acetyldigitoxin Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
67 1111-39-3

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • acetyldigitoxin
  • acylanid
  • Desglucolanatoside A
  • alpha-Acetyldigitoxin
Cardioactive derivatives of lanatoside A or of DIGITOXIN. They are used for fast digitalization in congestive heart failure.
  • Molecular weight: 806.99
  • Formula: C43H66O14
  • CLOGP: 3.46
  • LIPINSKI: 2
  • HAC: 14
  • HDO: 4
  • TPSA: 188.90
  • ALOGS: -4.82
  • ROTB: 9

  • Status: OFM

  • Legend:
    OFP - off patent
    OFM - off market
    ONP - on patent

Drug dosage:

DoseUnitRoute
0.20 mg O

ADMET properties:

PropertyValueReference
BA (Bioavailability) 70 % Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H

Approvals:

DateAgencyCompanyOrphan
April 24, 1975 FDA NOVARTIS

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

None

Pharmacologic Action:

SourceCodeDescription
ATC C01AA01 CARDIOVASCULAR SYSTEM
CARDIAC THERAPY
CARDIAC GLYCOSIDES
Digitalis glycosides
MeSH PA D000889 Anti-Arrhythmia Agents
MeSH PA D002316 Cardiotonic Agents
MeSH PA D002317 Cardiovascular Agents
MeSH PA D004791 Enzyme Inhibitors
MeSH PA D020011 Protective Agents
CHEBI has role CHEBI:23924 enzyme inhibitors
CHEBI has role CHEBI:38070 antiarrhythmic agent
CHEBI has role CHEBI:38147 cardiotonic drugs

Drug Use (View source of the data)

DiseaseRelationSNOMED_IDDOID
Congestive heart failure indication 42343007 DOID:6000
Atrial fibrillation indication 49436004 DOID:0060224

Acid dissociation constants calculated using MoKa v3.0.0

None

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
Sodium/potassium-transporting ATPase Transporter INHIBITOR CHEMBL CHEMBL

External reference:

IDSource
0ZV4Q4L2FU UNII
D06881 KEGG_DRUG
C0520442 UMLSCUI
CHEBI:53773 CHEBI
CHEMBL3545057 ChEMBL_ID
5284512 PUBCHEM_CID
DB00511 DRUGBANK_ID
D000112 MESH_DESCRIPTOR_UI
792 INN_ID
6794 IUPHAR_LIGAND_ID
132871 RXNORM
000596 NDDF
7834009 SNOMEDCT_US

Pharmaceutical products:

None