digoxin 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | PK/Tox | Related Drugs | BioActivity |

Stem definitionDrug idCAS RN
882 20830-75-5

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • digoxin
  • cardiogoxin
  • digoxine
A cardiotonic glycoside obtained mainly from Digitalis lanata; it consists of three sugars and the aglycone DIGOXIGENIN. Digoxin has positive inotropic and negative chronotropic activity. It is used to control ventricular rate in ATRIAL FIBRILLATION and in the management of congestive heart failure with atrial fibrillation. Its use in congestive heart failure and sinus rhythm is less certain. The margin between toxic and therapeutic doses is small. (From Martindale, The Extra Pharmacopoeia, 30th ed, p666)
  • Molecular weight: 780.95
  • Formula: C41H64O14
  • CLOGP: 1.42
  • LIPINSKI: 3
  • HAC: 14
  • HDO: 6
  • TPSA: 203.06
  • ALOGS: -3.79
  • ROTB: 7
  • Status: OFP
    • Legend:
    OFP - off patent
    OFM - off market
    ONP - on patent

Drug dosage:

DoseUnitRoute
0.25 mg O
0.25 mg P

ADMET properties:

PropertyValueReference
BDDCS (Biopharmaceutical Drug Disposition Classification System) 3 Benet LZ, Broccatelli F, Oprea TI
S (Water solubility) 0.06 mg/mL Bocci G, Oprea TI, Benet LZ
EoM (Fraction excreted unchanged in urine) 60 % Benet LZ, Broccatelli F, Oprea TI
MRTD (Maximum Recommended Therapeutic Daily Dose) 0.00 µM/kg/day Contrera JF, Matthews EJ, Kruhlak NL, Benz RD
BA (Bioavailability) 70 % Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H
Vd (Volume of distribution) 4.10 L/kg Lombardo F, Berellini G, Obach RS
CL (Clearance) 1.70 mL/min/kg Lombardo F, Berellini G, Obach RS
fu (Fraction unbound in plasma) 0.70 % Lombardo F, Berellini G, Obach RS
t_half (Half-life) 38 hours Lombardo F, Berellini G, Obach RS

Predicted pharmacokinetic/toxicological properties (PK-AZ):

PropertyDescriptionValueUnitConfidenceSimilarity
azlogd74 LogD at pH 7.4 1.258 High 0.84
caco2-efflux Caco-2 efflux ratio (BA/AB) 35.645 High 0.84
caco2-intrinsic-papp Caco-2 intrinsic apparent permeability 5.140 10^-6 cm/s High 0.84
dh-clint Dog hepatocyte intrinsic clearance 1.387 uL/min/10^6 cells High 0.84
dppb Dog plasma protein binding (% unbound) 55.560 % High 0.84
fcs-ppb Fetal calf serum protein binding (% unbound) 53.680 % High 0.84
herg hERG pIC50 4.305 pIC50 High 0.84
hh-clint Human hepatocyte intrinsic clearance 1.096 uL/min/10^6 cells High 0.84
hlm-clint Human liver microsomal intrinsic clearance 3.673 uL/min/mg protein High 0.84
hppb Human plasma protein binding (% unbound) 58.720 % High 0.84
kinase-safety-class ACVR2B,CAMK2D,CDK5,EIF2AK3,GRK2,ITK,MAP2K6,NTRK2,PDK1,PDK2,PDK4,PRKDC 12
mdck-mdr1-bcrp-efflux MDCK-MDR1-BCRP efflux ratio 8.414 High 1
mdck-mdr1-efflux MDCK-MDR1 efflux ratio 21.330 High 0.84
mh-clint Mouse hepatocyte intrinsic clearance 4.018 High 0.84
mppb Mouse plasma protein binding (% unbound) 42.630 High 0.84
nih-mdck-mdr1-efflux NIH MDCK-MDR1 efflux ratio 37.757 High 0.84
pfas-class PFAS structural alert (1 = True, 0 = False) 0
pld-class Phospholipidosis risk class (1 = positive, 0 = negative) 1 High 1
pppb Pig plasma protein binding (% unbound) 54.080 % High 0.84
rat-kpuu-brain Rat brain Kpuu 0.010 % High 1
rh-clint Rat hepatocyte intrinsic clearance 1.791 uL/min/10^6 cells High 0.84
rh-fuinc Rat hepatocyte fraction unbound in incubation 77.010 % High 0.84
rppb Rat plasma protein binding (% unbound) 50 % High 0.84
solubility-dd Solubility at pH 7.4 in DMSO 824.138 uM High 0.84

Approvals:

DateAgencyCompanyOrphan
Oct. 24, 1975 FDA EUROHLTH INTL SARL

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Cardioactive drug level increased 1603.91 11.13 395 95646 1989 90530417
Bradycardia 1410.39 11.13 957 95084 82890 90449516
International normalised ratio increased 1100.92 11.13 663 95378 46653 90485753
Toxicity to various agents 943.42 11.13 1333 94708 286513 90245893
Atrial fibrillation 824.87 11.13 854 95187 132757 90399649
Drug interaction 812.13 11.13 1216 94825 275237 90257169
Cardiac failure congestive 758.24 11.13 711 95330 97983 90434423
Cardiac failure 551.57 11.13 629 95412 108867 90423539
Hyperkalaemia 508.29 11.13 473 95568 64491 90467915
Acute kidney injury 460.69 11.13 1035 95006 319352 90213054
Ventricular tachycardia 402.92 11.13 277 95764 24431 90507975
Drug ineffective 334.52 11.13 600 95441 1383698 89148708
Synovitis 319.67 11.13 6 96035 329746 90202660
Renal failure 310.27 11.13 523 95518 130484 90401922
Systemic lupus erythematosus 299.31 11.13 22 96019 361874 90170532
Hand deformity 293.11 11.13 4 96037 296358 90236048
Pulmonary hypertension 284.18 11.13 284 95757 42239 90490167
Hypotension 278.62 11.13 867 95174 324530 90207876
Atrial tachycardia 275.01 11.13 132 95909 5858 90526548
Infusion related reaction 274.97 11.13 54 95987 416726 90115680
Glossodynia 273.57 11.13 17 96024 321762 90210644
Torsade de pointes 266.08 11.13 178 95863 15004 90517402
Joint swelling 260.30 11.13 104 95937 503196 90029210
Myocardial infarction 253.45 11.13 425 95616 105547 90426859
Right ventricular failure 252.70 11.13 189 95852 19016 90513390
Dehydration 252.43 11.13 604 95437 193843 90338563
Dyspnoea 247.75 11.13 1687 94354 879268 89653138
Gastrointestinal haemorrhage 238.93 11.13 379 95662 89869 90442537
Arthropathy 238.31 11.13 49 95992 366193 90166213
Melaena 237.31 11.13 235 95806 34562 90497844
Sinus bradycardia 234.65 11.13 172 95869 16780 90515626
Off label use 233.56 11.13 515 95526 1101737 89430669
Drug intolerance 232.20 11.13 92 95949 447499 90084907
Subarachnoid haemorrhage 230.69 11.13 174 95867 17730 90514676
Wound 230.18 11.13 26 96015 302954 90229452
Contraindicated product administered 229.85 11.13 33 96008 320106 90212300
Bradyarrhythmia 227.82 11.13 89 95952 2372 90530034
Pulmonary arterial hypertension 217.01 11.13 197 95844 25990 90506416
Duodenal ulcer perforation 214.50 11.13 4 96037 221284 90311122
Treatment failure 214.33 11.13 33 96008 303895 90228511
Therapeutic product effect decreased 212.91 11.13 23 96018 277548 90254858
Helicobacter infection 212.54 11.13 6 96035 226844 90305562
Cardiospasm 211.77 11.13 93 95948 3353 90529053
Rheumatoid arthritis 211.55 11.13 61 95980 362553 90169853
Palmoplantar keratoderma 210.20 11.13 93 95948 3414 90528992
Syncope 195.12 11.13 433 95608 132230 90400176
Hepatic enzyme increased 193.95 11.13 70 95971 360666 90171740
Pruritus genital 192.88 11.13 95 95946 4463 90527943
Psoriatic arthropathy 191.24 11.13 13 96028 228322 90304084
Drug hypersensitivity 189.14 11.13 130 95911 463479 90068927
Stomatitis 188.80 11.13 32 96009 274666 90257740
Sleep terror 188.78 11.13 93 95948 4371 90528035
Fibromyalgia 187.73 11.13 7 96034 206262 90326144
Product complaint 186.91 11.13 137 95904 13363 90519043
Hypersensitivity 184.81 11.13 128 95913 454549 90077857
Rash 180.87 11.13 357 95684 795743 89736663
Pain 177.03 11.13 509 95532 995832 89536574
Atrioventricular block 175.61 11.13 112 95929 8703 90523703
Musculoskeletal stiffness 174.55 11.13 49 95992 296483 90235923
Carotid artery occlusion 171.38 11.13 98 95943 6244 90526162
Irritable bowel syndrome 167.51 11.13 14 96027 207434 90324972
Rheumatoid factor positive 166.75 11.13 3 96038 171647 90360759
Impaired healing 159.34 11.13 28 96013 234171 90298235
Atrioventricular block complete 157.58 11.13 109 95932 9702 90522704
Discomfort 154.78 11.13 49 95992 274286 90258120
Sinusitis 151.13 11.13 88 95953 343000 90189406
Tension headache 151.06 11.13 96 95945 7413 90524993
Swelling 150.03 11.13 134 95907 418924 90113482
Immunisation 149.98 11.13 64 95977 2149 90530257
Atrioventricular block first degree 149.64 11.13 100 95941 8411 90523995
Nasopharyngitis 149.60 11.13 127 95914 406977 90125429
Upper gastrointestinal haemorrhage 148.98 11.13 151 95890 22825 90509581
Cardiac arrest 145.90 11.13 335 95706 104600 90427806
Transient ischaemic attack 145.34 11.13 203 95838 42973 90489433
Arthralgia 145.31 11.13 388 95653 778134 89754272
Anaemia 141.17 11.13 742 95299 352060 90180346
Type 2 diabetes mellitus 138.91 11.13 24 96017 203220 90329186
Hypervolaemia 138.08 11.13 172 95869 32585 90499821
Cerebrovascular accident 137.39 11.13 362 95679 123171 90409235
Arrhythmia 135.05 11.13 194 95847 42138 90490268
Blood cholesterol increased 134.85 11.13 28 96013 207984 90324422
Palpitations 132.54 11.13 381 95660 136347 90396059
Death 130.47 11.13 879 95162 455672 90076734
Anosmia 129.73 11.13 97 95944 9751 90522655
Alopecia 129.43 11.13 203 95838 494868 90037538
Cardioactive drug level above therapeutic 127.37 11.13 30 96011 120 90532286
Facial pain 124.86 11.13 107 95934 13075 90519331
Subdural haematoma 123.96 11.13 118 95923 16527 90515879
Atrioventricular block second degree 123.54 11.13 70 95971 4382 90528024
Sleep disorder 119.74 11.13 31 96010 197999 90334407
Blister 117.18 11.13 62 95979 254936 90277470
Urticaria 115.52 11.13 97 95944 312637 90219769
Product use issue 113.89 11.13 109 95932 329810 90202596
Mobility decreased 112.25 11.13 63 95978 250671 90281735
Hypoaesthesia 111.77 11.13 101 95940 314109 90218297
Nodal rhythm 111.51 11.13 49 95992 1769 90530637
Cerebral haemorrhage 111.28 11.13 159 95882 34363 90498043
Hyponatraemia 110.50 11.13 352 95689 133186 90399220
Ill-defined disorder 109.78 11.13 30 96011 184861 90347545
Hallucination 109.24 11.13 226 95815 65733 90466673
Therapeutic product effect incomplete 106.92 11.13 36 96005 193860 90338546
Joint range of motion decreased 104.56 11.13 11 96030 135632 90396774
Electrocardiogram ST segment depression 102.78 11.13 56 95985 3247 90529159
Hypoxia 102.68 11.13 233 95808 72166 90460240
Asthma 102.56 11.13 65 95976 242095 90290311
Presyncope 101.80 11.13 146 95895 31659 90500747
Pain of skin 101.19 11.13 104 95937 15978 90516428
Infection 100.86 11.13 142 95899 361952 90170454
Dizziness 100.37 11.13 1009 95032 588275 89944131
Wheezing 99.33 11.13 65 95976 238015 90294391
Cardiomegaly 99.02 11.13 111 95930 18814 90513592
Gastrointestinal disorder 98.04 11.13 77 95964 256610 90275796
Ventricular fibrillation 97.88 11.13 96 95945 13948 90518458
Drug level increased 97.13 11.13 133 95908 27629 90504777
Paraesthesia 96.99 11.13 74 95967 250252 90282154
Haematoma 96.48 11.13 159 95882 38889 90493517
Lower gastrointestinal haemorrhage 96.30 11.13 78 95963 8814 90523592
Atrial flutter 95.19 11.13 84 95957 10674 90521732
Oedema peripheral 94.65 11.13 530 95511 257385 90275021
Diplopia 93.65 11.13 133 95908 28581 90503825
Electrocardiogram QT prolonged 92.72 11.13 224 95817 72232 90460174
Nodal arrhythmia 92.68 11.13 39 96002 1264 90531142
International normalised ratio abnormal 92.23 11.13 55 95986 3790 90528616
Cardioactive drug level decreased 91.92 11.13 21 96020 71 90532335
Obesity 91.33 11.13 5 96036 105502 90426904
Orthopnoea 89.31 11.13 67 95974 6768 90525638
Blood creatinine increased 89.17 11.13 273 95768 101113 90431293
International normalised ratio decreased 89.11 11.13 58 95983 4666 90527740
Lip dry 86.72 11.13 5 96036 100950 90431456
Overdose 86.67 11.13 364 95677 157345 90375061
Haemorrhage intracranial 86.39 11.13 93 95948 15069 90517337
Ventricular extrasystoles 85.75 11.13 87 95954 13163 90519243
Hypoglycaemia 85.20 11.13 212 95829 69636 90462770
C-reactive protein abnormal 84.99 11.13 16 96025 127413 90404993
Fall 82.93 11.13 827 95214 480983 90051423
Sinus node dysfunction 81.95 11.13 58 95983 5354 90527052
Pleural effusion 80.02 11.13 281 95760 111710 90420696
Blindness 79.29 11.13 118 95923 26450 90505956
Bursitis 78.82 11.13 21 96020 131633 90400773
Muscle twitching 78.78 11.13 112 95929 24090 90508316
Psoriasis 78.76 11.13 29 96012 147725 90384681
Wound infection 78.59 11.13 10 96031 106392 90426014
Maternal exposure during pregnancy 78.49 11.13 165 95876 359898 90172508
Blood urea increased 78.06 11.13 126 95915 30287 90502119
Asthenia 77.79 11.13 886 95155 532865 89999541
Ischaemic stroke 77.25 11.13 106 95935 22060 90510346
Pericarditis 77.15 11.13 104 95937 270047 90262359
Heart rate increased 77.00 11.13 279 95762 112623 90419783
Osteoarthritis 76.91 11.13 57 95984 195673 90336733
Cardiogenic shock 76.38 11.13 111 95930 24357 90508049
Lower respiratory tract infection 76.24 11.13 92 95949 250567 90281839
Prothrombin time prolonged 76.06 11.13 71 95970 9701 90522705
BRASH syndrome 76.05 11.13 38 96003 1841 90530565
Epistaxis 75.58 11.13 230 95811 84895 90447511
Product use in unapproved indication 75.04 11.13 152 95889 336084 90196322
Respiratory failure 74.40 11.13 285 95756 118133 90414273
Vasculitis 73.84 11.13 105 95936 22588 90509818
Grip strength decreased 72.67 11.13 7 96034 92569 90439837
Liver injury 71.90 11.13 46 95995 170521 90361885
Blood glucose increased 71.54 11.13 243 95798 95003 90437403
Sciatica 71.42 11.13 11 96030 101371 90431035
Hypercholesterolaemia 70.95 11.13 11 96030 100881 90431525
Tricuspid valve incompetence 70.74 11.13 88 95953 16643 90515763
Tachyarrhythmia 70.65 11.13 53 95988 5353 90527053
Blood potassium increased 70.48 11.13 98 95943 20651 90511755
Loss of consciousness 70.39 11.13 315 95726 139923 90392483
Dyspnoea exertional 69.58 11.13 201 95840 72087 90460319
Abdominal wall haematoma 67.79 11.13 43 95998 3309 90529097
Injection site reaction 67.17 11.13 9 96032 92071 90440335
Abdominal discomfort 66.62 11.13 270 95771 477058 90055348
Fluid retention 66.38 11.13 225 95816 87866 90444540
Ejection fraction decreased 66.34 11.13 108 95933 26145 90506261
Mitral valve incompetence 65.73 11.13 99 95942 22425 90509981
Musculoskeletal pain 64.57 11.13 52 95989 171199 90361207
Supraventricular tachycardia 64.43 11.13 83 95958 16253 90516153
Hypertension 64.36 11.13 258 95783 457274 90075132
Renal injury 64.00 11.13 66 95975 10177 90522229
C-reactive protein increased 63.63 11.13 59 95982 181330 90351076
Weight increased 63.08 11.13 229 95812 417698 90114708
Ischaemic contracture of the left ventricle 62.82 11.13 17 96024 131 90532275
Injection site pain 62.72 11.13 55 95986 173644 90358762
Ventricular arrhythmia 62.42 11.13 45 95996 4276 90528130
Metabolic acidosis 61.70 11.13 163 95878 55513 90476893
Renal impairment 61.58 11.13 248 95793 105173 90427233
Activated partial thromboplastin time prolonged 61.19 11.13 57 95984 7768 90524638
Pulmonary oedema 61.09 11.13 174 95867 61906 90470500
Inflammation 60.42 11.13 60 95981 178532 90353874
Autoimmune disorder 59.72 11.13 6 96035 76738 90455668
Peripheral venous disease 59.35 11.13 9 96032 83912 90448494
Arthritis 59.19 11.13 54 95987 167261 90365145
Haemoglobin decreased 58.82 11.13 332 95709 161624 90370782
Rectal haemorrhage 58.57 11.13 207 95834 82537 90449869
Cardiac failure chronic 57.94 11.13 48 95993 5598 90526808
Pruritus 56.71 11.13 339 95702 541186 89991220
Night sweats 56.67 11.13 33 96008 128733 90403673
Knee arthroplasty 56.42 11.13 10 96031 83172 90449234
Coagulopathy 56.41 11.13 94 95947 23195 90509211
Multiple organ dysfunction syndrome 56.37 11.13 180 95861 68156 90464250
Heart rate irregular 56.19 11.13 96 95945 24172 90508234
Chest pain 56.04 11.13 551 95490 319094 90213312
Lower limb fracture 55.99 11.13 11 96030 85002 90447404
Heart rate decreased 55.63 11.13 153 95888 53352 90479054
Eye pruritus 54.70 11.13 105 95936 28922 90503484
Alveolitis 54.32 11.13 36 96005 2985 90529421
Hip arthroplasty 54.29 11.13 8 96033 76200 90456206
Embolic stroke 53.39 11.13 40 96001 4032 90528374
Bundle branch block right 53.15 11.13 45 95996 5408 90526998
Tinnitus 52.74 11.13 131 95910 42971 90489435
Tachycardia 52.56 11.13 316 95725 157357 90375049
Cardiac failure acute 52.46 11.13 64 95977 11865 90520541
Dry mouth 52.38 11.13 71 95970 183988 90348418
Hypovolaemia 51.94 11.13 65 95976 12366 90520040
Disorientation 51.81 11.13 132 95909 43982 90488424
Red blood cell sedimentation rate increased 51.71 11.13 12 96029 82583 90449823
Extrasystoles 51.71 11.13 45 95996 5612 90526794
Haematemesis 51.70 11.13 112 95929 33614 90498792
Lip swelling 51.15 11.13 121 95920 38489 90493917
Lethargy 49.99 11.13 164 95877 62975 90469431
Hyperthyroidism 49.94 11.13 78 95963 18232 90514174
Electrocardiogram abnormal 49.81 11.13 58 95983 10240 90522166
Prescribed overdose 49.00 11.13 21 96020 97604 90434802
Injection site erythema 48.17 11.13 22 96019 98480 90433926
Electrocardiogram ST segment abnormal 48.05 11.13 24 96017 1162 90531244
Muscle spasms 47.96 11.13 124 95917 251759 90280647
Drug therapeutic incompatibility 47.32 11.13 11 96030 41 90532365
Vomiting 47.20 11.13 1130 94911 787163 89745243
Haemorrhage 46.92 11.13 171 95870 69198 90463208
Unevaluable event 46.64 11.13 146 95895 54702 90477704
Dyspepsia 46.41 11.13 87 95954 198073 90334333
Joint stiffness 45.67 11.13 13 96028 78029 90454377
Foot deformity 45.55 11.13 5 96036 59646 90472760
Coronary artery disease 45.22 11.13 106 95935 33517 90498889
Blood pressure decreased 45.19 11.13 178 95863 74717 90457689
Respiratory distress 45.18 11.13 116 95925 38830 90493576
Shock haemorrhagic 44.86 11.13 60 95981 12185 90520221
Angioedema 44.79 11.13 161 95880 64715 90467691
Cardiac disorder 44.38 11.13 147 95894 56725 90475681
Xanthopsia 43.69 11.13 14 96027 204 90532202
Urine output decreased 43.51 11.13 60 95981 12543 90519863
Prothrombin time shortened 43.04 11.13 28 96013 2250 90530156
Acute respiratory failure 42.91 11.13 121 95920 42797 90489609
Nail disorder 42.54 11.13 6 96035 59061 90473345
Intentional product use issue 41.89 11.13 106 95935 216786 90315620
Cardiomyopathy 41.70 11.13 76 95965 20130 90512276
Left ventricular failure 41.55 11.13 43 95998 6657 90525749
Pulmonary fibrosis 41.33 11.13 32 96009 107471 90424935
Rash papular 41.30 11.13 76 95965 20279 90512127
Febrile neutropenia 41.21 11.13 65 95976 158284 90374122
Epilepsy 40.76 11.13 18 96023 82188 90450218
Myocardial ischaemia 40.71 11.13 61 95980 13753 90518653
Transfusion 40.25 11.13 69 95972 17419 90514987
Anuria 40.24 11.13 63 95978 14755 90517651
Accidental overdose 40.08 11.13 91 95950 28182 90504224
Brain natriuretic peptide increased 39.90 11.13 40 96001 5965 90526441
Disturbance in attention 39.68 11.13 125 95916 46984 90485422
Electrocardiogram PR prolongation 39.41 11.13 19 96022 851 90531555
Colitis ulcerative 39.26 11.13 8 96033 60258 90472148
Gait inability 39.19 11.13 59 95982 146397 90386009
Lactic acidosis 38.99 11.13 130 95911 50333 90482073
Toxic epidermal necrolysis 38.89 11.13 98 95943 32430 90499976
Cardio-respiratory arrest 38.85 11.13 151 95890 62989 90469417
Depression 38.84 11.13 175 95866 300426 90231980
Atrioventricular dissociation 38.67 11.13 13 96028 222 90532184
Taste disorder 38.41 11.13 9 96032 61537 90470869
Liver function test increased 38.40 11.13 21 96020 84834 90447572
Contusion 38.29 11.13 137 95904 251079 90281327
Loss of personal independence in daily activities 38.22 11.13 53 95988 136052 90396354
Potentiating drug interaction 38.15 11.13 38 96003 5624 90526782
Cerebral infarction 38.14 11.13 86 95955 26510 90505896
Cor pulmonale 38.14 11.13 25 96016 2035 90530371
Sopor 37.96 11.13 82 95959 24562 90507844
Road traffic accident 37.74 11.13 35 96006 107591 90424815
Pulmonary arterial pressure increased 37.52 11.13 32 96009 3884 90528522
Bundle branch block left 37.46 11.13 44 95997 7841 90524565
Calcium deficiency 37.10 11.13 21 96020 1312 90531094
Electrocardiogram QT shortened 36.83 11.13 12 96029 185 90532221
X-ray abnormal 36.82 11.13 3 96038 45421 90486985
Cardioactive drug level below therapeutic 36.63 11.13 7 96034 6 90532400
Left ventricular dysfunction 36.59 11.13 60 95981 14609 90517797
Prescribed underdose 36.30 11.13 17 96024 75002 90457404
Injury 36.16 11.13 99 95942 197250 90335156
Injection site bruising 36.10 11.13 6 96035 52301 90480105
Pulse absent 36.01 11.13 38 96003 6017 90526389
Stupor 35.48 11.13 36 96005 5446 90526960
Injection site pruritus 35.38 11.13 7 96034 53827 90478579
Myelosuppression 35.15 11.13 7 96034 53584 90478822
Ischaemic cardiomyopathy 35.00 11.13 26 96015 2587 90529819
Fear 34.91 11.13 63 95978 16559 90515847
Occult blood positive 34.77 11.13 31 96010 3992 90528414
Onychomadesis 34.75 11.13 4 96037 45994 90486412
Exostosis 34.73 11.13 7 96034 53127 90479279
Neutropenia 34.71 11.13 122 95919 224782 90307624
Haematuria 34.44 11.13 98 95943 34839 90497567
Hypokalaemia 34.11 11.13 247 95794 130869 90401537
Pain in jaw 33.91 11.13 120 95921 47865 90484541
Hypocoagulable state 33.56 11.13 21 96020 1578 90530828
Joint dislocation 33.38 11.13 4 96037 44578 90487828
Drug-induced liver injury 33.32 11.13 28 96013 90290 90442116
Visual impairment 33.09 11.13 247 95794 132118 90400288
Therapeutic response decreased 32.88 11.13 28 96013 89701 90442705
Leukopenia 32.73 11.13 35 96006 100675 90431731
Pulmonary congestion 32.65 11.13 67 95974 19366 90513040
Laryngitis 32.52 11.13 7 96034 50746 90481660
Coagulation time prolonged 32.49 11.13 21 96020 1669 90530737
Erythrodermic psoriasis 32.34 11.13 18 96023 1088 90531318
Cellulitis 32.33 11.13 186 95855 91151 90441255
Left atrial dilatation 32.25 11.13 22 96019 1914 90530492
Device related infection 32.21 11.13 79 95962 25707 90506699
Chronic obstructive pulmonary disease 32.03 11.13 159 95882 73670 90458736
Multiple sclerosis relapse 31.96 11.13 8 96033 52297 90480109
Wrong product administered 31.90 11.13 40 96001 7625 90524781
Dilatation atrial 31.79 11.13 22 96019 1959 90530447
Injection site swelling 31.45 11.13 12 96029 59827 90472579
Decreased appetite 31.38 11.13 567 95474 375973 90156433
Oxygen consumption increased 31.29 11.13 31 96010 4558 90527848
Cognitive disorder 31.20 11.13 151 95890 69256 90463150
Sleep disorder due to a general medical condition 31.17 11.13 5 96036 44733 90487673
Suicidal ideation 31.00 11.13 20 96021 73835 90458571
Ear infection 30.53 11.13 18 96023 69757 90462649
Cardiac pacemaker insertion 30.47 11.13 30 96011 4377 90528029
Mental status changes 30.09 11.13 110 95931 44569 90487837
Sepsis 30.04 11.13 307 95734 179507 90352899
Nausea 29.94 11.13 1450 94591 1108866 89423540
Osteoporosis 29.78 11.13 35 96006 96496 90435910
Immunodeficiency 29.75 11.13 5 96036 43229 90489177
Dyschromatopsia 29.73 11.13 15 96026 742 90531664
Hypomagnesaemia 29.58 11.13 94 95947 35494 90496912
Catheter management 29.48 11.13 25 96016 3011 90529395
Atrial thrombosis 29.32 11.13 22 96019 2223 90530183
Liver function test abnormal 29.19 11.13 119 95922 50726 90481680
Lung transplant 29.07 11.13 27 96014 3665 90528741
Frequent bowel movements 28.97 11.13 12 96029 56923 90475483
Fluid replacement 28.96 11.13 14 96027 631 90531775
Mitral valve stenosis 28.90 11.13 18 96023 1341 90531065
Adverse event 28.87 11.13 50 95991 117368 90415038
Neuropathy peripheral 28.78 11.13 64 95977 136906 90395500
Oliguria 28.61 11.13 45 95996 10579 90521827
Drug abuse 28.61 11.13 27 96014 82320 90450086
Haemoptysis 28.60 11.13 89 95952 33231 90499175
Puncture site haemorrhage 28.60 11.13 12 96029 386 90532020
Chromatopsia 28.60 11.13 13 96028 509 90531897
Electrocardiogram QRS complex prolonged 28.46 11.13 37 96004 7311 90525095
Haemorrhagic disorder 28.32 11.13 16 96025 996 90531410
Haemodialysis 27.76 11.13 40 96001 8707 90523699
Disability 27.41 11.13 5 96036 40740 90491666
Illness 27.18 11.13 28 96013 81941 90450465
Pregnancy 27.15 11.13 16 96025 62031 90470375
Retroperitoneal haemorrhage 27.15 11.13 24 96017 3056 90529350
Medication error 27.14 11.13 168 95873 84484 90447922
Acute myocardial infarction 27.05 11.13 90 95951 34800 90497606
Back injury 26.85 11.13 8 96033 46614 90485792
Dialysis 26.47 11.13 45 95996 11284 90521122
Drug monitoring procedure not performed 26.32 11.13 14 96027 773 90531633
Supraventricular extrasystoles 26.08 11.13 30 96011 5227 90527179
Dilatation ventricular 26.06 11.13 21 96020 2355 90530051
Blood loss anaemia 26.00 11.13 42 95999 10098 90522308
Gastrooesophageal reflux disease 25.81 11.13 90 95951 166247 90366159
Circulatory collapse 25.67 11.13 71 95970 24833 90507573
Hypochromic anaemia 25.55 11.13 20 96021 2151 90530255
Congestive hepatopathy 25.48 11.13 23 96018 3010 90529396
General physical health deterioration 25.41 11.13 247 95794 354868 90177538
Drug level above therapeutic 25.27 11.13 31 96010 5778 90526628
Ventricular hypertrophy 25.17 11.13 24 96017 3367 90529039
Live birth 25.14 11.13 28 96013 79079 90453327
Ecchymosis 24.99 11.13 46 95995 12277 90520129
Superinfection 24.97 11.13 23 96018 3089 90529317
Iron deficiency anaemia 24.92 11.13 68 95973 23594 90508812
Toxic nodular goitre 24.91 11.13 7 96034 63 90532343
Haematocrit decreased 24.89 11.13 99 95942 41733 90490673
White blood cell count decreased 24.88 11.13 92 95949 167017 90365389
Dermatitis exfoliative 24.83 11.13 30 96011 5506 90526900
Puncture site haematoma 24.81 11.13 7 96034 64 90532342
Splenic injury 24.36 11.13 9 96032 205 90532201
Faeces discoloured 24.21 11.13 63 95978 21257 90511149
Transplant evaluation 24.11 11.13 16 96025 1330 90531076
Orthostatic hypotension 24.10 11.13 98 95943 41729 90490677
Aspartate aminotransferase increased 24.00 11.13 189 95852 102748 90429658
Therapy non-responder 23.98 11.13 70 95971 136634 90395772
Electrocardiogram repolarisation abnormality 23.79 11.13 16 96025 1360 90531046
Ascites 23.76 11.13 107 95934 47633 90484773
Lupus-like syndrome 23.74 11.13 11 96030 48835 90483571
Cyanosis 23.66 11.13 59 95982 19396 90513010
Anhedonia 23.59 11.13 43 95998 11388 90521018
Subcutaneous haematoma 23.59 11.13 18 96023 1865 90530541
Central nervous system injury 23.35 11.13 8 96033 145 90532261
Inappropriate schedule of product administration 23.35 11.13 81 95960 149852 90382554
Hypochromasia 23.21 11.13 10 96031 344 90532062
Chronic kidney disease 23.14 11.13 110 95931 50081 90482325
Neutrophil count decreased 23.09 11.13 25 96016 71507 90460899
Head injury 22.90 11.13 79 95962 31109 90501297
Confusional state 22.82 11.13 553 95488 385652 90146754
Blood bilirubin increased 22.82 11.13 99 95942 43371 90489035
Electrolyte imbalance 22.81 11.13 66 95975 23679 90508727
No adverse event 22.79 11.13 23 96018 67959 90464447
Feeling abnormal 22.22 11.13 273 95768 166962 90365444
Finger deformity 22.21 11.13 4 96037 32893 90499513
Pain in extremity 22.11 11.13 340 95701 450189 90082217
Kussmaul respiration 21.73 11.13 9 96032 280 90532126
Oxygen saturation decreased 21.67 11.13 191 95850 107292 90425114
Drug tolerance decreased 21.49 11.13 4 96037 32126 90500280
Leukocytosis 21.47 11.13 77 95964 30913 90501493
Choroidal haemorrhage 21.35 11.13 6 96035 54 90532352
Coma scale abnormal 21.28 11.13 28 96013 5598 90526808
Catheter site erythema 21.10 11.13 26 96015 4868 90527538
Intentional self-injury 21.08 11.13 3 96038 29331 90503075
Cardiac murmur 20.90 11.13 54 95987 18140 90514266
Coronary arterial stent insertion 20.89 11.13 20 96021 2820 90529586
Mitral valve disease 20.56 11.13 19 96022 2563 90529843
Hypophagia 20.54 11.13 84 95957 35853 90496553
Abdominal tenderness 20.43 11.13 36 96005 9288 90523118
Aortic valve calcification 20.42 11.13 11 96030 623 90531783
Blood culture positive 20.36 11.13 26 96015 5046 90527360
Anticoagulation drug level above therapeutic 20.35 11.13 17 96024 2005 90530401
Brain stem haemorrhage 20.23 11.13 12 96029 819 90531587
Lung disorder 20.10 11.13 86 95955 149797 90382609
Depressed level of consciousness 20.02 11.13 139 95902 72645 90459761
Cholecystitis 20.01 11.13 51 95990 16989 90515417
Paralysis 19.79 11.13 40 96001 11438 90520968
Blood alkaline phosphatase increased 19.76 11.13 102 95939 47977 90484429
Ventricular dysfunction 19.72 11.13 22 96019 3709 90528697
Upper respiratory tract infection 19.52 11.13 70 95971 128248 90404158
Hypersensitivity vasculitis 19.41 11.13 23 96018 4136 90528270
Vision blurred 19.22 11.13 190 95851 110103 90422303
Cardioversion 19.18 11.13 14 96027 1356 90531050
Staphylococcal sepsis 18.99 11.13 35 96006 9348 90523058
Cardiac valve disease 18.99 11.13 24 96017 4611 90527795
Concomitant disease progression 18.90 11.13 17 96024 2215 90530191
Gastrointestinal ulcer haemorrhage 18.89 11.13 12 96029 926 90531480
Peripheral swelling 18.85 11.13 316 95725 412790 90119616
Hypoglycaemic seizure 18.84 11.13 10 96031 550 90531856
Sudden death 18.78 11.13 38 96003 10871 90521535
Product dose omission issue 18.76 11.13 208 95833 291479 90240927
Psychotic symptom 18.74 11.13 17 96024 2239 90530167
Muscle spasticity 18.70 11.13 7 96034 35315 90497091
Unresponsive to stimuli 18.64 11.13 85 95956 38036 90494370
Hyponatraemic syndrome 18.61 11.13 10 96031 564 90531842
Congenital clavicular agenesis 18.57 11.13 6 96035 90 90532316
Malignant neoplasm progression 18.54 11.13 55 95986 106815 90425591
Conduction disorder 18.33 11.13 15 96026 1720 90530686
Diverticulum 18.30 11.13 40 96001 12073 90520333
Walking distance test abnormal 18.30 11.13 10 96031 583 90531823
Right ventricular systolic pressure increased 18.27 11.13 10 96031 585 90531821
Oropharyngeal pain 18.08 11.13 62 95979 115125 90417281
Right ventricular hypertrophy 17.83 11.13 11 96030 806 90531600
Aortic valve incompetence 17.76 11.13 28 96013 6596 90525810
Prerenal failure 17.69 11.13 16 96025 2099 90530307
Pulseless electrical activity 17.68 11.13 33 96008 8899 90523507
Fatigue 17.53 11.13 1023 95018 1153000 89379406
Sinus arrest 17.49 11.13 16 96025 2130 90530276
Neck pain 17.45 11.13 62 95979 113901 90418505
Aortic stenosis 17.29 11.13 27 96014 6309 90526097
Premature delivery 17.18 11.13 84 95957 38678 90493728
Dementia 17.14 11.13 60 95981 23801 90508605
Electrocardiogram R on T phenomenon 16.98 11.13 4 96037 16 90532390
Herpes zoster 16.94 11.13 48 95993 94596 90437810
Catheter site infection 16.71 11.13 25 96016 5629 90526777
Right ventricular dilatation 16.52 11.13 14 96027 1685 90530721
Labelled drug-drug interaction medication error 16.46 11.13 43 95998 14539 90517867
Muscle haemorrhage 16.44 11.13 19 96022 3327 90529079
Hypoglycaemic coma 16.44 11.13 18 96023 2972 90529434
Rheumatic heart disease 16.26 11.13 4 96037 20 90532386
Angina unstable 16.20 11.13 28 96013 7115 90525291
Microcytic anaemia 16.01 11.13 20 96021 3798 90528608
Basal ganglia haemorrhage 15.98 11.13 10 96031 751 90531655
Anaphylactic reaction 15.95 11.13 44 95997 87480 90444926
Rhythm idioventricular 15.95 11.13 8 96033 391 90532015
Thyrotoxic crisis 15.93 11.13 12 96029 1219 90531187
Paracentesis 15.85 11.13 11 96030 984 90531422
Chronic sinusitis 15.84 11.13 3 96038 23799 90508607
Dry eye 15.82 11.13 23 96018 57908 90474498
Chorea 15.79 11.13 15 96026 2095 90530311
Electrocardiogram change 15.59 11.13 10 96031 784 90531622
Pyroglutamic acidosis 15.52 11.13 12 96029 1268 90531138
Venous pressure jugular increased 15.49 11.13 9 96032 591 90531815
Procedural pain 15.47 11.13 8 96033 33352 90499054
Catheter site rash 15.30 11.13 10 96031 810 90531596
Haemarthrosis 15.29 11.13 20 96021 3974 90528432
Mouth swelling 15.27 11.13 24 96017 5638 90526768
Cardiac resynchronisation therapy 15.12 11.13 4 96037 28 90532378
Pericardial effusion 15.04 11.13 78 95963 36755 90495651
Duodenal ulcer 14.96 11.13 32 96009 9520 90522886
Dizziness postural 14.96 11.13 31 96010 9022 90523384
Pyrexia 14.91 11.13 561 95480 659924 89872482
Acute pulmonary oedema 14.89 11.13 32 96009 9548 90522858
N-terminal prohormone brain natriuretic peptide increased 14.86 11.13 17 96024 2945 90529461
Hemiparesis 14.86 11.13 70 95971 31749 90500657
Respiratory acidosis 14.84 11.13 29 96012 8090 90524316
Cardiorenal syndrome 14.75 11.13 11 96030 1101 90531305
Catheter site pruritus 14.68 11.13 15 96026 2287 90530119
Hyperhidrosis 14.59 11.13 214 95827 136091 90396315
Insomnia 14.59 11.13 257 95784 333217 90199189
Cardiopulmonary failure 14.55 11.13 20 96021 4168 90528238
Leg amputation 14.50 11.13 15 96026 2322 90530084
Walking aid user 14.38 11.13 10 96031 35496 90496910
Tachycardia foetal 14.36 11.13 6 96035 191 90532215
Congestive cardiomyopathy 14.35 11.13 27 96014 7327 90525079
Intracardiac thrombus 14.30 11.13 15 96026 2359 90530047
Cardiopulmonary bypass 14.26 11.13 3 96038 6 90532400
Rales 14.26 11.13 43 95998 15784 90516622
Therapy partial responder 14.20 11.13 3 96038 22040 90510366
Heart sounds abnormal 14.15 11.13 9 96032 696 90531710
Protein total 14.13 11.13 4 96037 37 90532369
Haemorrhagic stroke 14.13 11.13 25 96016 6471 90525935
Jaundice 14.08 11.13 70 95971 32447 90499959
Gastric ulcer 14.02 11.13 62 95979 27386 90505020
Blood pressure immeasurable 13.90 11.13 12 96029 1480 90530926
Ventricular asystole 13.87 11.13 5 96036 106 90532300
Exercise tolerance decreased 13.84 11.13 27 96014 7524 90524882
Blood sodium decreased 13.82 11.13 62 95979 27551 90504855
Acidosis 13.81 11.13 37 96004 12699 90519707
Hypovolaemic shock 13.78 11.13 26 96015 7068 90525338
Drug dispensed to wrong patient 13.77 11.13 7 96034 352 90532054
Altered state of consciousness 13.74 11.13 68 95973 31464 90500942
Laryngeal pain 13.71 11.13 20 96021 4402 90528004
Blood creatinine 13.69 11.13 5 96036 110 90532296
Fungal infection 13.67 11.13 15 96026 42646 90489760
Right atrial dilatation 13.54 11.13 9 96032 750 90531656
Cutaneous vasculitis 13.53 11.13 26 96015 7167 90525239
Eosinophilic granulomatosis with polyangiitis 13.51 11.13 15 96026 2515 90529891
Azotaemia 13.51 11.13 22 96019 5326 90527080
Duodenal ulcer haemorrhage 13.38 11.13 15 96026 2541 90529865
Cardiac output decreased 13.33 11.13 10 96031 1010 90531396
Euphoric mood 13.32 11.13 22 96019 5387 90527019
Ventricular failure 13.29 11.13 7 96034 379 90532027
Adams-Stokes syndrome 13.27 11.13 4 96037 47 90532359
Headache 13.21 11.13 764 95277 861982 89670424
Retroperitoneal haematoma 13.11 11.13 17 96024 3351 90529055
Anisocytosis 13.10 11.13 9 96032 792 90531614
Cerebellar haematoma 13.05 11.13 7 96034 393 90532013
Intensive care 12.98 11.13 11 96030 1323 90531083
Infected skin ulcer 12.98 11.13 15 96026 2627 90529779
Acquired haemophilia 12.91 11.13 10 96031 1059 90531347
Cytomegalovirus infection 12.91 11.13 6 96035 26596 90505810
Cerebellar haemorrhage 12.84 11.13 12 96029 1641 90530765
Serratia infection 12.78 11.13 10 96031 1075 90531331
Chromaturia 12.72 11.13 47 95994 19140 90513266
Flat anterior chamber of eye 12.63 11.13 4 96037 56 90532350
Cardiac ablation 12.53 11.13 12 96029 1692 90530714
Glomerular filtration rate decreased 12.53 11.13 43 95998 16889 90515517
Shock 12.49 11.13 62 95979 28716 90503690
Rheumatoid nodule 12.48 11.13 3 96038 20163 90512243
Femoral neck fracture 12.41 11.13 31 96010 10202 90522204
Catheter site discharge 12.38 11.13 14 96027 2395 90530011
Ischaemia 12.33 11.13 21 96020 5274 90527132
Conjunctival haemorrhage 12.32 11.13 18 96023 3966 90528440
Hyperchloraemia 12.26 11.13 9 96032 879 90531527
Feeling hot 12.24 11.13 42 95999 77966 90454440
Spontaneous haematoma 12.21 11.13 10 96031 1148 90531258
Concomitant disease aggravated 12.03 11.13 33 96008 11485 90520921
Catheterisation cardiac 12.00 11.13 20 96021 4936 90527470
Haematoma evacuation 11.94 11.13 5 96036 160 90532246
Blood potassium decreased 11.88 11.13 89 95952 47638 90484768
Catheter placement 11.85 11.13 14 96027 2510 90529896
Hepatic steatosis 11.82 11.13 13 96028 36932 90495474
Urinary tract disorder 11.82 11.13 17 96024 3694 90528712
Thoracic vertebral fracture 11.82 11.13 21 96020 5453 90526953
Migraine 11.75 11.13 137 95904 190255 90342151
Venous haemorrhage 11.74 11.13 6 96035 305 90532101
Multi-organ disorder 11.67 11.13 13 96028 2187 90530219
Lymphocyte count decreased 11.59 11.13 12 96029 35038 90497368
Underdose 11.54 11.13 25 96016 53992 90478414
Prothrombin level increased 11.47 11.13 6 96035 320 90532086
Refusal of treatment by relative 11.46 11.13 6 96035 321 90532085
Electrocardiogram ST-T change 11.43 11.13 9 96032 976 90531430
Colitis 11.42 11.13 37 96004 69905 90462501
Neuralgia 11.33 11.13 10 96031 31490 90500916
Somnolence 11.33 11.13 296 95745 208788 90323618
Oxygen saturation abnormal 11.32 11.13 18 96023 4270 90528136
Ear pain 11.28 11.13 28 96013 57674 90474732
Hereditary haemorrhagic telangiectasia 11.26 11.13 4 96037 81 90532325
Adverse reaction 11.22 11.13 9 96032 29703 90502703
Diabetic metabolic decompensation 11.14 11.13 12 96029 1945 90530461

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Cardioactive drug level increased 935.86 11.43 273 80801 1464 42538797
Bradycardia 761.59 11.43 874 80200 84610 42455651
Cardiac failure congestive 680.88 11.43 826 80248 84776 42455485
International normalised ratio increased 639.70 11.43 610 80464 47558 42492703
Atrial fibrillation 464.17 11.43 898 80176 138695 42401566
Ventricular tachycardia 415.54 11.43 390 80684 29770 42510491
Off label use 344.85 11.43 427 80647 637908 41902353
Hyperkalaemia 258.92 11.43 511 80563 79947 42460314
Drug ineffective 238.98 11.43 530 80544 629667 41910594
Cardiac failure 236.52 11.43 584 80490 106272 42433989
Toxicity to various agents 230.84 11.43 954 80120 228182 42312079
Myocardial infarction 191.25 11.43 594 80480 123415 42416846
Atrial tachycardia 187.99 11.43 110 80964 4030 42536231
Cardiospasm 161.92 11.43 77 80997 1830 42538431
Gastrointestinal haemorrhage 159.86 11.43 478 80596 97248 42443013
Product complaint 153.36 11.43 111 80963 5866 42534395
Palmoplantar keratoderma 143.95 11.43 75 80999 2179 42538082
Hypotension 135.74 11.43 896 80178 256735 42283526
Pruritus genital 135.57 11.43 76 80998 2563 42537698
Dyspnoea 134.32 11.43 1357 79717 441264 42098997
Drug abuse 133.51 11.43 20 81054 104751 42435510
Drug interaction 131.36 11.43 913 80161 266086 42274175
Sleep terror 128.27 11.43 76 80998 2850 42537411
Product use in unapproved indication 125.74 11.43 100 80974 184356 42355905
Venous pressure jugular increased 124.35 11.43 49 81025 723 42539538
Carotid artery occlusion 119.41 11.43 83 80991 4111 42536150
Tension headache 117.47 11.43 76 80998 3338 42536923
Febrile neutropenia 116.45 11.43 109 80965 185594 42354667
Melaena 111.36 11.43 235 80839 38511 42501750
Acute kidney injury 111.14 11.43 1126 79948 366211 42174050
Immunisation 107.43 11.43 51 81023 1207 42539054
Cardiac arrest 105.69 11.43 450 80624 108870 42431391
Facial pain 104.50 11.43 77 80997 4183 42536078
Dizziness 100.80 11.43 814 80260 248440 42291821
Atrial flutter 97.45 11.43 141 80933 17110 42523151
Subarachnoid haemorrhage 96.30 11.43 128 80946 14344 42525917
Anosmia 93.31 11.43 78 80996 5098 42535163
Neutropenia 92.38 11.43 148 80926 199283 42340978
Right ventricular failure 90.44 11.43 101 80973 9454 42530807
Cardioactive drug level above therapeutic 89.70 11.43 21 81053 36 42540225
Product dose omission issue 89.43 11.43 97 80977 154268 42385993
Ischaemic cardiomyopathy 87.19 11.43 83 80991 6439 42533822
Arrhythmia 86.56 11.43 218 80856 40099 42500162
Nodal rhythm 84.24 11.43 47 81027 1570 42538691
Transient ischaemic attack 76.19 11.43 186 80888 33553 42506708
Muscle twitching 73.52 11.43 101 80973 11679 42528582
Ventricular extrasystoles 72.09 11.43 107 80967 13283 42526978
Atrioventricular block 70.15 11.43 89 80985 9526 42530735
Pulmonary hypertension 70.10 11.43 145 80929 23424 42516837
Prothrombin time prolonged 68.06 11.43 87 80987 9382 42530879
Pain of skin 67.37 11.43 80 80994 8000 42532261
Renal failure 66.69 11.43 485 80589 143241 42397020
Cardiac murmur 62.99 11.43 98 80976 12677 42527584
Heart rate increased 62.48 11.43 233 80841 53022 42487239
Congestive cardiomyopathy 62.17 11.43 80 80994 8684 42531577
Bradyarrhythmia 60.38 11.43 46 81028 2629 42537632
Palpitations 60.23 11.43 223 80851 50574 42489687
Atrioventricular block complete 60.02 11.43 90 80984 11274 42528987
Injection site pain 59.42 11.43 18 81056 57780 42482481
Xanthopsia 59.39 11.43 19 81055 145 42540116
Cardioactive drug level decreased 59.04 11.43 16 81058 62 42540199
Drug hypersensitivity 58.03 11.43 62 81012 99327 42440934
Tricuspid valve incompetence 57.25 11.43 87 80987 11026 42529235
Torsade de pointes 57.16 11.43 76 80998 8518 42531743
Inappropriate schedule of product administration 56.92 11.43 59 81015 95843 42444418
Mitral valve incompetence 55.70 11.43 107 80967 16382 42523879
Rash 55.43 11.43 305 80769 276649 42263612
Therapeutic product effect incomplete 54.14 11.43 34 81040 70905 42469356
Pericarditis 53.97 11.43 94 80980 13350 42526911
Left ventricular dysfunction 53.63 11.43 86 80988 11415 42528846
Cardiomyopathy 53.43 11.43 115 80959 19095 42521166
Pulmonary arterial hypertension 52.83 11.43 80 80994 10107 42530154
Coronary artery disease 52.52 11.43 222 80852 53498 42486763
Syncope 52.30 11.43 346 80728 99060 42441201
International normalised ratio decreased 51.50 11.43 53 81021 4519 42535742
Blood urea increased 51.28 11.43 158 80916 32635 42507626
Myelosuppression 50.88 11.43 8 81066 40453 42499808
Heart rate irregular 50.40 11.43 101 80973 15949 42524312
Cardiomegaly 49.68 11.43 103 80971 16663 42523598
Dehydration 49.27 11.43 448 80626 141319 42398942
Confusional state 49.12 11.43 511 80563 167086 42373175
Cerebrovascular accident 48.02 11.43 333 80741 96827 42443434
Neuropathy peripheral 47.65 11.43 75 80999 101778 42438483
Asthenia 46.48 11.43 771 80303 280022 42260239
Subdural haematoma 45.42 11.43 121 80953 23017 42517244
Ventricular fibrillation 45.13 11.43 143 80931 29980 42510281
Eye pruritus 44.78 11.43 79 80995 11333 42528928
Electrocardiogram ST segment depression 44.75 11.43 39 81035 2698 42537563
Atrioventricular block first degree 44.09 11.43 58 81016 6433 42533828
Cardiac failure chronic 43.68 11.43 71 81003 9530 42530731
Ejection fraction decreased 42.84 11.43 115 80959 21972 42518289
Left ventricular failure 42.69 11.43 55 81019 5976 42534285
Drug intolerance 41.78 11.43 55 81019 80369 42459892
Neutrophil count decreased 41.14 11.43 36 81038 63379 42476882
Malignant neoplasm progression 40.84 11.43 91 80983 108309 42431952
Sinus node dysfunction 40.70 11.43 48 81026 4764 42535497
Mucosal inflammation 40.02 11.43 22 81052 49352 42490909
Blood creatinine increased 39.93 11.43 351 80723 109652 42430609
Diplopia 39.63 11.43 106 80968 20210 42520051
Bundle branch block left 39.62 11.43 55 81019 6421 42533840
Blindness 39.40 11.43 98 80976 17880 42522381
Blood lactic acid 38.94 11.43 17 81057 329 42539932
Nodal arrhythmia 38.49 11.43 23 81051 876 42539385
Drug ineffective for unapproved indication 38.25 11.43 20 81054 46143 42494118
Nasopharyngitis 38.20 11.43 63 81011 83933 42456328
Chest pain 37.87 11.43 419 80655 139111 42401150
Treatment failure 37.75 11.43 38 81036 62586 42477675
Coagulopathy 37.69 11.43 110 80964 22052 42518209
Supraventricular tachycardia 37.67 11.43 77 80997 12331 42527930
Conduction disorder 37.43 11.43 34 81040 2484 42537777
Visual impairment 36.71 11.43 171 80903 42942 42497319
Haematoma 36.59 11.43 127 80947 27896 42512365
Haematuria 36.55 11.43 211 80863 57588 42482673
Electrocardiogram ST segment abnormal 36.54 11.43 21 81053 743 42539518
Ventricular arrhythmia 36.45 11.43 52 81022 6227 42534034
Hallucination 35.76 11.43 209 80865 57298 42482963
Anuria 35.53 11.43 72 81002 11460 42528801
Sleep disorder 35.40 11.43 24 81050 48071 42492190
Orthostatic hypotension 35.22 11.43 133 80941 30437 42509824
Neuralgia 34.79 11.43 4 81070 25643 42514618
Lip swelling 34.76 11.43 97 80977 18956 42521305
Blood potassium increased 34.44 11.43 95 80979 18441 42521820
Rash papular 34.34 11.43 72 81002 11739 42528522
Leukopenia 34.05 11.43 56 81018 74690 42465571
Lethargy 33.55 11.43 177 80897 46713 42493548
Oedema peripheral 33.50 11.43 401 80673 135675 42404586
Stomatitis 33.34 11.43 28 81046 50301 42489960
Amnesia 32.99 11.43 124 80950 28313 42511948
Cardiac failure acute 32.75 11.43 77 80997 13556 42526705
Lip discolouration 32.50 11.43 13 81061 200 42540061
Electrocardiogram QRS complex prolonged 32.02 11.43 47 81027 5776 42534485
Drug dependence 31.88 11.43 8 81066 29086 42511175
N-terminal prohormone brain natriuretic peptide increased 31.82 11.43 36 81038 3417 42536844
Cardioactive drug level below therapeutic 31.60 11.43 6 81068 0 42540261
Psoriatic arthropathy 31.25 11.43 5 81069 24962 42515299
Hyperthyroidism 31.24 11.43 78 80996 14263 42525998
Cardiorenal syndrome 31.02 11.43 20 81054 873 42539388
Vasculitis 30.99 11.43 91 80983 18303 42521958
International normalised ratio abnormal 30.38 11.43 35 81039 3388 42536873
White blood cell count decreased 30.24 11.43 108 80966 110288 42429973
Haemorrhage intracranial 29.87 11.43 86 80988 17106 42523155
Oedema 29.79 11.43 185 80889 51816 42488445
Product use issue 29.26 11.43 64 81010 76687 42463574
Pyrexia 28.61 11.43 553 80521 393489 42146772
Cardiac disorder 28.61 11.43 175 80899 48757 42491504
Depression 28.52 11.43 112 80962 111251 42429010
Appendicitis 28.51 11.43 3 81071 20610 42519651
Epistaxis 28.40 11.43 221 80853 66605 42473656
Somnolence 28.38 11.43 155 80919 140950 42399311
Infusion related reaction 28.21 11.43 45 81029 60761 42479500
Drug resistance 28.13 11.43 15 81059 34233 42506028
Jugular vein distension 27.99 11.43 17 81057 667 42539594
Dilatation atrial 27.79 11.43 27 81047 2148 42538113
Heart rate decreased 27.58 11.43 140 80934 36392 42503869
Orthopnoea 27.33 11.43 42 81032 5375 42534886
Colitis ulcerative 27.17 11.43 8 81066 26167 42514094
Drug-induced liver injury 26.98 11.43 20 81054 38253 42502008
Loss of personal independence in daily activities 26.97 11.43 33 81041 49783 42490478
Cytokine release syndrome 26.85 11.43 27 81047 44500 42495761
Cytomegalovirus infection 26.76 11.43 14 81060 32292 42507969
Ischaemic stroke 26.67 11.43 98 80976 22135 42518126
Rheumatoid arthritis 26.44 11.43 25 81049 42415 42497846
Hypersensitivity 26.24 11.43 62 81012 72308 42467953
Fall 26.21 11.43 607 80467 233913 42306348
Blood glucose increased 26.13 11.43 234 80840 73465 42466796
Drug reaction with eosinophilia and systemic symptoms 25.96 11.43 25 81049 42050 42498211
Pulmonary embolism 25.96 11.43 128 80946 119484 42420777
Chronic obstructive pulmonary disease 25.87 11.43 207 80867 62907 42477354
Dilatation ventricular 25.80 11.43 28 81046 2538 42537723
Myasthenic syndrome 25.15 11.43 17 81057 804 42539457
Therapy partial responder 25.08 11.43 4 81070 20017 42520244
Tachycardia 24.91 11.43 298 80776 100789 42439472
Sinusitis 24.90 11.43 32 81042 47260 42493001
Faeces discoloured 24.78 11.43 80 80994 16934 42523327
Psoriasis 24.46 11.43 34 81040 48570 42491691
Cardiac death 24.23 11.43 19 81055 1133 42539128
Electrocardiogram PR prolongation 24.23 11.43 18 81056 990 42539271
Creatinine renal clearance decreased 24.10 11.43 32 81042 3581 42536680
Lymphadenopathy 24.09 11.43 17 81057 33348 42506913
Anhedonia 23.89 11.43 48 81026 7592 42532669
Coronary artery bypass 23.85 11.43 37 81037 4773 42535488
Ventricular hypertrophy 23.82 11.43 37 81037 4779 42535482
Eczema 23.78 11.43 18 81056 34068 42506193
Fluid retention 23.75 11.43 121 80953 31498 42508763
COVID-19 23.51 11.43 127 80947 115821 42424440
Upper gastrointestinal haemorrhage 23.50 11.43 117 80957 30182 42510079
Urticaria 23.36 11.43 68 81006 73968 42466293
Cardiac output decreased 23.35 11.43 18 81056 1047 42539214
Blood pressure increased 23.33 11.43 107 80967 101821 42438440
Benign gastrointestinal neoplasm 23.20 11.43 9 81065 127 42540134
Hepatic cytolysis 23.19 11.43 11 81063 26833 42513428
Pruritus 22.88 11.43 239 80835 188532 42351729
Polymerase chain reaction 22.59 11.43 8 81066 86 42540175
Cardiogenic shock 22.46 11.43 130 80944 35510 42504751
Pleural effusion 22.45 11.43 283 80791 96883 42443378
Injury 22.40 11.43 93 80981 22223 42518038
Muscle spasms 22.37 11.43 86 80988 85958 42454303
Acute myocardial infarction 22.35 11.43 188 80886 57977 42482284
Intentional overdose 22.11 11.43 40 81034 51416 42488845
Arthralgia 22.06 11.43 267 80807 204971 42335290
No adverse event 22.04 11.43 25 81049 38996 42501265
Procalcitonin abnormal 22.00 11.43 12 81062 383 42539878
Influenza 21.96 11.43 54 81020 62121 42478140
International normalised ratio fluctuation 21.92 11.43 19 81055 1305 42538956
Atrioventricular block second degree 21.88 11.43 33 81041 4154 42536107
Prohormone brain natriuretic peptide increased 21.80 11.43 8 81066 96 42540165
Extrasystoles 21.75 11.43 33 81041 4176 42536085
Brain natriuretic peptide increased 21.73 11.43 43 81031 6727 42533534
Prostate cancer 21.71 11.43 32 81042 44611 42495650
Peripheral embolism 21.39 11.43 17 81057 1034 42539227
Dyspnoea exertional 21.39 11.43 166 80908 49982 42490279
Concomitant disease progression 21.22 11.43 25 81049 2478 42537783
Cardio-respiratory arrest 21.21 11.43 187 80887 58449 42481812
Pancytopenia 21.19 11.43 134 80940 117609 42422652
Diabetic ketoacidosis 21.18 11.43 8 81066 22359 42517902
Constipation 21.11 11.43 202 80872 162089 42378172
Suicidal ideation 21.08 11.43 37 81037 48124 42492137
Foetal tachyarrhythmia 21.07 11.43 4 81070 0 42540261
Renal impairment 20.95 11.43 310 80764 109918 42430343
Peripheral coldness 20.88 11.43 48 81026 8327 42531934
Electrocardiogram abnormal 20.87 11.43 54 81020 10091 42530170
Myasthenia gravis 20.72 11.43 3 81071 16134 42524127
Malaise 20.66 11.43 539 80535 211617 42328644
Asthma 20.57 11.43 56 81018 62258 42478003
Illness 20.36 11.43 11 81063 24919 42515342
BRASH syndrome 20.27 11.43 21 81053 1804 42538457
Electrocardiogram repolarisation abnormality 20.25 11.43 16 81058 965 42539296
Aspergillus infection 20.21 11.43 3 81071 15834 42524427
Rash maculo-papular 20.14 11.43 25 81049 37478 42502783
Infection 19.93 11.43 128 80946 111940 42428321
Eosinophilia 19.78 11.43 20 81054 32879 42507382
Synovitis 19.75 11.43 3 81071 15564 42524697
Frequent bowel movements 19.71 11.43 8 81066 21399 42518862
Angina unstable 19.63 11.43 57 81017 11391 42528870
Electrocardiogram T wave amplitude decreased 19.62 11.43 11 81063 371 42539890
Pulmonary arterial pressure increased 19.48 11.43 19 81055 1519 42538742
Renal oncocytoma 19.31 11.43 9 81065 204 42540057
Colitis 19.30 11.43 37 81037 46535 42493726
Adrenal insufficiency 19.25 11.43 6 81068 18918 42521343
Cognitive disorder 19.21 11.43 121 80953 34051 42506210
Intentional self-injury 19.12 11.43 3 81071 15199 42525062
Musculoskeletal stiffness 19.00 11.43 52 81022 57713 42482548
Haematemesis 18.92 11.43 110 80964 30089 42510172
Sudden death 18.86 11.43 72 81002 16557 42523704
Disturbance in attention 18.85 11.43 109 80965 29757 42510504
Supraventricular extrasystoles 18.74 11.43 30 81044 3976 42536285
Cyanosis 18.66 11.43 67 81007 14964 42525297
Erythema 18.47 11.43 126 80948 108667 42431594
Palmar-plantar erythrodysaesthesia syndrome 18.45 11.43 8 81066 20574 42519687
Cerebral haemorrhage 18.32 11.43 132 80942 38834 42501427
Cerebral infarction 17.91 11.43 111 80963 31058 42509203
Oesophageal achalasia 17.85 11.43 11 81063 443 42539818
Arthropathy 17.78 11.43 18 81056 29579 42510682
Burning feet syndrome 17.78 11.43 7 81067 103 42540158
Feeling abnormal 17.75 11.43 207 80867 69579 42470682
Anaphylactic reaction 17.68 11.43 34 81040 42709 42497552
Abnormal loss of weight 17.63 11.43 33 81041 4954 42535307
Blood pressure decreased 17.59 11.43 179 80895 58153 42482108
Erectile dysfunction 17.58 11.43 13 81061 24900 42515361
Enzyme induction 17.51 11.43 6 81068 58 42540203
Hypophosphataemia 17.46 11.43 9 81065 20936 42519325
Subdural haemorrhage 17.46 11.43 27 81047 3474 42536787
Haemorrhage 17.39 11.43 184 80890 60379 42479882
Congestive hepatopathy 17.30 11.43 22 81052 2360 42537901
Right atrial dilatation 17.27 11.43 10 81064 359 42539902
Brain natriuretic peptide 16.95 11.43 5 81069 28 42540233
Lymphopenia 16.91 11.43 10 81064 21553 42518708
Herpes zoster 16.90 11.43 30 81044 38847 42501414
Drug withdrawal syndrome 16.89 11.43 10 81064 21539 42518722
Haematocrit decreased 16.84 11.43 119 80955 34789 42505472
Completed suicide 16.73 11.43 111 80963 96354 42443907
Pneumocystis jirovecii pneumonia 16.69 11.43 14 81060 25167 42515094
Tricuspid valve sclerosis 16.66 11.43 5 81069 30 42540231
PO2 decreased 16.66 11.43 18 81056 1623 42538638
Sinus bradycardia 16.59 11.43 64 81010 14789 42525472
Pain in extremity 16.52 11.43 195 80879 150409 42389852
Withdrawal syndrome 16.31 11.43 4 81070 14771 42525490
Suicide attempt 16.31 11.43 40 81034 46060 42494201
Ventricular dysfunction 16.17 11.43 30 81044 4473 42535788
Nephrogenic systemic fibrosis 16.08 11.43 26 81048 3475 42536786
Chills 15.94 11.43 109 80965 93957 42446304
Irritability 15.90 11.43 18 81056 28110 42512151
Hospitalisation 15.85 11.43 80 80994 74250 42466011
Disease progression 15.76 11.43 186 80888 143470 42396791
Therapeutic response decreased 15.69 11.43 29 81045 36983 42503278
Ischaemic hepatitis 15.64 11.43 20 81054 2157 42538104
Oliguria 15.61 11.43 46 81028 9267 42530994
Transaminases increased 15.57 11.43 24 81050 32861 42507400
Emotional distress 15.33 11.43 66 81008 16027 42524234
Atrial thrombosis 15.32 11.43 21 81053 2423 42537838
Haemothorax 15.31 11.43 32 81042 5204 42535057
Sleep disorder due to a general medical condition 15.31 11.43 7 81067 17446 42522815
Carotid artery disease 15.30 11.43 13 81061 869 42539392
Atrial enlargement 15.28 11.43 12 81062 717 42539544
Graft versus host disease 15.28 11.43 3 81071 12922 42527339
Blood test abnormal 15.25 11.43 3 81071 12903 42527358
Encephalomalacia 15.14 11.43 14 81060 1047 42539214
Infective exacerbation of chronic obstructive airways disease 15.12 11.43 19 81055 2014 42538247
Respiratory failure 15.02 11.43 334 80740 127798 42412463
Left ventricular dilatation 14.99 11.43 13 81061 893 42539368
Embolic stroke 14.97 11.43 31 81043 5009 42535252
Haemophagocytic lymphohistiocytosis 14.94 11.43 8 81066 18214 42522047
Cerebral haematoma 14.93 11.43 33 81041 5577 42534684
Neoplasm progression 14.88 11.43 20 81054 28980 42511281
Myocardial ischaemia 14.79 11.43 70 81004 17692 42522569
Acute hepatic failure 14.74 11.43 7 81067 17066 42523195
Diverticulum intestinal haemorrhagic 14.66 11.43 23 81051 2996 42537265
Limited symptom panic attack 14.53 11.43 5 81069 49 42540212
Aortic stenosis 14.48 11.43 43 81031 8702 42531559
Transplant rejection 14.39 11.43 4 81070 13584 42526677
Incorrect route of product administration 14.35 11.43 15 81059 24290 42515971
Polypectomy 14.34 11.43 11 81063 635 42539626
Fungal infection 14.30 11.43 10 81064 19712 42520549
Drug level increased 14.25 11.43 92 80982 26108 42514153
Toxic epidermal necrolysis 14.19 11.43 18 81056 26732 42513529
Nightmare 14.15 11.43 16 81058 24996 42515265
Mitral valve replacement 14.04 11.43 7 81067 185 42540076
Obstructive airways disorder 13.83 11.43 16 81058 24743 42515518
Prothrombin level decreased 13.81 11.43 14 81060 1172 42539089
Bundle branch block 13.78 11.43 13 81061 997 42539264
Morning glory syndrome 13.73 11.43 3 81071 3 42540258
PCO2 decreased 13.71 11.43 17 81057 1777 42538484
Presyncope 13.67 11.43 81 80993 22306 42517955
Angioedema 13.61 11.43 132 80942 42345 42497916
Headache 13.58 11.43 349 80725 239020 42301241
Pulmonary oedema 13.53 11.43 158 80916 53114 42487147
Neurotoxicity 13.52 11.43 15 81059 23636 42516625
Pulseless electrical activity 13.51 11.43 41 81033 8396 42531865
Joint swelling 13.51 11.43 75 80999 67947 42472314
Hyperphosphataemia 13.45 11.43 4 81070 13000 42527261
Dyspnoea paroxysmal nocturnal 13.44 11.43 16 81058 1604 42538657
Gastric mucosal lesion 13.42 11.43 11 81063 699 42539562
Pain 13.36 11.43 359 80715 244489 42295772
Thrombosis 13.36 11.43 76 80998 68435 42471826
Tremor 13.30 11.43 119 80955 96810 42443451
Skin exfoliation 13.22 11.43 38 81036 41515 42498746
Dystonia 13.11 11.43 4 81070 12786 42527475
Migraine 13.07 11.43 88 80986 25326 42514935
Mitral valve sclerosis 12.96 11.43 7 81067 219 42540042
Urine leukocyte esterase positive 12.96 11.43 9 81065 445 42539816
Head injury 12.91 11.43 75 80999 20507 42519754
Thrombotic microangiopathy 12.85 11.43 6 81068 14776 42525485
Electrocardiogram ST-T change 12.82 11.43 10 81064 592 42539669
Tumour lysis syndrome 12.82 11.43 14 81060 22217 42518044
Acne 12.72 11.43 5 81069 13639 42526622
Hypoalbuminaemia 12.58 11.43 7 81067 15603 42524658
Cerebral atrophy 12.54 11.43 29 81045 5050 42535211
Device issue 12.52 11.43 5 81069 13504 42526757
Intracardiac thrombus 12.47 11.43 19 81055 2413 42537848
Injection site erythema 12.46 11.43 12 81062 20183 42520078
Occult blood positive 12.43 11.43 26 81048 4231 42536030
Blood pressure fluctuation 12.40 11.43 20 81054 26888 42513373
Hepatic enzyme increased 12.39 11.43 45 81029 45739 42494522
Loss of consciousness 12.20 11.43 245 80829 92109 42448152
Calculus bladder 12.14 11.43 14 81060 1356 42538905
Multiple sclerosis relapse 12.08 11.43 6 81068 14258 42526003
Fear 12.05 11.43 47 81027 10918 42529343
Dissociation 12.04 11.43 24 81050 3774 42536487
COVID-19 pneumonia 12.04 11.43 14 81060 21599 42518662
Bronchiectasis 11.96 11.43 10 81064 18009 42522252
Hallucination, olfactory 11.80 11.43 7 81067 263 42539998
Haemodynamic test abnormal 11.73 11.43 4 81070 38 42540223
Hypogammaglobulinaemia 11.69 11.43 4 81070 11887 42528374
Medication error 11.60 11.43 105 80969 33049 42507212
Lymphocyte count decreased 11.60 11.43 22 81052 27787 42512474
Encephalopathy 11.60 11.43 40 81034 41293 42498968
Posterior reversible encephalopathy syndrome 11.47 11.43 5 81069 12816 42527445
Bronchopulmonary aspergillosis 11.46 11.43 12 81062 19417 42520844
Heparin-induced thrombocytopenia 11.46 11.43 33 81041 6564 42533697

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Cardioactive drug level increased 2263.63 11.19 606 152604 3276 110432813
Bradycardia 2061.30 11.19 1713 151497 153804 110282285
International normalised ratio increased 1572.93 11.19 1151 152059 85621 110350468
Cardiac failure congestive 1267.88 11.19 1289 151921 149711 110286378
Atrial fibrillation 1123.95 11.19 1484 151726 228158 110207931
Toxicity to various agents 983.77 11.19 2099 151111 478456 109957633
Drug interaction 843.16 11.19 2023 151187 498160 109937929
Ventricular tachycardia 800.26 11.19 616 152594 49393 110386696
Hyperkalaemia 725.37 11.19 917 152293 134879 110301210
Cardiac failure 648.68 11.19 1029 152181 186597 110249492
Acute kidney injury 510.86 11.19 1982 151228 633448 109802641
Off label use 488.86 11.19 833 152377 1499352 108936737
Myocardial infarction 476.34 11.19 910 152300 191173 110244916
Drug ineffective 440.85 11.19 906 152304 1519634 108916455
Atrial tachycardia 425.75 11.19 222 152988 8956 110427133
Hypotension 385.23 11.19 1590 151620 522259 109913830
Gastrointestinal haemorrhage 364.21 11.19 746 152464 164772 110271317
Cardiospasm 356.68 11.19 162 153048 4805 110431284
Synovitis 341.30 11.19 8 153202 274084 110162005
Product complaint 339.09 11.19 222 152988 13750 110422339
Palmoplantar keratoderma 337.97 11.19 160 153050 5227 110430862
Dyspnoea 337.22 11.19 2650 150560 1104222 109331867
Melaena 319.78 11.19 434 152776 68323 110367766
Pruritus genital 317.60 11.19 163 153047 6359 110429730
Renal failure 315.60 11.19 854 152356 225720 110210369
Sleep terror 309.79 11.19 161 153049 6449 110429640
Right ventricular failure 304.45 11.19 267 152943 25687 110410402
Subarachnoid haemorrhage 304.03 11.19 283 152927 29419 110406670
Torsade de pointes 292.56 11.19 246 152964 22354 110413735
Hand deformity 286.17 11.19 3 153207 218503 110217586
Carotid artery occlusion 284.81 11.19 173 153037 9392 110426697
Infusion related reaction 281.22 11.19 89 153121 381073 110055016
Drug intolerance 277.50 11.19 108 153102 406404 110029685
Pemphigus 276.31 11.19 4 153206 214566 110221523
Pulmonary hypertension 274.33 11.19 360 152850 54860 110381229
Dehydration 270.39 11.19 927 152283 278584 110157505
Systemic lupus erythematosus 266.94 11.19 23 153187 254315 110181774
Drug hypersensitivity 264.80 11.19 150 153060 453940 109982149
Tension headache 256.07 11.19 162 153048 9456 110426633
Bradyarrhythmia 248.06 11.19 126 153084 4808 110431281
Immunisation 241.86 11.19 108 153102 3075 110433014
Joint swelling 240.49 11.19 159 153051 442686 109993403
Psoriatic arthropathy 240.19 11.19 7 153203 196754 110239335
Syncope 238.77 11.19 719 152491 201817 110234272
Glossodynia 235.94 11.19 19 153191 221985 110214104
Stomatitis 232.30 11.19 46 153164 270196 110165893
Pulmonary arterial hypertension 231.91 11.19 255 152955 32313 110403776
Arthropathy 228.95 11.19 58 153152 287464 110148625
Anosmia 224.67 11.19 165 153045 12307 110423782
Arrhythmia 224.33 11.19 370 152840 69205 110366884
Nasopharyngitis 219.00 11.19 138 153072 394223 110041866
Rheumatoid arthritis 217.34 11.19 72 153138 299541 110136548
Transient ischaemic attack 216.79 11.19 348 152862 63634 110372455
Facial pain 215.30 11.19 175 153035 15164 110420925
Cardiac arrest 212.92 11.19 678 152532 196075 110240014
Treatment failure 211.18 11.19 61 153149 277173 110158916
Atrioventricular block 210.85 11.19 180 153030 16697 110419392
Atrioventricular block complete 208.73 11.19 193 153017 19889 110416200
Hypersensitivity 206.22 11.19 155 153055 403843 110032246
Fibromyalgia 205.30 11.19 7 153203 170902 110265187
Hepatic enzyme increased 201.82 11.19 96 153114 320796 110115293
Duodenal ulcer perforation 198.11 11.19 12 153198 177688 110258401
Rash 194.05 11.19 543 152667 820421 109615668
Helicobacter infection 192.05 11.19 16 153194 181861 110254228
Nodal rhythm 191.53 11.19 94 153116 3329 110432760
Therapeutic product effect decreased 189.34 11.19 52 153158 244264 110191825
Cardioactive drug level above therapeutic 189.26 11.19 48 153162 201 110435888
Wound 189.13 11.19 46 153164 234391 110201698
Atrial flutter 179.77 11.19 194 153016 24068 110412021
Muscle injury 179.67 11.19 3 153207 140804 110295285
Musculoskeletal stiffness 178.59 11.19 82 153128 279740 110156349
Irritable bowel syndrome 177.44 11.19 13 153197 164202 110271887
Sinusitis 175.74 11.19 96 153114 296592 110139497
Sinus bradycardia 173.14 11.19 209 153001 29274 110406815
Pain of skin 169.60 11.19 172 153038 19857 110416232
Product use in unapproved indication 169.36 11.19 223 152987 447154 109988935
Contraindicated product administered 169.25 11.19 66 153144 248201 110187888
Cerebrovascular accident 168.00 11.19 593 152617 180691 110255398
Impaired healing 165.88 11.19 35 153175 196682 110239407
Dizziness 164.80 11.19 1582 151628 696611 109739478
Ventricular extrasystoles 164.19 11.19 179 153031 22462 110413627
Arthralgia 162.56 11.19 546 152664 779086 109657003
Blood cholesterol increased 159.72 11.19 31 153179 184754 110251335
Rheumatoid factor positive 159.49 11.19 5 153205 131635 110304454
Pain 159.49 11.19 731 152479 954224 109481865
Sleep disorder 156.32 11.19 41 153169 198603 110237486
Palpitations 155.51 11.19 530 152680 158682 110277407
Electrocardiogram ST segment depression 152.97 11.19 95 153115 5366 110430723
Swelling 148.81 11.19 160 153050 350881 110085208
Therapeutic product effect incomplete 146.86 11.19 63 153147 223742 110212347
Hallucination 144.76 11.19 386 152824 101046 110335043
Urticaria 144.66 11.19 137 153073 318720 110117369
Subdural haematoma 139.85 11.19 210 153000 36244 110399845
Asthma 139.68 11.19 87 153123 250204 110185885
Muscle twitching 139.21 11.19 189 153021 29746 110406343
Upper gastrointestinal haemorrhage 138.61 11.19 249 152961 49847 110386242
Venous pressure jugular increased 136.16 11.19 56 153154 1296 110434793
Discomfort 133.77 11.19 65 153145 214642 110221447
Blood creatinine increased 132.28 11.19 553 152657 182336 110253753
Drug abuse 131.50 11.19 41 153169 177370 110258719
International normalised ratio decreased 130.68 11.19 101 153109 8135 110427954
Blood urea increased 130.68 11.19 256 152954 54701 110381388
Ventricular fibrillation 126.86 11.19 215 152995 41098 110394991
Blindness 126.22 11.19 200 153010 36159 110399930
Diplopia 125.98 11.19 216 152994 41678 110394411
Hypoaesthesia 125.77 11.19 150 153060 314073 110122016
Atrioventricular block first degree 123.82 11.19 124 153086 14101 110421988
Cardioactive drug level decreased 123.27 11.19 33 153177 178 110435911
Product use issue 122.42 11.19 151 153059 311544 110124545
Ill-defined disorder 122.22 11.19 33 153177 156820 110279269
Cardiomegaly 122.15 11.19 175 153035 28955 110407134
Wheezing 121.31 11.19 105 153105 255125 110180964
Febrile neutropenia 120.73 11.19 157 153053 316610 110119479
C-reactive protein abnormal 120.35 11.19 18 153192 129677 110306412
Haematoma 119.66 11.19 256 152954 58220 110377869
Heart rate increased 119.33 11.19 454 152756 143380 110292709
Injection site pain 118.46 11.19 49 153161 177873 110258216
Coronary artery disease 118.05 11.19 288 152922 71402 110364687
Tricuspid valve incompetence 117.55 11.19 155 153055 23718 110412371
Prothrombin time prolonged 117.46 11.19 132 153078 17129 110418960
Lip dry 117.10 11.19 5 153205 100078 110336011
Type 2 diabetes mellitus 116.09 11.19 50 153160 177182 110258907
Obesity 114.25 11.19 12 153198 113339 110322750
Sinus node dysfunction 114.05 11.19 97 153113 8950 110427139
Maternal exposure during pregnancy 113.85 11.19 111 153099 254772 110181317
Ischaemic cardiomyopathy 113.70 11.19 92 153118 7919 110428170
Mitral valve incompetence 112.49 11.19 181 153029 33148 110402941
Bursitis 111.83 11.19 22 153188 129896 110306193
Infection 111.78 11.19 207 153003 361993 110074096
Nodal arrhythmia 110.45 11.19 56 153154 2128 110433961
Atrioventricular block second degree 109.91 11.19 91 153119 8090 110427999
Joint range of motion decreased 108.36 11.19 19 153191 121813 110314276
Mobility decreased 107.67 11.19 102 153108 237320 110198769
Orthopnoea 107.01 11.19 102 153108 10919 110425170
Drug level increased 105.92 11.19 216 152994 47503 110388586
International normalised ratio abnormal 105.34 11.19 80 153130 6277 110429812
Hypervolaemia 105.22 11.19 220 152990 49240 110386849
Neutropenia 104.56 11.19 227 152983 374393 110061696
Xanthopsia 104.52 11.19 33 153177 342 110435747
Eye pruritus 103.87 11.19 173 153037 32602 110403487
Oedema peripheral 103.22 11.19 794 152416 327866 110108223
Gastrointestinal disorder 102.80 11.19 110 153100 241842 110194247
Vasculitis 102.70 11.19 181 153029 35692 110400397
Asthenia 101.67 11.19 1426 151784 687573 109748516
Ejection fraction decreased 101.56 11.19 194 153016 40686 110395403
Epistaxis 101.21 11.19 403 152807 129969 110306120
Musculoskeletal pain 96.18 11.19 68 153142 182955 110253134
Psoriasis 95.73 11.19 37 153173 139956 110296133
Cardiac failure chronic 94.63 11.19 106 153104 13705 110422384
Osteoarthritis 94.46 11.19 69 153141 182554 110253535
Cerebral haemorrhage 93.45 11.19 248 152962 64720 110371369
Dry mouth 92.90 11.19 84 153126 199864 110236225
Blister 92.61 11.19 107 153103 227269 110208820
Ischaemic stroke 91.85 11.19 187 153023 41076 110395013
Blood glucose increased 91.41 11.19 395 152815 132101 110303988
Myelosuppression 90.09 11.19 12 153198 94328 110341761
Chest pain 89.62 11.19 855 152355 375520 110060569
Blood potassium increased 89.10 11.19 163 153047 33086 110403003
Inflammation 88.80 11.19 82 153128 193156 110242933
Ventricular arrhythmia 87.92 11.19 88 153122 9999 110426090
BRASH syndrome 87.52 11.19 58 153152 3665 110432424
Haematuria 86.95 11.19 283 152927 82722 110353367
Cardiac murmur 86.21 11.19 136 153074 24492 110411597
Fluid retention 86.03 11.19 307 152903 94000 110342089
Dyspnoea exertional 85.91 11.19 328 152882 103732 110332357
Coagulopathy 85.89 11.19 181 153029 40730 110395359
Night sweats 85.84 11.19 39 153171 133944 110302145
Presyncope 85.44 11.19 201 153009 48686 110387403
Lip swelling 83.89 11.19 204 153006 50463 110385626
Wound infection 83.73 11.19 16 153194 96449 110339640
Muscle spasms 83.14 11.19 162 153048 277995 110158094
Lethargy 83.13 11.19 302 152908 93274 110342815
Paraesthesia 82.69 11.19 161 153049 276360 110159729
Grip strength decreased 82.06 11.19 8 153202 80166 110355923
Pleural effusion 81.56 11.19 472 152738 177237 110258852
Haemorrhage intracranial 81.43 11.19 145 153065 28824 110407265
Injection site reaction 81.18 11.19 13 153197 89057 110347032
Tachycardia 81.11 11.19 565 152645 226080 110210009
Hyponatraemia 81.10 11.19 548 152662 217105 110218984
Cardiogenic shock 79.57 11.19 216 152994 57122 110378967
Electrocardiogram ST segment abnormal 79.43 11.19 42 153168 1743 110434346
Renal impairment 79.12 11.19 489 152721 187956 110248133
Left ventricular failure 79.04 11.19 88 153122 11301 110424788
Cardiac failure acute 77.51 11.19 128 153082 23950 110412139
Rash papular 77.25 11.19 138 153072 27501 110408588
Left ventricular dysfunction 77.13 11.19 126 153084 23367 110412722
Heart rate irregular 77.08 11.19 156 153054 34118 110401971
Cardiomyopathy 77.08 11.19 154 153056 33371 110402718
Peripheral venous disease 75.06 11.19 13 153197 84104 110351985
Fall 74.95 11.19 1213 151997 602269 109833820
Disturbance in attention 73.82 11.19 221 152989 61774 110374315
Weight increased 73.57 11.19 315 152895 419329 110016760
Pruritus 73.35 11.19 488 152722 581072 109855017
Visual impairment 73.12 11.19 374 152836 134054 110302035
Hyperthyroidism 71.62 11.19 138 153072 29123 110406966
Arthritis 71.38 11.19 76 153134 167510 110268579
Respiratory failure 71.37 11.19 527 152683 214805 110221284
Congestive cardiomyopathy 71.06 11.19 93 153117 14126 110421963
Lower limb fracture 70.96 11.19 10 153200 75338 110360751
Inappropriate schedule of product administration 70.52 11.19 108 153102 203529 110232560
Alopecia 70.11 11.19 264 152946 364489 110071600
Loss of consciousness 69.43 11.19 488 152722 195818 110240271
Electrocardiogram abnormal 69.24 11.19 106 153104 18603 110417486
Bundle branch block left 68.65 11.19 87 153123 12801 110423288
Nail disorder 67.42 11.19 3 153207 57932 110378157
Anuria 67.34 11.19 121 153089 24220 110411869
Sciatica 67.30 11.19 22 153188 92377 110343712
Neuropathy peripheral 67.09 11.19 90 153120 179187 110256902
C-reactive protein increased 65.90 11.19 126 153084 217793 110218296
Hypercholesterolaemia 65.51 11.19 22 153188 90815 110345274
Embolic stroke 64.92 11.19 70 153140 8673 110427416
Colitis ulcerative 64.71 11.19 14 153196 77349 110358740
Extrasystoles 64.24 11.19 68 153142 8250 110427839
Lower respiratory tract infection 63.98 11.19 152 153058 242954 110193135
Red blood cell sedimentation rate increased 63.83 11.19 15 153195 78287 110357802
Hypertension 63.81 11.19 429 152781 509655 109926434
Heart rate decreased 63.56 11.19 255 152955 82501 110353588
Depression 63.40 11.19 226 152984 317109 110118980
Haematemesis 63.23 11.19 203 153007 58905 110377184
Haemorrhage 63.10 11.19 304 152906 106388 110329701
Product dose omission issue 61.77 11.19 233 152977 321549 110114540
Renal injury 60.94 11.19 100 153110 18613 110417476
Cardioactive drug level below therapeutic 60.88 11.19 12 153198 8 110436081
Loss of personal independence in daily activities 60.64 11.19 71 153139 149949 110286140
Drug-induced liver injury 59.98 11.19 47 153163 120020 110316069
Liver injury 59.93 11.19 72 153138 150341 110285748
Leukopenia 59.52 11.19 71 153139 148720 110287369
Electrocardiogram PR prolongation 59.19 11.19 35 153175 1808 110434281
Electrocardiogram QT prolonged 59.15 11.19 303 152907 108657 110327432
Lower gastrointestinal haemorrhage 59.14 11.19 98 153112 18388 110417701
Autoimmune disorder 58.69 11.19 10 153200 65473 110370616
Tinnitus 58.59 11.19 201 153009 60339 110375750
Anaemia 58.26 11.19 1073 152137 546013 109890076
Haemoglobin decreased 58.14 11.19 563 152647 248164 110187925
Knee arthroplasty 58.03 11.19 10 153200 64938 110371151
Ischaemic contracture of the left ventricle 57.42 11.19 17 153193 139 110435950
Acute myocardial infarction 57.19 11.19 249 152961 83528 110352561
Confusional state 56.62 11.19 938 152272 467742 109968347
Cardiac disorder 56.16 11.19 232 152978 76048 110360041
Cerebral infarction 55.42 11.19 178 153032 51660 110384429
Prescribed overdose 55.31 11.19 26 153184 87555 110348534
Overdose 55.04 11.19 530 152680 233264 110202825
Neutrophil count decreased 54.75 11.19 52 153158 120889 110315200
Supraventricular tachycardia 54.73 11.19 111 153099 24311 110411778
White blood cell count decreased 54.52 11.19 151 153059 229239 110206850
Hypoglycaemia 54.31 11.19 310 152900 115794 110320295
Unevaluable event 54.17 11.19 193 153017 59034 110377055
Dilatation atrial 54.16 11.19 44 153166 3808 110432281
Illness 54.08 11.19 23 153187 82148 110353941
Frequent bowel movements 53.78 11.19 16 153194 71374 110364715
Therapeutic response decreased 53.17 11.19 34 153176 96465 110339624
Pulmonary oedema 52.62 11.19 277 152933 100382 110335707
Tachyarrhythmia 52.53 11.19 61 153149 8200 110427889
Brain natriuretic peptide increased 52.46 11.19 71 153139 11138 110424951
Orthostatic hypotension 52.37 11.19 206 153004 66043 110370046
Injection site erythema 52.14 11.19 33 153177 94143 110341946
Angioedema 52.14 11.19 272 152938 98228 110337861
Pain in extremity 51.70 11.19 429 152781 486689 109949400
Epilepsy 51.63 11.19 38 153172 100171 110335918
Hypovolaemia 51.56 11.19 101 153109 21573 110414516
Myocardial ischaemia 51.37 11.19 114 153096 26570 110409519
Intentional product use issue 51.23 11.19 174 153036 247732 110188357
Hip arthroplasty 51.19 11.19 8 153202 55805 110380284
N-terminal prohormone brain natriuretic peptide increased 50.79 11.19 52 153158 6069 110430020
Cognitive disorder 50.78 11.19 248 152962 87263 110348826
Cardio-respiratory arrest 50.76 11.19 304 152906 115532 110320557
Taste disorder 50.47 11.19 14 153196 65373 110370716
Faeces discoloured 50.25 11.19 131 153079 33817 110402272
Injection site bruising 50.21 11.19 6 153204 51257 110384832
Injection site pruritus 50.20 11.19 6 153204 51252 110384837
Dilatation ventricular 49.96 11.19 43 153167 4032 110432057
Dyspepsia 49.76 11.19 120 153090 190845 110245244
Feeling abnormal 48.79 11.19 422 152788 180289 110255800
Death 48.43 11.19 1289 151921 697580 109738509
Ventricular hypertrophy 48.14 11.19 54 153156 6991 110429098
Live birth 48.10 11.19 18 153192 69466 110366623
Anhedonia 46.97 11.19 80 153130 15348 110420741
Hypoxia 46.97 11.19 324 152886 129191 110306898
Foot deformity 46.68 11.19 6 153204 48474 110387615
Sleep disorder due to a general medical condition 46.61 11.19 8 153202 52104 110383985
Abdominal wall haematoma 46.50 11.19 48 153162 5657 110430432
Osteoporosis 46.27 11.19 32 153178 87120 110348969
Lactic acidosis 46.20 11.19 252 152958 92559 110343530
Conduction disorder 46.12 11.19 41 153169 4014 110432075
Bundle branch block right 45.99 11.19 70 153140 12221 110423868
Exostosis 45.96 11.19 5 153205 45951 110390138
Road traffic accident 45.40 11.19 49 153161 107349 110328740
Pulmonary arterial pressure increased 45.19 11.19 45 153165 5082 110431007
Liver function test increased 45.07 11.19 34 153176 88514 110347575
Rectal haemorrhage 44.18 11.19 301 152909 119532 110316557
Blood pressure decreased 44.18 11.19 292 152918 114799 110321290
Gastrooesophageal reflux disease 43.87 11.19 117 153093 179859 110256230
Chronic obstructive pulmonary disease 43.76 11.19 280 152930 108878 110327211
Malignant neoplasm progression 43.68 11.19 112 153098 174455 110261634
Fear 43.43 11.19 98 153112 23095 110412994
Angina unstable 43.32 11.19 80 153130 16352 110419737
Cardiorenal syndrome 42.97 11.19 29 153181 1889 110434200
Atrial thrombosis 41.77 11.19 40 153170 4306 110431783
Prothrombin time shortened 41.73 11.19 37 153173 3609 110432480
Adverse event 41.34 11.19 54 153156 108755 110327334
Activated partial thromboplastin time prolonged 41.31 11.19 94 153116 22274 110413815
Joint stiffness 40.89 11.19 21 153189 67222 110368867
Occult blood positive 40.83 11.19 51 153159 7394 110428695
Cytomegalovirus infection 39.58 11.19 13 153197 54431 110381658
Immunodeficiency 39.42 11.19 4 153206 38834 110397255
Alveolitis 39.19 11.19 39 153171 4400 110431689
Congestive hepatopathy 39.12 11.19 42 153168 5178 110430911
Ear infection 39.04 11.19 19 153191 62713 110373376
Electrocardiogram QRS complex prolonged 38.96 11.19 67 153143 12954 110423135
Blood lactic acid 38.83 11.19 17 153193 461 110435628
Disorientation 38.68 11.19 197 153013 70474 110365615
Oral herpes 38.55 11.19 3 153207 36077 110400012
Gait inability 38.53 11.19 82 153128 136294 110299795
Shock haemorrhagic 38.15 11.19 103 153107 27144 110408945
Haematocrit decreased 38.09 11.19 187 153023 65930 110370159
Injection site swelling 38.02 11.19 19 153191 61771 110374318
Contusion 37.37 11.19 181 153029 233180 110202909
Drug ineffective for unapproved indication 37.09 11.19 53 153157 102785 110333304
Hypocoagulable state 37.04 11.19 30 153180 2585 110433504
Vomiting 37.04 11.19 1578 151632 909097 109526992
Multiple sclerosis relapse 36.52 11.19 12 153198 50228 110385861
Neuralgia 36.27 11.19 11 153199 48467 110387622
Supraventricular extrasystoles 36.07 11.19 50 153160 8023 110428066
Pregnancy 35.74 11.19 13 153197 51054 110385035
Electrocardiogram QT shortened 35.57 11.19 14 153196 288 110435801
Jugular vein distension 35.17 11.19 24 153186 1592 110434497
Intentional self-injury 35.17 11.19 5 153205 37424 110398665
Feeling hot 34.83 11.19 45 153165 91061 110345028
Peripheral embolism 34.58 11.19 26 153184 2009 110434080
Pyrexia 34.55 11.19 964 152246 897301 109538788
Transfusion 34.38 11.19 95 153115 25377 110410712
Liver disorder 34.26 11.19 93 153117 142150 110293939
Circulatory collapse 34.23 11.19 134 153076 42859 110393230
Oliguria 34.01 11.19 78 153132 18579 110417510
Urine output decreased 33.94 11.19 81 153129 19795 110416294
Acute respiratory failure 33.92 11.19 199 153011 75061 110361028
Hypochromic anaemia 33.72 11.19 31 153179 3170 110432919
Pulmonary congestion 33.71 11.19 107 153103 30859 110405230
Oropharyngeal pain 33.68 11.19 87 153123 135189 110300900
Potentiating drug interaction 33.65 11.19 59 153151 11584 110424505
Electrocardiogram repolarisation abnormality 33.53 11.19 27 153183 2308 110433781
Sudden death 32.94 11.19 91 153119 24304 110411785
Laryngitis 32.88 11.19 9 153201 42402 110393687
Ventricular dysfunction 32.78 11.19 46 153164 7465 110428624
Coronary artery bypass 32.52 11.19 41 153169 6001 110430088
Therapy partial responder 32.47 11.19 6 153204 37055 110399034
Suicidal ideation 32.33 11.19 50 153160 93887 110342202
Medication error 32.15 11.19 253 152957 105113 110330976
Cardiac death 31.82 11.19 23 153187 1673 110434416
Calcium deficiency 31.69 11.19 20 153190 1162 110434927
Headache 31.65 11.19 956 152254 881421 109554668
Herpes zoster 31.60 11.19 64 153146 108315 110327774
Amnesia 31.56 11.19 252 152958 105156 110330933
Blood loss anaemia 31.37 11.19 74 153136 17951 110418138
Mitral valve stenosis 30.94 11.19 21 153189 1381 110434708
Blood pressure increased 30.92 11.19 220 152990 258153 110177936
Left atrial dilatation 30.92 11.19 31 153179 3529 110432560
Sopor 30.81 11.19 116 153094 36430 110399659
Cyanosis 30.77 11.19 101 153109 29640 110406449
Concomitant disease progression 30.56 11.19 31 153179 3579 110432510
Dialysis 30.37 11.19 77 153133 19542 110416547
Chromatopsia 29.97 11.19 16 153194 677 110435412
Haemoptysis 29.82 11.19 185 153025 71169 110364920
Lung disorder 29.79 11.19 138 153072 179909 110256180
Abdominal discomfort 29.73 11.19 376 152834 393482 110042607
Chronic kidney disease 29.54 11.19 194 153016 76097 110359992
Stupor 29.42 11.19 46 153164 8219 110427870
Colitis 29.34 11.19 61 153149 102262 110333827
Neck pain 29.28 11.19 81 153129 123049 110313040
Right atrial dilatation 29.22 11.19 18 153192 1002 110435087
Neoplasm progression 28.97 11.19 28 153182 64567 110371522
Haemodialysis 28.96 11.19 71 153139 17648 110418441
Decreased appetite 28.81 11.19 863 152347 474983 109961106
Pulse absent 28.55 11.19 54 153156 11238 110424851
Aortic valve incompetence 28.37 11.19 53 153157 10928 110425161
Liver function test abnormal 28.34 11.19 178 153032 68772 110367317
Drug therapeutic incompatibility 28.07 11.19 10 153200 154 110435935
Metabolic acidosis 28.00 11.19 235 152975 99509 110336580
Cardioversion 27.44 11.19 24 153186 2299 110433790
Anaphylactic reaction 27.32 11.19 75 153135 114225 110321864
Muscle spasticity 27.14 11.19 8 153202 35907 110400182
Mucosal inflammation 26.99 11.19 58 153152 96083 110340006
Respiratory distress 26.58 11.19 175 153035 68699 110367390
Influenza 26.58 11.19 132 153078 168969 110267120
Aortic stenosis 26.51 11.19 57 153153 13002 110423087
Coagulation time prolonged 26.44 11.19 26 153184 2891 110433198
Sinus arrest 26.43 11.19 31 153179 4211 110431878
Mental status changes 26.17 11.19 188 153022 75934 110360155
Catheter management 26.16 11.19 29 153181 3706 110432383
Adrenal insufficiency 26.13 11.19 13 153197 42377 110393712
Irritability 26.12 11.19 17 153193 47792 110388297
Exercise tolerance decreased 26.04 11.19 54 153156 12013 110424076
Wrong product administered 25.98 11.19 51 153159 10909 110425180
Lupus-like syndrome 25.93 11.19 12 153198 40780 110395309
Diabetic ketoacidosis 25.77 11.19 13 153197 42045 110394044
Head injury 25.74 11.19 123 153087 42894 110393195
Benign gastrointestinal neoplasm 25.73 11.19 9 153201 131 110435958
International normalised ratio fluctuation 25.73 11.19 30 153180 4050 110432039
Back injury 25.70 11.19 17 153193 47382 110388707
Pericarditis 25.53 11.19 188 153022 218926 110217163
Lymphocyte count decreased 25.45 11.19 25 153185 57218 110378871
Procalcitonin abnormal 25.20 11.19 12 153198 397 110435692
Aspergillus infection 25.08 11.19 3 153207 25613 110410476
Procedural pain 24.98 11.19 9 153201 35556 110400533
Hypophagia 24.92 11.19 141 153069 52485 110383604
Labelled drug-drug interaction medication error 24.70 11.19 93 153117 29209 110406880
Blood pressure fluctuation 24.64 11.19 41 153169 74783 110361306
Cytokine release syndrome 24.60 11.19 37 153173 70269 110365820
Hepatic cytolysis 24.53 11.19 24 153186 55029 110381060
Drug dependence 24.45 11.19 20 153190 50000 110386089
Acne 24.37 11.19 8 153202 33512 110402577
Constipation 24.30 11.19 349 152861 357437 110078652
Disability 24.22 11.19 6 153204 30217 110405872
Pulseless electrical activity 24.12 11.19 64 153146 16693 110419396
Dry eye 24.09 11.19 25 153185 55768 110380321
Fungal infection 24.00 11.19 21 153189 50785 110385304
Electrocardiogram ST-T change 23.93 11.19 19 153191 1591 110434498
Gastric ulcer 23.91 11.19 114 153096 39713 110396376
Finger deformity 23.88 11.19 8 153202 33084 110403005
Lymphopenia 23.75 11.19 13 153197 40157 110395932
Transplant rejection 23.75 11.19 3 153207 24564 110411525
Cor pulmonale 23.74 11.19 22 153188 2272 110433817
Cardiac output decreased 23.69 11.19 21 153189 2048 110434041
Skin exfoliation 23.69 11.19 54 153156 87597 110348492
Pulmonary fibrosis 23.62 11.19 68 153142 101974 110334115
Joint dislocation 23.43 11.19 9 153201 34181 110401908
Exposure during pregnancy 23.37 11.19 136 153074 167288 110268801
Myasthenic syndrome 23.25 11.19 17 153193 1259 110434830
Prescribed underdose 23.10 11.19 34 153176 65140 110370949
Right ventricular dilatation 23.00 11.19 22 153188 2365 110433724
Polymerase chain reaction 22.96 11.19 8 153202 115 110435974
No adverse event 22.92 11.19 42 153168 73797 110362292
Blood culture positive 22.79 11.19 43 153167 8933 110427156
Drug reaction with eosinophilia and systemic symptoms 22.66 11.19 50 153160 82045 110354044
Drug monitoring procedure not performed 22.62 11.19 17 153193 1313 110434776
Hyperhidrosis 22.62 11.19 375 152835 186923 110249166
Atrioventricular dissociation 22.58 11.19 11 153199 383 110435706
Eczema 22.55 11.19 41 153169 72252 110363837
Hypersensitivity vasculitis 22.49 11.19 37 153173 6900 110429189
Erythrodermic psoriasis 22.22 11.19 20 153190 1990 110434099
Heparin-induced thrombocytopenia 22.21 11.19 49 153161 11375 110424714
Peripheral ischaemia 22.14 11.19 48 153162 11010 110425079
Haemophagocytic lymphohistiocytosis 22.14 11.19 8 153202 31551 110404538
Haemothorax 22.12 11.19 37 153173 6994 110429095
Rhinitis 21.21 11.19 3 153207 22542 110413547
Coronary arterial stent insertion 21.17 11.19 33 153177 5882 110430207
Haemarthrosis 21 11.19 37 153173 7292 110428797
Blood alkaline phosphatase increased 20.91 11.19 169 153041 70766 110365323
Renal oncocytoma 20.73 11.19 9 153201 239 110435850
Central nervous system injury 20.67 11.19 8 153202 157 110435932
Cerebral haematoma 20.66 11.19 43 153167 9589 110426500
Dermatitis atopic 20.60 11.19 5 153205 25536 110410553
Palmar-plantar erythrodysaesthesia syndrome 20.56 11.19 16 153194 41009 110395080
Appendicitis 20.34 11.19 7 153203 28457 110407632
Schizophrenia 20.31 11.19 3 153207 21823 110414266
Dyspnoea paroxysmal nocturnal 20.30 11.19 21 153189 2481 110433608
Accidental overdose 20.18 11.19 132 153078 51702 110384387
Uveitis 20.16 11.19 3 153207 21707 110414382
Fluid replacement 20.12 11.19 14 153196 959 110435130
Thyrotoxic crisis 20.03 11.19 19 153191 2021 110434068
Prothrombin level decreased 19.99 11.19 18 153192 1792 110434297
Haemorrhagic disorder 19.96 11.19 18 153192 1795 110434294
Ecchymosis 19.88 11.19 61 153149 17277 110418812
Splenic injury 19.78 11.19 9 153201 268 110435821
Therapy non-responder 19.77 11.19 132 153078 157175 110278914
Impaired work ability 19.75 11.19 6 153204 26413 110409676
Pain in jaw 19.73 11.19 130 153080 51047 110385042
Anticoagulation drug level above therapeutic 19.68 11.19 28 153182 4602 110431487
Lung transplant 19.63 11.19 30 153180 5256 110430833
Ear pain 19.62 11.19 27 153183 53199 110382890
Injection site mass 19.50 11.19 5 153205 24608 110411481
Oxygen consumption increased 19.35 11.19 31 153179 5654 110430435
Chills 19.21 11.19 170 153040 190410 110245679
Multiple organ dysfunction syndrome 19.15 11.19 306 152904 151404 110284685
Hypertransaminasaemia 19.08 11.19 5 153205 24250 110411839
Retroperitoneal haematoma 18.94 11.19 32 153178 6099 110429990
Heart sounds abnormal 18.91 11.19 16 153194 1466 110434623
Encephalomalacia 18.72 11.19 16 153194 1486 110434603
Puncture site haemorrhage 18.67 11.19 12 153198 720 110435369
Dyschromatopsia 18.66 11.19 15 153195 1279 110434810
Subdural haemorrhage 18.65 11.19 33 153177 6525 110429564
Catheter placement 18.62 11.19 23 153187 3297 110432792
Rhinorrhoea 18.62 11.19 76 153134 102590 110333499
Drug resistance 18.46 11.19 31 153179 56343 110379746
Intracardiac thrombus 18.42 11.19 26 153184 4242 110431847
Lymphadenopathy 18.35 11.19 38 153172 63797 110372292
Blood bilirubin increased 18.24 11.19 173 153037 75799 110360290
Tricuspid valve sclerosis 18.23 11.19 5 153205 30 110436059
Chronic sinusitis 18.22 11.19 6 153204 25078 110411011
Walking aid user 18.21 11.19 6 153204 25069 110411020
Sudden cardiac death 18.19 11.19 30 153180 5607 110430482
Rash pruritic 18.16 11.19 72 153138 97997 110338092
Ischaemic hepatitis 18.14 11.19 27 153183 4621 110431468
Kussmaul respiration 18.09 11.19 10 153200 454 110435635
Progressive multifocal leukoencephalopathy 18.07 11.19 6 153204 24950 110411139
Atrial enlargement 18.01 11.19 14 153196 1137 110434952
Transplant evaluation 17.85 11.19 17 153193 1818 110434271
Vision blurred 17.73 11.19 264 152946 128758 110307331
Cataract 17.65 11.19 54 153156 79431 110356658
Pneumocystis jirovecii pneumonia 17.50 11.19 20 153190 42715 110393374
Duodenal ulcer haemorrhage 17.38 11.19 36 153174 8001 110428088
Dystonia 17.34 11.19 7 153203 25798 110410291
Emotional distress 17.33 11.19 114 153096 44733 110391356
Completed suicide 17.31 11.19 234 152976 242147 110193942
Posterior reversible encephalopathy syndrome 17.23 11.19 13 153197 33848 110402241
Sedation 17.20 11.19 45 153165 69638 110366451
Blood sodium decreased 17.06 11.19 101 153109 38218 110397871
Neurotoxicity 17.02 11.19 20 153190 42187 110393902
Subcutaneous haematoma 16.98 11.19 21 153189 3015 110433074
Cystitis 16.80 11.19 42 153168 65994 110370095
Catheter site erythema 16.72 11.19 30 153180 5998 110430091
Cutaneous vasculitis 16.71 11.19 47 153163 12682 110423407
Dry skin 16.68 11.19 225 152985 107428 110328661
General physical health deterioration 16.66 11.19 455 152755 424840 110011249
Cardiopulmonary failure 16.63 11.19 35 153175 7868 110428221
Iron deficiency anaemia 16.59 11.19 87 153123 31472 110404617
Cerebral atrophy 16.58 11.19 38 153172 9047 110427042
Nausea 16.56 11.19 1954 151256 1233736 109202353
Hypochromasia 16.51 11.19 11 153199 701 110435388
Underdose 16.50 11.19 40 153170 63514 110372575
Mitral valve disease 16.49 11.19 22 153188 3403 110432686
Rales 16.47 11.19 73 153137 24666 110411423
Oxygen saturation decreased 16.34 11.19 307 152903 156675 110279414
Systolic dysfunction 16.32 11.19 25 153185 4390 110431699
Ventricular hypokinesia 16.31 11.19 43 153167 11171 110424918
Haemorrhagic stroke 16.26 11.19 49 153161 13740 110422349
Bundle branch block 16.21 11.19 16 153194 1787 110434302
Infective exacerbation of chronic obstructive airways disease 16.15 11.19 21 153189 3169 110432920
Pyroglutamic acidosis 16.14 11.19 17 153193 2051 110434038
Limited symptom panic attack 16.09 11.19 5 153205 49 110436040
Azotaemia 16.05 11.19 40 153170 10045 110426044
Walking distance test abnormal 16.05 11.19 11 153199 735 110435354
Hypoglycaemic coma 15.94 11.19 28 153182 5505 110430584
Hepatic steatosis 15.86 11.19 27 153183 48804 110387285
Skin fissures 15.85 11.19 7 153203 24451 110411638
Pulse pressure decreased 15.84 11.19 9 153201 431 110435658
Vascular graft 15.75 11.19 17 153193 2108 110433981
Cor pulmonale chronic 15.67 11.19 9 153201 440 110435649
Basal ganglia haemorrhage 15.59 11.19 16 153194 1872 110434217
Rhythm idioventricular 15.54 11.19 11 153199 774 110435315
Bundle branch block bilateral 15.54 11.19 6 153204 117 110435972
Vaginal discharge 15.47 11.19 3 153207 17905 110418184
Refusal of treatment by patient 15.47 11.19 38 153172 9456 110426633
Right-to-left cardiac shunt 15.47 11.19 8 153202 317 110435772
Enzyme induction 15.45 11.19 6 153204 119 110435970
Left ventricular dilatation 15.43 11.19 14 153196 1408 110434681
Drug level above therapeutic 15.42 11.19 43 153167 11545 110424544
Haematotoxicity 15.38 11.19 5 153205 21077 110415012
Therapeutic response increased 15.38 11.19 10 153200 612 110435477
Cytomegalovirus viraemia 15.30 11.19 3 153207 17761 110418328
Erythema 15.29 11.19 298 152912 291149 110144940
Tremor 15.26 11.19 193 153017 202039 110234050
Respiratory acidosis 15.25 11.19 48 153162 13778 110422311
Infusion site reaction 15.20 11.19 3 153207 17679 110418410
Lung infiltration 15.15 11.19 71 153139 24557 110411532
Superinfection 15.12 11.19 28 153182 5735 110430354
Gastric ulcer haemorrhage 14.99 11.19 39 153171 10055 110426034
Injury 14.99 11.19 165 153045 177100 110258989
Intervertebral disc protrusion 14.93 11.19 10 153200 27688 110408401
Blood potassium decreased 14.92 11.19 127 153083 53987 110382102
Catheterisation cardiac 14.91 11.19 29 153181 6162 110429927
Diverticulum intestinal haemorrhagic 14.90 11.19 25 153185 4738 110431351
Tachycardia induced cardiomyopathy 14.89 11.19 7 153203 225 110435864
Coma scale abnormal 14.88 11.19 38 153172 9688 110426401
Nephrogenic systemic fibrosis 14.84 11.19 27 153183 5456 110430633
Haemodynamic instability 14.84 11.19 67 153143 22821 110413268
PO2 decreased 14.82 11.19 20 153190 3128 110432961
Microcytic anaemia 14.82 11.19 29 153181 6189 110429900
Product dose omission in error 14.81 11.19 7 153203 23505 110412584
Hypokalaemia 14.81 11.19 344 152866 182104 110253985
Conjunctivitis 14.75 11.19 15 153195 33777 110402312
Injection site urticaria 14.63 11.19 3 153207 17212 110418877
Right ventricular systolic pressure increased 14.59 11.19 12 153198 1057 110435032
Graft versus host disease 14.56 11.19 4 153206 18802 110417287
Cardiac pacemaker insertion 14.55 11.19 29 153181 6272 110429817
Gastritis erosive 14.49 11.19 43 153167 11957 110424132
Acute pulmonary oedema 14.37 11.19 54 153156 16942 110419147
Device issue 14.32 11.19 16 153194 34519 110401570
Burning feet syndrome 14.26 11.19 7 153203 248 110435841
Brain stem haemorrhage 14.23 11.19 15 153195 1811 110434278
Multiple sclerosis 14.23 11.19 9 153201 25689 110410400
Cerebellar haemorrhage 14.23 11.19 20 153190 3251 110432838
Aortic valve calcification 14.22 11.19 11 153199 887 110435202
Upper respiratory tract infection 14.20 11.19 115 153095 131213 110304876
Hypophosphataemia 14.17 11.19 15 153195 33167 110402922
Catheter site infection 14.09 11.19 33 153177 7967 110428122
Peripheral artery stenosis 14.04 11.19 13 153197 1341 110434748
Dermatitis exfoliative 14.03 11.19 41 153169 11306 110424783
Right ventricular dysfunction 13.98 11.19 20 153190 3303 110432786
Device related sepsis 13.97 11.19 32 153178 7615 110428474
Acute hepatic failure 13.95 11.19 18 153192 36450 110399639
Blood pressure immeasurable 13.94 11.19 17 153193 2406 110433683
Toxic nodular goitre 13.92 11.19 5 153205 79 110436010
Thrombotic microangiopathy 13.82 11.19 12 153198 29137 110406952
Arrhythmia supraventricular 13.81 11.19 17 153193 2429 110433660
Puncture site haematoma 13.78 11.19 7 153203 267 110435822
Aphthous ulcer 13.77 11.19 6 153204 21130 110414959
Unresponsive to stimuli 13.73 11.19 142 153068 63648 110372441
Prohormone brain natriuretic peptide increased 13.71 11.19 8 153202 403 110435686
Hemiparesis 13.71 11.19 106 153104 43797 110392292
Colon cancer 13.70 11.19 52 153158 16391 110419698
Skin disorder 13.69 11.19 24 153186 42889 110393200
Paracentesis 13.67 11.19 13 153197 1387 110434702
Obstructive airways disorder 13.66 11.19 27 153183 46122 110389967
Gastrointestinal ulcer haemorrhage 13.66 11.19 14 153196 1636 110434453
Panic attack 13.62 11.19 12 153198 28928 110407161
Morning glory syndrome 13.46 11.19 3 153207 6 110436083
Osteonecrosis of jaw 13.45 11.19 29 153181 47988 110388101
Mesenteric artery embolism 13.42 11.19 5 153205 88 110436001
Arteriovenous malformation 13.41 11.19 15 153195 1936 110434153
Colour blindness 13.41 11.19 9 153201 581 110435508
Hepatomegaly 13.37 11.19 62 153148 21352 110414737
Shock 13.35 11.19 123 153087 53465 110382624
Bronchopulmonary aspergillosis 13.33 11.19 13 153197 29850 110406239
Duodenal ulcer 13.31 11.19 58 153152 19456 110416633
PCO2 decreased 13.26 11.19 19 153191 3142 110432947
Injection site rash 13.25 11.19 8 153202 23411 110412678
Protein total 13.17 11.19 4 153206 36 110436053
Acidosis 13.17 11.19 64 153146 22467 110413622
Hyponatraemic syndrome 13.14 11.19 10 153200 787 110435302
Leukocytosis 13.13 11.19 123 153087 53705 110382384
Drug eruption 12.98 11.19 35 153175 53624 110382465
Oesophageal achalasia 12.98 11.19 11 153199 1010 110435079
Sensory disturbance 12.96 11.19 4 153206 17425 110418664
Chorea 12.93 11.19 19 153191 3216 110432873
Retroperitoneal haemorrhage 12.92 11.19 27 153183 6038 110430051
Product storage error 12.89 11.19 7 153203 21721 110414368
Electrocardiogram T wave amplitude decreased 12.88 11.19 10 153200 811 110435278
Metastases to lung 12.88 11.19 8 153202 23055 110413034
Choroidal haemorrhage 12.76 11.19 6 153204 193 110435896
Blood creatine increased 12.71 11.19 40 153170 11481 110424608
Burning sensation 12.70 11.19 51 153159 69161 110366928
Infected skin ulcer 12.65 11.19 21 153189 3946 110432143
Abnormal loss of weight 12.62 11.19 37 153173 10220 110425869
Affect lability 12.61 11.19 5 153205 18632 110417457
Nodule 12.59 11.19 16 153194 32615 110403474
Spinal pain 12.48 11.19 5 153205 18510 110417579
Blood electrolytes abnormal 12.47 11.19 15 153195 2093 110433996
Suicide attempt 12.38 11.19 88 153122 103306 110332783
Neutrophil count increased 12.35 11.19 18 153192 34634 110401455
Blood lactic acid increased 12.34 11.19 49 153161 15772 110420317
Intraventricular haemorrhage 12.30 11.19 25 153185 5482 110430607
Pulmonary embolism 12.27 11.19 216 152994 214258 110221831
Body temperature increased 12.27 11.19 37 153173 54676 110381413
Cardiac tamponade 12.24 11.19 39 153171 11268 110424821
Concomitant disease aggravated 12.22 11.19 50 153160 16314 110419775
Balloon atrial septostomy 12.15 11.19 5 153205 116 110435973
Heart transplant 12.03 11.19 13 153197 1615 110434474
Bronchiectasis 12.01 11.19 20 153190 36473 110399616
Dizziness postural 12.01 11.19 46 153164 14563 110421526
Drug tolerance 11.99 11.19 4 153206 16581 110419508
Second primary malignancy 11.98 11.19 5 153205 18063 110418026
Large intestinal haemorrhage 11.92 11.19 18 153192 3121 110432968
Electrocardiogram change 11.87 11.19 12 153198 1379 110434710
Cardiac valve disease 11.87 11.19 27 153183 6394 110429695
Urethral haemorrhage 11.83 11.19 8 153202 523 110435566
Dementia Alzheimer's type 11.79 11.19 10 153200 919 110435170
Abdominal tenderness 11.74 11.19 41 153169 12416 110423673
Muscle haemorrhage 11.74 11.19 28 153182 6841 110429248
Electrocardiogram T wave abnormal 11.71 11.19 21 153189 4196 110431893
Therapy interrupted 11.68 11.19 33 153177 49789 110386300
Cheyne-Stokes respiration 11.63 11.19 8 153202 538 110435551
Mitral valve sclerosis 11.62 11.19 7 153203 374 110435715
Rash maculo-papular 11.62 11.19 58 153152 74164 110361925
Ocular hyperaemia 11.62 11.19 23 153187 39263 110396826
Adverse drug reaction 11.53 11.19 208 153002 105351 110330738
Prothrombin level increased 11.51 11.19 8 153202 547 110435542
Drug withdrawal syndrome 11.50 11.19 22 153188 38032 110398057
Cardiovascular disorder 11.46 11.19 62 153148 22698 110413391
Drug dose omission by device 11.40 11.19 3 153207 14513 110421576
Hypoglycaemic seizure 11.40 11.19 10 153200 962 110435127
Electrocardiogram R on T phenomenon 11.40 11.19 3 153207 15 110436074
Catheter site pruritus 11.39 11.19 15 153195 2291 110433798
Haematoma evacuation 11.37 11.19 7 153203 389 110435700
Creatinine renal clearance decreased 11.37 11.19 60 153150 21755 110414334
Anticoagulation drug level below therapeutic 11.35 11.19 13 153197 1721 110434368
Aspiration pleural cavity 11.34 11.19 13 153197 1724 110434365
Blood chloride decreased 11.33 11.19 33 153177 9082 110427007
Acquired haemophilia 11.31 11.19 16 153194 2615 110433474
Myasthenia gravis 11.28 11.19 8 153202 21503 110414586
Traumatic intracranial haemorrhage 11.28 11.19 12 153198 1464 110434625
Incorrect route of product administration 11.25 11.19 48 153162 64013 110372076
Sensory loss 11.23 11.19 8 153202 21449 110414640

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
ATC C01AA05 CARDIOVASCULAR SYSTEM
CARDIAC THERAPY
CARDIAC GLYCOSIDES
Digitalis glycosides
FDA CS M0003451 Cardiac Glycosides
FDA EPC N0000175568 Cardiac Glycoside
MeSH PA D000889 Anti-Arrhythmia Agents
MeSH PA D002316 Cardiotonic Agents
MeSH PA D002317 Cardiovascular Agents
MeSH PA D004791 Enzyme Inhibitors
MeSH PA D020011 Protective Agents
CHEBI has role CHEBI:22587 antiviral agent
CHEBI has role CHEBI:35441 antiinfective agent
CHEBI has role CHEBI:35469 antidepressant
CHEBI has role CHEBI:35480 analgesic
CHEBI has role CHEBI:35526 hypoglycemic agent
CHEBI has role CHEBI:35554 cardiovascular drug
CHEBI has role CHEBI:35610 antineoplastic agent
CHEBI has role CHEBI:35623 anticonvulsant
CHEBI has role CHEBI:35674 antihypertensive agent
CHEBI has role CHEBI:35842 antirheumatic drug
CHEBI has role CHEBI:38070 anti-arrhythmia drug
CHEBI has role CHEBI:38147 cardiotonic drug
CHEBI has role CHEBI:50919 antiemetic
CHEBI has role CHEBI:53000 epitope
CHEBI has role CHEBI:63510 EC 3.6.3.9 (<em>Na</em><small><sup>+</small></sup>/<em>K</em><small><sup>+</small></sup>-transporting ATPase) inhibitor
CHEBI has role CHEBI:64946 anti-HIV agent
CHEBI has role CHEBI:64951 anti-HBV agent
CHEBI has role CHEBI:67079 anti-inflammatory agent
CHEBI has role CHEBI:74518 anti-obesity agent

Related Drugs by ATC class:

C01AA Digitalis glycosides 7 drugs
acetyldigitoxinacetyldigoxindeslanosidedigitoxingitoformatelanatoside Cmetildigoxin

Drug Use | Suggest Off label Use Form| |View source of the data|

DiseaseRelationSNOMED_IDDOID
Poisoning by digitalis glycoside indication 12876009
Chronic heart failure indication 48447003
Atrial fibrillation indication 49436004 DOID:0060224
Senile cardiac amyloidosis contraindication 16573007
Myocardial infarction contraindication 22298006 DOID:5844
Sick sinus syndrome contraindication 36083008 DOID:13884
Myxedema contraindication 43153006 DOID:11634
Hypokalemia contraindication 43339004
Sinus bradycardia contraindication 49710005
Myocarditis contraindication 50920009 DOID:820
Acute nephropathy contraindication 58574008
Hypercalcemia contraindication 66931009 DOID:12678
Ventricular fibrillation contraindication 71908006
Wolff-Parkinson-White pattern contraindication 74390002 DOID:384
Cor pulmonale contraindication 83291003 DOID:8515
Constrictive pericarditis contraindication 85598007 DOID:11481
Kidney disease contraindication 90708001 DOID:557
Hypomagnesemia contraindication 190855004
Atrioventricular block contraindication 233917008 DOID:0050820
Idiopathic hypertrophic subaortic stenosis contraindication 360465008
Restrictive cardiomyopathy contraindication 415295002 DOID:397




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

None

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])		Mechanism
action		Bioact sourceMoA source
Sodium/potassium-transporting ATPase Transporter INHIBITOR IC50 6.40 CHEMBL CHEMBL
Potassium voltage-gated channel subfamily H member 2 Ion channel IC50 4.14 WOMBAT-PK
Nuclear receptor ROR-gamma Nuclear hormone receptor IC50 5.70 CHEMBL
Signal transducer and activator of transcription 3 Transcription factor IC50 5.73 CHEMBL
Sodium/potassium-transporting ATPase subunit alpha-2 Ion channel IC50 5.78 DRUG MATRIX
Nuclear receptor ROR-gamma Nuclear hormone receptor IC50 5.70 CHEMBL
Sodium/potassium-transporting ATPase subunit alpha-1 Transporter IC50 6.30 CHEMBL

External reference:

IDSource
4018047 VUID
N0000146388 NUI
D00298 KEGG_DRUG
3407 RXNORM
4018047 VANDF
C0012265 UMLSCUI
CHEBI:4551 CHEBI
DGX PDB_CHEM_ID
CHEMBL1751 ChEMBL_ID
D004077 MESH_DESCRIPTOR_UI
DB00390 DRUGBANK_ID
4726 IUPHAR_LIGAND_ID
389 INN_ID
73K4184T59 UNII
2724385 PUBCHEM_CID
1413 MMSL
4597 MMSL
d00210 MMSL
000593 NDDF
387461009 SNOMEDCT_US
796001 SNOMEDCT_US
73K4184T59 INXIGHT DRUGS

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
Digoxin HUMAN PRESCRIPTION DRUG LABEL 1 0054-0057 SOLUTION 0.05 mg ORAL NDA 26 sections
Digoxin HUMAN PRESCRIPTION DRUG LABEL 1 0115-9811 TABLET 125 ug ORAL ANDA 26 sections
Digoxin HUMAN PRESCRIPTION DRUG LABEL 1 0115-9822 TABLET 250 ug ORAL ANDA 26 sections
Digoxin HUMAN PRESCRIPTION DRUG LABEL 1 0143-1240 TABLET 125 ug ORAL ANDA 26 sections
Digoxin HUMAN PRESCRIPTION DRUG LABEL 1 0143-1241 TABLET 250 ug ORAL ANDA 26 sections
Digoxin HUMAN PRESCRIPTION DRUG LABEL 1 0404-9850 INJECTION 0.25 mg INTRAVENOUS ANDA 16 sections
Digoxin HUMAN PRESCRIPTION DRUG LABEL 1 0404-9850 INJECTION 0.25 mg INTRAVENOUS ANDA 16 sections
Digoxin HUMAN PRESCRIPTION DRUG LABEL 1 0615-8202 TABLET 125 ug ORAL ANDA 26 sections
Digoxin HUMAN PRESCRIPTION DRUG LABEL 1 0641-1410 INJECTION 0.25 mg INTRAMUSCULAR ANDA 25 sections
Digoxin HUMAN PRESCRIPTION DRUG LABEL 1 0641-6184 INJECTION 0.25 mg INTRAMUSCULAR ANDA 25 sections
Digoxin HUMAN PRESCRIPTION DRUG LABEL 1 0781-3059 INJECTION, SOLUTION 250 ug INTRAMUSCULAR ANDA 26 sections
Digoxin HUMAN PRESCRIPTION DRUG LABEL 1 0904-5921 TABLET 125 ug ORAL ANDA 26 sections
Digoxin HUMAN PRESCRIPTION DRUG LABEL 1 0904-5922 TABLET 250 ug ORAL ANDA 26 sections
Digoxin HUMAN PRESCRIPTION DRUG LABEL 1 10135-747 TABLET 0.13 mg ORAL ANDA 27 sections
Digoxin HUMAN PRESCRIPTION DRUG LABEL 1 10135-747 TABLET 0.13 mg ORAL ANDA 27 sections
Digoxin HUMAN PRESCRIPTION DRUG LABEL 1 10135-748 TABLET 0.25 mg ORAL ANDA 27 sections
Digoxin HUMAN PRESCRIPTION DRUG LABEL 1 10135-748 TABLET 0.25 mg ORAL ANDA 27 sections
Digoxin HUMAN PRESCRIPTION DRUG LABEL 1 16714-590 TABLET 125 ug ORAL ANDA 25 sections
Digoxin HUMAN PRESCRIPTION DRUG LABEL 1 16714-591 TABLET 250 ug ORAL ANDA 25 sections
Digoxin HUMAN PRESCRIPTION DRUG LABEL 1 17856-0057 SOLUTION 0.05 mg ORAL NDA 25 sections
Digoxin HUMAN PRESCRIPTION DRUG LABEL 1 21695-678 TABLET 0.13 mg ORAL ANDA 17 sections
Digoxin HUMAN PRESCRIPTION DRUG LABEL 1 50090-0432 TABLET 125 ug ORAL ANDA 22 sections
Digox HUMAN PRESCRIPTION DRUG LABEL 1 50090-0962 TABLET 250 ug ORAL ANDA 23 sections
Digoxin HUMAN PRESCRIPTION DRUG LABEL 1 50090-4432 TABLET 125 ug ORAL ANDA 28 sections
Digoxin HUMAN PRESCRIPTION DRUG LABEL 1 50090-5276 TABLET 125 ug ORAL ANDA 22 sections
Digoxin HUMAN PRESCRIPTION DRUG LABEL 1 50090-5311 TABLET 250 ug ORAL ANDA 22 sections
Digoxin HUMAN PRESCRIPTION DRUG LABEL 1 50090-5642 TABLET 125 ug ORAL ANDA 25 sections
Digoxin HUMAN PRESCRIPTION DRUG LABEL 1 50090-5862 TABLET 250 ug ORAL ANDA 25 sections
Digoxin HUMAN PRESCRIPTION DRUG LABEL 1 50090-6588 TABLET 250 ug ORAL ANDA 25 sections
Digoxin Human Prescription Drug Label 1 50090-6708 TABLET 0.13 mg ORAL ANDA 25 sections