deslanoside 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definition	Drug id	CAS RN
	813	17598-65-1

Description:

Molecule

Description

Molfile Inchi Smiles

Synonyms:

deslanoside
Cedilanid D
Deacetylanatoside C
Deacetyllanatoside C
desace
Desacetyllanatoside C
Deslanatoside C
Deslanoside C
Purpurea glycoside C

Deacetyllanatoside C. A cardiotonic glycoside from the leaves of Digitalis lanata.

Molecular weight: 943.09
Formula: C47H74O19
CLOGP: 0.32
LIPINSKI: 3
HAC: 19
HDO: 9
TPSA: 282.21
ALOGS: -3.30
ROTB: 10

Status: OFM

Legend:
OFP - off patent
OFM - off market
ONP - on patent

Drug dosage:

Dose	Unit	Route
1	mg	P

ADMET properties:

Property	Value	Reference
MRTD (Maximum Recommended Therapeutic Daily Dose)	0.02 µM/kg/day	Contrera JF, Matthews EJ, Kruhlak NL, Benz RD

Approvals:

Date	Agency	Company	Orphan
None	FDA	NOVARTIS

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

None

FDA Adverse Event Reporting System (Geriatric)

None

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

Source	Code	Description
ATC	C01AA07	CARDIOVASCULAR SYSTEM CARDIAC THERAPY CARDIAC GLYCOSIDES Digitalis glycosides
MeSH PA	D000889	Anti-Arrhythmia Agents
MeSH PA	D002316	Cardiotonic Agents
MeSH PA	D002317	Cardiovascular Agents
MeSH PA	D004791	Enzyme Inhibitors
MeSH PA	D020011	Protective Agents
CHEBI has role	CHEBI:25212	metabolites
CHEBI has role	CHEBI:38070	antiarrhythmic agent
CHEBI has role	CHEBI:38147	cardiotonic drugs
CHEBI has role	CHEBI:63510	sodium-potassium adenosine triphosphatase inhibitors

Drug Use | Suggest Off label Use Form| |View source of the data|

None

🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation level	Dissociation constant	Type (acidic/basic)
pKa1	13.68	acidic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

Target	Class	Pharos	UniProt	Action	Type	Activity value (-log[M])	Mechanism action	Bioact source	MoA source
Sodium/potassium-transporting ATPase	Transporter	P05023 P05026 P13637 P14415 P50993 P54709 P54710 Q13733	AT1A1_HUMAN AT1B1_HUMAN AT1A3_HUMAN AT1B2_HUMAN AT1A2_HUMAN AT1B3_HUMAN ATNG_HUMAN AT1A4_HUMAN	INHIBITOR				CHEMBL	CHEMBL

External reference:

ID	Source
4018753	VUID
N0000147056	NUI
D01240	KEGG_DRUG
3248	RXNORM
4018753	VANDF
C0011689	UMLSCUI
CHEBI:31468	CHEBI
CHEMBL1614	ChEMBL_ID
D003892	MESH_DESCRIPTOR_UI
DB01078	DRUGBANK_ID
6806	IUPHAR_LIGAND_ID
1581	INN_ID
YGY317RK75	UNII
28620	PUBCHEM_CID
000595	NDDF
16214005	SNOMEDCT_US
398962006	SNOMEDCT_US

Pharmaceutical products:

None