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acetyldigoxin 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | PK/Tox | Related Drugs | BioActivity |
| Stem definition | Drug id | CAS RN |
|---|---|---|
| 68 | 5355-48-6 |
Description:
| Molecule | Description |
|---|---|
|
Synonyms:
|
Alpha- or beta-acetyl derivatives of DIGOXIN or lanatoside C from Digitalis lanata. They are better absorbed and longer acting than digoxin and are used in congestive heart failure.
|
Drug dosage:
| Dose | Unit | Route |
|---|---|---|
| 0.50 | mg | O |
ADMET properties:
None
Predicted pharmacokinetic/toxicological properties (PK-AZ):
| Property | Description | Value | Unit | Confidence | Similarity |
|---|---|---|---|---|---|
| azlogd74 | LogD at pH 7.4 | 1.606 | High | 0.88 | |
| caco2-efflux | Caco-2 efflux ratio (BA/AB) | 22.646 | High | 0.88 | |
| herg | hERG pIC50 | 4.417 | pIC50 | High | 0.88 |
| caco2-intrinsic-papp | Caco-2 intrinsic apparent permeability | 11.324 | 10^-6 cm/s | High | 0.88 |
| dh-clint | Dog hepatocyte intrinsic clearance | 3.206 | uL/min/10^6 cells | High | 0.88 |
| dppb | Dog plasma protein binding (% unbound) | 47.180 | % | High | 0.88 |
| fcs-ppb | Fetal calf serum protein binding (% unbound) | 41.230 | % | High | 0.88 |
| hh-clint | Human hepatocyte intrinsic clearance | 1.706 | uL/min/10^6 cells | High | 0.88 |
| hlm-clint | Human liver microsomal intrinsic clearance | 5.794 | uL/min/mg protein | High | 0.88 |
| hppb | Human plasma protein binding (% unbound) | 49.710 | % | High | 0.88 |
| kinase-safety-class | ACVR2B,CDK5,EIF2AK3,GRK2,ITK,PDK1,PDK2,PRKDC | 8 | |||
| mdck-mdr1-bcrp-efflux | MDCK-MDR1-BCRP efflux ratio | 9.550 | High | 0.84 | |
| mdck-mdr1-efflux | MDCK-MDR1 efflux ratio | 27.040 | High | 0.88 | |
| mh-clint | Mouse hepatocyte intrinsic clearance | 7.079 | High | 0.88 | |
| mppb | Mouse plasma protein binding (% unbound) | 34.110 | High | 0.88 | |
| nih-mdck-mdr1-efflux | NIH MDCK-MDR1 efflux ratio | 39.537 | High | 0.88 | |
| pfas-class | PFAS structural alert (1 = True, 0 = False) | 0 | |||
| pld-class | Phospholipidosis risk class (1 = positive, 0 = negative) | 1 | High | 0.84 | |
| pppb | Pig plasma protein binding (% unbound) | 43.080 | % | High | 0.88 |
| rat-kpuu-brain | Rat brain Kpuu | 0.011 | % | High | 0.84 |
| rh-clint | Rat hepatocyte intrinsic clearance | 3.281 | uL/min/10^6 cells | High | 0.88 |
| rh-fuinc | Rat hepatocyte fraction unbound in incubation | 71.570 | % | High | 0.88 |
| rppb | Rat plasma protein binding (% unbound) | 41.060 | % | High | 0.88 |
| solubility-dd | Solubility at pH 7.4 in DMSO | 770.903 | uM | High | 0.88 |
Approvals:
None
FDA Adverse Event Reporting System (Female)
None
FDA Adverse Event Reporting System (Male)
None
FDA Adverse Event Reporting System (Geriatric)
None
FDA Adverse Event Reporting System (Pediatric)
None
Pharmacologic Action:
| Source | Code | Description |
|---|---|---|
| ATC | C01AA02 | CARDIOVASCULAR SYSTEM CARDIAC THERAPY CARDIAC GLYCOSIDES Digitalis glycosides |
| ATC | C01AA52 | CARDIOVASCULAR SYSTEM CARDIAC THERAPY CARDIAC GLYCOSIDES Digitalis glycosides |
| MeSH PA | D000889 | Anti-Arrhythmia Agents |
| MeSH PA | D002316 | Cardiotonic Agents |
| MeSH PA | D002317 | Cardiovascular Agents |
| MeSH PA | D004791 | Enzyme Inhibitors |
| MeSH PA | D020011 | Protective Agents |
Related Drugs by ATC class:
C01AA Digitalis glycosides 7 drugs
Drug Use | Suggest Off label Use Form| |View source of the data|
None
🐶 Veterinary Drug Use
None
🐶 Veterinary products
None
Acid dissociation constants calculated using MoKa v3.0.0
None
Orange Book patent data (new drug applications)
None
Orange Book exclusivity data (new drug applications)
None
Bioactivity Summary:
None
External reference:
| ID | Source |
|---|---|
| N0000168451 | NUI |
| 199 | RXNORM |
| C0001050 | UMLSCUI |
| CHEMBL2074725 | ChEMBL_ID |
| DB13691 | DRUGBANK_ID |
| 11765960 | PUBCHEM_CID |
| D000113 | MESH_DESCRIPTOR_UI |
| CHEBI:135892 | CHEBI |
| P7K44M64CW | UNII |
| 007426 | NDDF |
Pharmaceutical products:
None