Stem definition | Drug id | CAS RN |
---|---|---|
1599 | 53179-11-6 |
Dose | Unit | Route |
---|---|---|
10 | mg | O |
Property | Value | Reference |
---|---|---|
BDDCS (Biopharmaceutical Drug Disposition Classification System) | 3 | Benet LZ, Broccatelli F, Oprea TI |
S (Water solubility) | 1.40 mg/mL | Benet LZ, Broccatelli F, Oprea TI |
EoM (Fraction excreted unchanged in urine) | 0.50 % | Benet LZ, Broccatelli F, Oprea TI |
MRTD (Maximum Recommended Therapeutic Daily Dose) | 0.48 µM/kg/day | Contrera JF, Matthews EJ, Kruhlak NL, Benz RD |
BA (Bioavailability) | 40 % | Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H |
Date | Agency | Company | Orphan |
---|---|---|---|
Dec. 28, 1976 | FDA | MCNEIL CONS |
MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
---|---|---|---|---|---|---|
Diarrhoea | 1551.34 | 10.43 | 3088 | 77185 | 622458 | 52646335 |
Dehydration | 289.80 | 10.43 | 723 | 79550 | 167687 | 53101106 |
Rheumatoid arthritis | 205.05 | 10.43 | 109 | 80164 | 314422 | 52954371 |
Pneumonia viral | 183.25 | 10.43 | 121 | 80152 | 6991 | 53261802 |
Maternal exposure during pregnancy | 165.27 | 10.43 | 20 | 80253 | 155619 | 53113174 |
Drug ineffective | 151.16 | 10.43 | 676 | 79597 | 816569 | 52452224 |
Vomiting | 144.05 | 10.43 | 1255 | 79018 | 495884 | 52772909 |
Pneumonia aspiration | 132.28 | 10.43 | 207 | 80066 | 34094 | 53234699 |
Drug abuse | 131.56 | 10.43 | 299 | 79974 | 65227 | 53203566 |
Systemic lupus erythematosus | 126.27 | 10.43 | 19 | 80254 | 125395 | 53143398 |
Torsade de pointes | 122.74 | 10.43 | 123 | 80150 | 12882 | 53255911 |
Hypokalaemia | 121.57 | 10.43 | 370 | 79903 | 96147 | 53172646 |
Soft tissue disorder | 115.43 | 10.43 | 75 | 80198 | 4215 | 53264578 |
Ventricular tachycardia | 113.71 | 10.43 | 137 | 80136 | 17625 | 53251168 |
Decreased appetite | 112.69 | 10.43 | 628 | 79645 | 214346 | 53054447 |
Coma | 102.61 | 10.43 | 262 | 80011 | 61521 | 53207272 |
Pain | 98.88 | 10.43 | 503 | 79770 | 587895 | 52680898 |
Hypomagnesaemia | 97.42 | 10.43 | 151 | 80122 | 24660 | 53244133 |
Electrocardiogram QT prolonged | 96.60 | 10.43 | 242 | 80031 | 56161 | 53212632 |
Gastrooesophageal reflux disease | 95.87 | 10.43 | 308 | 79965 | 82355 | 53186438 |
Colitis | 95.20 | 10.43 | 200 | 80073 | 41352 | 53227441 |
Oral pain | 91.27 | 10.43 | 153 | 80120 | 26684 | 53242109 |
Abdominal pain | 89.48 | 10.43 | 675 | 79598 | 255228 | 53013565 |
Hypomania | 88.48 | 10.43 | 67 | 80206 | 4815 | 53263978 |
Contraindicated product administered | 85.32 | 10.43 | 49 | 80224 | 135580 | 53133213 |
Jaundice cholestatic | 85.26 | 10.43 | 69 | 80204 | 5465 | 53263328 |
Nausea | 85.00 | 10.43 | 1601 | 78672 | 754490 | 52514303 |
Glossodynia | 84.74 | 10.43 | 23 | 80250 | 100268 | 53168525 |
Gastrointestinal stoma complication | 79.14 | 10.43 | 42 | 80231 | 1614 | 53267179 |
Small intestinal obstruction | 78.27 | 10.43 | 112 | 80161 | 17035 | 53251758 |
Pericarditis | 69.01 | 10.43 | 8 | 80265 | 64398 | 53204395 |
Intestinal obstruction | 68.95 | 10.43 | 141 | 80132 | 28600 | 53240193 |
Completed suicide | 65.19 | 10.43 | 67 | 80206 | 138134 | 53130659 |
Drug hypersensitivity | 63.98 | 10.43 | 196 | 80077 | 265046 | 53003747 |
Neuropathy peripheral | 63.27 | 10.43 | 315 | 79958 | 102872 | 53165921 |
Exposure during pregnancy | 63.00 | 10.43 | 57 | 80216 | 124803 | 53143990 |
Drug intolerance | 61.69 | 10.43 | 136 | 80137 | 205357 | 53063436 |
Arthropathy | 59.73 | 10.43 | 75 | 80198 | 141378 | 53127415 |
Blood magnesium increased | 59.59 | 10.43 | 44 | 80229 | 3043 | 53265750 |
Schizophrenia | 58.90 | 10.43 | 75 | 80198 | 10204 | 53258589 |
Presbyacusis | 58.55 | 10.43 | 43 | 80230 | 2949 | 53265844 |
Infusion related reaction | 58.54 | 10.43 | 90 | 80183 | 155867 | 53112926 |
Pleural thickening | 55.93 | 10.43 | 40 | 80233 | 2632 | 53266161 |
Mucosal inflammation | 54.74 | 10.43 | 165 | 80108 | 42619 | 53226174 |
Neutropenic sepsis | 54.52 | 10.43 | 87 | 80186 | 14562 | 53254231 |
Colitis microscopic | 54.28 | 10.43 | 60 | 80213 | 7034 | 53261759 |
Discomfort | 53.87 | 10.43 | 39 | 80234 | 95433 | 53173360 |
Somnolence | 52.77 | 10.43 | 432 | 79841 | 167302 | 53101491 |
Deafness neurosensory | 52.24 | 10.43 | 49 | 80224 | 4729 | 53264064 |
Weight decreased | 51.85 | 10.43 | 561 | 79712 | 234387 | 53034406 |
Intentional overdose | 51.44 | 10.43 | 219 | 80054 | 66986 | 53201807 |
Pleural fibrosis | 51.43 | 10.43 | 43 | 80230 | 3565 | 53265228 |
Blood magnesium decreased | 49.34 | 10.43 | 74 | 80199 | 11740 | 53257053 |
Lethargy | 49 | 10.43 | 185 | 80088 | 53575 | 53215218 |
Constipation | 48.61 | 10.43 | 484 | 79789 | 197928 | 53070865 |
Therapeutic product effect decreased | 47.64 | 10.43 | 72 | 80201 | 125583 | 53143210 |
Brain stem glioma | 46.59 | 10.43 | 15 | 80258 | 152 | 53268641 |
Wound | 45.93 | 10.43 | 42 | 80231 | 91515 | 53177278 |
Febrile neutropenia | 44.92 | 10.43 | 291 | 79982 | 104645 | 53164148 |
Psoriatic arthropathy | 44.76 | 10.43 | 9 | 80264 | 48181 | 53220612 |
Segmental diverticular colitis | 43.74 | 10.43 | 14 | 80259 | 139 | 53268654 |
Respiration abnormal | 42.79 | 10.43 | 47 | 80226 | 5471 | 53263322 |
Pedal pulse abnormal | 42.79 | 10.43 | 14 | 80259 | 150 | 53268643 |
Swelling | 42.72 | 10.43 | 146 | 80127 | 190959 | 53077834 |
Calcium ionised decreased | 42.67 | 10.43 | 16 | 80257 | 263 | 53268530 |
Injection site pain | 42 | 10.43 | 66 | 80207 | 113325 | 53155468 |
Injection site erythema | 41.73 | 10.43 | 33 | 80240 | 77216 | 53191577 |
Malignant neoplasm progression | 41.45 | 10.43 | 215 | 80058 | 71326 | 53197467 |
Psoriasis | 41.30 | 10.43 | 42 | 80231 | 87047 | 53181746 |
Flatulence | 40.74 | 10.43 | 122 | 80151 | 31395 | 53237398 |
Injection site pruritus | 40.26 | 10.43 | 7 | 80266 | 41582 | 53227211 |
Electrocardiogram QRS complex prolonged | 39.57 | 10.43 | 46 | 80227 | 5696 | 53263097 |
Nail dystrophy | 39.53 | 10.43 | 20 | 80253 | 695 | 53268098 |
Helicobacter infection | 39.11 | 10.43 | 6 | 80267 | 39063 | 53229730 |
Knee arthroplasty | 39.05 | 10.43 | 3 | 80270 | 33566 | 53235227 |
Arthralgia | 38.88 | 10.43 | 449 | 79824 | 439334 | 52829459 |
Headache | 38.00 | 10.43 | 574 | 79699 | 536247 | 52732546 |
Clostridium difficile infection | 37.99 | 10.43 | 110 | 80163 | 27783 | 53241010 |
Epigastric discomfort | 36.89 | 10.43 | 46 | 80227 | 6127 | 53262666 |
Accidental overdose | 36.59 | 10.43 | 92 | 80181 | 21387 | 53247406 |
Long QT syndrome | 36.42 | 10.43 | 34 | 80239 | 3262 | 53265531 |
Device related infection | 36.13 | 10.43 | 95 | 80178 | 22691 | 53246102 |
Treatment failure | 36.07 | 10.43 | 88 | 80185 | 128315 | 53140478 |
Total lung capacity increased | 35.48 | 10.43 | 20 | 80253 | 867 | 53267926 |
Herpes zoster | 35.26 | 10.43 | 211 | 80062 | 73808 | 53194985 |
Pouchitis | 34.65 | 10.43 | 16 | 80257 | 453 | 53268340 |
Blood potassium decreased | 34.23 | 10.43 | 136 | 80137 | 40324 | 53228469 |
Sinusitis | 34.22 | 10.43 | 134 | 80139 | 168430 | 53100363 |
Device expulsion | 33.76 | 10.43 | 3 | 80270 | 29810 | 53238983 |
Appetite disorder | 33.24 | 10.43 | 45 | 80228 | 6498 | 53262295 |
Pneumonia | 33.14 | 10.43 | 824 | 79449 | 406345 | 52862448 |
Brugada syndrome | 33.08 | 10.43 | 14 | 80259 | 320 | 53268473 |
Blood bilirubin increased | 32.59 | 10.43 | 123 | 80150 | 35607 | 53233186 |
Gallbladder polyp | 32.47 | 10.43 | 18 | 80255 | 755 | 53268038 |
Drug interaction | 31.49 | 10.43 | 197 | 80076 | 219132 | 53049661 |
Red blood cell sedimentation rate increased | 31.29 | 10.43 | 3 | 80270 | 28054 | 53240739 |
Cholelithiasis | 30.96 | 10.43 | 133 | 80140 | 40831 | 53227962 |
Arteriovenous fistula occlusion | 30.89 | 10.43 | 14 | 80259 | 379 | 53268414 |
Disease progression | 30.69 | 10.43 | 260 | 80013 | 101660 | 53167133 |
Joint swelling | 30.55 | 10.43 | 217 | 80056 | 234421 | 53034372 |
Frequent bowel movements | 30.28 | 10.43 | 67 | 80206 | 14345 | 53254448 |
Injection site reaction | 30.05 | 10.43 | 20 | 80253 | 51146 | 53217647 |
Blue toe syndrome | 29.91 | 10.43 | 14 | 80259 | 409 | 53268384 |
Post procedural diarrhoea | 29.78 | 10.43 | 11 | 80262 | 173 | 53268620 |
Stoma complication | 29.76 | 10.43 | 13 | 80260 | 322 | 53268471 |
Hypersensitivity | 29.33 | 10.43 | 191 | 80082 | 210474 | 53058319 |
Injection site bruising | 29.32 | 10.43 | 10 | 80263 | 37636 | 53231157 |
Syncope | 28.76 | 10.43 | 276 | 79997 | 111717 | 53157076 |
Hip arthroplasty | 28.53 | 10.43 | 4 | 80269 | 27858 | 53240935 |
Wrong technique in product usage process | 28.40 | 10.43 | 29 | 80244 | 60003 | 53208790 |
Dry skin | 28.24 | 10.43 | 140 | 80133 | 45620 | 53223173 |
Intentional self-injury | 28.19 | 10.43 | 93 | 80180 | 25191 | 53243602 |
Impaired healing | 28.19 | 10.43 | 33 | 80240 | 64172 | 53204621 |
Ventricular arrhythmia | 28.08 | 10.43 | 31 | 80242 | 3629 | 53265164 |
Conduction disorder | 27.95 | 10.43 | 21 | 80252 | 1491 | 53267302 |
Drug use disorder | 27.75 | 10.43 | 29 | 80244 | 3190 | 53265603 |
Rhinorrhoea | 27.64 | 10.43 | 156 | 80117 | 53422 | 53215371 |
Liver function test abnormal | 27.52 | 10.43 | 144 | 80129 | 47927 | 53220866 |
Therapeutic response decreased | 27.39 | 10.43 | 19 | 80254 | 47550 | 53221243 |
Gastroenteritis radiation | 27.27 | 10.43 | 14 | 80259 | 502 | 53268291 |
Heart sounds | 26.79 | 10.43 | 14 | 80259 | 521 | 53268272 |
Feeding intolerance | 26.64 | 10.43 | 14 | 80259 | 527 | 53268266 |
Brain injury | 26.57 | 10.43 | 40 | 80233 | 6365 | 53262428 |
No adverse event | 26.41 | 10.43 | 13 | 80260 | 39252 | 53229541 |
Weight increased | 26.23 | 10.43 | 190 | 80083 | 204377 | 53064416 |
Premature delivery | 26.15 | 10.43 | 4 | 80269 | 26100 | 53242693 |
Therapeutic reaction time decreased | 25.55 | 10.43 | 19 | 80254 | 1328 | 53267465 |
Folliculitis | 25.44 | 10.43 | 8 | 80265 | 31701 | 53237092 |
Bile acid malabsorption | 25.14 | 10.43 | 10 | 80263 | 194 | 53268599 |
Urticaria | 25.11 | 10.43 | 112 | 80161 | 135773 | 53133020 |
Clostridium difficile colitis | 25.06 | 10.43 | 76 | 80197 | 19689 | 53249104 |
Anal abscess | 24.65 | 10.43 | 30 | 80243 | 3898 | 53264895 |
Gastrointestinal stoma output increased | 24.64 | 10.43 | 10 | 80263 | 205 | 53268588 |
Pulmonary embolism | 24.61 | 10.43 | 272 | 80001 | 114170 | 53154623 |
Mydriasis | 24.19 | 10.43 | 53 | 80220 | 11273 | 53257520 |
Thymus disorder | 24.11 | 10.43 | 10 | 80263 | 217 | 53268576 |
Foetal exposure during pregnancy | 24.11 | 10.43 | 11 | 80262 | 34704 | 53234089 |
Unresponsive to stimuli | 24.09 | 10.43 | 107 | 80166 | 33319 | 53235474 |
Fatigue | 24.01 | 10.43 | 1335 | 78938 | 729171 | 52539622 |
Product quality issue | 23.80 | 10.43 | 13 | 80260 | 37010 | 53231783 |
Crohn's disease | 23.63 | 10.43 | 39 | 80234 | 6711 | 53262082 |
Overdose | 23.59 | 10.43 | 257 | 80016 | 107479 | 53161314 |
Skin fissures | 23.50 | 10.43 | 45 | 80228 | 8700 | 53260093 |
Stomatitis | 23.30 | 10.43 | 238 | 80035 | 97920 | 53170873 |
Injection site swelling | 23.28 | 10.43 | 18 | 80255 | 42610 | 53226183 |
Ill-defined disorder | 23.26 | 10.43 | 24 | 80249 | 49420 | 53219373 |
Multiple sclerosis relapse | 23.18 | 10.43 | 20 | 80253 | 44833 | 53223960 |
Pneumonitis | 23.12 | 10.43 | 100 | 80173 | 30788 | 53238005 |
Hypophagia | 22.82 | 10.43 | 100 | 80173 | 30962 | 53237831 |
Anaemia | 22.76 | 10.43 | 561 | 79712 | 276157 | 52992636 |
Off label use | 22.51 | 10.43 | 540 | 79733 | 471672 | 52797121 |
Leukopenia | 22.42 | 10.43 | 188 | 80085 | 73275 | 53195518 |
Pulmonary thrombosis | 22.38 | 10.43 | 42 | 80231 | 7999 | 53260794 |
Pyrexia | 22.12 | 10.43 | 777 | 79496 | 402416 | 52866377 |
Prolonged expiration | 21.95 | 10.43 | 13 | 80260 | 619 | 53268174 |
Vascular device infection | 21.84 | 10.43 | 30 | 80243 | 4391 | 53264402 |
Ear infection | 21.75 | 10.43 | 6 | 80267 | 25894 | 53242899 |
Musculoskeletal stiffness | 21.42 | 10.43 | 104 | 80169 | 123264 | 53145529 |
Abdominal discomfort | 21.35 | 10.43 | 221 | 80052 | 220841 | 53047952 |
Sedation | 21.24 | 10.43 | 9 | 80264 | 29666 | 53239127 |
Coronary artery disease | 21.12 | 10.43 | 12 | 80261 | 33425 | 53235368 |
Blood creatinine increased | 20.86 | 10.43 | 203 | 80070 | 82459 | 53186334 |
Loss of personal independence in daily activities | 20.27 | 10.43 | 47 | 80226 | 69768 | 53199025 |
Palmar-plantar erythrodysaesthesia syndrome | 20.22 | 10.43 | 75 | 80198 | 21531 | 53247262 |
Cardiotoxicity | 20.16 | 10.43 | 38 | 80235 | 7261 | 53261532 |
Dermatitis acneiform | 20.11 | 10.43 | 29 | 80244 | 4441 | 53264352 |
Short-bowel syndrome | 20.07 | 10.43 | 11 | 80262 | 451 | 53268342 |
Femur fracture | 20.03 | 10.43 | 18 | 80255 | 39567 | 53229226 |
Rash | 19.97 | 10.43 | 515 | 79758 | 445676 | 52823117 |
Large intestine polyp | 19.74 | 10.43 | 40 | 80233 | 8057 | 53260736 |
Enteritis | 19.62 | 10.43 | 38 | 80235 | 7408 | 53261385 |
Therapeutic product effect incomplete | 19.24 | 10.43 | 72 | 80201 | 91712 | 53177081 |
Hepatotoxicity | 19.16 | 10.43 | 88 | 80185 | 27792 | 53241001 |
Type 2 diabetes mellitus | 19.11 | 10.43 | 12 | 80261 | 31658 | 53237135 |
Paronychia | 19.09 | 10.43 | 30 | 80243 | 4954 | 53263839 |
Food interaction | 19.01 | 10.43 | 12 | 80261 | 641 | 53268152 |
Bone hypertrophy | 18.99 | 10.43 | 10 | 80263 | 378 | 53268415 |
Product dose omission issue | 18.73 | 10.43 | 191 | 80082 | 191429 | 53077364 |
Enterocolitis | 18.59 | 10.43 | 36 | 80237 | 7016 | 53261777 |
Gastroenteritis | 18.46 | 10.43 | 82 | 80191 | 25534 | 53243259 |
Dyspepsia | 18.34 | 10.43 | 188 | 80085 | 77412 | 53191381 |
Tenderness | 18.05 | 10.43 | 68 | 80205 | 19662 | 53249131 |
Dry eye | 18.04 | 10.43 | 99 | 80174 | 33545 | 53235248 |
Drug resistance | 17.98 | 10.43 | 4 | 80269 | 19958 | 53248835 |
Neutropenia | 17.65 | 10.43 | 337 | 79936 | 158848 | 53109945 |
Pancreatitis chronic | 17.64 | 10.43 | 20 | 80253 | 2410 | 53266383 |
Congenital knee deformity | 17.54 | 10.43 | 5 | 80268 | 32 | 53268761 |
Pregnancy | 17.52 | 10.43 | 13 | 80260 | 31428 | 53237365 |
Intestinal fibrosis | 17.40 | 10.43 | 7 | 80266 | 140 | 53268653 |
Anal incontinence | 17.34 | 10.43 | 50 | 80223 | 12597 | 53256196 |
Ileal stenosis | 17.27 | 10.43 | 16 | 80257 | 1520 | 53267273 |
Reflux gastritis | 17.25 | 10.43 | 13 | 80260 | 927 | 53267866 |
Accidental exposure to product | 17.24 | 10.43 | 7 | 80266 | 23667 | 53245126 |
Alopecia | 17.15 | 10.43 | 249 | 80024 | 234334 | 53034459 |
Autoimmune nephritis | 17.15 | 10.43 | 9 | 80264 | 338 | 53268455 |
Hypovolaemia | 17.14 | 10.43 | 44 | 80229 | 10358 | 53258435 |
Peripheral pulse decreased | 17.04 | 10.43 | 5 | 80268 | 36 | 53268757 |
Proctitis | 17.02 | 10.43 | 18 | 80255 | 2007 | 53266786 |
Ejection fraction decreased | 17.01 | 10.43 | 67 | 80206 | 19781 | 53249012 |
Urinary tract infection | 17.00 | 10.43 | 477 | 79796 | 239426 | 53029367 |
Sinus arrest | 16.59 | 10.43 | 17 | 80256 | 1827 | 53266966 |
Long QT syndrome congenital | 16.58 | 10.43 | 5 | 80268 | 40 | 53268753 |
Sepsis | 16.57 | 10.43 | 311 | 79962 | 146118 | 53122675 |
Hypermagnesaemia | 16.48 | 10.43 | 13 | 80260 | 992 | 53267801 |
Inflammatory bowel disease | 16.28 | 10.43 | 24 | 80249 | 3749 | 53265044 |
Cor pulmonale acute | 16.27 | 10.43 | 9 | 80264 | 376 | 53268417 |
Plantar erythema | 16.19 | 10.43 | 8 | 80265 | 264 | 53268529 |
Hypocalcaemia | 16.18 | 10.43 | 87 | 80186 | 29250 | 53239543 |
Bone cyst | 16.10 | 10.43 | 18 | 80255 | 2136 | 53266657 |
Synovitis | 15.94 | 10.43 | 96 | 80177 | 107797 | 53160996 |
Fracture pain | 15.91 | 10.43 | 9 | 80264 | 393 | 53268400 |
Drug eruption | 15.86 | 10.43 | 9 | 80264 | 25085 | 53243708 |
Stoma site ulcer | 15.84 | 10.43 | 8 | 80265 | 277 | 53268516 |
Condition aggravated | 15.77 | 10.43 | 334 | 79939 | 296800 | 52971993 |
Cyst | 15.77 | 10.43 | 49 | 80224 | 12862 | 53255931 |
Gastrointestinal sounds abnormal | 15.75 | 10.43 | 24 | 80249 | 3860 | 53264933 |
Abortion spontaneous | 15.56 | 10.43 | 29 | 80244 | 46606 | 53222187 |
Enterocutaneous fistula | 15.47 | 10.43 | 14 | 80259 | 1290 | 53267503 |
Asthenia | 15.46 | 10.43 | 648 | 79625 | 342942 | 52925851 |
Rectal abscess | 15.41 | 10.43 | 13 | 80260 | 1091 | 53267702 |
Dysgeusia | 15.37 | 10.43 | 114 | 80159 | 42817 | 53225976 |
Influenza like illness | 15.34 | 10.43 | 44 | 80229 | 60815 | 53207978 |
Intestinal anastomosis | 15.33 | 10.43 | 8 | 80265 | 297 | 53268496 |
Failure to thrive | 15.25 | 10.43 | 33 | 80240 | 6959 | 53261834 |
Paralysis recurrent laryngeal nerve | 15.24 | 10.43 | 5 | 80268 | 54 | 53268739 |
Malnutrition | 15.08 | 10.43 | 53 | 80220 | 14818 | 53253975 |
Food refusal | 14.92 | 10.43 | 8 | 80265 | 314 | 53268479 |
Tachycardia | 14.83 | 10.43 | 237 | 80036 | 107975 | 53160818 |
Ileostomy | 14.82 | 10.43 | 13 | 80260 | 1150 | 53267643 |
Biliary sepsis | 14.81 | 10.43 | 12 | 80261 | 952 | 53267841 |
Electrolyte imbalance | 14.80 | 10.43 | 62 | 80211 | 18822 | 53249971 |
Peritoneal perforation | 14.74 | 10.43 | 6 | 80267 | 124 | 53268669 |
Palmar erythema | 14.66 | 10.43 | 15 | 80258 | 1609 | 53267184 |
Nail disorder | 14.65 | 10.43 | 40 | 80233 | 9765 | 53259028 |
Intestinal perforation | 14.65 | 10.43 | 44 | 80229 | 11336 | 53257457 |
Arthritis | 14.64 | 10.43 | 198 | 80075 | 87100 | 53181693 |
Pruritus | 14.53 | 10.43 | 334 | 79939 | 293498 | 52975295 |
Amoebic colitis | 14.43 | 10.43 | 3 | 80270 | 3 | 53268790 |
Catheter site bruise | 14.40 | 10.43 | 8 | 80265 | 337 | 53268456 |
Small intestine ulcer | 14.21 | 10.43 | 8 | 80265 | 346 | 53268447 |
Hepatic lesion | 14.19 | 10.43 | 24 | 80249 | 4213 | 53264580 |
Unmasking of previously unidentified disease | 14.12 | 10.43 | 11 | 80262 | 824 | 53267969 |
Ileus | 14.06 | 10.43 | 52 | 80221 | 14903 | 53253890 |
Onychalgia | 13.83 | 10.43 | 11 | 80262 | 850 | 53267943 |
Blood potassium increased | 13.53 | 10.43 | 58 | 80215 | 17783 | 53251010 |
Hepatic enzyme increased | 13.50 | 10.43 | 123 | 80150 | 126072 | 53142721 |
Gluten sensitivity | 13.40 | 10.43 | 9 | 80264 | 535 | 53268258 |
Amputation | 13.32 | 10.43 | 6 | 80267 | 160 | 53268633 |
Peritoneal disorder | 13.26 | 10.43 | 9 | 80264 | 544 | 53268249 |
Rectal haemorrhage | 13.10 | 10.43 | 107 | 80166 | 41374 | 53227419 |
Product use in unapproved indication | 13.10 | 10.43 | 107 | 80166 | 112182 | 53156611 |
Tumour inflammation | 13.05 | 10.43 | 4 | 80269 | 34 | 53268759 |
Pleural effusion | 12.89 | 10.43 | 196 | 80077 | 88383 | 53180410 |
Periventricular leukomalacia | 12.87 | 10.43 | 5 | 80268 | 91 | 53268702 |
Acute kidney injury | 12.85 | 10.43 | 485 | 79788 | 253383 | 53015410 |
Nail bed tenderness | 12.84 | 10.43 | 7 | 80266 | 284 | 53268509 |
Ataxia | 12.83 | 10.43 | 50 | 80223 | 14687 | 53254106 |
Ureteric obstruction | 12.81 | 10.43 | 15 | 80258 | 1871 | 53266922 |
Hyperchlorhydria | 12.73 | 10.43 | 14 | 80259 | 1632 | 53267161 |
Osteopenia | 12.66 | 10.43 | 58 | 80215 | 18297 | 53250496 |
Eye irritation | 12.57 | 10.43 | 6 | 80267 | 18443 | 53250350 |
Psychotic disorder | 12.57 | 10.43 | 71 | 80202 | 24314 | 53244479 |
Road traffic accident | 12.56 | 10.43 | 12 | 80261 | 25619 | 53243174 |
Cerebral haemorrhage | 12.55 | 10.43 | 16 | 80257 | 29980 | 53238813 |
Accidental exposure to product by child | 12.47 | 10.43 | 12 | 80261 | 1196 | 53267597 |
Adverse event | 12.44 | 10.43 | 27 | 80246 | 41034 | 53227759 |
Autonomic neuropathy | 12.31 | 10.43 | 11 | 80262 | 997 | 53267796 |
Megacolon | 12.31 | 10.43 | 15 | 80258 | 1951 | 53266842 |
Foetal arrhythmia | 12.29 | 10.43 | 6 | 80267 | 193 | 53268600 |
Anaemia of malignant disease | 12.26 | 10.43 | 8 | 80265 | 453 | 53268340 |
Defaecation urgency | 12.22 | 10.43 | 19 | 80254 | 3109 | 53265684 |
Device issue | 12.01 | 10.43 | 9 | 80264 | 21649 | 53247144 |
Blood cholesterol increased | 11.87 | 10.43 | 127 | 80146 | 52862 | 53215931 |
Cardiorenal syndrome | 11.84 | 10.43 | 9 | 80264 | 650 | 53268143 |
Piloerection | 11.79 | 10.43 | 7 | 80266 | 335 | 53268458 |
Autoimmune colitis | 11.72 | 10.43 | 8 | 80265 | 488 | 53268305 |
Suicidal ideation | 11.70 | 10.43 | 49 | 80224 | 60462 | 53208331 |
Pharyngo-oesophageal diverticulum | 11.69 | 10.43 | 3 | 80270 | 12 | 53268781 |
Platelet count decreased | 11.68 | 10.43 | 228 | 80045 | 107871 | 53160922 |
Ventricular fibrillation | 11.67 | 10.43 | 42 | 80231 | 11883 | 53256910 |
Anxiety | 11.66 | 10.43 | 217 | 80056 | 196487 | 53072306 |
Accidental poisoning | 11.63 | 10.43 | 9 | 80264 | 668 | 53268125 |
Motion sickness | 11.61 | 10.43 | 10 | 80263 | 863 | 53267930 |
Alveolar bone resorption | 11.60 | 10.43 | 4 | 80269 | 51 | 53268742 |
Renal pain | 11.53 | 10.43 | 27 | 80246 | 6000 | 53262793 |
Fibromyalgia | 11.49 | 10.43 | 109 | 80164 | 43966 | 53224827 |
Abdominal mass | 11.39 | 10.43 | 17 | 80256 | 2685 | 53266108 |
Joint effusion | 11.39 | 10.43 | 3 | 80270 | 13349 | 53255444 |
Moraxella infection | 11.33 | 10.43 | 7 | 80266 | 360 | 53268433 |
Hypophosphataemia | 11.30 | 10.43 | 34 | 80239 | 8771 | 53260022 |
Large intestine perforation | 11.29 | 10.43 | 32 | 80241 | 7982 | 53260811 |
Hip fracture | 11.25 | 10.43 | 77 | 80196 | 28180 | 53240613 |
Gastroenteropancreatic neuroendocrine tumour disease | 11.19 | 10.43 | 4 | 80269 | 57 | 53268736 |
Glaucoma | 11.19 | 10.43 | 53 | 80220 | 16950 | 53251843 |
Neutrophil count decreased | 11.15 | 10.43 | 118 | 80155 | 48980 | 53219813 |
Blood sodium decreased | 11.07 | 10.43 | 66 | 80207 | 23050 | 53245743 |
Lip erosion | 11.00 | 10.43 | 10 | 80263 | 927 | 53267866 |
Intentional product use issue | 10.97 | 10.43 | 64 | 80209 | 72430 | 53196363 |
Osteosclerosis | 10.92 | 10.43 | 20 | 80253 | 3738 | 53265055 |
Miosis | 10.90 | 10.43 | 29 | 80244 | 6973 | 53261820 |
Soft tissue swelling | 10.80 | 10.43 | 10 | 80263 | 949 | 53267844 |
Abdominal pain upper | 10.77 | 10.43 | 327 | 79946 | 165964 | 53102829 |
Abdominal distension | 10.64 | 10.43 | 174 | 80099 | 79616 | 53189177 |
Cardiac arrest | 10.61 | 10.43 | 199 | 80074 | 93468 | 53175325 |
Obesity | 10.49 | 10.43 | 6 | 80267 | 16656 | 53252137 |
MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
---|---|---|---|---|---|---|
Diarrhoea | 1102.01 | 11.19 | 2026 | 49903 | 362776 | 32098821 |
Drug abuse | 277.91 | 11.19 | 476 | 51453 | 79767 | 32381830 |
Torsade de pointes | 222.75 | 11.19 | 142 | 51787 | 7273 | 32454324 |
Dehydration | 198.32 | 11.19 | 551 | 51378 | 128407 | 32333190 |
Electrocardiogram QRS complex prolonged | 187.61 | 11.19 | 107 | 51822 | 4467 | 32457130 |
Electrocardiogram QT prolonged | 179.53 | 11.19 | 266 | 51663 | 39375 | 32422222 |
Intentional overdose | 154.74 | 11.19 | 255 | 51674 | 41346 | 32420251 |
Colitis | 130.15 | 11.19 | 211 | 51718 | 33740 | 32427857 |
Ventricular tachycardia | 107.85 | 11.19 | 166 | 51763 | 25390 | 32436207 |
Abdominal pain | 94.46 | 11.19 | 480 | 51449 | 149049 | 32312548 |
Drug ineffective | 70.15 | 11.19 | 345 | 51584 | 383132 | 32078465 |
Small intestinal obstruction | 65.27 | 11.19 | 96 | 51833 | 14100 | 32447497 |
Intestinal obstruction | 63.60 | 11.19 | 117 | 51812 | 20681 | 32440916 |
Intentional self-injury | 62.47 | 11.19 | 93 | 51836 | 13807 | 32447790 |
Brugada syndrome | 62.36 | 11.19 | 28 | 51901 | 697 | 32460900 |
Vomiting | 59.62 | 11.19 | 606 | 51323 | 234951 | 32226646 |
Blood mercury abnormal | 58.31 | 11.19 | 19 | 51910 | 188 | 32461409 |
Conduction disorder | 57.01 | 11.19 | 37 | 51892 | 1953 | 32459644 |
5-hydroxyindolacetic acid in urine increased | 56.18 | 11.19 | 19 | 51910 | 213 | 32461384 |
Decreased appetite | 53.48 | 11.19 | 439 | 51490 | 160374 | 32301223 |
Drug use disorder | 51.08 | 11.19 | 44 | 51885 | 3577 | 32458020 |
Completed suicide | 50.57 | 11.19 | 44 | 51885 | 92473 | 32369124 |
Overdose | 48.36 | 11.19 | 270 | 51659 | 86807 | 32374790 |
Rheumatoid arthritis | 47.95 | 11.19 | 7 | 51922 | 44537 | 32417060 |
Foetal exposure during pregnancy | 43.30 | 11.19 | 7 | 51922 | 41294 | 32420303 |
Pouchitis | 39.16 | 11.19 | 20 | 51909 | 667 | 32460930 |
Nausea | 39.09 | 11.19 | 724 | 51205 | 320125 | 32141472 |
Electrolyte imbalance | 37.96 | 11.19 | 70 | 51859 | 12392 | 32449205 |
Abscess intestinal | 36.29 | 11.19 | 25 | 51904 | 1458 | 32460139 |
Respiratory depression | 36.28 | 11.19 | 71 | 51858 | 13140 | 32448457 |
Alveolar lung disease | 35.35 | 11.19 | 16 | 51913 | 406 | 32461191 |
Fatigue | 34.00 | 11.19 | 765 | 51164 | 349936 | 32111661 |
Ileus | 33.76 | 11.19 | 78 | 51851 | 16187 | 32445410 |
Product use in unapproved indication | 30.53 | 11.19 | 58 | 51871 | 87146 | 32374451 |
Pulmonary interstitial emphysema syndrome | 29.97 | 11.19 | 15 | 51914 | 479 | 32461118 |
Myocardial infarction | 29.77 | 11.19 | 102 | 51827 | 125574 | 32336023 |
Abdominal distension | 29.76 | 11.19 | 161 | 51768 | 51134 | 32410463 |
Hypomagnesaemia | 29.42 | 11.19 | 81 | 51848 | 18724 | 32442873 |
Drug hypersensitivity | 29.19 | 11.19 | 45 | 51884 | 73355 | 32388242 |
Weight decreased | 29.12 | 11.19 | 396 | 51533 | 164422 | 32297175 |
Low density lipoprotein decreased | 28.75 | 11.19 | 19 | 51910 | 1034 | 32460563 |
Psoriasis | 27.62 | 11.19 | 20 | 51909 | 46103 | 32415494 |
Hepatic neoplasm | 26.81 | 11.19 | 24 | 51905 | 2054 | 32459543 |
Gastrointestinal stoma complication | 26.68 | 11.19 | 20 | 51909 | 1332 | 32460265 |
Cardiotoxicity | 26.59 | 11.19 | 36 | 51893 | 4896 | 32456701 |
Cardiac arrest | 26.33 | 11.19 | 253 | 51676 | 96523 | 32365074 |
Enteritis | 26.28 | 11.19 | 44 | 51885 | 7217 | 32454380 |
Treatment failure | 26.15 | 11.19 | 15 | 51914 | 39148 | 32422449 |
Ventricular arrhythmia | 25.77 | 11.19 | 36 | 51893 | 5043 | 32456554 |
Crohn's disease | 25.40 | 11.19 | 33 | 51896 | 4312 | 32457285 |
Asthma | 25.24 | 11.19 | 20 | 51909 | 44045 | 32417552 |
Accidental overdose | 25.17 | 11.19 | 78 | 51851 | 19261 | 32442336 |
Intentional product misuse | 25.01 | 11.19 | 119 | 51810 | 35932 | 32425665 |
Clostridium difficile colitis | 24.71 | 11.19 | 64 | 51865 | 14267 | 32447330 |
Enterocolitis | 24.62 | 11.19 | 43 | 51886 | 7297 | 32454300 |
Colitis microscopic | 24.30 | 11.19 | 22 | 51907 | 1910 | 32459687 |
Stomatitis | 23.83 | 11.19 | 127 | 51802 | 40102 | 32421495 |
Blood potassium decreased | 23.56 | 11.19 | 71 | 51858 | 17267 | 32444330 |
Enterocolonic fistula | 23.09 | 11.19 | 8 | 51921 | 97 | 32461500 |
Expired product administered | 22.25 | 11.19 | 26 | 51903 | 3049 | 32458548 |
Palmar-plantar erythrodysaesthesia syndrome | 21.88 | 11.19 | 65 | 51864 | 15684 | 32445913 |
Colitis ulcerative | 21.47 | 11.19 | 68 | 51861 | 16983 | 32444614 |
Wrong technique in product usage process | 21.25 | 11.19 | 15 | 51914 | 35044 | 32426553 |
Gastrointestinal obstruction | 21.12 | 11.19 | 14 | 51915 | 766 | 32460831 |
Frequent bowel movements | 20.36 | 11.19 | 46 | 51883 | 9406 | 32452191 |
Mucosal inflammation | 20.10 | 11.19 | 106 | 51823 | 33328 | 32428269 |
Abdominal abscess | 20.06 | 11.19 | 29 | 51900 | 4192 | 32457405 |
Miosis | 19.47 | 11.19 | 43 | 51886 | 8661 | 32452936 |
Proctalgia | 19.39 | 11.19 | 30 | 51899 | 4604 | 32456993 |
Immune-mediated enterocolitis | 18.99 | 11.19 | 18 | 51911 | 1657 | 32459940 |
Dysgeusia | 18.97 | 11.19 | 86 | 51843 | 25445 | 32436152 |
Hepatic haematoma | 18.80 | 11.19 | 11 | 51918 | 482 | 32461115 |
Anal fissure | 18.44 | 11.19 | 23 | 51906 | 2886 | 32458711 |
Atrioventricular block first degree | 18.18 | 11.19 | 33 | 51896 | 5770 | 32455827 |
Intestinal stenosis | 18.12 | 11.19 | 19 | 51910 | 1976 | 32459621 |
Therapeutic product effect decreased | 17.86 | 11.19 | 14 | 51915 | 31003 | 32430594 |
Brain herniation | 17.53 | 11.19 | 26 | 51903 | 3845 | 32457752 |
Pneumonitis | 17.07 | 11.19 | 94 | 51835 | 30040 | 32431557 |
Anal fistula infection | 17.06 | 11.19 | 4 | 51925 | 9 | 32461588 |
Angioedema | 16.69 | 11.19 | 20 | 51909 | 36269 | 32425328 |
Electrocardiogram PR prolongation | 16.65 | 11.19 | 12 | 51917 | 752 | 32460845 |
Right ventricular dilatation | 16.64 | 11.19 | 11 | 51918 | 599 | 32460998 |
Colorectal cancer metastatic | 16.63 | 11.19 | 14 | 51915 | 1103 | 32460494 |
Interstitial lung disease | 16.59 | 11.19 | 51 | 51878 | 64950 | 32396647 |
Lethargy | 16.13 | 11.19 | 117 | 51812 | 41111 | 32420486 |
Autoimmune colitis | 16.04 | 11.19 | 13 | 51916 | 971 | 32460626 |
Gastrointestinal sounds abnormal | 15.99 | 11.19 | 18 | 51911 | 2027 | 32459570 |
Peripheral embolism | 15.96 | 11.19 | 13 | 51916 | 978 | 32460619 |
Gastroenteritis | 15.80 | 11.19 | 54 | 51875 | 14027 | 32447570 |
Coronary artery disease | 15.74 | 11.19 | 35 | 51894 | 49671 | 32411926 |
Intestinal perforation | 15.68 | 11.19 | 40 | 51889 | 8835 | 32452762 |
Product dose omission issue | 15.51 | 11.19 | 98 | 51831 | 102477 | 32359120 |
Gastrointestinal inflammation | 15.31 | 11.19 | 22 | 51907 | 3162 | 32458435 |
Wheezing | 15.24 | 11.19 | 22 | 51907 | 36852 | 32424745 |
Basosquamous carcinoma | 15.00 | 11.19 | 6 | 51923 | 111 | 32461486 |
Flatulence | 14.99 | 11.19 | 66 | 51863 | 19289 | 32442308 |
Intestinal fistula | 14.97 | 11.19 | 12 | 51917 | 882 | 32460715 |
Subileus | 14.87 | 11.19 | 22 | 51907 | 3246 | 32458351 |
Bacterial diarrhoea | 14.79 | 11.19 | 5 | 51924 | 56 | 32461541 |
Musculoskeletal stiffness | 14.73 | 11.19 | 25 | 51904 | 39239 | 32422358 |
Nephroangiosclerosis | 14.73 | 11.19 | 7 | 51922 | 199 | 32461398 |
Malignant neoplasm progression | 14.40 | 11.19 | 190 | 51739 | 78306 | 32383291 |
Off label use | 14.38 | 11.19 | 376 | 51553 | 305944 | 32155653 |
Vascular device infection | 14.28 | 11.19 | 19 | 51910 | 2541 | 32459056 |
Post procedural diarrhoea | 14.26 | 11.19 | 5 | 51924 | 63 | 32461534 |
Drug delivery device placement | 14.13 | 11.19 | 6 | 51923 | 130 | 32461467 |
Sedation | 14.02 | 11.19 | 6 | 51923 | 18520 | 32443077 |
Diffuse alveolar damage | 13.83 | 11.19 | 17 | 51912 | 2102 | 32459495 |
Drug reaction with eosinophilia and systemic symptoms | 13.81 | 11.19 | 19 | 51910 | 32466 | 32429131 |
Proctitis | 13.81 | 11.19 | 18 | 51911 | 2360 | 32459237 |
Neoplasm | 13.75 | 11.19 | 25 | 51904 | 4376 | 32457221 |
Drug resistance | 13.69 | 11.19 | 10 | 51919 | 22955 | 32438642 |
Hypophosphataemia | 13.65 | 11.19 | 38 | 51891 | 8837 | 32452760 |
Cardiac failure | 13.65 | 11.19 | 88 | 51841 | 91585 | 32370012 |
Joint swelling | 13.63 | 11.19 | 40 | 51889 | 51695 | 32409902 |
Immune-mediated hepatitis | 13.45 | 11.19 | 14 | 51915 | 1443 | 32460154 |
Drug level above therapeutic | 13.41 | 11.19 | 21 | 51908 | 3257 | 32458340 |
Dyschromatopsia | 13.36 | 11.19 | 8 | 51921 | 366 | 32461231 |
Pyomyositis | 13.34 | 11.19 | 6 | 51923 | 150 | 32461447 |
Blood magnesium decreased | 13.31 | 11.19 | 29 | 51900 | 5788 | 32455809 |
Eye infection fungal | 13.28 | 11.19 | 8 | 51921 | 370 | 32461227 |
Generalised oedema | 13.25 | 11.19 | 47 | 51882 | 12436 | 32449161 |
Retinal ischaemia | 13.22 | 11.19 | 8 | 51921 | 373 | 32461224 |
Medication error | 13.19 | 11.19 | 10 | 51919 | 22525 | 32439072 |
Gastrointestinal stoma output increased | 13.14 | 11.19 | 4 | 51925 | 31 | 32461566 |
Aggression | 13.08 | 11.19 | 27 | 51902 | 39362 | 32422235 |
Device related infection | 13.02 | 11.19 | 60 | 51869 | 17873 | 32443724 |
Short-bowel syndrome | 13.01 | 11.19 | 7 | 51922 | 260 | 32461337 |
Gastrointestinal stenosis | 12.94 | 11.19 | 5 | 51924 | 84 | 32461513 |
Gastroenteritis staphylococcal | 12.89 | 11.19 | 7 | 51922 | 265 | 32461332 |
Cardiac failure congestive | 12.86 | 11.19 | 81 | 51848 | 84771 | 32376826 |
Necrotising ulcerative gingivostomatitis | 12.68 | 11.19 | 5 | 51924 | 89 | 32461508 |
CSF white blood cell count decreased | 12.61 | 11.19 | 4 | 51925 | 36 | 32461561 |
Blood creatine phosphokinase increased | 12.09 | 11.19 | 35 | 51894 | 45441 | 32416156 |
Splenic vein thrombosis | 12.08 | 11.19 | 8 | 51921 | 437 | 32461160 |
Intracranial mass | 12.04 | 11.19 | 12 | 51917 | 1175 | 32460422 |
Seizure | 12.00 | 11.19 | 107 | 51822 | 103747 | 32357850 |
Biopsy intestine abnormal | 11.94 | 11.19 | 3 | 51926 | 10 | 32461587 |
Feeling abnormal | 11.76 | 11.19 | 53 | 51876 | 60370 | 32401227 |
Mixed dementia | 11.73 | 11.19 | 7 | 51922 | 318 | 32461279 |
Hypokalaemia | 11.67 | 11.19 | 137 | 51792 | 54957 | 32406640 |
No adverse event | 11.61 | 11.19 | 9 | 51920 | 20044 | 32441553 |
Injection site pain | 11.55 | 11.19 | 22 | 51907 | 33036 | 32428561 |
Sleep apnoea syndrome | 11.47 | 11.19 | 8 | 51921 | 18806 | 32442791 |
Drug withdrawal syndrome | 11.39 | 11.19 | 63 | 51866 | 20168 | 32441429 |
Product prescribing error | 11.22 | 11.19 | 9 | 51920 | 19708 | 32441889 |
Faecaloma | 11.21 | 11.19 | 24 | 51905 | 4732 | 32456865 |
Source | Code | Description |
---|---|---|
ATC | A07DA03 | ALIMENTARY TRACT AND METABOLISM ANTIDIARRHEALS, INTESTINAL ANTIINFLAMMATORY/ANTIINFECTIVE AGENTS ANTIPROPULSIVES Antipropulsives |
ATC | A07DA53 | ALIMENTARY TRACT AND METABOLISM ANTIDIARRHEALS, INTESTINAL ANTIINFLAMMATORY/ANTIINFECTIVE AGENTS ANTIPROPULSIVES Antipropulsives |
FDA MoA | N0000000174 | Opioid Agonists |
MeSH PA | D000930 | Antidiarrheals |
MeSH PA | D005765 | Gastrointestinal Agents |
CHEBI has role | CHEBI:55322 | mu opioid agonist |
CHEBI has role | CHEBI:55323 | antiperistaltics |
CHEBI has role | CHEBI:149553 | anti-coronaviral agents |
FDA EPC | N0000175690 | Opioid Agonist |
Disease | Relation | SNOMED_ID | DOID |
---|---|---|---|
Traveler's diarrhea | indication | 11840006 | |
Diarrhea | indication | 62315008 | |
Diarrhea Secondary to Inflammatory Bowel Disease | indication | ||
Chemotherapy-Induced Diarrhea | off-label use | ||
Infectious diarrheal disease | contraindication | 19213003 | DOID:13250 |
Paralytic ileus | contraindication | 55525008 | DOID:8442 |
Hemorrhagic diarrhea | contraindication | 95545007 | |
Disease of liver | contraindication | 235856003 | DOID:409 |
Dissociation level | Dissociation constant | Type (acidic/basic) |
---|---|---|
pKa1 | 7.78 | Basic |
None
Formulation strength | Trade name | Applicant | Application number | Approval date | Type | Dose form | Route | Exclusivity date | Description |
---|---|---|---|---|---|---|---|---|---|
2MG | LOPERAMIDE HYDROCHLORIDE | STRIDES PHARMA | A213070 | Aug. 11, 2021 | OTC | CAPSULE | ORAL | April 20, 2022 | COMPETITIVE GENERIC THERAPY |
Target | Class | Pharos | UniProt | Action | Type | Activity value (-log[M]) | Mechanism action | Bioact source | MoA source |
---|---|---|---|---|---|---|---|---|---|
Mu-type opioid receptor | GPCR | AGONIST | Ki | 8.82 | WOMBAT-PK | CHEMBL | |||
Sodium channel protein type 5 subunit alpha | Ion channel | IC50 | 6.62 | CHEMBL | |||||
Glutamate receptor ionotropic, NMDA 2A | Ion channel | WOMBAT-PK | |||||||
Sigma non-opioid intracellular receptor 1 | Membrane receptor | Ki | 6.58 | DRUG MATRIX | |||||
Sodium-dependent serotonin transporter | Transporter | Ki | 5.93 | DRUG MATRIX | |||||
5-hydroxytryptamine receptor 2B | GPCR | Ki | 5.58 | DRUG MATRIX | |||||
D(3) dopamine receptor | GPCR | Ki | 6.34 | DRUG MATRIX | |||||
Histamine H1 receptor | GPCR | IC50 | 5.70 | WOMBAT-PK | |||||
Histamine H2 receptor | GPCR | Ki | 5.52 | DRUG MATRIX | |||||
Aldehyde oxidase | Enzyme | IC50 | 5 | WOMBAT-PK | |||||
Voltage-dependent P/Q-type calcium channel subunit alpha-1A | Ion channel | WOMBAT-PK | |||||||
Cytochrome P450 2D6 | Enzyme | IC50 | 5.70 | DRUG MATRIX | |||||
Alpha-1D adrenergic receptor | GPCR | Ki | 5.60 | DRUG MATRIX | |||||
Kappa-type opioid receptor | GPCR | Ki | 6.81 | WOMBAT-PK | |||||
Calmodulin | Cytosolic other | WOMBAT-PK | |||||||
Delta-type opioid receptor | GPCR | Ki | 6.91 | WOMBAT-PK | |||||
Somatostatin receptor type 5 | GPCR | Ki | 5.35 | WOMBAT-PK | |||||
Glutamate receptor ionotropic, NMDA 2B | Ion channel | WOMBAT-PK | |||||||
Glutamate receptor ionotropic, NMDA 2C | Ion channel | WOMBAT-PK | |||||||
Glutamate receptor ionotropic, NMDA 2D | Ion channel | WOMBAT-PK | |||||||
Angiopoietin-1 receptor | Kinase | Kd | 5.23 | CHEMBL | |||||
Solute carrier family 22 member 1 | Transporter | IC50 | 4.63 | CHEMBL | |||||
Cocaine esterase | Enzyme | IC50 | 5.39 | CHEMBL | |||||
Sodium channel alpha subunits; brain (Types I, II, III) | Ion channel | IC50 | 6.57 | CHEMBL | |||||
Menin | Unclassified | IC50 | 4.16 | CHEMBL | |||||
Beta-2 adrenergic receptor | GPCR | Ki | 5.69 | DRUG MATRIX | |||||
Alpha-1B adrenergic receptor | GPCR | Ki | 6.27 | DRUG MATRIX | |||||
Membrane-associated progesterone receptor component 1 | Membrane receptor | Ki | 6.07 | DRUG MATRIX | |||||
Alpha-1A adrenergic receptor | GPCR | IC50 | 5.21 | CHEMBL | |||||
Mu-type opioid receptor | GPCR | Ki | 9.80 | CHEMBL | |||||
Delta-type opioid receptor | GPCR | Ki | 7.30 | CHEMBL | |||||
Calmodulin | Cytosolic other | Kd | 5.46 | CHEMBL |
ID | Source |
---|---|
4019804 | VUID |
N0000147893 | NUI |
D00729 | KEGG_DRUG |
34552-83-5 | SECONDARY_CAS_RN |
4019178 | VANDF |
4019804 | VANDF |
C0023992 | UMLSCUI |
CHEBI:6532 | CHEBI |
CHEMBL841 | ChEMBL_ID |
CHEMBL1707 | ChEMBL_ID |
D008139 | MESH_DESCRIPTOR_UI |
DB00836 | DRUGBANK_ID |
7215 | IUPHAR_LIGAND_ID |
3098 | INN_ID |
6X9OC3H4II | UNII |
3955 | PUBCHEM_CID |
151889 | RXNORM |
2069 | MMSL |
2336 | MMSL |
4992 | MMSL |
d01025 | MMSL |
001154 | NDDF |
004545 | NDDF |
116726003 | SNOMEDCT_US |
387040009 | SNOMEDCT_US |
57574005 | SNOMEDCT_US |
Product | Category | Ingredients | NDC | Form | Quantity | Route | Marketing | Label |
---|---|---|---|---|---|---|---|---|
Loperamide Hydrochloride | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0093-0311 | CAPSULE | 2 mg | ORAL | ANDA | 26 sections |
good sense anti diarrheal anti gas | HUMAN OTC DRUG LABEL | 2 | 0113-0087 | TABLET | 2 mg | ORAL | ANDA | 16 sections |
Good Sense anti diarrheal | HUMAN OTC DRUG LABEL | 1 | 0113-0224 | TABLET, FILM COATED | 2 mg | ORAL | ANDA | 16 sections |
Good Sense Anti Diarrheal Anti Gas | HUMAN OTC DRUG LABEL | 2 | 0113-1087 | TABLET | 2 mg | ORAL | ANDA | 16 sections |
Good Sense antidiarrheal | HUMAN OTC DRUG LABEL | 1 | 0113-1645 | SOLUTION | 1 mg | ORAL | ANDA | 16 sections |
anti diarrheal | HUMAN OTC DRUG LABEL | 1 | 0113-2224 | TABLET, FILM COATED | 2 mg | ORAL | ANDA | 16 sections |
basic care loperamide hydrochloride and simethicone | HUMAN OTC DRUG LABEL | 2 | 0113-7119 | TABLET | 2 mg | ORAL | ANDA | 16 sections |
Basic Care loperamide hydrochloride | HUMAN OTC DRUG LABEL | 1 | 0113-7224 | TABLET, FILM COATED | 2 mg | ORAL | ANDA | 16 sections |
Anti-Diarrheal | HUMAN OTC DRUG LABEL | 1 | 0363-0375 | TABLET | 2 mg | ORAL | ANDA | 16 sections |
loperamide hydrochloride | HUMAN OTC DRUG LABEL | 1 | 0363-0645 | SUSPENSION | 1 mg | ORAL | ANDA | 16 sections |
anti diarrheal | HUMAN OTC DRUG LABEL | 1 | 0363-1010 | TABLET, FILM COATED | 2 mg | ORAL | ANDA | 16 sections |
Anti-Diarrheal | HUMAN OTC DRUG LABEL | 1 | 0363-1176 | CAPSULE, LIQUID FILLED | 2 mg | ORAL | NDA | 16 sections |
anti diarrheal and anti gas | HUMAN OTC DRUG LABEL | 2 | 0363-1830 | TABLET | 2 mg | ORAL | ANDA | 16 sections |
Loperamide Hydrochloride | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0378-2100 | CAPSULE | 2 mg | ORAL | ANDA | 29 sections |
Antidiarrheal Relief | HUMAN OTC DRUG LABEL | 1 | 0498-1071 | TABLET | 2 mg | ORAL | ANDA | 16 sections |
Loperamide Hydrochloride | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0615-0362 | CAPSULE | 2 mg | ORAL | ANDA | 25 sections |
Loperamide Hydrochloride | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0615-8087 | CAPSULE | 2 mg | ORAL | ANDA | 29 sections |
loperamide hydrochloride | HUMAN OTC DRUG LABEL | 1 | 0904-6836 | SOLUTION | 1 mg | ORAL | ANDA | 16 sections |
anti diarrheal | HUMAN OTC DRUG LABEL | 1 | 0904-7725 | TABLET, FILM COATED | 2 mg | ORAL | ANDA | 16 sections |
Anti-Diarrheal | HUMAN OTC DRUG LABEL | 1 | 11673-177 | CAPSULE, LIQUID FILLED | 2 mg | ORAL | NDA | 17 sections |
Up and Up anti diarrheal | HUMAN OTC DRUG LABEL | 1 | 11673-224 | TABLET, FILM COATED | 2 mg | ORAL | ANDA | 16 sections |
up and up anti diarrheal anti gas | HUMAN OTC DRUG LABEL | 2 | 11673-646 | TABLET | 2 mg | ORAL | ANDA | 16 sections |
Up and Up anti diarrheal | HUMAN OTC DRUG LABEL | 1 | 11673-900 | SUSPENSION | 1 mg | ORAL | ANDA | 16 sections |
Anti-Diarrheal | HUMAN OTC DRUG LABEL | 1 | 11822-0375 | TABLET | 2 mg | ORAL | ANDA | 16 sections |
anti diarrheal anti gas | HUMAN OTC DRUG LABEL | 2 | 11822-1003 | TABLET | 2 mg | ORAL | ANDA | 16 sections |
loperamide hydrochloride | HUMAN OTC DRUG LABEL | 1 | 11822-1645 | SUSPENSION | 1 mg | ORAL | ANDA | 16 sections |
loperamide hydrochloride | HUMAN OTC DRUG LABEL | 1 | 11822-5519 | SOLUTION | 1 mg | ORAL | ANDA | 16 sections |
Anti-Diarrheal | HUMAN OTC DRUG LABEL | 1 | 11822-7834 | CAPSULE, LIQUID FILLED | 2 mg | ORAL | NDA | 17 sections |
Loperamide Hydrochloride | HUMAN OTC DRUG LABEL | 1 | 15127-338 | TABLET | 2 mg | ORAL | ANDA | 16 sections |
LOPERAMIDE HYDROCHLORIDE | HUMAN PRESCRIPTION DRUG LABEL | 1 | 16590-423 | CAPSULE | 2 mg | ORAL | ANDA | 25 sections |