deslanoside ๐Ÿถ Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
813 17598-65-1

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • deslanoside
  • Cedilanid D
  • Deacetylanatoside C
  • Deacetyllanatoside C
  • desace
  • Desacetyllanatoside C
  • Deslanatoside C
  • Deslanoside C
  • Purpurea glycoside C
Deacetyllanatoside C. A cardiotonic glycoside from the leaves of Digitalis lanata.
  • Molecular weight: 943.09
  • Formula: C47H74O19
  • CLOGP: 0.32
  • LIPINSKI: 3
  • HAC: 19
  • HDO: 9
  • TPSA: 282.21
  • ALOGS: -3.30
  • ROTB: 10

  • Status: OFM

  • Legend:
    OFP - off patent
    OFM - off market
    ONP - on patent

Drug dosage:

DoseUnitRoute
1 mg P

ADMET properties:

PropertyValueReference
MRTD (Maximum Recommended Therapeutic Daily Dose) 0.02 ยตM/kg/day Contrera JF, Matthews EJ, Kruhlak NL, Benz RD

Approvals:

DateAgencyCompanyOrphan
None FDA NOVARTIS

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

None

FDA Adverse Event Reporting System (Geriatric)

None

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
ATC C01AA07 CARDIOVASCULAR SYSTEM
CARDIAC THERAPY
CARDIAC GLYCOSIDES
Digitalis glycosides
MeSH PA D000889 Anti-Arrhythmia Agents
MeSH PA D002316 Cardiotonic Agents
MeSH PA D002317 Cardiovascular Agents
MeSH PA D004791 Enzyme Inhibitors
MeSH PA D020011 Protective Agents
CHEBI has role CHEBI:25212 metabolites
CHEBI has role CHEBI:38070 antiarrhythmic agent
CHEBI has role CHEBI:38147 cardiotonic drugs
CHEBI has role CHEBI:63510 sodium-potassium adenosine triphosphatase inhibitors

Drug Use (View source of the data)

None




๐Ÿถ Veterinary Drug Use

None

๐Ÿถ Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 13.68 acidic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
Sodium/potassium-transporting ATPase Transporter INHIBITOR CHEMBL CHEMBL

External reference:

IDSource
4018753 VUID
N0000147056 NUI
D01240 KEGG_DRUG
3248 RXNORM
4018753 VANDF
C0011689 UMLSCUI
CHEBI:31468 CHEBI
CHEMBL1614 ChEMBL_ID
D003892 MESH_DESCRIPTOR_UI
DB01078 DRUGBANK_ID
6806 IUPHAR_LIGAND_ID
1581 INN_ID
YGY317RK75 UNII
28620 PUBCHEM_CID
000595 NDDF
16214005 SNOMEDCT_US
398962006 SNOMEDCT_US

Pharmaceutical products:

None