deslanoside 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | PK/Tox | Related Drugs | BioActivity |

Stem definitionDrug idCAS RN
813 17598-65-1

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • deslanoside
  • Cedilanid D
  • Deacetylanatoside C
  • Deacetyllanatoside C
  • desace
  • Desacetyllanatoside C
  • Deslanatoside C
  • Deslanoside C
  • Purpurea glycoside C
Deacetyllanatoside C. A cardiotonic glycoside from the leaves of Digitalis lanata.
  • Molecular weight: 943.09
  • Formula: C47H74O19
  • CLOGP: 0.32
  • LIPINSKI: 3
  • HAC: 19
  • HDO: 9
  • TPSA: 282.21
  • ALOGS: -3.30
  • ROTB: 10
  • Status: OFM
    • Legend:
    OFP - off patent
    OFM - off market
    ONP - on patent

Drug dosage:

DoseUnitRoute
1 mg P

ADMET properties:

PropertyValueReference
MRTD (Maximum Recommended Therapeutic Daily Dose) 0.02 µM/kg/day Contrera JF, Matthews EJ, Kruhlak NL, Benz RD

Predicted pharmacokinetic/toxicological properties (PK-AZ):

PropertyDescriptionValueUnitConfidenceSimilarity
azlogd74 LogD at pH 7.4 0.466 Moderate 0.75
caco2-efflux Caco-2 efflux ratio (BA/AB) 20.184 Moderate 0.75
caco2-intrinsic-papp Caco-2 intrinsic apparent permeability 1.384 10^-6 cm/s Moderate 0.75
dh-clint Dog hepatocyte intrinsic clearance 1.413 uL/min/10^6 cells Moderate 0.75
dppb Dog plasma protein binding (% unbound) 71.710 % Moderate 0.75
fcs-ppb Fetal calf serum protein binding (% unbound) 60.930 % Moderate 0.75
herg hERG pIC50 4.288 pIC50 Moderate 0.75
hh-clint Human hepatocyte intrinsic clearance 0.910 uL/min/10^6 cells Moderate 0.75
hlm-clint Human liver microsomal intrinsic clearance 3.148 uL/min/mg protein Moderate 0.75
hppb Human plasma protein binding (% unbound) 70.720 % Moderate 0.75
kinase-safety-class ACVR2B,CAMK2D,CDK5,EIF2AK3,GRK2,ITK,MAP2K6,MAP3K21,MAPK10,NTRK2,PDK1,PDK2,PDK4,PRKDC,TEK 15
mdck-mdr1-bcrp-efflux MDCK-MDR1-BCRP efflux ratio 1.340 High 0.83
mdck-mdr1-efflux MDCK-MDR1 efflux ratio 7.112 Moderate 0.75
mh-clint Mouse hepatocyte intrinsic clearance 2.028 Moderate 0.75
mppb Mouse plasma protein binding (% unbound) 59.330 Moderate 0.75
nih-mdck-mdr1-efflux NIH MDCK-MDR1 efflux ratio 9.290 Moderate 0.75
pfas-class PFAS structural alert (1 = True, 0 = False) 0
pld-class Phospholipidosis risk class (1 = positive, 0 = negative) 1 High 0.83
pppb Pig plasma protein binding (% unbound) 67.020 % Moderate 0.75
rat-kpuu-brain Rat brain Kpuu 0.008 % High 0.83
rh-clint Rat hepatocyte intrinsic clearance 1.089 uL/min/10^6 cells Moderate 0.75
rh-fuinc Rat hepatocyte fraction unbound in incubation 84.420 % Moderate 0.75
rppb Rat plasma protein binding (% unbound) 61.910 % Moderate 0.75
solubility-dd Solubility at pH 7.4 in DMSO 879.023 uM Moderate 0.75

Approvals:

DateAgencyCompanyOrphan
None FDA NOVARTIS

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

None

FDA Adverse Event Reporting System (Geriatric)

None

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
ATC C01AA07 CARDIOVASCULAR SYSTEM
CARDIAC THERAPY
CARDIAC GLYCOSIDES
Digitalis glycosides
MeSH PA D000889 Anti-Arrhythmia Agents
MeSH PA D002316 Cardiotonic Agents
MeSH PA D002317 Cardiovascular Agents
MeSH PA D004791 Enzyme Inhibitors
MeSH PA D020011 Protective Agents
CHEBI has role CHEBI:25212 metabolite
CHEBI has role CHEBI:38070 anti-arrhythmia drug
CHEBI has role CHEBI:38147 cardiotonic drug
CHEBI has role CHEBI:63510 EC 3.6.3.9 (<em>Na</em><small><sup>+</small></sup>/<em>K</em><small><sup>+</small></sup>-transporting ATPase) inhibitor

Related Drugs by ATC class:

C01AA Digitalis glycosides 7 drugs
acetyldigitoxinacetyldigoxindigitoxindigoxingitoformatelanatoside Cmetildigoxin

Drug Use | Suggest Off label Use Form| |View source of the data|

None




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 13.68 acidic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])		Mechanism
action		Bioact sourceMoA source
Sodium/potassium-transporting ATPase Transporter INHIBITOR CHEMBL CHEMBL

External reference:

IDSource
4018753 VUID
N0000147056 NUI
D01240 KEGG_DRUG
3248 RXNORM
4018753 VANDF
C0011689 UMLSCUI
CHEBI:31468 CHEBI
CHEMBL1614 ChEMBL_ID
D003892 MESH_DESCRIPTOR_UI
DB01078 DRUGBANK_ID
6806 IUPHAR_LIGAND_ID
1581 INN_ID
YGY317RK75 UNII
28620 PUBCHEM_CID
000595 NDDF
16214005 SNOMEDCT_US
398962006 SNOMEDCT_US

Pharmaceutical products:

None