loperamide 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
1599 53179-11-6

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • loperamide
  • loperamide hydrochloride
  • imodium
  • loperamide HCl
One of the long-acting synthetic ANTIDIARRHEALS; it is not significantly absorbed from the gut, and has no effect on the adrenergic system or central nervous system, but may antagonize histamine and interfere with acetylcholine release locally.
  • Molecular weight: 477.05
  • Formula: C29H33ClN2O2
  • CLOGP: 4.66
  • LIPINSKI: 0
  • HAC: 4
  • HDO: 1
  • TPSA: 43.78
  • ALOGS: -5.74
  • ROTB: 7
  • Status: OFP
    • Legend:
    OFP - off patent
    OFM - off market
    ONP - on patent

Drug dosage:

DoseUnitRoute
10 mg O

ADMET properties:

PropertyValueReference
BDDCS (Biopharmaceutical Drug Disposition Classification System) 1 Bocci G, Oprea TI, Benet LZ
S (Water solubility) 0.01 mg/mL Bocci G, Oprea TI, Benet LZ
EoM (Fraction excreted unchanged in urine) 0.50 % Benet LZ, Broccatelli F, Oprea TI
MRTD (Maximum Recommended Therapeutic Daily Dose) 0.48 µM/kg/day Contrera JF, Matthews EJ, Kruhlak NL, Benz RD
BA (Bioavailability) 40 % Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H

Approvals:

DateAgencyCompanyOrphan
Dec. 28, 1976 FDA MCNEIL CONS

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Diarrhoea 1016.61 10.86 2785 89437 712581 62684219
Dehydration 328.32 10.86 756 91466 172598 63224202
Maternal exposure during pregnancy 239.26 10.86 22 92200 220040 63176760
Systemic lupus erythematosus 237.92 10.86 17 92205 208901 63187899
Hand deformity 211.67 10.86 4 92218 159453 63237347
Vomiting 179.18 10.86 1406 90816 558211 62838589
Pneumonia viral 175.26 10.86 121 92101 7801 63388999
Hypomania 174.74 10.86 111 92111 6219 63390581
Colitis 174.18 10.86 278 91944 48250 63348550
Hypokalaemia 172.88 10.86 431 91791 103373 63293427
Nausea 170.33 10.86 1940 90282 852531 62544269
Jaundice cholestatic 169.45 10.86 115 92107 7209 63389591
Contraindicated product administered 165.33 10.86 55 92167 217593 63179207
Glossodynia 163.21 10.86 31 92191 178845 63217955
Pneumonia aspiration 162.98 10.86 225 91997 34315 63362485
Pericarditis 161.16 10.86 7 92215 131572 63265228
Gastrooesophageal reflux disease 156.00 10.86 394 91828 95245 63301555
Drug ineffective 150.51 10.86 898 91324 1043867 62352933
Schizophrenia 148.48 10.86 120 92102 9832 63386968
Arthropathy 143.97 10.86 81 92141 234711 63162089
Torsade de pointes 142.55 10.86 133 92089 13218 63383582
Decreased appetite 141.36 10.86 729 91493 250323 63146477
Abdominal pain 136.42 10.86 809 91413 292647 63104153
Drug intolerance 134.59 10.86 150 92072 308511 63088289
Ventricular tachycardia 133.80 10.86 155 92067 19824 63376976
Wound 129.78 10.86 38 92184 163225 63233575
Hypomagnesaemia 129.32 10.86 183 92039 28554 63368246
Weight decreased 129.23 10.86 764 91458 276034 63120766
Discomfort 122.43 10.86 45 92177 167329 63229471
Soft tissue disorder 118.23 10.86 76 92146 4346 63392454
Coma 117.53 10.86 277 91945 64087 63332713
Electrocardiogram QT prolonged 116.19 10.86 263 91959 59267 63337533
Drug abuse 113.30 10.86 294 91928 72224 63324576
Rheumatoid arthritis 113.21 10.86 121 92101 253698 63143102
Neuropathy peripheral 113.20 10.86 393 91829 113274 63283526
Total lung capacity increased 110.66 10.86 58 92164 2252 63394548
Constipation 110.21 10.86 629 91593 224314 63172486
Helicobacter infection 110.20 10.86 6 92216 92779 63304021
Therapeutic product effect decreased 109.55 10.86 73 92149 193114 63203686
Pain 104.46 10.86 640 91582 739988 62656812
Macular degeneration 102.04 10.86 150 92072 24226 63372574
Oral pain 96.87 10.86 159 92063 28235 63368565
Psoriatic arthropathy 89.79 10.86 13 92209 91507 63305293
Swelling 89.19 10.86 165 92057 275213 63121587
Completed suicide 88.17 10.86 51 92171 145622 63251178
Mucosal inflammation 85.70 10.86 202 92020 46726 63350074
Exposure during pregnancy 85.22 10.86 61 92161 155486 63241314
Gastrointestinal stoma complication 84.40 10.86 45 92177 1810 63394990
Treatment failure 83.15 10.86 100 92122 198943 63197857
Small intestinal obstruction 82.83 10.86 117 92105 18220 63378580
Febrile neutropenia 78.77 10.86 361 91861 118088 63278712
Blood bilirubin increased 78.00 10.86 169 92053 36971 63359829
Drug hypersensitivity 77.18 10.86 215 92007 310472 63086328
Synovitis 72.79 10.86 99 92123 186819 63209981
Intestinal obstruction 71.15 10.86 146 92076 30753 63366047
Vascular device infection 70.76 10.86 69 92153 7243 63389557
Joint swelling 70.57 10.86 242 91980 327424 63069376
Colitis microscopic 68.55 10.86 76 92146 9263 63387537
Frequent bowel movements 68.09 10.86 121 92101 22901 63373899
Knee arthroplasty 65.97 10.86 3 92219 54203 63342597
Somnolence 65.91 10.86 465 91757 178220 63218580
Brain stem glioma 65.73 10.86 20 92202 172 63396628
Cholelithiasis 65.44 10.86 175 92047 43750 63353050
Hypersensitivity 65.18 10.86 213 92009 292472 63104328
Lethargy 64.98 10.86 204 92018 55803 63340997
Impaired healing 64.79 10.86 34 92188 102508 63294292
Arthralgia 64.59 10.86 524 91698 569186 62827614
Neutropenic sepsis 64.29 10.86 98 92124 16340 63380460
Presbyacusis 63.94 10.86 44 92178 2821 63393979
Abdominal discomfort 63.80 10.86 245 91977 320640 63076160
Folliculitis 62.39 10.86 13 92209 70304 63326496
Blood magnesium increased 61.61 10.86 44 92178 2994 63393806
Proctitis 61.57 10.86 56 92166 5385 63391415
Asthma-chronic obstructive pulmonary disease overlap syndrome 61.56 10.86 38 92184 2023 63394777
Segmental diverticular colitis 59.04 10.86 18 92204 156 63396644
Infusion related reaction 58.67 10.86 173 92049 245348 63151452
Pedal pulse abnormal 58.24 10.86 18 92204 164 63396636
Malignant neoplasm progression 58.12 10.86 255 91967 81866 63314934
Blood magnesium decreased 57.83 10.86 83 92139 13115 63383685
Respiration abnormal 57.37 10.86 58 92164 6359 63390441
Pleural thickening 56.73 10.86 41 92181 2842 63393958
Flatulence 56.56 10.86 143 92079 34559 63362241
Calcium ionised decreased 56.39 10.86 20 92202 289 63396511
Pleural fibrosis 56.36 10.86 44 92178 3428 63393372
Type 2 diabetes mellitus 56.27 10.86 12 92210 63856 63332944
Nail dystrophy 55.19 10.86 28 92194 1015 63395785
Chronic sinusitis 55.15 10.86 80 92142 12763 63384037
Musculoskeletal stiffness 55.08 10.86 116 92106 184502 63212298
Deafness neurosensory 55.00 10.86 50 92172 4805 63391995
Hip arthroplasty 53.83 10.86 4 92218 47642 63349158
Psychotic disorder 52.85 10.86 116 92106 25596 63371204
Appetite disorder 52.74 10.86 59 92163 7262 63389538
Red blood cell sedimentation rate increased 51.73 10.86 3 92219 43979 63352821
Anaemia 50.80 10.86 650 91572 292780 63104020
Paraesthesia oral 49.15 10.86 95 92127 19161 63377639
Sinusitis 49.02 10.86 167 92055 226486 63170314
Intentional overdose 48.53 10.86 225 91997 73927 63322873
Heart sounds 47.69 10.86 25 92197 971 63395829
Pneumonia 46.90 10.86 927 91295 455840 62940960
Dyspepsia 45.59 10.86 279 91943 101917 63294883
Prolonged expiration 45.44 10.86 25 92197 1071 63395729
Long QT syndrome 43.62 10.86 37 92185 3242 63393558
Clostridium difficile infection 43.35 10.86 118 92104 29804 63366996
Rectal haemorrhage 43.23 10.86 163 92059 48867 63347933
Alopecia 42.14 10.86 302 91920 337234 63059566
Blood creatinine increased 41.85 10.86 244 91978 87600 63309200
Brugada syndrome 41.48 10.86 17 92205 371 63396429
Injection site erythema 41.27 10.86 36 92186 83138 63313662
Syncope 41.24 10.86 302 91920 117083 63279717
Weight increased 41.06 10.86 217 92005 260575 63136225
Ventricular arrhythmia 40.60 10.86 38 92184 3790 63393010
Pyrexia 40.58 10.86 931 91291 469547 62927253
Blood potassium decreased 39.81 10.86 143 92079 41883 63354917
Dry skin 39.75 10.86 176 92046 56711 63340089
Pneumonitis 39.66 10.86 127 92095 35095 63361705
Ejection fraction decreased 39.54 10.86 95 92127 22237 63374563
Therapeutic response decreased 39.45 10.86 20 92202 61505 63335295
Stoma complication 39.34 10.86 18 92204 517 63396283
Acute kidney injury 38.81 10.86 567 91655 262848 63133952
Device related infection 38.75 10.86 97 92125 23295 63373505
Hepatotoxicity 38.52 10.86 130 92092 36911 63359889
Injection site pain 38.33 10.86 82 92140 129718 63267082
Drug interaction 38.14 10.86 187 92035 228944 63167856
Electrocardiogram QRS complex prolonged 37.97 10.86 45 92177 5893 63390907
Ill-defined disorder 37.49 10.86 38 92184 81717 63315083
Vaginal flatulence 37.47 10.86 34 92188 3259 63393541
Injection site pruritus 36.75 10.86 10 92212 45106 63351694
Disease progression 36.58 10.86 304 91918 122454 63274346
Device expulsion 36.58 10.86 4 92218 34918 63361882
Urinary tract infection 36.38 10.86 563 91659 264121 63132679
Procedural pain 36.32 10.86 90 92132 21479 63375321
Epigastric discomfort 36.31 10.86 47 92175 6733 63390067
Injection site reaction 36.09 10.86 20 92202 58504 63338296
Feeding intolerance 35.85 10.86 19 92203 755 63396045
Gallbladder polyp 35.55 10.86 19 92203 768 63396032
Mobility decreased 35.39 10.86 77 92145 121082 63275718
Intentional self-injury 33.97 10.86 98 92124 25589 63371211
Rash 33.94 10.86 592 91630 560279 62836521
Product use issue 33.86 10.86 185 92037 220335 63176465
Hypophosphataemia 33.72 10.86 60 92162 11366 63385434
Cardiac arrest 33.60 10.86 240 91982 92305 63304495
Product use in unapproved indication 33.47 10.86 140 92082 178940 63217860
Vaginal discharge 33.40 10.86 53 92169 9145 63387655
Rhinorrhoea 33.10 10.86 185 92037 65392 63331408
Herpes zoster 32.98 10.86 219 92003 82243 63314557
Irritable bowel syndrome 32.72 10.86 43 92179 82369 63314431
Adverse event 32.61 10.86 30 92192 67529 63329271
Sepsis 32.56 10.86 353 91869 152770 63244030
Enterocolitis 32.37 10.86 48 92174 7810 63388990
Gastroenteritis radiation 31.97 10.86 15 92207 457 63396343
Psoriasis 31.90 10.86 48 92174 86909 63309891
Arteriovenous fistula occlusion 31.86 10.86 14 92208 365 63396435
Liver function test abnormal 31.37 10.86 146 92076 48035 63348765
Urticaria 31.37 10.86 129 92093 165673 63231127
Anal abscess 31.11 10.86 36 92186 4596 63392204
Pouchitis 30.95 10.86 15 92207 492 63396308
Blue toe syndrome 30.90 10.86 14 92208 393 63396407
Accidental overdose 30.89 10.86 89 92133 23220 63373580
Pulmonary embolism 30.62 10.86 281 91941 116403 63280397
Premature delivery 30.40 10.86 4 92218 30277 63366523
Unresponsive to stimuli 30.29 10.86 113 92109 33703 63363097
Anal incontinence 29.91 10.86 63 92159 13513 63383287
Gastrointestinal stoma output increased 29.79 10.86 13 92209 333 63396467
Neutropenia 29.53 10.86 386 91836 174619 63222181
Nasal polyps 29.47 10.86 40 92182 5999 63390801
Multiple sclerosis relapse 29.27 10.86 17 92205 48461 63348339
Conduction disorder 29.18 10.86 21 92201 1446 63395354
Leukopenia 28.96 10.86 202 92020 77088 63319712
Dermatitis acneiform 28.92 10.86 36 92186 4960 63391840
Post procedural diarrhoea 28.75 10.86 15 92207 577 63396223
Ventricular fibrillation 28.42 10.86 57 92165 11810 63384990
Oral candidiasis 28.26 10.86 85 92137 22713 63374087
Mydriasis 28.12 10.86 57 92165 11899 63384901
Female genital tract fistula 28.06 10.86 44 92178 7515 63389285
Wrong technique in product usage process 27.43 10.86 30 92192 62310 63334490
Hepatic enzyme increased 27.22 10.86 177 92045 202151 63194649
Sarcoidosis 27.20 10.86 42 92180 7080 63389720
Blister 27.13 10.86 97 92125 129717 63267083
Cardiotoxicity 27.10 10.86 46 92176 8392 63388408
Electrolyte imbalance 26.94 10.86 77 92145 19999 63376801
Palmar-plantar erythrodysaesthesia syndrome 26.84 10.86 84 92138 22931 63373869
Fatigue 26.69 10.86 1559 90663 886469 62510331
Headache 26.23 10.86 710 91512 632531 62764269
Brain injury 26.15 10.86 41 92181 7002 63389798
Therapeutic reaction time decreased 26.05 10.86 24 92198 2346 63394454
Reflux gastritis 25.84 10.86 18 92204 1177 63395623
Overdose 25.25 10.86 267 91955 114811 63281989
Hypophagia 25.17 10.86 101 92121 31158 63365642
Pregnancy 25.12 10.86 11 92211 36825 63359975
Colitis ulcerative 24.89 10.86 89 92133 26002 63370798
Immune-mediated enterocolitis 24.42 10.86 22 92200 2089 63394711
Sedation 24.31 10.86 13 92209 38796 63358004
Intentional product use issue 23.88 10.86 100 92122 127792 63269008
Ear infection 23.65 10.86 13 92209 38200 63358600
Pulmonary thrombosis 23.53 10.86 44 92178 8658 63388142
Injection site bruising 23.51 10.86 16 92206 41894 63354906
Injection site swelling 23.10 10.86 21 92201 47551 63349249
Hypocalcaemia 22.82 10.86 99 92123 31614 63365186
Atrioventricular block first degree 22.51 10.86 39 92183 7234 63389566
Accidental exposure to product 22.46 10.86 6 92216 27399 63369401
Abdominal distension 22.42 10.86 208 92014 86407 63310393
Loss of personal independence in daily activities 22.17 10.86 70 92152 97220 63299580
Prescribed overdose 22.05 10.86 11 92211 34142 63362658
Obesity 21.97 10.86 8 92214 29944 63366856
Haematochezia 21.89 10.86 143 92079 53401 63343399
Skin fissures 21.85 10.86 50 92172 11338 63385462
Thymus disorder 21.74 10.86 10 92212 291 63396509
Condition aggravated 21.65 10.86 433 91789 401784 62995016
Drug use disorder 21.33 10.86 31 92191 4953 63391847
Bone hypertrophy 21.33 10.86 11 92211 413 63396387
Enteritis 21.29 10.86 41 92181 8245 63388555
Neutrophil count decreased 20.88 10.86 147 92075 56259 63340541
Drug resistance 20.84 10.86 4 92218 22929 63373871
Liver injury 20.69 10.86 35 92187 60485 63336315
Plasma cell myeloma 20.64 10.86 105 92117 35800 63361000
Blood potassium increased 20.59 10.86 66 92156 18243 63378557
Large intestine polyp 20.52 10.86 40 92182 8117 63388683
Rales 20.35 10.86 52 92170 12645 63384155
Gastrointestinal sounds abnormal 20.02 10.86 27 92195 4024 63392776
Palmar erythema 19.63 10.86 18 92204 1749 63395051
Nail disorder 19.53 10.86 52 92170 12963 63383837
Bone cyst 19.47 10.86 20 92202 2234 63394566
Short-bowel syndrome 19.46 10.86 11 92211 497 63396303
Large intestine perforation 19.43 10.86 40 92182 8442 63388358
Osteopenia 19.31 10.86 68 92154 19717 63377083
No adverse event 19.26 10.86 19 92203 41386 63355414
Rhinovirus infection 19.14 10.86 28 92194 4501 63392299
Pleural effusion 18.94 10.86 213 92009 92997 63303803
Laryngitis viral 18.74 10.86 6 92216 62 63396738
Joint range of motion decreased 18.70 10.86 12 92210 32416 63364384
Coronary artery disease 18.65 10.86 12 92210 32365 63364435
Dry eye 18.62 10.86 112 92110 40649 63356151
Gastrointestinal procedural complication 18.55 10.86 8 92214 199 63396601
Femur fracture 18.47 10.86 20 92202 41736 63355064
Megacolon 18.40 10.86 18 92204 1897 63394903
Foetal exposure during pregnancy 18.20 10.86 12 92210 31950 63364850
Asthenia 18.18 10.86 705 91517 382899 63013901
Sinus arrest 18.13 10.86 18 92204 1931 63394869
Pruritus 18.01 10.86 394 91828 361059 63035741
Gastroenteropancreatic neuroendocrine tumour disease 17.99 10.86 5 92217 30 63396770
Defaecation urgency 17.91 10.86 26 92196 4149 63392651
Injury 17.91 10.86 51 92171 73196 63323604
Plantar erythema 17.88 10.86 8 92214 218 63396582
Gait inability 17.76 10.86 31 92191 52928 63343872
Pulmonary fibrosis 17.69 10.86 19 92203 39790 63357010
Nail infection 17.61 10.86 20 92202 2503 63394297
Muscle spasticity 17.43 10.86 5 92217 21789 63375011
Inflammatory bowel disease 17.42 10.86 25 92197 3948 63392852
Gastritis 17.36 10.86 103 92119 37200 63359600
Large intestinal obstruction 17.24 10.86 19 92203 2300 63394500
Product quality issue 17.22 10.86 16 92206 35849 63360951
Small intestine ulcer 17.20 10.86 9 92213 348 63396452
Fistula 17.11 10.86 43 92179 10350 63386450
Hypermagnesaemia 17.11 10.86 13 92209 973 63395827
Intestinal fibrosis 17.07 10.86 7 92215 153 63396647
Clostridium difficile colitis 16.99 10.86 67 92155 20502 63376298
Catheter site haemorrhage 16.99 10.86 22 92200 3153 63393647
Cyst 16.94 10.86 52 92170 14047 63382753
Depressive symptom 16.81 10.86 25 92197 4077 63392723
Food interaction 16.68 10.86 12 92210 826 63395974
Stoma site ulcer 16.49 10.86 8 92214 263 63396537
Ileus 16.49 10.86 53 92169 14672 63382128
Productive cough 16.46 10.86 152 92070 63056 63333744
Ileal stenosis 16.27 10.86 16 92206 1697 63395103
Migraine 16.23 10.86 86 92136 103260 63293540
Malnutrition 16.18 10.86 54 92168 15244 63381556
Pancreatitis chronic 16.17 10.86 19 92203 2465 63394335
Gastroenteritis 16.16 10.86 79 92143 26511 63370289
Cor pulmonale acute 16.14 10.86 9 92213 396 63396404
Paronychia 16.13 10.86 29 92193 5536 63391264
Bursitis 16.10 10.86 18 92204 37023 63359777
Rectal abscess 16.10 10.86 14 92208 1269 63395531
Drug eruption 16.03 10.86 11 92211 28683 63368117
Cardiac murmur 15.95 10.86 52 92170 14500 63382300
Platelet count decreased 15.92 10.86 247 91975 115875 63280925
Autoimmune nephritis 15.79 10.86 9 92213 413 63396387
Peripheral pulse decreased 15.76 10.86 5 92217 50 63396750
Rhinitis allergic 15.75 10.86 45 92177 11682 63385118
Road traffic accident 15.71 10.86 18 92204 36614 63360186
Therapy non-responder 15.66 10.86 57 92165 75844 63320956
Biliary sepsis 15.55 10.86 12 92210 919 63395881
C-reactive protein abnormal 15.44 10.86 27 92195 46069 63350731
Faecaloma 15.39 10.86 35 92187 7906 63388894
Hypovolaemia 15.37 10.86 42 92180 10631 63386169
Influenza like illness 15.28 10.86 48 92174 66776 63330024
Intestinal perforation 15.20 10.86 45 92177 11918 63384882
Thrombocytopenia 15.18 10.86 306 91916 150851 63245949
Paralysis recurrent laryngeal nerve 15.17 10.86 5 92217 57 63396743
Foot deformity 15.14 10.86 11 92211 27842 63368958
Peritoneal perforation 15.12 10.86 6 92216 120 63396680
Hepatic lesion 15.10 10.86 26 92196 4799 63392001
Unmasking of previously unidentified disease 15.05 10.86 12 92210 964 63395836
Aspiration 14.93 10.86 42 92180 10809 63385991
Cystitis noninfective 14.76 10.86 12 92210 991 63395809
Dysgeusia 14.61 10.86 117 92105 46593 63350207
Radiculopathy 14.57 10.86 36 92186 8575 63388225
Lacrimation increased 14.54 10.86 64 92158 20567 63376233
Pleural calcification 14.53 10.86 3 92219 3 63396797
Creatinine renal clearance decreased 14.49 10.86 3 92219 16305 63380495
Soft tissue swelling 14.46 10.86 13 92209 1231 63395569
Tenderness 14.39 10.86 68 92154 22510 63374290
Musculoskeletal pain 14.37 10.86 77 92145 92200 63304600
Haemorrhoids 14.33 10.86 67 92155 22083 63374717
Hyperglycaemia 14.28 10.86 107 92115 41760 63355040
Congenital knee deformity 14.18 10.86 5 92217 71 63396729
White blood cell count decreased 14.10 10.86 282 91940 138822 63257978
Food refusal 14.04 10.86 8 92214 367 63396433
Gastroenteritis bacterial 13.94 10.86 8 92214 372 63396428
Piloerection 13.85 10.86 8 92214 377 63396423
Injection site rash 13.83 10.86 5 92217 18804 63377996
Cytomegalovirus colitis 13.58 10.86 17 92205 2355 63394445
Hypercholesterolaemia 13.58 10.86 7 92215 21327 63375473
Self-injurious ideation 13.57 10.86 18 92204 2641 63394159
Hyperchlorhydria 13.52 10.86 15 92207 1829 63394971
Joint effusion 13.49 10.86 4 92218 17056 63379744
Urosepsis 13.46 10.86 58 92164 18466 63378334
Diarrhoea haemorrhagic 13.44 10.86 36 92186 9006 63387794
Nail bed tenderness 13.40 10.86 8 92214 401 63396399
Ureteric obstruction 13.35 10.86 15 92207 1855 63394945
Autonomic neuropathy 13.25 10.86 12 92210 1147 63395653
Osteoporosis 13.24 10.86 41 92181 57297 63339503
Dysuria 13.12 10.86 89 92133 33649 63363151
Foetal arrhythmia 13.09 10.86 6 92216 173 63396627
Onychalgia 13.01 10.86 11 92211 960 63395840
Paraesthesia 12.83 10.86 156 92066 156810 63239990
Tachycardia 12.81 10.86 242 91980 117914 63278886
Injection site haemorrhage 12.70 10.86 10 92212 24304 63372496
Tumour inflammation 12.70 10.86 4 92218 39 63396761
Renal pain 12.69 10.86 29 92193 6570 63390230
Cellulitis 12.67 10.86 178 92044 81780 63315020
Anxiety 12.66 10.86 231 91991 217310 63179490
Blood sodium decreased 12.62 10.86 69 92153 24183 63372617
Inflammation 12.62 10.86 69 92153 82204 63314596
Gluten sensitivity 12.62 10.86 9 92213 611 63396189
Long QT syndrome congenital 12.60 10.86 5 92217 100 63396700
Accidental poisoning 12.52 10.86 9 92213 619 63396181
Mucosal infection 12.40 10.86 6 92216 196 63396604
Serotonin syndrome 12.40 10.86 14 92208 28668 63368132
Odynophagia 12.35 10.86 31 92191 7455 63389345
Stoma site extravasation 12.35 10.86 7 92215 318 63396482
Protein total decreased 12.32 10.86 27 92195 5950 63390850
Drug ineffective for unapproved indication 12.30 10.86 19 92203 34044 63362756
Prescribed underdose 12.29 10.86 15 92207 29674 63367126
Device related bacteraemia 12.26 10.86 6 92216 201 63396599
Crohn's disease 12.25 10.86 24 92198 4889 63391911
Osteosclerosis 12.23 10.86 21 92201 3867 63392933
Hip fracture 12.22 10.86 79 92143 29395 63367405
Abortion spontaneous 12.18 10.86 32 92190 47163 63349637
Electrocardiogram abnormal 12.11 10.86 35 92187 9144 63387656
Forced expiratory volume decreased 12.06 10.86 24 92198 4944 63391856
Catheter site bruise 12.05 10.86 8 92214 483 63396317
Tubulointerstitial nephritis 11.99 10.86 7 92215 19896 63376904
Escherichia test positive 11.95 10.86 16 92206 2368 63394432
Peritoneal disorder 11.89 10.86 8 92214 494 63396306
Pharyngo-oesophageal diverticulum 11.80 10.86 3 92219 12 63396788
Faecalith 11.80 10.86 3 92219 12 63396788
Gait disturbance 11.79 10.86 191 92031 182987 63213813
Amputation 11.79 10.86 6 92216 219 63396581
Injection site urticaria 11.69 10.86 3 92219 14070 63382730
Alveolar bone resorption 11.66 10.86 4 92218 52 63396748
Periventricular leukomalacia 11.53 10.86 5 92217 126 63396674
Retching 11.53 10.86 47 92175 14598 63382202
Suicidal ideation 11.53 10.86 49 92173 62372 63334428
Product dose omission issue 11.48 10.86 256 91966 234057 63162743
Anaemia of malignant disease 11.43 10.86 8 92214 527 63396273
Hyponatraemia 11.39 10.86 227 91995 111673 63285127
Ataxia 11.37 10.86 48 92174 15147 63381653
Lupus-like syndrome 11.36 10.86 4 92218 15291 63381509
Enterocutaneous fistula 11.36 10.86 12 92210 1385 63395415
Status epilepticus 11.29 10.86 4 92218 15229 63381571
Autoimmune colitis 11.24 10.86 8 92214 541 63396259
Presyncope 11.23 10.86 74 92148 27711 63369089
Hiccups 11.23 10.86 15 92207 2216 63394584
Depressed mood 11.15 10.86 98 92124 40093 63356707
Perforation 11.14 10.86 11 92211 1172 63395628
Accidental exposure to product by child 11.06 10.86 11 92211 1182 63395618
Fracture pain 11.05 10.86 9 92213 745 63396055
Ulcer 11.01 10.86 13 92209 26094 63370706
Motion sickness 11.00 10.86 10 92212 961 63395839
Taste disorder 10.88 10.86 44 92178 13618 63383182

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Diarrhoea 628.41 11.21 1685 53984 388227 34513035
Torsade de pointes 281.14 11.21 163 55506 7046 34894216
Electrocardiogram QT prolonged 220.48 11.21 298 55371 40654 34860608
Electrocardiogram QRS complex prolonged 207.84 11.21 117 55552 4777 34896485
Drug abuse 200.52 11.21 469 55200 98627 34802635
Dehydration 190.67 11.21 545 55124 129424 34771838
Intentional overdose 160.72 11.21 266 55403 43408 34857854
Colitis 154.04 11.21 241 55428 37509 34863753
Ventricular tachycardia 146.95 11.21 196 55473 26383 34874879
Abdominal pain 113.32 11.21 538 55131 163080 34738182
Drug ineffective 77.58 11.21 420 55249 456331 34444931
Small intestinal obstruction 70.71 11.21 102 55567 14764 34886498
Intestinal obstruction 69.57 11.21 128 55541 22694 34878568
Decreased appetite 68.21 11.21 476 55193 165916 34735346
Vascular device infection 65.66 11.21 54 55615 4131 34897131
Blood mercury abnormal 64.04 11.21 21 55648 213 34901049
5-hydroxyindolacetic acid in urine increased 62.11 11.21 21 55648 236 34901026
Intentional self-injury 61.90 11.21 92 55577 13679 34887583
Brugada syndrome 59.77 11.21 28 55641 773 34900489
Completed suicide 56.66 11.21 44 55625 98124 34803138
Overdose 55.50 11.21 289 55380 90770 34810492
Drug use disorder 55.38 11.21 49 55620 4142 34897120
Conduction disorder 55.13 11.21 37 55632 2073 34899189
Immune-mediated enterocolitis 50.06 11.21 39 55630 2760 34898502
Vomiting 49.56 11.21 607 55062 247014 34654248
Fatigue 49.38 11.21 846 54823 369807 34531455
Enteritis 46.45 11.21 61 55608 8081 34893181
Alveolar lung disease 43.40 11.21 18 55651 368 34900894
Electrolyte imbalance 42.87 11.21 80 55589 14332 34886930
Colitis microscopic 42.75 11.21 33 55636 2304 34898958
Foetal exposure during pregnancy 40.82 11.21 6 55663 38095 34863167
Weight decreased 39.58 11.21 442 55227 175859 34725403
Pancreatic enzyme abnormality 38.04 11.21 11 55658 70 34901192
Pulmonary interstitial emphysema syndrome 35.08 11.21 17 55652 507 34900755
Rheumatoid arthritis 34.71 11.21 9 55660 38229 34863033
Electrocardiogram T wave alternans 34.46 11.21 8 55661 17 34901245
Treatment failure 33.81 11.21 16 55653 46681 34854581
Nausea 33.67 11.21 742 54927 339166 34562096
Pouchitis 33.41 11.21 18 55651 673 34900589
Stomatitis 33.19 11.21 145 55524 42369 34858893
Frequent bowel movements 33.18 11.21 67 55602 12720 34888542
Product use in unapproved indication 32.82 11.21 88 55581 117411 34783851
Low density lipoprotein decreased 32.18 11.21 21 55648 1122 34900140
Colitis ulcerative 32.02 11.21 77 55592 16443 34884819
Abscess intestinal 31.77 11.21 24 55645 1622 34899640
Cardiotoxicity 31.73 11.21 42 55627 5606 34895656
Drug hypersensitivity 31.20 11.21 50 55619 80479 34820783
Hypomagnesaemia 30.35 11.21 90 55579 21761 34879501
Ileus 29.96 11.21 75 55594 16424 34884838
Flatulence 29.15 11.21 87 55582 21111 34880151
Unmasking of previously unidentified disease 28.73 11.21 18 55651 896 34900366
Myocardial infarction 28.58 11.21 98 55571 120987 34780275
Enterocolitis 28.31 11.21 48 55621 7978 34893284
Cardiac arrest 28.27 11.21 255 55414 95904 34805358
Hepatic neoplasm 27.90 11.21 24 55645 1953 34899309
Blood potassium decreased 27.01 11.21 76 55593 17839 34883423
Ventricular arrhythmia 26.38 11.21 38 55631 5490 34895772
Accidental overdose 26.14 11.21 81 55588 20059 34881203
Gastrointestinal stoma complication 24.91 11.21 19 55650 1303 34899959
Drug interaction 24.42 11.21 236 55433 225710 34675552
Gastrointestinal stoma output increased 24.15 11.21 8 55661 84 34901178
Clostridium difficile colitis 23.98 11.21 67 55602 15663 34885599
Drug withdrawal syndrome 23.22 11.21 77 55592 19757 34881505
Generalised oedema 23.16 11.21 57 55612 12351 34888911
Enterocolonic fistula 23.04 11.21 8 55661 98 34901164
Intestinal intraepithelial lymphocytes increased 22.81 11.21 9 55660 161 34901101
Faecal calprotectin increased 22.75 11.21 24 55645 2520 34898742
Respiratory depression 22.64 11.21 67 55602 16178 34885084
Abdominal distension 22.53 11.21 165 55504 58327 34842935
Autoimmune colitis 22.31 11.21 16 55653 998 34900264
Asthma 22.30 11.21 21 55648 42635 34858627
Wheezing 22.09 11.21 20 55649 41382 34859880
Device related infection 22.07 11.21 69 55600 17168 34884094
Sedation 20.97 11.21 4 55665 21002 34880260
Therapeutic product effect decreased 20.76 11.21 15 55654 34728 34866534
Hepatic haematoma 20.72 11.21 11 55658 399 34900863
Diarrhoea haemorrhagic 20.68 11.21 38 55631 6726 34894536
Intestinal perforation 20.62 11.21 45 55624 9015 34892247
Expired product administered 20.57 11.21 26 55643 3315 34897947
Gastrointestinal stoma output decreased 20.52 11.21 7 55662 81 34901181
Pyrexia 20.34 11.21 683 54986 332330 34568932
Drug resistance 20.17 11.21 8 55661 25919 34875343
Angioedema 20.01 11.21 18 55651 37356 34863906
Cryptitis 19.96 11.21 9 55660 227 34901035
Anal fissure 19.76 11.21 29 55640 4261 34897001
Atrioventricular block first degree 19.62 11.21 35 55634 6057 34895205
Palmar-plantar erythrodysaesthesia syndrome 19.48 11.21 65 55604 16730 34884532
Gastrointestinal obstruction 19.38 11.21 14 55655 883 34900379
Hypovolaemia 18.94 11.21 44 55625 9190 34892072
Dysgeusia 18.90 11.21 88 55581 26409 34874853
Bacterial diarrhoea 18.65 11.21 6 55663 57 34901205
Wrong technique in product usage process 18.48 11.21 18 55651 35968 34865294
Pneumonitis 18.23 11.21 104 55565 33774 34867488
Drug dispensed to wrong patient 18.20 11.21 11 55658 513 34900749
Psoriasis 18.15 11.21 21 55648 38791 34862471
Microvillous inclusion disease 18.11 11.21 8 55661 192 34901070
Musculoskeletal stiffness 18.06 11.21 29 55640 46651 34854611
Apoptosis 17.92 11.21 10 55659 401 34900861
Dyschromatopsia 17.92 11.21 10 55659 401 34900861
Peripheral embolism 17.45 11.21 14 55655 1034 34900228
Probiotic therapy 17.35 11.21 7 55662 133 34901129
Colorectal cancer metastatic 17.03 11.21 12 55657 728 34900534
Prostate cancer 16.93 11.21 23 55646 39626 34861636
Immune-mediated hepatitis 16.52 11.21 19 55650 2196 34899066
Bladder cancer 16.46 11.21 3 55666 16275 34884987
Therapeutic product effect incomplete 16.36 11.21 35 55634 50506 34850756
Abdominal abscess 16.11 11.21 26 55643 4149 34897113
Gastroenteritis 16.06 11.21 55 55614 14345 34886917
Noninfective gingivitis 16.04 11.21 9 55660 365 34900897
Depression 15.96 11.21 90 55579 97008 34804254
Gastroenteritis staphylococcal 15.93 11.21 8 55661 258 34901004
Injection site erythema 15.93 11.21 3 55666 15896 34885366
Miosis 15.92 11.21 42 55627 9493 34891769
Malignant neoplasm progression 15.91 11.21 212 55457 87834 34813428
Blood magnesium decreased 15.89 11.21 33 55636 6390 34894872
Diffuse alveolar damage 15.85 11.21 19 55650 2295 34898967
Basosquamous carcinoma 15.65 11.21 6 55663 99 34901163
Rhabdomyolysis 15.51 11.21 56 55613 68107 34833155
Hypokalaemia 15.40 11.21 151 55518 58063 34843199
Piloerection 15.29 11.21 7 55662 183 34901079
Right ventricular dilatation 15.28 11.21 11 55658 690 34900572
Aggression 15.27 11.21 24 55645 38940 34862322
Electrocardiogram PR prolongation 14.99 11.21 12 55657 883 34900379
Syncope 14.82 11.21 216 55453 91235 34810027
Biliary obstruction 14.79 11.21 20 55649 2725 34898537
Steatorrhoea 14.71 11.21 11 55658 732 34900530
Drug ineffective for unapproved indication 14.49 11.21 10 55659 23705 34877557
Drug delivery device placement 14.28 11.21 6 55663 127 34901135
Pancreatic failure 14.01 11.21 11 55658 787 34900475
Stoma complication 13.89 11.21 8 55661 341 34900921
Subileus 13.82 11.21 21 55648 3182 34898080
Necrotising ulcerative gingivostomatitis 13.79 11.21 5 55664 70 34901192
Intestinal fistula 13.78 11.21 12 55657 993 34900269
Anal fistula infection 13.76 11.21 4 55665 26 34901236
Gastrointestinal inflammation 13.73 11.21 22 55647 3489 34897773
Proctalgia 13.69 11.21 29 55640 5694 34895568
CSF white blood cell count decreased 13.50 11.21 4 55665 28 34901234
Interstitial lung disease 13.34 11.21 56 55613 65226 34836036
Eye infection fungal 13.26 11.21 8 55661 372 34900890
Cardiac failure congestive 13.24 11.21 78 55591 83192 34818070
Non-small cell lung cancer 13.15 11.21 23 55646 3917 34897345
Retinal ischaemia 13.13 11.21 8 55661 379 34900883
Blood creatine phosphokinase increased 12.96 11.21 33 55636 44824 34856438
Sepsis 12.92 11.21 352 55317 166209 34735053
Clostridium difficile infection 12.92 11.21 62 55607 18836 34882426
Cognitive disorder 12.91 11.21 16 55653 28677 34872585
Short-bowel syndrome 12.89 11.21 7 55662 266 34900996
Malnutrition 12.84 11.21 47 55622 12662 34888600
Condition aggravated 12.84 11.21 222 55447 191974 34709288
Crohn's disease 12.84 11.21 20 55649 3097 34898165
Psychotic disorder 12.82 11.21 12 55657 24440 34876822
Mixed dementia 12.77 11.21 7 55662 271 34900991
Multiple organ dysfunction syndrome 12.56 11.21 71 55598 76495 34824767
Joint swelling 12.47 11.21 51 55618 59839 34841423
Dependence 12.39 11.21 12 55657 1138 34900124
Anal abscess 12.36 11.21 30 55639 6443 34894819
Drug reaction with eosinophilia and systemic symptoms 12.31 11.21 21 55648 32991 34868271
Pain in jaw 12.16 11.21 47 55622 12993 34888269
Arrhythmia 12.11 11.21 98 55571 35710 34865552
Blood cholesterol increased 12.10 11.21 9 55660 20534 34880728
Nephroangiosclerosis 12.05 11.21 6 55663 190 34901072
Biopsy 11.99 11.21 7 55662 306 34900956
Seizure 11.95 11.21 108 55561 104749 34796513
Gastrointestinal sounds abnormal 11.95 11.21 16 55653 2159 34899103
Biopsy intestine abnormal 11.95 11.21 3 55666 10 34901252
Sleep apnoea syndrome 11.85 11.21 9 55660 20312 34880950
Periodontal disease 11.75 11.21 10 55659 802 34900460
Body surface area decreased 11.73 11.21 3 55666 11 34901251
Hyperammonaemia 11.62 11.21 29 55640 6338 34894924
Intussusception 11.55 11.21 9 55660 637 34900625
Fistula of small intestine 11.52 11.21 8 55661 474 34900788
Hot flush 11.44 11.21 58 55611 18008 34883254
Tachycardia 11.37 11.21 194 55475 84578 34816684
Pyomyositis 11.37 11.21 6 55663 215 34901047
Pneumonia 11.35 11.21 695 54974 361932 34539330
Oesophageal varices haemorrhage 11.34 11.21 19 55650 3127 34898135
Cytomegalovirus infection 11.32 11.21 15 55654 26120 34875142
Large intestine infection 11.29 11.21 13 55656 1505 34899757

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Diarrhoea 1109.12 10.32 3455 121777 877034 78742122
Dehydration 407.29 10.32 1075 124157 247112 79372044
Torsade de pointes 381.87 10.32 284 124948 19028 79600128
Colitis 319.56 10.32 479 124753 72828 79546328
Electrocardiogram QT prolonged 317.42 10.32 535 124697 89851 79529305
Ventricular tachycardia 290.86 10.32 344 124888 41591 79577565
Drug abuse 255.76 10.32 694 124538 161997 79457159
Electrocardiogram QRS complex prolonged 193.59 10.32 150 125082 10683 79608473
Vomiting 191.64 10.32 1736 123496 664092 78955064
Abdominal pain 187.49 10.32 1148 124084 388421 79230735
Drug ineffective 185.68 10.32 972 124260 1079941 78539215
Nausea 179.27 10.32 2289 122943 954907 78664249
Completed suicide 177.31 10.32 82 125150 245685 79373471
Decreased appetite 161.48 10.32 1004 124228 341414 79277742
Maternal exposure during pregnancy 149.53 10.32 19 125213 136519 79482637
Hypomania 149.24 10.32 111 125121 7433 79611723
Systemic lupus erythematosus 139.85 10.32 14 125218 121135 79498021
Weight decreased 134.78 10.32 987 124245 354211 79264945
Small intestinal obstruction 130.06 10.32 186 125046 27086 79592070
Jaundice cholestatic 125.39 10.32 119 125113 11165 79607991
Contraindicated product administered 120.85 10.32 48 125184 157490 79461666
Hypomagnesaemia 120.80 10.32 243 124989 46668 79572488
Vascular device infection 117.30 10.32 110 125122 10166 79608990
Hypokalaemia 114.46 10.32 489 124743 143551 79475605
Gastrooesophageal reflux disease 112.46 10.32 390 124842 103856 79515300
Arthropathy 111.74 10.32 70 125162 177041 79442115
Therapeutic product effect decreased 111.59 10.32 59 125173 163804 79455352
Drug intolerance 109.46 10.32 153 125079 263966 79355190
Total lung capacity increased 106.69 10.32 58 125174 2240 79616916
Intestinal obstruction 102.70 10.32 216 125016 42804 79576352
Gastrointestinal stoma complication 101.89 10.32 59 125173 2578 79616578
Brugada syndrome 98.33 10.32 45 125187 1193 79617963
Schizophrenia 97.79 10.32 121 125111 15319 79603837
Drug hypersensitivity 96.53 10.32 203 125029 298713 79320443
Rheumatoid arthritis 94.37 10.32 113 125119 208357 79410799
Pericarditis 93.69 10.32 24 125208 104212 79514944
Colitis microscopic 92.89 10.32 99 125133 10669 79608487
Frequent bowel movements 89.55 10.32 164 125068 29375 79589781
Pneumonia viral 89.45 10.32 90 125142 9068 79610088
Synovitis 86.54 10.32 66 125166 150668 79468488
Pneumonia aspiration 86.11 10.32 266 124966 66701 79552455
Intentional overdose 81.29 10.32 356 124876 105604 79513552
Conduction disorder 81.28 10.32 56 125176 3323 79615833
Psoriatic arthropathy 78.17 10.32 14 125218 77985 79541171
Wound 77.38 10.32 43 125189 116136 79503020
Flatulence 74.93 10.32 190 125042 42534 79576622
Joint swelling 74.47 10.32 220 125012 288426 79330730
Treatment failure 74.42 10.32 95 125137 170391 79448765
Accidental overdose 71.49 10.32 178 125054 39403 79579753
Helicobacter infection 70.97 10.32 12 125220 69692 79549464
Lethargy 70.84 10.32 284 124948 81008 79538148
Mucosal inflammation 70.69 10.32 270 124962 75310 79543846
Drug use disorder 70.18 10.32 77 125155 8574 79610582
Immune-mediated enterocolitis 69.63 10.32 59 125173 4771 79614385
Neuropathy peripheral 69.38 10.32 419 124813 140886 79478270
Discomfort 68.35 10.32 58 125174 125559 79493597
Constipation 68.23 10.32 712 124520 282338 79336818
Exposure during pregnancy 67.98 10.32 37 125195 101095 79518061
Soft tissue disorder 67.92 10.32 51 125181 3464 79615692
Malignant neoplasm progression 67.89 10.32 405 124827 135585 79483571
Musculoskeletal stiffness 65.14 10.32 109 125123 174899 79444257
Blood mercury abnormal 64.33 10.32 21 125211 213 79618943
Overdose 64.17 10.32 502 124730 183704 79435452
Febrile neutropenia 63.89 10.32 598 124634 230401 79388755
Cardiotoxicity 63.60 10.32 87 125145 12152 79607004
Fatigue 63.14 10.32 1907 123325 927820 78691336
Pneumonia 62.72 10.32 1416 123816 658830 78960326
5-hydroxyindolacetic acid in urine increased 62.24 10.32 21 125211 238 79618918
Muscle injury 60.49 10.32 4 125228 48557 79570599
Red blood cell sedimentation rate increased 59.63 10.32 3 125229 45939 79573217
Glossodynia 59.62 10.32 45 125187 103292 79515864
Blood magnesium decreased 59.58 10.32 99 125133 16413 79602743
Pneumonitis 59.05 10.32 220 125012 60640 79558516
Coma 59.01 10.32 313 124919 100336 79518820
Brain stem glioma 58.53 10.32 19 125213 189 79618967
Oral pain 58.48 10.32 144 125088 31654 79587502
Blood bilirubin increased 58.20 10.32 232 125000 66000 79553156
Segmental diverticular colitis 57.65 10.32 18 125214 156 79619000
Enteritis 57.47 10.32 91 125141 14492 79604664
Ventricular arrhythmia 57.15 10.32 70 125162 8770 79610386
Drug interaction 56.83 10.32 400 124832 414783 79204373
Product use in unapproved indication 56.79 10.32 202 125030 250157 79368999
Macular degeneration 56.75 10.32 79 125153 11217 79607939
Pedal pulse abnormal 55.73 10.32 18 125214 176 79618980
Cardiac arrest 55.05 10.32 460 124772 171636 79447520
Presbyacusis 54.55 10.32 40 125192 2620 79616536
Enterocolitis 53.70 10.32 88 125144 14424 79604732
Proctitis 53.48 10.32 58 125174 6374 79612782
Arthralgia 52.82 10.32 609 124623 571194 79047962
Electrolyte imbalance 52.77 10.32 136 125096 30745 79588411
Pouchitis 51.66 10.32 27 125205 962 79618194
Cholelithiasis 51.62 10.32 191 125041 52473 79566683
Pyrexia 51.43 10.32 1412 123820 677297 78941859
Nail dystrophy 51.05 10.32 27 125205 986 79618170
Blood magnesium increased 50.89 10.32 43 125189 3463 79615693
Swelling 50.38 10.32 173 125059 216538 79402618
Pain 49.70 10.32 792 124440 703010 78916146
Device related infection 49.56 10.32 142 125090 34152 79585004
Injection site erythema 49.16 10.32 31 125201 78166 79540990
Clostridium difficile infection 48.91 10.32 163 125069 42522 79576634
Syncope 47.83 10.32 461 124771 178988 79440168
Weight increased 47.49 10.32 249 124983 277137 79342019
Chronic sinusitis 46.87 10.32 78 125154 12948 79606208
Pleural thickening 46.25 10.32 38 125194 2944 79616212
Impaired healing 45.83 10.32 42 125190 87613 79531543
Injection site pain 45.47 10.32 84 125148 129754 79489402
Dyspepsia 45.16 10.32 309 124923 108378 79510778
Blood potassium decreased 45.01 10.32 168 125064 46344 79572812
Respiration abnormal 44.52 10.32 58 125174 7730 79611426
Type 2 diabetes mellitus 44.45 10.32 17 125215 57105 79562051
Hip arthroplasty 44.38 10.32 3 125229 35753 79583403
Heart sounds 43.79 10.32 24 125208 942 79618214
Colitis ulcerative 43.72 10.32 137 125095 34605 79584551
Asthma-chronic obstructive pulmonary disease overlap syndrome 43.69 10.32 38 125194 3183 79615973
Appetite disorder 43.25 10.32 57 125175 7682 79611474
Sedation 42.85 10.32 14 125218 51881 79567275
Atrioventricular block first degree 42.56 10.32 73 125159 12418 79606738
Gastrointestinal stoma output increased 42.55 10.32 18 125214 393 79618763
Rectal haemorrhage 42.49 10.32 234 124998 76066 79543090
Calcium ionised decreased 42.47 10.32 20 125212 567 79618589
Mobility decreased 41.93 10.32 80 125152 122095 79497061
Long QT syndrome 41.51 10.32 49 125183 5906 79613250
Palmar-plantar erythrodysaesthesia syndrome 41.09 10.32 130 125102 33004 79586152
Neutropenic sepsis 41.00 10.32 114 125118 26950 79592206
Sepsis 40.93 10.32 622 124610 268806 79350350
Vaginal flatulence 40.33 10.32 33 125199 2542 79616614
Wrong technique in product usage process 40.31 10.32 34 125198 73841 79545315
Prolonged expiration 40.19 10.32 25 125207 1246 79617910
Unmasking of previously unidentified disease 40.09 10.32 30 125202 2027 79617129
Procedural pain 39.79 10.32 102 125130 22982 79596174
Sinusitis 39.64 10.32 165 125067 195336 79423820
Injection site pruritus 39.43 10.32 9 125223 42274 79576882
Pleural fibrosis 38.96 10.32 40 125192 4127 79615029
Stoma complication 38.94 10.32 21 125211 798 79618358
Dry skin 37.51 10.32 208 125024 67787 79551369
Abdominal distension 37.28 10.32 318 124914 119332 79499824
Psoriasis 36.96 10.32 52 125180 89535 79529621
Somnolence 36.79 10.32 553 124679 238428 79380728
Alveolar lung disease 36.71 10.32 18 125214 559 79618597
Folliculitis 36.15 10.32 21 125211 55359 79563797
Paraesthesia oral 35.85 10.32 91 125141 20380 79598776
Vaginal discharge 35.72 10.32 51 125181 7412 79611744
Pulmonary interstitial emphysema syndrome 35.33 10.32 17 125215 506 79618650
Anal abscess 34.98 10.32 57 125175 9298 79609858
Deafness neurosensory 34.29 10.32 48 125184 6850 79612306
Hypersensitivity 34.21 10.32 256 124976 261983 79357173
Injection site reaction 34.05 10.32 22 125210 54763 79564393
Myocardial infarction 33.95 10.32 161 125071 183968 79435188
Therapeutic response decreased 33.82 10.32 33 125199 66820 79552336
Drug resistance 33.79 10.32 12 125220 42201 79576955
Obesity 33.72 10.32 7 125225 35118 79584038
Hypophosphataemia 33.30 10.32 87 125145 19826 79599330
Ill-defined disorder 32.77 10.32 33 125199 65842 79553314
Ileus 32.65 10.32 103 125129 26108 79593048
Feeding intolerance 32.59 10.32 19 125213 841 79618315
Pancreatic enzyme abnormality 32.57 10.32 11 125221 125 79619031
Pulmonary embolism 32.42 10.32 412 124820 171242 79447914
Female genital tract fistula 31.85 10.32 43 125189 5932 79613224
Therapeutic reaction time decreased 31.64 10.32 33 125199 3468 79615688
Multiple sclerosis relapse 31.30 10.32 17 125215 46516 79572640
Coronary artery disease 31.22 10.32 34 125198 65440 79553716
Low density lipoprotein decreased 31.18 10.32 21 125211 1200 79617956
Acute kidney injury 30.80 10.32 1049 124183 518355 79100801
Autoimmune colitis 30.15 10.32 23 125209 1600 79617556
Intestinal perforation 30.03 10.32 77 125155 17349 79601807
Gastroenteritis radiation 29.99 10.32 17 125215 713 79618443
Device expulsion 29.80 10.32 3 125229 25858 79593298
Ejection fraction decreased 29.47 10.32 120 125112 34457 79584699
Injection site swelling 29.19 10.32 19 125213 47113 79572043
Injection site bruising 29.04 10.32 14 125218 40988 79578168
Arteriovenous fistula occlusion 28.63 10.32 15 125217 537 79618619
Unresponsive to stimuli 27.72 10.32 166 125066 55622 79563534
Stomatitis 27.61 10.32 352 124880 146405 79472751
Clostridium difficile colitis 27.49 10.32 112 125120 32171 79586985
Disease progression 27.35 10.32 424 124808 183938 79435218
Gastrointestinal sounds abnormal 27.29 10.32 38 125194 5397 79613759
Intentional self-injury 27.23 10.32 112 125120 32307 79586849
Infusion related reaction 27.14 10.32 231 125001 230006 79389150
Skin fissures 27.06 10.32 62 125170 13011 79606145
Hepatic neoplasm 26.94 10.32 30 125202 3396 79615760
Anaemia 26.67 10.32 900 124332 444115 79175041
Diarrhoea haemorrhagic 26.56 10.32 62 125170 13172 79605984
Electrocardiogram T wave alternans 26.30 10.32 8 125224 63 79619093
Dermatitis acneiform 26.00 10.32 52 125180 9941 79609215
Drug withdrawal syndrome 25.37 10.32 115 125117 34603 79584553
Gallbladder polyp 25.22 10.32 17 125215 973 79618183
Drug dispensed to wrong patient 25.18 10.32 15 125217 691 79618465
Abdominal discomfort 25.09 10.32 262 124970 250465 79368691
Blue toe syndrome 24.92 10.32 14 125218 577 79618579
Cardiac failure congestive 24.81 10.32 127 125105 142275 79476881
Haematochezia 24.75 10.32 228 125004 87417 79531739
Hypophagia 24.50 10.32 138 125094 45229 79573927
Hypocalcaemia 24.46 10.32 148 125084 49776 79569380
Cryptitis 24.20 10.32 11 125221 287 79618869
Epigastric discomfort 24.13 10.32 44 125188 7852 79611304
Drug ineffective for unapproved indication 23.99 10.32 27 125205 51211 79567945
Premature delivery 23.98 10.32 4 125228 23463 79595693
Reflux gastritis 23.86 10.32 18 125214 1231 79617925
Faecal calprotectin increased 23.83 10.32 36 125196 5505 79613651
Anal fissure 23.64 10.32 43 125189 7660 79611496
Gait inability 23.51 10.32 35 125197 58882 79560274
C-reactive protein abnormal 23.19 10.32 25 125207 48342 79570814
Pleural effusion 23.06 10.32 338 124894 144924 79474232
Adverse event 22.86 10.32 37 125195 60177 79558979
Urosepsis 22.62 10.32 92 125140 26403 79592753
Pregnancy 22.60 10.32 7 125225 26844 79592312
Headache 22.53 10.32 820 124412 652952 78966204
Hepatotoxicity 22.52 10.32 148 125084 51204 79567952
Hypovolaemia 22.48 10.32 70 125162 17621 79601535
Proctalgia 22.46 10.32 49 125183 9952 79609204
Intestinal intraepithelial lymphocytes increased 22.43 10.32 9 125223 171 79618985
Malnutrition 22.37 10.32 82 125150 22420 79596736
Dysgeusia 22.24 10.32 160 125072 57017 79562139
Urticaria 22.19 10.32 185 125047 185016 79434140
Gastroenteritis 22.06 10.32 109 125123 33973 79585183
Ventricular fibrillation 22.03 10.32 104 125128 31822 79587334
Condition aggravated 21.97 10.32 609 124623 500515 79118641
Osteoporosis 21.74 10.32 32 125200 54080 79565076
Accidental exposure to product 21.72 10.32 11 125221 31311 79587845
Abscess intestinal 21.48 10.32 24 125208 2727 79616429
Piloerection 21.46 10.32 12 125220 490 79618666
Anal incontinence 21.36 10.32 70 125162 18098 79601058
Nasal polyps 21.35 10.32 40 125192 7287 79611869
Tachycardia 21.31 10.32 395 124837 177373 79441783
Therapy non-responder 21.22 10.32 74 125158 92231 79526925
Prescribed overdose 21.21 10.32 17 125215 37866 79581290
Product dose omission issue 21.12 10.32 268 124964 247269 79371887
Thymus disorder 21.12 10.32 10 125222 287 79618869
Fistula 21.09 10.32 56 125176 12884 79606272
Brain injury 21.01 10.32 52 125180 11465 79607691
Faecaloma 20.87 10.32 52 125180 11512 79607644
Arrhythmia 20.77 10.32 166 125066 61106 79558050
Injury 20.73 10.32 58 125174 77438 79541718
Bladder cancer 20.69 10.32 3 125229 19523 79599633
Suicidal ideation 20.52 10.32 57 125175 76283 79542873
Psychotic disorder 20.45 10.32 123 125109 41279 79577877
Urinary tract infection 20.38 10.32 570 124662 273942 79345214
Rhabdomyolysis 20.30 10.32 88 125144 103043 79516113
Neuroleptic malignant syndrome 20.15 10.32 9 125223 27550 79591606
Probiotic therapy 19.94 10.32 8 125224 152 79619004
Joint range of motion decreased 19.83 10.32 14 125218 33268 79585888
Respiratory depression 19.80 10.32 91 125141 27539 79591617
Biliary sepsis 19.79 10.32 18 125214 1599 79617557
Enterocolonic fistula 19.75 10.32 8 125224 156 79619000
Serotonin syndrome 19.73 10.32 25 125207 45002 79574154
Neutropenia 19.60 10.32 591 124641 287119 79332037
Paronychia 19.56 10.32 40 125192 7768 79611388
Hypercholesterolaemia 19.48 10.32 6 125226 23089 79596067
Irritable bowel syndrome 19.45 10.32 43 125189 62198 79556958
Gastrointestinal stoma output decreased 19.42 10.32 8 125224 163 79618993
Gastrointestinal inflammation 19.32 10.32 39 125193 7505 79611651
Loss of personal independence in daily activities 19.31 10.32 89 125143 102491 79516665
Muscle spasticity 19.18 10.32 5 125227 21470 79597686
Bursitis 18.94 10.32 17 125215 35827 79583329
Right ventricular dilatation 18.94 10.32 19 125213 1907 79617249
Mania 18.91 10.32 3 125229 18257 79600899
Sarcoidosis 18.91 10.32 41 125191 8294 79610862
Angioedema 18.83 10.32 59 125173 75976 79543180
Blood creatinine increased 18.75 10.32 345 124887 154712 79464444
Ear infection 18.60 10.32 16 125216 34416 79584740
Laryngitis viral 18.28 10.32 6 125226 62 79619094
Pruritus 18.22 10.32 476 124756 394172 79224984
Post procedural diarrhoea 18.20 10.32 12 125220 662 79618494
Blood creatine phosphokinase increased 18.02 10.32 49 125183 66041 79553115
Oral candidiasis 17.94 10.32 93 125139 29535 79589621
Gastroenteritis staphylococcal 17.80 10.32 9 125223 299 79618857
Hepatic haematoma 17.78 10.32 13 125219 848 79618308
Device related bacteraemia 17.75 10.32 12 125220 690 79618466
Non-small cell lung cancer 17.64 10.32 34 125198 6326 79612830
Drug eruption 17.63 10.32 26 125206 43909 79575247
Injection site haemorrhage 17.58 10.32 11 125221 27859 79591297
Gastrointestinal procedural complication 17.52 10.32 8 125224 211 79618945
Musculoskeletal disorder 17.33 10.32 6 125226 21442 79597714
Microvillous inclusion disease 17.31 10.32 8 125224 217 79618939
Mydriasis 17.29 10.32 64 125168 17579 79601577
Defaecation urgency 17.23 10.32 32 125200 5792 79613364
Nail disorder 17.05 10.32 49 125183 11803 79607353
Large intestine perforation 17.02 10.32 56 125176 14511 79604645
Palmar erythema 16.97 10.32 18 125214 1929 79617227
Megacolon 16.90 10.32 24 125208 3471 79615685
Tumour inflammation 16.83 10.32 5 125227 36 79619120
Abortion spontaneous 16.82 10.32 13 125219 29494 79589662
Rhinorrhoea 16.73 10.32 188 125044 75886 79543270
Niemann-Pick disease 16.48 10.32 5 125227 39 79619117
Large intestinal obstruction 16.46 10.32 23 125209 3276 79615880
Neoplasm progression 16.43 10.32 138 125094 51544 79567612
Gait disturbance 16.12 10.32 229 125003 207277 79411879
Immune-mediated hepatitis 16.07 10.32 24 125208 3632 79615524
Gastroenteropancreatic neuroendocrine tumour disease 16.05 10.32 5 125227 43 79619113
Stoma site ulcer 15.95 10.32 8 125224 261 79618895
Contusion 15.90 10.32 153 125079 148623 79470533
Foot deformity 15.89 10.32 9 125223 24065 79595091
Apoptosis 15.87 10.32 10 125222 510 79618646
Electrocardiogram abnormal 15.81 10.32 60 125172 16677 79602479
Drug reaction with eosinophilia and systemic symptoms 15.80 10.32 50 125182 64194 79554962
Bone cyst 15.76 10.32 23 125209 3410 79615746
Pancreatitis chronic 15.73 10.32 25 125207 3994 79615162
Basosquamous carcinoma 15.62 10.32 6 125226 101 79619055
Cerebral haemorrhage 15.55 10.32 43 125189 57630 79561526
Haematoma 15.55 10.32 37 125195 52158 79566998
Hypermagnesaemia 15.53 10.32 14 125218 1230 79617926
Nail infection 15.51 10.32 19 125213 2380 79616776
Cognitive disorder 15.45 10.32 57 125175 69869 79549287
Blister 15.39 10.32 117 125115 119359 79499797
Gastrointestinal stoma output abnormal 15.30 10.32 6 125226 107 79619049
Plasma cell myeloma 15.26 10.32 139 125093 53120 79566036
Food refusal 15.19 10.32 10 125222 550 79618606
Bacterial diarrhoea 15.18 10.32 7 125225 189 79618967
Small intestine ulcer 15.17 10.32 11 125221 708 79618448
Gluten sensitivity 15.12 10.32 9 125223 414 79618742
Osteopenia 15.07 10.32 63 125169 18301 79600855
Short-bowel syndrome 15.05 10.32 10 125222 559 79618597
Inflammation 15.01 10.32 86 125146 93667 79525489
No adverse event 14.93 10.32 22 125210 37170 79581986
Bone hypertrophy 14.92 10.32 10 125222 567 79618589
Sopor 14.80 10.32 18 125214 32992 79586164
Diabetes mellitus 14.76 10.32 68 125164 78322 79540834
Product quality issue 14.71 10.32 19 125213 33921 79585235
Joint stiffness 14.66 10.32 26 125206 40804 79578352
Renal pain 14.65 10.32 37 125195 8259 79610897
Joint effusion 14.63 10.32 5 125227 18009 79601147
Gastroenteritis bacterial 14.63 10.32 9 125223 440 79618716
Injection site rash 14.55 10.32 5 125227 17949 79601207
Congenital knee deformity 14.54 10.32 4 125228 21 79619135
Lactic acidosis 14.49 10.32 59 125173 70300 79548856
Delusion 14.42 10.32 7 125225 20416 79598740
Taste disorder 14.36 10.32 56 125176 15767 79603389
Asthenia 14.25 10.32 959 124273 510730 79108426
Functional gastrointestinal disorder 14.24 10.32 27 125205 4963 79614193
Cyst 14.24 10.32 51 125181 13789 79605367
Subileus 14.21 10.32 29 125203 5625 79613531
Transposition of the great vessels 14.20 10.32 5 125227 65 79619091
Large intestine polyp 14.09 10.32 48 125184 12660 79606496
Anxiety 13.90 10.32 291 124941 248221 79370935
Rectal abscess 13.89 10.32 17 125215 2128 79617028
Accidental poisoning 13.88 10.32 15 125217 1642 79617514
Fistula of small intestine 13.80 10.32 11 125221 816 79618340
Intentional product misuse 13.77 10.32 218 125014 94947 79524209
Abnormal faeces 13.62 10.32 34 125198 7537 79611619
Impaired work ability 13.51 10.32 7 125225 19674 79599482
Disability 13.48 10.32 5 125227 17115 79602041
Enterocutaneous fistula 13.45 10.32 16 125216 1945 79617211
Neoplasm 13.41 10.32 38 125194 9078 79610078
Failure to thrive 13.36 10.32 45 125187 11799 79607357
Pulmonary fibrosis 13.35 10.32 31 125201 44081 79575075
Sedation complication 13.34 10.32 4 125228 15665 79603491
Carpal tunnel syndrome 13.33 10.32 7 125225 19521 79599635
Ascites 13.26 10.32 179 125053 75383 79543773
Bulimia nervosa 13.25 10.32 7 125225 255 79618901
Bicuspid aortic valve 13.20 10.32 4 125228 31 79619125
Gastritis 13.12 10.32 124 125108 47869 79571287
Prerenal failure 13.11 10.32 22 125210 3676 79615480
Status epilepticus 13.08 10.32 12 125220 25029 79594127
Gastrointestinal obstruction 13.05 10.32 15 125217 1757 79617399
Inflammatory bowel disease 13.05 10.32 28 125204 5623 79613533
Intestinal ulcer 12.95 10.32 16 125216 2022 79617134
Extrapyramidal disorder 12.92 10.32 10 125222 22669 79596487
Acute hepatic failure 12.90 10.32 17 125215 30096 79589060
Bone disorder 12.83 10.32 7 125225 19106 79600050
Cystitis noninfective 12.78 10.32 13 125219 1327 79617829
Cardiac murmur 12.76 10.32 54 125178 15770 79603386
Peritoneal perforation 12.74 10.32 6 125226 170 79618986
Nail bed tenderness 12.73 10.32 8 125224 406 79618750
Creatinine renal clearance decreased 12.69 10.32 7 125225 18995 79600161
Feeling abnormal 12.61 10.32 175 125057 159024 79460132
Sensory disturbance 12.57 10.32 4 125228 15073 79604083
Mixed dementia 12.56 10.32 7 125225 284 79618872
Rash 12.55 10.32 762 124470 577596 79041560
Hair texture abnormal 12.50 10.32 21 125211 3513 79615643
Blood pressure systolic increased 12.30 10.32 160 125072 66826 79552330
Device related sepsis 12.27 10.32 29 125203 6211 79612945
Hepatic lesion 12.25 10.32 31 125201 6928 79612228
Radiculopathy 12.23 10.32 36 125196 8788 79610368
Diffuse alveolar damage 12.20 10.32 21 125211 3583 79615573
Road traffic accident 12.19 10.32 32 125200 43632 79575524
Prostate cancer 12.11 10.32 21 125211 33247 79585909
Hepatic enzyme increased 12.00 10.32 208 125024 182402 79436754
Dry eye 11.94 10.32 99 125133 36832 79582324
Plantar erythema 11.94 10.32 7 125225 313 79618843
Musculoskeletal pain 11.91 10.32 103 125129 102251 79516905
Intestinal villi atrophy 11.82 10.32 8 125224 461 79618695
Pulmonary thrombosis 11.80 10.32 44 125188 12127 79607029
Colorectal cancer metastatic 11.79 10.32 12 125220 1226 79617930
Abdominal abscess 11.78 10.32 31 125201 7096 79612060
Arteriosclerosis 11.77 10.32 7 125225 18220 79600936
Hyponatraemia 11.74 10.32 364 124868 177484 79441672
Drug delivery device placement 11.68 10.32 6 125226 206 79618950
Product prescribing error 11.65 10.32 34 125198 44779 79574377
Rhinitis allergic 11.60 10.32 44 125188 12225 79606931
Systemic inflammatory response syndrome 11.58 10.32 42 125190 11423 79607733
Disturbance in attention 11.49 10.32 41 125191 50760 79568396
Erythema 11.47 10.32 265 124967 223025 79396131
Cholangitis 11.42 10.32 45 125187 12731 79606425
Dyschromatopsia 11.40 10.32 10 125222 847 79618309
Diplopia 11.40 10.32 22 125210 33444 79585712
Signet-ring cell carcinoma 11.37 10.32 3 125229 13 79619143
Fungal cystitis 11.37 10.32 3 125229 13 79619143
Inferior vena cava dilatation 11.26 10.32 10 125222 861 79618295
Lacrimation increased 11.24 10.32 67 125165 22410 79596746
Peripheral pulse decreased 11.22 10.32 4 125228 54 79619102
Blood sodium decreased 11.21 10.32 90 125142 33165 79585991
Joint injury 11.21 10.32 20 125212 31315 79587841
Biopsy intestine abnormal 11.19 10.32 3 125229 14 79619142
Hyperchlorhydria 11.14 10.32 15 125217 2064 79617092
Migraine 11.12 10.32 86 125146 87407 79531749
Cor pulmonale acute 11.07 10.32 9 125223 687 79618469
Visual impairment 11.04 10.32 92 125140 92039 79527117
Platelet count decreased 10.95 10.32 391 124841 194273 79424883
Eye infection fungal 10.95 10.32 8 125224 521 79618635
Fear 10.95 10.32 11 125221 21975 79597181
Paralysis recurrent laryngeal nerve 10.95 10.32 5 125227 132 79619024
Hypoaesthesia 10.93 10.32 207 125025 179145 79440011
Device issue 10.92 10.32 16 125216 27092 79592064
Myelosuppression 10.89 10.32 30 125202 40266 79578890
Panniculitis 10.82 10.32 3 125229 12368 79606788
Product storage error 10.81 10.32 6 125226 16220 79602936
Steatorrhoea 10.78 10.32 10 125222 911 79618245
Self-injurious ideation 10.77 10.32 20 125212 3618 79615538
Ureteric obstruction 10.77 10.32 17 125215 2699 79616457
Liver injury 10.72 10.32 49 125183 56565 79562591
Pancreatic failure 10.70 10.32 13 125219 1615 79617541
Anhedonia 10.68 10.32 5 125227 14893 79604263
Treatment noncompliance 10.65 10.32 44 125188 52224 79566932
Fracture pain 10.63 10.32 9 125223 727 79618429
Biliary obstruction 10.61 10.32 23 125209 4651 79614505
Rhinovirus infection 10.60 10.32 32 125200 7921 79611235
Autoimmune nephritis 10.60 10.32 9 125223 730 79618426
Glaucoma 10.59 10.32 60 125172 19701 79599455
Autoimmune arthritis 10.58 10.32 5 125227 143 79619013
Duodenitis 10.56 10.32 32 125200 7935 79611221
Paranoia 10.53 10.32 9 125223 19423 79599733
Nervousness 10.51 10.32 23 125209 33392 79585764
Biopsy 10.44 10.32 9 125223 745 79618411
Prostatic obstruction 10.43 10.32 4 125228 67 79619089
Mitral valve incompetence 10.43 10.32 18 125214 28547 79590609
Device difficult to use 10.38 10.32 4 125228 13381 79605775

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
ATC A07DA03 ALIMENTARY TRACT AND METABOLISM
ANTIDIARRHEALS, INTESTINAL ANTIINFLAMMATORY/ANTIINFECTIVE AGENTS
ANTIPROPULSIVES
Antipropulsives
ATC A07DA53 ALIMENTARY TRACT AND METABOLISM
ANTIDIARRHEALS, INTESTINAL ANTIINFLAMMATORY/ANTIINFECTIVE AGENTS
ANTIPROPULSIVES
Antipropulsives
FDA MoA N0000000174 Opioid Agonists
MeSH PA D000930 Antidiarrheals
MeSH PA D005765 Gastrointestinal Agents
CHEBI has role CHEBI:55322 mu-opioid agonists
CHEBI has role CHEBI:55323 antidiarrheal drug
CHEBI has role CHEBI:149553 anticoronaviral drug
FDA EPC N0000175690 Opioid Agonist

Drug Use | Suggest Off label Use Form| |View source of the data|

DiseaseRelationSNOMED_IDDOID
Traveler's diarrhea indication 11840006
Diarrhea indication 62315008
Diarrhea Secondary to Inflammatory Bowel Disease indication
Chemotherapy-Induced Diarrhea off-label use
Infectious diarrheal disease contraindication 19213003 DOID:13250
Paralytic ileus contraindication 55525008 DOID:8442
Hemorrhagic diarrhea contraindication 95545007
Disease of liver contraindication 235856003 DOID:409




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 7.78 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])		Mechanism
action		Bioact sourceMoA source
Mu-type opioid receptor GPCR AGONIST Ki 8.82 WOMBAT-PK CHEMBL
Sodium channel protein type 5 subunit alpha Ion channel IC50 6.62 CHEMBL
D(2) dopamine receptor GPCR Ki 5.24 CHEMBL
Glutamate receptor ionotropic, NMDA 2A Ion channel WOMBAT-PK
Sigma non-opioid intracellular receptor 1 Membrane receptor Ki 6.58 DRUG MATRIX
Sodium-dependent serotonin transporter Transporter Ki 5.93 DRUG MATRIX
5-hydroxytryptamine receptor 2B GPCR Ki 5.58 DRUG MATRIX
D(3) dopamine receptor GPCR Ki 6.34 DRUG MATRIX
Histamine H1 receptor GPCR IC50 5.70 WOMBAT-PK
Histamine H2 receptor GPCR Ki 5.52 DRUG MATRIX
Aldehyde oxidase Enzyme IC50 5 WOMBAT-PK
Voltage-dependent P/Q-type calcium channel subunit alpha-1A Ion channel WOMBAT-PK
Cytochrome P450 2D6 Enzyme IC50 5.70 DRUG MATRIX
D(4) dopamine receptor GPCR Ki 5.73 CHEMBL
Alpha-1D adrenergic receptor GPCR Ki 5.60 DRUG MATRIX
Kappa-type opioid receptor GPCR Ki 6.81 WOMBAT-PK
Calmodulin Cytosolic other WOMBAT-PK
Delta-type opioid receptor GPCR Ki 6.91 WOMBAT-PK
Somatostatin receptor type 5 GPCR Ki 5.35 WOMBAT-PK
Glutamate receptor ionotropic, NMDA 2B Ion channel WOMBAT-PK
Glutamate receptor ionotropic, NMDA 2C Ion channel WOMBAT-PK
Glutamate receptor ionotropic, NMDA 2D Ion channel WOMBAT-PK
Angiopoietin-1 receptor Kinase Kd 5.23 CHEMBL
Solute carrier family 22 member 1 Transporter IC50 4.63 CHEMBL
Cocaine esterase Enzyme IC50 5.39 CHEMBL
Sodium channel alpha subunits; brain (Types I, II, III) Ion channel IC50 6.57 CHEMBL
Menin Unclassified IC50 4.16 CHEMBL
Beta-2 adrenergic receptor GPCR Ki 5.69 DRUG MATRIX
Alpha-1B adrenergic receptor GPCR Ki 6.27 DRUG MATRIX
Membrane-associated progesterone receptor component 1 Membrane receptor Ki 6.07 DRUG MATRIX
Alpha-1A adrenergic receptor GPCR IC50 5.21 CHEMBL
Mu-type opioid receptor GPCR Ki 9.80 CHEMBL
Delta-type opioid receptor GPCR Ki 7.30 CHEMBL
Calmodulin Cytosolic other Kd 5.46 CHEMBL

External reference:

IDSource
4019804 VUID
N0000147893 NUI
D00729 KEGG_DRUG
34552-83-5 SECONDARY_CAS_RN
4019178 VANDF
4019804 VANDF
C0023992 UMLSCUI
CHEBI:6532 CHEBI
CHEMBL841 ChEMBL_ID
CHEMBL1707 ChEMBL_ID
D008139 MESH_DESCRIPTOR_UI
DB00836 DRUGBANK_ID
7215 IUPHAR_LIGAND_ID
3098 INN_ID
6X9OC3H4II UNII
3955 PUBCHEM_CID
151889 RXNORM
2069 MMSL
2336 MMSL
4992 MMSL
d01025 MMSL
001154 NDDF
004545 NDDF
116726003 SNOMEDCT_US
387040009 SNOMEDCT_US
57574005 SNOMEDCT_US

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
Loperamide Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 0093-0311 CAPSULE 2 mg ORAL ANDA 26 sections
good sense anti diarrheal anti gas HUMAN OTC DRUG LABEL 2 0113-0087 TABLET 2 mg ORAL ANDA 16 sections
Good Sense anti diarrheal HUMAN OTC DRUG LABEL 1 0113-0224 TABLET, FILM COATED 2 mg ORAL ANDA 16 sections
Good Sense anti diarrheal HUMAN OTC DRUG LABEL 1 0113-0224 TABLET, FILM COATED 2 mg ORAL ANDA 16 sections
Good Sense Anti Diarrheal Anti Gas HUMAN OTC DRUG LABEL 2 0113-1087 TABLET 2 mg ORAL ANDA 16 sections
Good Sense antidiarrheal HUMAN OTC DRUG LABEL 1 0113-1645 SOLUTION 1 mg ORAL ANDA 16 sections
anti diarrheal HUMAN OTC DRUG LABEL 1 0113-2224 TABLET, FILM COATED 2 mg ORAL ANDA 16 sections
injoy diarrhea relief HUMAN OTC DRUG LABEL 1 0113-6004 TABLET, FILM COATED 2 mg ORAL ANDA 16 sections
basic care loperamide hydrochloride and simethicone HUMAN OTC DRUG LABEL 2 0113-7119 TABLET 2 mg ORAL ANDA 16 sections
Basic Care loperamide hydrochloride HUMAN OTC DRUG LABEL 1 0113-7224 TABLET, FILM COATED 2 mg ORAL ANDA 16 sections
Anti-Diarrheal HUMAN OTC DRUG LABEL 1 0363-0375 TABLET 2 mg ORAL ANDA 16 sections
Anti-Diarrheal HUMAN OTC DRUG LABEL 1 0363-0375 TABLET 2 mg ORAL ANDA 16 sections
loperamide hydrochloride HUMAN OTC DRUG LABEL 1 0363-0645 SUSPENSION 1 mg ORAL ANDA 16 sections
anti diarrheal HUMAN OTC DRUG LABEL 1 0363-1010 TABLET, FILM COATED 2 mg ORAL ANDA 16 sections
anti diarrheal HUMAN OTC DRUG LABEL 1 0363-1010 TABLET, FILM COATED 2 mg ORAL ANDA 16 sections
Anti-Diarrheal HUMAN OTC DRUG LABEL 1 0363-1176 CAPSULE, LIQUID FILLED 2 mg ORAL NDA 17 sections
Anti-Diarrheal HUMAN OTC DRUG LABEL 1 0363-1176 CAPSULE, LIQUID FILLED 2 mg ORAL NDA 17 sections
Anti-Diarrheal HUMAN OTC DRUG LABEL 1 0363-1176 CAPSULE, LIQUID FILLED 2 mg ORAL NDA 17 sections
anti diarrheal and anti gas HUMAN OTC DRUG LABEL 2 0363-1830 TABLET 2 mg ORAL ANDA 16 sections
anti diarrheal and anti gas HUMAN OTC DRUG LABEL 2 0363-1830 TABLET 2 mg ORAL ANDA 16 sections
Anti Diarrheal HUMAN OTC DRUG LABEL 1 0363-2022 SOLUTION 1 mg ORAL ANDA 16 sections
Loperamide Hydrochloride and Simethicone Human OTC Drug Label 2 0363-9606 TABLET 2 mg ORAL ANDA 16 sections
Loperamide Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 0378-2100 CAPSULE 2 mg ORAL ANDA 29 sections
Loperamide Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 0378-2100 CAPSULE 2 mg ORAL ANDA 29 sections
Loperamide Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 0378-2100 CAPSULE 2 mg ORAL ANDA 29 sections
Antidiarrheal Relief HUMAN OTC DRUG LABEL 1 0498-1071 TABLET 2 mg ORAL ANDA 16 sections
Antidiarrheal Relief HUMAN OTC DRUG LABEL 1 0498-1071 TABLET 2 mg ORAL ANDA 16 sections
Loperamide Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 0615-0362 CAPSULE 2 mg ORAL ANDA 25 sections
Loperamide Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 0615-8087 CAPSULE 2 mg ORAL ANDA 29 sections
Loperamide Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 0615-8087 CAPSULE 2 mg ORAL ANDA 29 sections