digoxin Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
882 20830-75-5

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • digoxin
  • cardiogoxin
  • digoxine
A cardiotonic glycoside obtained mainly from Digitalis lanata; it consists of three sugars and the aglycone DIGOXIGENIN. Digoxin has positive inotropic and negative chronotropic activity. It is used to control ventricular rate in ATRIAL FIBRILLATION and in the management of congestive heart failure with atrial fibrillation. Its use in congestive heart failure and sinus rhythm is less certain. The margin between toxic and therapeutic doses is small. (From Martindale, The Extra Pharmacopoeia, 30th ed, p666)
  • Molecular weight: 780.95
  • Formula: C41H64O14
  • CLOGP: 1.42
  • LIPINSKI: 3
  • HAC: 14
  • HDO: 6
  • TPSA: 203.06
  • ALOGS: -3.79
  • ROTB: 7

  • Status: OFP

  • Legend:
    OFP - off patent
    OFM - off market
    ONP - on patent

Drug dosage:

DoseUnitRoute
0.25 mg O
0.25 mg P

ADMET properties:

PropertyValueReference
BDDCS (Biopharmaceutical Drug Disposition Classification System) 3 Benet LZ, Broccatelli F, Oprea TI
S (Water solubility) 0.99 mg/mL Benet LZ, Broccatelli F, Oprea TI
EoM (Fraction excreted unchanged in urine) 60 % Benet LZ, Broccatelli F, Oprea TI
MRTD (Maximum Recommended Therapeutic Daily Dose) 0.00 ┬ÁM/kg/day Contrera JF, Matthews EJ, Kruhlak NL, Benz RD
BA (Bioavailability) 70 % Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H
Vd (Volume of distribution) 4.10 L/kg Lombardo F, Berellini G, Obach RS
CL (Clearance) 1.70 mL/min/kg Lombardo F, Berellini G, Obach RS
fu (Fraction unbound in plasma) 0.70 % Lombardo F, Berellini G, Obach RS
t_half (Half-life) 38 hours Lombardo F, Berellini G, Obach RS

Approvals:

DateAgencyCompanyOrphan
Oct. 24, 1975 FDA EUROHLTH INTL SARL

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Cardioactive drug level increased 1174.10 10.42 329 78019 1730 46605984
Bradycardia 900.43 10.42 804 77544 65494 46542220
International normalised ratio increased 794.85 10.42 646 77702 46237 46561477
Atrial fibrillation 729.10 10.42 883 77465 102707 46505007
Cardiac failure congestive 559.05 10.42 728 77620 91022 46516692
Toxicity to various agents 470.26 10.42 1072 77276 210694 46397020
Drug interaction 458.58 10.42 1035 77313 202059 46405655
Cardiac failure 384.12 10.42 566 77782 79382 46528332
Drug ineffective 307.45 10.42 415 77933 677423 45930291
Hyperkalaemia 265.32 10.42 374 77974 50335 46557379
Rheumatoid arthritis 239.35 10.42 55 78293 240160 46367554
Acute kidney injury 231.81 10.42 894 77454 234961 46372753
Pulmonary hypertension 194.98 10.42 270 78078 35723 46571991
Bradyarrhythmia 183.22 10.42 82 78266 1924 46605790
Right ventricular failure 177.30 10.42 174 78174 15919 46591795
Product complaint 162.41 10.42 146 78202 11955 46595759
Torsade de pointes 157.93 10.42 144 78204 12010 46595704
Off label use 156.30 10.42 248 78100 379593 46228121
Renal failure 153.49 10.42 479 77869 113115 46494599
Drug hypersensitivity 152.64 10.42 112 78236 243713 46364001
Dyspnoea 146.74 10.42 1412 76936 514136 46093578
Melaena 143.95 10.42 204 78144 27568 46580146
Arthralgia 140.76 10.42 248 78100 364355 46243359
Pain 134.75 10.42 385 77963 476563 46131151
Ventricular tachycardia 134.52 10.42 154 78194 16813 46590901
Pulmonary arterial hypertension 130.77 10.42 188 78160 25740 46581974
Gastrointestinal haemorrhage 127.21 10.42 350 77998 77023 46530691
Cardioactive drug level above therapeutic 114.28 10.42 30 78318 117 46607597
Atrioventricular block 111.34 10.42 92 78256 6719 46600995
Rash 107.11 10.42 279 78069 356233 46251481
Hypotension 105.76 10.42 710 77638 231879 46375835
Arrhythmia 100.89 10.42 197 78151 34644 46573070
Treatment failure 97.31 10.42 19 78329 93068 46514646
Completed suicide 95.21 10.42 64 78284 145856 46461858
Upper gastrointestinal haemorrhage 94.28 10.42 128 78220 16610 46591104
Subdural haematoma 93.10 10.42 112 78236 12885 46594829
Joint swelling 90.65 10.42 87 78261 165986 46441728
Atrioventricular block first degree 87.70 10.42 77 78271 6109 46601605
Injection site pain 86.05 10.42 36 78312 107116 46500598
Nodal rhythm 84.13 10.42 46 78302 1679 46606035
Atrioventricular block complete 83.13 10.42 82 78266 7545 46600169
Syncope 82.79 10.42 372 77976 104431 46503283
Synovitis 79.53 10.42 6 78342 61069 46546645
Drug intolerance 79.12 10.42 78 78270 146971 46460743
Fluid overload 79.05 10.42 154 78194 27031 46580683
Injection site erythema 78.19 10.42 15 78333 74412 46533302
International normalised ratio abnormal 75.88 10.42 53 78295 3006 46604708
Alopecia 75.54 10.42 97 78251 162317 46445397
Drug abuse 75.24 10.42 9 78339 63399 46544315
Lower gastrointestinal haemorrhage 74.81 10.42 76 78272 7244 46600470
Cardioactive drug level decreased 74.63 10.42 20 78328 86 46607628
Therapeutic product effect decreased 74.39 10.42 23 78325 82578 46525136
Oedema peripheral 73.37 10.42 489 77859 159217 46448497
Musculoskeletal stiffness 70.88 10.42 38 78310 97955 46509759
International normalised ratio decreased 67.59 10.42 58 78290 4462 46603252
Nodal arrhythmia 67.56 10.42 36 78312 1247 46606467
Atrial flutter 67.44 10.42 80 78268 9068 46598646
Myocardial infarction 67.38 10.42 333 78015 97195 46510519
Cardiac arrest 67.02 10.42 315 78033 90084 46517630
Drug level increased 65.64 10.42 114 78234 18327 46589387
Psoriasis 65.40 10.42 25 78323 78579 46529135
Cerebral haemorrhage 64.15 10.42 145 78203 28226 46579488
Fluid retention 64.06 10.42 210 78138 50836 46556878
Contraindicated product administered 63.95 10.42 27 78321 79920 46527794
Infusion related reaction 63.86 10.42 46 78302 101162 46506552
Confusional state 63.16 10.42 472 77876 159420 46448294
Pruritus 62.22 10.42 204 78144 242148 46365566
Febrile neutropenia 61.03 10.42 42 78306 94585 46513129
Sinus bradycardia 60.97 10.42 94 78254 13688 46594026
Asthenia 60.63 10.42 792 77556 310283 46297431
Cerebrovascular accident 60.13 10.42 331 78017 100708 46507006
Presyncope 59.83 10.42 129 78219 24325 46583389
Sinusitis 59.81 10.42 78 78270 129690 46478024
Haemorrhage intracranial 59.42 10.42 89 78259 12635 46595079
Injection site reaction 58.77 10.42 6 78342 47843 46559871
Paraesthesia 57.90 10.42 67 78281 117370 46490344
Atrioventricular block second degree 57.32 10.42 49 78299 3750 46603964
Systemic lupus erythematosus 57.18 10.42 19 78329 65161 46542553
Tachyarrhythmia 56.53 10.42 53 78295 4579 46603135
Ventricular fibrillation 55.97 10.42 82 78266 11414 46596300
Therapeutic product effect incomplete 55.51 10.42 31 78317 78122 46529592
Rectal haemorrhage 55.02 10.42 165 78183 38090 46569624
Prothrombin time prolonged 54.98 10.42 74 78274 9522 46598192
Anaemia 54.83 10.42 663 77685 255116 46352598
Orthopnoea 54.61 10.42 58 78290 5822 46601892
Hypoxia 54.41 10.42 201 78147 51637 46556077
Electrocardiogram ST segment depression 53.94 10.42 41 78307 2652 46605062
Ischaemic stroke 53.90 10.42 99 78249 16623 46591091
Dehydration 51.61 10.42 450 77898 159090 46448624
Injection site pruritus 51.47 10.42 4 78344 39739 46567975
Neutropenia 51.03 10.42 102 78246 143102 46464612
Cardiomegaly 50.78 10.42 99 78249 17383 46590331
Nasopharyngitis 50.45 10.42 115 78233 153883 46453831
Sinus node dysfunction 50.29 10.42 48 78300 4241 46603473
Haematoma 50.18 10.42 142 78206 31730 46575984
Blood creatinine increased 49.33 10.42 256 78092 76147 46531567
Suicidal ideation 48.48 10.42 17 78331 56365 46551349
Blood urea increased 48.06 10.42 121 78227 25231 46582483
Hypersensitivity 47.84 10.42 114 78234 150207 46457507
Abdominal wall haematoma 47.26 10.42 39 78309 2842 46604872
Injection site swelling 47.16 10.42 6 78342 40321 46567393
Multiple sclerosis relapse 45.29 10.42 8 78340 42117 46565597
Overdose 44.25 10.42 308 78040 101671 46506043
Ventricular extrasystoles 44.17 10.42 72 78276 10991 46596723
Heart rate decreased 43.90 10.42 135 78213 31588 46576126
Renal injury 43.51 10.42 66 78282 9475 46598239
Ventricular arrhythmia 43.40 10.42 40 78308 3381 46604333
Hyponatraemia 43.35 10.42 305 78043 101027 46506687
Hand deformity 43.34 10.42 4 78344 34570 46573144
Blood potassium increased 43.23 10.42 91 78257 16876 46590838
Arthropathy 43.19 10.42 47 78301 84653 46523061
Dyspnoea exertional 43.10 10.42 183 78165 50106 46557608
Dizziness 43.06 10.42 806 77542 339608 46268106
Activated partial thromboplastin time prolonged 42.36 10.42 55 78293 6834 46600880
Leukopenia 41.89 10.42 32 78316 68311 46539403
Atrial tachycardia 41.85 10.42 32 78316 2088 46605626
Stomatitis 41.83 10.42 32 78316 68265 46539449
Tricuspid valve incompetence 41.45 10.42 79 78269 13638 46594076
Fibromyalgia 41.28 10.42 6 78342 36457 46571257
Urticaria 41.12 10.42 85 78263 117807 46489907
Drug therapeutic incompatibility 40.37 10.42 11 78337 51 46607663
Electrocardiogram QT prolonged 40.35 10.42 182 78166 51143 46556571
Oedema 40.07 10.42 220 78128 66851 46540863
Hypoglycaemia 39.25 10.42 188 78160 54161 46553553
White blood cell count decreased 39.07 10.42 81 78267 112150 46495564
Cardiac failure chronic 38.61 10.42 38 78310 3486 46604228
Electrocardiogram abnormal 38.54 10.42 53 78295 6959 46600755
Decreased appetite 38.29 10.42 495 77853 193341 46414373
Arthritis 38.22 10.42 44 78304 77272 46530442
Neuropathy peripheral 37.55 10.42 59 78289 90834 46516880
Cardiogenic shock 37.33 10.42 84 78264 16300 46591414
Asthma 37.27 10.42 60 78288 91482 46516232
Supraventricular tachycardia 37.15 10.42 74 78274 13196 46594518
Bundle branch block right 36.94 10.42 43 78305 4776 46602938
Coagulopathy 36.86 10.42 90 78258 18409 46589305
Mitral valve incompetence 36.80 10.42 91 78257 18761 46588953
Migraine 36.66 10.42 38 78310 69988 46537726
Electrocardiogram QT shortened 36.31 10.42 12 78336 118 46607596
Intentional product use issue 35.96 10.42 22 78326 52758 46554956
Pleural effusion 35.66 10.42 250 78098 82702 46525012
Glossodynia 35.45 10.42 15 78333 44358 46563356
Product use issue 34.93 10.42 66 78282 94578 46513136
Psoriatic arthropathy 34.84 10.42 9 78339 36370 46571344
Headache 34.57 10.42 580 77768 477772 46129942
Heart rate irregular 34.47 10.42 88 78260 18503 46589211
Depression 34.11 10.42 158 78190 169946 46437768
Embolic stroke 33.98 10.42 36 78312 3603 46604111
Insomnia 33.78 10.42 152 78196 164772 46442942
Xanthopsia 33.58 10.42 12 78336 152 46607562
Cardioactive drug level below therapeutic 33.42 10.42 7 78341 6 46607708
Medication error 33.39 10.42 121 78227 30790 46576924
Atrioventricular dissociation 33.38 10.42 13 78335 212 46607502
Hypocoagulable state 32.86 10.42 21 78327 1026 46606688
Cardiac failure acute 32.83 10.42 53 78295 8025 46599689
Hypoaesthesia 32.61 10.42 97 78251 118772 46488942
Epistaxis 32.61 10.42 202 78146 64103 46543611
Back pain 32.32 10.42 213 78135 209826 46397888
Electrocardiogram ST segment abnormal 31.57 10.42 20 78328 962 46606752
Sleep disorder 31.20 10.42 20 78328 46775 46560939
Pulmonary arterial pressure increased 31.18 10.42 33 78315 3299 46604415
Neutrophil count decreased 31.15 10.42 17 78331 43409 46564305
Chest pain 31.00 10.42 441 77907 175883 46431831
Transfusion 30.33 10.42 68 78280 13163 46594551
Ejection fraction decreased 30.29 10.42 82 78266 17855 46589859
Pulmonary oedema 30.09 10.42 167 78181 50938 46556776
Herpes zoster 30.03 10.42 42 78306 67830 46539884
Intentional self-injury 29.75 10.42 3 78345 24163 46583551
Palpitations 29.38 10.42 266 78082 94993 46512721
Fall 29.32 10.42 741 77607 328356 46279358
Cor pulmonale 29.19 10.42 25 78323 1918 46605796
Bundle branch block left 28.80 10.42 44 78304 6355 46601359
Respiratory failure 28.35 10.42 263 78085 94553 46513161
Renal impairment 27.89 10.42 217 78131 74155 46533559
Left ventricular failure 27.85 10.42 38 78310 4952 46602762
Shock haemorrhagic 27.72 10.42 51 78297 8573 46599141
Death 27.71 10.42 748 77600 334800 46272914
Intentional product misuse 27.70 10.42 23 78325 47105 46560609
Wound 27.58 10.42 19 78329 42783 46564931
Pyrexia 27.46 10.42 416 77932 348386 46259328
Infection 27.42 10.42 123 78225 133469 46474245
Muscle spasms 27.33 10.42 110 78238 123003 46484711
Cardiomyopathy 26.67 10.42 73 78275 16000 46591714
Coagulation time prolonged 26.31 10.42 20 78328 1294 46606420
Oropharyngeal pain 26.25 10.42 53 78295 74115 46533599
Drug monitoring procedure not performed 26.17 10.42 13 78335 388 46607326
Pain in extremity 26.05 10.42 293 78055 258387 46349327
Cardiac disorder 25.61 10.42 143 78205 43715 46563999
Brain natriuretic peptide increased 25.34 10.42 35 78313 4615 46603099
Multiple organ dysfunction syndrome 25.32 10.42 161 78187 51549 46556165
Product dose omission issue 24.86 10.42 173 78175 168347 46439367
Hypochromic anaemia 24.75 10.42 20 78328 1415 46606299
Fatigue 24.59 10.42 807 77541 607890 45999824
Urine output decreased 24.29 10.42 56 78292 11041 46596673
Intentional overdose 24.21 10.42 45 78303 64899 46542815
Malignant neoplasm progression 24.19 10.42 45 78303 64881 46542833
Musculoskeletal pain 24.07 10.42 51 78297 70077 46537637
Rheumatoid factor positive 24.03 10.42 3 78345 20458 46587256
Chromatopsia 23.54 10.42 13 78335 484 46607230
Cardiac pacemaker insertion 23.47 10.42 30 78318 3669 46604045
Erythrodermic psoriasis 23.45 10.42 16 78332 873 46606841
Hyperthyroidism 23.36 10.42 57 78291 11654 46596060
Myocardial ischaemia 23.28 10.42 60 78288 12689 46595025
Drug level above therapeutic 23.13 10.42 29 78319 3480 46604234
Hepatic enzyme increased 22.96 10.42 66 78282 81721 46525993
Tremor 22.82 10.42 108 78240 115531 46492183
Extrasystoles 22.65 10.42 34 78314 4835 46602879
Mitral valve stenosis 22.33 10.42 17 78331 1102 46606612
Pulse absent 22.20 10.42 34 78314 4922 46602792
Loss of consciousness 22.01 10.42 278 78070 107960 46499754
Disorientation 21.97 10.42 121 78227 36797 46570917
Acute respiratory failure 21.91 10.42 102 78246 29036 46578678
Wrong technique in product usage process 21.84 10.42 36 78312 54386 46553328
Catheter management 21.53 10.42 25 78323 2770 46604944
Stupor 21.48 10.42 28 78320 3492 46604222
Toxic epidermal necrolysis 21.40 10.42 84 78264 22194 46585520
Osteoporosis 21.29 10.42 22 78326 40586 46567128
Accidental overdose 21.21 10.42 78 78270 19988 46587726
Product use in unapproved indication 21.09 10.42 79 78269 90194 46517520
Creatinine renal clearance decreased 21.09 10.42 40 78308 6880 46600834
Coronary artery disease 21.02 10.42 112 78236 33640 46574074
Mobility decreased 20.85 10.42 44 78304 60550 46547164
Congestive hepatopathy 20.65 10.42 23 78325 2435 46605279
Oxygen consumption increased 20.60 10.42 28 78320 3635 46604079
Haemoglobin decreased 20.49 10.42 317 78031 128632 46479082
Anxiety 20.37 10.42 201 78147 181756 46425958
Joint stiffness 20.35 10.42 10 78338 27098 46580616
Retroperitoneal haemorrhage 20.33 10.42 24 78324 2706 46605008
Unevaluable event 20.32 10.42 140 78208 46035 46561679
Haematemesis 20.32 10.42 99 78249 28707 46579007
Hypertension 20.31 10.42 221 78127 196135 46411579
Splenic injury 20.31 10.42 9 78339 206 46607508
Swelling 20.29 10.42 124 78224 124387 46483327
Alveolitis 20.23 10.42 23 78325 2490 46605224
Subarachnoid haemorrhage 19.86 10.42 52 78296 11101 46596613
Dilatation ventricular 19.84 10.42 23 78325 2544 46605170
Therapeutic response decreased 19.79 10.42 26 78322 43119 46564595
Aortic valve calcification 19.76 10.42 11 78337 416 46607298
Suicide attempt 19.76 10.42 39 78309 54997 46552717
Occult blood positive 19.64 10.42 27 78321 3543 46604171
Central nervous system injury 19.52 10.42 8 78340 150 46607564
Prothrombin time shortened 19.33 10.42 19 78329 1740 46605974
Neuralgia 19.16 10.42 6 78342 21377 46586337
Metabolic acidosis 19.14 10.42 121 78227 38659 46569055
Potentiating drug interaction 19.12 10.42 28 78320 3895 46603819
Oliguria 18.95 10.42 44 78304 8715 46598999
Drug dependence 18.91 10.42 5 78343 19896 46587818
Pyroglutamic acidosis 18.78 10.42 9 78339 248 46607466
Chills 18.76 10.42 90 78258 95942 46511772
Anaphylactic reaction 18.75 10.42 38 78310 53074 46554640
Haematuria 18.73 10.42 92 78256 26766 46580948
Pulmonary congestion 18.66 10.42 61 78287 14738 46592976
Maternal exposure during pregnancy 18.39 10.42 99 78249 102450 46505264
Lymphocyte count decreased 18.38 10.42 10 78338 25579 46582135
Fear 18.05 10.42 64 78284 16108 46591606
Inappropriate schedule of product administration 17.86 10.42 53 78295 64960 46542754
Blood pressure decreased 17.81 10.42 160 78188 56999 46550715
Dilatation atrial 17.81 10.42 20 78328 2137 46605577
Packed red blood cell transfusion 17.76 10.42 20 78328 2143 46605571
Electrocardiogram PR prolongation 17.72 10.42 12 78336 647 46607067
Hypochromasia 17.69 10.42 9 78339 283 46607431
Hypovolaemia 17.50 10.42 46 78302 9842 46597872
Knee arthroplasty 17.36 10.42 9 78339 23656 46584058
Cardiac murmur 17.16 10.42 50 78298 11354 46596360
Conduction disorder 17.07 10.42 16 78332 1382 46606332
Subcutaneous haematoma 17.05 10.42 17 78331 1584 46606130
Exposure during pregnancy 16.99 10.42 109 78239 108103 46499611
Abdominal discomfort 16.91 10.42 167 78181 150998 46456716
Left atrial dilatation 16.88 10.42 18 78330 1815 46605899
Lethargy 16.86 10.42 145 78203 51026 46556688
Device related infection 16.82 10.42 75 78273 20966 46586748
Haemorrhage 16.79 10.42 153 78195 54716 46552998
Osteoarthritis 16.72 10.42 51 78297 61974 46545740
Brain stem haemorrhage 16.71 10.42 12 78336 711 46607003
Supraventricular extrasystoles 16.65 10.42 27 78321 4102 46603612
Anticoagulation drug level above therapeutic 16.64 10.42 15 78333 1232 46606482
Serotonin syndrome 16.63 10.42 10 78338 24210 46583504
Deep vein thrombosis 16.63 10.42 73 78275 79700 46528014
Fungal infection 16.63 10.42 15 78333 29505 46578209
Transplant evaluation 16.48 10.42 14 78334 1062 46606652
Electrocardiogram repolarisation abnormality 16.45 10.42 15 78333 1250 46606464
Rheumatic heart disease 16.30 10.42 4 78344 11 46607703
Cerebral infarction 16.27 10.42 80 78268 23286 46584428
Pericarditis 16.26 10.42 10 78338 23917 46583797
Cardiopulmonary bypass 16.18 10.42 3 78345 0 46607714
Pneumocystis jirovecii pneumonia 16.16 10.42 3 78345 15245 46592469
Lung transplant 16.11 10.42 22 78326 2870 46604844
Sopor 16.09 10.42 71 78277 19757 46587957
Constipation 16.04 10.42 201 78147 173896 46433818
Electrocardiogram QRS complex prolonged 15.99 10.42 31 78317 5418 46602296
Irritability 15.96 10.42 15 78333 28931 46578783
Rhythm idioventricular 15.81 10.42 7 78341 160 46607554
Neoplasm progression 15.71 10.42 13 78335 26670 46581044
Seizure 15.47 10.42 132 78216 122922 46484792
Left ventricular dysfunction 15.47 10.42 45 78303 10210 46597504
Ventricular hypertrophy 15.47 10.42 25 78323 3789 46603925
Transient ischaemic attack 15.46 10.42 106 78242 34797 46572917
Loss of personal independence in daily activities 15.43 10.42 47 78301 57136 46550578
Depressed mood 15.36 10.42 20 78328 33299 46574415
Hypoglycaemic seizure 15.30 10.42 10 78338 508 46607206
Haemoptysis 15.03 10.42 85 78263 26104 46581610
Ventricular dysfunction 14.96 10.42 21 78327 2811 46604903
Dialysis 14.89 10.42 44 78304 10072 46597642
Cytomegalovirus infection 14.71 10.42 6 78342 18138 46589576
Multiple sclerosis 14.69 10.42 12 78336 24779 46582935
Right ventricular systolic pressure increased 14.69 10.42 10 78338 544 46607170
Obesity 14.63 10.42 3 78345 14203 46593511
Ecchymosis 14.62 10.42 45 78303 10531 46597183
Electrocardiogram R on T phenomenon 14.43 10.42 4 78344 20 46607694
Foot deformity 14.42 10.42 4 78344 15421 46592293
Panic attack 14.41 10.42 8 78340 20234 46587480
No adverse event 14.34 10.42 22 78326 34209 46573505
Choroidal haemorrhage 14.31 10.42 5 78343 59 46607655
Iron deficiency anaemia 14.26 10.42 62 78286 17144 46590570
Oxygen saturation decreased 14.21 10.42 178 78170 68986 46538728
Colitis ulcerative 14.15 10.42 6 78342 17726 46589988
Mitral valve disease 14.13 10.42 18 78330 2194 46605520
Basal ganglia haemorrhage 13.93 10.42 10 78338 592 46607122
Labelled drug-drug interaction medication error 13.90 10.42 40 78308 9021 46598693
Pregnancy 13.89 10.42 15 78333 27122 46580592
Injection site mass 13.87 10.42 4 78344 15036 46592678
Pain in jaw 13.85 10.42 111 78237 38261 46569453
Blood cholesterol increased 13.81 10.42 29 78319 39984 46567730
Bone pain 13.78 10.42 37 78311 46853 46560861
Electrocardiogram change 13.77 10.42 10 78338 603 46607111
Cardioversion 13.71 10.42 13 78335 1139 46606575
Blood culture positive 13.65 10.42 26 78322 4486 46603228
Cyanosis 13.58 10.42 58 78290 15913 46591801
Osteonecrosis of jaw 13.57 10.42 23 78325 34379 46573335
Blood bilirubin increased 13.51 10.42 101 78247 34083 46573631
Abdominal tenderness 13.48 10.42 34 78314 7094 46600620
Exercise tolerance decreased 13.39 10.42 26 78322 4551 46603163
Coronary arterial stent insertion 13.38 10.42 20 78328 2833 46604881
Blood loss anaemia 13.34 10.42 38 78310 8519 46599195
Palmar-plantar erythrodysaesthesia syndrome 13.28 10.42 9 78339 20442 46587272
Ischaemic cardiomyopathy 13.26 10.42 19 78329 2591 46605123
Diabetic ketoacidosis 13.25 10.42 7 78341 18203 46589511
Intervertebral disc protrusion 13.22 10.42 9 78339 20396 46587318
Hip arthroplasty 13.12 10.42 7 78341 18105 46589609
Prerenal failure 13.04 10.42 14 78334 1423 46606291
Atrial thrombosis 12.98 10.42 14 78334 1430 46606284
Right ventricular hypertrophy 12.91 10.42 10 78338 665 46607049
Walking distance test abnormal 12.91 10.42 9 78339 509 46607205
Faeces discoloured 12.79 10.42 59 78289 16728 46590986
Depressed level of consciousness 12.75 10.42 129 78219 47440 46560274
Hypomagnesaemia 12.69 10.42 72 78276 22138 46585576
Calcium deficiency 12.64 10.42 11 78337 862 46606852
Acne 12.62 10.42 9 78339 19910 46587804
Ear infection 12.60 10.42 12 78336 23001 46584713
Delirium 12.53 10.42 106 78242 37122 46570592
Blood pressure increased 12.52 10.42 144 78204 126522 46481192
Anhedonia 12.49 10.42 42 78306 10293 46597421
Red blood cell sedimentation rate increased 12.46 10.42 12 78336 22877 46584837
Pharyngitis 12.44 10.42 7 78341 17576 46590138
Rales 12.41 10.42 40 78308 9591 46598123
Hypersensitivity vasculitis 12.37 10.42 24 78324 4197 46603517
Blood pressure fluctuation 12.34 10.42 20 78328 30428 46577286
Orthostatic hypotension 12.21 10.42 77 78271 24581 46583133
Chronic obstructive pulmonary disease 12.13 10.42 149 78199 57484 46550230
Catheter site erythema 12.11 10.42 23 78325 3960 46603754
Drug withdrawal syndrome 12.06 10.42 17 78331 27367 46580347
Erythema 12.02 10.42 168 78180 142652 46465062
Hypoglycaemic coma 12.01 10.42 18 78330 2556 46605158
Thromboembolectomy 11.95 10.42 4 78344 41 46607673
Catheter site rash 11.94 10.42 10 78338 744 46606970
Anisocytosis 11.91 10.42 9 78339 577 46607137
Paracentesis 11.89 10.42 11 78337 934 46606780
Therapeutic response increased 11.89 10.42 7 78341 295 46607419
Cataract 11.78 10.42 38 78310 45377 46562337
Aortic stenosis 11.74 10.42 24 78324 4358 46603356
Haemodialysis 11.63 10.42 38 78310 9179 46598535
Injection site rash 11.62 10.42 6 78342 15807 46591907
Venous pressure jugular increased 11.61 10.42 8 78340 444 46607270
Peripheral swelling 11.57 10.42 191 78157 157880 46449834
Impaired healing 11.56 10.42 28 78320 36715 46570999
Diabetic metabolic decompensation 11.56 10.42 12 78336 1173 46606541
Cardiorenal syndrome 11.46 10.42 9 78339 611 46607103
Dizziness postural 11.42 10.42 30 78318 6416 46601298
Concomitant disease progression 11.37 10.42 16 78332 2146 46605568
Respiratory distress 11.34 10.42 92 78256 31824 46575890
Dry eye 11.31 10.42 21 78327 30301 46577413
Mucosal inflammation 11.27 10.42 31 78317 38945 46568769
Anger 11.22 10.42 3 78345 11849 46595865
Blood pressure immeasurable 11.21 10.42 12 78336 1215 46606499
Breast cancer 11.18 10.42 39 78309 45479 46562235
Paralysis 11.04 10.42 36 78312 8685 46599029
Foot fracture 10.97 10.42 10 78338 19572 46588142
Catheter site pruritus 10.94 10.42 15 78333 1964 46605750
Polyneuropathy 10.92 10.42 3 78345 11641 46596073
Cardiac valve disease 10.89 10.42 22 78326 3962 46603752
Haematocrit decreased 10.85 10.42 98 78250 34959 46572755
Adams-Stokes syndrome 10.83 10.42 4 78344 56 46607658
Microcytic anaemia 10.82 10.42 19 78329 3079 46604635
C-reactive protein increased 10.81 10.42 56 78292 58534 46549180
Aortic valve incompetence 10.80 10.42 28 78320 5942 46601772
Acute myocardial infarction 10.79 10.42 91 78257 31833 46575881
Ventricular failure 10.72 10.42 7 78341 355 46607359
Azotaemia 10.69 10.42 23 78325 4328 46603386
Lactic acidosis 10.60 10.42 95 78253 33814 46573900
Hyperchloraemia 10.58 10.42 9 78339 684 46607030
Heart sounds abnormal 10.57 10.42 9 78339 685 46607029
Nephrolithiasis 10.55 10.42 25 78323 33026 46574688
Prothrombin level increased 10.54 10.42 6 78342 237 46607477
Cough 10.52 10.42 300 78048 229949 46377765
Cerebellar haematoma 10.51 10.42 7 78341 367 46607347
Hepatic steatosis 10.51 10.42 15 78333 24027 46583687
Upper respiratory tract infection 10.50 10.42 63 78285 63493 46544221
Blood alkaline phosphatase increased 10.42 10.42 107 78241 39502 46568212

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Cardioactive drug level increased 770.38 10.84 241 67167 1398 29883672
Bradycardia 649.68 10.84 768 66640 64758 29820312
Cardiac failure congestive 576.59 10.84 823 66585 83584 29801486
Atrial fibrillation 535.63 10.84 909 66499 107215 29777855
International normalised ratio increased 524.07 10.84 590 66818 47149 29837921
Ventricular tachycardia 243.11 10.84 284 67124 23578 29861492
Cardiac failure 226.67 10.84 547 66861 82871 29802199
Hyperkalaemia 180.45 10.84 434 66974 65576 29819494
Product complaint 157.03 10.84 119 67289 5687 29879383
Toxicity to various agents 156.98 10.84 800 66608 176383 29708687
Drug abuse 155.03 10.84 7 67401 82065 29803005
Off label use 146.58 10.84 209 67199 249081 29635989
Gastrointestinal haemorrhage 122.90 10.84 440 66968 83006 29802064
Drug ineffective 121.46 10.84 379 67029 340008 29545062
Drug interaction 116.00 10.84 807 66601 198761 29686309
Venous pressure jugular increased 113.48 10.84 47 67361 664 29884406
Cardiac murmur 89.78 10.84 93 67315 6741 29878329
Hypotension 88.59 10.84 761 66647 199804 29685266
Acute kidney injury 87.21 10.84 970 66438 272872 29612198
Right ventricular failure 84.06 10.84 97 67311 7939 29877131
Dyspnoea 82.99 10.84 1127 66281 332168 29552902
Cardioactive drug level above therapeutic 82.51 10.84 21 67387 47 29885023
Atrial flutter 78.35 10.84 126 67282 14155 29870915
Melaena 77.74 10.84 203 67205 32234 29852836
Myocardial infarction 73.98 10.84 510 66898 125115 29759955
Ischaemic cardiomyopathy 70.94 10.84 79 67329 6218 29878852
Febrile neutropenia 69.13 10.84 83 67325 106610 29778460
Nodal rhythm 66.75 10.84 41 67367 1382 29883688
Neutropenia 66.59 10.84 117 67291 128423 29756647
Ventricular fibrillation 66.48 10.84 121 67287 15017 29870053
Bradyarrhythmia 66.44 10.84 46 67362 1906 29883164
Cardiac arrest 65.09 10.84 394 67014 92456 29792614
Arrhythmia 65.09 10.84 193 67215 32976 29852094
Dizziness 64.92 10.84 697 66711 194212 29690858
Cardioactive drug level decreased 61.81 10.84 17 67391 57 29885013
Pulmonary hypertension 59.44 10.84 132 67276 18904 29866166
Ventricular extrasystoles 58.57 10.84 98 67310 11376 29873694
Product dose omission issue 55.49 10.84 75 67333 91556 29793514
Product use in unapproved indication 52.48 10.84 53 67355 73640 29811430
Tricuspid valve incompetence 51.34 10.84 79 67329 8544 29876526
Cardiomegaly 50.34 10.84 105 67303 14404 29870666
Prothrombin time prolonged 49.55 10.84 81 67327 9222 29875848
Atrioventricular block 49.51 10.84 71 67337 7211 29877859
Rheumatoid arthritis 48.65 10.84 16 67392 41181 29843889
Xanthopsia 47.98 10.84 17 67391 152 29884918
Pyrexia 47.57 10.84 429 66979 294060 29591010
International normalised ratio decreased 47.32 10.84 55 67353 4535 29880535
Atrioventricular block complete 46.77 10.84 75 67333 8402 29876668
Mitral valve incompetence 45.01 10.84 95 67313 13139 29871931
Rash 44.89 10.84 251 67157 191638 29693432
Left ventricular dysfunction 44.05 10.84 74 67334 8617 29876453
Heart rate irregular 44.03 10.84 90 67318 12169 29872901
Cardiogenic shock 44.00 10.84 109 67299 16752 29868318
Subdural haematoma 43.68 10.84 117 67291 18855 29866215
Drug hypersensitivity 43.62 10.84 54 67354 68465 29816605
Arthralgia 43.53 10.84 158 67250 135633 29749437
Torsade de pointes 42.98 10.84 66 67342 7124 29877946
Coronary artery disease 42.79 10.84 223 67185 49489 29835581
Renal failure 42.76 10.84 461 66947 128505 29756565
Completed suicide 41.82 10.84 102 67306 99390 29785680
Cardiomyopathy 41.76 10.84 100 67308 15043 29870027
Cardiac failure chronic 41.09 10.84 58 67350 5805 29879265
Confusional state 41.07 10.84 474 66934 134360 29750710
Cerebrovascular accident 40.59 10.84 324 67084 83153 29801917
Headache 39.17 10.84 245 67163 182061 29703009
Intentional product use issue 38.29 10.84 17 67391 36423 29848647
Pruritus 38.23 10.84 137 67271 118067 29767003
Heart rate decreased 38.21 10.84 119 67289 20875 29864195
Atrioventricular block first degree 37.99 10.84 55 67353 5633 29879437
Sinus node dysfunction 37.88 10.84 45 67363 3798 29881272
Left ventricular failure 37.41 10.84 51 67357 4940 29880130
Asthenia 37.33 10.84 702 66706 220588 29664482
Syncope 36.73 10.84 321 67087 84582 29800488
Pulmonary arterial hypertension 36.67 10.84 71 67337 9230 29875840
Haematuria 36.45 10.84 198 67210 44636 29840434
Nodal arrhythmia 35.94 10.84 23 67385 834 29884236
Ventricular arrhythmia 35.50 10.84 46 67362 4242 29880828
Supraventricular tachycardia 34.08 10.84 73 67335 10199 29874871
Blood urea increased 33.66 10.84 150 67258 31231 29853839
Intentional product misuse 33.65 10.84 18 67390 34649 29850421
Psoriasis 33.29 10.84 28 67380 42478 29842592
Atrial tachycardia 33.18 10.84 32 67376 2127 29882943
Leukopenia 32.94 10.84 47 67361 56112 29828958
White blood cell count decreased 32.26 10.84 90 67318 83857 29801213
Injection site pain 32.06 10.84 14 67394 30296 29854774
Nasopharyngitis 31.87 10.84 52 67356 58797 29826273
Blood lactic acid 31.72 10.84 16 67392 364 29884706
Chronic obstructive pulmonary disease 31.18 10.84 194 67214 45932 29839138
Neuropathy peripheral 30.60 10.84 71 67337 70404 29814666
Coagulopathy 30.21 10.84 101 67307 18386 29866684
Dissociation 30.07 10.84 23 67385 1114 29883956
Cardiac disorder 29.65 10.84 172 67236 39721 29845349
Ejection fraction decreased 29.47 10.84 88 67320 15087 29869983
Ischaemic stroke 29.38 10.84 92 67316 16183 29868887
Intentional overdose 29.33 10.84 30 67378 41451 29843619
Oedema peripheral 29.11 10.84 365 67043 105467 29779603
Jugular vein distension 29.07 10.84 17 67391 523 29884547
Electrocardiogram ST segment depression 28.98 10.84 31 67377 2331 29882739
Orthostatic hypotension 28.31 10.84 118 67290 23861 29861209
Aortic stenosis 28.30 10.84 40 67368 4008 29881062
Cytomegalovirus infection 28.29 10.84 9 67399 23665 29861405
Cardiorenal syndrome 28.28 10.84 19 67389 749 29884321
Conduction disorder 28.27 10.84 28 67380 1923 29883147
Blood creatinine increased 28.13 10.84 322 67086 91053 29794017
Suicidal ideation 28.02 10.84 24 67384 36090 29848980
Depression 27.80 10.84 107 67301 90330 29794740
Neutrophil count decreased 27.49 10.84 33 67375 42421 29842649
Drug dependence 27.47 10.84 7 67401 21288 29863782
Stomatitis 27.46 10.84 26 67382 37253 29847817
Haematoma 26.83 10.84 116 67292 23837 29861233
Congestive cardiomyopathy 26.63 10.84 51 67357 6576 29878494
Mucosal inflammation 26.56 10.84 18 67390 30476 29854594
Blood potassium increased 25.98 10.84 88 67320 16125 29868945
Bundle branch block left 25.96 10.84 44 67364 5160 29879910
Cardioactive drug level below therapeutic 25.49 10.84 5 67403 0 29885070
International normalised ratio abnormal 24.88 10.84 33 67375 3113 29881957
Pleural effusion 24.62 10.84 265 67143 73801 29811269
Product use issue 24.60 10.84 41 67367 45975 29839095
Oedema 24.33 10.84 173 67235 42820 29842250
Fall 24.08 10.84 557 66851 181315 29703755
Dyspnoea exertional 23.93 10.84 149 67259 35281 29849789
Myasthenic syndrome 23.93 10.84 13 67395 346 29884724
Peripheral embolism 23.80 10.84 18 67390 857 29884213
Therapeutic product effect incomplete 23.32 10.84 25 67383 33809 29851261
Diabetic ketoacidosis 23.20 10.84 4 67404 15982 29869088
Anuria 23.12 10.84 63 67345 10253 29874817
Dilatation atrial 22.87 10.84 26 67382 2093 29882977
Faeces discoloured 22.61 10.84 76 67332 13870 29871200
Malignant neoplasm progression 22.55 10.84 85 67323 72202 29812868
Epistaxis 22.21 10.84 199 67209 52782 29832288
Hypersensitivity 22.21 10.84 56 67352 53972 29831098
Polymerase chain reaction 22.15 10.84 8 67400 76 29884994
Drug reaction with eosinophilia and systemic symptoms 22.02 10.84 19 67389 28469 29856601
Upper gastrointestinal haemorrhage 21.92 10.84 103 67305 21925 29863145
Cardiac output decreased 21.67 10.84 17 67391 855 29884215
Brain natriuretic peptide increased 21.31 10.84 35 67373 4000 29881070
Benign gastrointestinal neoplasm 21.24 10.84 9 67399 135 29884935
Lethargy 21.20 10.84 157 67251 39362 29845708
Cardiac death 21.17 10.84 18 67390 1015 29884055
Dilatation ventricular 21.02 10.84 28 67380 2652 29882418
Orthopnoea 20.84 10.84 37 67371 4503 29880567
Concomitant disease progression 20.81 10.84 27 67381 2493 29882577
Psoriatic arthropathy 20.68 10.84 5 67403 15756 29869314
Intentional self-injury 20.51 10.84 3 67405 13529 29871541
Renal impairment 20.49 10.84 284 67124 83900 29801170
Back pain 20.41 10.84 141 67267 102455 29782615
Lip discolouration 20.38 10.84 9 67399 150 29884920
Oesophageal achalasia 20.37 10.84 11 67397 289 29884781
Blood pressure increased 20.28 10.84 88 67320 71840 29813230
Drug resistance 20.21 10.84 10 67398 20123 29864947
Pain 20.00 10.84 271 67137 172370 29712700
Activated partial thromboplastin time prolonged 19.78 10.84 50 67358 7778 29877292
Drug withdrawal syndrome 19.64 10.84 10 67398 19799 29865271
Pancytopenia 19.43 10.84 112 67296 84940 29800130
Fluid retention 19.37 10.84 109 67299 24889 29860181
Haemorrhage intracranial 19.36 10.84 76 67332 14956 29870114
Lymphadenopathy 19.16 10.84 16 67392 24360 29860710
Infusion related reaction 19.14 10.84 39 67369 40525 29844545
Muscle spasms 19.10 10.84 78 67330 64760 29820310
Palpitations 18.94 10.84 135 67273 33438 29851632
Creatinine renal clearance decreased 18.69 10.84 30 67378 3363 29881707
Treatment failure 18.44 10.84 31 67377 34648 29850422
Ventricular dysfunction 18.28 10.84 31 67377 3636 29881434
Irritability 18.27 10.84 15 67393 23035 29862035
Electrocardiogram repolarisation abnormality 18.23 10.84 14 67394 682 29884388
Colitis ulcerative 18.13 10.84 5 67403 14429 29870641
Acute myocardial infarction 17.86 10.84 190 67218 52749 29832321
Enzyme induction 17.74 10.84 6 67402 46 29885024
Hepatitis C 17.70 10.84 4 67404 13201 29871869
Hyperthyroidism 17.70 10.84 49 67359 8049 29877021
Ventricular hypertrophy 17.69 10.84 36 67372 4851 29880219
Burning feet syndrome 17.64 10.84 7 67401 88 29884982
Atrioventricular block second degree 17.62 10.84 28 67380 3112 29881958
Coronary artery bypass 17.48 10.84 37 67371 5125 29879945
Haemorrhage 17.27 10.84 169 67239 45910 29839160
Insomnia 17.25 10.84 131 67277 93205 29791865
Chromatopsia 17.11 10.84 9 67399 224 29884846
Transient ischaemic attack 17.03 10.84 106 67302 25094 29859976
Tachycardia foetal 16.72 10.84 10 67398 321 29884749
Diverticulum intestinal haemorrhagic 16.60 10.84 22 67386 2073 29882997
Cardiac failure acute 16.57 10.84 52 67356 9157 29875913
Drug intolerance 16.34 10.84 50 67358 45241 29839829
Pulmonary arterial pressure increased 16.29 10.84 16 67392 1088 29883982
Hepatocellular injury 16.27 10.84 20 67388 25451 29859619
Brain natriuretic peptide 16.12 10.84 5 67403 28 29885042
Joint swelling 16.11 10.84 53 67355 46893 29838177
Embolic stroke 15.96 10.84 29 67379 3593 29881477
Anaphylactic reaction 15.83 10.84 24 67384 27958 29857112
Sinusitis 15.78 10.84 32 67376 33313 29851757
Injury 15.69 10.84 93 67315 21638 29863432
Eosinophilia 15.69 10.84 16 67392 22144 29862926
Hyponatraemia 15.66 10.84 225 67183 66977 29818093
Influenza 15.59 10.84 48 67360 43350 29841720
Peripheral coldness 15.56 10.84 41 67367 6542 29878528
Drug-induced liver injury 15.48 10.84 15 67393 21259 29863811
Aortic valve stenosis 15.29 10.84 19 67389 1680 29883390
Subdural haemorrhage 15.28 10.84 25 67383 2847 29882223
Normochromic normocytic anaemia 15.28 10.84 30 67378 3940 29881130
Mitral valve sclerosis 15.22 10.84 7 67401 129 29884941
Presyncope 15.19 10.84 74 67334 15982 29869088
Congestive hepatopathy 15.10 10.84 20 67388 1884 29883186
Pneumocystis jirovecii pneumonia 15.05 10.84 10 67398 17110 29867960
COVID-19 14.98 10.84 11 67397 17867 29867203
Abnormal loss of weight 14.96 10.84 29 67379 3773 29881297
Polypectomy 14.89 10.84 11 67397 505 29884565
Cerebral haematoma 14.88 10.84 32 67376 4482 29880588
Sleep disorder 14.83 10.84 20 67388 24459 29860611
Anhedonia 14.82 10.84 47 67361 8322 29876748
Urticaria 14.67 10.84 68 67340 54538 29830532
Arthropathy 14.64 10.84 15 67393 20712 29864358
Tricuspid valve sclerosis 14.60 10.84 5 67403 40 29885030
Haematemesis 14.56 10.84 105 67303 26098 29858972
Right atrial dilatation 14.53 10.84 9 67399 308 29884762
Gastric mucosal lesion 14.34 10.84 11 67397 535 29884535
Cyanosis 14.30 10.84 59 67349 11876 29873194
Cerebral infarction 14.27 10.84 105 67303 26268 29858802
Constipation 14.26 10.84 174 67234 112732 29772338
Somnolence 14.25 10.84 144 67264 96619 29788451
Palmar-plantar erythrodysaesthesia syndrome 14.02 10.84 8 67400 14862 29870208
Tracheal injury 13.99 10.84 4 67404 16 29885054
Withdrawal syndrome 13.94 10.84 4 67404 11246 29873824
Aspergillus infection 13.88 10.84 3 67405 10211 29874859
Haemothorax 13.88 10.84 27 67381 3522 29881548
Dyspnoea paroxysmal nocturnal 13.79 10.84 15 67393 1150 29883920
Atrial thrombosis 13.76 10.84 19 67389 1862 29883208
Graft versus host disease 13.76 10.84 3 67405 10147 29874923
Electrocardiogram QRS complex prolonged 13.73 10.84 30 67378 4247 29880823
N-terminal prohormone brain natriuretic peptide increased 13.66 10.84 16 67392 1330 29883740
Suicide attempt 13.60 10.84 40 67368 36657 29848413
Inappropriate schedule of product administration 13.53 10.84 45 67363 39683 29845387
Colitis 13.41 10.84 31 67377 30789 29854281
Electrocardiogram abnormal 13.22 10.84 36 67372 5856 29879214
Chills 13.14 10.84 102 67306 72236 29812834
Electrocardiogram ST-T change 13.11 10.84 11 67397 609 29884461
Synovitis 13.04 10.84 3 67405 9780 29875290
Rectal haemorrhage 13.02 10.84 128 67280 34811 29850259
Dystonia 12.93 10.84 3 67405 9724 29875346
Tremor 12.89 10.84 108 67300 75255 29809815
Generalised tonic-clonic seizure 12.86 10.84 15 67393 19536 29865534
Infection 12.85 10.84 113 67295 77961 29807109
Haematocrit decreased 12.70 10.84 115 67293 30584 29854486
Angina unstable 12.57 10.84 58 67350 12252 29872818
Osteonecrosis of jaw 12.56 10.84 14 67394 18604 29866466
Oliguria 12.47 10.84 41 67367 7398 29877672
Neuralgia 12.47 10.84 4 67404 10462 29874608
Rash maculo-papular 12.37 10.84 24 67384 25394 29859676
Hypovolaemia 12.31 10.84 45 67363 8560 29876510
Limited symptom panic attack 12.18 10.84 5 67403 69 29885001
Tumour lysis syndrome 12.05 10.84 7 67401 12878 29872192
Cerebral haemorrhage 12.02 10.84 120 67288 32767 29852303
Morning glory syndrome 12.01 10.84 3 67405 6 29885064
Musculoskeletal pain 12.00 10.84 33 67375 30907 29854163
Blood pressure fluctuation 11.98 10.84 13 67395 17490 29867580
Transplant rejection 11.92 10.84 3 67405 9203 29875867
Mania 11.82 10.84 3 67405 9151 29875919
Cardioversion 11.76 10.84 12 67396 854 29884216
Drug level increased 11.65 10.84 76 67332 18278 29866792
Urine leukocyte esterase positive 11.63 10.84 8 67400 328 29884742
Herpes zoster 11.57 10.84 32 67376 29911 29855159
Bundle branch block 11.50 10.84 12 67396 877 29884193
Electrocardiogram ST segment abnormal 11.49 10.84 10 67398 582 29884488
Wrong patient received product 11.31 10.84 17 67391 1800 29883270
Encephalopathy 11.30 10.84 36 67372 32169 29852901
Seizure 11.23 10.84 155 67253 98320 29786750
Pulmonary embolism 11.20 10.84 117 67291 78018 29807052
Lymphopenia 11.15 10.84 8 67400 13155 29871915
Erythema 11.09 10.84 116 67292 77335 29807735
Emotional distress 11.08 10.84 67 67341 15698 29869372
Medication error 11.06 10.84 83 67325 20889 29864181
Pain in extremity 11.02 10.84 178 67230 110043 29775027
Posterior reversible encephalopathy syndrome 10.97 10.84 3 67405 8704 29876366
Aortic valve incompetence 10.97 10.84 30 67378 4893 29880177
Tinnitus 10.96 10.84 12 67396 16076 29868994
Haemodynamic test abnormal 10.89 10.84 4 67404 40 29885030

Pharmacologic Action:

SourceCodeDescription
ATC C01AA05 CARDIOVASCULAR SYSTEM
CARDIAC THERAPY
CARDIAC GLYCOSIDES
Digitalis glycosides
FDA CS M0003451 Cardiac Glycosides
FDA EPC N0000175568 Cardiac Glycoside
CHEBI has role CHEBI:38070 antiarrhythmic agent
CHEBI has role CHEBI:38147 cardiotonic drugs
CHEBI has role CHEBI:53000 epitope function
CHEBI has role CHEBI:63510 na(+)/k(+)-pump inhibitors
MeSH PA D000889 Anti-Arrhythmia Agents
MeSH PA D002316 Cardiotonic Agents
MeSH PA D002317 Cardiovascular Agents
MeSH PA D004791 Enzyme Inhibitors
MeSH PA D020011 Protective Agents

Drug Use (View source of the data)

DiseaseRelationSNOMED_IDDOID
Poisoning by digitalis glycoside indication 12876009
Chronic heart failure indication 48447003
Atrial fibrillation indication 49436004 DOID:0060224
Senile cardiac amyloidosis contraindication 16573007
Myocardial infarction contraindication 22298006 DOID:5844
Sick sinus syndrome contraindication 36083008 DOID:13884
Myxedema contraindication 43153006 DOID:11634
Hypokalemia contraindication 43339004
Sinus bradycardia contraindication 49710005
Myocarditis contraindication 50920009 DOID:820
Acute nephropathy contraindication 58574008
Hypercalcemia contraindication 66931009 DOID:12678
Ventricular fibrillation contraindication 71908006
Wolff-Parkinson-White pattern contraindication 74390002 DOID:384
Cor pulmonale contraindication 83291003 DOID:8515
Constrictive pericarditis contraindication 85598007 DOID:11481
Kidney disease contraindication 90708001 DOID:557
Hypomagnesemia contraindication 190855004
Atrioventricular block contraindication 233917008 DOID:0050820
Idiopathic hypertrophic subaortic stenosis contraindication 360465008
Restrictive cardiomyopathy contraindication 415295002 DOID:397

Acid dissociation constants calculated using MoKa v3.0.0

None

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
Sodium/potassium-transporting ATPase Transporter INHIBITOR IC50 6.40 CHEMBL CHEMBL
Potassium voltage-gated channel subfamily H member 2 Ion channel IC50 4.14 WOMBAT-PK
Signal transducer and activator of transcription 3 Transcription factor IC50 5.73 CHEMBL
Nuclear receptor ROR-gamma Nuclear hormone receptor IC50 5.70 CHEMBL
Sodium/potassium-transporting ATPase subunit alpha-1 Transporter IC50 6.30 CHEMBL
Sodium/potassium-transporting ATPase subunit alpha-2 Ion channel IC50 5.78 DRUG MATRIX
Nuclear receptor ROR-gamma Unclassified IC50 5.70 CHEMBL

External reference:

IDSource
4018047 VUID
N0000146388 NUI
D00298 KEGG_DRUG
4018047 VANDF
C2825111 UMLSCUI
CHEBI:4551 CHEBI
DGX PDB_CHEM_ID
CHEMBL1751 ChEMBL_ID
DB00390 DRUGBANK_ID
D004077 MESH_DESCRIPTOR_UI
3062 PUBCHEM_CID
4726 IUPHAR_LIGAND_ID
389 INN_ID
73K4184T59 UNII
3407 RXNORM
1413 MMSL
4597 MMSL
d00210 MMSL
000593 NDDF
387461009 SNOMEDCT_US
796001 SNOMEDCT_US

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
Digoxin HUMAN PRESCRIPTION DRUG LABEL 1 0054-0057 SOLUTION 0.05 mg ORAL NDA 27 sections
Digoxin HUMAN PRESCRIPTION DRUG LABEL 1 0115-9811 TABLET 125 ug ORAL ANDA 26 sections
Digoxin HUMAN PRESCRIPTION DRUG LABEL 1 0115-9822 TABLET 250 ug ORAL ANDA 26 sections
Digoxin HUMAN PRESCRIPTION DRUG LABEL 1 0143-1240 TABLET 125 ug ORAL ANDA 26 sections
Digoxin HUMAN PRESCRIPTION DRUG LABEL 1 0143-1241 TABLET 250 ug ORAL ANDA 26 sections
DIGITEK HUMAN PRESCRIPTION DRUG LABEL 1 0378-6155 TABLET 0.13 mg ORAL ANDA 26 sections
DIGITEK HUMAN PRESCRIPTION DRUG LABEL 1 0378-6156 TABLET 0.25 mg ORAL ANDA 26 sections
DIGOX HUMAN PRESCRIPTION DRUG LABEL 1 0527-1324 TABLET 125 ug ORAL ANDA 22 sections
DIGOX HUMAN PRESCRIPTION DRUG LABEL 1 0527-1325 TABLET 250 ug ORAL ANDA 22 sections
Digoxin HUMAN PRESCRIPTION DRUG LABEL 1 0615-0547 TABLET 0.13 mg ORAL ANDA 12 sections
Digoxin HUMAN PRESCRIPTION DRUG LABEL 1 0615-7729 TABLET 125 ug ORAL ANDA 22 sections
Digoxin HUMAN PRESCRIPTION DRUG LABEL 1 0615-7730 TABLET 250 ug ORAL ANDA 22 sections
Digoxin HUMAN PRESCRIPTION DRUG LABEL 1 0615-8202 TABLET 125 ug ORAL ANDA 27 sections
Digoxin HUMAN PRESCRIPTION DRUG LABEL 1 0641-1410 INJECTION 0.25 mg INTRAMUSCULAR ANDA 26 sections
Digoxin HUMAN PRESCRIPTION DRUG LABEL 1 0641-6184 INJECTION 0.25 mg INTRAMUSCULAR ANDA 26 sections
Digoxin HUMAN PRESCRIPTION DRUG LABEL 1 0781-3059 INJECTION, SOLUTION 250 ug INTRAMUSCULAR ANDA 26 sections
Digoxin HUMAN PRESCRIPTION DRUG LABEL 1 0904-5921 TABLET 125 ug ORAL ANDA 26 sections
Digoxin HUMAN PRESCRIPTION DRUG LABEL 1 0904-5922 TABLET 250 ug ORAL ANDA 26 sections
Digoxin HUMAN PRESCRIPTION DRUG LABEL 1 16714-590 TABLET 125 ug ORAL ANDA 25 sections
Digoxin HUMAN PRESCRIPTION DRUG LABEL 1 16714-591 TABLET 250 ug ORAL ANDA 25 sections
Digoxin HUMAN PRESCRIPTION DRUG LABEL 1 17856-0057 SOLUTION 0.05 mg ORAL NDA 25 sections
Digoxin HUMAN PRESCRIPTION DRUG LABEL 1 21695-678 TABLET 0.13 mg ORAL ANDA 17 sections
LANOXIN HUMAN PRESCRIPTION DRUG LABEL 1 24987-262 INJECTION, SOLUTION 100 ug INTRAMUSCULAR NDA 24 sections
DIGITEK HUMAN PRESCRIPTION DRUG LABEL 1 42292-002 TABLET 0.25 mg ORAL ANDA 26 sections
DIGITEK HUMAN PRESCRIPTION DRUG LABEL 1 42292-003 TABLET 0.13 mg ORAL ANDA 26 sections
Digoxin HUMAN PRESCRIPTION DRUG LABEL 1 50090-4432 TABLET 125 ug ORAL ANDA 28 sections
Digoxin HUMAN PRESCRIPTION DRUG LABEL 1 50090-5276 TABLET 125 ug ORAL ANDA 22 sections
Digoxin HUMAN PRESCRIPTION DRUG LABEL 1 50090-5311 TABLET 250 ug ORAL ANDA 22 sections
Digoxin HUMAN PRESCRIPTION DRUG LABEL 1 50436-0324 TABLET 125 ug ORAL ANDA 22 sections
Digoxin HUMAN PRESCRIPTION DRUG LABEL 1 50564-544 TABLET 125 ug ORAL ANDA 22 sections