deslanoside Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
813 17598-65-1

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • deslanoside
  • Cedilanid D
  • Deacetylanatoside C
  • Deacetyllanatoside C
  • desace
  • Desacetyllanatoside C
  • Deslanatoside C
  • Deslanoside C
  • Purpurea glycoside C
Deacetyllanatoside C. A cardiotonic glycoside from the leaves of Digitalis lanata.
  • Molecular weight: 943.09
  • Formula: C47H74O19
  • CLOGP: 0.32
  • LIPINSKI: 3
  • HAC: 19
  • HDO: 9
  • TPSA: 282.21
  • ALOGS: -3.30
  • ROTB: 10

  • Status: OFM

  • Legend:
    OFP - off patent
    OFM - off market
    ONP - on patent

Drug dosage:

DoseUnitRoute
1 mg P

ADMET properties:

PropertyValueReference
MRTD (Maximum Recommended Therapeutic Daily Dose) 0.02 ┬ÁM/kg/day Contrera JF, Matthews EJ, Kruhlak NL, Benz RD

Approvals:

DateAgencyCompanyOrphan
None FDA NOVARTIS

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

None

Pharmacologic Action:

SourceCodeDescription
ATC C01AA07 CARDIOVASCULAR SYSTEM
CARDIAC THERAPY
CARDIAC GLYCOSIDES
Digitalis glycosides
MeSH PA D000889 Anti-Arrhythmia Agents
MeSH PA D002316 Cardiotonic Agents
MeSH PA D002317 Cardiovascular Agents
MeSH PA D004791 Enzyme Inhibitors
MeSH PA D020011 Protective Agents
CHEBI has role CHEBI:25212 metabolites
CHEBI has role CHEBI:38070 antiarrhythmic agent
CHEBI has role CHEBI:38147 cardiotonic drugs
CHEBI has role CHEBI:63510 na(+)/k(+)-pump inhibitors

Drug Use (View source of the data)

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 13.68 acidic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
Sodium/potassium-transporting ATPase Transporter INHIBITOR CHEMBL CHEMBL

External reference:

IDSource
4018753 VUID
N0000147056 NUI
D01240 KEGG_DRUG
4018753 VANDF
C0917881 UMLSCUI
CHEBI:31468 CHEBI
CHEMBL1614 ChEMBL_ID
DB01078 DRUGBANK_ID
D003892 MESH_DESCRIPTOR_UI
28620 PUBCHEM_CID
6806 IUPHAR_LIGAND_ID
1581 INN_ID
YGY317RK75 UNII
3248 RXNORM
000595 NDDF
16214005 SNOMEDCT_US
398962006 SNOMEDCT_US

Pharmaceutical products:

None