prescribing issue 74.07 13.60 51 30343 6722 42584219
Disorganised speech 72.52 13.60 30 30364 1398 42589543
Hypothyroidism 66.08 13.60 97 30297 31987 42558954
Therapeutic product effect incomplete 65.98 13.60 152 30242 70787 42520154
Product use in unapproved indication 65.74 13.60 283 30111 184173 42406768
Capillaritis 65.69 13.60 32 30362 2196 42588745
Off label use 65.57 13.60 718 29676 637617 41953324
Iris hypopigmentation 65.09 13.60 13 30381 32 42590909
Musculoskeletal injury 64.78 13.60 16 30378 129 42590812
Hypoxia 63.23 13.60 148 30246 69638 42521303
Retinal haemorrhage 62.05 13.60 43 30351 5727 42585214
Lung disorder 60.05 13.60 116 30278 47807 42543134
Vitritis 59.27 13.60 25 30369 1224 42589717
Conjunctival hyperaemia 57.69 13.60 33 30361 3143 42587798
Corneal decompensation 56.94 13.60 12 30382 42 42590899
Pathogen resistance 56.21 13.60 54 30340 11396 42579545
Iridocyclitis 54.14 13.60 28 30366 2183 42588758
Vitreous opacities 53.82 13.60 18 30376 458 42590483
Necrotising scleritis 51.52 13.60 12 30382 73 42590868
Product dose omission issue 48.14 13.60 25 30369 154340 42436601
Corneal epithelium defect 47.88 13.60 16 30378 406 42590535
Ocular hyperaemia 47.86 13.60 58 30336 15905 42575036
Painful respiration 47.52 13.60 22 30372 1347 42589594
Immune reconstitution inflammatory syndrome 46.36 13.60 46 30348 10097 42580844
Drug-induced liver injury 44.74 13.60 90 30304 38183 42552758
Mycobacterium chelonae infection 44.25 13.60 20 30374 1158 42589783
Multiple-drug resistance 42.66 13.60 38 30356 7284 42583657
Drug reaction with eosinophilia and systemic symptoms 42.28 13.60 93 30301 41982 42548959
Eye inflammation 41.87 13.60 27 30367 3191 42587750
Keratitis bacterial 41.63 13.60 11 30383 119 42590822
Visual impairment 40.75 13.60 93 30301 43020 42547921
Anterior chamber inflammation 40.66 13.60 14 30380 390 42590551
Iris atrophy 39.71 13.60 10 30384 88 42590853
Persistent corneal epithelial defect 39.18 13.60 9 30385 51 42590890
Keratic precipitates 39.18 13.60 12 30382 228 42590713
Chest injury 38.74 13.60 21 30373 1801 42589140
Thrombosis 37.68 13.60 121 30273 68390 42522551
Corneal opacity 37.29 13.60 15 30379 650 42590291
Toxicity to various agents 36.82 13.60 67 30327 229069 42361872
Drug ineffective for unapproved indication 36.56 13.60 93 30301 46070 42544871
Fall 36.43 13.60 70 30324 234450 42356491
Overdose 35.97 13.60 15 30379 105249 42485692
Vision blurred 34.35 13.60 100 30294 53599 42537342
Tuberculosis 34.10 13.60 39 30355 10060 42580881
Urethritis mycoplasmal 34.04 13.60 7 30387 21 42590920
Walking aid user 34.03 13.60 22 30372 2611 42588330
Psoas abscess 33.79 13.60 15 30379 832 42590109
Tendonitis 33.06 13.60 38 30356 9856 42581085
NPM1 gene mutation 32.55 13.60 9 30385 117 42590824
Dehydration 32.36 13.60 32 30362 141735 42449206
Conjunctival oedema 30.98 13.60 13 30381 628 42590313
Cystoid macular oedema 30.95 13.60 15 30379 1018 42589923
Eye infection fungal 30.86 13.60 12 30382 475 42590466
Hypertension 30.48 13.60 45 30349 167159 42423782
Tendon discomfort 30.01 13.60 11 30383 369 42590572
Tuberculoma of central nervous system 29.73 13.60 10 30384 259 42590682
Hypoacusis 29.43 13.60 50 30344 18652 42572289
Mycobacterium fortuitum infection 29.02 13.60 11 30383 406 42590535
Allergic fungal rhinosinusitis 28.84 13.60 7 30387 52 42590889
Diarrhoea 28.59 13.60 202 30192 460647 42130294
Death 28.53 13.60 208 30186 470977 42119964
Corneal striae 28.47 13.60 6 30388 21 42590920
Vitreous haemorrhage 28.43 13.60 20 30374 2727 42588214
Corneal scar 27.89 13.60 9 30385 204 42590737
Flat anterior chamber of eye 27.86 13.60 7 30387 61 42590880
Thalamic infarction 27.77 13.60 13 30381 816 42590125
Corneal disorder 27.64 13.60 14 30380 1045 42589896
Hypotension 27.54 13.60 93 30301 257538 42333403
Tuberculosis of central nervous system 27.37 13.60 9 30385 217 42590724
Anxiety 27.34 13.60 161 30233 118399 42472542
Corynebacterium infection 26.99 13.60 13 30381 870 42590071
Diastasis recti abdominis 26.81 13.60 7 30387 72 42590869
Skin injury 26.81 13.60 19 30375 2622 42588319
Herpes zoster meningoencephalitis 26.72 13.60 11 30383 506 42590435
Mycobacterium avium complex infection 26.69 13.60 20 30374 3007 42587934
Acoustic neuroma 26.52 13.60 8 30386 144 42590797
Skin exfoliation 26.20 13.60 77 30317 41476 42549465
Chimerism 26.20 13.60 9 30385 249 42590692
Hypotony of eye 26.16 13.60 9 30385 250 42590691
Deafness 26.00 13.60 39 30355 13101 42577840
Pseudoendophthalmitis 25.83 13.60 7 30387 84 42590857
Pigment dispersion syndrome 25.75 13.60 5 30389 10 42590931
Mycobacterium abscessus infection 25.71 13.60 12 30382 748 42590193
Fatigue 25.54 13.60 194 30200 435447 42155494
Mycobacterial peritonitis 25.50 13.60 8 30386 165 42590776
Immune reconstitution inflammatory syndrome associated tuberculosis 25.49 13.60 11 30383 570 42590371
Tendon pain 25.16 13.60 20 30374 3280 42587661
Retinal detachment 25.14 13.60 27 30367 6498 42584443
Weight increased 25.07 13.60 24 30370 107959 42482982
Scleromalacia 25.03 13.60 6 30388 42 42590899
Culture negative 24.99 13.60 4 30390 0 42590941
Bronchiolitis obliterans syndrome 24.55 13.60 9 30385 302 42590639
Cerebrovascular accident 24.48 13.60 20 30374 97140 42493801
Acute kidney injury 24.25 13.60 158 30236 367179 42223762
Pulmonary embolism 23.56 13.60 156 30238 119456 42471485
Foreign body sensation in eyes 23.11 13.60 12 30382 943 42589998
Vitreal cells 22.96 13.60 6 30388 62 42590879
Deafness neurosensory 22.94 13.60 20 30374 3726 42587215
Papilloma 22.89 13.60 9 30385 367 42590574
Trichoglossia 22.64 13.60 9 30385 378 42590563
Cataract 22.53 13.60 60 30334 30544 42560397
Intentional product misuse 22.50 13.60 8 30386 61892 42529049
Oral candidiasis 21.99 13.60 38 30356 14367 42576574
Detachment of retinal pigment epithelium 21.79 13.60 10 30384 600 42590341
Haemophagocytic lymphohistiocytosis 21.47 13.60 43 30351 18179 42572762
Fibrin 21.33 13.60 4 30390 6 42590935
Optic neuritis 21.21 13.60 20 30374 4122 42586819
Myocardial infarction 21.04 13.60 35 30359 123974 42466967
Eye abscess 21.01 13.60 7 30387 176 42590765
Deafness unilateral 20.94 13.60 15 30379 2104 42588837
Corneal transplant 20.55 13.60 6 30388 96 42590845
Suicide attempt 20.46 13.60 4 30390 46096 42544845
Retinal ischaemia 20.43 13.60 9 30385 490 42590451
Photophobia 20.37 13.60 27 30367 8092 42582849
Nasal crusting 20.14 13.60 9 30385 507 42590434
Sepsis 19.92 13.60 74 30320 199260 42391681
Choroidal detachment 19.75 13.60 9 30385 531 42590410
Prostate cancer 19.55 13.60 4 30390 44639 42546302
FEV1/FVC ratio abnormal 19.37 13.60 5 30389 49 42590892
Sitting disability 19.27 13.60 7 30387 229 42590712
Corneal deposits 19.15 13.60 7 30387 233 42590708
Atypical mycobacterial infection 19.11 13.60 12 30382 1354 42589587
Infective keratitis 18.77 13.60 5 30389 56 42590885
Blepharitis allergic 18.74 13.60 3 30391 0 42590941
Vitreous haze 18.61 13.60 5 30389 58 42590883
Product delivery mechanism issue 18.45 13.60 7 30387 259 42590682
Aortic aneurysm 18.33 13.60 25 30369 7698 42583243
Tachyarrhythmia 18.28 13.60 18 30376 3914 42587027
Scleral thinning 18.18 13.60 4 30390 18 42590923
Hypersensitivity 17.80 13.60 100 30294 72270 42518671
Pulmonary venous thrombosis 17.71 13.60 6 30388 159 42590782
Blood immunoglobulin G decreased 17.59 13.60 14 30380 2300 42588641
Donor leukocyte infusion 17.42 13.60 5 30389 75 42590866
Vitreous floaters 17.17 13.60 18 30376 4212 42586729
Atypical mycobacterium test positive 17.12 13.60 5 30389 80 42590861
Haematospermia 16.78 13.60 7 30387 333 42590608
Toxic optic neuropathy 16.76 13.60 10 30384 1030 42589911
Phosphorus metabolism disorder 16.66 13.60 3 30391 3 42590938
Anterior chamber flare 16.52 13.60 5 30389 91 42590850
Masticatory pain 16.45 13.60 4 30390 30 42590911
Cataract subcapsular 16.21 13.60 8 30386 565 42590376
Acute myeloid leukaemia recurrent 16.18 13.60 16 30378 3496 42587445
Therapeutic product effect decreased 16.16 13.60 4 30390 39146 42551795
Nervous system disorder 16.14 13.60 37 30357 17158 42573783
Ocular icterus 15.93 13.60 15 30379 3086 42587855
Mycobacterial infection 15.85 13.60 14 30380 2654 42588287
Memory impairment 15.84 13.60 8 30386 50214 42540727
Tinnitus 15.80 13.60 51 30343 28887 42562054
Headache 15.74 13.60 103 30291 239266 42351675
Treatment failure 15.71 13.60 87 30307 62537 42528404
Somnolence 15.70 13.60 50 30344 141055 42449886
Incoherent 15.66 13.60 18 30376 4667 42586274
Bradycardia 15.57 13.60 23 30371 85461 42505480
Lethargy 15.50 13.60 7 30387 46883 42544058
Weight decreased 15.50 13.60 86 30308 207862 42383079
Metamorphopsia 15.50 13.60 8 30386 621 42590320
Choroidal haematoma 15.45 13.60 3 30391 6 42590935
Antibiotic associated colitis 15.45 13.60 3 30391 6 42590935
Mechanical urticaria 15.34 13.60 5 30389 117 42590824
Axonal neuropathy 15.18 13.60 10 30384 1225 42589716
Cellulitis 15.11 13.60 13 30381 61572 42529369
Retinal vasculitis 15.10 13.60 8 30386 655 42590286
Nasal inflammation 15.00 13.60 7 30387 436 42590505
Eye infection 14.99 13.60 17 30377 4344 42586597
Generalised bullous fixed drug eruption 14.94 13.60 7 30387 440 42590501
Psoriasis 14.94 13.60 8 30386 48596 42542345
Eye irritation 14.91 13.60 28 30366 11290 42579651
Non-infectious endophthalmitis 14.89 13.60 6 30388 261 42590680
Tendon disorder 14.80 13.60 15 30379 3374 42587567
Contraindicated product prescribed 14.71 13.60 8 30386 691 42590250
Bronchial irritation 14.69 13.60 4 30390 49 42590892
Pulmonary cavitation 14.68 13.60 10 30384 1294 42589647
Malignant neoplasm progression 14.60 13.60 35 30359 108365 42482576
Neurilemmoma benign 14.59 13.60 3 30391 9 42590932
Rheumatoid arthritis 14.57 13.60 6 30388 42434 42548507
Sputum discoloured 14.52 13.60 26 30368 10106 42580835
Injection site pain 14.42 13.60 12 30382 57786 42533155
Emotional distress 14.41 13.60 34 30360 16059 42574882
Blood culture negative 14.33 13.60 4 30390 54 42590887
Allogenic stem cell transplantation 14.14 13.60 5 30389 151 42590790
Respiratory rate increased 14.12 13.60 27 30367 11035 42579906
Iritis 14.01 13.60 11 30383 1771 42589170
Keratitis 13.96 13.60 11 30383 1780 42589161
Incorrect product administration duration 13.91 13.60 19 30375 5861 42585080
Scleritis 13.83 13.60 8 30386 778 42590163
Lung diffusion disorder 13.61 13.60 5 30389 169 42590772

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Asthma 872.43 11.91 1084 95696 249207 110243312
Drug hypersensitivity 753 11.91 1390 95390 452700 110039819
Wheezing 663.07 11.91 958 95822 254272 110238247
Iris transillumination defect 550.58 11.91 103 96677 104 110492415
Oedema 441.67 11.91 715 96065 209261 110283258
Toxic anterior segment syndrome 419.36 11.91 145 96635 3309 110489210
Nasal oedema 352.24 11.91 154 96626 6685 110485834
Endophthalmitis 328.79 11.91 155 96625 8032 110484487
Corneal oedema 316.06 11.91 115 96665 3058 110489461
Drug resistance 289.40 11.91 299 96481 56075 110436444
Visual acuity reduced 275.16 11.91 227 96553 31946 110460573
Spirometry abnormal 274.10 11.91 121 96659 5376 110487143
Total lung capacity increased 253.21 11.91 112 96668 5000 110487519
Hypopyon 236.85 11.91 76 96704 1364 110491155
Asthma-chronic obstructive pulmonary disease overlap syndrome 236.13 11.91 114 96666 6230 110486289
Conjunctivitis allergic 235.40 11.91 117 96663 6814 110485705
Dust allergy 232.97 11.91 111 96669 5890 110486629
Mite allergy 227.30 11.91 108 96672 5695 110486824
Mycotic allergy 221.63 11.91 107 96673 5847 110486672
Choroiditis 220.34 11.91 74 96706 1541 110490978
Electrocardiogram QT prolonged 217.99 11.91 363 96417 108597 110383922
Respiratory tract infection 205.04 11.91 282 96498 71335 110421184
Contrast media allergy 199.06 11.91 84 96696 3339 110489180
Eye pain 191.93 11.91 228 96552 49871 110442648
Intraocular pressure increased 186.13 11.91 117 96663 10759 110481760
Paradoxical drug reaction 184.24 11.91 112 96668 9705 110482814
Ulcerative keratitis 175.44 11.91 85 96695 4681 110487838
Pulmonary vasculitis 174.58 11.91 94 96686 6466 110486053
Dysphoria 173.56 11.91 93 96687 6335 110486184
Temperature regulation disorder 168.54 11.91 117 96663 12709 110479810
Nasal polyps 167.83 11.91 118 96662 13082 110479437
Sarcoidosis 165.89 11.91 115 96665 12464 110480055
Corneal infiltrates 163.13 11.91 42 96738 324 110492195
Food allergy 156.63 11.91 134 96646 19814 110472705
Anterior chamber cell 151.10 11.91 52 96728 1169 110491350
Pneumonia 150.53 11.91 1293 95487 875421 109617098
Hepatotoxicity 147.04 11.91 226 96554 63174 110429345
Neuritis 145.53 11.91 87 96693 7312 110485207
Normochromic normocytic anaemia 143.82 11.91 107 96673 12950 110479569
Foetal death 143.04 11.91 116 96664 15929 110476590
Rhinitis allergic 141.96 11.91 121 96659 17801 110474718
Keratitis fungal 136.97 11.91 38 96742 401 110492118
Iris hypopigmentation 135.96 11.91 27 96753 47 110492472
Type 2 lepra reaction 134.45 11.91 37 96743 378 110492141
Obstructive airways disorder 130.99 11.91 181 96599 45968 110446551
Toxicity to various agents 130.31 11.91 137 96643 480418 110012101
Loss of employment 127.21 11.91 61 96719 3283 110489236
Corneal opacity 127.06 11.91 46 96734 1205 110491314
Eosinophilic granulomatosis with polyangiitis 125.44 11.91 91 96689 10595 110481924
Vomiting 123.22 11.91 1277 95503 909398 109583121
Product dose omission issue 123.02 11.91 64 96716 321718 110170801
Mental disorder 122.09 11.91 160 96620 38631 110453888
Immunodeficiency 121.94 11.91 160 96620 38678 110453841
Fall 121.32 11.91 214 96566 603268 109889251
Product prescribing issue 119.51 11.91 95 96685 12677 110479842
Corneal perforation 119.42 11.91 41 96739 915 110491604
Corneal epithelium defect 117.38 11.91 40 96740 872 110491647
Forced expiratory volume decreased 116.91 11.91 95 96685 13081 110479438
Sleep disorder due to a general medical condition 115.59 11.91 182 96598 51930 110440589
Total lung capacity abnormal 114.54 11.91 63 96717 4520 110487999
Respiratory symptom 114.51 11.91 99 96681 14846 110477673
Full blood count abnormal 112.40 11.91 187 96593 55865 110436654
Prescribed overdose 107.32 11.91 237 96543 87344 110405175
Drug reaction with eosinophilia and systemic symptoms 107.28 11.91 228 96552 81867 110410652
Dyspnoea 102.78 11.91 1445 95335 1105427 109387092
Conjunctival hyperaemia 100.46 11.91 63 96717 5768 110486751
Neurological symptom 99.08 11.91 93 96687 15515 110477004
Drug intolerance 97.98 11.91 650 96130 405862 110086657
Hypotension 97.97 11.91 194 96586 523655 109968864
Delirium 97.85 11.91 300 96480 134725 110357794
Cardiac murmur 97.49 11.91 114 96666 24514 110468005
Obliterative bronchiolitis 95.32 11.91 52 96728 3671 110488848
Arteriosclerosis coronary artery 94.03 11.91 113 96667 25005 110467514
Vitritis 93.70 11.91 46 96734 2607 110489912
Hypomania 93.52 11.91 75 96705 10135 110482384
Dehydration 92.31 11.91 66 96714 279445 110213074
Uveitis 91.84 11.91 104 96676 21606 110470913
Acute kidney injury 91.43 11.91 270 96510 635160 109857359
Nodule 88.16 11.91 125 96655 32506 110460013
Death 88.05 11.91 315 96465 698554 109793965
Antineutrophil cytoplasmic antibody positive 87.85 11.91 55 96725 5021 110487498
Productive cough 83.78 11.91 255 96525 114050 110378469
Iris atrophy 82.95 11.91 22 96758 193 110492326
Sputum purulent 82.61 11.91 38 96742 1860 110490659
Arteriosclerosis 82.38 11.91 105 96675 24662 110467857
Bronchiectasis 81.69 11.91 128 96652 36365 110456154
Lung disorder 80.78 11.91 342 96438 179705 110312814
Jaundice cholestatic 79.51 11.91 80 96700 14528 110477991
Pulmonary alveolar haemorrhage 79.30 11.91 93 96687 20057 110472462
Pigment dispersion syndrome 78.37 11.91 15 96765 19 110492500
Upper respiratory tract infection 77.38 11.91 272 96508 131056 110361463
Oesophageal spasm 77.06 11.91 45 96735 3621 110488898
Iridocyclitis 74.99 11.91 51 96729 5357 110487162
Neuropathy peripheral 73.91 11.91 332 96448 178945 110313574
Bursitis 73.06 11.91 265 96515 129653 110362866
Vasculitis 72.34 11.91 120 96660 35753 110456766
Ototoxicity 72.09 11.91 45 96735 4086 110488433
Lung neoplasm malignant 72.03 11.91 116 96664 33726 110458793
Nicotine dependence 71.89 11.91 31 96749 1300 110491219
C-reactive protein 71.55 11.91 109 96671 30222 110462297
Disorganised speech 70.64 11.91 41 96739 3262 110489257
Fluid retention 70.62 11.91 212 96568 94095 110398424
Treatment failure 69.60 11.91 448 96332 276786 110215733
Cough 68.29 11.91 660 96120 460981 110031538
Injection site pain 67.06 11.91 36 96744 177886 110314633
Urinary tract infection 67.02 11.91 114 96666 326168 110166351
Cerebrovascular accident 66.42 11.91 38 96742 181246 110311273
Immune reconstitution inflammatory syndrome 65.71 11.91 76 96704 16150 110476369
Pathogen resistance 65.32 11.91 79 96701 17593 110474926
Liver disorder 64.42 11.91 271 96509 141972 110350547
Ocular hyperaemia 64.42 11.91 120 96660 39166 110453353
Lower limb fracture 62.79 11.91 176 96604 75172 110417347
Vitreous opacities 62.53 11.91 25 96755 864 110491655
Dysbiosis 60.82 11.91 32 96748 2100 110490419
Suicide attempt 60.75 11.91 9 96771 103385 110389134
Persistent corneal epithelial defect 60.69 11.91 15 96765 96 110492423
Hypersensitivity 60.42 11.91 579 96201 403419 110089100
Tuberculoma of central nervous system 60.10 11.91 22 96758 595 110491924
Eye inflammation 58.89 11.91 55 96725 9116 110483403
Rash erythematous 58.50 11.91 181 96599 81651 110410868
Hepatic enzyme increased 58.34 11.91 480 96300 320412 110172107
Bradycardia 57.83 11.91 32 96748 155485 110337034
Corneal disorder 57.57 11.91 33 96747 2564 110489955
Capillaritis 56.78 11.91 32 96748 2407 110490112
Psoriasis 56.01 11.91 257 96523 139736 110352783
Deep vein thrombosis postoperative 55.94 11.91 145 96635 59146 110433373
Musculoskeletal injury 55.28 11.91 16 96764 199 110492320
Off label use 55.08 11.91 1708 95072 1498477 108994042
Anterior chamber disorder 54.26 11.91 15 96765 156 110492363
Oesophageal pain 54.22 11.91 41 96739 5084 110487435
Keratitis bacterial 53.48 11.91 16 96764 225 110492294
Corneal decompensation 53.46 11.91 13 96767 77 110492442
Coeliac disease 53.04 11.91 117 96663 43070 110449449
Tendon pain 52.75 11.91 44 96736 6282 110486237
Schizophrenia 52.28 11.91 79 96701 21747 110470772
Sepsis 51.54 11.91 133 96647 327213 110165306
Somnolence 51.47 11.91 115 96665 297334 110195185
Malignant neoplasm progression 50.42 11.91 47 96733 174520 110317999
Acinetobacter infection 50.27 11.91 34 96746 3539 110488980
Optic neuritis 49.89 11.91 55 96725 11092 110481427
Anaemia 49.86 11.91 278 96502 546808 109945711
Sedation 48.96 11.91 3 96777 69680 110422839
Fatigue 48.80 11.91 760 96020 1215198 109277321
Product use in unapproved indication 47.46 11.91 599 96181 446778 110045741
Autoimmune disorder 46.95 11.91 145 96635 65338 110427181
Malaise 46.90 11.91 837 95943 670982 109821537
Tinnitus 46.18 11.91 137 96643 60403 110432116
Vision blurred 45.91 11.91 229 96551 128793 110363726
Injection site erythema 45.43 11.91 13 96767 94163 110398356
Injection site reaction 45.43 11.91 11 96769 89059 110403460
Psychotic disorder 44.44 11.91 121 96659 50816 110441703
Secondary immunodeficiency 44.22 11.91 35 96745 4641 110487878
Hyperkalaemia 43.60 11.91 33 96747 135763 110356756
Torsade de pointes 43.44 11.91 74 96706 22526 110469993
Punctate keratitis 42.89 11.91 21 96759 1183 110491336
Non-infectious endophthalmitis 42.31 11.91 16 96764 475 110492044
Chest pain 42.08 11.91 509 96271 375866 110116653
Chronic obstructive pulmonary disease 41.90 11.91 198 96582 108960 110383559
COVID-19 41.37 11.91 96 96684 244964 110247555
Haemoptysis 41.34 11.91 147 96633 71207 110421312
Retinal haemorrhage 41.01 11.91 46 96734 9455 110483064
Multiple-drug resistance 40.73 11.91 54 96726 13181 110479338
Tendonitis 40.69 11.91 78 96702 26005 110466514
Decreased immune responsiveness 40.60 11.91 46 96734 9560 110482959
Drug-induced liver injury 40.54 11.91 210 96570 119857 110372662
Infective keratitis 40.27 11.91 11 96769 109 110492410
Photophobia 40.12 11.91 77 96703 25694 110466825
Corneal deposits 39.30 11.91 16 96764 580 110491939
Tendon discomfort 39.17 11.91 16 96764 585 110491934
Sciatica 38.72 11.91 172 96608 92227 110400292
Cardio-respiratory arrest 38.68 11.91 27 96753 115809 110376710
Necrotising scleritis 38.38 11.91 13 96767 278 110492241
Diarrhoea 38.33 11.91 735 96045 1138770 109353749
Corneal flap complication 37.97 11.91 7 96773 6 110492513
Disseminated mycobacterium avium complex infection 37.94 11.91 15 96765 503 110492016
Fibrin 37.78 11.91 8 96772 22 110492497
Hyponatraemia 37.76 11.91 84 96696 217569 110274950
Retinal ischaemia 37.19 11.91 18 96762 989 110491530
Injection site swelling 37.18 11.91 5 96775 61785 110430734
Keratic precipitates 36.91 11.91 15 96765 541 110491978
Bronchitis chronic 36.38 11.91 32 96748 4908 110487611
Foreign body sensation in eyes 36.00 11.91 27 96753 3307 110489212
Vitreal cells 35.63 11.91 11 96769 173 110492346
Corynebacterium infection 35.44 11.91 22 96758 1978 110490541
Anterior chamber inflammation 35.25 11.91 16 96764 759 110491760
Sleep disorder due to general medical condition, hypersomnia type 35.25 11.91 22 96758 1997 110490522
Contraindicated product administered 35.20 11.91 352 96428 247915 110244604
Inappropriate schedule of product administration 34.99 11.91 79 96701 203558 110288961
X-ray abnormal 34.71 11.91 92 96688 38025 110454494
NPM1 gene mutation 34.14 11.91 10 96770 130 110492389
Neutropenia 33.75 11.91 191 96589 374429 110118090
Product use issue 33.73 11.91 419 96361 311276 110181243
Corneal transplant 33.63 11.91 13 96767 410 110492109
Immune reconstitution inflammatory syndrome associated tuberculosis 33.46 11.91 17 96763 1037 110491482
Eczema 33.04 11.91 11 96769 72282 110420237
Neoplasm progression 32.90 11.91 8 96772 64587 110427932
Urethritis mycoplasmal 32.61 11.91 7 96773 21 110492498
Memory impairment 32.56 11.91 78 96702 196866 110295653
Deafness 32.39 11.91 72 96708 26637 110465882
Pulmonary fibrosis 32.08 11.91 175 96605 101867 110390652
Mycobacterium avium complex infection 31.65 11.91 32 96748 5845 110486674
Hypoglycaemia 31.52 11.91 33 96747 116071 110376448
Cardiogenic shock 31.45 11.91 6 96774 57332 110435187
Hyperhidrosis 31.27 11.91 275 96505 187023 110305496
Peripheral venous disease 31.13 11.91 151 96629 83966 110408553
Febrile neutropenia 31.03 11.91 157 96623 316610 110175909
Retinal detachment 30.69 11.91 43 96737 11057 110481462
Multiple sclerosis relapse 30.39 11.91 4 96776 50236 110442283
Sputum discoloured 30.21 11.91 72 96708 27873 110464646
Lymphoedema 30.18 11.91 50 96730 14879 110477640
Neck pain 30.17 11.91 38 96742 123092 110369427
Haematochezia 30.07 11.91 34 96746 115490 110377029
Conjunctival oedema 29.83 11.91 18 96762 1538 110490981
Hepatic steatosis 29.49 11.91 102 96678 48729 110443790
Atypical mycobacterial infection 29.32 11.91 22 96758 2696 110489823
Vaccination site haemorrhage 29.30 11.91 7 96773 38 110492481
Coronary artery disease 29.29 11.91 13 96767 71677 110420842
Hypothyroidism 29.27 11.91 134 96646 72765 110419754
Atrial fibrillation 29.17 11.91 103 96677 229539 110262980
Colitis 29.01 11.91 28 96752 102295 110390224
Seizure 28.91 11.91 98 96682 221087 110271432
Injection site pruritus 28.90 11.91 5 96775 51253 110441266
Transient ischaemic attack 28.78 11.91 10 96770 63972 110428547
Hypotony of eye 28.77 11.91 12 96768 463 110492056
Swollen joint count increased 28.71 11.91 147 96633 83514 110409005
Factor V deficiency 28.53 11.91 8 96772 88 110492431
Lip dry 28.40 11.91 167 96613 99916 110392603
Syncope 28.38 11.91 87 96693 202449 110290070
Mycobacterium fortuitum infection 28.18 11.91 12 96768 488 110492031
Taste disorder 28.09 11.91 11 96769 65376 110427143
Anxiety 28.08 11.91 441 96339 344637 110147882
Flat anterior chamber of eye 28.02 11.91 9 96771 162 110492357
Sleep disorder due to general medical condition, insomnia type 27.89 11.91 173 96607 105470 110387049
Cellulitis 27.76 11.91 42 96738 125974 110366545
Dysphagia 27.70 11.91 58 96722 153542 110338977
Retinal vasculitis 27.64 11.91 19 96761 2030 110490489
Anaphylactic reaction 27.60 11.91 183 96597 114117 110378402
Allergic fungal rhinosinusitis 27.30 11.91 7 96773 53 110492466
Orthostatic hypotension 27.09 11.91 12 96768 66237 110426282
Chest injury 26.96 11.91 23 96757 3386 110489133
Lactic acidosis 26.78 11.91 25 96755 92786 110399733
Weight decreased 26.76 11.91 271 96509 467786 110024733
Liver function test increased 26.57 11.91 23 96757 88525 110403994
Balance disorder 26.50 11.91 38 96742 116522 110375997
Facet joint syndrome 26.47 11.91 160 96620 96668 110395851
Respiratory arrest 26.41 11.91 9 96771 58290 110434229
Corneal striae 26.33 11.91 7 96773 62 110492457
Nail disorder 26.15 11.91 9 96771 57926 110434593
Lethargy 26.08 11.91 26 96754 93550 110398969
Acute myocardial infarction 26.08 11.91 21 96759 83756 110408763
Chimerism 26.00 11.91 10 96770 311 110492208
Keratitis 25.87 11.91 27 96753 5117 110487402
Accidental exposure to product 25.85 11.91 6 96774 50002 110442517
Diastasis recti abdominis 25.85 11.91 7 96773 67 110492452
Mycobacterium abscessus infection 25.85 11.91 17 96763 1689 110490830
Rhabdomyolysis 25.69 11.91 41 96739 120360 110372159
Eye infection fungal 25.61 11.91 12 96768 613 110491906
Haematemesis 25.30 11.91 10 96770 59098 110433421
Influenza like illness 25.29 11.91 24 96756 88388 110404131
Pupillary disorder 25.14 11.91 12 96768 639 110491880
Painful respiration 25.08 11.91 23 96757 3724 110488795
Deep vein thrombosis 25.08 11.91 53 96727 139834 110352685
Iris adhesions 25.00 11.91 12 96768 647 110491872
Cataract 24.77 11.91 136 96644 79349 110413170
Musculoskeletal pain 24.74 11.91 257 96523 182766 110309753
Obesity 24.72 11.91 177 96603 113174 110379345
Herpes zoster meningoencephalitis 24.71 11.91 14 96766 1064 110491455
Onychomadesis 24.58 11.91 5 96775 45658 110446861
Incorrect dose administered 24.35 11.91 33 96747 103608 110388911
Metabolic acidosis 24.21 11.91 31 96749 99713 110392806
Road traffic accident 24.18 11.91 169 96611 107229 110385290
Renal failure 24.10 11.91 109 96671 226465 110266054
White blood cell count decreased 24.02 11.91 111 96669 229279 110263240
General physical health deterioration 24.00 11.91 247 96533 425048 110067471
Gastrointestinal haemorrhage 23.98 11.91 70 96710 165448 110327071
Asthenia 23.53 11.91 443 96337 688556 109803963
Coma 23.43 11.91 42 96738 117827 110374692
Cardiac arrest 23.19 11.91 91 96689 196662 110295857
Melaena 22.99 11.91 16 96764 68741 110423778
Ulcer 22.63 11.91 5 96775 43111 110449408
General symptom 22.59 11.91 33 96747 8813 110483706
Aortic aneurysm 22.52 11.91 35 96745 9869 110482650
Hallucination 22.47 11.91 159 96621 101273 110391246
C-reactive protein abnormal 22.47 11.91 192 96588 129503 110363016
Cystoid macular oedema 22.37 11.91 19 96761 2781 110489738
Product quality issue 22.09 11.91 21 96759 77278 110415241
Amaurosis 22.07 11.91 15 96765 1574 110490945
Aqueous humour leakage 21.93 11.91 4 96776 3 110492516
Blepharitis allergic 21.93 11.91 4 96776 3 110492516
Bronchial ulceration 21.93 11.91 4 96776 3 110492516
Corneal scar 21.93 11.91 9 96771 333 110492186
Cerebral haemorrhage 21.88 11.91 15 96765 64953 110427566
Subcutaneous drug absorption impaired 21.67 11.91 30 96750 7629 110484890
Blood immunoglobulin M increased 21.66 11.91 15 96765 1622 110490897
Blood immunoglobulin A decreased 21.63 11.91 17 96763 2231 110490288
Cognitive disorder 21.45 11.91 27 96753 87484 110405035
Blindness unilateral 21.45 11.91 34 96746 9752 110482767
Nephrolithiasis 21.36 11.91 16 96764 66196 110426323
Skin reaction 21.28 11.91 53 96727 21091 110471428
Tachycardia 21.25 11.91 114 96666 226531 110265988
Mycobacterial peritonitis 21.23 11.91 8 96772 235 110492284
Onychomycosis 21.20 11.91 4 96776 38527 110453992
Eye abscess 21.11 11.91 9 96771 367 110492152
Metastases to liver 20.97 11.91 3 96777 35383 110457136
Optic neuropathy 20.88 11.91 23 96757 4635 110487884
Visual impairment 20.71 11.91 194 96586 134234 110358285
Blood creatinine increased 20.66 11.91 86 96694 182803 110309716
Mediastinal effusion 20.63 11.91 6 96774 76 110492443
Tuberculosis 20.53 11.91 47 96733 17727 110474792
Prostate cancer 20.51 11.91 4 96776 37637 110454882
Illness 20.51 11.91 25 96755 82146 110410373
Epistaxis 20.48 11.91 53 96727 130319 110362200
Therapeutic response decreased 20.46 11.91 33 96747 96466 110396053
Maternal exposure timing unspecified 20.45 11.91 52 96728 20961 110471558
Psoas abscess 20.43 11.91 14 96766 1488 110491031
Blood bilirubin increased 20.42 11.91 125 96655 75847 110416672
Choroidal detachment 20.37 11.91 11 96769 761 110491758
Back injury 20.32 11.91 8 96772 47391 110445128
Swollen tongue 20.24 11.91 14 96766 60348 110432171
Detachment of retinal pigment epithelium 20.24 11.91 12 96768 993 110491526
Adrenal insufficiency 20.17 11.91 6 96774 42384 110450135
Scleral thinning 20.14 11.91 6 96774 83 110492436
Convulsions local 20.14 11.91 6 96774 83 110492436
Mycobacterial infection 20.12 11.91 22 96758 4395 110488124
Pseudoendophthalmitis 20.08 11.91 6 96774 84 110492435
Oral mucosal hypertrophy 19.97 11.91 5 96775 34 110492485
Injection site bruising 19.86 11.91 10 96770 51253 110441266
Scleromalacia 19.82 11.91 6 96774 88 110492431
Culture negative 19.78 11.91 4 96776 8 110492511
Unevaluable event 19.51 11.91 14 96766 59213 110433306
Hypoxia 19.50 11.91 186 96594 129329 110363190
Surgery 19.36 11.91 6 96774 41277 110451242
Ischaemic stroke 19.35 11.91 6 96774 41257 110451262
Thalamic infarction 19.34 11.91 13 96767 1339 110491180
Thrombocytopenia 19.32 11.91 420 96360 348465 110144054
Finger deformity 19.16 11.91 3 96777 33089 110459430
Muscle injury 19.16 11.91 198 96582 140609 110351910
Acoustic neuroma 19.15 11.91 8 96772 310 110492209
Trichoglossia 19.02 11.91 11 96769 869 110491650
Vitreous floaters 19.01 11.91 31 96749 9103 110483416
Night sweats 18.99 11.91 190 96590 133793 110358726
Procedural pain 18.92 11.91 4 96776 35561 110456958
Anterior chamber pigmentation 18.89 11.91 4 96776 11 110492508
Encephalopathy 18.85 11.91 26 96754 81029 110411490
Peripheral nerve injury 18.77 11.91 12 96768 1136 110491383
Urinary retention 18.69 11.91 20 96760 69663 110422856
Bronchiolitis obliterans syndrome 18.68 11.91 10 96770 680 110491839
Retinal perivascular sheathing 18.63 11.91 6 96774 109 110492410
Hip fracture 18.61 11.91 4 96776 35147 110457372
Agranulocytosis 18.58 11.91 16 96764 61744 110430775
Corneal neovascularisation 18.50 11.91 7 96773 208 110492311
Donor leukocyte infusion 18.45 11.91 5 96775 48 110492471
Anterior chamber flare 18.41 11.91 7 96773 211 110492308
Hypercalcaemia 18.23 11.91 9 96771 46648 110445871
Eye infection staphylococcal 18.22 11.91 7 96773 217 110492302
Vitreous haze 18.18 11.91 6 96774 118 110492401
Stenotrophomonas infection 18.18 11.91 24 96756 5834 110486685
Gonioscopy abnormal 18.13 11.91 3 96777 0 110492519
Venom poisoning 18.13 11.91 3 96777 0 110492519
Cataract operation 18.10 11.91 24 96756 5859 110486660
Tuberculosis of central nervous system 18.04 11.91 9 96771 528 110491991
Papilloma 17.98 11.91 9 96771 532 110491987
Pneumonia aspiration 17.96 11.91 27 96753 81206 110411313
Dyspepsia 17.93 11.91 96 96684 190869 110301650
No adverse event 17.87 11.91 23 96757 73816 110418703
Deafness neurosensory 17.83 11.91 31 96749 9588 110482931
FEV1/FVC ratio abnormal 17.75 11.91 5 96775 56 110492463
Angina pectoris 17.71 11.91 17 96763 62278 110430241
Loss of consciousness 17.71 11.91 100 96680 196206 110296313
Blood pressure increased 17.63 11.91 143 96637 258230 110234289
Palmar-plantar erythrodysaesthesia syndrome 17.46 11.91 7 96773 41018 110451501
Gastrointestinal disorder 17.37 11.91 303 96477 241649 110250870
Drug ineffective for unapproved indication 17.16 11.91 151 96629 102687 110389832
Metamorphopsia 17.13 11.91 13 96767 1620 110490899
Mycobacterium chelonae infection 17.10 11.91 17 96763 3043 110489476
Alopecia 17 11.91 221 96559 364532 110127987
Haematospermia 16.93 11.91 7 96773 264 110492255
Abdominal pain 16.83 11.91 332 96448 512657 109979862
Multiple fractures 16.82 11.91 29 96751 8911 110483608
Pruritus allergic 16.75 11.91 13 96767 1675 110490844
Muscular weakness 16.73 11.91 138 96642 248330 110244189
Skin injury 16.71 11.91 19 96761 3963 110488556
Corneal thinning 16.69 11.91 7 96773 274 110492245
Headache 16.66 11.91 618 96162 881759 109610760
Pollakiuria 16.56 11.91 9 96771 44186 110448333
Tender joint count 16.55 11.91 12 96768 1395 110491124
Ocular hypertension 16.55 11.91 15 96765 2393 110490126
Nosocomial infection 16.46 11.91 17 96763 3182 110489337
Hypokalaemia 16.42 11.91 93 96687 182355 110310164
Blood pressure fluctuation 16.42 11.91 25 96755 74799 110417720
Glaucoma 16.27 11.91 50 96730 22467 110470052
Caffeine allergy 16.27 11.91 4 96776 25 110492494
Lung neoplasm 16.26 11.91 27 96753 8049 110484470
Drug dependence 16.25 11.91 12 96768 50008 110442511
Respiratory moniliasis 16.19 11.91 8 96772 460 110492059
Mental status changes 16.16 11.91 26 96754 76096 110416423
Type IV hypersensitivity reaction 16.13 11.91 23 96757 6010 110486509
Accidental overdose 16.12 11.91 13 96767 51821 110440698
Polyneuropathy 16.08 11.91 63 96717 31949 110460570
Joint swelling 16.04 11.91 504 96276 442341 110050178
Vitreous haemorrhage 16.02 11.91 20 96760 4600 110487919
Retinal injury 16.01 11.91 8 96772 471 110492048
Lower respiratory tract infection 15.89 11.91 300 96480 242806 110249713
Subdural haematoma 15.88 11.91 6 96774 36448 110456071
Serotonin syndrome 15.84 11.91 17 96763 59136 110433383
Gastroenteritis staphylococcal 15.83 11.91 7 96773 312 110492207
Pulmonary hypertension 15.78 11.91 15 96765 55205 110437314
Withdrawal syndrome 15.76 11.91 4 96776 31376 110461143
Implant site hypersensitivity 15.75 11.91 4 96776 29 110492490
Eye oedema 15.75 11.91 15 96765 2547 110489972
Inappropriate antidiuretic hormone secretion 15.73 11.91 5 96775 33846 110458673
Respiratory rate increased 15.68 11.91 53 96727 25030 110467489
Tendon disorder 15.63 11.91 27 96753 8310 110484209
Incoherent 15.58 11.91 27 96753 8331 110484188
Biopsy colon abnormal 15.52 11.91 5 96775 91 110492428
Gait disturbance 15.51 11.91 162 96618 278046 110214473
Hyperglycaemia 15.45 11.91 32 96748 85058 110407461
Urinary incontinence 15.34 11.91 12 96768 48575 110443944
Haematuria 15.25 11.91 31 96749 82974 110409545
Masticatory pain 15.19 11.91 4 96776 34 110492485
Mucosal inflammation 15.16 11.91 39 96741 96102 110396417
Drug interaction 15.13 11.91 328 96452 499855 109992664
Diabetic ketoacidosis 15.13 11.91 9 96771 42049 110450470
Hypoacusis 15.11 11.91 66 96714 35125 110457394
Gastric ulcer 15.08 11.91 8 96772 39819 110452700
Nocardiosis 15.03 11.91 25 96755 7461 110485058
Cholelithiasis 14.98 11.91 101 96679 63321 110429198
Oral pain 14.97 11.91 7 96773 37437 110455082
Toxic optic neuropathy 14.89 11.91 11 96769 1317 110491202
Haemostasis 14.89 11.91 8 96772 548 110491971
Phosphorus metabolism disorder 14.84 11.91 3 96777 6 110492513
Porphyria acute 14.80 11.91 43 96737 18737 110473782
Idiopathic orbital inflammation 14.75 11.91 7 96773 368 110492151
Corneal defect 14.70 11.91 4 96776 39 110492480
Eye discharge 14.68 11.91 27 96753 8727 110483792
Basal cell carcinoma 14.53 11.91 11 96769 45259 110447260
Device issue 14.53 11.91 6 96774 34529 110457990
Pain in jaw 14.51 11.91 14 96766 51163 110441356
Blepharospasm 14.43 11.91 16 96764 54835 110437684
Tooth disorder 14.37 11.91 4 96776 29505 110463014
Hyphaema 14.31 11.91 10 96770 1097 110491422
Pulmonary oedema 14.26 11.91 43 96737 100616 110391903
Scleral disorder 14.25 11.91 6 96774 237 110492282
Interstitial lung disease 14.24 11.91 68 96712 139266 110353253
Anterior chamber fibrin 14.09 11.91 6 96774 244 110492275
Nasal crusting 14.08 11.91 9 96771 852 110491667
Poisoning 14.07 11.91 4 96776 29101 110463418
Increased viscosity of bronchial secretion 14.00 11.91 8 96772 618 110491901
Haemorrhage intracranial 13.97 11.91 4 96776 28965 110463554
Upper respiratory tract irritation 13.95 11.91 6 96774 250 110492269
Pulmonary venous thrombosis 13.91 11.91 6 96774 252 110492267
Ocular discomfort 13.91 11.91 26 96754 8507 110484012
Extrapyramidal disorder 13.89 11.91 4 96776 28863 110463656
Tendon rupture 13.87 11.91 35 96745 14043 110478476
Eye infection bacterial 13.84 11.91 7 96773 423 110492096
Cholestasis 13.73 11.91 22 96758 64496 110428023
Metastases to neck 13.73 11.91 4 96776 51 110492468
Pregnancy 13.71 11.91 84 96696 50983 110441536
Appendicitis 13.60 11.91 4 96776 28460 110464059
AIDS related complication 13.59 11.91 4 96776 53 110492466
Renal disorder 13.50 11.91 14 96766 49465 110443054
Hyperalbuminaemia 13.32 11.91 4 96776 57 110492462
Neurilemmoma benign 13.31 11.91 3 96777 12 110492507
Pneumonia haemophilus 13.21 11.91 14 96766 2701 110489818
Cutis laxa 13.17 11.91 5 96775 150 110492369
Pulmonary arterial hypertension 13.16 11.91 6 96774 32562 110459957
Rectal haemorrhage 13.13 11.91 57 96723 119776 110372743
Corneal erosion 13.13 11.91 7 96773 472 110492047
Sitting disability 13.13 11.91 7 96773 472 110492047
Enzyme activity increased 13.12 11.91 3 96777 13 110492506
Arthropathy 13.10 11.91 175 96605 287347 110205172
Eyelid oedema 13.05 11.91 36 96744 15226 110477293
Diabetes mellitus 13 11.91 44 96736 99337 110393182
Nausea 12.99 11.91 919 95861 1234771 109257748
Macular fibrosis 12.92 11.91 8 96772 716 110491803
Multiple use of single-use product 12.90 11.91 10 96770 1286 110491233
Acute myeloid leukaemia recurrent 12.88 11.91 19 96761 5120 110487399
HIV infection 12.85 11.91 10 96770 1293 110491226
Full blood count decreased 12.83 11.91 6 96774 32093 110460426
Abortion spontaneous 12.82 11.91 7 96773 34275 110458244
Diabetes mellitus inadequate control 12.81 11.91 5 96775 29770 110462749
Aggression 12.78 11.91 20 96760 59190 110433329
Pleural effusion 12.75 11.91 97 96683 177612 110314907
Adverse reaction 12.68 11.91 5 96775 29589 110462930
Loss of personal independence in daily activities 12.67 11.91 193 96587 149827 110342692
Visual acuity reduced transiently 12.67 11.91 6 96774 314 110492205
Allergic cough 12.57 11.91 9 96771 1026 110491493
Poor venous access 12.56 11.91 3 96777 24519 110468000
Retinal artery occlusion 12.56 11.91 17 96763 4232 110488287
Bronchial irritation 12.56 11.91 4 96776 70 110492449
Forced vital capacity abnormal 12.45 11.91 4 96776 72 110492447
Intestinal obstruction 12.45 11.91 17 96763 53210 110439309
Blood immunoglobulin G increased 12.44 11.91 16 96764 3792 110488727
Hypervolaemia 12.39 11.91 15 96765 49445 110443074
Complications of transplant surgery 12.38 11.91 8 96772 771 110491748
Arthralgia 12.36 11.91 557 96223 779075 109713444
Morganella infection 12.35 11.91 10 96770 1369 110491150
Metastases to thyroid 12.35 11.91 4 96776 74 110492445
Metastases to bone 12.33 11.91 6 96774 31366 110461153
Nerve block 12.29 11.91 8 96772 781 110491738
Dysmetria 12.23 11.91 10 96770 1389 110491130
Suspected counterfeit product 12.13 11.91 8 96772 798 110491721
Bronchitis 12.12 11.91 199 96581 156833 110335686
Choroidal neovascularisation 12.12 11.91 7 96773 552 110491967
Erythema of eyelid 12.09 11.91 16 96764 3899 110488620
Injury 12.01 11.91 220 96560 177045 110315474
Long QT syndrome 11.99 11.91 22 96758 7096 110485423
Atypical mycobacterium test positive 11.92 11.91 4 96776 83 110492436
Dry skin 11.92 11.91 51 96729 107602 110384917

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
ATC J01MA14 ANTIINFECTIVES FOR SYSTEMIC USE
ANTIBACTERIALS FOR SYSTEMIC USE
QUINOLONE ANTIBACTERIALS
Fluoroquinolones
ATC S01AE07 SENSORY ORGANS
OPHTHALMOLOGICALS
ANTIINFECTIVES
Fluoroquinolones
FDA CS M0372253 Fluoroquinolones
MeSH PA D000890 Anti-Infective Agents
MeSH PA D000900 Anti-Bacterial Agents
MeSH PA D000970 Antineoplastic Agents
MeSH PA D004791 Enzyme Inhibitors
MeSH PA D059005 Topoisomerase II Inhibitors
CHEBI has role CHEBI:33281 antimicrobial agent
CHEBI has role CHEBI:33282 antibacterial agent
CHEBI has role CHEBI:35441 antiinfective agent
CHEBI has role CHEBI:35610 antineoplastic agent
CHEBI has role CHEBI:36047 antibacterial drug
CHEBI has role CHEBI:49201 anti-ulcer drug
CHEBI has role CHEBI:66981 ophthalmology drug
CHEBI has role CHEBI:67079 anti-inflammatory agent
FDA EPC N0000193223 Fluoroquinolone Antibacterial
CHEBI has role CHEBI:22587 antiviral agent
CHEBI has role CHEBI:33231 antitubercular agent
CHEBI has role CHEBI:35476 antipsychotic agent
CHEBI has role CHEBI:35480 analgesic
CHEBI has role CHEBI:35526 hypoglycemic agent
CHEBI has role CHEBI:35554 cardiovascular drug
CHEBI has role CHEBI:35620 vasodilator agent
CHEBI has role CHEBI:35623 anticonvulsant
CHEBI has role CHEBI:35674 antihypertensive agent
CHEBI has role CHEBI:35842 antirheumatic drug
CHEBI has role CHEBI:38068 antimalarial
CHEBI has role CHEBI:48407 antiparkinson drug
CHEBI has role CHEBI:50503 laxative
CHEBI has role CHEBI:50514 vasoconstrictor agent
CHEBI has role CHEBI:50919 antiemetic
CHEBI has role CHEBI:64946 anti-HIV agent
CHEBI has role CHEBI:65023 anti-asthmatic agent
CHEBI has role CHEBI:74518 anti-obesity agent
CHEBI has role CHEBI:75835 anti-anaemic agent
CHEBI has role CHEBI:76916 hyperglycemic agent

Related Drugs by ATC class:

J01MA Fluoroquinolones 22 drugs
ciprofloxacindelafloxacinenoxacinfleroxacingarenoxacingatifloxacingemifloxacingrepafloxacinlascufloxacinlevofloxacinlomefloxacinnorfloxacin show all 22 →
S01AE Fluoroquinolones 8 drugs
besifloxacinciprofloxacingatifloxacinlevofloxacinlomefloxacinnorfloxacinofloxacintosufloxacin

Drug Use | Suggest Off label Use Form| |View source of the data|

DiseaseRelationSNOMED_IDDOID
Septicemic plague indication 9012003 DOID:3481
Infection of skin AND/OR subcutaneous tissue indication 19824006
Staphylococcal pneumonia indication 22754005
Pneumonia due to Streptococcus indication 34020007
Pneumonic plague indication 38976008 DOID:10398
Pneumonia due to Mycoplasma pneumoniae indication 46970008
Peritonitis indication 48661000
Bacterial pneumonia indication 53084003 DOID:874
Pneumonia due to Klebsiella pneumoniae indication 64479007
Haemophilus influenzae pneumonia indication 70036007
Rhinoscleroma indication 72409005 DOID:11336
Abdominal abscess indication 75100008
Acute bacterial sinusitis indication 75498004
Infectious disease of abdomen indication 128070006
Bacterial conjunctivitis indication 128350005 DOID:9700
Infection due to Enterobacteriaceae indication 128945009
Bacterial infection due to Klebsiella pneumoniae indication 186435004
Pneumococcal pneumonia indication 233607000
Chlamydial pneumonia indication 233609002
Streptococcus pyogenes infection indication 302809008
Infection due to Staphylococcus aureus indication 406602003
Acute exacerbation of chronic bronchitis indication 425748003
Complicated Skin and Skin Structure E. Coli Infection indication
Complicated Skin and Skin Structure Infection indication
Haemophilus Influenzae Chronic Bronchitis indication
Complicated Skin and Skin Structure Staphylococcus Aureus Infection indication
Haemophilus Parainfluenzae Chronic Bronchitis indication
Streptococcus Pneumoniae Chronic Bronchitis indication
Moraxella Catarrhalis Pneumonia indication
Staphylococcus Chronic Bronchitis indication
Klebsiella Pneumoniae Chronic Bronchitis indication
Moraxella Catarrhalis Chronic Bronchitis indication
Acute tuberculosis off-label use 25629007
Pulmonary tuberculosis off-label use 154283005 DOID:2957
Cirrhosis of liver contraindication 19943007 DOID:5082
Torsades de pointes contraindication 31722008
Transplantation of heart contraindication 32413006
Tendinitis contraindication 34840004 DOID:971
Hypokalemia contraindication 43339004
Conduction disorder of the heart contraindication 44808001
Bradycardia contraindication 48867003
Transplant of kidney contraindication 70536003
Epilepsy contraindication 84757009 DOID:1826
Transplant of lung contraindication 88039007
Myasthenia gravis contraindication 91637004 DOID:437
Prolonged QT interval contraindication 111975006
Liver function tests abnormal contraindication 166603001
Drug-induced hepatitis contraindication 235876009
Peripheral nerve disease contraindication 302226006
Pseudomembranous enterocolitis contraindication 397683000
Myocardial ischemia contraindication 414795007 DOID:3393
Traumatic rupture of tendon contraindication 415749005
Congenital long QT syndrome contraindication 442917000
Severe Cerebral Arteriosclerosis contraindication




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 6.23 acidic
pKa2 8.54 Basic
pKa3 2.92 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])		Mechanism
action		Bioact sourceMoA source
Topoisomerase IV Enzyme INHIBITOR CHEMBL CHEMBL
DNA gyrase Enzyme INHIBITOR IC50 6.52 CHEMBL CHEMBL
DNA topoisomerase 4 subunit A Enzyme IC50 6.10 CHEMBL
DNA gyrase subunit A Enzyme IC50 5.04 CHEMBL

External reference:

IDSource
D00874 KEGG_DRUG
186826-86-8 SECONDARY_CAS_RN
4021185 VANDF
4021186 VANDF
C0536495 UMLSCUI
CHEBI:63611 CHEBI
MFX PDB_CHEM_ID
CHEMBL32 ChEMBL_ID
CHEMBL1200735 ChEMBL_ID
D000077266 MESH_DESCRIPTOR_UI
DB00218 DRUGBANK_ID
152946 PUBCHEM_CID
10915 IUPHAR_LIGAND_ID
7659 INN_ID
U188XYD42P UNII
1047505 RXNORM
178916 MMSL
213098 MMSL
260370 MMSL
31558 MMSL
35332 MMSL
359581 MMSL
359583 MMSL
40847 MMSL
8580 MMSL
d04500 MMSL
007927 NDDF
007928 NDDF
116347002 SNOMEDCT_US
371296007 SNOMEDCT_US
412439003 SNOMEDCT_US

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
VIGAMOX HUMAN PRESCRIPTION DRUG LABEL 1 0078-0939 SOLUTION/ DROPS 5 mg OPHTHALMIC NDA 25 sections
Moxifloxacin Ophthalmic Solution HUMAN PRESCRIPTION DRUG LABEL 1 0781-7135 SOLUTION/ DROPS 5 mg OPHTHALMIC NDA authorized generic 25 sections
Moxifloxacin Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 0832-1410 SOLUTION 5 mg OPHTHALMIC ANDA 26 sections
MOXIFLOXACIN HYDROCHLORIDE HUMAN PRESCRIPTION DRUG LABEL 1 0904-7407 TABLET, FILM COATED 400 mg ORAL ANDA 29 sections
Avelox ABC Pack HUMAN PRESCRIPTION DRUG LABEL 1 16590-881 TABLET, FILM COATED 400 mg ORAL NDA 17 sections
MOXIFLOXACIN Human Prescription Drug Label 1 16714-643 SOLUTION/ DROPS 5 mg OPHTHALMIC ANDA 23 sections
Moxifloxacin HUMAN PRESCRIPTION DRUG LABEL 1 17478-519 SOLUTION/ DROPS 5 mg OPHTHALMIC ANDA 25 sections
VIGAMOX HUMAN PRESCRIPTION DRUG LABEL 1 21695-968 SOLUTION 5 mg OPHTHALMIC NDA 20 sections
Moxifloxacin HUMAN PRESCRIPTION DRUG LABEL 1 31722-845 TABLET, FILM COATED 400 mg ORAL ANDA 28 sections
Moxifloxacin HUMAN PRESCRIPTION DRUG LABEL 1 31722-845 TABLET, FILM COATED 400 mg ORAL ANDA 28 sections
Moxifloxacin Human Prescription Drug Label 1 33342-322 TABLET, FILM COATED 400 mg ORAL ANDA 29 sections
Moxifloxacin Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 40032-034 TABLET 400 mg ORAL ANDA 28 sections
Moxifloxacin ophthalmic solution Human Prescription Drug Label 1 46708-505 SOLUTION/ DROPS 5 mg OPHTHALMIC ANDA 23 sections
Moxifloxacin ophthalmic solution Human Prescription Drug Label 1 50090-4781 SOLUTION/ DROPS 5 mg OPHTHALMIC ANDA 23 sections
Moxifloxacin HUMAN PRESCRIPTION DRUG LABEL 1 50090-5279 SOLUTION/ DROPS 5 mg OPHTHALMIC ANDA 24 sections
Moxifloxacin Ophthalmic HUMAN PRESCRIPTION DRUG LABEL 1 50090-6248 SOLUTION/ DROPS 5 mg OPHTHALMIC ANDA 23 sections
Moxifloxacin HUMAN PRESCRIPTION DRUG LABEL 1 50090-6357 SOLUTION/ DROPS 5 mg OPHTHALMIC ANDA 24 sections
Moxifloxacin Hydrochloride Human Prescription Drug Label 1 50090-6609 TABLET, FILM COATED 400 mg ORAL ANDA 29 sections
MOXIFLOXACIN HYDROCHLORIDE Human Prescription Drug Label 1 50090-7244 TABLET, FILM COATED 400 mg ORAL ANDA 29 sections
Moxifloxacin Hydrochloride Human Prescription Drug Label 1 50090-7665 TABLET, FILM COATED 400 mg ORAL ANDA 28 sections
Moxifloxacin Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 50268-576 TABLET, FILM COATED 400 mg ORAL ANDA 30 sections
Moxifloxacin Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 50268-576 TABLET, FILM COATED 400 mg ORAL ANDA 30 sections
Moxifloxacin ophthalmic solution Human Prescription Drug Label 1 53002-2626 SOLUTION/ DROPS 5 mg OPHTHALMIC ANDA 23 sections
Moxifloxacin HUMAN PRESCRIPTION DRUG LABEL 1 53002-2723 TABLET, FILM COATED 400 mg ORAL ANDA 30 sections
Avelox HUMAN PRESCRIPTION DRUG LABEL 1 54868-4367 TABLET, FILM COATED 400 mg ORAL NDA 30 sections
VIGAMOX HUMAN PRESCRIPTION DRUG LABEL 1 54868-4798 SOLUTION 5 mg OPHTHALMIC NDA 24 sections
Moxifloxacin HUMAN PRESCRIPTION DRUG LABEL 1 55111-112 TABLET, FILM COATED 400 mg ORAL ANDA 30 sections
Moxifloxacin Hydrochloride Human Prescription Drug Label 1 57237-156 TABLET, FILM COATED 400 mg ORAL ANDA 29 sections
Moxifloxacin Hydrochloride Human Prescription Drug Label 1 57237-156 TABLET, FILM COATED 400 mg ORAL ANDA 29 sections
Moxifloxacin ophthalmic solution Human Prescription Drug Label 1 62332-505 SOLUTION/ DROPS 5 mg OPHTHALMIC ANDA 23 sections