Stem definition | Drug id | CAS RN |
---|---|---|
882 | 20830-75-5 |
Dose | Unit | Route |
---|---|---|
0.25 | mg | O |
0.25 | mg | P |
Property | Value | Reference |
---|---|---|
BDDCS (Biopharmaceutical Drug Disposition Classification System) | 3 | Benet LZ, Broccatelli F, Oprea TI |
S (Water solubility) | 0.99 mg/mL | Benet LZ, Broccatelli F, Oprea TI |
EoM (Fraction excreted unchanged in urine) | 60 % | Benet LZ, Broccatelli F, Oprea TI |
MRTD (Maximum Recommended Therapeutic Daily Dose) | 0.00 µM/kg/day | Contrera JF, Matthews EJ, Kruhlak NL, Benz RD |
BA (Bioavailability) | 70 % | Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H |
Vd (Volume of distribution) | 4.10 L/kg | Lombardo F, Berellini G, Obach RS |
CL (Clearance) | 1.70 mL/min/kg | Lombardo F, Berellini G, Obach RS |
fu (Fraction unbound in plasma) | 0.70 % | Lombardo F, Berellini G, Obach RS |
t_half (Half-life) | 38 hours | Lombardo F, Berellini G, Obach RS |
Date | Agency | Company | Orphan |
---|---|---|---|
Oct. 24, 1975 | FDA | EUROHLTH INTL SARL |
MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
---|---|---|---|---|---|---|
Cardioactive drug level increased | 1174.10 | 10.42 | 329 | 78019 | 1730 | 46605984 |
Bradycardia | 900.43 | 10.42 | 804 | 77544 | 65494 | 46542220 |
International normalised ratio increased | 794.85 | 10.42 | 646 | 77702 | 46237 | 46561477 |
Atrial fibrillation | 729.10 | 10.42 | 883 | 77465 | 102707 | 46505007 |
Cardiac failure congestive | 559.05 | 10.42 | 728 | 77620 | 91022 | 46516692 |
Toxicity to various agents | 470.26 | 10.42 | 1072 | 77276 | 210694 | 46397020 |
Drug interaction | 458.58 | 10.42 | 1035 | 77313 | 202059 | 46405655 |
Cardiac failure | 384.12 | 10.42 | 566 | 77782 | 79382 | 46528332 |
Drug ineffective | 307.45 | 10.42 | 415 | 77933 | 677423 | 45930291 |
Hyperkalaemia | 265.32 | 10.42 | 374 | 77974 | 50335 | 46557379 |
Rheumatoid arthritis | 239.35 | 10.42 | 55 | 78293 | 240160 | 46367554 |
Acute kidney injury | 231.81 | 10.42 | 894 | 77454 | 234961 | 46372753 |
Pulmonary hypertension | 194.98 | 10.42 | 270 | 78078 | 35723 | 46571991 |
Bradyarrhythmia | 183.22 | 10.42 | 82 | 78266 | 1924 | 46605790 |
Right ventricular failure | 177.30 | 10.42 | 174 | 78174 | 15919 | 46591795 |
Product complaint | 162.41 | 10.42 | 146 | 78202 | 11955 | 46595759 |
Torsade de pointes | 157.93 | 10.42 | 144 | 78204 | 12010 | 46595704 |
Off label use | 156.30 | 10.42 | 248 | 78100 | 379593 | 46228121 |
Renal failure | 153.49 | 10.42 | 479 | 77869 | 113115 | 46494599 |
Drug hypersensitivity | 152.64 | 10.42 | 112 | 78236 | 243713 | 46364001 |
Dyspnoea | 146.74 | 10.42 | 1412 | 76936 | 514136 | 46093578 |
Melaena | 143.95 | 10.42 | 204 | 78144 | 27568 | 46580146 |
Arthralgia | 140.76 | 10.42 | 248 | 78100 | 364355 | 46243359 |
Pain | 134.75 | 10.42 | 385 | 77963 | 476563 | 46131151 |
Ventricular tachycardia | 134.52 | 10.42 | 154 | 78194 | 16813 | 46590901 |
Pulmonary arterial hypertension | 130.77 | 10.42 | 188 | 78160 | 25740 | 46581974 |
Gastrointestinal haemorrhage | 127.21 | 10.42 | 350 | 77998 | 77023 | 46530691 |
Cardioactive drug level above therapeutic | 114.28 | 10.42 | 30 | 78318 | 117 | 46607597 |
Atrioventricular block | 111.34 | 10.42 | 92 | 78256 | 6719 | 46600995 |
Rash | 107.11 | 10.42 | 279 | 78069 | 356233 | 46251481 |
Hypotension | 105.76 | 10.42 | 710 | 77638 | 231879 | 46375835 |
Arrhythmia | 100.89 | 10.42 | 197 | 78151 | 34644 | 46573070 |
Treatment failure | 97.31 | 10.42 | 19 | 78329 | 93068 | 46514646 |
Completed suicide | 95.21 | 10.42 | 64 | 78284 | 145856 | 46461858 |
Upper gastrointestinal haemorrhage | 94.28 | 10.42 | 128 | 78220 | 16610 | 46591104 |
Subdural haematoma | 93.10 | 10.42 | 112 | 78236 | 12885 | 46594829 |
Joint swelling | 90.65 | 10.42 | 87 | 78261 | 165986 | 46441728 |
Atrioventricular block first degree | 87.70 | 10.42 | 77 | 78271 | 6109 | 46601605 |
Injection site pain | 86.05 | 10.42 | 36 | 78312 | 107116 | 46500598 |
Nodal rhythm | 84.13 | 10.42 | 46 | 78302 | 1679 | 46606035 |
Atrioventricular block complete | 83.13 | 10.42 | 82 | 78266 | 7545 | 46600169 |
Syncope | 82.79 | 10.42 | 372 | 77976 | 104431 | 46503283 |
Synovitis | 79.53 | 10.42 | 6 | 78342 | 61069 | 46546645 |
Drug intolerance | 79.12 | 10.42 | 78 | 78270 | 146971 | 46460743 |
Fluid overload | 79.05 | 10.42 | 154 | 78194 | 27031 | 46580683 |
Injection site erythema | 78.19 | 10.42 | 15 | 78333 | 74412 | 46533302 |
International normalised ratio abnormal | 75.88 | 10.42 | 53 | 78295 | 3006 | 46604708 |
Alopecia | 75.54 | 10.42 | 97 | 78251 | 162317 | 46445397 |
Drug abuse | 75.24 | 10.42 | 9 | 78339 | 63399 | 46544315 |
Lower gastrointestinal haemorrhage | 74.81 | 10.42 | 76 | 78272 | 7244 | 46600470 |
Cardioactive drug level decreased | 74.63 | 10.42 | 20 | 78328 | 86 | 46607628 |
Therapeutic product effect decreased | 74.39 | 10.42 | 23 | 78325 | 82578 | 46525136 |
Oedema peripheral | 73.37 | 10.42 | 489 | 77859 | 159217 | 46448497 |
Musculoskeletal stiffness | 70.88 | 10.42 | 38 | 78310 | 97955 | 46509759 |
International normalised ratio decreased | 67.59 | 10.42 | 58 | 78290 | 4462 | 46603252 |
Nodal arrhythmia | 67.56 | 10.42 | 36 | 78312 | 1247 | 46606467 |
Atrial flutter | 67.44 | 10.42 | 80 | 78268 | 9068 | 46598646 |
Myocardial infarction | 67.38 | 10.42 | 333 | 78015 | 97195 | 46510519 |
Cardiac arrest | 67.02 | 10.42 | 315 | 78033 | 90084 | 46517630 |
Drug level increased | 65.64 | 10.42 | 114 | 78234 | 18327 | 46589387 |
Psoriasis | 65.40 | 10.42 | 25 | 78323 | 78579 | 46529135 |
Cerebral haemorrhage | 64.15 | 10.42 | 145 | 78203 | 28226 | 46579488 |
Fluid retention | 64.06 | 10.42 | 210 | 78138 | 50836 | 46556878 |
Contraindicated product administered | 63.95 | 10.42 | 27 | 78321 | 79920 | 46527794 |
Infusion related reaction | 63.86 | 10.42 | 46 | 78302 | 101162 | 46506552 |
Confusional state | 63.16 | 10.42 | 472 | 77876 | 159420 | 46448294 |
Pruritus | 62.22 | 10.42 | 204 | 78144 | 242148 | 46365566 |
Febrile neutropenia | 61.03 | 10.42 | 42 | 78306 | 94585 | 46513129 |
Sinus bradycardia | 60.97 | 10.42 | 94 | 78254 | 13688 | 46594026 |
Asthenia | 60.63 | 10.42 | 792 | 77556 | 310283 | 46297431 |
Cerebrovascular accident | 60.13 | 10.42 | 331 | 78017 | 100708 | 46507006 |
Presyncope | 59.83 | 10.42 | 129 | 78219 | 24325 | 46583389 |
Sinusitis | 59.81 | 10.42 | 78 | 78270 | 129690 | 46478024 |
Haemorrhage intracranial | 59.42 | 10.42 | 89 | 78259 | 12635 | 46595079 |
Injection site reaction | 58.77 | 10.42 | 6 | 78342 | 47843 | 46559871 |
Paraesthesia | 57.90 | 10.42 | 67 | 78281 | 117370 | 46490344 |
Atrioventricular block second degree | 57.32 | 10.42 | 49 | 78299 | 3750 | 46603964 |
Systemic lupus erythematosus | 57.18 | 10.42 | 19 | 78329 | 65161 | 46542553 |
Tachyarrhythmia | 56.53 | 10.42 | 53 | 78295 | 4579 | 46603135 |
Ventricular fibrillation | 55.97 | 10.42 | 82 | 78266 | 11414 | 46596300 |
Therapeutic product effect incomplete | 55.51 | 10.42 | 31 | 78317 | 78122 | 46529592 |
Rectal haemorrhage | 55.02 | 10.42 | 165 | 78183 | 38090 | 46569624 |
Prothrombin time prolonged | 54.98 | 10.42 | 74 | 78274 | 9522 | 46598192 |
Anaemia | 54.83 | 10.42 | 663 | 77685 | 255116 | 46352598 |
Orthopnoea | 54.61 | 10.42 | 58 | 78290 | 5822 | 46601892 |
Hypoxia | 54.41 | 10.42 | 201 | 78147 | 51637 | 46556077 |
Electrocardiogram ST segment depression | 53.94 | 10.42 | 41 | 78307 | 2652 | 46605062 |
Ischaemic stroke | 53.90 | 10.42 | 99 | 78249 | 16623 | 46591091 |
Dehydration | 51.61 | 10.42 | 450 | 77898 | 159090 | 46448624 |
Injection site pruritus | 51.47 | 10.42 | 4 | 78344 | 39739 | 46567975 |
Neutropenia | 51.03 | 10.42 | 102 | 78246 | 143102 | 46464612 |
Cardiomegaly | 50.78 | 10.42 | 99 | 78249 | 17383 | 46590331 |
Nasopharyngitis | 50.45 | 10.42 | 115 | 78233 | 153883 | 46453831 |
Sinus node dysfunction | 50.29 | 10.42 | 48 | 78300 | 4241 | 46603473 |
Haematoma | 50.18 | 10.42 | 142 | 78206 | 31730 | 46575984 |
Blood creatinine increased | 49.33 | 10.42 | 256 | 78092 | 76147 | 46531567 |
Suicidal ideation | 48.48 | 10.42 | 17 | 78331 | 56365 | 46551349 |
Blood urea increased | 48.06 | 10.42 | 121 | 78227 | 25231 | 46582483 |
Hypersensitivity | 47.84 | 10.42 | 114 | 78234 | 150207 | 46457507 |
Abdominal wall haematoma | 47.26 | 10.42 | 39 | 78309 | 2842 | 46604872 |
Injection site swelling | 47.16 | 10.42 | 6 | 78342 | 40321 | 46567393 |
Multiple sclerosis relapse | 45.29 | 10.42 | 8 | 78340 | 42117 | 46565597 |
Overdose | 44.25 | 10.42 | 308 | 78040 | 101671 | 46506043 |
Ventricular extrasystoles | 44.17 | 10.42 | 72 | 78276 | 10991 | 46596723 |
Heart rate decreased | 43.90 | 10.42 | 135 | 78213 | 31588 | 46576126 |
Renal injury | 43.51 | 10.42 | 66 | 78282 | 9475 | 46598239 |
Ventricular arrhythmia | 43.40 | 10.42 | 40 | 78308 | 3381 | 46604333 |
Hyponatraemia | 43.35 | 10.42 | 305 | 78043 | 101027 | 46506687 |
Hand deformity | 43.34 | 10.42 | 4 | 78344 | 34570 | 46573144 |
Blood potassium increased | 43.23 | 10.42 | 91 | 78257 | 16876 | 46590838 |
Arthropathy | 43.19 | 10.42 | 47 | 78301 | 84653 | 46523061 |
Dyspnoea exertional | 43.10 | 10.42 | 183 | 78165 | 50106 | 46557608 |
Dizziness | 43.06 | 10.42 | 806 | 77542 | 339608 | 46268106 |
Activated partial thromboplastin time prolonged | 42.36 | 10.42 | 55 | 78293 | 6834 | 46600880 |
Leukopenia | 41.89 | 10.42 | 32 | 78316 | 68311 | 46539403 |
Atrial tachycardia | 41.85 | 10.42 | 32 | 78316 | 2088 | 46605626 |
Stomatitis | 41.83 | 10.42 | 32 | 78316 | 68265 | 46539449 |
Tricuspid valve incompetence | 41.45 | 10.42 | 79 | 78269 | 13638 | 46594076 |
Fibromyalgia | 41.28 | 10.42 | 6 | 78342 | 36457 | 46571257 |
Urticaria | 41.12 | 10.42 | 85 | 78263 | 117807 | 46489907 |
Drug therapeutic incompatibility | 40.37 | 10.42 | 11 | 78337 | 51 | 46607663 |
Electrocardiogram QT prolonged | 40.35 | 10.42 | 182 | 78166 | 51143 | 46556571 |
Oedema | 40.07 | 10.42 | 220 | 78128 | 66851 | 46540863 |
Hypoglycaemia | 39.25 | 10.42 | 188 | 78160 | 54161 | 46553553 |
White blood cell count decreased | 39.07 | 10.42 | 81 | 78267 | 112150 | 46495564 |
Cardiac failure chronic | 38.61 | 10.42 | 38 | 78310 | 3486 | 46604228 |
Electrocardiogram abnormal | 38.54 | 10.42 | 53 | 78295 | 6959 | 46600755 |
Decreased appetite | 38.29 | 10.42 | 495 | 77853 | 193341 | 46414373 |
Arthritis | 38.22 | 10.42 | 44 | 78304 | 77272 | 46530442 |
Neuropathy peripheral | 37.55 | 10.42 | 59 | 78289 | 90834 | 46516880 |
Cardiogenic shock | 37.33 | 10.42 | 84 | 78264 | 16300 | 46591414 |
Asthma | 37.27 | 10.42 | 60 | 78288 | 91482 | 46516232 |
Supraventricular tachycardia | 37.15 | 10.42 | 74 | 78274 | 13196 | 46594518 |
Bundle branch block right | 36.94 | 10.42 | 43 | 78305 | 4776 | 46602938 |
Coagulopathy | 36.86 | 10.42 | 90 | 78258 | 18409 | 46589305 |
Mitral valve incompetence | 36.80 | 10.42 | 91 | 78257 | 18761 | 46588953 |
Migraine | 36.66 | 10.42 | 38 | 78310 | 69988 | 46537726 |
Electrocardiogram QT shortened | 36.31 | 10.42 | 12 | 78336 | 118 | 46607596 |
Intentional product use issue | 35.96 | 10.42 | 22 | 78326 | 52758 | 46554956 |
Pleural effusion | 35.66 | 10.42 | 250 | 78098 | 82702 | 46525012 |
Glossodynia | 35.45 | 10.42 | 15 | 78333 | 44358 | 46563356 |
Product use issue | 34.93 | 10.42 | 66 | 78282 | 94578 | 46513136 |
Psoriatic arthropathy | 34.84 | 10.42 | 9 | 78339 | 36370 | 46571344 |
Headache | 34.57 | 10.42 | 580 | 77768 | 477772 | 46129942 |
Heart rate irregular | 34.47 | 10.42 | 88 | 78260 | 18503 | 46589211 |
Depression | 34.11 | 10.42 | 158 | 78190 | 169946 | 46437768 |
Embolic stroke | 33.98 | 10.42 | 36 | 78312 | 3603 | 46604111 |
Insomnia | 33.78 | 10.42 | 152 | 78196 | 164772 | 46442942 |
Xanthopsia | 33.58 | 10.42 | 12 | 78336 | 152 | 46607562 |
Cardioactive drug level below therapeutic | 33.42 | 10.42 | 7 | 78341 | 6 | 46607708 |
Medication error | 33.39 | 10.42 | 121 | 78227 | 30790 | 46576924 |
Atrioventricular dissociation | 33.38 | 10.42 | 13 | 78335 | 212 | 46607502 |
Hypocoagulable state | 32.86 | 10.42 | 21 | 78327 | 1026 | 46606688 |
Cardiac failure acute | 32.83 | 10.42 | 53 | 78295 | 8025 | 46599689 |
Hypoaesthesia | 32.61 | 10.42 | 97 | 78251 | 118772 | 46488942 |
Epistaxis | 32.61 | 10.42 | 202 | 78146 | 64103 | 46543611 |
Back pain | 32.32 | 10.42 | 213 | 78135 | 209826 | 46397888 |
Electrocardiogram ST segment abnormal | 31.57 | 10.42 | 20 | 78328 | 962 | 46606752 |
Sleep disorder | 31.20 | 10.42 | 20 | 78328 | 46775 | 46560939 |
Pulmonary arterial pressure increased | 31.18 | 10.42 | 33 | 78315 | 3299 | 46604415 |
Neutrophil count decreased | 31.15 | 10.42 | 17 | 78331 | 43409 | 46564305 |
Chest pain | 31.00 | 10.42 | 441 | 77907 | 175883 | 46431831 |
Transfusion | 30.33 | 10.42 | 68 | 78280 | 13163 | 46594551 |
Ejection fraction decreased | 30.29 | 10.42 | 82 | 78266 | 17855 | 46589859 |
Pulmonary oedema | 30.09 | 10.42 | 167 | 78181 | 50938 | 46556776 |
Herpes zoster | 30.03 | 10.42 | 42 | 78306 | 67830 | 46539884 |
Intentional self-injury | 29.75 | 10.42 | 3 | 78345 | 24163 | 46583551 |
Palpitations | 29.38 | 10.42 | 266 | 78082 | 94993 | 46512721 |
Fall | 29.32 | 10.42 | 741 | 77607 | 328356 | 46279358 |
Cor pulmonale | 29.19 | 10.42 | 25 | 78323 | 1918 | 46605796 |
Bundle branch block left | 28.80 | 10.42 | 44 | 78304 | 6355 | 46601359 |
Respiratory failure | 28.35 | 10.42 | 263 | 78085 | 94553 | 46513161 |
Renal impairment | 27.89 | 10.42 | 217 | 78131 | 74155 | 46533559 |
Left ventricular failure | 27.85 | 10.42 | 38 | 78310 | 4952 | 46602762 |
Shock haemorrhagic | 27.72 | 10.42 | 51 | 78297 | 8573 | 46599141 |
Death | 27.71 | 10.42 | 748 | 77600 | 334800 | 46272914 |
Intentional product misuse | 27.70 | 10.42 | 23 | 78325 | 47105 | 46560609 |
Wound | 27.58 | 10.42 | 19 | 78329 | 42783 | 46564931 |
Pyrexia | 27.46 | 10.42 | 416 | 77932 | 348386 | 46259328 |
Infection | 27.42 | 10.42 | 123 | 78225 | 133469 | 46474245 |
Muscle spasms | 27.33 | 10.42 | 110 | 78238 | 123003 | 46484711 |
Cardiomyopathy | 26.67 | 10.42 | 73 | 78275 | 16000 | 46591714 |
Coagulation time prolonged | 26.31 | 10.42 | 20 | 78328 | 1294 | 46606420 |
Oropharyngeal pain | 26.25 | 10.42 | 53 | 78295 | 74115 | 46533599 |
Drug monitoring procedure not performed | 26.17 | 10.42 | 13 | 78335 | 388 | 46607326 |
Pain in extremity | 26.05 | 10.42 | 293 | 78055 | 258387 | 46349327 |
Cardiac disorder | 25.61 | 10.42 | 143 | 78205 | 43715 | 46563999 |
Brain natriuretic peptide increased | 25.34 | 10.42 | 35 | 78313 | 4615 | 46603099 |
Multiple organ dysfunction syndrome | 25.32 | 10.42 | 161 | 78187 | 51549 | 46556165 |
Product dose omission issue | 24.86 | 10.42 | 173 | 78175 | 168347 | 46439367 |
Hypochromic anaemia | 24.75 | 10.42 | 20 | 78328 | 1415 | 46606299 |
Fatigue | 24.59 | 10.42 | 807 | 77541 | 607890 | 45999824 |
Urine output decreased | 24.29 | 10.42 | 56 | 78292 | 11041 | 46596673 |
Intentional overdose | 24.21 | 10.42 | 45 | 78303 | 64899 | 46542815 |
Malignant neoplasm progression | 24.19 | 10.42 | 45 | 78303 | 64881 | 46542833 |
Musculoskeletal pain | 24.07 | 10.42 | 51 | 78297 | 70077 | 46537637 |
Rheumatoid factor positive | 24.03 | 10.42 | 3 | 78345 | 20458 | 46587256 |
Chromatopsia | 23.54 | 10.42 | 13 | 78335 | 484 | 46607230 |
Cardiac pacemaker insertion | 23.47 | 10.42 | 30 | 78318 | 3669 | 46604045 |
Erythrodermic psoriasis | 23.45 | 10.42 | 16 | 78332 | 873 | 46606841 |
Hyperthyroidism | 23.36 | 10.42 | 57 | 78291 | 11654 | 46596060 |
Myocardial ischaemia | 23.28 | 10.42 | 60 | 78288 | 12689 | 46595025 |
Drug level above therapeutic | 23.13 | 10.42 | 29 | 78319 | 3480 | 46604234 |
Hepatic enzyme increased | 22.96 | 10.42 | 66 | 78282 | 81721 | 46525993 |
Tremor | 22.82 | 10.42 | 108 | 78240 | 115531 | 46492183 |
Extrasystoles | 22.65 | 10.42 | 34 | 78314 | 4835 | 46602879 |
Mitral valve stenosis | 22.33 | 10.42 | 17 | 78331 | 1102 | 46606612 |
Pulse absent | 22.20 | 10.42 | 34 | 78314 | 4922 | 46602792 |
Loss of consciousness | 22.01 | 10.42 | 278 | 78070 | 107960 | 46499754 |
Disorientation | 21.97 | 10.42 | 121 | 78227 | 36797 | 46570917 |
Acute respiratory failure | 21.91 | 10.42 | 102 | 78246 | 29036 | 46578678 |
Wrong technique in product usage process | 21.84 | 10.42 | 36 | 78312 | 54386 | 46553328 |
Catheter management | 21.53 | 10.42 | 25 | 78323 | 2770 | 46604944 |
Stupor | 21.48 | 10.42 | 28 | 78320 | 3492 | 46604222 |
Toxic epidermal necrolysis | 21.40 | 10.42 | 84 | 78264 | 22194 | 46585520 |
Osteoporosis | 21.29 | 10.42 | 22 | 78326 | 40586 | 46567128 |
Accidental overdose | 21.21 | 10.42 | 78 | 78270 | 19988 | 46587726 |
Product use in unapproved indication | 21.09 | 10.42 | 79 | 78269 | 90194 | 46517520 |
Creatinine renal clearance decreased | 21.09 | 10.42 | 40 | 78308 | 6880 | 46600834 |
Coronary artery disease | 21.02 | 10.42 | 112 | 78236 | 33640 | 46574074 |
Mobility decreased | 20.85 | 10.42 | 44 | 78304 | 60550 | 46547164 |
Congestive hepatopathy | 20.65 | 10.42 | 23 | 78325 | 2435 | 46605279 |
Oxygen consumption increased | 20.60 | 10.42 | 28 | 78320 | 3635 | 46604079 |
Haemoglobin decreased | 20.49 | 10.42 | 317 | 78031 | 128632 | 46479082 |
Anxiety | 20.37 | 10.42 | 201 | 78147 | 181756 | 46425958 |
Joint stiffness | 20.35 | 10.42 | 10 | 78338 | 27098 | 46580616 |
Retroperitoneal haemorrhage | 20.33 | 10.42 | 24 | 78324 | 2706 | 46605008 |
Unevaluable event | 20.32 | 10.42 | 140 | 78208 | 46035 | 46561679 |
Haematemesis | 20.32 | 10.42 | 99 | 78249 | 28707 | 46579007 |
Hypertension | 20.31 | 10.42 | 221 | 78127 | 196135 | 46411579 |
Splenic injury | 20.31 | 10.42 | 9 | 78339 | 206 | 46607508 |
Swelling | 20.29 | 10.42 | 124 | 78224 | 124387 | 46483327 |
Alveolitis | 20.23 | 10.42 | 23 | 78325 | 2490 | 46605224 |
Subarachnoid haemorrhage | 19.86 | 10.42 | 52 | 78296 | 11101 | 46596613 |
Dilatation ventricular | 19.84 | 10.42 | 23 | 78325 | 2544 | 46605170 |
Therapeutic response decreased | 19.79 | 10.42 | 26 | 78322 | 43119 | 46564595 |
Aortic valve calcification | 19.76 | 10.42 | 11 | 78337 | 416 | 46607298 |
Suicide attempt | 19.76 | 10.42 | 39 | 78309 | 54997 | 46552717 |
Occult blood positive | 19.64 | 10.42 | 27 | 78321 | 3543 | 46604171 |
Central nervous system injury | 19.52 | 10.42 | 8 | 78340 | 150 | 46607564 |
Prothrombin time shortened | 19.33 | 10.42 | 19 | 78329 | 1740 | 46605974 |
Neuralgia | 19.16 | 10.42 | 6 | 78342 | 21377 | 46586337 |
Metabolic acidosis | 19.14 | 10.42 | 121 | 78227 | 38659 | 46569055 |
Potentiating drug interaction | 19.12 | 10.42 | 28 | 78320 | 3895 | 46603819 |
Oliguria | 18.95 | 10.42 | 44 | 78304 | 8715 | 46598999 |
Drug dependence | 18.91 | 10.42 | 5 | 78343 | 19896 | 46587818 |
Pyroglutamic acidosis | 18.78 | 10.42 | 9 | 78339 | 248 | 46607466 |
Chills | 18.76 | 10.42 | 90 | 78258 | 95942 | 46511772 |
Anaphylactic reaction | 18.75 | 10.42 | 38 | 78310 | 53074 | 46554640 |
Haematuria | 18.73 | 10.42 | 92 | 78256 | 26766 | 46580948 |
Pulmonary congestion | 18.66 | 10.42 | 61 | 78287 | 14738 | 46592976 |
Maternal exposure during pregnancy | 18.39 | 10.42 | 99 | 78249 | 102450 | 46505264 |
Lymphocyte count decreased | 18.38 | 10.42 | 10 | 78338 | 25579 | 46582135 |
Fear | 18.05 | 10.42 | 64 | 78284 | 16108 | 46591606 |
Inappropriate schedule of product administration | 17.86 | 10.42 | 53 | 78295 | 64960 | 46542754 |
Blood pressure decreased | 17.81 | 10.42 | 160 | 78188 | 56999 | 46550715 |
Dilatation atrial | 17.81 | 10.42 | 20 | 78328 | 2137 | 46605577 |
Packed red blood cell transfusion | 17.76 | 10.42 | 20 | 78328 | 2143 | 46605571 |
Electrocardiogram PR prolongation | 17.72 | 10.42 | 12 | 78336 | 647 | 46607067 |
Hypochromasia | 17.69 | 10.42 | 9 | 78339 | 283 | 46607431 |
Hypovolaemia | 17.50 | 10.42 | 46 | 78302 | 9842 | 46597872 |
Knee arthroplasty | 17.36 | 10.42 | 9 | 78339 | 23656 | 46584058 |
Cardiac murmur | 17.16 | 10.42 | 50 | 78298 | 11354 | 46596360 |
Conduction disorder | 17.07 | 10.42 | 16 | 78332 | 1382 | 46606332 |
Subcutaneous haematoma | 17.05 | 10.42 | 17 | 78331 | 1584 | 46606130 |
Exposure during pregnancy | 16.99 | 10.42 | 109 | 78239 | 108103 | 46499611 |
Abdominal discomfort | 16.91 | 10.42 | 167 | 78181 | 150998 | 46456716 |
Left atrial dilatation | 16.88 | 10.42 | 18 | 78330 | 1815 | 46605899 |
Lethargy | 16.86 | 10.42 | 145 | 78203 | 51026 | 46556688 |
Device related infection | 16.82 | 10.42 | 75 | 78273 | 20966 | 46586748 |
Haemorrhage | 16.79 | 10.42 | 153 | 78195 | 54716 | 46552998 |
Osteoarthritis | 16.72 | 10.42 | 51 | 78297 | 61974 | 46545740 |
Brain stem haemorrhage | 16.71 | 10.42 | 12 | 78336 | 711 | 46607003 |
Supraventricular extrasystoles | 16.65 | 10.42 | 27 | 78321 | 4102 | 46603612 |
Anticoagulation drug level above therapeutic | 16.64 | 10.42 | 15 | 78333 | 1232 | 46606482 |
Serotonin syndrome | 16.63 | 10.42 | 10 | 78338 | 24210 | 46583504 |
Deep vein thrombosis | 16.63 | 10.42 | 73 | 78275 | 79700 | 46528014 |
Fungal infection | 16.63 | 10.42 | 15 | 78333 | 29505 | 46578209 |
Transplant evaluation | 16.48 | 10.42 | 14 | 78334 | 1062 | 46606652 |
Electrocardiogram repolarisation abnormality | 16.45 | 10.42 | 15 | 78333 | 1250 | 46606464 |
Rheumatic heart disease | 16.30 | 10.42 | 4 | 78344 | 11 | 46607703 |
Cerebral infarction | 16.27 | 10.42 | 80 | 78268 | 23286 | 46584428 |
Pericarditis | 16.26 | 10.42 | 10 | 78338 | 23917 | 46583797 |
Cardiopulmonary bypass | 16.18 | 10.42 | 3 | 78345 | 0 | 46607714 |
Pneumocystis jirovecii pneumonia | 16.16 | 10.42 | 3 | 78345 | 15245 | 46592469 |
Lung transplant | 16.11 | 10.42 | 22 | 78326 | 2870 | 46604844 |
Sopor | 16.09 | 10.42 | 71 | 78277 | 19757 | 46587957 |
Constipation | 16.04 | 10.42 | 201 | 78147 | 173896 | 46433818 |
Electrocardiogram QRS complex prolonged | 15.99 | 10.42 | 31 | 78317 | 5418 | 46602296 |
Irritability | 15.96 | 10.42 | 15 | 78333 | 28931 | 46578783 |
Rhythm idioventricular | 15.81 | 10.42 | 7 | 78341 | 160 | 46607554 |
Neoplasm progression | 15.71 | 10.42 | 13 | 78335 | 26670 | 46581044 |
Seizure | 15.47 | 10.42 | 132 | 78216 | 122922 | 46484792 |
Left ventricular dysfunction | 15.47 | 10.42 | 45 | 78303 | 10210 | 46597504 |
Ventricular hypertrophy | 15.47 | 10.42 | 25 | 78323 | 3789 | 46603925 |
Transient ischaemic attack | 15.46 | 10.42 | 106 | 78242 | 34797 | 46572917 |
Loss of personal independence in daily activities | 15.43 | 10.42 | 47 | 78301 | 57136 | 46550578 |
Depressed mood | 15.36 | 10.42 | 20 | 78328 | 33299 | 46574415 |
Hypoglycaemic seizure | 15.30 | 10.42 | 10 | 78338 | 508 | 46607206 |
Haemoptysis | 15.03 | 10.42 | 85 | 78263 | 26104 | 46581610 |
Ventricular dysfunction | 14.96 | 10.42 | 21 | 78327 | 2811 | 46604903 |
Dialysis | 14.89 | 10.42 | 44 | 78304 | 10072 | 46597642 |
Cytomegalovirus infection | 14.71 | 10.42 | 6 | 78342 | 18138 | 46589576 |
Multiple sclerosis | 14.69 | 10.42 | 12 | 78336 | 24779 | 46582935 |
Right ventricular systolic pressure increased | 14.69 | 10.42 | 10 | 78338 | 544 | 46607170 |
Obesity | 14.63 | 10.42 | 3 | 78345 | 14203 | 46593511 |
Ecchymosis | 14.62 | 10.42 | 45 | 78303 | 10531 | 46597183 |
Electrocardiogram R on T phenomenon | 14.43 | 10.42 | 4 | 78344 | 20 | 46607694 |
Foot deformity | 14.42 | 10.42 | 4 | 78344 | 15421 | 46592293 |
Panic attack | 14.41 | 10.42 | 8 | 78340 | 20234 | 46587480 |
No adverse event | 14.34 | 10.42 | 22 | 78326 | 34209 | 46573505 |
Choroidal haemorrhage | 14.31 | 10.42 | 5 | 78343 | 59 | 46607655 |
Iron deficiency anaemia | 14.26 | 10.42 | 62 | 78286 | 17144 | 46590570 |
Oxygen saturation decreased | 14.21 | 10.42 | 178 | 78170 | 68986 | 46538728 |
Colitis ulcerative | 14.15 | 10.42 | 6 | 78342 | 17726 | 46589988 |
Mitral valve disease | 14.13 | 10.42 | 18 | 78330 | 2194 | 46605520 |
Basal ganglia haemorrhage | 13.93 | 10.42 | 10 | 78338 | 592 | 46607122 |
Labelled drug-drug interaction medication error | 13.90 | 10.42 | 40 | 78308 | 9021 | 46598693 |
Pregnancy | 13.89 | 10.42 | 15 | 78333 | 27122 | 46580592 |
Injection site mass | 13.87 | 10.42 | 4 | 78344 | 15036 | 46592678 |
Pain in jaw | 13.85 | 10.42 | 111 | 78237 | 38261 | 46569453 |
Blood cholesterol increased | 13.81 | 10.42 | 29 | 78319 | 39984 | 46567730 |
Bone pain | 13.78 | 10.42 | 37 | 78311 | 46853 | 46560861 |
Electrocardiogram change | 13.77 | 10.42 | 10 | 78338 | 603 | 46607111 |
Cardioversion | 13.71 | 10.42 | 13 | 78335 | 1139 | 46606575 |
Blood culture positive | 13.65 | 10.42 | 26 | 78322 | 4486 | 46603228 |
Cyanosis | 13.58 | 10.42 | 58 | 78290 | 15913 | 46591801 |
Osteonecrosis of jaw | 13.57 | 10.42 | 23 | 78325 | 34379 | 46573335 |
Blood bilirubin increased | 13.51 | 10.42 | 101 | 78247 | 34083 | 46573631 |
Abdominal tenderness | 13.48 | 10.42 | 34 | 78314 | 7094 | 46600620 |
Exercise tolerance decreased | 13.39 | 10.42 | 26 | 78322 | 4551 | 46603163 |
Coronary arterial stent insertion | 13.38 | 10.42 | 20 | 78328 | 2833 | 46604881 |
Blood loss anaemia | 13.34 | 10.42 | 38 | 78310 | 8519 | 46599195 |
Palmar-plantar erythrodysaesthesia syndrome | 13.28 | 10.42 | 9 | 78339 | 20442 | 46587272 |
Ischaemic cardiomyopathy | 13.26 | 10.42 | 19 | 78329 | 2591 | 46605123 |
Diabetic ketoacidosis | 13.25 | 10.42 | 7 | 78341 | 18203 | 46589511 |
Intervertebral disc protrusion | 13.22 | 10.42 | 9 | 78339 | 20396 | 46587318 |
Hip arthroplasty | 13.12 | 10.42 | 7 | 78341 | 18105 | 46589609 |
Prerenal failure | 13.04 | 10.42 | 14 | 78334 | 1423 | 46606291 |
Atrial thrombosis | 12.98 | 10.42 | 14 | 78334 | 1430 | 46606284 |
Right ventricular hypertrophy | 12.91 | 10.42 | 10 | 78338 | 665 | 46607049 |
Walking distance test abnormal | 12.91 | 10.42 | 9 | 78339 | 509 | 46607205 |
Faeces discoloured | 12.79 | 10.42 | 59 | 78289 | 16728 | 46590986 |
Depressed level of consciousness | 12.75 | 10.42 | 129 | 78219 | 47440 | 46560274 |
Hypomagnesaemia | 12.69 | 10.42 | 72 | 78276 | 22138 | 46585576 |
Calcium deficiency | 12.64 | 10.42 | 11 | 78337 | 862 | 46606852 |
Acne | 12.62 | 10.42 | 9 | 78339 | 19910 | 46587804 |
Ear infection | 12.60 | 10.42 | 12 | 78336 | 23001 | 46584713 |
Delirium | 12.53 | 10.42 | 106 | 78242 | 37122 | 46570592 |
Blood pressure increased | 12.52 | 10.42 | 144 | 78204 | 126522 | 46481192 |
Anhedonia | 12.49 | 10.42 | 42 | 78306 | 10293 | 46597421 |
Red blood cell sedimentation rate increased | 12.46 | 10.42 | 12 | 78336 | 22877 | 46584837 |
Pharyngitis | 12.44 | 10.42 | 7 | 78341 | 17576 | 46590138 |
Rales | 12.41 | 10.42 | 40 | 78308 | 9591 | 46598123 |
Hypersensitivity vasculitis | 12.37 | 10.42 | 24 | 78324 | 4197 | 46603517 |
Blood pressure fluctuation | 12.34 | 10.42 | 20 | 78328 | 30428 | 46577286 |
Orthostatic hypotension | 12.21 | 10.42 | 77 | 78271 | 24581 | 46583133 |
Chronic obstructive pulmonary disease | 12.13 | 10.42 | 149 | 78199 | 57484 | 46550230 |
Catheter site erythema | 12.11 | 10.42 | 23 | 78325 | 3960 | 46603754 |
Drug withdrawal syndrome | 12.06 | 10.42 | 17 | 78331 | 27367 | 46580347 |
Erythema | 12.02 | 10.42 | 168 | 78180 | 142652 | 46465062 |
Hypoglycaemic coma | 12.01 | 10.42 | 18 | 78330 | 2556 | 46605158 |
Thromboembolectomy | 11.95 | 10.42 | 4 | 78344 | 41 | 46607673 |
Catheter site rash | 11.94 | 10.42 | 10 | 78338 | 744 | 46606970 |
Anisocytosis | 11.91 | 10.42 | 9 | 78339 | 577 | 46607137 |
Paracentesis | 11.89 | 10.42 | 11 | 78337 | 934 | 46606780 |
Therapeutic response increased | 11.89 | 10.42 | 7 | 78341 | 295 | 46607419 |
Cataract | 11.78 | 10.42 | 38 | 78310 | 45377 | 46562337 |
Aortic stenosis | 11.74 | 10.42 | 24 | 78324 | 4358 | 46603356 |
Haemodialysis | 11.63 | 10.42 | 38 | 78310 | 9179 | 46598535 |
Injection site rash | 11.62 | 10.42 | 6 | 78342 | 15807 | 46591907 |
Venous pressure jugular increased | 11.61 | 10.42 | 8 | 78340 | 444 | 46607270 |
Peripheral swelling | 11.57 | 10.42 | 191 | 78157 | 157880 | 46449834 |
Impaired healing | 11.56 | 10.42 | 28 | 78320 | 36715 | 46570999 |
Diabetic metabolic decompensation | 11.56 | 10.42 | 12 | 78336 | 1173 | 46606541 |
Cardiorenal syndrome | 11.46 | 10.42 | 9 | 78339 | 611 | 46607103 |
Dizziness postural | 11.42 | 10.42 | 30 | 78318 | 6416 | 46601298 |
Concomitant disease progression | 11.37 | 10.42 | 16 | 78332 | 2146 | 46605568 |
Respiratory distress | 11.34 | 10.42 | 92 | 78256 | 31824 | 46575890 |
Dry eye | 11.31 | 10.42 | 21 | 78327 | 30301 | 46577413 |
Mucosal inflammation | 11.27 | 10.42 | 31 | 78317 | 38945 | 46568769 |
Anger | 11.22 | 10.42 | 3 | 78345 | 11849 | 46595865 |
Blood pressure immeasurable | 11.21 | 10.42 | 12 | 78336 | 1215 | 46606499 |
Breast cancer | 11.18 | 10.42 | 39 | 78309 | 45479 | 46562235 |
Paralysis | 11.04 | 10.42 | 36 | 78312 | 8685 | 46599029 |
Foot fracture | 10.97 | 10.42 | 10 | 78338 | 19572 | 46588142 |
Catheter site pruritus | 10.94 | 10.42 | 15 | 78333 | 1964 | 46605750 |
Polyneuropathy | 10.92 | 10.42 | 3 | 78345 | 11641 | 46596073 |
Cardiac valve disease | 10.89 | 10.42 | 22 | 78326 | 3962 | 46603752 |
Haematocrit decreased | 10.85 | 10.42 | 98 | 78250 | 34959 | 46572755 |
Adams-Stokes syndrome | 10.83 | 10.42 | 4 | 78344 | 56 | 46607658 |
Microcytic anaemia | 10.82 | 10.42 | 19 | 78329 | 3079 | 46604635 |
C-reactive protein increased | 10.81 | 10.42 | 56 | 78292 | 58534 | 46549180 |
Aortic valve incompetence | 10.80 | 10.42 | 28 | 78320 | 5942 | 46601772 |
Acute myocardial infarction | 10.79 | 10.42 | 91 | 78257 | 31833 | 46575881 |
Ventricular failure | 10.72 | 10.42 | 7 | 78341 | 355 | 46607359 |
Azotaemia | 10.69 | 10.42 | 23 | 78325 | 4328 | 46603386 |
Lactic acidosis | 10.60 | 10.42 | 95 | 78253 | 33814 | 46573900 |
Hyperchloraemia | 10.58 | 10.42 | 9 | 78339 | 684 | 46607030 |
Heart sounds abnormal | 10.57 | 10.42 | 9 | 78339 | 685 | 46607029 |
Nephrolithiasis | 10.55 | 10.42 | 25 | 78323 | 33026 | 46574688 |
Prothrombin level increased | 10.54 | 10.42 | 6 | 78342 | 237 | 46607477 |
Cough | 10.52 | 10.42 | 300 | 78048 | 229949 | 46377765 |
Cerebellar haematoma | 10.51 | 10.42 | 7 | 78341 | 367 | 46607347 |
Hepatic steatosis | 10.51 | 10.42 | 15 | 78333 | 24027 | 46583687 |
Upper respiratory tract infection | 10.50 | 10.42 | 63 | 78285 | 63493 | 46544221 |
Blood alkaline phosphatase increased | 10.42 | 10.42 | 107 | 78241 | 39502 | 46568212 |
MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
---|---|---|---|---|---|---|
Cardioactive drug level increased | 770.38 | 10.84 | 241 | 67167 | 1398 | 29883672 |
Bradycardia | 649.68 | 10.84 | 768 | 66640 | 64758 | 29820312 |
Cardiac failure congestive | 576.59 | 10.84 | 823 | 66585 | 83584 | 29801486 |
Atrial fibrillation | 535.63 | 10.84 | 909 | 66499 | 107215 | 29777855 |
International normalised ratio increased | 524.07 | 10.84 | 590 | 66818 | 47149 | 29837921 |
Ventricular tachycardia | 243.11 | 10.84 | 284 | 67124 | 23578 | 29861492 |
Cardiac failure | 226.67 | 10.84 | 547 | 66861 | 82871 | 29802199 |
Hyperkalaemia | 180.45 | 10.84 | 434 | 66974 | 65576 | 29819494 |
Product complaint | 157.03 | 10.84 | 119 | 67289 | 5687 | 29879383 |
Toxicity to various agents | 156.98 | 10.84 | 800 | 66608 | 176383 | 29708687 |
Drug abuse | 155.03 | 10.84 | 7 | 67401 | 82065 | 29803005 |
Off label use | 146.58 | 10.84 | 209 | 67199 | 249081 | 29635989 |
Gastrointestinal haemorrhage | 122.90 | 10.84 | 440 | 66968 | 83006 | 29802064 |
Drug ineffective | 121.46 | 10.84 | 379 | 67029 | 340008 | 29545062 |
Drug interaction | 116.00 | 10.84 | 807 | 66601 | 198761 | 29686309 |
Venous pressure jugular increased | 113.48 | 10.84 | 47 | 67361 | 664 | 29884406 |
Cardiac murmur | 89.78 | 10.84 | 93 | 67315 | 6741 | 29878329 |
Hypotension | 88.59 | 10.84 | 761 | 66647 | 199804 | 29685266 |
Acute kidney injury | 87.21 | 10.84 | 970 | 66438 | 272872 | 29612198 |
Right ventricular failure | 84.06 | 10.84 | 97 | 67311 | 7939 | 29877131 |
Dyspnoea | 82.99 | 10.84 | 1127 | 66281 | 332168 | 29552902 |
Cardioactive drug level above therapeutic | 82.51 | 10.84 | 21 | 67387 | 47 | 29885023 |
Atrial flutter | 78.35 | 10.84 | 126 | 67282 | 14155 | 29870915 |
Melaena | 77.74 | 10.84 | 203 | 67205 | 32234 | 29852836 |
Myocardial infarction | 73.98 | 10.84 | 510 | 66898 | 125115 | 29759955 |
Ischaemic cardiomyopathy | 70.94 | 10.84 | 79 | 67329 | 6218 | 29878852 |
Febrile neutropenia | 69.13 | 10.84 | 83 | 67325 | 106610 | 29778460 |
Nodal rhythm | 66.75 | 10.84 | 41 | 67367 | 1382 | 29883688 |
Neutropenia | 66.59 | 10.84 | 117 | 67291 | 128423 | 29756647 |
Ventricular fibrillation | 66.48 | 10.84 | 121 | 67287 | 15017 | 29870053 |
Bradyarrhythmia | 66.44 | 10.84 | 46 | 67362 | 1906 | 29883164 |
Cardiac arrest | 65.09 | 10.84 | 394 | 67014 | 92456 | 29792614 |
Arrhythmia | 65.09 | 10.84 | 193 | 67215 | 32976 | 29852094 |
Dizziness | 64.92 | 10.84 | 697 | 66711 | 194212 | 29690858 |
Cardioactive drug level decreased | 61.81 | 10.84 | 17 | 67391 | 57 | 29885013 |
Pulmonary hypertension | 59.44 | 10.84 | 132 | 67276 | 18904 | 29866166 |
Ventricular extrasystoles | 58.57 | 10.84 | 98 | 67310 | 11376 | 29873694 |
Product dose omission issue | 55.49 | 10.84 | 75 | 67333 | 91556 | 29793514 |
Product use in unapproved indication | 52.48 | 10.84 | 53 | 67355 | 73640 | 29811430 |
Tricuspid valve incompetence | 51.34 | 10.84 | 79 | 67329 | 8544 | 29876526 |
Cardiomegaly | 50.34 | 10.84 | 105 | 67303 | 14404 | 29870666 |
Prothrombin time prolonged | 49.55 | 10.84 | 81 | 67327 | 9222 | 29875848 |
Atrioventricular block | 49.51 | 10.84 | 71 | 67337 | 7211 | 29877859 |
Rheumatoid arthritis | 48.65 | 10.84 | 16 | 67392 | 41181 | 29843889 |
Xanthopsia | 47.98 | 10.84 | 17 | 67391 | 152 | 29884918 |
Pyrexia | 47.57 | 10.84 | 429 | 66979 | 294060 | 29591010 |
International normalised ratio decreased | 47.32 | 10.84 | 55 | 67353 | 4535 | 29880535 |
Atrioventricular block complete | 46.77 | 10.84 | 75 | 67333 | 8402 | 29876668 |
Mitral valve incompetence | 45.01 | 10.84 | 95 | 67313 | 13139 | 29871931 |
Rash | 44.89 | 10.84 | 251 | 67157 | 191638 | 29693432 |
Left ventricular dysfunction | 44.05 | 10.84 | 74 | 67334 | 8617 | 29876453 |
Heart rate irregular | 44.03 | 10.84 | 90 | 67318 | 12169 | 29872901 |
Cardiogenic shock | 44.00 | 10.84 | 109 | 67299 | 16752 | 29868318 |
Subdural haematoma | 43.68 | 10.84 | 117 | 67291 | 18855 | 29866215 |
Drug hypersensitivity | 43.62 | 10.84 | 54 | 67354 | 68465 | 29816605 |
Arthralgia | 43.53 | 10.84 | 158 | 67250 | 135633 | 29749437 |
Torsade de pointes | 42.98 | 10.84 | 66 | 67342 | 7124 | 29877946 |
Coronary artery disease | 42.79 | 10.84 | 223 | 67185 | 49489 | 29835581 |
Renal failure | 42.76 | 10.84 | 461 | 66947 | 128505 | 29756565 |
Completed suicide | 41.82 | 10.84 | 102 | 67306 | 99390 | 29785680 |
Cardiomyopathy | 41.76 | 10.84 | 100 | 67308 | 15043 | 29870027 |
Cardiac failure chronic | 41.09 | 10.84 | 58 | 67350 | 5805 | 29879265 |
Confusional state | 41.07 | 10.84 | 474 | 66934 | 134360 | 29750710 |
Cerebrovascular accident | 40.59 | 10.84 | 324 | 67084 | 83153 | 29801917 |
Headache | 39.17 | 10.84 | 245 | 67163 | 182061 | 29703009 |
Intentional product use issue | 38.29 | 10.84 | 17 | 67391 | 36423 | 29848647 |
Pruritus | 38.23 | 10.84 | 137 | 67271 | 118067 | 29767003 |
Heart rate decreased | 38.21 | 10.84 | 119 | 67289 | 20875 | 29864195 |
Atrioventricular block first degree | 37.99 | 10.84 | 55 | 67353 | 5633 | 29879437 |
Sinus node dysfunction | 37.88 | 10.84 | 45 | 67363 | 3798 | 29881272 |
Left ventricular failure | 37.41 | 10.84 | 51 | 67357 | 4940 | 29880130 |
Asthenia | 37.33 | 10.84 | 702 | 66706 | 220588 | 29664482 |
Syncope | 36.73 | 10.84 | 321 | 67087 | 84582 | 29800488 |
Pulmonary arterial hypertension | 36.67 | 10.84 | 71 | 67337 | 9230 | 29875840 |
Haematuria | 36.45 | 10.84 | 198 | 67210 | 44636 | 29840434 |
Nodal arrhythmia | 35.94 | 10.84 | 23 | 67385 | 834 | 29884236 |
Ventricular arrhythmia | 35.50 | 10.84 | 46 | 67362 | 4242 | 29880828 |
Supraventricular tachycardia | 34.08 | 10.84 | 73 | 67335 | 10199 | 29874871 |
Blood urea increased | 33.66 | 10.84 | 150 | 67258 | 31231 | 29853839 |
Intentional product misuse | 33.65 | 10.84 | 18 | 67390 | 34649 | 29850421 |
Psoriasis | 33.29 | 10.84 | 28 | 67380 | 42478 | 29842592 |
Atrial tachycardia | 33.18 | 10.84 | 32 | 67376 | 2127 | 29882943 |
Leukopenia | 32.94 | 10.84 | 47 | 67361 | 56112 | 29828958 |
White blood cell count decreased | 32.26 | 10.84 | 90 | 67318 | 83857 | 29801213 |
Injection site pain | 32.06 | 10.84 | 14 | 67394 | 30296 | 29854774 |
Nasopharyngitis | 31.87 | 10.84 | 52 | 67356 | 58797 | 29826273 |
Blood lactic acid | 31.72 | 10.84 | 16 | 67392 | 364 | 29884706 |
Chronic obstructive pulmonary disease | 31.18 | 10.84 | 194 | 67214 | 45932 | 29839138 |
Neuropathy peripheral | 30.60 | 10.84 | 71 | 67337 | 70404 | 29814666 |
Coagulopathy | 30.21 | 10.84 | 101 | 67307 | 18386 | 29866684 |
Dissociation | 30.07 | 10.84 | 23 | 67385 | 1114 | 29883956 |
Cardiac disorder | 29.65 | 10.84 | 172 | 67236 | 39721 | 29845349 |
Ejection fraction decreased | 29.47 | 10.84 | 88 | 67320 | 15087 | 29869983 |
Ischaemic stroke | 29.38 | 10.84 | 92 | 67316 | 16183 | 29868887 |
Intentional overdose | 29.33 | 10.84 | 30 | 67378 | 41451 | 29843619 |
Oedema peripheral | 29.11 | 10.84 | 365 | 67043 | 105467 | 29779603 |
Jugular vein distension | 29.07 | 10.84 | 17 | 67391 | 523 | 29884547 |
Electrocardiogram ST segment depression | 28.98 | 10.84 | 31 | 67377 | 2331 | 29882739 |
Orthostatic hypotension | 28.31 | 10.84 | 118 | 67290 | 23861 | 29861209 |
Aortic stenosis | 28.30 | 10.84 | 40 | 67368 | 4008 | 29881062 |
Cytomegalovirus infection | 28.29 | 10.84 | 9 | 67399 | 23665 | 29861405 |
Cardiorenal syndrome | 28.28 | 10.84 | 19 | 67389 | 749 | 29884321 |
Conduction disorder | 28.27 | 10.84 | 28 | 67380 | 1923 | 29883147 |
Blood creatinine increased | 28.13 | 10.84 | 322 | 67086 | 91053 | 29794017 |
Suicidal ideation | 28.02 | 10.84 | 24 | 67384 | 36090 | 29848980 |
Depression | 27.80 | 10.84 | 107 | 67301 | 90330 | 29794740 |
Neutrophil count decreased | 27.49 | 10.84 | 33 | 67375 | 42421 | 29842649 |
Drug dependence | 27.47 | 10.84 | 7 | 67401 | 21288 | 29863782 |
Stomatitis | 27.46 | 10.84 | 26 | 67382 | 37253 | 29847817 |
Haematoma | 26.83 | 10.84 | 116 | 67292 | 23837 | 29861233 |
Congestive cardiomyopathy | 26.63 | 10.84 | 51 | 67357 | 6576 | 29878494 |
Mucosal inflammation | 26.56 | 10.84 | 18 | 67390 | 30476 | 29854594 |
Blood potassium increased | 25.98 | 10.84 | 88 | 67320 | 16125 | 29868945 |
Bundle branch block left | 25.96 | 10.84 | 44 | 67364 | 5160 | 29879910 |
Cardioactive drug level below therapeutic | 25.49 | 10.84 | 5 | 67403 | 0 | 29885070 |
International normalised ratio abnormal | 24.88 | 10.84 | 33 | 67375 | 3113 | 29881957 |
Pleural effusion | 24.62 | 10.84 | 265 | 67143 | 73801 | 29811269 |
Product use issue | 24.60 | 10.84 | 41 | 67367 | 45975 | 29839095 |
Oedema | 24.33 | 10.84 | 173 | 67235 | 42820 | 29842250 |
Fall | 24.08 | 10.84 | 557 | 66851 | 181315 | 29703755 |
Dyspnoea exertional | 23.93 | 10.84 | 149 | 67259 | 35281 | 29849789 |
Myasthenic syndrome | 23.93 | 10.84 | 13 | 67395 | 346 | 29884724 |
Peripheral embolism | 23.80 | 10.84 | 18 | 67390 | 857 | 29884213 |
Therapeutic product effect incomplete | 23.32 | 10.84 | 25 | 67383 | 33809 | 29851261 |
Diabetic ketoacidosis | 23.20 | 10.84 | 4 | 67404 | 15982 | 29869088 |
Anuria | 23.12 | 10.84 | 63 | 67345 | 10253 | 29874817 |
Dilatation atrial | 22.87 | 10.84 | 26 | 67382 | 2093 | 29882977 |
Faeces discoloured | 22.61 | 10.84 | 76 | 67332 | 13870 | 29871200 |
Malignant neoplasm progression | 22.55 | 10.84 | 85 | 67323 | 72202 | 29812868 |
Epistaxis | 22.21 | 10.84 | 199 | 67209 | 52782 | 29832288 |
Hypersensitivity | 22.21 | 10.84 | 56 | 67352 | 53972 | 29831098 |
Polymerase chain reaction | 22.15 | 10.84 | 8 | 67400 | 76 | 29884994 |
Drug reaction with eosinophilia and systemic symptoms | 22.02 | 10.84 | 19 | 67389 | 28469 | 29856601 |
Upper gastrointestinal haemorrhage | 21.92 | 10.84 | 103 | 67305 | 21925 | 29863145 |
Cardiac output decreased | 21.67 | 10.84 | 17 | 67391 | 855 | 29884215 |
Brain natriuretic peptide increased | 21.31 | 10.84 | 35 | 67373 | 4000 | 29881070 |
Benign gastrointestinal neoplasm | 21.24 | 10.84 | 9 | 67399 | 135 | 29884935 |
Lethargy | 21.20 | 10.84 | 157 | 67251 | 39362 | 29845708 |
Cardiac death | 21.17 | 10.84 | 18 | 67390 | 1015 | 29884055 |
Dilatation ventricular | 21.02 | 10.84 | 28 | 67380 | 2652 | 29882418 |
Orthopnoea | 20.84 | 10.84 | 37 | 67371 | 4503 | 29880567 |
Concomitant disease progression | 20.81 | 10.84 | 27 | 67381 | 2493 | 29882577 |
Psoriatic arthropathy | 20.68 | 10.84 | 5 | 67403 | 15756 | 29869314 |
Intentional self-injury | 20.51 | 10.84 | 3 | 67405 | 13529 | 29871541 |
Renal impairment | 20.49 | 10.84 | 284 | 67124 | 83900 | 29801170 |
Back pain | 20.41 | 10.84 | 141 | 67267 | 102455 | 29782615 |
Lip discolouration | 20.38 | 10.84 | 9 | 67399 | 150 | 29884920 |
Oesophageal achalasia | 20.37 | 10.84 | 11 | 67397 | 289 | 29884781 |
Blood pressure increased | 20.28 | 10.84 | 88 | 67320 | 71840 | 29813230 |
Drug resistance | 20.21 | 10.84 | 10 | 67398 | 20123 | 29864947 |
Pain | 20.00 | 10.84 | 271 | 67137 | 172370 | 29712700 |
Activated partial thromboplastin time prolonged | 19.78 | 10.84 | 50 | 67358 | 7778 | 29877292 |
Drug withdrawal syndrome | 19.64 | 10.84 | 10 | 67398 | 19799 | 29865271 |
Pancytopenia | 19.43 | 10.84 | 112 | 67296 | 84940 | 29800130 |
Fluid retention | 19.37 | 10.84 | 109 | 67299 | 24889 | 29860181 |
Haemorrhage intracranial | 19.36 | 10.84 | 76 | 67332 | 14956 | 29870114 |
Lymphadenopathy | 19.16 | 10.84 | 16 | 67392 | 24360 | 29860710 |
Infusion related reaction | 19.14 | 10.84 | 39 | 67369 | 40525 | 29844545 |
Muscle spasms | 19.10 | 10.84 | 78 | 67330 | 64760 | 29820310 |
Palpitations | 18.94 | 10.84 | 135 | 67273 | 33438 | 29851632 |
Creatinine renal clearance decreased | 18.69 | 10.84 | 30 | 67378 | 3363 | 29881707 |
Treatment failure | 18.44 | 10.84 | 31 | 67377 | 34648 | 29850422 |
Ventricular dysfunction | 18.28 | 10.84 | 31 | 67377 | 3636 | 29881434 |
Irritability | 18.27 | 10.84 | 15 | 67393 | 23035 | 29862035 |
Electrocardiogram repolarisation abnormality | 18.23 | 10.84 | 14 | 67394 | 682 | 29884388 |
Colitis ulcerative | 18.13 | 10.84 | 5 | 67403 | 14429 | 29870641 |
Acute myocardial infarction | 17.86 | 10.84 | 190 | 67218 | 52749 | 29832321 |
Enzyme induction | 17.74 | 10.84 | 6 | 67402 | 46 | 29885024 |
Hepatitis C | 17.70 | 10.84 | 4 | 67404 | 13201 | 29871869 |
Hyperthyroidism | 17.70 | 10.84 | 49 | 67359 | 8049 | 29877021 |
Ventricular hypertrophy | 17.69 | 10.84 | 36 | 67372 | 4851 | 29880219 |
Burning feet syndrome | 17.64 | 10.84 | 7 | 67401 | 88 | 29884982 |
Atrioventricular block second degree | 17.62 | 10.84 | 28 | 67380 | 3112 | 29881958 |
Coronary artery bypass | 17.48 | 10.84 | 37 | 67371 | 5125 | 29879945 |
Haemorrhage | 17.27 | 10.84 | 169 | 67239 | 45910 | 29839160 |
Insomnia | 17.25 | 10.84 | 131 | 67277 | 93205 | 29791865 |
Chromatopsia | 17.11 | 10.84 | 9 | 67399 | 224 | 29884846 |
Transient ischaemic attack | 17.03 | 10.84 | 106 | 67302 | 25094 | 29859976 |
Tachycardia foetal | 16.72 | 10.84 | 10 | 67398 | 321 | 29884749 |
Diverticulum intestinal haemorrhagic | 16.60 | 10.84 | 22 | 67386 | 2073 | 29882997 |
Cardiac failure acute | 16.57 | 10.84 | 52 | 67356 | 9157 | 29875913 |
Drug intolerance | 16.34 | 10.84 | 50 | 67358 | 45241 | 29839829 |
Pulmonary arterial pressure increased | 16.29 | 10.84 | 16 | 67392 | 1088 | 29883982 |
Hepatocellular injury | 16.27 | 10.84 | 20 | 67388 | 25451 | 29859619 |
Brain natriuretic peptide | 16.12 | 10.84 | 5 | 67403 | 28 | 29885042 |
Joint swelling | 16.11 | 10.84 | 53 | 67355 | 46893 | 29838177 |
Embolic stroke | 15.96 | 10.84 | 29 | 67379 | 3593 | 29881477 |
Anaphylactic reaction | 15.83 | 10.84 | 24 | 67384 | 27958 | 29857112 |
Sinusitis | 15.78 | 10.84 | 32 | 67376 | 33313 | 29851757 |
Injury | 15.69 | 10.84 | 93 | 67315 | 21638 | 29863432 |
Eosinophilia | 15.69 | 10.84 | 16 | 67392 | 22144 | 29862926 |
Hyponatraemia | 15.66 | 10.84 | 225 | 67183 | 66977 | 29818093 |
Influenza | 15.59 | 10.84 | 48 | 67360 | 43350 | 29841720 |
Peripheral coldness | 15.56 | 10.84 | 41 | 67367 | 6542 | 29878528 |
Drug-induced liver injury | 15.48 | 10.84 | 15 | 67393 | 21259 | 29863811 |
Aortic valve stenosis | 15.29 | 10.84 | 19 | 67389 | 1680 | 29883390 |
Subdural haemorrhage | 15.28 | 10.84 | 25 | 67383 | 2847 | 29882223 |
Normochromic normocytic anaemia | 15.28 | 10.84 | 30 | 67378 | 3940 | 29881130 |
Mitral valve sclerosis | 15.22 | 10.84 | 7 | 67401 | 129 | 29884941 |
Presyncope | 15.19 | 10.84 | 74 | 67334 | 15982 | 29869088 |
Congestive hepatopathy | 15.10 | 10.84 | 20 | 67388 | 1884 | 29883186 |
Pneumocystis jirovecii pneumonia | 15.05 | 10.84 | 10 | 67398 | 17110 | 29867960 |
COVID-19 | 14.98 | 10.84 | 11 | 67397 | 17867 | 29867203 |
Abnormal loss of weight | 14.96 | 10.84 | 29 | 67379 | 3773 | 29881297 |
Polypectomy | 14.89 | 10.84 | 11 | 67397 | 505 | 29884565 |
Cerebral haematoma | 14.88 | 10.84 | 32 | 67376 | 4482 | 29880588 |
Sleep disorder | 14.83 | 10.84 | 20 | 67388 | 24459 | 29860611 |
Anhedonia | 14.82 | 10.84 | 47 | 67361 | 8322 | 29876748 |
Urticaria | 14.67 | 10.84 | 68 | 67340 | 54538 | 29830532 |
Arthropathy | 14.64 | 10.84 | 15 | 67393 | 20712 | 29864358 |
Tricuspid valve sclerosis | 14.60 | 10.84 | 5 | 67403 | 40 | 29885030 |
Haematemesis | 14.56 | 10.84 | 105 | 67303 | 26098 | 29858972 |
Right atrial dilatation | 14.53 | 10.84 | 9 | 67399 | 308 | 29884762 |
Gastric mucosal lesion | 14.34 | 10.84 | 11 | 67397 | 535 | 29884535 |
Cyanosis | 14.30 | 10.84 | 59 | 67349 | 11876 | 29873194 |
Cerebral infarction | 14.27 | 10.84 | 105 | 67303 | 26268 | 29858802 |
Constipation | 14.26 | 10.84 | 174 | 67234 | 112732 | 29772338 |
Somnolence | 14.25 | 10.84 | 144 | 67264 | 96619 | 29788451 |
Palmar-plantar erythrodysaesthesia syndrome | 14.02 | 10.84 | 8 | 67400 | 14862 | 29870208 |
Tracheal injury | 13.99 | 10.84 | 4 | 67404 | 16 | 29885054 |
Withdrawal syndrome | 13.94 | 10.84 | 4 | 67404 | 11246 | 29873824 |
Aspergillus infection | 13.88 | 10.84 | 3 | 67405 | 10211 | 29874859 |
Haemothorax | 13.88 | 10.84 | 27 | 67381 | 3522 | 29881548 |
Dyspnoea paroxysmal nocturnal | 13.79 | 10.84 | 15 | 67393 | 1150 | 29883920 |
Atrial thrombosis | 13.76 | 10.84 | 19 | 67389 | 1862 | 29883208 |
Graft versus host disease | 13.76 | 10.84 | 3 | 67405 | 10147 | 29874923 |
Electrocardiogram QRS complex prolonged | 13.73 | 10.84 | 30 | 67378 | 4247 | 29880823 |
N-terminal prohormone brain natriuretic peptide increased | 13.66 | 10.84 | 16 | 67392 | 1330 | 29883740 |
Suicide attempt | 13.60 | 10.84 | 40 | 67368 | 36657 | 29848413 |
Inappropriate schedule of product administration | 13.53 | 10.84 | 45 | 67363 | 39683 | 29845387 |
Colitis | 13.41 | 10.84 | 31 | 67377 | 30789 | 29854281 |
Electrocardiogram abnormal | 13.22 | 10.84 | 36 | 67372 | 5856 | 29879214 |
Chills | 13.14 | 10.84 | 102 | 67306 | 72236 | 29812834 |
Electrocardiogram ST-T change | 13.11 | 10.84 | 11 | 67397 | 609 | 29884461 |
Synovitis | 13.04 | 10.84 | 3 | 67405 | 9780 | 29875290 |
Rectal haemorrhage | 13.02 | 10.84 | 128 | 67280 | 34811 | 29850259 |
Dystonia | 12.93 | 10.84 | 3 | 67405 | 9724 | 29875346 |
Tremor | 12.89 | 10.84 | 108 | 67300 | 75255 | 29809815 |
Generalised tonic-clonic seizure | 12.86 | 10.84 | 15 | 67393 | 19536 | 29865534 |
Infection | 12.85 | 10.84 | 113 | 67295 | 77961 | 29807109 |
Haematocrit decreased | 12.70 | 10.84 | 115 | 67293 | 30584 | 29854486 |
Angina unstable | 12.57 | 10.84 | 58 | 67350 | 12252 | 29872818 |
Osteonecrosis of jaw | 12.56 | 10.84 | 14 | 67394 | 18604 | 29866466 |
Oliguria | 12.47 | 10.84 | 41 | 67367 | 7398 | 29877672 |
Neuralgia | 12.47 | 10.84 | 4 | 67404 | 10462 | 29874608 |
Rash maculo-papular | 12.37 | 10.84 | 24 | 67384 | 25394 | 29859676 |
Hypovolaemia | 12.31 | 10.84 | 45 | 67363 | 8560 | 29876510 |
Limited symptom panic attack | 12.18 | 10.84 | 5 | 67403 | 69 | 29885001 |
Tumour lysis syndrome | 12.05 | 10.84 | 7 | 67401 | 12878 | 29872192 |
Cerebral haemorrhage | 12.02 | 10.84 | 120 | 67288 | 32767 | 29852303 |
Morning glory syndrome | 12.01 | 10.84 | 3 | 67405 | 6 | 29885064 |
Musculoskeletal pain | 12.00 | 10.84 | 33 | 67375 | 30907 | 29854163 |
Blood pressure fluctuation | 11.98 | 10.84 | 13 | 67395 | 17490 | 29867580 |
Transplant rejection | 11.92 | 10.84 | 3 | 67405 | 9203 | 29875867 |
Mania | 11.82 | 10.84 | 3 | 67405 | 9151 | 29875919 |
Cardioversion | 11.76 | 10.84 | 12 | 67396 | 854 | 29884216 |
Drug level increased | 11.65 | 10.84 | 76 | 67332 | 18278 | 29866792 |
Urine leukocyte esterase positive | 11.63 | 10.84 | 8 | 67400 | 328 | 29884742 |
Herpes zoster | 11.57 | 10.84 | 32 | 67376 | 29911 | 29855159 |
Bundle branch block | 11.50 | 10.84 | 12 | 67396 | 877 | 29884193 |
Electrocardiogram ST segment abnormal | 11.49 | 10.84 | 10 | 67398 | 582 | 29884488 |
Wrong patient received product | 11.31 | 10.84 | 17 | 67391 | 1800 | 29883270 |
Encephalopathy | 11.30 | 10.84 | 36 | 67372 | 32169 | 29852901 |
Seizure | 11.23 | 10.84 | 155 | 67253 | 98320 | 29786750 |
Pulmonary embolism | 11.20 | 10.84 | 117 | 67291 | 78018 | 29807052 |
Lymphopenia | 11.15 | 10.84 | 8 | 67400 | 13155 | 29871915 |
Erythema | 11.09 | 10.84 | 116 | 67292 | 77335 | 29807735 |
Emotional distress | 11.08 | 10.84 | 67 | 67341 | 15698 | 29869372 |
Medication error | 11.06 | 10.84 | 83 | 67325 | 20889 | 29864181 |
Pain in extremity | 11.02 | 10.84 | 178 | 67230 | 110043 | 29775027 |
Posterior reversible encephalopathy syndrome | 10.97 | 10.84 | 3 | 67405 | 8704 | 29876366 |
Aortic valve incompetence | 10.97 | 10.84 | 30 | 67378 | 4893 | 29880177 |
Tinnitus | 10.96 | 10.84 | 12 | 67396 | 16076 | 29868994 |
Haemodynamic test abnormal | 10.89 | 10.84 | 4 | 67404 | 40 | 29885030 |
Source | Code | Description |
---|---|---|
ATC | C01AA05 | CARDIOVASCULAR SYSTEM CARDIAC THERAPY CARDIAC GLYCOSIDES Digitalis glycosides |
FDA CS | M0003451 | Cardiac Glycosides |
FDA EPC | N0000175568 | Cardiac Glycoside |
CHEBI has role | CHEBI:38070 | antiarrhythmic agent |
CHEBI has role | CHEBI:38147 | cardiotonic drugs |
CHEBI has role | CHEBI:53000 | epitope function |
CHEBI has role | CHEBI:63510 | na(+)/k(+)-pump inhibitors |
MeSH PA | D000889 | Anti-Arrhythmia Agents |
MeSH PA | D002316 | Cardiotonic Agents |
MeSH PA | D002317 | Cardiovascular Agents |
MeSH PA | D004791 | Enzyme Inhibitors |
MeSH PA | D020011 | Protective Agents |
Disease | Relation | SNOMED_ID | DOID |
---|---|---|---|
Poisoning by digitalis glycoside | indication | 12876009 | |
Chronic heart failure | indication | 48447003 | |
Atrial fibrillation | indication | 49436004 | DOID:0060224 |
Senile cardiac amyloidosis | contraindication | 16573007 | |
Myocardial infarction | contraindication | 22298006 | DOID:5844 |
Sick sinus syndrome | contraindication | 36083008 | DOID:13884 |
Myxedema | contraindication | 43153006 | DOID:11634 |
Hypokalemia | contraindication | 43339004 | |
Sinus bradycardia | contraindication | 49710005 | |
Myocarditis | contraindication | 50920009 | DOID:820 |
Acute nephropathy | contraindication | 58574008 | |
Hypercalcemia | contraindication | 66931009 | DOID:12678 |
Ventricular fibrillation | contraindication | 71908006 | |
Wolff-Parkinson-White pattern | contraindication | 74390002 | DOID:384 |
Cor pulmonale | contraindication | 83291003 | DOID:8515 |
Constrictive pericarditis | contraindication | 85598007 | DOID:11481 |
Kidney disease | contraindication | 90708001 | DOID:557 |
Hypomagnesemia | contraindication | 190855004 | |
Atrioventricular block | contraindication | 233917008 | DOID:0050820 |
Idiopathic hypertrophic subaortic stenosis | contraindication | 360465008 | |
Restrictive cardiomyopathy | contraindication | 415295002 | DOID:397 |
None
None
None
Target | Class | Pharos | UniProt | Action | Type | Activity value (-log[M]) | Mechanism action | Bioact source | MoA source |
---|---|---|---|---|---|---|---|---|---|
Sodium/potassium-transporting ATPase | Transporter | INHIBITOR | IC50 | 6.40 | CHEMBL | CHEMBL | |||
Potassium voltage-gated channel subfamily H member 2 | Ion channel | IC50 | 4.14 | WOMBAT-PK | |||||
Signal transducer and activator of transcription 3 | Transcription factor | IC50 | 5.73 | CHEMBL | |||||
Nuclear receptor ROR-gamma | Nuclear hormone receptor | IC50 | 5.70 | CHEMBL | |||||
Sodium/potassium-transporting ATPase subunit alpha-1 | Transporter | IC50 | 6.30 | CHEMBL | |||||
Sodium/potassium-transporting ATPase subunit alpha-2 | Ion channel | IC50 | 5.78 | DRUG MATRIX | |||||
Nuclear receptor ROR-gamma | Unclassified | IC50 | 5.70 | CHEMBL |
ID | Source |
---|---|
4018047 | VUID |
N0000146388 | NUI |
D00298 | KEGG_DRUG |
4018047 | VANDF |
C2825111 | UMLSCUI |
CHEBI:4551 | CHEBI |
DGX | PDB_CHEM_ID |
CHEMBL1751 | ChEMBL_ID |
DB00390 | DRUGBANK_ID |
D004077 | MESH_DESCRIPTOR_UI |
3062 | PUBCHEM_CID |
4726 | IUPHAR_LIGAND_ID |
389 | INN_ID |
73K4184T59 | UNII |
3407 | RXNORM |
1413 | MMSL |
4597 | MMSL |
d00210 | MMSL |
000593 | NDDF |
387461009 | SNOMEDCT_US |
796001 | SNOMEDCT_US |
Product | Category | Ingredients | NDC | Form | Quantity | Route | Marketing | Label |
---|---|---|---|---|---|---|---|---|
Digoxin | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0054-0057 | SOLUTION | 0.05 mg | ORAL | NDA | 27 sections |
Digoxin | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0115-9811 | TABLET | 125 ug | ORAL | ANDA | 26 sections |
Digoxin | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0115-9822 | TABLET | 250 ug | ORAL | ANDA | 26 sections |
Digoxin | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0143-1240 | TABLET | 125 ug | ORAL | ANDA | 26 sections |
Digoxin | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0143-1241 | TABLET | 250 ug | ORAL | ANDA | 26 sections |
DIGITEK | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0378-6155 | TABLET | 0.13 mg | ORAL | ANDA | 26 sections |
DIGITEK | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0378-6156 | TABLET | 0.25 mg | ORAL | ANDA | 26 sections |
DIGOX | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0527-1324 | TABLET | 125 ug | ORAL | ANDA | 22 sections |
DIGOX | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0527-1325 | TABLET | 250 ug | ORAL | ANDA | 22 sections |
Digoxin | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0615-0547 | TABLET | 0.13 mg | ORAL | ANDA | 12 sections |
Digoxin | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0615-7729 | TABLET | 125 ug | ORAL | ANDA | 22 sections |
Digoxin | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0615-7730 | TABLET | 250 ug | ORAL | ANDA | 22 sections |
Digoxin | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0615-8202 | TABLET | 125 ug | ORAL | ANDA | 27 sections |
Digoxin | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0641-1410 | INJECTION | 0.25 mg | INTRAMUSCULAR | ANDA | 26 sections |
Digoxin | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0641-6184 | INJECTION | 0.25 mg | INTRAMUSCULAR | ANDA | 26 sections |
Digoxin | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0781-3059 | INJECTION, SOLUTION | 250 ug | INTRAMUSCULAR | ANDA | 26 sections |
Digoxin | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0904-5921 | TABLET | 125 ug | ORAL | ANDA | 26 sections |
Digoxin | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0904-5922 | TABLET | 250 ug | ORAL | ANDA | 26 sections |
Digoxin | HUMAN PRESCRIPTION DRUG LABEL | 1 | 16714-590 | TABLET | 125 ug | ORAL | ANDA | 25 sections |
Digoxin | HUMAN PRESCRIPTION DRUG LABEL | 1 | 16714-591 | TABLET | 250 ug | ORAL | ANDA | 25 sections |
Digoxin | HUMAN PRESCRIPTION DRUG LABEL | 1 | 17856-0057 | SOLUTION | 0.05 mg | ORAL | NDA | 25 sections |
Digoxin | HUMAN PRESCRIPTION DRUG LABEL | 1 | 21695-678 | TABLET | 0.13 mg | ORAL | ANDA | 17 sections |
LANOXIN | HUMAN PRESCRIPTION DRUG LABEL | 1 | 24987-262 | INJECTION, SOLUTION | 100 ug | INTRAMUSCULAR | NDA | 24 sections |
DIGITEK | HUMAN PRESCRIPTION DRUG LABEL | 1 | 42292-002 | TABLET | 0.25 mg | ORAL | ANDA | 26 sections |
DIGITEK | HUMAN PRESCRIPTION DRUG LABEL | 1 | 42292-003 | TABLET | 0.13 mg | ORAL | ANDA | 26 sections |
Digoxin | HUMAN PRESCRIPTION DRUG LABEL | 1 | 50090-4432 | TABLET | 125 ug | ORAL | ANDA | 28 sections |
Digoxin | HUMAN PRESCRIPTION DRUG LABEL | 1 | 50090-5276 | TABLET | 125 ug | ORAL | ANDA | 22 sections |
Digoxin | HUMAN PRESCRIPTION DRUG LABEL | 1 | 50090-5311 | TABLET | 250 ug | ORAL | ANDA | 22 sections |
Digoxin | HUMAN PRESCRIPTION DRUG LABEL | 1 | 50436-0324 | TABLET | 125 ug | ORAL | ANDA | 22 sections |
Digoxin | HUMAN PRESCRIPTION DRUG LABEL | 1 | 50564-544 | TABLET | 125 ug | ORAL | ANDA | 22 sections |