lanatoside C 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | PK/Tox | Related Drugs | BioActivity |

Stem definitionDrug idCAS RN
1543 17575-22-3

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • lanatoside C
  • allocor
  • cedilanid
  • ceglunat
  • ceglunate
  • celadigal
  • celanid
  • celanide
  • cetosanol
  • Digilanide C
  • Digilanogen C
  • isolanid
  • isolanide
  • Lanatigen C
  • Molecular weight: 985.13
  • Formula: C49H76O20
  • CLOGP: 0.93
  • LIPINSKI: 3
  • HAC: 20
  • HDO: 8
  • TPSA: 288.28
  • ALOGS: -3.52
  • ROTB: 12

Drug dosage:

DoseUnitRoute
1 mg O
1 mg R

ADMET properties:

None

Predicted pharmacokinetic/toxicological properties (PK-AZ):

PropertyDescriptionValueUnitConfidenceSimilarity
azlogd74 LogD at pH 7.4 0.666 High 0.83
caco2-efflux Caco-2 efflux ratio (BA/AB) 29.992 High 0.83
caco2-intrinsic-papp Caco-2 intrinsic apparent permeability 1.923 10^-6 cm/s High 0.83
dh-clint Dog hepatocyte intrinsic clearance 1.517 uL/min/10^6 cells High 0.83
dppb Dog plasma protein binding (% unbound) 70.670 % High 0.83
fcs-ppb Fetal calf serum protein binding (% unbound) 59.720 % High 0.83
herg hERG pIC50 4.262 pIC50 High 0.83
hh-clint Human hepatocyte intrinsic clearance 0.977 uL/min/10^6 cells High 0.83
hlm-clint Human liver microsomal intrinsic clearance 3.396 uL/min/mg protein High 0.83
hppb Human plasma protein binding (% unbound) 70.100 % High 0.83
kinase-safety-class ACVR2B,CAMK2D,CDK5,EIF2AK3,GRK2,ITK,MAP2K6,MAPK10,NTRK2,PDK1,PDK2,PDK4,PRKDC 13
mdck-mdr1-bcrp-efflux MDCK-MDR1-BCRP efflux ratio 1.282 Moderate 0.73
mdck-mdr1-efflux MDCK-MDR1 efflux ratio 10.544 High 0.83
mh-clint Mouse hepatocyte intrinsic clearance 3.350 High 0.83
mppb Mouse plasma protein binding (% unbound) 55.960 High 0.83
nih-mdck-mdr1-efflux NIH MDCK-MDR1 efflux ratio 14.388 High 0.83
pfas-class PFAS structural alert (1 = True, 0 = False) 0
pld-class Phospholipidosis risk class (1 = positive, 0 = negative) 1 Moderate 0.73
pppb Pig plasma protein binding (% unbound) 67.120 % High 0.83
rat-kpuu-brain Rat brain Kpuu 0.009 % Moderate 0.73
rh-clint Rat hepatocyte intrinsic clearance 1.545 uL/min/10^6 cells High 0.83
rh-fuinc Rat hepatocyte fraction unbound in incubation 81.850 % High 0.83
rppb Rat plasma protein binding (% unbound) 57.710 % High 0.83
solubility-dd Solubility at pH 7.4 in DMSO 851.138 uM High 0.83

Approvals:

None

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

None

FDA Adverse Event Reporting System (Geriatric)

None

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
ATC C01AA06 CARDIOVASCULAR SYSTEM
CARDIAC THERAPY
CARDIAC GLYCOSIDES
Digitalis glycosides

Related Drugs by ATC class:

C01AA Digitalis glycosides 7 drugs
acetyldigitoxinacetyldigoxindeslanosidedigitoxindigoxingitoformatemetildigoxin

Drug Use | Suggest Off label Use Form| |View source of the data|

None




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 13.62 acidic
pKa2 13.9 acidic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

None

External reference:

IDSource
D01972 KEGG_DRUG
C0063986 UMLSCUI
CHEMBL506569 ChEMBL_ID
DB13467 DRUGBANK_ID
C018548 MESH_SUPPLEMENTAL_RECORD_UI
393 INN_ID
5RR3JFZ771 UNII
656630 PUBCHEM_CID
27929 RXNORM
000594 NDDF
387338006 SNOMEDCT_US
60541005 SNOMEDCT_US
CHEBI:135898 CHEBI

Pharmaceutical products:

None