fludarabine phosphate Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
arabinofuranosyl derivatives 1189 75607-67-9

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • fludarabine 5'-monophosphate
  • fludarabine phosphate
  • fludura
  • fludara
  • 2-F-ara-AMP
  • Molecular weight: 365.21
  • Formula: C10H13FN5O7P
  • CLOGP: -3.93
  • LIPINSKI: 1
  • HAC: 12
  • HDO: 5
  • TPSA: 186.07
  • ALOGS: -2.09
  • ROTB: 4

  • Status: OFP

  • Legend:
    OFP - off patent
    OFM - off market
    ONP - on patent

Drug dosage:

None

ADMET properties:

PropertyValueReference
BDDCS (Biopharmaceutical Drug Disposition Classification System) 1 Benet LZ, Broccatelli F, Oprea TI
S (Water solubility) 3.53 mg/mL Benet LZ, Broccatelli F, Oprea TI
MRTD (Maximum Recommended Therapeutic Daily Dose) 2.66 µM/kg/day Contrera JF, Matthews EJ, Kruhlak NL, Benz RD
BA (Bioavailability) 57.50 % Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H

Approvals:

DateAgencyCompanyOrphan
April 18, 1991 FDA

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Acute graft versus host disease 1398.03 21.99 354 29101 3676 46652931
Cytokine release syndrome 1155.90 21.99 334 29121 5889 46650718
Cytomegalovirus infection 888.01 21.99 358 29097 17786 46638821
Graft versus host disease 804.09 21.99 256 29199 6332 46650275
Chronic graft versus host disease 753.67 21.99 200 29255 2525 46654082
Acute graft versus host disease in skin 740.49 21.99 201 29254 2781 46653826
Febrile neutropenia 712.84 21.99 540 28915 94087 46562520
Adenovirus infection 543.54 21.99 156 29299 2674 46653933
Graft versus host disease in skin 506.61 21.99 142 29313 2225 46654382
Graft versus host disease in gastrointestinal tract 434.08 21.99 128 29327 2422 46654185
Human herpesvirus 6 infection 404.56 21.99 120 29335 2319 46654288
Acute graft versus host disease in intestine 382.47 21.99 106 29349 1589 46655018
Venoocclusive liver disease 381.37 21.99 131 29324 4120 46652487
Product use in unapproved indication 379.11 21.99 369 29086 89904 46566703
Hypogammaglobulinaemia 349.86 21.99 131 29324 5307 46651300
Cytomegalovirus viraemia 344.22 21.99 123 29332 4355 46652252
Neurotoxicity 339.36 21.99 168 29287 13549 46643058
Myelodysplastic syndrome 334.93 21.99 174 29281 15537 46641070
Thrombotic microangiopathy 332.08 21.99 142 29313 8164 46648443
Acute myeloid leukaemia 325.66 21.99 171 29284 15607 46641000
Pyrexia 315.45 21.99 684 28771 348118 46308489
Progressive multifocal leukoencephalopathy 313.86 21.99 150 29305 11196 46645411
Neutropenia 297.65 21.99 407 29048 142797 46513810
Epstein-Barr virus infection 294.58 21.99 123 29332 6661 46649946
Acute lymphocytic leukaemia recurrent 282.91 21.99 88 29367 2007 46654600
Acute myeloid leukaemia recurrent 259.31 21.99 75 29380 1321 46655286
Premature menopause 258.96 21.99 65 29390 646 46655961
Pancytopenia 247.13 21.99 286 29169 84772 46571835
Cytomegalovirus infection reactivation 242.26 21.99 72 29383 1400 46655207
Bronchopulmonary aspergillosis 241.05 21.99 110 29345 7386 46649221
Haemophagocytic lymphohistiocytosis 238.99 21.99 113 29342 8229 46648378
Cystitis haemorrhagic 237.48 21.99 88 29367 3459 46653148
BK virus infection 237.00 21.99 83 29372 2766 46653841
Encephalitis viral 222.33 21.99 69 29386 1561 46655046
Post transplant lymphoproliferative disorder 212.52 21.99 83 29372 3773 46652834
Multiple organ dysfunction syndrome 197.57 21.99 201 29254 51509 46605098
Thrombocytopenia 191.21 21.99 310 29145 126271 46530336
Viral haemorrhagic cystitis 183.84 21.99 48 29407 565 46656042
Cytomegalovirus test positive 181.60 21.99 68 29387 2752 46653855
Aspergillus infection 175.16 21.99 86 29369 6804 46649803
Viraemia 172.00 21.99 51 29404 983 46655624
Posterior reversible encephalopathy syndrome 170.98 21.99 111 29344 15030 46641577
Transplant failure 170.68 21.99 53 29402 1201 46655406
Mucosal inflammation 170.21 21.99 163 29292 38813 46617794
Pain 165.90 21.99 48 29407 476900 46179707
Immune effector cell-associated neurotoxicity syndrome 163.94 21.99 45 29410 649 46655958
Cytopenia 162.53 21.99 85 29370 7683 46648924
Bone marrow failure 152.66 21.99 136 29319 29533 46627074
Venoocclusive disease 143.81 21.99 52 29403 1904 46654703
Neutrophil count decreased 143.02 21.99 156 29299 43270 46613337
Lymphocyte count decreased 139.05 21.99 121 29334 25468 46631139
Acute graft versus host disease in liver 135.12 21.99 38 29417 602 46656005
Chronic graft versus host disease in skin 131.63 21.99 37 29418 585 46656022
Engraft failure 130.65 21.99 33 29422 337 46656270
Cytomegalovirus chorioretinitis 125.71 21.99 44 29411 1463 46655144
Epstein-Barr viraemia 125.42 21.99 37 29418 700 46655907
Pre-engraftment immune reaction 124.05 21.99 29 29426 207 46656400
Stem cell transplant 122.58 21.99 45 29410 1721 46654886
Fall 120.13 21.99 30 29425 329067 46327540
White blood cell count decreased 119.38 21.99 236 29219 111995 46544612
Platelet count decreased 113.28 21.99 216 29239 99808 46556799
Bacterial sepsis 107.33 21.99 50 29405 3517 46653090
Dizziness 106.39 21.99 41 29414 340373 46316234
Sepsis 105.75 21.99 252 29203 135762 46520845
Systemic mycosis 104.67 21.99 34 29421 895 46655712
Drug hypersensitivity 104.24 21.99 15 29440 243810 46412797
JC virus infection 99.50 21.99 38 29417 1624 46654983
Leukoencephalopathy 98.85 21.99 49 29406 3955 46652652
Diffuse large B-cell lymphoma 96.55 21.99 55 29400 5883 46650724
Second primary malignancy 96.48 21.99 57 29398 6527 46650080
Epstein-Barr virus associated lymphoproliferative disorder 92.81 21.99 35 29420 1444 46655163
B-cell type acute leukaemia 90.96 21.99 20 29435 104 46656503
Fatigue 88.39 21.99 156 29299 608541 46048066
Autoimmune haemolytic anaemia 87.38 21.99 46 29409 4212 46652395
Neoplasm recurrence 86.41 21.99 38 29417 2335 46654272
Headache 85.55 21.99 106 29349 478246 46178361
Adenoviral hepatitis 85.53 21.99 22 29433 243 46656364
Staphylococcal sepsis 84.48 21.99 55 29400 7477 46649130
Pain in extremity 84.41 21.99 29 29426 258651 46397956
Herpes simplex 84.10 21.99 54 29401 7169 46649438
Engraftment syndrome 83.94 21.99 22 29433 263 46656344
Chronic lymphocytic leukaemia 82.17 21.99 39 29416 2861 46653746
Encephalopathy 81.16 21.99 103 29352 33486 46623121
Growth failure 81.01 21.99 22 29433 304 46656303
Haematocrit decreased 80.78 21.99 105 29350 34952 46621655
Joint swelling 79.00 21.99 7 29448 166066 46490541
Bacteraemia 78.93 21.99 68 29387 14111 46642496
Anxiety 78.19 21.99 11 29444 181946 46474661
Nasopharyngitis 77.47 21.99 5 29450 153993 46502614
Fusarium infection 76.86 21.99 24 29431 554 46656053
Drug resistance 76.46 21.99 73 29382 17295 46639312
Heart rate abnormal 76.42 21.99 39 29416 3348 46653259
Blood follicle stimulating hormone increased 75.41 21.99 18 29437 142 46656465
Varicella zoster virus infection 74.10 21.99 34 29421 2309 46654298
Upper respiratory fungal infection 72.88 21.99 17 29438 120 46656487
Fungaemia 72.88 21.99 32 29423 1959 46654648
Rhinovirus infection 70.99 21.99 38 29417 3598 46653009
Chronic lymphocytic leukaemia recurrent 70.89 21.99 18 29437 188 46656419
Lymphadenitis 70.67 21.99 34 29421 2571 46654036
Meningoencephalitis herpetic 69.42 21.99 26 29429 1052 46655555
Pulmonary haemorrhage 69.30 21.99 46 29409 6459 46650148
Disseminated mucormycosis 69.09 21.99 16 29439 109 46656498
Septic shock 67.93 21.99 127 29328 57766 46598841
Alopecia 67.06 21.99 11 29444 162403 46494204
Pneumocystis jirovecii pneumonia 66.95 21.99 64 29391 15184 46641423
Nausea 66.56 21.99 218 29237 687236 45969371
Cystitis viral 66.13 21.99 15 29440 92 46656515
Arthralgia 65.92 21.99 80 29375 364523 46292084
Staphylococcal infection 65.65 21.99 96 29359 35675 46620932
Respiratory failure 65.50 21.99 168 29287 94648 46561959
Abdominal discomfort 65.25 21.99 9 29446 151156 46505451
Malaise 64.97 21.99 68 29387 331164 46325443
Malignant neoplasm progression 64.74 21.99 133 29322 64793 46591814
Peripheral swelling 64.61 21.99 11 29444 158060 46498547
Leukaemia recurrent 64.52 21.99 26 29429 1283 46655324
Depression 62.95 21.99 15 29440 170089 46486518
Enterococcal bacteraemia 62.62 21.99 25 29430 1204 46655403
Bone marrow transplant 61.45 21.99 21 29434 649 46655958
Dyspnoea 61.27 21.99 148 29307 515400 46141207
Lymphopenia 61.18 21.99 61 29394 15232 46641375
Pneumonia fungal 60.91 21.99 36 29419 4124 46652483
Pruritus 60.84 21.99 39 29416 242313 46414294
Pneumonia cytomegaloviral 60.60 21.99 28 29427 1932 46654675
Off label use 59.89 21.99 427 29028 379414 46277193
Fungal infection 59.73 21.99 83 29372 29437 46627170
Encephalitis 59.15 21.99 44 29411 7404 46649203
Aplasia 57.81 21.99 33 29422 3543 46653064
Condition aggravated 56.79 21.99 43 29412 245009 46411598
Minimal residual disease 55.65 21.99 12 29443 56 46656551
Feeling abnormal 55.03 21.99 7 29448 125053 46531554
Hypersensitivity 54.17 21.99 14 29441 150307 46506300
Infection 53.90 21.99 196 29259 133396 46523211
Hypoxia 53.82 21.99 108 29347 51730 46604877
Toxoplasmosis 52.96 21.99 23 29432 1371 46655236
Epstein-Barr virus infection reactivation 52.57 21.99 15 29440 251 46656356
Lymphadenopathy 51.76 21.99 83 29372 33405 46623202
Tumour lysis syndrome 51.40 21.99 40 29415 7196 46649411
Disease progression 51.31 21.99 150 29305 91150 46565457
Nodular melanoma 51.25 21.99 11 29444 50 46656557
Blood stem cell transplant failure 50.67 21.99 13 29442 142 46656465
Disseminated intravascular coagulation 50.26 21.99 61 29394 18944 46637663
Alternaria infection 50.02 21.99 13 29442 150 46656457
Acute respiratory distress syndrome 49.46 21.99 65 29390 21857 46634750
Muscle spasms 49.36 21.99 9 29446 123104 46533503
Urinary tract infection 49.32 21.99 40 29415 220226 46436381
Graft versus host disease in lung 49.19 21.99 15 29440 319 46656288
Diffuse large B-cell lymphoma recurrent 48.28 21.99 22 29433 1470 46655137
Constipation 47.96 21.99 25 29430 174072 46482535
Myelosuppression 47.10 21.99 39 29416 7664 46648943
Exposure during pregnancy 45.39 21.99 7 29448 108205 46548402
Drug interaction 45.32 21.99 37 29418 203057 46453550
Transplant dysfunction 44.84 21.99 31 29424 4651 46651956
Back pain 44.75 21.99 40 29415 209999 46446608
Refractory cytopenia with unilineage dysplasia 44.63 21.99 16 29439 571 46656036
Graft versus host disease in liver 44.54 21.99 15 29440 443 46656164
Gait disturbance 44.44 21.99 18 29437 145245 46511362
Haemolysis 44.14 21.99 34 29421 6025 46650582
Clostridium difficile infection 44.08 21.99 66 29389 25037 46631570
Myocardial infarction 44.04 21.99 5 29450 97523 46559084
Enterococcal infection 44.03 21.99 36 29419 6951 46649656
Neutropenic sepsis 43.57 21.99 46 29409 12278 46644329
Blood pressure increased 43.38 21.99 13 29442 126653 46529954
Swelling 42.24 21.99 13 29442 124498 46532109
Insomnia 42.10 21.99 26 29429 164898 46491709
Muscle twitching 41.94 21.99 49 29406 14623 46641984
Human polyomavirus infection 41.71 21.99 12 29443 207 46656400
Malignant transformation 41.55 21.99 13 29442 302 46656305
Blood magnesium decreased 40.60 21.99 42 29413 10950 46645657
Cryptosporidiosis infection 39.23 21.99 12 29443 258 46656349
Arthropathy 39.11 21.99 4 29451 84696 46571911
Human herpesvirus 6 encephalitis 38.91 21.99 10 29445 110 46656497
Palpitations 38.10 21.99 7 29448 95252 46561355
Acute lymphocytic leukaemia 38.01 21.99 23 29432 2750 46653857
Cerebral toxoplasmosis 37.79 21.99 15 29440 711 46655896
Mucosal disorder 37.45 21.99 20 29435 1884 46654723
Refractory cytopenia with multilineage dysplasia 37.24 21.99 10 29445 132 46656475
Abdominal pain upper 36.95 21.99 23 29432 145282 46511325
Serum amyloid A protein increased 36.85 21.99 9 29446 79 46656528
Pseudomonal sepsis 36.51 21.99 20 29435 1982 46654625
Drug intolerance 36.41 21.99 24 29431 147025 46509582
Disseminated toxoplasmosis 36.17 21.99 9 29446 86 46656521
Vomiting 35.58 21.99 156 29299 452638 46203969
Hepatic failure 35.13 21.99 70 29385 33346 46623261
Scedosporium infection 35.02 21.99 13 29442 513 46656094
Chronic graft versus host disease in liver 34.95 21.99 10 29445 169 46656438
Respiratory syncytial virus infection 34.94 21.99 27 29428 4808 46651799
Metastatic malignant melanoma 34.82 21.99 17 29438 1327 46655280
Asthenia 34.74 21.99 92 29363 310983 46345624
Bone marrow transplant rejection 34.74 21.99 8 29447 53 46656554
Stenotrophomonas infection 34.66 21.99 18 29437 1602 46655005
Cough 34.15 21.99 58 29397 230191 46426416
Contraindicated product administered 33.92 21.99 5 29450 79942 46576665
Graft versus host disease in eye 33.87 21.99 8 29447 60 46656547
Contusion 33.78 21.99 7 29448 87480 46569127
Pseudomonas infection 33.75 21.99 36 29419 9722 46646885
Pericardial effusion 33.71 21.99 59 29396 25484 46631123
Systemic candida 33.27 21.99 21 29434 2706 46653901
Recurrent cancer 33.27 21.99 18 29437 1741 46654866
Musculoskeletal pain 33.20 21.99 3 29452 70125 46586482
Gastrooesophageal reflux disease 33.09 21.99 4 29451 74340 46582267
Weight increased 33.05 21.99 33 29422 164440 46492167
Aphasia 32.66 21.99 62 29393 28505 46628102
Geotrichum infection 32.66 21.99 12 29443 460 46656147
Retinal haemorrhage 32.55 21.99 26 29429 4857 46651750
Staphylococcal bacteraemia 32.45 21.99 26 29429 4878 46651729
Febrile bone marrow aplasia 32.41 21.99 30 29425 6832 46649775
Dedifferentiated liposarcoma 32.40 21.99 7 29448 33 46656574
Chronic graft versus host disease in intestine 32.38 21.99 8 29447 74 46656533
Urticaria 32.34 21.99 17 29438 117875 46538732
Microsporidia infection 31.93 21.99 10 29445 233 46656374
Bacterial infection 31.91 21.99 45 29410 16171 46640436
Cerebrovascular accident 31.75 21.99 12 29443 101027 46555580
Aplastic anaemia 31.35 21.99 30 29425 7123 46649484
Toxic leukoencephalopathy 30.81 21.99 12 29443 541 46656066
Escherichia bacteraemia 30.56 21.99 20 29435 2741 46653866
Skin toxicity 29.94 21.99 22 29433 3632 46652975
Infection reactivation 29.79 21.99 13 29442 784 46655823
Hepatitis B 29.73 21.99 22 29433 3671 46652936
Delayed engraftment 29.70 21.99 7 29448 52 46656555
Erythema 29.45 21.99 28 29427 142792 46513815
Myocarditis 29.36 21.99 30 29425 7709 46648898
Klebsiella infection 29.31 21.99 28 29427 6634 46649973
Capillary leak syndrome 29.31 21.99 17 29438 1880 46654727
Gene mutation 29.00 21.99 14 29441 1066 46655541
Candida sepsis 29.00 21.99 15 29440 1324 46655283
Immune reconstitution inflammatory syndrome 28.94 21.99 26 29429 5699 46650908
Mycobacterium kansasii infection 28.91 21.99 8 29447 119 46656488
Dysplasia 28.80 21.99 12 29443 645 46655962
Haematotoxicity 28.37 21.99 28 29427 6905 46649702
Disseminated tuberculosis 28.20 21.99 19 29436 2733 46653874
B-cell small lymphocytic lymphoma 28.00 21.99 6 29449 27 46656580
Adrenal haemorrhage 28.00 21.99 10 29445 353 46656254
Myalgia 27.96 21.99 22 29433 123066 46533541
Blood glucose increased 27.31 21.99 6 29449 72007 46584600
Metastases to diaphragm 27.16 21.99 6 29449 32 46656575
Enterobacter bacteraemia 26.88 21.99 9 29446 261 46656346
Liver disorder 26.73 21.99 67 29388 37179 46619428
Gastritis fungal 26.68 21.99 7 29448 84 46656523
Rash 26.67 21.99 125 29330 356387 46300220
Bronchitis 26.63 21.99 17 29438 105962 46550645
Systemic inflammatory response syndrome 26.38 21.99 24 29431 5347 46651260
Pleural effusion 26.38 21.99 113 29342 82839 46573768
Peritoneal mesothelioma malignant 26.36 21.99 5 29450 10 46656597
Cardiac failure 26.27 21.99 110 29345 79838 46576769
Syncope 26.07 21.99 17 29438 104786 46551821
Immune thrombocytopenia 26.05 21.99 29 29426 8212 46648395
Clostridium difficile colitis 25.99 21.99 44 29411 18509 46638098
Neoplasm progression 25.80 21.99 54 29401 26629 46629978
Venous haemorrhage 25.73 21.99 8 29447 182 46656425
Haemoglobin decreased 25.72 21.99 154 29301 128795 46527812
Dehydration 25.71 21.99 38 29417 159502 46497105
Blindness cortical 25.63 21.99 10 29445 453 46656154
Chest pain 25.59 21.99 45 29410 176279 46480328
Fungal sepsis 25.28 21.99 13 29442 1134 46655473
Diarrhoea 25.19 21.99 229 29226 559373 46097234
Hyperbilirubinaemia 25.18 21.99 32 29423 10406 46646201
Myeloid leukaemia 25.08 21.99 9 29446 322 46656285
B-lymphocyte count abnormal 25.06 21.99 6 29449 48 46656559
Guillain-Barre syndrome 24.99 21.99 19 29436 3303 46653304
Escherichia sepsis 24.96 21.99 21 29434 4217 46652390
Encephalitis cytomegalovirus 24.46 21.99 10 29445 512 46656095
Dry mouth 24.33 21.99 3 29452 54923 46601684
Hyperhidrosis 24.31 21.99 13 29442 89295 46567312
Idiopathic pneumonia syndrome 24.06 21.99 9 29446 363 46656244
Therapeutic product effect decreased 24.03 21.99 11 29444 82590 46574017
Hypoglycaemia 24.00 21.99 3 29452 54346 46602261
Bronchiolitis 23.95 21.99 16 29439 2269 46654338
Cytomegalovirus enterocolitis 23.82 21.99 10 29445 548 46656059
Hilar lymphadenopathy 23.69 21.99 12 29443 1014 46655593
Chronic obstructive pulmonary disease 23.55 21.99 4 29451 57629 46598978
Metastases to bone marrow 23.51 21.99 8 29447 244 46656363
Dyspepsia 23.48 21.99 7 29448 68465 46588142
Haemolytic anaemia 23.47 21.99 30 29425 9812 46646795
Septic embolus 23.39 21.99 11 29444 790 46655817
Out of specification test results 23.35 21.99 6 29449 66 46656541
Lung consolidation 22.88 21.99 19 29436 3748 46652859
Gastroenteritis adenovirus 22.86 21.99 7 29448 151 46656456
B-cell lymphoma recurrent 22.75 21.99 9 29446 423 46656184
Primary mediastinal large B-cell lymphoma 22.74 21.99 5 29450 26 46656581
Hepatic vein occlusion 22.72 21.99 6 29449 74 46656533
Refractory anaemia with an excess of blasts 22.69 21.99 9 29446 426 46656181
Gastrointestinal toxicity 22.55 21.99 20 29435 4311 46652296
Neutropenic infection 22.52 21.99 12 29443 1126 46655481
Left ventricular dysfunction 22.50 21.99 30 29425 10225 46646382

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Acute graft versus host disease 1459.97 16.95 477 42496 5387 29904118
Cytokine release syndrome 1374.91 16.95 522 42451 9411 29900094
Acute graft versus host disease in skin 1106.33 16.95 363 42610 4153 29905352
Cytomegalovirus infection 1049.47 16.95 561 42412 23113 29886392
Graft versus host disease 801.08 16.95 357 42616 9793 29899712
Chronic graft versus host disease 681.59 16.95 247 42726 3872 29905633
Febrile neutropenia 621.70 16.95 764 42209 105929 29803576
Hypogammaglobulinaemia 560.95 16.95 229 42744 5023 29904482
Adenovirus infection 546.05 16.95 212 42761 4056 29905449
Graft versus host disease in gastrointestinal tract 537.65 16.95 192 42781 2877 29906628
Epstein-Barr virus infection 494.39 16.95 225 42748 6481 29903024
Acute graft versus host disease in intestine 449.93 16.95 158 42815 2247 29907258
Cystitis haemorrhagic 424.95 16.95 183 42790 4604 29904901
Graft versus host disease in skin 422.07 16.95 164 42809 3143 29906362
Venoocclusive liver disease 419.58 16.95 200 42773 6413 29903092
Progressive multifocal leukoencephalopathy 391.55 16.95 211 42762 8802 29900703
Neurotoxicity 384.20 16.95 238 42735 12944 29896561
Pyrexia 362.16 16.95 1081 41892 293408 29616097
Myelodysplastic syndrome 332.24 16.95 249 42724 18529 29890976
Mucosal inflammation 327.91 16.95 303 42670 30191 29879314
Product use in unapproved indication 320.61 16.95 458 42515 73235 29836270
Cytomegalovirus viraemia 314.59 16.95 157 42816 5572 29903933
BK virus infection 310.85 16.95 143 42830 4221 29905284
Haemophagocytic lymphohistiocytosis 306.31 16.95 185 42788 9606 29899899
Human herpesvirus 6 infection 303.74 16.95 112 42861 1846 29907659
Thrombotic microangiopathy 298.92 16.95 174 42799 8436 29901069
Cytopenia 295.00 16.95 170 42803 8086 29901419
Acute lymphocytic leukaemia recurrent 260.04 16.95 109 42864 2558 29906947
Acute myeloid leukaemia 254.17 16.95 209 42764 17797 29891708
Venoocclusive disease 246.34 16.95 104 42869 2486 29907019
Posterior reversible encephalopathy syndrome 240.54 16.95 152 42821 8555 29900950
Lymphocyte count decreased 235.72 16.95 205 42768 18850 29890655
Acute myeloid leukaemia recurrent 234.20 16.95 87 42886 1465 29908040
Neutropenia 227.14 16.95 541 42432 127999 29781506
Post transplant lymphoproliferative disorder 227.00 16.95 123 42850 5183 29904322
Diffuse large B-cell lymphoma 221.91 16.95 139 42834 7702 29901803
Acute graft versus host disease in liver 217.88 16.95 78 42895 1176 29908329
Multiple organ dysfunction syndrome 211.67 16.95 349 42624 63138 29846367
Bone marrow failure 207.04 16.95 234 42739 29551 29879954
Transplant failure 206.79 16.95 91 42882 2413 29907092
Bronchopulmonary aspergillosis 202.02 16.95 156 42817 12128 29897377
Autoimmune haemolytic anaemia 190.25 16.95 100 42873 3959 29905546
Fatigue 184.26 16.95 117 42856 320556 29588949
Chronic lymphocytic leukaemia 180.67 16.95 101 42872 4527 29904978
Leukaemia recurrent 169.81 16.95 69 42904 1492 29908013
Fall 168.85 16.95 29 42944 181843 29727662
Chronic graft versus host disease in skin 168.67 16.95 56 42917 664 29908841
Viral haemorrhagic cystitis 166.52 16.95 58 42915 803 29908702
Immune effector cell-associated neurotoxicity syndrome 159.18 16.95 56 42917 800 29908705
Dizziness 156.78 16.95 43 42930 194866 29714639
Chronic lymphocytic leukaemia recurrent 143.60 16.95 44 42929 394 29909111
Pancytopenia 141.43 16.95 350 42623 84702 29824803
Cytomegalovirus infection reactivation 140.56 16.95 62 42911 1653 29907852
Haematocrit decreased 139.43 16.95 195 42778 30504 29879001
Engraftment syndrome 137.91 16.95 50 42923 783 29908722
JC virus infection 134.84 16.95 61 42912 1729 29907776
Epstein-Barr virus associated lymphoproliferative disorder 130.52 16.95 59 42914 1669 29907836
Completed suicide 128.38 16.95 3 42970 99489 29810016
Pain 121.39 16.95 48 42925 172593 29736912
Aspergillus infection 120.48 16.95 107 42866 10107 29899398
Cystitis viral 120.18 16.95 39 42934 428 29909077
Neutrophil count decreased 119.90 16.95 217 42756 42237 29867268
Dyspnoea 119.47 16.95 184 42789 333111 29576394
Epstein-Barr viraemia 118.89 16.95 46 42927 870 29908635
Drug interaction 118.27 16.95 70 42903 199498 29710007
Asthenia 115.91 16.95 89 42884 221201 29688304
B-cell type acute leukaemia 115.80 16.95 34 42939 259 29909246
Myocardial infarction 114.39 16.95 21 42952 125604 29783901
Bacteraemia 105.94 16.95 121 42852 15439 29894066
Graft versus host disease in liver 104.58 16.95 43 42930 959 29908546
Fungal infection 103.33 16.95 112 42861 13488 29896017
Cytomegalovirus test positive 101.56 16.95 64 42909 3581 29905924
Pneumonia cytomegaloviral 100.98 16.95 58 42915 2738 29906767
Arthralgia 100.03 16.95 35 42938 135756 29773749
Herpes simplex 99.10 16.95 68 42905 4396 29905109
Engraft failure 97.27 16.95 33 42940 420 29909085
Overdose 97.13 16.95 6 42967 84331 29825174
Off label use 96.97 16.95 650 42323 248640 29660865
Fusarium infection 95.46 16.95 41 42932 1023 29908482
Encephalitis viral 93.91 16.95 42 42931 1158 29908347
Bone marrow transplant rejection 92.38 16.95 26 42947 167 29909338
Mucormycosis 91.20 16.95 69 42904 5199 29904306
Rhinovirus infection 88.70 16.95 54 42919 2841 29906664
Constipation 88.64 16.95 26 42947 112880 29796625
Stem cell transplant 87.26 16.95 48 42925 2083 29907422
Microsporidia infection 84.36 16.95 32 42941 572 29908933
Anxiety 81.82 16.95 15 42958 89856 29819649
Malaise 81.32 16.95 72 42901 166890 29742615
Lymphopenia 80.68 16.95 97 42876 13066 29896439
Depression 80.41 16.95 16 42957 90421 29819084
Lymphadenopathy 79.74 16.95 133 42840 24243 29885262
Pruritus 79.57 16.95 35 42938 118169 29791336
Second primary malignancy 77.78 16.95 68 42905 6288 29903217
Encephalitis 77.05 16.95 68 42905 6368 29903137
Pain in extremity 76.81 16.95 31 42942 110190 29799315
Respiratory failure 75.45 16.95 315 42658 100327 29809178
Systemic mycosis 74.73 16.95 36 42937 1180 29908325
Nausea 73.89 16.95 202 42771 296755 29612750
Toxoplasmosis 73.70 16.95 34 42939 1009 29908496
Weight decreased 73.58 16.95 65 42908 150856 29758649
Dehydration 73.55 16.95 43 42930 123496 29786009
Pneumonia fungal 71.36 16.95 61 42912 5472 29904033
Insomnia 70.54 16.95 23 42950 93313 29816192
White blood cell count decreased 70.29 16.95 272 42701 83675 29825830
Idiopathic pneumonia syndrome 69.99 16.95 22 42951 216 29909289
Chest pain 69.94 16.95 41 42932 117586 29791919
Encephalitis cytomegalovirus 69.39 16.95 25 42948 384 29909121
Blood pressure increased 67.67 16.95 11 42962 71917 29837588
Encephalopathy 67.15 16.95 145 42828 32060 29877445
Death 65.76 16.95 277 42696 357006 29552499
Cerebral toxoplasmosis 65.40 16.95 35 42938 1437 29908068
Cerebral aspergillosis 65.18 16.95 34 42939 1324 29908181
Gait disturbance 64.88 16.95 14 42959 74763 29834742
Platelet count decreased 64.39 16.95 312 42661 105817 29803688
Sepsis 63.66 16.95 393 42580 146002 29763503
Thrombocytopenia 62.82 16.95 373 42600 136671 29772834
Chronic graft versus host disease in liver 62.64 16.95 21 42952 257 29909248
Nasopharyngitis 62.64 16.95 6 42967 58843 29850662
Minimal residual disease 61.59 16.95 20 42953 220 29909285
Bacterial infection 61.58 16.95 83 42890 12527 29896978
Chronic lymphocytic leukaemia transformation 60.31 16.95 19 42954 188 29909317
Respiratory syncytial virus infection 60.26 16.95 45 42928 3323 29906182
Feeling abnormal 59.85 16.95 6 42967 56750 29852755
Cytomegalovirus chorioretinitis 59.23 16.95 44 42929 3224 29906281
Diffuse large B-cell lymphoma recurrent 58.95 16.95 37 42936 2055 29907450
Syncope 57.33 16.95 25 42948 84878 29824627
Parainfluenzae virus infection 57.32 16.95 36 42937 2002 29907503
Adenoviral haemorrhagic cystitis 56.76 16.95 22 42951 418 29909087
Staphylococcal sepsis 56.63 16.95 69 42904 9422 29900083
Human herpesvirus 6 encephalitis 56.42 16.95 17 42956 143 29909362
Disseminated intravascular coagulation 55.89 16.95 108 42865 22063 29887442
Hypoxia 55.67 16.95 173 42800 47681 29861824
Leukoencephalopathy 55.48 16.95 46 42927 3956 29905549
Toxic leukoencephalopathy 54.47 16.95 18 42955 210 29909295
Hepatic failure 54.27 16.95 138 42835 33905 29875600
Toxicity to various agents 54.01 16.95 108 42865 177075 29732430
Chronic graft versus host disease in intestine 53.57 16.95 18 42955 222 29909283
Back pain 52.65 16.95 42 42931 102554 29806951
Hypoglycaemia 52.19 16.95 6 42967 50975 29858530
Obliterative bronchiolitis 51.86 16.95 28 42945 1170 29908335
Peripheral swelling 51.83 16.95 12 42961 61062 29848443
Drug hypersensitivity 51.55 16.95 17 42956 68502 29841003
Infection 51.32 16.95 235 42738 77839 29831666
Bacterial sepsis 51.04 16.95 48 42925 4878 29904627
Meningoencephalitis herpetic 50.76 16.95 24 42949 754 29908751
Capillary leak syndrome 50.74 16.95 31 42942 1641 29907864
Acute respiratory distress syndrome 50.44 16.95 107 42866 23365 29886140
Varicella zoster virus infection 50.37 16.95 28 42945 1240 29908265
Pre-engraftment immune reaction 50.28 16.95 14 42959 86 29909419
Rhabdomyolysis 49.21 16.95 15 42958 63565 29845940
Chronic lymphocytic leukaemia refractory 48.96 16.95 14 42959 96 29909409
Muscle spasms 48.93 16.95 16 42957 64822 29844683
Blood glucose increased 48.56 16.95 14 42959 61516 29847989
Chronic obstructive pulmonary disease 48.31 16.95 5 42968 46121 29863384
Acute lymphocytic leukaemia 48.28 16.95 38 42935 3034 29906471
Autoimmune lymphoproliferative syndrome 47.30 16.95 15 42958 152 29909353
Haemolysis 47.14 16.95 55 42918 7176 29902329
Cerebrovascular accident 46.96 16.95 31 42942 83446 29826059
Septic shock 45.98 16.95 197 42776 63410 29846095
B-cell aplasia 45.85 16.95 12 42961 56 29909449
Candida sepsis 45.67 16.95 25 42948 1074 29908431
Diarrhoea 45.56 16.95 287 42686 333816 29575689
Pneumocystis jirovecii pneumonia 45.13 16.95 85 42888 17035 29892470
Klebsiella sepsis 44.98 16.95 29 42944 1688 29907817
Stenotrophomonas infection 43.96 16.95 28 42945 1596 29907909
Out of specification test results 43.88 16.95 10 42963 22 29909483
Blood stem cell transplant failure 43.55 16.95 18 42955 407 29909098
Polyomavirus viraemia 43.54 16.95 19 42954 493 29909012
Aphasia 43.38 16.95 90 42883 19349 29890156
Graft versus host disease in eye 43.24 16.95 15 42958 205 29909300
Enterococcal infection 43.03 16.95 56 42917 8168 29901337
Enterococcal sepsis 42.35 16.95 27 42946 1541 29907964
Joint swelling 42.35 16.95 8 42965 46938 29862567
Viral sinusitis 42.26 16.95 11 42962 50 29909455
Decreased appetite 41.80 16.95 96 42877 149814 29759691
Pulmonary haemorrhage 41.63 16.95 59 42914 9333 29900172
Lymphoproliferative disorder 41.39 16.95 31 42942 2299 29907206
Foetal exposure during pregnancy 41.32 16.95 3 42970 36868 29872637
Malignant neoplasm progression 41.29 16.95 209 42764 72078 29837427
Leukaemic infiltration 40.61 16.95 11 42962 60 29909445
Vomiting 40.57 16.95 170 42803 219648 29689857
Immune thrombocytopenia 40.20 16.95 52 42921 7539 29901966
Candida infection 40.15 16.95 76 42897 15286 29894219
Serum ferritin increased 39.94 16.95 44 42929 5393 29904112
Blood fibrinogen decreased 39.73 16.95 22 42951 967 29908538
Neutropenic sepsis 39.66 16.95 64 42909 11345 29898160
5q minus syndrome 39.47 16.95 13 42960 150 29909355
Autoimmune neutropenia 39.14 16.95 15 42958 276 29909229
B-lymphocyte count abnormal 38.85 16.95 8 42965 8 29909497
Blood creatine phosphokinase increased 38.45 16.95 8 42965 43840 29865665
Meningitis cryptococcal 38.36 16.95 28 42945 1996 29907509
Glomerulosclerosis 38.34 16.95 19 42954 663 29908842
Acute myocardial infarction 38.32 16.95 14 42959 52925 29856580
Coronary artery disease 37.98 16.95 12 42961 49700 29859805
Hepatic vein occlusion 37.71 16.95 12 42961 123 29909382
Asthma 37.67 16.95 4 42969 36170 29873335
Loss of consciousness 37.66 16.95 35 42938 79340 29830165
Neurological decompensation 37.03 16.95 29 42944 2299 29907206
Meningomyelitis herpes 37.01 16.95 9 42964 29 29909476
Splenomegaly 36.87 16.95 68 42905 13412 29896093
Pulmonary embolism 36.43 16.95 35 42938 78100 29831405
Pneumatosis intestinalis 35.39 16.95 30 42943 2660 29906845
Transplant rejection 35.27 16.95 54 42919 9152 29900353
Tumour lysis syndrome 35.24 16.95 65 42908 12820 29896685
Hyperkalaemia 35.15 16.95 26 42947 65984 29843521
Suicidal ideation 35.15 16.95 5 42968 36109 29873396
Nephropathy toxic 34.71 16.95 58 42915 10581 29898924
Systemic candida 34.68 16.95 30 42943 2734 29906771
Weight increased 34.41 16.95 34 42939 74879 29834626
Pseudomonas infection 34.01 16.95 57 42916 10425 29899080
Hyperhidrosis 33.74 16.95 28 42945 67062 29842443
Abdominal discomfort 33.51 16.95 14 42959 48777 29860728
Bradycardia 33.38 16.95 27 42946 65499 29844006
Musculoskeletal pain 33.33 16.95 3 42970 30937 29878568
Intentional product misuse 33.27 16.95 5 42968 34662 29874843
Haemolytic anaemia 33.23 16.95 55 42918 9955 29899550
Haemoglobin decreased 33.08 16.95 278 42695 113820 29795685
Mucosal toxicity 32.97 16.95 12 42961 190 29909315
Respiratory tract infection fungal 32.97 16.95 17 42956 646 29908859
Chloroma 32.96 16.95 15 42958 431 29909074
Mucosal disorder 32.74 16.95 23 42950 1544 29907961
Musculoskeletal stiffness 32.61 16.95 6 42967 35875 29873630
Post transplant distal limb syndrome 32.60 16.95 13 42960 267 29909238
Myelitis 32.56 16.95 17 42956 663 29908842
Non-Hodgkin's lymphoma recurrent 32.39 16.95 8 42965 28 29909477
Aplasia pure red cell 32.10 16.95 40 42933 5586 29903919
Aggression 31.81 16.95 7 42966 36900 29872605
Acute erythroid leukaemia 31.66 16.95 11 42962 151 29909354
Refractory anaemia with an excess of blasts 31.43 16.95 14 42959 382 29909123
Stomatitis 31.32 16.95 121 42852 37158 29872347
Therapeutic product effect decreased 30.84 16.95 3 42970 29073 29880432
Coronavirus infection 30.47 16.95 31 42942 3467 29906038
Organising pneumonia 30.45 16.95 37 42936 5037 29904468
Staphylococcal infection 30.38 16.95 104 42869 30120 29879385
Poikiloderma 30.23 16.95 11 42962 174 29909331
Dyspepsia 29.98 16.95 4 42969 30325 29879180
Cardiac disorder 29.82 16.95 10 42963 39883 29869622
Hepatitis B reactivation 29.74 16.95 28 42945 2849 29906656
Rubulavirus test positive 29.66 16.95 6 42967 5 29909500
Chronic kidney disease 29.14 16.95 9 42964 37829 29871676
Headache 28.86 16.95 149 42824 182157 29727348
Autoimmune pancytopenia 28.66 16.95 9 42964 88 29909417
Achromobacter infection 28.61 16.95 8 42965 50 29909455
Lymphocytosis 28.05 16.95 23 42950 1947 29907558
Stenotrophomonas sepsis 28.05 16.95 9 42964 95 29909410
Condition aggravated 27.69 16.95 103 42870 137763 29771742
Palpitations 27.69 16.95 7 42966 33566 29875939
Neoplasm progression 27.62 16.95 72 42901 17951 29891554
Unevaluable event 27.45 16.95 6 42967 31779 29877726
CNS ventriculitis 27.41 16.95 11 42962 230 29909275
Epstein-Barr virus test positive 27.32 16.95 14 42959 525 29908980
Disseminated toxoplasmosis 27.23 16.95 7 42966 30 29909475
Pulmonary alveolar haemorrhage 27.20 16.95 40 42933 6541 29902964
Rash 27.02 16.95 163 42810 191726 29717779
Oedema peripheral 26.95 16.95 71 42902 105761 29803744
Kidney fibrosis 26.91 16.95 23 42950 2062 29907443
Eccrine squamous syringometaplasia 26.86 16.95 7 42966 32 29909473
Aplasia 26.80 16.95 31 42942 4006 29905499
Haptoglobin decreased 26.49 16.95 14 42959 560 29908945
Cytokine storm 26.26 16.95 14 42959 570 29908935
Viraemia 26.26 16.95 18 42955 1161 29908344
Clostridium difficile infection 26.21 16.95 65 42908 15718 29893787
Plasmablastic lymphoma 26.20 16.95 11 42962 259 29909246
Gastrooesophageal reflux disease 26.07 16.95 7 42966 32248 29877257
Meningitis viral 26.05 16.95 15 42958 711 29908794
Plasma cell myeloma 26.03 16.95 23 42950 53439 29856066
Urticaria 25.99 16.95 24 42949 54582 29854923
Treatment noncompliance 25.77 16.95 3 42970 25250 29884255
Transient ischaemic attack 25.70 16.95 3 42970 25197 29884308
Pneumonia viral 25.68 16.95 25 42948 2652 29906853
Hypoaesthesia 25.61 16.95 24 42949 54206 29855299
Viral myocarditis 25.36 16.95 9 42964 132 29909373
International normalised ratio increased 25.16 16.95 19 42954 47720 29861785
Pseudomonal sepsis 25.07 16.95 26 42947 2974 29906531
Apoptosis 25.05 16.95 10 42963 206 29909299
Angioedema 25.04 16.95 9 42964 34375 29875130
Chronic myelomonocytic leukaemia 24.74 16.95 14 42959 642 29908863
Complications of bone marrow transplant 24.70 16.95 10 42963 214 29909291
Reticulocytosis 24.63 16.95 11 42962 302 29909203
Cardiac arrest 24.63 16.95 61 42912 92789 29816716
Somnolence 24.57 16.95 65 42908 96698 29812807
Cardiac failure congestive 24.36 16.95 53 42920 84354 29825151
Hyperbilirubinaemia 24.25 16.95 66 42907 16876 29892629
Pneumonia adenoviral 24.09 16.95 9 42964 154 29909351
Roseolovirus test positive 24.08 16.95 8 42965 95 29909410
Hypokalaemia 23.95 16.95 22 42951 50170 29859335
Thrombosis 23.31 16.95 16 42957 42215 29867290
Hypersensitivity 23.14 16.95 26 42947 54002 29855503
Abdominal pain 23.11 16.95 108 42865 135546 29773959
Myalgia 23.08 16.95 47 42926 76620 29832885
Meningeal neoplasm 23.01 16.95 7 42966 61 29909444
Diabetes mellitus 22.92 16.95 16 42957 41849 29867656
Evans syndrome 22.90 16.95 10 42963 260 29909245
Neoplasm recurrence 22.89 16.95 20 42953 1847 29907658
Refractory cytopenia with unilineage dysplasia 22.89 16.95 12 42961 472 29909033
Myeloid leukaemia 22.85 16.95 11 42962 360 29909145
Angina pectoris 22.76 16.95 7 42966 29511 29879994
B-cell lymphoma 22.50 16.95 30 42943 4480 29905025
Rectal haemorrhage 22.46 16.95 11 42962 34928 29874577
Cerebral fungal infection 22.08 16.95 9 42964 196 29909309
Varicella 22.07 16.95 18 42955 1512 29907993
Cardio-respiratory arrest 22.00 16.95 30 42943 57276 29852229
Non-Hodgkin's lymphoma 21.96 16.95 19 42954 1732 29907773
Aplastic anaemia 21.86 16.95 33 42940 5523 29903982
Paraneoplastic pemphigus 21.72 16.95 7 42966 75 29909430
Cytomegalovirus gastroenteritis 21.71 16.95 9 42964 205 29909300
Chest discomfort 21.62 16.95 20 42953 45460 29864045
Upper gastrointestinal haemorrhage 21.55 16.95 3 42970 22025 29887480
Blood bilirubin unconjugated increased 21.54 16.95 13 42960 673 29908832
Precursor T-lymphoblastic lymphoma/leukaemia 21.31 16.95 7 42966 80 29909425
Balance disorder 21.26 16.95 13 42960 36480 29873025
Lung infiltration 21.14 16.95 52 42921 12507 29896998
Premature ageing 21.00 16.95 7 42966 84 29909421
Polymyositis 20.94 16.95 17 42956 1419 29908086
Gallbladder adenocarcinoma 20.83 16.95 5 42968 15 29909490
Refractory cytopenia with multilineage dysplasia 20.74 16.95 8 42965 150 29909355
Swelling 20.71 16.95 13 42960 35962 29873543
Pleural effusion 20.67 16.95 179 42794 73887 29835618
Urinary tract infection 20.64 16.95 47 42926 73612 29835893
Hepatosplenomegaly 20.62 16.95 26 42947 3675 29905830
Escherichia sepsis 20.59 16.95 27 42946 3967 29905538
Hyponatraemia 20.39 16.95 41 42932 67161 29842344
Mobility decreased 20.35 16.95 6 42967 25993 29883512
Arthritis 20.29 16.95 5 42968 24396 29885109
Medication error 20.18 16.95 3 42970 20969 29888536
Diffuse alveolar damage 20.15 16.95 19 42954 1937 29907568
Skin toxicity 20.00 16.95 24 42949 3225 29906280
Adenomatous polyposis coli 19.86 16.95 8 42965 169 29909336
Spirochaetal infection 19.53 16.95 5 42968 21 29909484
Graft versus host disease in lung 19.51 16.95 11 42962 501 29909004
Flushing 19.40 16.95 9 42964 29483 29880022
Citrobacter infection 19.37 16.95 11 42962 508 29908997
Paraesthesia 19.33 16.95 30 42943 54297 29855208
Retinal infiltrates 19.16 16.95 5 42968 23 29909482
Infection in an immunocompromised host 19.16 16.95 12 42961 664 29908841
Injury 18.97 16.95 4 42969 21727 29887778
Gastroenteritis norovirus 18.90 16.95 16 42957 1416 29908089
Coombs direct test positive 18.88 16.95 9 42964 288 29909217
Corynebacterium infection 18.83 16.95 10 42963 404 29909101
Cytomegalovirus colitis 18.78 16.95 20 42953 2359 29907146
Drug withdrawal syndrome 18.68 16.95 3 42970 19806 29889699
Gastroenteritis sapovirus 18.56 16.95 7 42966 123 29909382
Clostridium difficile colitis 18.54 16.95 50 42923 12718 29896787
Pneumonia pseudomonal 18.47 16.95 24 42949 3494 29906011
Fungal sepsis 18.45 16.95 12 42961 709 29908796
Heart rate increased 18.44 16.95 17 42956 38704 29870801
Contusion 18.42 16.95 11 42962 31269 29878236
Abnormal behaviour 18.16 16.95 7 42966 25616 29883889
Rhinocerebral mucormycosis 18.16 16.95 6 42967 70 29909435
Disease recurrence 18.15 16.95 53 42920 14108 29895397
Influenza like illness 18.14 16.95 7 42966 25598 29883907
JC polyomavirus test positive 18.13 16.95 11 42962 575 29908930
Drug intolerance 18.11 16.95 23 42950 45268 29864237
Bacillus infection 18.07 16.95 8 42965 215 29909290
Lower respiratory tract infection fungal 18.04 16.95 11 42962 580 29908925
Human herpes virus 6 serology positive 17.77 16.95 7 42966 139 29909366
Mycobacterium kansasii infection 17.70 16.95 8 42965 226 29909279
Herpes virus infection 17.67 16.95 20 42953 2524 29906981
Infection reactivation 17.66 16.95 13 42960 939 29908566
Cryptosporidiosis infection 17.63 16.95 9 42964 335 29909170
Peptic ulcer haemorrhage 17.54 16.95 10 42963 465 29909040
Pneumonia respiratory syncytial viral 17.54 16.95 11 42962 610 29908895
Arthritis fungal 17.50 16.95 6 42967 79 29909426
Gait inability 17.44 16.95 3 42970 18838 29890667
Paraparesis 17.38 16.95 17 42956 1814 29907691
Growth retardation 17.36 16.95 16 42957 1584 29907921
Neutrophil Pelger-Huet anomaly present 17.26 16.95 8 42965 240 29909265
Epstein-Barr virus infection reactivation 17.20 16.95 8 42965 242 29909263
Gastrointestinal infection 17.20 16.95 24 42949 3741 29905764
Hepatitis viral 17.20 16.95 10 42963 483 29909022
Basophilia 17.20 16.95 4 42969 10 29909495
Osteonecrosis of jaw 17.16 16.95 3 42970 18615 29890890
Staphylococcal bacteraemia 17.09 16.95 33 42940 6735 29902770
Lactic acidosis 16.99 16.95 12 42961 31201 29878304

Pharmacologic Action:

SourceCodeDescription
ATC L01BB05 ANTINEOPLASTIC AND IMMUNOMODULATING AGENTS
ANTINEOPLASTIC AGENTS
ANTIMETABOLITES
Purine analogues
MeSH PA D000963 Antimetabolites
MeSH PA D000964 Antimetabolites, Antineoplastic
MeSH PA D000970 Antineoplastic Agents
MeSH PA D007155 Immunologic Factors
MeSH PA D007166 Immunosuppressive Agents
MeSH PA D009676 Noxae
FDA MoA N0000000233 Nucleic Acid Synthesis Inhibitors
FDA EPC N0000175595 Nucleoside Metabolic Inhibitor
CHEBI has role CHEBI:22587 antiviral agents
CHEBI has role CHEBI:35221 antimetabolite
CHEBI has role CHEBI:35610 cytostatic
CHEBI has role CHEBI:35705 immunosuppressant
CHEBI has role CHEBI:50266 prodrugs
CHEBI has role CHEBI:59517 dna synthesis inhibitors

Drug Use (View source of the data)

DiseaseRelationSNOMED_IDDOID
Chronic lymphoid leukemia, disease indication 92814006
Acute myeloid leukemia, disease off-label use 91861009
Waldenström macroglobulinemia off-label use 190818004 DOID:0050747
Follicular non-Hodgkin's lymphoma off-label use 308121000
Mycosis contraindication 3218000 DOID:1564
Herpes zoster contraindication 4740000 DOID:8536
Acquired hemolytic anemia contraindication 4854004
Acquired factor VIII deficiency disease contraindication 14230004
Progressive multifocal leukoencephalopathy contraindication 22255007 DOID:643
Feeling agitated contraindication 24199005
Idiopathic thrombocytopenic purpura contraindication 32273002 DOID:8924
Extrinsic allergic alveolitis contraindication 37471005 DOID:841
Conduction disorder of the heart contraindication 44808001
Acute nephropathy contraindication 58574008
Acute infectious disease contraindication 63171007
Interstitial pneumonia contraindication 64667001
Optic neuritis contraindication 66760008 DOID:1210
Evans syndrome contraindication 75331009 DOID:8931
Disorder of optic nerve contraindication 77157004 DOID:1891
Bacterial infectious disease contraindication 87628006
Pancytopenia contraindication 127034005 DOID:12450
Autoimmune thrombocytopenia contraindication 128091003
Seizure disorder contraindication 128613002
Liver function tests abnormal contraindication 166603001
Decompensated cardiac failure contraindication 195111005
Impaired renal function disorder contraindication 197663003
Edema contraindication 267038008
Anemia contraindication 271737000 DOID:2355
Uric acid renal calculus contraindication 274401005
Pregnancy, function contraindication 289908002
Neutropenic disorder contraindication 303011007 DOID:1227
Bone marrow depression contraindication 307762000
Coma contraindication 371632003
Impaired cognition contraindication 386806002
Visual impairment contraindication 397540003
Autoimmune hemolytic anemia contraindication 413603009 DOID:718
Breastfeeding (mother) contraindication 413712001
Chemotherapy-Induced Hyperuricemia contraindication
CNS Toxicity contraindication

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 1.31 acidic
pKa2 6.36 acidic
pKa3 12.46 acidic
pKa4 13.04 acidic
pKa5 2.93 Basic
pKa6 2.33 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
DNA polymerase alpha catalytic subunit Enzyme INHIBITOR WOMBAT-PK DRUG LABEL
Ribonucleoside-diphosphate reductase subunit M2 Enzyme INHIBITOR IC50 6 IUPHAR
Ribonucleoside-diphosphate reductase large subunit Enzyme INHIBITOR IC50 6 IUPHAR
Adenosine receptor A1 GPCR Ki 8.23 CHEMBL
Adenosine receptor A3 GPCR Ki 4.98 CHEMBL
Adenosine receptor A2a GPCR Ki 7.55 CHEMBL

External reference:

IDSource
4020528 VUID
N0000148244 NUI
D01907 KEGG_DRUG
21679-14-1 SECONDARY_CAS_RN
4020177 VANDF
4020528 VANDF
C0060483 UMLSCUI
C0059985 UMLSCUI
CHEBI:63599 CHEBI
3368 PUBCHEM_CID
CHEMBL1096882 ChEMBL_ID
CHEMBL1568 ChEMBL_ID
C042382 MESH_SUPPLEMENTAL_RECORD_UI
C024352 MESH_SUPPLEMENTAL_RECORD_UI
5214 INN_ID
1X9VK9O1SC UNII
P2K93U8740 UNII
657237 PUBCHEM_CID
4802 IUPHAR_LIGAND_ID
DB01073 DRUGBANK_ID
24698 RXNORM
110964 MMSL
1862 MMSL
4734 MMSL
d01346 MMSL
003618 NDDF
004817 NDDF
108763009 SNOMEDCT_US
108765002 SNOMEDCT_US
386907005 SNOMEDCT_US

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
fludarabine phosphate HUMAN PRESCRIPTION DRUG LABEL 1 24201-237 INJECTION, POWDER, LYOPHILIZED, FOR SOLUTION 25 mg INTRAVENOUS ANDA 24 sections
Fludarabine Phosphate HUMAN PRESCRIPTION DRUG LABEL 1 25021-242 INJECTION, SOLUTION 25 mg INTRAVENOUS ANDA 28 sections
Fludarabine phosphate HUMAN PRESCRIPTION DRUG LABEL 1 45963-609 INJECTION, POWDER, LYOPHILIZED, FOR SOLUTION 50 mg INTRAVENOUS ANDA 21 sections
Fludarabine phosphate HUMAN PRESCRIPTION DRUG LABEL 1 45963-621 INJECTION, SOLUTION 25 mg INTRAVENOUS ANDA 19 sections
Fludarabine Phosphate HUMAN PRESCRIPTION DRUG LABEL 1 59923-604 INJECTION 25 mg INTRAVENOUS ANDA 28 sections
Fludarabine Phosphate HUMAN PRESCRIPTION DRUG LABEL 1 61703-344 INJECTION, POWDER, LYOPHILIZED, FOR SOLUTION 50 mg INTRAVENOUS ANDA 14 sections
Fludarabine HUMAN PRESCRIPTION DRUG LABEL 1 63323-192 INJECTION, SOLUTION 25 mg INTRAVENOUS ANDA 14 sections