digoxin ๐Ÿถ Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
882 20830-75-5

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • digoxin
  • cardiogoxin
  • digoxine
A cardiotonic glycoside obtained mainly from Digitalis lanata; it consists of three sugars and the aglycone DIGOXIGENIN. Digoxin has positive inotropic and negative chronotropic activity. It is used to control ventricular rate in ATRIAL FIBRILLATION and in the management of congestive heart failure with atrial fibrillation. Its use in congestive heart failure and sinus rhythm is less certain. The margin between toxic and therapeutic doses is small. (From Martindale, The Extra Pharmacopoeia, 30th ed, p666)
  • Molecular weight: 780.95
  • Formula: C41H64O14
  • CLOGP: 1.42
  • LIPINSKI: 3
  • HAC: 14
  • HDO: 6
  • TPSA: 203.06
  • ALOGS: -3.79
  • ROTB: 7

  • Status: OFP

  • Legend:
    OFP - off patent
    OFM - off market
    ONP - on patent

Drug dosage:

DoseUnitRoute
0.25 mg O
0.25 mg P

ADMET properties:

PropertyValueReference
BDDCS (Biopharmaceutical Drug Disposition Classification System) 3 Benet LZ, Broccatelli F, Oprea TI
S (Water solubility) 0.99 mg/mL Benet LZ, Broccatelli F, Oprea TI
EoM (Fraction excreted unchanged in urine) 60 % Benet LZ, Broccatelli F, Oprea TI
MRTD (Maximum Recommended Therapeutic Daily Dose) 0.00 ยตM/kg/day Contrera JF, Matthews EJ, Kruhlak NL, Benz RD
BA (Bioavailability) 70 % Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H
Vd (Volume of distribution) 4.10 L/kg Lombardo F, Berellini G, Obach RS
CL (Clearance) 1.70 mL/min/kg Lombardo F, Berellini G, Obach RS
fu (Fraction unbound in plasma) 0.70 % Lombardo F, Berellini G, Obach RS
t_half (Half-life) 38 hours Lombardo F, Berellini G, Obach RS

Approvals:

DateAgencyCompanyOrphan
Oct. 24, 1975 FDA EUROHLTH INTL SARL

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Cardioactive drug level increased 1251.90 10.68 340 80886 1644 50522254
Bradycardia 1005.34 10.68 830 80396 63596 50460302
International normalised ratio increased 899.28 10.68 660 80566 42492 50481406
Atrial fibrillation 616.33 10.68 787 80439 100958 50422940
Cardiac failure congestive 607.09 10.68 712 80514 83670 50440228
Toxicity to various agents 555.29 10.68 1119 80107 211380 50312518
Drug interaction 551.42 10.68 1076 80150 198545 50325353
Cardiac failure 410.29 10.68 556 80670 75484 50448414
Drug ineffective 377.52 10.68 459 80767 818874 49705024
Hyperkalaemia 317.93 10.68 389 80837 47700 50476198
Acute kidney injury 282.93 10.68 906 80320 227152 50296746
Pulmonary hypertension 223.54 10.68 272 80954 33145 50490753
Pain 198.07 10.68 395 80831 578508 49945390
Renal failure 195.07 10.68 488 80738 106145 50417753
Right ventricular failure 193.46 10.68 178 81048 15715 50508183
Arthralgia 192.42 10.68 254 80972 438448 50085450
Bradyarrhythmia 191.42 10.68 82 81144 1808 50522090
Torsade de pointes 183.21 10.68 152 81074 11683 50512215
Off label use 182.43 10.68 301 80925 474125 50049773
Product complaint 174.88 10.68 146 81080 11320 50512578
Joint swelling 172.94 10.68 89 81137 245197 50278701
Synovitis 172.04 10.68 6 81220 123859 50400039
Rheumatoid arthritis 171.07 10.68 56 81170 202494 50321404
Pulmonary arterial hypertension 168.85 10.68 185 81041 20134 50503764
Melaena 162.59 10.68 208 81018 26656 50497242
Dyspnoea 160.40 10.68 1457 79769 546151 49977747
Systemic lupus erythematosus 159.95 10.68 19 81207 140603 50383295
Gastrointestinal haemorrhage 158.32 10.68 358 80868 72963 50450935
Ventricular tachycardia 158.17 10.68 159 81067 15662 50508236
Rash 156.79 10.68 290 80936 437181 50086717
Drug intolerance 155.17 10.68 79 81147 219025 50304873
Contraindicated product administered 153.48 10.68 27 81199 148931 50374967
Alopecia 152.83 10.68 103 81123 244944 50278954
Drug hypersensitivity 145.49 10.68 114 81112 250896 50273002
Therapeutic product effect decreased 143.84 10.68 23 81203 136027 50387871
Hand deformity 142.20 10.68 4 81222 100195 50423703
Treatment failure 141.68 10.68 25 81201 137612 50386286
Infusion related reaction 137.74 10.68 50 81176 169507 50354391
Hypotension 137.32 10.68 742 80484 234727 50289171
Glossodynia 132.95 10.68 15 81211 115554 50408344
Atrioventricular block 127.83 10.68 96 81130 6382 50517516
Arthropathy 127.52 10.68 47 81179 157859 50366039
Cardioactive drug level above therapeutic 115.20 10.68 30 81196 119 50523779
Atrioventricular block first degree 113.78 10.68 88 81138 6113 50517785
Upper gastrointestinal haemorrhage 112.89 10.68 134 81092 15901 50507997
Syncope 102.70 10.68 381 80845 102621 50421277
Wound 100.96 10.68 23 81203 105771 50418127
Subdural haematoma 99.18 10.68 113 81113 12834 50511064
Arrhythmia 98.92 10.68 185 81041 32947 50490951
Hypersensitivity 98.82 10.68 120 81106 215041 50308857
Hypervolaemia 96.44 10.68 158 81068 25341 50498557
Oedema peripheral 96.20 10.68 504 80722 157457 50366441
Atrioventricular block complete 95.64 10.68 85 81141 7170 50516728
Cardiac arrest 95.02 10.68 323 80903 83328 50440570
Myocardial infarction 94.40 10.68 336 80890 88691 50435207
Sinusitis 94.35 10.68 81 81145 170477 50353421
Musculoskeletal stiffness 92.88 10.68 45 81181 128436 50395462
Pericarditis 91.03 10.68 10 81216 78679 50445219
Cerebrovascular accident 90.88 10.68 346 80880 94334 50429564
Nodal rhythm 89.67 10.68 46 81180 1541 50522357
Sinus bradycardia 87.62 10.68 107 81119 13076 50510822
International normalised ratio abnormal 84.01 10.68 54 81172 2789 50521109
Lower gastrointestinal haemorrhage 81.68 10.68 76 81150 6803 50517095
Product use issue 81.43 10.68 72 81154 149403 50374495
Anaemia 81.39 10.68 687 80539 251769 50272129
Cardioactive drug level decreased 81.10 10.68 20 81206 60 50523838
Pruritus 80.78 10.68 213 81013 283355 50240543
Asthenia 79.69 10.68 822 80404 318220 50205678
Stomatitis 78.74 10.68 32 81194 101312 50422586
Injection site pain 78.56 10.68 40 81186 110984 50412914
Rectal haemorrhage 77.38 10.68 183 81043 38375 50485523
Nasopharyngitis 77.08 10.68 119 81107 192808 50331090
Nodal arrhythmia 76.58 10.68 37 81189 1087 50522811
Swelling 76.40 10.68 128 81098 200744 50323154
International normalised ratio decreased 76.40 10.68 59 81167 4089 50519809
Hypoxia 75.23 10.68 216 81010 50907 50472991
Presyncope 74.59 10.68 137 81089 24061 50499837
Ventricular fibrillation 73.93 10.68 88 81138 10471 50513427
Hepatic enzyme increased 73.84 10.68 67 81159 137313 50386585
Dehydration 72.82 10.68 456 80770 151993 50371905
Fluid retention 72.60 10.68 212 81014 50437 50473461
Cerebral haemorrhage 72.12 10.68 144 81082 26908 50496990
Drug level increased 70.98 10.68 118 81108 19150 50504748
Abdominal discomfort 70.60 10.68 168 81058 231473 50292425
Hyponatraemia 70.08 10.68 323 80903 95816 50428082
Discomfort 68.22 10.68 45 81181 108335 50415563
Injection site erythema 68.15 10.68 18 81208 74918 50448980
Atrioventricular block second degree 67.77 10.68 52 81174 3569 50520329
Rheumatoid factor positive 67.21 10.68 3 81223 49856 50474042
Drug abuse 65.80 10.68 9 81217 59837 50464061
Therapeutic product effect incomplete 64.70 10.68 33 81193 91482 50432416
Ischaemic stroke 64.65 10.68 102 81124 15846 50508052
Haemorrhage intracranial 64.38 10.68 89 81137 12285 50511613
Tachyarrhythmia 64.10 10.68 53 81173 4052 50519846
Intentional product use issue 63.58 10.68 22 81204 76896 50447002
Cardiomegaly 63.28 10.68 101 81125 15844 50508054
Dizziness 62.72 10.68 839 80387 345530 50178368
Prothrombin time prolonged 62.44 10.68 74 81152 8764 50515134
Orthopnoea 62.11 10.68 60 81166 5629 50518269
Electrocardiogram ST segment depression 61.18 10.68 43 81183 2577 50521321
Haematoma 60.34 10.68 144 81082 30366 50493532
Blood creatinine increased 60.09 10.68 262 80964 75898 50448000
Febrile neutropenia 59.53 10.68 42 81184 97625 50426273
Hypoglycaemia 58.29 10.68 204 81022 53377 50470521
Helicobacter infection 58.29 10.68 6 81220 49696 50474202
Atrial flutter 58.03 10.68 71 81155 8692 50515206
Duodenal ulcer perforation 57.61 10.68 4 81222 45607 50478291
Blood urea increased 57.50 10.68 121 81105 23464 50500434
Sinus node dysfunction 57.50 10.68 49 81177 3906 50519992
Overdose 57.11 10.68 313 80913 99414 50424484
Completed suicide 56.93 10.68 77 81149 131812 50392086
Injection site reaction 56.26 10.68 7 81219 50025 50473873
Abdominal wall haematoma 55.37 10.68 41 81185 2667 50521231
Paraesthesia 55.21 10.68 67 81159 120176 50403722
Death 53.94 10.68 776 80450 324603 50199295
Pleural effusion 53.79 10.68 266 80960 81188 50442710
Maternal exposure during pregnancy 52.63 10.68 111 81115 159667 50364231
Ventricular arrhythmia 52.25 10.68 43 81183 3266 50520632
Tricuspid valve incompetence 52.21 10.68 82 81144 12688 50511210
Confusional state 52.13 10.68 491 80735 185437 50338461
Fibromyalgia 51.30 10.68 6 81220 44972 50478926
Decreased appetite 51.16 10.68 520 80706 200403 50323495
Renal injury 51.03 10.68 66 81160 8545 50515353
Activated partial thromboplastin time prolonged 50.95 10.68 57 81169 6345 50517553
Electrocardiogram QT prolonged 50.89 10.68 191 81035 51695 50472203
Infection 50.65 10.68 128 81098 172826 50351072
Psoriasis 50.10 10.68 24 81202 68976 50454922
Dyspnoea exertional 49.76 10.68 188 81038 51045 50472853
Ventricular extrasystoles 47.90 10.68 71 81155 10445 50513453
Ejection fraction decreased 47.47 10.68 97 81129 18423 50505475
Irritable bowel syndrome 47.45 10.68 12 81214 51429 50472469
Psoriatic arthropathy 47.38 10.68 9 81217 47023 50476875
Injection site pruritus 47.07 10.68 5 81221 40406 50483492
Blood potassium increased 47.00 10.68 90 81136 16308 50507590
Supraventricular tachycardia 46.62 10.68 78 81148 12723 50511175
Mitral valve incompetence 45.37 10.68 92 81134 17379 50506519
Neutropenia 45.29 10.68 107 81119 147858 50376040
Urticaria 45.23 10.68 87 81139 129474 50394424
Atrial tachycardia 45.21 10.68 33 81193 2099 50521799
Epistaxis 45.21 10.68 213 81013 63741 50460157
Cardiogenic shock 45.18 10.68 86 81140 15513 50508385
Impaired healing 43.87 10.68 29 81197 69757 50454141
Fatigue 43.84 10.68 837 80389 706764 49817134
Suicidal ideation 43.81 10.68 17 81209 55368 50468530
Multiple sclerosis relapse 43.75 10.68 8 81218 42956 50480942
Bundle branch block right 43.36 10.68 45 81181 4600 50519298
Drug therapeutic incompatibility 42.78 10.68 11 81215 41 50523857
Coagulopathy 42.51 10.68 91 81135 17853 50506045
Oedema 42.01 10.68 223 81003 69958 50453940
Cardiac failure chronic 41.60 10.68 39 81187 3524 50520374
Respiratory failure 41.18 10.68 269 80957 90912 50432986
Multiple organ dysfunction syndrome 41.10 10.68 175 81051 50162 50473736
Heart rate irregular 40.05 10.68 93 81133 19267 50504631
Injection site swelling 40.00 10.68 9 81217 41764 50482134
Arthritis 39.09 10.68 49 81177 86672 50437226
Chest pain 39.06 10.68 445 80781 176437 50347461
Migraine 38.92 10.68 38 81188 75242 50448656
Fall 38.61 10.68 753 80473 334179 50189719
Electrocardiogram abnormal 38.52 10.68 54 81172 7551 50516347
Embolic stroke 38.51 10.68 37 81189 3447 50520451
Pulmonary oedema 38.32 10.68 168 81058 48770 50475128
Alveolitis 38.08 10.68 32 81194 2502 50521396
Heart rate decreased 38.01 10.68 137 81089 36360 50487538
Leukopenia 37.39 10.68 32 81194 67496 50456402
Neuropathy peripheral 37.35 10.68 61 81165 96696 50427202
Mobility decreased 37.27 10.68 44 81182 79904 50443994
Electrocardiogram QT shortened 36.92 10.68 12 81214 117 50523781
Palpitations 36.30 10.68 268 80958 94238 50429660
Gastrointestinal disorder 36.04 10.68 60 81166 94396 50429502
Hypocoagulable state 35.89 10.68 21 81205 915 50522983
Loss of consciousness 35.68 10.68 288 80938 104065 50419833
White blood cell count decreased 35.24 10.68 85 81141 116637 50407261
Hypoaesthesia 35.10 10.68 97 81129 127160 50396738
Transfusion 34.76 10.68 69 81157 12836 50511062
Xanthopsia 34.10 10.68 12 81214 152 50523746
Renal impairment 34.03 10.68 223 81003 75438 50448460
Atrioventricular dissociation 33.89 10.68 13 81213 213 50523685
Cardiac failure acute 33.76 10.68 53 81173 8197 50515701
Electrocardiogram ST segment abnormal 33.74 10.68 20 81206 893 50523005
Cardioactive drug level below therapeutic 33.73 10.68 7 81219 6 50523892
Product use in unapproved indication 33.67 10.68 86 81140 115733 50408165
Shock haemorrhagic 33.31 10.68 53 81173 8291 50515607
Calcium deficiency 33.00 10.68 20 81206 930 50522968
Bundle branch block left 32.69 10.68 45 81181 6185 50517713
Pulmonary arterial pressure increased 32.27 10.68 33 81193 3315 50520583
Brain natriuretic peptide increased 32.14 10.68 38 81188 4489 50519409
Asthma 32.04 10.68 59 81167 89278 50434620
Insomnia 31.98 10.68 158 81068 174707 50349191
Knee arthroplasty 31.85 10.68 9 81217 35837 50488061
Hyperthyroidism 31.48 10.68 64 81162 12111 50511787
Medication error 31.41 10.68 128 81098 35976 50487922
Cardiomyopathy 31.29 10.68 74 81152 15512 50508386
Peripheral swelling 31.18 10.68 198 81028 205738 50318160
Toxic epidermal necrolysis 31.16 10.68 89 81137 20903 50502995
Cardiac disorder 30.99 10.68 144 81082 42835 50481063
Cor pulmonale 30.80 10.68 25 81201 1862 50522036
Coronary artery disease 30.46 10.68 111 81115 29615 50494283
Blister 30.12 10.68 57 81169 85361 50438537
Left ventricular failure 30.09 10.68 38 81188 4803 50519095
Urine output decreased 29.62 10.68 57 81169 10364 50513534
Sleep disorder 29.51 10.68 29 81197 57254 50466644
Coagulation time prolonged 29.22 10.68 20 81206 1148 50522750
Myocardial ischaemia 28.79 10.68 60 81166 11553 50512345
Disorientation 28.68 10.68 123 81103 35361 50488537
Haemoglobin decreased 28.49 10.68 321 80905 126895 50397003
Subarachnoid haemorrhage 28.28 10.68 57 81169 10719 50513179
Headache 27.74 10.68 611 80615 505924 50017974
Accidental overdose 27.25 10.68 81 81145 19452 50504446
Metabolic acidosis 27.20 10.68 129 81097 38696 50485202
Pulse absent 27.18 10.68 36 81190 4770 50519128
Pyrexia 26.84 10.68 439 80787 379764 50144134
Intentional self-injury 26.56 10.68 3 81223 23109 50500789
Cardiac pacemaker insertion 26.49 10.68 31 81195 3622 50520276
Back pain 26.38 10.68 226 81000 219804 50304094
Hip arthroplasty 26.38 10.68 8 81218 30421 50493477
Blood cholesterol increased 26.15 10.68 30 81196 55185 50468713
Haematuria 25.70 10.68 95 81131 25518 50498380
Oropharyngeal pain 25.64 10.68 54 81172 77747 50446151
Ill-defined disorder 25.56 10.68 30 81196 54624 50469274
Lethargy 25.54 10.68 151 81075 49281 50474617
Haematemesis 25.49 10.68 100 81126 27625 50496273
Unevaluable event 25.29 10.68 143 81083 45923 50477975
Herpes zoster 25.16 10.68 47 81179 70739 50453159
Acute respiratory failure 25.01 10.68 102 81124 28680 50495218
Extrasystoles 24.99 10.68 34 81192 4621 50519277
Product dose omission issue 24.73 10.68 183 81043 183655 50340243
Depression 24.55 10.68 160 81066 165263 50358635
Drug monitoring procedure not performed 24.53 10.68 13 81213 466 50523432
Mitral valve stenosis 24.51 10.68 17 81209 997 50522901
Electrocardiogram QRS complex prolonged 24.22 10.68 36 81190 5308 50518590
Neutrophil count decreased 24.05 10.68 23 81203 46003 50477895
Oxygen consumption increased 23.98 10.68 29 81197 3507 50520391
Fear 23.89 10.68 64 81162 14485 50509413
Musculoskeletal pain 23.86 10.68 50 81176 72127 50451771
Stupor 23.67 10.68 29 81197 3554 50520344
Sopor 23.64 10.68 78 81148 19801 50504097
Erythrodermic psoriasis 23.59 10.68 16 81210 905 50522993
Blood pressure decreased 23.46 10.68 162 81064 55747 50468151
Transient ischaemic attack 23.28 10.68 108 81118 32102 50491796
Cerebral infarction 23.26 10.68 82 81144 21522 50502376
Drug level above therapeutic 23.15 10.68 30 81196 3890 50520008
Haemorrhage 23.11 10.68 156 81070 53285 50470613
Superinfection 23.04 10.68 22 81204 2034 50521864
Prothrombin time shortened 22.91 10.68 20 81206 1647 50522251
Catheter management 22.85 10.68 25 81201 2714 50521184
Chromatopsia 22.83 10.68 12 81214 423 50523475
Osteoporosis 22.79 10.68 23 81203 44856 50479042
Loss of personal independence in daily activities 22.76 10.68 49 81177 70001 50453897
Malignant neoplasm progression 22.68 10.68 47 81179 68077 50455821
Ischaemic cardiomyopathy 22.67 10.68 23 81203 2289 50521609
Pyroglutamic acidosis 22.62 10.68 12 81214 431 50523467
Hypochromic anaemia 22.61 10.68 20 81206 1676 50522222
Retroperitoneal haemorrhage 22.50 10.68 24 81202 2532 50521366
Occult blood positive 22.34 10.68 27 81199 3264 50520634
Oliguria 22.21 10.68 44 81182 8172 50515726
Muscle spasms 21.50 10.68 116 81110 125437 50398461
Splenic injury 21.45 10.68 9 81217 188 50523710
Chronic obstructive pulmonary disease 21.35 10.68 153 81073 53282 50470616
Joint stiffness 21.30 10.68 11 81215 30297 50493601
Congestive hepatopathy 21.22 10.68 23 81203 2471 50521427
Dilatation atrial 21.20 10.68 20 81206 1821 50522077
Pulmonary congestion 21.05 10.68 63 81163 15184 50508714
Therapeutic response decreased 20.95 10.68 27 81199 47204 50476694
Dyschromatopsia 20.95 10.68 11 81215 387 50523511
Vomiting 20.84 10.68 921 80305 459837 50064061
Dilatation ventricular 20.77 10.68 22 81204 2303 50521595
Aortic valve calcification 20.71 10.68 11 81215 396 50523502
Potentiating drug interaction 20.68 10.68 28 81198 3788 50520110
Hypertension 20.64 10.68 228 80998 210975 50312923
Central nervous system injury 20.59 10.68 8 81218 136 50523762
Lung transplant 20.53 10.68 24 81202 2801 50521097
Weight increased 20.51 10.68 216 81010 201675 50322223
Cardiac murmur 20.36 10.68 50 81176 10734 50513164
Left atrial dilatation 20.30 10.68 19 81207 1713 50522185
Pain in extremity 20.26 10.68 312 80914 272553 50251345
Hypovolaemia 20.16 10.68 46 81180 9419 50514479
Device related infection 20.05 10.68 76 81150 20659 50503239
Kussmaul respiration 19.96 10.68 9 81217 225 50523673
Ventricular hypertrophy 19.61 10.68 25 81201 3190 50520708
Intentional product misuse 19.43 10.68 28 81198 46706 50477192
Haemoptysis 19.41 10.68 87 81139 25486 50498412
Choroidal haemorrhage 19.40 10.68 6 81220 49 50523849
Transplant evaluation 19.35 10.68 15 81211 1045 50522853
Blood bilirubin increased 19.30 10.68 102 81124 31936 50491962
Hypokalaemia 19.22 10.68 221 81005 87771 50436127
Osteoarthritis 19.12 10.68 52 81174 68554 50455344
Left ventricular dysfunction 19.08 10.68 48 81178 10458 50513440
Red blood cell sedimentation rate increased 18.79 10.68 12 81214 29404 50494494
Foot deformity 18.67 10.68 4 81222 19206 50504692
Conduction disorder 18.60 10.68 16 81210 1292 50522606
Supraventricular extrasystoles 18.50 10.68 27 81199 3917 50519981
Iron deficiency anaemia 18.22 10.68 64 81162 16770 50507128
Inappropriate schedule of product administration 18.16 10.68 57 81169 71774 50452124
Electrocardiogram PR prolongation 18.14 10.68 12 81214 651 50523247
Dialysis 18.07 10.68 44 81182 9394 50514504
Anticoagulation drug level above therapeutic 18.03 10.68 15 81211 1157 50522741
Exposure during pregnancy 17.97 10.68 117 81109 120898 50403000
Lactic acidosis 17.95 10.68 103 81123 33252 50490646
Lymphocyte count decreased 17.83 10.68 10 81216 26297 50497601
Suicide attempt 17.81 10.68 35 81191 51697 50472201
Electrocardiogram repolarisation abnormality 17.72 10.68 15 81211 1185 50522713
Ascites 17.54 10.68 108 81118 35753 50488145
Drug dependence 17.48 10.68 5 81221 19754 50504144
Blood pressure fluctuation 17.47 10.68 19 81207 35804 50488094
COVID-19 17.46 10.68 30 81196 46632 50477266
Delirium 17.43 10.68 113 81113 38079 50485819
Obesity 17.35 10.68 3 81223 16772 50507126
Faeces discoloured 17.19 10.68 61 81165 16063 50507835
Brain stem haemorrhage 17.09 10.68 12 81214 718 50523180
Hypochromasia 17.02 10.68 9 81217 321 50523577
Hypomagnesaemia 17.00 10.68 78 81148 23078 50500820
Ventricular dysfunction 16.97 10.68 21 81205 2600 50521298
Ecchymosis 16.96 10.68 45 81181 10124 50513774
Prerenal failure 16.78 10.68 16 81210 1477 50522421
Anhedonia 16.76 10.68 43 81183 9481 50514417
Hypoglycaemic seizure 16.70 10.68 10 81216 455 50523443
Cyanosis 16.67 10.68 58 81168 15126 50508772
Anaphylactic reaction 16.59 10.68 39 81187 54016 50469882
Subcutaneous haematoma 16.58 10.68 16 81210 1499 50522399
Pain in jaw 16.51 10.68 112 81114 38316 50485582
Blood alkaline phosphatase increased 16.50 10.68 110 81116 37416 50486482
Electrocardiogram R on T phenomenon 16.48 10.68 4 81222 11 50523887
Rheumatic heart disease 16.48 10.68 4 81222 11 50523887
Cardiopulmonary bypass 16.31 10.68 3 81223 0 50523898
Respiratory distress 16.31 10.68 94 81132 30395 50493503
Chorea 16.29 10.68 15 81211 1325 50522573
Intentional overdose 16.23 10.68 49 81177 62455 50461443
Acute myocardial infarction 16.15 10.68 91 81135 29182 50494716
Tremor 16.11 10.68 113 81113 114790 50409108
Hallucination 16.06 10.68 129 81097 46528 50477370
Right ventricular systolic pressure increased 15.81 10.68 10 81216 502 50523396
Mitral valve disease 15.77 10.68 18 81208 2048 50521850
Lower respiratory tract infection 15.72 10.68 89 81137 95112 50428786
Rhythm idioventricular 15.72 10.68 7 81219 170 50523728
Dermatitis exfoliative 15.70 10.68 29 81197 5113 50518785
Wrong technique in product usage process 15.53 10.68 42 81184 55468 50468430
Depressed level of consciousness 15.43 10.68 139 81087 51814 50472084
Walking distance test abnormal 15.36 10.68 10 81216 528 50523370
Blood culture positive 15.35 10.68 26 81200 4282 50519616
Coronary arterial stent insertion 15.31 10.68 20 81206 2614 50521284
Neuralgia 15.27 10.68 8 81218 21855 50502043
Hyponatraemic syndrome 15.26 10.68 10 81216 534 50523364
Pregnancy 15.20 10.68 15 81211 29562 50494336
Basal ganglia haemorrhage 15.16 10.68 10 81216 540 50523358
Anuria 15.09 10.68 46 81180 11198 50512700
Abdominal tenderness 15.09 10.68 35 81191 7245 50516653
Haemodialysis 14.97 10.68 38 81188 8324 50515574
C-reactive protein increased 14.61 10.68 56 81170 66418 50457480
Blood loss anaemia 14.59 10.68 37 81189 8102 50515796
Aortic valve incompetence 14.41 10.68 29 81197 5447 50518451
Cholecystitis 14.38 10.68 52 81174 13819 50510079
Dizziness postural 14.37 10.68 31 81195 6114 50517784
Pneumocystis jirovecii pneumonia 14.36 10.68 3 81223 14660 50509238
Exercise tolerance decreased 14.27 10.68 27 81199 4847 50519051
Cardioversion 14.27 10.68 13 81213 1132 50522766
Electrocardiogram change 14.10 10.68 10 81216 608 50523290
Chills 14.09 10.68 94 81132 96593 50427305
Hypoglycaemic coma 14.01 10.68 18 81208 2315 50521583
Hypersensitivity vasculitis 14.00 10.68 24 81202 3991 50519907
Irritability 13.95 10.68 15 81211 28411 50495487
Orthostatic hypotension 13.93 10.68 88 81138 29393 50494505
Type 2 diabetes mellitus 13.90 10.68 21 81205 34354 50489544
Oxygen saturation decreased 13.84 10.68 179 81047 73069 50450829
Injection site mass 13.81 10.68 4 81222 15676 50508222
Ventricular asystole 13.63 10.68 5 81221 72 50523826
Colitis ulcerative 13.61 10.68 5 81221 16849 50507049
Depressed mood 13.55 10.68 21 81205 34002 50489896
Right ventricular hypertrophy 13.48 10.68 10 81216 652 50523246
Fungal infection 13.42 10.68 17 81209 29948 50493950
Cytomegalovirus infection 13.42 10.68 6 81220 17956 50505942
Multi-organ disorder 13.27 10.68 13 81213 1240 50522658
Aortic stenosis 13.24 10.68 24 81202 4170 50519728
Atrial thrombosis 13.23 10.68 14 81212 1463 50522435
Constipation 13.21 10.68 214 81012 185494 50338404
Illness 13.13 10.68 12 81214 24528 50499370
Catheter site erythema 12.93 10.68 23 81203 3939 50519959
Mental status changes 12.87 10.68 101 81125 36171 50487727
Anxiety 12.85 10.68 204 81022 177402 50346496
Body temperature increased 12.81 10.68 19 81207 31322 50492576
Head injury 12.81 10.68 74 81152 23946 50499952
Haematocrit decreased 12.75 10.68 98 81128 34878 50489020
Azotaemia 12.74 10.68 23 81203 3985 50519913
Blood pressure immeasurable 12.65 10.68 12 81214 1100 50522798
Rales 12.63 10.68 40 81186 9938 50513960
Concomitant disease progression 12.63 10.68 16 81210 2029 50521869
Paracentesis 12.61 10.68 11 81215 905 50522993
Hereditary haemorrhagic telangiectasia 12.59 10.68 4 81222 36 50523862
Neoplasm progression 12.59 10.68 17 81209 29140 50494758
Cardio-respiratory arrest 12.51 10.68 137 81089 53755 50470143
Protein total 12.50 10.68 4 81222 37 50523861
Blood pressure increased 12.49 10.68 145 81081 132987 50390911
Aspartate aminotransferase increased 12.46 10.68 185 81041 77813 50446085
Cardiac valve disease 12.38 10.68 22 81204 3764 50520134
Cardiorenal syndrome 12.36 10.68 9 81217 570 50523328
Haemarthrosis 12.34 10.68 19 81207 2889 50521009
Anisocytosis 12.34 10.68 9 81217 572 50523326
Catheter site rash 12.32 10.68 10 81216 745 50523153
Pneumonia 12.28 10.68 733 80493 377668 50146230
Bone pain 12.28 10.68 37 81189 47192 50476706
Blood creatinine 12.26 10.68 5 81221 97 50523801
C-reactive protein abnormal 12.23 10.68 16 81210 27793 50496105
Right ventricular dilatation 12.20 10.68 11 81215 945 50522953
Panic attack 12.20 10.68 8 81218 19334 50504564
Hemiparesis 12.19 10.68 64 81162 19984 50503914
Paralysis 12.15 10.68 36 81190 8628 50515270
Intervertebral disc protrusion 12.12 10.68 9 81217 20384 50503514
Spontaneous haematoma 11.96 10.68 10 81216 776 50523122
Duodenal ulcer haemorrhage 11.90 10.68 16 81210 2150 50521748
Liver function test abnormal 11.85 10.68 116 81110 44223 50479675
Diabetic ketoacidosis 11.82 10.68 7 81219 17865 50506033
Palmar-plantar erythrodysaesthesia syndrome 11.77 10.68 9 81217 20089 50503809
Cellulitis 11.73 10.68 169 81057 70629 50453269
Serratia infection 11.70 10.68 10 81216 800 50523098
Dry eye 11.68 10.68 21 81205 32074 50491824
Catheter site infection 11.64 10.68 23 81203 4263 50519635
Eosinophilic granulomatosis with polyangiitis 11.61 10.68 15 81211 1940 50521958
Staphylococcal sepsis 11.60 10.68 31 81195 7005 50516893
Heart sounds abnormal 11.56 10.68 9 81217 631 50523267
Angina unstable 11.52 10.68 30 81196 6676 50517222
Labelled drug-drug interaction medication error 11.48 10.68 40 81186 10437 50513461
Venous haemorrhage 11.48 10.68 6 81220 209 50523689
Respiratory acidosis 11.43 10.68 28 81198 6000 50517898
Heart valve replacement 11.42 10.68 8 81218 477 50523421
Catheter site pruritus 11.41 10.68 15 81211 1972 50521926
Pharyngitis 11.37 10.68 7 81219 17496 50506402
Ear infection 11.36 10.68 15 81211 25955 50497943
Sudden death 11.34 10.68 36 81190 8955 50514943
No adverse event 11.32 10.68 23 81203 33555 50490343
Bullous haemorrhagic dermatosis 11.27 10.68 4 81222 52 50523846
Leg amputation 11.26 10.68 15 81211 1998 50521900
Acne 11.19 10.68 9 81217 19586 50504312
Blood sodium decreased 11.18 10.68 65 81161 21082 50502816
Injection site rash 11.18 10.68 6 81220 16171 50507727
Adams-Stokes syndrome 11.14 10.68 4 81222 54 50523844
Flat anterior chamber of eye 11.00 10.68 4 81222 56 50523842
Immunodeficiency 11.00 10.68 5 81221 14823 50509075
Muscle spasticity 10.99 10.68 7 81219 17177 50506721
Acute pulmonary oedema 10.97 10.68 31 81195 7236 50516662
Bundle branch block bilateral 10.96 10.68 3 81223 15 50523883
Delusion of replacement 10.96 10.68 3 81223 15 50523883
Cerebellar haematoma 10.95 10.68 7 81219 358 50523540
Tachycardia foetal 10.91 10.68 5 81221 130 50523768
Prothrombin level increased 10.91 10.68 6 81220 232 50523666
Ventricular failure 10.90 10.68 7 81219 361 50523537
Hyperchloraemia 10.84 10.68 9 81217 692 50523206
Sciatica 10.81 10.68 11 81215 21371 50502527
Cardiac output decreased 10.79 10.68 10 81216 890 50523008
Muscle haemorrhage 10.74 10.68 18 81208 2940 50520958
Basal cell carcinoma 10.72 10.68 13 81213 23343 50500555
Neutrophilia 10.71 10.68 20 81206 3555 50520343

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Cardioactive drug level increased 813.04 10.83 254 68998 1399 29503876
Bradycardia 646.86 10.83 782 68470 64847 29440428
Cardiac failure congestive 596.60 10.83 812 68440 75769 29429506
International normalised ratio increased 554.26 10.83 598 68654 43774 29461501
Atrial fibrillation 411.22 10.83 819 68433 104827 29400448
Ventricular tachycardia 245.06 10.83 283 68969 22291 29482984
Cardiac failure 208.27 10.83 526 68726 78761 29426514
Off label use 204.30 10.83 243 69009 300557 29204718
Hyperkalaemia 195.48 10.83 439 68813 60953 29444322
Toxicity to various agents 161.59 10.83 818 68434 172843 29332432
Product complaint 160.41 10.83 119 69133 5286 29499989
Drug abuse 150.98 10.83 9 69243 79874 29425401
Gastrointestinal haemorrhage 130.22 10.83 446 68806 79087 29426188
Drug ineffective 129.15 10.83 429 68823 362741 29142534
Drug interaction 117.91 10.83 828 68424 196557 29308718
Venous pressure jugular increased 110.55 10.83 47 69205 682 29504593
Hypotension 108.38 10.83 802 68450 193552 29311723
Myocardial infarction 99.18 10.83 515 68737 109781 29395494
Cardiac murmur 94.68 10.83 96 69156 6517 29498758
Acute kidney injury 91.74 10.83 986 68266 264281 29240994
Cardiac arrest 91.50 10.83 420 68832 85171 29420104
Melaena 90.38 10.83 215 69037 30961 29474314
Dyspnoea 89.01 10.83 1160 68092 325572 29179703
Cardioactive drug level above therapeutic 81.99 10.83 21 69231 46 29505229
Febrile neutropenia 78.76 10.83 88 69164 112152 29393123
Right ventricular failure 77.44 10.83 94 69158 7796 29497479
Ischaemic cardiomyopathy 77.37 10.83 80 69172 5558 29499717
Atrial flutter 75.85 10.83 125 69127 13769 29491506
Neutropenia 73.52 10.83 122 69130 131589 29373686
Nodal rhythm 70.69 10.83 42 69210 1278 29503997
Arrhythmia 70.15 10.83 196 69056 31117 29474158
Dizziness 67.72 10.83 710 68542 188974 29316301
Ventricular fibrillation 66.50 10.83 127 69125 15706 29489569
Ventricular extrasystoles 65.74 10.83 101 69151 10481 29494794
Product use in unapproved indication 64.41 10.83 65 69187 86810 29418465
Pulmonary hypertension 62.43 10.83 136 69116 18472 29486803
Bradyarrhythmia 61.82 10.83 45 69207 1940 29503335
Cardioactive drug level decreased 61.37 10.83 17 69235 56 29505219
Product dose omission issue 58.82 10.83 84 69168 96299 29408976
Prothrombin time prolonged 53.05 10.83 83 69169 8749 29496526
Tricuspid valve incompetence 51.98 10.83 80 69172 8314 29496961
Coronary artery disease 51.04 10.83 222 69030 43968 29461307
Cerebrovascular accident 50.72 10.83 331 68921 76580 29428695
Pulmonary arterial hypertension 50.41 10.83 74 69178 7375 29497900
Renal failure 50.09 10.83 460 68792 118139 29387136
Atrioventricular block 49.64 10.83 71 69181 6911 29498364
International normalised ratio decreased 49.64 10.83 55 69197 4135 29501140
Arthralgia 49.29 10.83 165 69087 139452 29365823
Torsade de pointes 49.22 10.83 69 69183 6592 29498683
Xanthopsia 49.08 10.83 17 69235 135 29505140
Mitral valve incompetence 49.04 10.83 101 69151 13192 29492083
Cardiomegaly 48.87 10.83 103 69149 13673 29491602
Atrioventricular block complete 47.72 10.83 75 69177 7936 29497339
Intentional product use issue 47.47 10.83 20 69232 42478 29462797
Confusional state 46.18 10.83 480 68772 127397 29377878
Left ventricular dysfunction 45.80 10.83 78 69174 8824 29496451
Rash 44.24 10.83 262 68990 189557 29315718
Syncope 44.16 10.83 334 68918 81037 29424238
Subdural haematoma 43.85 10.83 117 69135 18076 29487199
Conduction disorder 42.63 10.83 35 69217 1805 29503470
Drug hypersensitivity 42.33 10.83 59 69193 68347 29436928
Blood urea increased 41.92 10.83 153 69099 27959 29477316
Cardiomyopathy 41.78 10.83 101 69151 14686 29490589
Left ventricular failure 41.75 10.83 53 69199 4600 29500675
Sinus node dysfunction 40.80 10.83 47 69205 3687 29501588
Chronic obstructive pulmonary disease 40.79 10.83 197 69055 40758 29464517
Congestive cardiomyopathy 40.79 10.83 63 69189 6567 29498708
Atrioventricular block first degree 40.65 10.83 56 69196 5263 29500012
Cardiac failure chronic 40.55 10.83 62 69190 6405 29498870
Pyrexia 40.40 10.83 455 68797 287167 29218108
Asthenia 39.70 10.83 716 68536 214534 29290741
Heart rate irregular 39.67 10.83 92 69160 13025 29492250
Pruritus 38.60 10.83 142 69110 116707 29388568
Injection site pain 38.33 10.83 14 69238 32432 29472843
Haematuria 38.14 10.83 204 69048 43935 29461340
Nodal arrhythmia 37.20 10.83 23 69229 753 29504522
Intentional product misuse 36.08 10.83 18 69234 34643 29470632
Blood lactic acid 35.56 10.83 17 69235 329 29504946
Leukopenia 34.76 10.83 47 69205 55156 29450119
Headache 34.55 10.83 252 69000 173755 29331520
Ventricular arrhythmia 34.48 10.83 48 69204 4556 29500719
Blood creatinine increased 34.35 10.83 327 68925 84775 29420500
Neuropathy peripheral 34.10 10.83 72 69180 70955 29434320
Supraventricular tachycardia 34.02 10.83 73 69179 9811 29495464
Completed suicide 33.67 10.83 104 69148 90142 29415133
Orthostatic hypotension 33.60 10.83 123 69129 22506 29482769
White blood cell count decreased 33.32 10.83 93 69159 83269 29422006
Atrial tachycardia 33.07 10.83 31 69221 1910 29503365
Aortic stenosis 32.82 10.83 43 69209 3851 29501424
Nasopharyngitis 32.57 10.83 56 69196 59609 29445666
Cardiogenic shock 32.55 10.83 109 69143 19081 29486194
Oedema peripheral 32.43 10.83 378 68874 103179 29402096
Product use issue 32.19 10.83 44 69208 51400 29453875
Rheumatoid arthritis 31.55 10.83 18 69234 32134 29473141
COVID-19 31.48 10.83 23 69229 35991 29469284
Blood potassium increased 31.13 10.83 90 69162 14561 29490714
Ejection fraction decreased 30.96 10.83 95 69157 15883 29489392
Neutrophil count decreased 30.69 10.83 34 69218 43533 29461742
Cardiac disorder 30.69 10.83 170 69082 37093 29468182
Mucosal inflammation 30.56 10.83 18 69234 31577 29473698
Cardioactive drug level below therapeutic 30.36 10.83 6 69246 0 29505275
Ischaemic stroke 30.04 10.83 94 69158 15883 29489392
Electrocardiogram ST segment depression 29.97 10.83 31 69221 2154 29503121
Coagulopathy 29.75 10.83 101 69151 17806 29487469
Stomatitis 29.56 10.83 26 69226 37087 29468188
Cardiorenal syndrome 29.55 10.83 19 69233 667 29504608
Intentional overdose 29.49 10.83 28 69224 38500 29466775
Dissociation 29.40 10.83 23 69229 1106 29504169
Suicidal ideation 28.04 10.83 24 69228 34692 29470583
Haematoma 27.85 10.83 118 69134 23094 29482181
N-terminal prohormone brain natriuretic peptide increased 27.57 10.83 28 69224 1904 29503371
International normalised ratio abnormal 26.98 10.83 34 69218 2929 29502346
Malignant neoplasm progression 26.92 10.83 86 69166 73773 29431502
Bundle branch block left 26.83 10.83 46 69206 5231 29500044
Anuria 26.77 10.83 65 69187 9476 29495799
Drug dependence 26.62 10.83 8 69244 20973 29484302
Oedema 26.52 10.83 174 69078 40309 29464966
Heart rate decreased 26.38 10.83 122 69130 24790 29480485
Therapeutic product effect incomplete 26.26 10.83 32 69220 39273 29466002
Jugular vein distension 26.16 10.83 17 69235 608 29504667
Pleural effusion 25.95 10.83 270 68982 71638 29433637
Depression 25.85 10.83 107 69145 85040 29420235
Cytomegalovirus infection 25.80 10.83 11 69241 23204 29482071
Hyperthyroidism 25.62 10.83 60 69192 8548 29496727
Fall 25.16 10.83 567 68685 176611 29328664
Infusion related reaction 25.05 10.83 40 69212 43846 29461429
Dilatation atrial 24.85 10.83 26 69226 1831 29503444
Diabetic ketoacidosis 24.68 10.83 4 69248 16069 29489206
Faeces discoloured 24.59 10.83 78 69174 13273 29492002
Drug resistance 24.27 10.83 10 69242 21530 29483745
Epistaxis 24.08 10.83 205 69047 51499 29453776
Treatment failure 23.71 10.83 31 69221 36908 29468367
Upper gastrointestinal haemorrhage 23.71 10.83 108 69144 21806 29483469
Orthopnoea 23.51 10.83 40 69212 4520 29500755
Hypersensitivity 23.45 10.83 56 69196 52847 29452428
Drug reaction with eosinophilia and systemic symptoms 23.03 10.83 19 69233 27973 29477302
Cardiac death 22.79 10.83 18 69234 878 29504397
Lethargy 22.51 10.83 158 69094 37422 29467853
Palpitations 22.50 10.83 142 69110 32462 29472813
Back pain 22.31 10.83 144 69108 102140 29403135
Dilatation ventricular 22.22 10.83 28 69224 2412 29502863
Myasthenic syndrome 21.92 10.83 13 69239 394 29504881
Lymphadenopathy 21.88 10.83 16 69236 25033 29480242
Cardiac output decreased 21.85 10.83 17 69235 811 29504464
Blood pressure increased 21.62 10.83 94 69158 73709 29431566
Lip discolouration 21.59 10.83 9 69243 124 29505151
Ventricular hypertrophy 21.46 10.83 37 69215 4227 29501048
Pain 21.40 10.83 278 68974 171154 29334121
Concomitant disease progression 21.35 10.83 27 69225 2334 29502941
Renal impairment 21.21 10.83 287 68965 81046 29424229
Peripheral embolism 21.15 10.83 18 69234 976 29504299
Fluid retention 21.10 10.83 110 69142 23450 29481825
Benign gastrointestinal neoplasm 20.84 10.83 9 69243 136 29505139
Acute myocardial infarction 20.46 10.83 188 69064 48250 29457025
Transient ischaemic attack 20.40 10.83 108 69144 23162 29482113
Polymerase chain reaction 20.26 10.83 8 69244 95 29505180
Drug intolerance 20.05 10.83 53 69199 48326 29456949
Creatinine renal clearance decreased 20.02 10.83 30 69222 3044 29502231
Haemorrhage intracranial 19.89 10.83 77 69175 14465 29490810
Dyspnoea exertional 19.89 10.83 150 69102 36340 29468935
Activated partial thromboplastin time prolonged 19.89 10.83 51 69201 7691 29497584
Psoriatic arthropathy 19.76 10.83 5 69247 14686 29490589
Muscle spasms 19.61 10.83 82 69170 65000 29440275
Ventricular dysfunction 19.58 10.83 31 69221 3300 29501975
Suicide attempt 19.55 10.83 31 69221 34079 29471196
Intentional self-injury 19.36 10.83 3 69249 12458 29492817
Joint swelling 19.36 10.83 56 69196 49574 29455701
Injury 19.23 10.83 92 69160 18954 29486321
Brain natriuretic peptide increased 19.09 10.83 35 69217 4195 29501080
Anhedonia 19.09 10.83 48 69204 7152 29498123
Inappropriate schedule of product administration 18.98 10.83 48 69204 44424 29460851
Coronary artery bypass 18.96 10.83 37 69215 4648 29500627
Sinusitis 18.96 10.83 32 69220 34318 29470957
Oesophageal achalasia 18.93 10.83 11 69241 321 29504954
Psoriasis 18.75 10.83 29 69223 32198 29473077
Peripheral coldness 18.05 10.83 43 69209 6193 29499082
Atrioventricular block second degree 17.96 10.83 29 69223 3139 29502136
Burning feet syndrome 17.89 10.83 7 69245 81 29505194
Congestive hepatopathy 17.77 10.83 21 69231 1693 29503582
Drug withdrawal syndrome 17.74 10.83 10 69242 17974 29487301
Chromatopsia 17.70 10.83 9 69243 200 29505075
Haemorrhage 17.58 10.83 172 69080 44900 29460375
Subdural haemorrhage 17.52 10.83 27 69225 2808 29502467
Drug-induced liver injury 17.45 10.83 15 69237 21640 29483635
Enzyme induction 17.40 10.83 6 69246 47 29505228
Electrocardiogram QRS complex prolonged 17.29 10.83 33 69219 4077 29501198
Arthropathy 17.28 10.83 15 69237 21539 29483736
Electrocardiogram repolarisation abnormality 17.19 10.83 14 69238 714 29504561
Pancytopenia 17.17 10.83 119 69133 83049 29422226
Brain natriuretic peptide 16.92 10.83 5 69247 22 29505253
Procalcitonin abnormal 16.90 10.83 10 69242 302 29504973
Cerebral infarction 16.73 10.83 107 69145 24568 29480707
Cyanosis 16.52 10.83 61 69191 11206 29494069
Urticaria 16.39 10.83 69 69183 54591 29450684
Abnormal loss of weight 16.31 10.83 30 69222 3604 29501671
Diverticulum intestinal haemorrhagic 16.19 10.83 22 69230 2040 29503235
Normochromic normocytic anaemia 16.17 10.83 30 69222 3628 29501647
Synovitis 16.08 10.83 3 69249 10887 29494388
Angina unstable 16.08 10.83 59 69193 10806 29494469
Mitral valve sclerosis 16.02 10.83 7 69245 109 29505166
Pulmonary arterial pressure increased 15.97 10.83 16 69236 1070 29504205
Eosinophilia 15.93 10.83 17 69235 22144 29483131
Blood pressure fluctuation 15.76 10.83 14 69238 19880 29485395
Tricuspid valve sclerosis 15.64 10.83 5 69247 30 29505245
Pneumocystis jirovecii pneumonia 15.61 10.83 10 69242 16769 29488506
Haematemesis 15.61 10.83 105 69147 24521 29480754
Aspergillus infection 15.45 10.83 3 69249 10578 29494697
Embolic stroke 15.23 10.83 29 69223 3577 29501698
Infective exacerbation of chronic obstructive airways disease 15.13 10.83 19 69233 1631 29503644
Cerebral haematoma 15.09 10.83 32 69220 4264 29501011
Haematocrit decreased 15.09 10.83 118 69134 28904 29476371
Cardio-respiratory arrest 15.06 10.83 183 69069 50418 29454857
Somnolence 15.02 10.83 144 69108 93811 29411464
Anaphylactic reaction 14.93 10.83 26 69226 27547 29477728
Palmar-plantar erythrodysaesthesia syndrome 14.86 10.83 8 69244 14751 29490524
Irritability 14.83 10.83 18 69234 22134 29483141
Tracheal injury 14.72 10.83 4 69248 12 29505263
Colitis 14.72 10.83 32 69220 31216 29474059
Paraneoplastic syndrome 14.66 10.83 11 69241 497 29504778
Right atrial dilatation 14.63 10.83 9 69243 292 29504983
Dehydration 14.36 10.83 361 68891 114387 29390888
Polypectomy 14.35 10.83 11 69241 513 29504762
Withdrawal syndrome 14.30 10.83 4 69248 10988 29494287
Colitis ulcerative 14.27 10.83 6 69246 12763 29492512
Hyponatraemia 14.23 10.83 230 69022 67403 29437872
Gastric mucosal lesion 14.15 10.83 11 69241 524 29504751
Sleep disorder 14.13 10.83 22 69230 24364 29480911
Electrocardiogram ST-T change 14.12 10.83 11 69241 526 29504749
Neuralgia 14.06 10.83 4 69248 10870 29494405
Herpes zoster 13.97 10.83 31 69221 30021 29475254
Emotional distress 13.94 10.83 67 69185 13828 29491447
Hypovolaemia 13.91 10.83 46 69206 7999 29497276
Atrial thrombosis 13.77 10.83 20 69232 1973 29503302
Chills 13.76 10.83 104 69148 71196 29434079
Dystonia 13.74 10.83 3 69249 9746 29495529
Influenza 13.74 10.83 51 69201 41830 29463445
Haemothorax 13.74 10.83 27 69225 3409 29501866
Cardiac failure acute 13.67 10.83 50 69202 9142 29496133
Presyncope 13.64 10.83 74 69178 16015 29489260
Rectal haemorrhage 13.54 10.83 132 69120 34417 29470858
Limited symptom panic attack 13.51 10.83 5 69247 49 29505226
Graft versus host disease 13.50 10.83 3 69249 9625 29495650
Infection 13.41 10.83 115 69137 76636 29428639
Carotid artery disease 13.31 10.83 13 69239 843 29504432
Acute respiratory failure 12.99 10.83 106 69146 26296 29478979
Toxic epidermal necrolysis 12.96 10.83 14 69238 18139 29487136
Tremor 12.93 10.83 110 69142 73428 29431847
Cerebral haemorrhage 12.78 10.83 121 69131 31305 29473970
Encephalomalacia 12.78 10.83 12 69240 741 29504534
Pain in extremity 12.71 10.83 182 69070 110251 29395024
Dyspnoea paroxysmal nocturnal 12.70 10.83 16 69236 1378 29503897
Foetal exposure during pregnancy 12.64 10.83 39 69213 33828 29471447
Oliguria 12.48 10.83 42 69210 7370 29497905
Loss of consciousness 12.43 10.83 243 69009 73813 29431462
Electrocardiogram ST segment abnormal 12.28 10.83 10 69242 510 29504765
Posterior reversible encephalopathy syndrome 12.18 10.83 3 69249 8973 29496302
Rash maculo-papular 12.18 10.83 24 69228 24265 29481010
Insomnia 12.16 10.83 141 69111 88620 29416655
PO2 decreased 12.12 10.83 16 69236 1443 29503832
Blood loss anaemia 12.08 10.83 41 69211 7225 29498050
Musculoskeletal stiffness 12.04 10.83 46 69206 37412 29467863
Cardiovascular disorder 11.97 10.83 47 69205 8888 29496387
Tumour lysis syndrome 11.96 10.83 9 69243 13875 29491400
Bundle branch block 11.91 10.83 12 69240 808 29504467
Morning glory syndrome 11.90 10.83 3 69249 6 29505269
Appendicitis 11.79 10.83 3 69249 8776 29496499
Multiple sclerosis relapse 11.78 10.83 6 69246 11413 29493862
Myelosuppression 11.77 10.83 7 69245 12220 29493055
Sinus bradycardia 11.68 10.83 56 69196 11547 29493728
Blood pressure decreased 11.65 10.83 160 69092 45317 29459958
Supraventricular extrasystoles 11.62 10.83 23 69229 2918 29502357
Thrombotic microangiopathy 11.59 10.83 3 69249 8678 29496597
Mania 11.55 10.83 3 69249 8660 29496615
Hepatocellular injury 11.53 10.83 20 69232 21223 29484052
Constipation 11.49 10.83 193 69059 113967 29391308
Encephalopathy 11.40 10.83 36 69216 31007 29474268
Ischaemic hepatitis 11.38 10.83 16 69236 1532 29503743
Lymphopenia 11.36 10.83 9 69243 13524 29491751
Sudden cardiac death 11.32 10.83 24 69228 3198 29502077
Bundle branch block bilateral 11.31 10.83 4 69248 34 29505241
Acute hepatic failure 11.29 10.83 7 69245 11945 29493330
Retroperitoneal haematoma 11.27 10.83 20 69232 2338 29502937
Drug level increased 11.25 10.83 79 69173 18708 29486567
Adrenal insufficiency 11.22 10.83 6 69246 11108 29494167
Pulmonary oedema 11.21 10.83 151 69101 42584 29462691
Extrasystoles 11.21 10.83 25 69227 3449 29501826
Tinnitus 11.20 10.83 12 69240 15602 29489673
Erythema 11.19 10.83 118 69134 75488 29429787
Prothrombin level decreased 11.03 10.83 13 69239 1045 29504230
Glomerular filtration rate abnormal 11.01 10.83 11 69241 733 29504542
Heparin-induced thrombocytopenia 10.98 10.83 31 69221 4948 29500327
Haemodynamic test abnormal 10.92 10.83 4 69248 38 29505237
Diarrhoea 10.91 10.83 653 68599 332045 29173230
Aortic valve stenosis 10.90 10.83 19 69233 2189 29503086
Transaminases increased 10.84 10.83 23 69229 22639 29482636
Injection site erythema 10.84 10.83 10 69242 13946 29491329
Transplant rejection 10.83 10.83 4 69248 9208 29496067

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Cardioactive drug level increased 1787.31 10.15 532 127973 2933 64367294
Bradycardia 1535.61 10.15 1509 126996 116710 64253517
International normalised ratio increased 1276.31 10.15 1140 127365 78027 64292200
Cardiac failure congestive 1025.26 10.15 1281 127224 129299 64240928
Atrial fibrillation 850.17 10.15 1348 127157 169741 64200486
Drug interaction 572.71 10.15 1801 126704 360282 64009945
Toxicity to various agents 533.01 10.15 1762 126743 361751 64008476
Cardiac failure 492.38 10.15 918 127587 131455 64238772
Hyperkalaemia 481.30 10.15 782 127723 100347 64269880
Ventricular tachycardia 374.14 10.15 399 128106 33866 64336361
Drug ineffective 363.95 10.15 704 127801 839543 63530684
Off label use 335.46 10.15 464 128041 632342 63737885
Product complaint 324.66 10.15 234 128271 11720 64358507
Acute kidney injury 306.52 10.15 1728 126777 447512 63922715
Gastrointestinal haemorrhage 245.04 10.15 697 127808 131615 64238612
Right ventricular failure 232.54 10.15 249 128256 21222 64349005
Arthralgia 230.21 10.15 328 128177 441932 63928295
Melaena 221.24 10.15 389 128116 53159 64317068
Bradyarrhythmia 217.68 10.15 119 128386 3639 64366588
Pulmonary hypertension 215.15 10.15 341 128164 42798 64327429
Hypotension 213.39 10.15 1393 127112 379581 63990646
Torsade de pointes 207.06 10.15 212 128293 17151 64353076
Dyspnoea 202.78 10.15 2253 126252 716421 63653806
Drug abuse 197.65 10.15 18 128487 132356 64237871
Myocardial infarction 195.95 10.15 750 127755 165071 64205156
Renal failure 193.17 10.15 795 127710 180893 64189334
Pulmonary arterial hypertension 183.01 10.15 239 128266 25128 64345099
Pain 172.07 10.15 549 127956 552962 63817265
Cardioactive drug level above therapeutic 171.78 10.15 48 128457 202 64370025
Drug hypersensitivity 171.03 10.15 134 128371 237681 64132546
Arrhythmia 167.16 10.15 343 128162 52601 64317626
Rheumatoid arthritis 165.81 10.15 60 128445 164234 64205993
Synovitis 163.92 10.15 8 128497 99082 64271145
Nodal rhythm 152.75 10.15 86 128419 2788 64367439
Rash 151.54 10.15 442 128063 458107 63912120
Joint swelling 149.07 10.15 126 128379 215256 64154971
Drug intolerance 148.16 10.15 96 128409 187896 64182331
Atrioventricular block 147.44 10.15 149 128356 11866 64358361
Syncope 139.49 10.15 653 127852 156982 64213245
Infusion related reaction 136.54 10.15 79 128426 164388 64205839
Cardiac arrest 136.17 10.15 638 127867 153426 64216801
Atrioventricular block complete 135.06 10.15 155 128350 14263 64355964
Cerebrovascular accident 129.18 10.15 580 127925 137003 64233224
Febrile neutropenia 125.94 10.15 113 128392 187544 64182683
Cardiac murmur 121.51 10.15 132 128373 11431 64358796
Atrial flutter 120.66 10.15 170 128335 19210 64351017
Ventricular fibrillation 119.48 10.15 189 128316 23671 64346556
Pruritus 119.20 10.15 280 128225 312120 64058107
Nasopharyngitis 118.98 10.15 129 128376 195944 64174283
Cardioactive drug level decreased 117.32 10.15 33 128472 143 64370084
Injection site pain 117.03 10.15 38 128467 111370 64258857
Neutropenia 114.54 10.15 188 128317 239436 64130791
Venous pressure jugular increased 114.10 10.15 54 128451 1209 64369018
Treatment failure 113.93 10.15 45 128460 116771 64253456
Subdural haematoma 112.23 10.15 201 128304 27853 64342374
Alopecia 112.10 10.15 99 128406 165591 64204636
International normalised ratio decreased 111.07 10.15 103 128402 7375 64362852
Dizziness 111.06 10.15 1327 127178 428836 63941391
Hand deformity 110.93 10.15 3 128502 62768 64307459
Ventricular extrasystoles 109.48 10.15 154 128351 17375 64352852
Arthropathy 107.88 10.15 53 128452 120914 64249313
Asthenia 107.24 10.15 1313 127192 426731 63943496
Intentional product use issue 104.73 10.15 30 128475 95334 64274893
Stomatitis 104.00 10.15 44 128461 109561 64260666
Upper gastrointestinal haemorrhage 103.95 10.15 222 128283 34998 64335229
Therapeutic product effect decreased 103.68 10.15 50 128455 115301 64254926
Hypersensitivity 103.65 10.15 144 128361 196308 64173919
Pemphigus 103.36 10.15 4 128501 60697 64309530
Oedema peripheral 101.42 10.15 742 127763 209575 64160652
Tricuspid valve incompetence 98.31 10.15 144 128361 16859 64353368
Nodal arrhythmia 94.85 10.15 54 128451 1789 64368438
Atrioventricular block first degree 93.21 10.15 111 128394 10623 64359604
Electrocardiogram ST segment depression 92.80 10.15 74 128431 4315 64365912
International normalised ratio abnormal 92.66 10.15 78 128427 4910 64365317
Cardiomegaly 92.58 10.15 168 128337 23516 64346711
Blood urea increased 91.97 10.15 243 128262 43910 64326317
Sinusitis 91.89 10.15 93 128412 145835 64224392
Product use issue 91.82 10.15 100 128405 151615 64218612
Sinus node dysfunction 91.79 10.15 89 128416 6739 64363488
Ischaemic cardiomyopathy 89.81 10.15 88 128417 6750 64363477
Systemic lupus erythematosus 89.80 10.15 22 128483 77590 64292637
Contraindicated product administered 89.17 10.15 52 128453 107777 64262450
Prothrombin time prolonged 89.11 10.15 132 128373 15609 64354618
Product use in unapproved indication 88.70 10.15 134 128371 176484 64193743
Completed suicide 87.26 10.15 199 128306 224215 64146012
Coronary artery disease 87.20 10.15 292 128213 60141 64310086
Confusional state 86.95 10.15 848 127657 260296 64109931
Blood creatinine increased 86.67 10.15 514 127991 135268 64234959
Mitral valve incompetence 84.80 10.15 169 128336 25369 64344858
Fluid retention 84.24 10.15 286 128219 59320 64310907
Musculoskeletal stiffness 84.06 10.15 73 128432 123133 64247094
Xanthopsia 82.97 10.15 29 128476 284 64369943
Ischaemic stroke 81.10 10.15 179 128326 28856 64341371
Glossodynia 77.51 10.15 17 128488 64679 64305548
Haematoma 75.37 10.15 233 128272 46017 64324210
Therapeutic product effect incomplete 74.70 10.15 58 128447 103424 64266803
Cardiac failure chronic 74.43 10.15 91 128414 8950 64361277
Hepatic enzyme increased 73.91 10.15 90 128415 129853 64240374
Orthopnoea 73.69 10.15 91 128414 9043 64361184
Ventricular arrhythmia 73.33 10.15 82 128423 7333 64362894
Leukopenia 72.76 10.15 57 128448 101185 64269042
Dehydration 70.22 10.15 700 127805 216063 64154164
Psoriatic arthropathy 69.98 10.15 4 128501 43277 64326950
Haematuria 69.25 10.15 271 128234 60200 64310027
Drug level increased 68.99 10.15 186 128319 34010 64336217
White blood cell count decreased 68.01 10.15 132 128373 157705 64212522
Injection site erythema 67.83 10.15 28 128477 70772 64299455
Rectal haemorrhage 67.55 10.15 273 128232 61544 64308683
Ejection fraction decreased 66.00 10.15 164 128341 28543 64341684
Presyncope 65.97 10.15 186 128319 34903 64335324
Pyrexia 65.11 10.15 756 127749 557888 63812339
Hypervolaemia 64.36 10.15 195 128310 38090 64332137
Blood potassium increased 63.54 10.15 152 128353 25828 64344399
Pleural effusion 63.53 10.15 451 128054 126108 64244119
Left ventricular failure 63.35 10.15 81 128424 8336 64361891
Wound 63.05 10.15 37 128468 76440 64293787
Psoriasis 63.03 10.15 32 128473 71671 64298556
Epistaxis 62.93 10.15 372 128133 97759 64272468
Injection site pruritus 62.71 10.15 3 128502 37823 64332404
Hyponatraemia 61.80 10.15 506 127999 147833 64222394
Sinus bradycardia 61.54 10.15 139 128366 22754 64347473
Pericarditis 61.07 10.15 24 128481 62492 64307735
Haemorrhage intracranial 60.87 10.15 142 128363 23742 64346485
Atrial tachycardia 60.71 10.15 53 128452 3506 64366721
Oedema 60.56 10.15 351 128154 91584 64278643
Dyspnoea exertional 60.49 10.15 299 128206 73431 64296796
Neuropathy peripheral 60.12 10.15 88 128417 117437 64252790
Coagulopathy 59.81 10.15 169 128336 31751 64338476
Atrioventricular block second degree 59.80 10.15 69 128436 6385 64363842
Cardiogenic shock 59.12 10.15 170 128335 32257 64337970
Infection 58.17 10.15 182 128323 184698 64185529
Urticaria 57.75 10.15 130 128375 147187 64223040
Maternal exposure during pregnancy 57.11 10.15 64 128441 95820 64274407
Cardioactive drug level below therapeutic 56.53 10.15 12 128493 8 64370219
Injection site reaction 56.43 10.15 12 128493 46652 64323575
Product dose omission issue 55.60 10.15 200 128305 194547 64175680
Intentional product misuse 55.45 10.15 38 128467 72257 64297970
Cardiomyopathy 55.31 10.15 142 128363 25214 64345013
Cerebral haemorrhage 54.53 10.15 224 128281 50866 64319361
Headache 53.64 10.15 738 127767 528729 63841498
Embolic stroke 52.76 10.15 66 128439 6645 64363582
Suicidal ideation 52.35 10.15 34 128471 66508 64303719
Swelling 51.62 10.15 156 128349 160062 64210165
Rheumatoid factor positive 51.46 10.15 5 128500 34933 64335294
Lower gastrointestinal haemorrhage 50.86 10.15 96 128409 13843 64356384
Fibromyalgia 50.36 10.15 6 128499 35725 64334502
Left ventricular dysfunction 50.17 10.15 107 128398 16847 64353380
Neutrophil count decreased 49.95 10.15 48 128457 77148 64293079
Bundle branch block left 49.56 10.15 79 128426 9955 64360272
Heart rate irregular 49.29 10.15 143 128362 27270 64342957
Chronic obstructive pulmonary disease 49.25 10.15 275 128230 70773 64299454
Activated partial thromboplastin time prolonged 48.86 10.15 90 128415 12741 64357486
Tachyarrhythmia 48.55 10.15 60 128445 5966 64364261
Conduction disorder 48.23 10.15 43 128462 2925 64367302
Renal injury 47.54 10.15 99 128406 15330 64354897
Renal impairment 47.11 10.15 443 128062 134574 64235653
Multiple sclerosis relapse 46.92 10.15 12 128493 41123 64329104
Back pain 46.79 10.15 299 128206 249872 64120355
Heart rate decreased 46.37 10.15 225 128280 54842 64315385
Cardiac disorder 46.24 10.15 227 128278 55589 64314638
Brain natriuretic peptide increased 44.64 10.15 65 128440 7568 64362659
Cytomegalovirus infection 44.10 10.15 10 128495 37189 64333038
Injection site swelling 43.60 10.15 14 128491 41339 64328888
Musculoskeletal pain 43.43 10.15 59 128446 81235 64288992
Asthma 43.34 10.15 77 128428 95148 64275079
Hyperthyroidism 43.00 10.15 105 128400 18074 64352153
Pain in extremity 42.66 10.15 392 128113 302693 64067534
Congestive cardiomyopathy 42.50 10.15 75 128430 10269 64359958
Supraventricular tachycardia 42.39 10.15 107 128398 18800 64351427
Malignant neoplasm progression 42.30 10.15 102 128403 112769 64257458
Electrocardiogram abnormal 42.13 10.15 87 128418 13394 64356833
Lethargy 41.99 10.15 268 128237 72326 64297901
Medication error 41.95 10.15 204 128301 49762 64320465
Migraine 41.70 10.15 38 128467 62639 64307588
Muscle injury 41.09 10.15 3 128502 26434 64343793
Abdominal discomfort 41.07 10.15 205 128300 182117 64188110
Hypoaesthesia 40.94 10.15 141 128364 138967 64231260
Discomfort 40.92 10.15 61 128444 80817 64289410
Fall 40.79 10.15 1103 127402 415723 63954504
Arthritis 40.70 10.15 65 128440 83749 64286478
Intentional self-injury 40.63 10.15 5 128500 29039 64341188
Irritable bowel syndrome 40.57 10.15 12 128493 37357 64332870
Blood pressure fluctuation 40.13 10.15 27 128478 51844 64318383
Abdominal wall haematoma 39.84 10.15 46 128459 4259 64365968
Impaired healing 39.83 10.15 37 128468 60436 64309791
COVID-19 39.31 10.15 43 128462 65097 64305130
Decreased appetite 39.15 10.15 782 127723 280507 64089720
Electrocardiogram ST segment abnormal 39.11 10.15 27 128478 1261 64368966
Dilatation atrial 39.10 10.15 41 128464 3409 64366818
Inappropriate schedule of product administration 39.03 10.15 78 128427 92208 64278019
Haematemesis 38.83 10.15 191 128314 46808 64323419
Loss of consciousness 38.69 10.15 459 128046 147906 64222321
Dilatation ventricular 38.62 10.15 43 128462 3827 64366400
Faeces discoloured 38.60 10.15 126 128379 25603 64344624
Hypoxia 38.49 10.15 304 128201 87845 64282382
Haemorrhage 38.20 10.15 280 128225 79071 64291156
Depression 37.99 10.15 212 128293 183079 64187148
Herpes zoster 37.90 10.15 62 128443 79125 64291102
Duodenal ulcer perforation 37.80 10.15 11 128494 34614 64335613
Oropharyngeal pain 37.67 10.15 75 128430 88792 64281435
Sleep disorder 37.62 10.15 38 128467 59671 64310556
Cardiorenal syndrome 37.48 10.15 26 128479 1224 64369003
Drug dependence 37.46 10.15 10 128495 33302 64336925
Ventricular hypertrophy 37.40 10.15 55 128450 6461 64363766
Orthostatic hypotension 37.24 10.15 188 128317 46550 64323677
Palpitations 37.02 10.15 344 128161 104144 64266083
Cerebral infarction 36.95 10.15 171 128334 40873 64329354
Aortic stenosis 36.93 10.15 54 128451 6311 64363916
Muscle spasms 36.90 10.15 150 128355 140873 64229354
Hypocoagulable state 36.55 10.15 30 128475 1823 64368404
Blood pressure increased 36.07 10.15 199 128306 172353 64197874
Congestive hepatopathy 36.01 10.15 42 128463 3931 64366296
Insomnia 35.68 10.15 239 128266 197597 64172630
Helicobacter infection 35.42 10.15 16 128489 38346 64331881
Transient ischaemic attack 35.40 10.15 178 128327 44004 64326223
Acute myocardial infarction 35.29 10.15 249 128256 69469 64300758
Osteoporosis 35.19 10.15 20 128485 42060 64328167
Chest pain 35.18 10.15 663 127842 235317 64134910
Electrocardiogram QT shortened 35.06 10.15 14 128491 204 64370023
Pulmonary arterial pressure increased 34.81 10.15 42 128463 4074 64366153
Intentional overdose 34.72 10.15 80 128425 89864 64280363
N-terminal prohormone brain natriuretic peptide increased 34.58 10.15 39 128466 3520 64366707
Hypoglycaemia 34.43 10.15 301 128204 89591 64280636
Bundle branch block right 34.14 10.15 68 128437 10201 64360026
Cardiac failure acute 34.07 10.15 90 128415 16254 64353973
Ventricular dysfunction 33.95 10.15 47 128458 5223 64365004
Blood lactic acid 33.46 10.15 17 128488 446 64369781
Anhedonia 33.31 10.15 80 128425 13626 64356601
Therapeutic response decreased 33.12 10.15 33 128472 52155 64318072
Oral herpes 33.08 10.15 3 128502 22149 64348078
Myocardial ischaemia 32.34 10.15 111 128394 23140 64347087
Anuria 32.25 10.15 97 128408 18867 64351360
Unevaluable event 32.09 10.15 191 128314 50298 64319929
Hypochromic anaemia 32.08 10.15 31 128474 2337 64367890
Pulmonary oedema 32.00 10.15 267 128238 78407 64291820
Mucosal inflammation 31.86 10.15 47 128458 62537 64307690
Drug resistance 31.86 10.15 15 128490 35087 64335140
Diabetic ketoacidosis 31.64 10.15 10 128495 29835 64340392
Paraesthesia 31.59 10.15 149 128356 134373 64235854
Shock haemorrhagic 31.55 10.15 89 128416 16702 64353525
Transfusion 31.52 10.15 93 128412 17901 64352326
Anaemia 31.51 10.15 982 127523 377698 63992529
Irritability 31.40 10.15 17 128488 36729 64333498
Peripheral embolism 31.13 10.15 27 128478 1770 64368457
Calcium deficiency 31.09 10.15 19 128486 719 64369508
Angina unstable 31.06 10.15 84 128421 15383 64354844
Fear 30.46 10.15 99 128406 20072 64350155
Electrocardiogram QT prolonged 30.41 10.15 266 128239 79182 64291045
Lymphocyte count decreased 30.40 10.15 22 128483 40677 64329550
Blood cholesterol increased 30.26 10.15 33 128472 50033 64320194
Subarachnoid haemorrhage 30.13 10.15 93 128412 18345 64351882
Pneumocystis jirovecii pneumonia 29.77 10.15 9 128496 27625 64342602
Mobility decreased 29.52 10.15 81 128424 85759 64284468
Jugular vein distension 29.48 10.15 23 128482 1299 64368928
Gastrointestinal disorder 29.13 10.15 87 128418 89622 64280605
Weight increased 28.68 10.15 279 128226 213069 64157158
Suicide attempt 28.35 10.15 62 128443 70945 64299282
Loss of personal independence in daily activities 28.32 10.15 64 128441 72390 64297837
Extrasystoles 28.30 10.15 49 128456 6609 64363618
Tremor 28.29 10.15 176 128329 148054 64222173
Hypovolaemia 28.04 10.15 81 128424 15405 64354822
Respiratory failure 27.98 10.15 464 128041 160719 64209508
Chills 27.76 10.15 160 128345 137104 64233123
Neuralgia 27.36 10.15 9 128496 26175 64344052
Cardiac death 27.24 10.15 22 128483 1306 64368921
Peripheral swelling 27.08 10.15 276 128229 208877 64161350
Concomitant disease progression 27.07 10.15 33 128472 3236 64366991
Neoplasm progression 27.05 10.15 25 128480 40939 64329288
Mitral valve stenosis 27.01 10.15 20 128485 1044 64369183
Chromatopsia 26.98 10.15 16 128489 573 64369654
Knee arthroplasty 26.97 10.15 10 128495 26989 64343238
Alveolitis 26.95 10.15 35 128470 3657 64366570
Pyroglutamic acidosis 26.12 10.15 17 128488 719 64369508
Red blood cell sedimentation rate increased 25.90 10.15 15 128490 31220 64339007
Progressive multifocal leukoencephalopathy 25.85 10.15 3 128502 18229 64351998
Anaphylactic reaction 25.76 10.15 62 128443 68602 64301625
Osteonecrosis of jaw 25.48 10.15 25 128480 39800 64330427
Drug reaction with eosinophilia and systemic symptoms 25.43 10.15 43 128462 54174 64316053
Occult blood positive 25.08 10.15 45 128460 6242 64363985
Drug therapeutic incompatibility 24.90 10.15 10 128495 148 64370079
Haemoptysis 24.71 10.15 175 128330 48873 64321354
Ill-defined disorder 24.52 10.15 31 128474 44021 64326206
Acute respiratory failure 24.48 10.15 177 128328 49757 64320470
Transplant rejection 24.33 10.15 3 128502 17398 64352829
Electrocardiogram repolarisation abnormality 24.31 10.15 24 128481 1858 64368369
Aortic valve incompetence 24.11 10.15 52 128453 8249 64361978
Atrial thrombosis 24.04 10.15 30 128475 3012 64367215
Acne 24 10.15 8 128497 23073 64347154
Coagulation time prolonged 23.43 10.15 25 128480 2121 64368106
Oliguria 23.34 10.15 73 128432 14503 64355724
Left atrial dilatation 23.03 10.15 28 128477 2738 64367489
Lymphadenopathy 22.86 10.15 36 128469 46650 64323577
Cor pulmonale 22.83 10.15 24 128481 2001 64368226
Cyanosis 22.74 10.15 96 128409 22059 64348168
Influenza 22.72 10.15 122 128383 106409 64263818
Foot deformity 22.70 10.15 3 128502 16501 64353726
Aspergillus infection 22.48 10.15 3 128502 16376 64353851
Cardioversion 22.44 10.15 23 128482 1862 64368365
Coronary artery bypass 22.41 10.15 41 128464 5774 64364453
Prothrombin time shortened 22.36 10.15 28 128477 2821 64367406
Colitis ulcerative 22.23 10.15 9 128496 23019 64347208
Drug monitoring procedure not performed 22.11 10.15 16 128489 806 64369421
Fatigue 22.06 10.15 1244 127261 747486 63622741
Benign gastrointestinal neoplasm 22.00 10.15 9 128496 140 64370087
Injection site mass 21.80 10.15 4 128501 17266 64352961
Haematocrit decreased 21.44 10.15 184 128321 54471 64315756
Fungal infection 21.35 10.15 22 128483 34229 64335998
Exposure during pregnancy 21.34 10.15 81 128424 77594 64292633
Overdose 21.30 10.15 441 128064 159125 64211102
Constipation 21.27 10.15 325 128180 229012 64141215
Drug-induced liver injury 21.24 10.15 39 128466 47604 64322623
Hip arthroplasty 21.18 10.15 8 128497 21343 64348884
Haemoglobin decreased 21.01 10.15 523 127982 194540 64175687
Palmar-plantar erythrodysaesthesia syndrome 20.98 10.15 16 128489 28803 64341424
Blood loss anaemia 20.81 10.15 68 128437 13824 64356403
Atrioventricular dissociation 20.81 10.15 11 128494 314 64369913
Supraventricular extrasystoles 20.67 10.15 40 128465 5875 64364352
Dystonia 20.58 10.15 6 128499 18859 64351368
Illness 20.49 10.15 9 128496 21929 64348298
Electrocardiogram ST-T change 20.46 10.15 20 128485 1529 64368698
Colitis 20.45 10.15 55 128450 58619 64311608
Pulse absent 20.44 10.15 51 128454 8895 64361332
Myelosuppression 20.40 10.15 11 128494 23819 64346408
Electrocardiogram QRS complex prolonged 20.40 10.15 52 128453 9192 64361035
Lymphopenia 20.32 10.15 13 128492 25644 64344583
Cataract 20.26 10.15 45 128460 51217 64319010
Catheter management 20.24 10.15 29 128476 3326 64366901
Basal cell carcinoma 20.15 10.15 19 128486 30819 64339408
Osteoarthritis 20.15 10.15 62 128443 63274 64306953
C-reactive protein abnormal 20.05 10.15 17 128488 29030 64341197
Disorientation 19.87 10.15 184 128321 55644 64314583
Immunodeficiency 19.80 10.15 4 128501 16120 64354107
Lactic acidosis 19.69 10.15 198 128307 61212 64309015
Pulmonary congestion 19.69 10.15 97 128408 23783 64346444
Polymerase chain reaction 19.64 10.15 8 128497 123 64370104
Joint stiffness 19.55 10.15 19 128486 30385 64339842
Dialysis 19.50 10.15 76 128429 16844 64353383
Head injury 19.45 10.15 122 128383 32720 64337507
Erythema 19.13 10.15 260 128245 186810 64183417
Neurotoxicity 18.97 10.15 16 128489 27388 64342839
Feeling hot 18.95 10.15 39 128466 45624 64324603
Urine output decreased 18.94 10.15 74 128431 16418 64353809
Cardiac output decreased 18.87 10.15 20 128485 1684 64368543
Blister 18.82 10.15 90 128415 80877 64289350
Blood pressure decreased 18.77 10.15 258 128247 85941 64284286
Sopor 18.71 10.15 112 128393 29549 64340678
C-reactive protein increased 18.46 10.15 112 128393 94797 64275430
Myasthenic syndrome 18.37 10.15 13 128492 632 64369595
Obesity 18.33 10.15 9 128496 20553 64349674
Procalcitonin abnormal 18.31 10.15 10 128495 305 64369922
Central nervous system injury 18.30 10.15 8 128497 148 64370079
Cardio-respiratory arrest 18.09 10.15 286 128219 98107 64272120
Right ventricular dilatation 17.87 10.15 18 128487 1427 64368800
Haemarthrosis 17.83 10.15 35 128470 5194 64365033
Burning sensation 17.73 10.15 46 128459 49618 64320609
Posterior reversible encephalopathy syndrome 17.67 10.15 12 128493 22934 64347293
Splenic injury 17.65 10.15 9 128496 238 64369989
Cerebral haematoma 17.53 10.15 42 128463 7143 64363084
Drug withdrawal syndrome 17.43 10.15 22 128483 31269 64338958
Bundle branch block bilateral 17.42 10.15 6 128499 56 64370171
Right atrial dilatation 17.32 10.15 13 128492 693 64369534
Hypertension 17.29 10.15 389 128116 258872 64111355
Sudden cardiac death 17.24 10.15 32 128473 4555 64365672
Haemothorax 17.23 10.15 33 128472 4809 64365418
Acute hepatic failure 17.16 10.15 16 128489 26096 64344131
Potentiating drug interaction 17.15 10.15 44 128461 7808 64362419
Cor pulmonale chronic 17.08 10.15 9 128496 255 64369972
Bone pain 17.03 10.15 44 128461 47528 64322699
Heparin-induced thrombocytopenia 16.98 10.15 46 128459 8433 64361794
Abdominal pain upper 16.92 10.15 246 128259 174784 64195443
Sensory disturbance 16.80 10.15 3 128502 13205 64357022
Dry eye 16.59 10.15 20 128485 28999 64341228
Erythrodermic psoriasis 16.54 10.15 18 128487 1561 64368666
Catheter placement 16.52 10.15 23 128482 2570 64367657
Drug level above therapeutic 16.47 10.15 40 128465 6861 64363366
Tricuspid valve sclerosis 16.43 10.15 5 128500 30 64370197
Burning feet syndrome 16.34 10.15 7 128498 123 64370104
Dry skin 16.33 10.15 50 128455 51111 64319116
Dyspnoea paroxysmal nocturnal 16.22 10.15 20 128485 1984 64368243
Pancytopenia 16.20 10.15 195 128310 143114 64227113
Kussmaul respiration 16.16 10.15 10 128495 387 64369840
Blood culture positive 16.07 10.15 43 128462 7825 64362402
Bronchopulmonary aspergillosis 16.06 10.15 9 128496 19076 64351151
Device issue 15.95 10.15 13 128492 22635 64347592
Uveitis 15.92 10.15 3 128502 12705 64357522
Tachycardia induced cardiomyopathy 15.89 10.15 7 128498 132 64370095
Graft versus host disease 15.81 10.15 4 128501 13809 64356418
Skin exfoliation 15.69 10.15 42 128463 44843 64325384
Encephalitis 15.68 10.15 3 128502 12568 64357659
Prothrombin level decreased 15.67 10.15 17 128488 1469 64368758
Rales 15.64 10.15 66 128439 15163 64355064
Exercise tolerance decreased 15.61 10.15 42 128463 7668 64362559
Multiple organ dysfunction syndrome 15.46 10.15 286 128219 101127 64269100
Retroperitoneal haematoma 15.43 10.15 31 128474 4680 64365547
Hypophagia 15.38 10.15 133 128372 39454 64330773
Peripheral ischaemia 15.34 10.15 44 128461 8334 64361893
Hepatocellular injury 15.31 10.15 43 128462 45192 64325035
Heart sounds abnormal 15.27 10.15 15 128490 1154 64369073
Haemophagocytic lymphohistiocytosis 15.26 10.15 8 128497 17601 64352626
Normochromic normocytic anaemia 15.14 10.15 38 128467 6652 64363575
Diverticulum intestinal haemorrhagic 15.14 10.15 25 128480 3244 64366983
Labelled drug-drug interaction medication error 15.02 10.15 85 128420 21977 64348250
Chronic kidney disease 15.00 10.15 179 128326 57740 64312487
Intervertebral disc protrusion 14.97 10.15 11 128494 20180 64350047
Hypersensitivity vasculitis 14.88 10.15 38 128467 6723 64363504
Electrocardiogram PR prolongation 14.86 10.15 16 128489 1371 64368856
Oxygen consumption increased 14.83 10.15 30 128475 4551 64365676
Panic attack 14.79 10.15 12 128493 20941 64349286
Neutrophil count increased 14.77 10.15 17 128488 25157 64345070
Basal ganglia haemorrhage 14.68 10.15 16 128489 1390 64368837
Impaired work ability 14.60 10.15 6 128499 15213 64355014
Adrenal insufficiency 14.52 10.15 14 128491 22473 64347754
Superinfection 14.47 10.15 27 128478 3859 64366368
Vomiting 14.44 10.15 1280 127225 549837 63820390
Death 14.37 10.15 1132 127373 481573 63888654
Inflammation 14.36 10.15 74 128431 65226 64305001
Sedation 14.34 10.15 39 128466 41423 64328804
Hallucination 14.31 10.15 214 128291 72574 64297653
Limited symptom panic attack 14.30 10.15 5 128500 49 64370178
Haematotoxicity 14.26 10.15 4 128501 12892 64357335
Encephalomalacia 14.25 10.15 14 128491 1077 64369150
Gastric ulcer 14.15 10.15 106 128399 30128 64340099
Therapeutic response increased 14.13 10.15 10 128495 486 64369741
Cystitis 14.13 10.15 41 128464 42634 64327593
Blood bilirubin increased 14.09 10.15 176 128329 57377 64312850
Subdural haemorrhage 14.03 10.15 32 128473 5271 64364956
Proteinuria 13.93 10.15 21 128484 27702 64342525
Deep vein thrombosis 13.93 10.15 138 128367 105044 64265183
Dissociation 13.91 10.15 23 128482 2988 64367239
Injection site rash 13.87 10.15 7 128498 15735 64354492
Hypoglycaemic coma 13.85 10.15 28 128477 4246 64365981
Muscle spasticity 13.83 10.15 8 128497 16661 64353566
Enzyme induction 13.82 10.15 6 128499 109 64370118
Haemodialysis 13.82 10.15 69 128436 17008 64353219
Ecchymosis 13.81 10.15 60 128445 13962 64356265
Posthaemorrhagic hydrocephalus 13.76 10.15 4 128501 20 64370207
Intracardiac thrombus 13.74 10.15 26 128479 3755 64366472
Rhinorrhoea 13.73 10.15 67 128438 59902 64310325
Hypochromasia 13.68 10.15 11 128494 649 64369578
Respiratory acidosis 13.66 10.15 47 128458 9808 64360419
Coronary arterial stent insertion 13.59 10.15 33 128472 5659 64364568
Vision blurred 13.52 10.15 254 128251 90062 64280165
Pregnancy 13.46 10.15 13 128492 20852 64349375
Circulatory collapse 13.46 10.15 114 128391 33618 64336609
Lung transplant 13.41 10.15 27 128478 4081 64366146
Sudden death 13.40 10.15 77 128428 20019 64350208
Stupor 13.37 10.15 34 128471 6001 64364226
Azotaemia 13.35 10.15 39 128466 7463 64362764
Transplant evaluation 13.35 10.15 16 128489 1541 64368686
Mitral valve disease 13.35 10.15 21 128484 2617 64367610
Polyneuropathy 13.30 10.15 12 128493 19882 64350345
Hepatic steatosis 13.28 10.15 26 128479 30981 64339246
Pulse pressure decreased 13.27 10.15 9 128496 408 64369819
Injection site urticaria 13.26 10.15 3 128502 11178 64359049
Gastrooesophageal reflux disease 13.26 10.15 104 128401 83039 64287188
Aortic valve calcification 13.25 10.15 11 128494 679 64369548
Oesophageal achalasia 13.25 10.15 11 128494 679 64369548
Schizophrenia 13.24 10.15 3 128502 11165 64359062
Product storage error 13.19 10.15 5 128500 13313 64356914
Multiple sclerosis 13.18 10.15 11 128494 18930 64351297
Infective exacerbation of chronic obstructive airways disease 13.16 10.15 20 128485 2418 64367809
Metastases to lung 13.13 10.15 7 128498 15257 64354970
Dizziness postural 13.08 10.15 46 128459 9706 64360521
Dyschromatopsia 13.03 10.15 11 128494 695 64369532
Cardiac pacemaker insertion 12.95 10.15 30 128475 4993 64365234
Walking distance test abnormal 12.87 10.15 11 128494 707 64369520
Right ventricular systolic pressure increased 12.86 10.15 12 128493 866 64369361
International normalised ratio fluctuation 12.86 10.15 22 128483 2939 64367288
Iron deficiency anaemia 12.77 10.15 81 128424 21808 64348419
Pulmonary embolism 12.69 10.15 210 128295 146146 64224081
Bundle branch block 12.68 10.15 15 128490 1425 64368802
Cytomegalovirus viraemia 12.66 10.15 3 128502 10825 64359402
Accidental overdose 12.65 10.15 112 128393 33445 64336782
Muscular weakness 12.65 10.15 178 128327 127160 64243067
Vascular graft 12.61 10.15 17 128488 1842 64368385
Withdrawal syndrome 12.59 10.15 17 128488 23475 64346752
Rhinitis 12.55 10.15 3 128502 10762 64359465
Haemorrhagic stroke 12.54 10.15 46 128459 9905 64360322
Hemiparesis 12.54 10.15 102 128403 29725 64340502
Drug eruption 12.49 10.15 34 128471 36102 64334125
Ear infection 12.48 10.15 17 128488 23387 64346840
Catheterisation cardiac 12.44 10.15 29 128476 4844 64365383
Thrombotic microangiopathy 12.44 10.15 9 128496 16646 64353581
Seizure 12.41 10.15 246 128259 166646 64203581
Anticoagulation drug level above therapeutic 12.41 10.15 22 128483 3023 64367204
Hereditary haemorrhagic telangiectasia 12.38 10.15 4 128501 30 64370197
Morning glory syndrome 12.38 10.15 3 128502 6 64370221
Mesenteric artery embolism 12.27 10.15 5 128500 77 64370150
Blood pressure immeasurable 12.27 10.15 17 128488 1891 64368336
Choroidal haemorrhage 12.18 10.15 6 128499 147 64370080
Spinal pain 12.07 10.15 5 128500 12616 64357611
Blood alkaline phosphatase increased 12.07 10.15 168 128337 56111 64314116
Glaucoma 12.00 10.15 9 128496 16339 64353888
Lower limb fracture 11.97 10.15 6 128499 13539 64356688
Polypectomy 11.89 10.15 12 128493 954 64369273
Cardiopulmonary failure 11.88 10.15 33 128472 6137 64364090
Sedation complication 11.85 10.15 3 128502 10351 64359876
Wheezing 11.84 10.15 103 128402 80476 64289751
Brain stem haemorrhage 11.79 10.15 15 128490 1536 64368691
Acute myeloid leukaemia 11.79 10.15 23 128482 27440 64342787
Depressed mood 11.77 10.15 42 128463 40970 64329257
Drug ineffective for unapproved indication 11.76 10.15 28 128477 31105 64339122
Poor venous access 11.75 10.15 5 128500 12412 64357815
Protein total 11.74 10.15 4 128501 36 64370191
Musculoskeletal disorder 11.74 10.15 11 128494 17895 64352332
Second primary malignancy 11.62 10.15 5 128500 12332 64357895
Systolic dysfunction 11.62 10.15 22 128483 3180 64367047
Ventricular hypokinesia 11.61 10.15 38 128467 7731 64362496
Arteriovenous malformation 11.60 10.15 15 128490 1561 64368666
Mitral valve sclerosis 11.52 10.15 7 128498 262 64369965
Subcutaneous haematoma 11.52 10.15 19 128486 2464 64367763
Catheter site infection 11.51 10.15 31 128474 5662 64364565
Creatinine renal clearance decreased 11.48 10.15 58 128447 14363 64355864
Rhythm idioventricular 11.45 10.15 9 128496 514 64369713
Blood sodium decreased 11.43 10.15 99 128406 29383 64340844
Liver function test abnormal 11.42 10.15 174 128331 59227 64311000
Colour blindness 11.41 10.15 8 128497 383 64369844
Pulseless electrical activity 11.41 10.15 53 128452 12686 64357541
Ischaemic hepatitis 11.40 10.15 22 128483 3224 64367003
Retroperitoneal haemorrhage 11.39 10.15 28 128477 4840 64365387
Dry mouth 11.38 10.15 72 128433 60346 64309881
Device related sepsis 11.37 10.15 29 128476 5126 64365101
Disability 11.36 10.15 5 128500 12167 64358060
Heart disease congenital 11.34 10.15 9 128496 521 64369706
Peripheral artery stenosis 11.33 10.15 13 128492 1196 64369031
Bone marrow failure 11.32 10.15 53 128452 47899 64322328
Electrocardiogram R on T phenomenon 11.28 10.15 3 128502 10 64370217
Therapy interrupted 11.25 10.15 14 128491 20022 64350205
Cerebral atrophy 11.22 10.15 36 128469 7249 64362978
Intestinal obstruction 11.20 10.15 36 128469 36250 64333977
Microcytic anaemia 11.19 10.15 27 128478 4611 64365616
Skin disorder 11.19 10.15 24 128481 27656 64342571
Injury 11.15 10.15 165 128340 55827 64314400
Spinal stenosis 11.12 10.15 7 128498 13924 64356303
Electrocardiogram ST-T segment depression 11.06 10.15 3 128502 11 64370216
Prothrombin level increased 11.00 10.15 8 128497 406 64369821
Aphthous ulcer 10.98 10.15 6 128499 12900 64357327
Emotional distress 10.98 10.15 115 128390 35923 64334304
Intraventricular haemorrhage 10.92 10.15 25 128480 4128 64366099
Paracentesis 10.90 10.15 13 128492 1246 64368981
Body temperature increased 10.89 10.15 37 128468 36629 64333598
Mouth ulceration 10.86 10.15 31 128474 32413 64337814
Electrocardiogram ambulatory abnormal 10.86 10.15 3 128502 12 64370215
Central nervous system lesion 10.85 10.15 5 128500 11844 64358383
Procedural pain 10.80 10.15 9 128496 15499 64354728
Conjunctivitis 10.64 10.15 15 128490 20339 64349888
Appendicitis 10.58 10.15 7 128498 13562 64356665
Mental status changes 10.57 10.15 176 128329 60986 64309241
Gastric ulcer haemorrhage 10.57 10.15 38 128467 8105 64362122
Sciatica 10.52 10.15 15 128490 20249 64349978
Wrong technique in product usage process 10.48 10.15 81 128424 64893 64305334
Halo vision 10.43 10.15 9 128496 586 64369641
Catheter site erythema 10.41 10.15 27 128478 4822 64365405
Right ventricular dysfunction 10.41 10.15 17 128488 2186 64368041
Balloon atrial septostomy 10.36 10.15 5 128500 117 64370110
Hyponatraemic syndrome 10.36 10.15 10 128495 753 64369474
Abscess 10.32 10.15 14 128491 19290 64350937
Hypoglycaemic seizure 10.30 10.15 10 128495 758 64369469
Electrocardiogram change 10.28 10.15 12 128493 1124 64369103
Chorea 10.23 10.15 16 128489 1984 64368243

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
ATC C01AA05 CARDIOVASCULAR SYSTEM
CARDIAC THERAPY
CARDIAC GLYCOSIDES
Digitalis glycosides
FDA CS M0003451 Cardiac Glycosides
FDA EPC N0000175568 Cardiac Glycoside
CHEBI has role CHEBI:38070 antiarrhythmic agent
CHEBI has role CHEBI:38147 cardiotonic drugs
CHEBI has role CHEBI:53000 epitope role
CHEBI has role CHEBI:63510 sodium-potassium adenosine triphosphatase inhibitors
MeSH PA D000889 Anti-Arrhythmia Agents
MeSH PA D002316 Cardiotonic Agents
MeSH PA D002317 Cardiovascular Agents
MeSH PA D004791 Enzyme Inhibitors
MeSH PA D020011 Protective Agents

Drug Use (View source of the data)

DiseaseRelationSNOMED_IDDOID
Poisoning by digitalis glycoside indication 12876009
Chronic heart failure indication 48447003
Atrial fibrillation indication 49436004 DOID:0060224
Senile cardiac amyloidosis contraindication 16573007
Myocardial infarction contraindication 22298006 DOID:5844
Sick sinus syndrome contraindication 36083008 DOID:13884
Myxedema contraindication 43153006 DOID:11634
Hypokalemia contraindication 43339004
Sinus bradycardia contraindication 49710005
Myocarditis contraindication 50920009 DOID:820
Acute nephropathy contraindication 58574008
Hypercalcemia contraindication 66931009 DOID:12678
Ventricular fibrillation contraindication 71908006
Wolff-Parkinson-White pattern contraindication 74390002 DOID:384
Cor pulmonale contraindication 83291003 DOID:8515
Constrictive pericarditis contraindication 85598007 DOID:11481
Kidney disease contraindication 90708001 DOID:557
Hypomagnesemia contraindication 190855004
Atrioventricular block contraindication 233917008 DOID:0050820
Idiopathic hypertrophic subaortic stenosis contraindication 360465008
Restrictive cardiomyopathy contraindication 415295002 DOID:397




๐Ÿถ Veterinary Drug Use

None

๐Ÿถ Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

None

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

Formulation strengthTrade nameApplicantApplication numberApproval dateTypeDose formRouteExclusivity dateDescription
0.0625MG DIGOXIN AUROBINDO PHARMA LTD A214982 Feb. 8, 2022 RX TABLET ORAL Aug. 16, 2022 COMPETITIVE GENERIC THERAPY

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
Sodium/potassium-transporting ATPase Transporter INHIBITOR IC50 6.40 CHEMBL CHEMBL
Potassium voltage-gated channel subfamily H member 2 Ion channel IC50 4.14 WOMBAT-PK
Nuclear receptor ROR-gamma Nuclear hormone receptor IC50 5.70 CHEMBL
Signal transducer and activator of transcription 3 Transcription factor IC50 5.73 CHEMBL
Sodium/potassium-transporting ATPase subunit alpha-2 Ion channel IC50 5.78 DRUG MATRIX
Nuclear receptor ROR-gamma Nuclear hormone receptor IC50 5.70 CHEMBL
Sodium/potassium-transporting ATPase subunit alpha-1 Transporter IC50 6.30 CHEMBL

External reference:

IDSource
4018047 VUID
N0000146388 NUI
D00298 KEGG_DRUG
3407 RXNORM
4018047 VANDF
C0012265 UMLSCUI
CHEBI:4551 CHEBI
DGX PDB_CHEM_ID
CHEMBL1751 ChEMBL_ID
D004077 MESH_DESCRIPTOR_UI
DB00390 DRUGBANK_ID
4726 IUPHAR_LIGAND_ID
389 INN_ID
73K4184T59 UNII
2724385 PUBCHEM_CID
1413 MMSL
4597 MMSL
d00210 MMSL
000593 NDDF
387461009 SNOMEDCT_US
796001 SNOMEDCT_US

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
Digoxin HUMAN PRESCRIPTION DRUG LABEL 1 0054-0057 SOLUTION 0.05 mg ORAL NDA 27 sections
Digoxin HUMAN PRESCRIPTION DRUG LABEL 1 0115-9811 TABLET 125 ug ORAL ANDA 26 sections
Digoxin HUMAN PRESCRIPTION DRUG LABEL 1 0115-9822 TABLET 250 ug ORAL ANDA 26 sections
Digoxin HUMAN PRESCRIPTION DRUG LABEL 1 0143-1240 TABLET 125 ug ORAL ANDA 26 sections
Digoxin HUMAN PRESCRIPTION DRUG LABEL 1 0143-1241 TABLET 250 ug ORAL ANDA 26 sections
DIGITEK HUMAN PRESCRIPTION DRUG LABEL 1 0378-6155 TABLET 0.13 mg ORAL ANDA 26 sections
DIGITEK HUMAN PRESCRIPTION DRUG LABEL 1 0378-6156 TABLET 0.25 mg ORAL ANDA 26 sections
Digoxin HUMAN PRESCRIPTION DRUG LABEL 1 0404-9850 INJECTION 0.25 mg INTRAVENOUS ANDA 16 sections
DIGOX HUMAN PRESCRIPTION DRUG LABEL 1 0527-1324 TABLET 125 ug ORAL ANDA 22 sections
DIGOX HUMAN PRESCRIPTION DRUG LABEL 1 0527-1325 TABLET 250 ug ORAL ANDA 22 sections
Digoxin HUMAN PRESCRIPTION DRUG LABEL 1 0615-0547 TABLET 0.13 mg ORAL ANDA 12 sections
Digoxin HUMAN PRESCRIPTION DRUG LABEL 1 0615-8202 TABLET 125 ug ORAL ANDA 27 sections
Digoxin HUMAN PRESCRIPTION DRUG LABEL 1 0641-1410 INJECTION 0.25 mg INTRAMUSCULAR ANDA 26 sections
Digoxin HUMAN PRESCRIPTION DRUG LABEL 1 0641-1410 INJECTION 0.25 mg INTRAMUSCULAR ANDA 26 sections
Digoxin HUMAN PRESCRIPTION DRUG LABEL 1 0641-6184 INJECTION 0.25 mg INTRAMUSCULAR ANDA 26 sections
Digoxin HUMAN PRESCRIPTION DRUG LABEL 1 0641-6184 INJECTION 0.25 mg INTRAMUSCULAR ANDA 26 sections
Digoxin HUMAN PRESCRIPTION DRUG LABEL 1 0781-3059 INJECTION, SOLUTION 250 ug INTRAMUSCULAR ANDA 26 sections
Digoxin HUMAN PRESCRIPTION DRUG LABEL 1 0781-3059 INJECTION, SOLUTION 250 ug INTRAMUSCULAR ANDA 26 sections
Digoxin HUMAN PRESCRIPTION DRUG LABEL 1 0904-5921 TABLET 125 ug ORAL ANDA 26 sections
Digoxin HUMAN PRESCRIPTION DRUG LABEL 1 0904-5922 TABLET 250 ug ORAL ANDA 26 sections
Digoxin HUMAN PRESCRIPTION DRUG LABEL 1 10135-747 TABLET 0.13 mg ORAL ANDA 27 sections
Digoxin HUMAN PRESCRIPTION DRUG LABEL 1 10135-748 TABLET 0.25 mg ORAL ANDA 27 sections
Digoxin HUMAN PRESCRIPTION DRUG LABEL 1 16714-590 TABLET 125 ug ORAL ANDA 25 sections
Digoxin HUMAN PRESCRIPTION DRUG LABEL 1 16714-591 TABLET 250 ug ORAL ANDA 25 sections
Digoxin HUMAN PRESCRIPTION DRUG LABEL 1 17856-0057 SOLUTION 0.05 mg ORAL NDA 25 sections
Digoxin HUMAN PRESCRIPTION DRUG LABEL 1 21695-678 TABLET 0.13 mg ORAL ANDA 17 sections
LANOXIN HUMAN PRESCRIPTION DRUG LABEL 1 24987-262 INJECTION, SOLUTION 100 ug INTRAMUSCULAR NDA 24 sections
DIGITEK HUMAN PRESCRIPTION DRUG LABEL 1 42292-002 TABLET 0.25 mg ORAL ANDA 26 sections
DIGITEK HUMAN PRESCRIPTION DRUG LABEL 1 42292-003 TABLET 0.13 mg ORAL ANDA 26 sections
Digoxin HUMAN PRESCRIPTION DRUG LABEL 1 50090-4432 TABLET 125 ug ORAL ANDA 28 sections