fludarabine phosphate 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
arabinofuranosyl derivatives 1189 75607-67-9

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • fludarabine 5'-monophosphate
  • fludarabine phosphate
  • fludura
  • fludara
  • 2-F-ara-AMP
  • Molecular weight: 365.21
  • Formula: C10H13FN5O7P
  • CLOGP: -3.13
  • LIPINSKI: 1
  • HAC: 12
  • HDO: 5
  • TPSA: 186.07
  • ALOGS: -2.09
  • ROTB: 4
  • Status: OFP
    • Legend:
    OFP - off patent
    OFM - off market
    ONP - on patent

Drug dosage:

None

ADMET properties:

PropertyValueReference
BDDCS (Biopharmaceutical Drug Disposition Classification System) 1 Benet LZ, Broccatelli F, Oprea TI
S (Water solubility) 3.53 mg/mL Benet LZ, Broccatelli F, Oprea TI
MRTD (Maximum Recommended Therapeutic Daily Dose) 2.66 µM/kg/day Contrera JF, Matthews EJ, Kruhlak NL, Benz RD
BA (Bioavailability) 57.50 % Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H

Approvals:

DateAgencyCompanyOrphan
April 18, 1991 FDA
Jan. 26, 2007 PMDA Nihon Schering K.K.

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Cytokine release syndrome 1758.68 22.94 510 30990 10365 56250202
Acute graft versus host disease 1184.68 22.94 305 31195 3870 56256697
Cytomegalovirus infection 986.09 22.94 380 31120 18916 56241651
Febrile neutropenia 794.61 22.94 574 30926 104971 56155596
Graft versus host disease 789.17 22.94 247 31253 6534 56254033
Acute graft versus host disease in skin 679.84 22.94 186 31314 3016 56257551
Chronic graft versus host disease 649.07 22.94 180 31320 3076 56257491
Adenovirus infection 622.78 22.94 176 31324 3232 56257335
Graft versus host disease in skin 601.52 22.94 163 31337 2544 56258023
Cytomegalovirus infection reactivation 548.71 22.94 157 31343 3019 56257548
Graft versus host disease in gastrointestinal tract 501.98 22.94 144 31356 2795 56257772
Neurotoxicity 461.59 22.94 209 31291 15586 56244981
Human herpesvirus 6 infection 460.71 22.94 132 31368 2550 56258017
Hypogammaglobulinaemia 451.25 22.94 160 31340 6266 56254301
Venoocclusive liver disease 427.79 22.94 140 31360 4281 56256286
Cytomegalovirus viraemia 411.53 22.94 141 31359 4979 56255588
Immune effector cell-associated neurotoxicity syndrome 410.15 22.94 108 31392 1500 56259067
Product use in unapproved indication 402.82 22.94 443 31057 140379 56120188
Myelodysplastic syndrome 383.29 22.94 186 31314 16220 56244347
Thrombotic microangiopathy 361.36 22.94 151 31349 9260 56251307
Cystitis haemorrhagic 330.40 22.94 112 31388 3825 56256742
Acute myeloid leukaemia 330.32 22.94 170 31330 16802 56243765
Acute graft versus host disease in intestine 329.15 22.94 92 31408 1618 56258949
Progressive multifocal leukoencephalopathy 329.06 22.94 152 31348 11861 56248706
Acute lymphocytic leukaemia recurrent 323.83 22.94 97 31403 2200 56258367
Neutropenia 321.14 22.94 418 31082 157749 56102818
BK virus infection 320.72 22.94 103 31397 2961 56257606
Pyrexia 307.18 22.94 703 30797 418070 55842497
Epstein-Barr virus infection 304.27 22.94 125 31375 7338 56253229
Haemophagocytic lymphohistiocytosis 296.61 22.94 132 31368 9440 56251127
Post transplant lymphoproliferative disorder 278.17 22.94 103 31397 4569 56255998
Pancytopenia 274.19 22.94 291 31209 88424 56172143
Acute myeloid leukaemia recurrent 270.48 22.94 77 31423 1451 56259116
Bronchopulmonary aspergillosis 269.07 22.94 118 31382 8146 56252421
Multiple organ dysfunction syndrome 260.02 22.94 224 31276 52546 56208021
Premature menopause 258.45 22.94 65 31435 743 56259824
Viral haemorrhagic cystitis 239.68 22.94 61 31439 734 56259833
Pain 230.76 22.94 46 31454 663138 55597429
Encephalitis viral 230.28 22.94 69 31431 1566 56259001
Mucosal inflammation 229.93 22.94 191 31309 42619 56217948
Thrombocytopenia 220.59 22.94 323 31177 135901 56124666
Transplant failure 218.24 22.94 65 31435 1444 56259123
Cytopenia 217.01 22.94 107 31393 9648 56250919
Viraemia 205.23 22.94 58 31442 1063 56259504
Posterior reversible encephalopathy syndrome 193.12 22.94 117 31383 15843 56244724
Venoocclusive disease 192.82 22.94 63 31437 1914 56258653
Aspergillus infection 187.54 22.94 89 31411 7376 56253191
Lymphocyte count decreased 167.59 22.94 133 31367 27806 56232761
Systemic mycosis 155.07 22.94 47 31453 1110 56259457
Epstein-Barr viraemia 154.92 22.94 45 31455 913 56259654
Neutrophil count decreased 147.72 22.94 160 31340 49662 56210905
Chronic graft versus host disease in skin 143.80 22.94 40 31460 690 56259877
Sepsis 143.23 22.94 270 31230 139570 56120997
Bone marrow failure 141.12 22.94 121 31379 28165 56232402
Cytomegalovirus chorioretinitis 137.34 22.94 47 31453 1651 56258916
Joint swelling 136.77 22.94 6 31494 289794 55970773
Leukoencephalopathy 135.18 22.94 59 31441 4023 56256544
Epstein-Barr virus infection reactivation 134.07 22.94 37 31463 619 56259948
Pre-engraftment immune reaction 132.67 22.94 30 31470 208 56260359
Cytomegalovirus test positive 131.26 22.94 52 31448 2774 56257793
Platelet count decreased 130.15 22.94 222 31278 106161 56154406
Adenoviral hepatitis 126.12 22.94 31 31469 320 56260247
Bacterial sepsis 123.54 22.94 54 31446 3695 56256872
Fatigue 123.31 22.94 157 31343 788395 55472172
Alopecia 121.19 22.94 12 31488 293446 55967121
Abdominal discomfort 120.87 22.94 9 31491 277265 55983302
Diffuse large B-cell lymphoma 118.62 22.94 64 31436 6952 56253615
White blood cell count decreased 115.25 22.94 232 31268 125758 56134809
Bacteraemia 114.86 22.94 84 31416 15547 56245020
Fall 113.60 22.94 30 31470 357480 55903087
JC virus infection 113.30 22.94 42 31458 1867 56258700
Stem cell transplant 113.26 22.94 41 31459 1703 56258864
Acute graft versus host disease in liver 110.55 22.94 32 31468 641 56259926
Second primary malignancy 107.26 22.94 61 31439 7341 56253226
Off label use 107.08 22.94 601 30899 555579 55704988
Nasopharyngitis 106.15 22.94 4 31496 220955 56039612
Drug resistance 104.75 22.94 89 31411 20453 56240114
Dizziness 102.87 22.94 41 31459 376099 55884468
Septic shock 102.28 22.94 147 31353 60688 56199879
Drug hypersensitivity 102.07 22.94 16 31484 275189 55985378
Arthralgia 98.44 22.94 82 31418 501587 55758980
Respiratory failure 97.81 22.94 184 31316 94878 56165689
Fusarium infection 95.35 22.94 28 31472 591 56259976
B-cell type acute leukaemia 94.64 22.94 21 31479 132 56260435
Varicella zoster virus infection 94.27 22.94 40 31460 2544 56258023
Fungaemia 91.42 22.94 37 31463 2087 56258480
Engraft failure 91.27 22.94 24 31476 331 56260236
Swelling 91.06 22.94 13 31487 239758 56020809
Peripheral swelling 90.86 22.94 12 31488 234714 56025853
Cystitis viral 90.65 22.94 20 31480 122 56260445
Pain in extremity 90.64 22.94 27 31473 297404 55963163
Hypersensitivity 90.48 22.94 17 31483 256391 56004176
Neoplasm recurrence 89.42 22.94 38 31462 2426 56258141
Pruritus 87.38 22.94 34 31466 316589 55943978
Upper respiratory fungal infection 87.07 22.94 20 31480 150 56260417
Encephalopathy 86.90 22.94 103 31397 35222 56225345
Haematocrit decreased 86.69 22.94 105 31395 36724 56223843
Pneumonia fungal 86.55 22.94 46 31454 4847 56255720
Toxoplasmosis 86.16 22.94 32 31468 1430 56259137
Herpes simplex 85.52 22.94 53 31447 7465 56253102
Headache 85.41 22.94 113 31387 558931 55701636
Hypoxia 84.46 22.94 126 31374 53771 56206796
Contraindicated product administered 84.21 22.94 5 31495 186281 56074286
Rhinovirus infection 84.19 22.94 42 31458 3880 56256687
Systemic lupus erythematosus 84.01 22.94 4 31496 180074 56080493
Growth failure 83.23 22.94 22 31478 310 56260257
Epstein-Barr virus associated lymphoproliferative disorder 83.12 22.94 33 31467 1770 56258797
Encephalitis 81.96 22.94 53 31447 8037 56252530
Staphylococcal infection 81.70 22.94 103 31397 37515 56223052
Adenovirus reactivation 78.96 22.94 18 31482 130 56260437
Arthropathy 78.07 22.94 10 31490 200265 56060302
Leukaemia recurrent 78.02 22.94 29 31471 1299 56259268
Blood follicle stimulating hormone increased 77.78 22.94 18 31482 140 56260427
Diffuse large B-cell lymphoma recurrent 76.98 22.94 31 31469 1726 56258841
Enterococcal infection 75.09 22.94 48 31452 7136 56253431
Anxiety 74.44 22.94 10 31490 193162 56067405
Enterococcal bacteraemia 74.10 22.94 28 31472 1313 56259254
Drug intolerance 73.76 22.94 28 31472 264790 55995777
Engraftment syndrome 72.76 22.94 21 31479 416 56260151
Fungal infection 72.70 22.94 91 31409 32902 56227665
Malignant neoplasm progression 72.66 22.94 140 31360 73447 56187120
Heart rate abnormal 70.38 22.94 39 31461 4464 56256103
Aplastic anaemia 70.20 22.94 50 31450 8878 56251689
Lymphadenitis 70.03 22.94 34 31466 2961 56257606
Mucormycosis 69.44 22.94 33 31467 2741 56257826
Staphylococcal sepsis 69.21 22.94 46 31454 7303 56253264
Aplasia 69.08 22.94 37 31463 3959 56256608
Malaise 68.58 22.94 63 31437 367797 55892770
Chronic lymphocytic leukaemia recurrent 68.51 22.94 17 31483 183 56260384
Lymphopenia 68.29 22.94 64 31436 16710 56243857
Acute respiratory distress syndrome 67.73 22.94 72 31428 21854 56238713
Chronic lymphocytic leukaemia 67.11 22.94 33 31467 2955 56257612
Disseminated mucormycosis 66.87 22.94 16 31484 146 56260421
Minimal residual disease 65.71 22.94 15 31485 109 56260458
Dyspnoea 65.56 22.94 147 31353 592430 55668137
Nausea 65.51 22.94 215 31285 763963 55496604
Wound 65.00 22.94 3 31497 138801 56121766
Meningoencephalitis herpetic 64.46 22.94 24 31476 1080 56259487
Human herpesvirus 6 encephalitis 63.68 22.94 16 31484 182 56260385
Pseudomonas infection 62.64 22.94 49 31451 10022 56250545
Condition aggravated 62.02 22.94 61 31439 344837 55915730
Autoimmune haemolytic anaemia 61.31 22.94 35 31465 4241 56256326
Depression 61.29 22.94 13 31487 180104 56080463
Alternaria infection 60.62 22.94 16 31484 224 56260343
Exposure during pregnancy 60.58 22.94 4 31496 136338 56124229
Lymphadenopathy 60.51 22.94 86 31414 35122 56225445
Therapeutic product effect decreased 60.24 22.94 11 31489 169441 56091126
Pneumonia cytomegaloviral 59.90 22.94 27 31473 1987 56258580
Tumour lysis syndrome 59.15 22.94 43 31457 7880 56252687
Feeling abnormal 59.13 22.94 4 31496 133598 56126969
Graft versus host disease in lung 58.56 22.94 17 31483 344 56260223
Clostridium difficile infection 58.30 22.94 74 31426 27124 56233443
Pulmonary haemorrhage 58.02 22.94 40 31460 6743 56253824
Transplant dysfunction 57.92 22.94 35 31465 4711 56255856
Infection reactivation 57.83 22.94 22 31478 1051 56259516
Systemic candida 57.80 22.94 30 31470 3011 56257556
Klebsiella infection 57.69 22.94 42 31458 7714 56252853
Geotrichum infection 57.20 22.94 18 31482 483 56260084
Pneumocystis jirovecii pneumonia 56.54 22.94 56 31444 15645 56244922
Infusion related reaction 55.05 22.94 24 31476 208907 56051660
Hepatic enzyme increased 53.18 22.94 15 31485 171369 56089198
Rash 53.10 22.94 124 31376 492923 55767644
Nodular melanoma 52.57 22.94 11 31489 50 56260517
Blood pressure increased 52.52 22.94 9 31491 145167 56115400
Graft versus host disease in liver 52.48 22.94 17 31483 502 56260065
Blood stem cell transplant failure 51.97 22.94 13 31487 145 56260422
Constipation 51.95 22.94 24 31476 201919 56058648
Myelosuppression 51.59 22.94 56 31444 17399 56243168
Escherichia bacteraemia 51.44 22.94 29 31471 3431 56257136
Disease progression 51.22 22.94 152 31348 105021 56155546
Weight increased 50.81 22.94 33 31467 229670 56030897
Campylobacter infection 50.16 22.94 19 31481 897 56259670
Clostridium difficile colitis 50.02 22.94 57 31443 18681 56241886
Back pain 49.90 22.94 36 31464 237134 56023433
Pneumonia adenoviral 49.81 22.94 12 31488 113 56260454
Insomnia 49.04 22.94 23 31477 191837 56068730
Polyomavirus viraemia 48.96 22.94 16 31484 486 56260081
Muscle spasms 48.64 22.94 9 31491 137362 56123205
Cerebral toxoplasmosis 48.39 22.94 18 31482 808 56259759
Human polyomavirus infection 48.29 22.94 14 31486 282 56260285
Bone marrow transplant 47.95 22.94 17 31483 664 56259903
Neutropenic sepsis 47.14 22.94 50 31450 15135 56245432
Urticaria 46.13 22.94 12 31488 144664 56115903
Bacterial infection 45.05 22.94 52 31448 17278 56243289
B-cell aplasia 44.78 22.94 10 31490 65 56260502
Abdominal pain upper 44.61 22.94 22 31478 178291 56082276
Contusion 44.23 22.94 9 31491 128421 56132146
Gait disturbance 44.23 22.94 18 31482 163303 56097264
Toxic leukoencephalopathy 43.96 22.94 16 31484 675 56259892
Mobility decreased 43.69 22.94 3 31497 98988 56161579
Vomiting 43.37 22.94 139 31361 498089 55762478
Muscle twitching 42.67 22.94 49 31451 16193 56244374
Aphasia 41.87 22.94 67 31433 30348 56230219
Respiratory syncytial virus infection 41.59 22.94 30 31470 5431 56255136
Pulmonary mucormycosis 41.42 22.94 12 31488 241 56260326
Arthritis 41.37 22.94 4 31496 99848 56160719
Stenotrophomonas infection 40.99 22.94 20 31480 1761 56258806
Acute lymphocytic leukaemia 40.80 22.94 23 31477 2721 56257846
Blood magnesium decreased 40.27 22.94 41 31459 11833 56248734
Bone marrow transplant rejection 40.23 22.94 9 31491 59 56260508
Graft versus host disease in eye 39.85 22.94 9 31491 62 56260505
Haemolysis 39.81 22.94 31 31469 6297 56254270
Disseminated toxoplasmosis 39.70 22.94 10 31490 115 56260452
Pericardial effusion 38.98 22.94 61 31439 27114 56233453
Gene mutation 38.62 22.94 18 31482 1431 56259136
Cryptosporidiosis infection 38.53 22.94 12 31488 311 56260256
Immune reconstitution inflammatory syndrome 38.33 22.94 29 31471 5645 56254922
Urinary tract infection 38.26 22.94 47 31453 240466 56020101
Refractory cytopenia with multilineage dysplasia 38.02 22.94 10 31490 138 56260429
Myocardial infarction 37.75 22.94 4 31496 92866 56167701
Malignant transformation 36.46 22.94 12 31488 373 56260194
Asthenia 36.27 22.94 87 31413 342886 55917681
Retinal haemorrhage 36.25 22.94 26 31474 4665 56255902
Cough 36.14 22.94 56 31444 259905 56000662
Hepatic failure 35.87 22.94 66 31434 33420 56227147
Microsporidia infection 35.81 22.94 11 31489 272 56260295
Alpha haemolytic streptococcal infection 35.46 22.94 16 31484 1180 56259387
Disseminated tuberculosis 35.20 22.94 21 31479 2762 56257805
Metastatic malignant melanoma 35.09 22.94 17 31483 1473 56259094
Brain oedema 34.80 22.94 40 31460 13231 56247336
Impaired healing 34.64 22.94 4 31496 86837 56173730
Pseudomonal sepsis 34.34 22.94 19 31481 2167 56258400
Musculoskeletal pain 34.29 22.94 3 31497 81149 56179418
Palpitations 34.29 22.94 7 31493 99665 56160902
Mycobacterium kansasii infection 34.23 22.94 9 31491 124 56260443
Disseminated intravascular coagulation 34.19 22.94 46 31454 17839 56242728
Candida sepsis 33.93 22.94 16 31484 1306 56259261
Staphylococcal bacteraemia 33.82 22.94 26 31474 5183 56255384
Scedosporium infection 33.53 22.94 12 31488 482 56260085
Systemic inflammatory response syndrome 33.52 22.94 26 31474 5252 56255315
Gastrooesophageal reflux disease 32.80 22.94 4 31496 83253 56177314
Bronchitis 32.72 22.94 11 31489 112300 56148267
Chronic graft versus host disease in intestine 32.68 22.94 8 31492 81 56260486
Haemoglobin decreased 32.56 22.94 155 31345 133982 56126585
Erythema 32.34 22.94 24 31476 155915 56104652
Haematotoxicity 32.24 22.94 31 31469 8352 56252215
Diarrhoea 31.90 22.94 218 31282 638289 55622278
Chronic graft versus host disease in liver 31.31 22.94 10 31490 282 56260285
Lung consolidation 30.85 22.94 22 31478 3912 56256655
Myocarditis 30.80 22.94 31 31469 8827 56251740
Dedifferentiated liposarcoma 30.65 22.94 7 31493 51 56260516
Febrile bone marrow aplasia 30.51 22.94 27 31473 6545 56254022
Serum amyloid A protein increased 30.42 22.94 9 31491 195 56260372
Myeloid leukaemia 30.08 22.94 10 31490 321 56260246
Skin toxicity 29.78 22.94 22 31478 4131 56256436
Bronchiolitis 29.51 22.94 18 31482 2464 56258103
Idiopathic pneumonia syndrome 29.47 22.94 10 31490 342 56260225
Fungal sepsis 29.30 22.94 14 31486 1177 56259390
Gastroenteritis norovirus 28.95 22.94 16 31484 1821 56258746
Human herpesvirus 6 infection reactivation 28.23 22.94 8 31492 148 56260419
Metastases to diaphragm 28.04 22.94 6 31494 31 56260536
Sinusitis 27.99 22.94 42 31458 197539 56063028
Myalgia 27.79 22.94 20 31480 132005 56128562
Dehydration 27.45 22.94 29 31471 158796 56101771
Hilar lymphadenopathy 27.40 22.94 13 31487 1076 56259491
Adrenal haemorrhage 27.31 22.94 10 31490 429 56260138
Parainfluenzae viral bronchitis 27.30 22.94 5 31495 9 56260558
Pleural effusion 27.04 22.94 107 31393 85373 56175194
Peritoneal mesothelioma malignant 26.96 22.94 5 31495 10 56260557
Neoplasm progression 26.91 22.94 57 31443 31959 56228608
Cerebrovascular accident 26.77 22.94 11 31489 99259 56161308
Dysplasia 26.76 22.94 12 31488 872 56259695
Gastritis fungal 26.59 22.94 7 31493 97 56260470
Delayed engraftment 26.59 22.94 7 31493 97 56260470
Blister 26.38 22.94 14 31486 108873 56151694
Recurrent cancer 26.31 22.94 15 31485 1813 56258754
Growth retardation 26.25 22.94 13 31487 1182 56259385
Hypotension 26.22 22.94 234 31266 250274 56010293
Hyperhidrosis 26.07 22.94 10 31490 94078 56166489
Escherichia sepsis 26.03 22.94 21 31479 4488 56256079
Cellulitis staphylococcal 26.02 22.94 11 31489 693 56259874
Blindness cortical 25.87 22.94 10 31490 499 56260068
Sphingomonas paucimobilis infection 25.78 22.94 6 31494 48 56260519
Capillary leak syndrome 25.29 22.94 15 31485 1951 56258616
Hepatic necrosis 25 22.94 22 31478 5294 56255273
Mucosal disorder 24.88 22.94 15 31485 2011 56258556
Leukoerythroblastosis 24.87 22.94 8 31492 231 56260336
Drug interaction 24.78 22.94 50 31450 209705 56050862
B-lymphocyte count abnormal 24.58 22.94 6 31494 60 56260507
Parainfluenzae virus infection 24.58 22.94 15 31485 2055 56258512
Nephropathy toxic 24.58 22.94 27 31473 8500 56252067
Neutropenic infection 24.11 22.94 12 31488 1103 56259464
Paraparesis 24.03 22.94 15 31485 2138 56258429
Enterobacter bacteraemia 24.02 22.94 8 31492 258 56260309
Klebsiella bacteraemia 23.99 22.94 13 31487 1423 56259144
Septic embolus 23.99 22.94 11 31489 842 56259725
Gastroenteritis adenovirus 23.69 22.94 7 31493 151 56260416
Acute myeloid leukaemia refractory 23.66 22.94 6 31494 71 56260496
Loss of personal independence in daily activities 23.64 22.94 8 31492 81361 56179206
Pericarditis 23.58 22.94 16 31484 108907 56151660
Acquired gene mutation 23.58 22.94 11 31489 876 56259691
Immune thrombocytopenia 23.55 22.94 28 31472 9597 56250970
Leukaemic infiltration extramedullary 23.51 22.94 6 31494 73 56260494
Left ventricular dysfunction 23.42 22.94 30 31470 11093 56249474
Guillain-Barre syndrome 23.35 22.94 18 31482 3602 56256965
Primary mediastinal large B-cell lymphoma 23.34 22.94 5 31495 26 56260541
Hepatitis B 23.33 22.94 18 31482 3606 56256961
Venous haemorrhage 23.29 22.94 8 31492 284 56260283
Dry mouth 23.16 22.94 4 31496 64201 56196366
Ascites 22.96 22.94 59 31441 37485 56223082

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Cytokine release syndrome 1930.83 18.57 778 46639 15864 31634063
Acute graft versus host disease 1218.65 18.57 426 46991 5727 31644200
Cytomegalovirus infection 1037.63 18.57 573 46844 24134 31625793
Acute graft versus host disease in skin 966.16 18.57 337 47080 4495 31645432
Hypogammaglobulinaemia 726.94 18.57 298 47119 6329 31643598
Graft versus host disease 705.43 18.57 334 47083 10113 31639814
Febrile neutropenia 602.73 18.57 822 46595 121027 31528900
Graft versus host disease in gastrointestinal tract 583.27 18.57 213 47204 3266 31646661
Chronic graft versus host disease 566.53 18.57 222 47195 4170 31645757
Adenovirus infection 532.32 18.57 217 47200 4537 31645390
Venoocclusive liver disease 488.14 18.57 233 47184 7179 31642748
Graft versus host disease in skin 475.16 18.57 185 47232 3412 31646515
Acute graft versus host disease in intestine 465.97 18.57 166 47251 2360 31647567
Neurotoxicity 461.84 18.57 293 47124 15933 31633994
Cystitis haemorrhagic 457.53 18.57 201 47216 5088 31644839
Epstein-Barr virus infection 456.14 18.57 218 47199 6735 31643192
Mucosal inflammation 414.16 18.57 371 47046 34056 31615871
Progressive multifocal leukoencephalopathy 398.15 18.57 218 47199 8995 31640932
Cytopenia 396.00 18.57 231 47186 10779 31639148
Cytomegalovirus infection reactivation 391.39 18.57 165 47252 3764 31646163
Immune effector cell-associated neurotoxicity syndrome 375.89 18.57 141 47276 2338 31647589
Pyrexia 375.32 18.57 1148 46269 302692 31347235
BK virus infection 356.42 18.57 167 47250 4928 31644999
Product use in unapproved indication 352.92 18.57 574 46843 98597 31551330
Myelodysplastic syndrome 326.12 18.57 253 47164 18998 31630929
Human herpesvirus 6 infection 313.88 18.57 116 47301 1841 31648086
Haemophagocytic lymphohistiocytosis 302.96 18.57 199 47218 11479 31638448
Post transplant lymphoproliferative disorder 299.64 18.57 157 47260 5919 31644008
Acute myeloid leukaemia recurrent 283.80 18.57 108 47309 1866 31648061
Venoocclusive disease 275.45 18.57 115 47302 2557 31647370
Cytomegalovirus viraemia 273.72 18.57 153 47264 6572 31643355
Thrombotic microangiopathy 266.33 18.57 169 47248 9182 31640745
Posterior reversible encephalopathy syndrome 246.32 18.57 161 47256 9206 31640721
Acute lymphocytic leukaemia recurrent 243.85 18.57 111 47306 3059 31646868
Lymphocyte count decreased 241.21 18.57 219 47198 20430 31629497
Diffuse large B-cell lymphoma 235.75 18.57 152 47265 8489 31641438
Neutropenia 235.24 18.57 594 46823 139770 31510157
Acute myeloid leukaemia 233.88 18.57 206 47211 18466 31631461
Bone marrow failure 215.98 18.57 237 47180 27771 31622156
Multiple organ dysfunction syndrome 214.64 18.57 374 47043 67829 31582098
Acute graft versus host disease in liver 213.14 18.57 80 47337 1328 31648599
Chronic graft versus host disease in skin 204.63 18.57 69 47348 823 31649104
Transplant failure 189.84 18.57 93 47324 3033 31646894
Leukaemia recurrent 185.71 18.57 75 47342 1527 31648400
Bronchopulmonary aspergillosis 179.94 18.57 155 47262 13479 31636448
Fatigue 177.89 18.57 145 47272 335061 31314866
Autoimmune haemolytic anaemia 175.45 18.57 97 47320 4075 31645852
Pancytopenia 170.14 18.57 392 47025 86924 31563003
Fall 169.36 18.57 36 47381 186053 31463874
Engraftment syndrome 168.62 18.57 60 47357 849 31649078
Chronic lymphocytic leukaemia 159.90 18.57 96 47321 4720 31645207
Viral haemorrhagic cystitis 157.59 18.57 59 47358 972 31648955
Dizziness 147.26 18.57 57 47360 199090 31450837
Off label use 144.29 18.57 949 46468 346325 31303602
Dyspnoea 144.10 18.57 182 47235 343297 31306630
Bacteraemia 140.74 18.57 152 47265 17482 31632445
Epstein-Barr viraemia 138.97 18.57 54 47363 989 31648938
JC virus infection 135.25 18.57 64 47353 1930 31647997
Cystitis viral 129.68 18.57 43 47374 485 31649442
Asthenia 129.57 18.57 89 47328 224666 31425261
Arthralgia 126.55 18.57 35 47382 151389 31498538
Haematocrit decreased 124.68 18.57 187 47230 29874 31620053
Chronic lymphocytic leukaemia recurrent 123.11 18.57 39 47378 376 31649551
Completed suicide 122.63 18.57 3 47414 91511 31558416
Drug interaction 122.31 18.57 81 47336 208462 31441465
B-cell type acute leukaemia 118.29 18.57 36 47381 300 31649627
Neutrophil count decreased 115.25 18.57 230 47187 46164 31603763
Myocardial infarction 113.85 18.57 17 47400 113437 31536490
Herpes simplex 113.66 18.57 80 47337 5165 31644762
Aspergillus infection 113.02 18.57 111 47306 11417 31638510
Toxoplasmosis 111.19 18.57 49 47368 1248 31648679
Pain 108.86 18.57 73 47344 186686 31463241
Graft versus host disease in liver 106.14 18.57 46 47371 1124 31648803
Pneumonia cytomegaloviral 105.73 18.57 61 47356 2783 31647144
Rhinovirus infection 103.92 18.57 65 47352 3440 31646487
Encephalitis viral 103.25 18.57 45 47372 1115 31648812
Lymphadenopathy 99.18 18.57 156 47261 25965 31623962
Second primary malignancy 99.02 18.57 83 47334 6949 31642978
Epstein-Barr virus associated lymphoproliferative disorder 98.63 18.57 50 47367 1756 31648171
Human herpesvirus 6 encephalitis 97.67 18.57 29 47388 220 31649707
Microsporidia infection 95.99 18.57 36 47381 596 31649331
Constipation 95.76 18.57 33 47384 123958 31525969
Bone marrow transplant rejection 94.61 18.57 27 47390 175 31649752
Encephalitis 93.00 18.57 79 47338 6736 31643191
Fusarium infection 93.00 18.57 41 47376 1045 31648882
Epstein-Barr virus infection reactivation 92.91 18.57 38 47379 800 31649127
Diffuse large B-cell lymphoma recurrent 92.83 18.57 57 47360 2918 31647009
Fungal infection 91.68 18.57 111 47306 14440 31635487
Anxiety 90.49 18.57 14 47403 91019 31558908
Pain in extremity 89.60 18.57 31 47386 116172 31533755
Overdose 88.91 18.57 11 47406 84653 31565274
Thrombocytopenia 88.57 18.57 435 46982 142312 31507615
Encephalitis cytomegalovirus 87.61 18.57 32 47385 490 31649437
Weight decreased 86.04 18.57 68 47349 159884 31490043
Insomnia 82.84 18.57 20 47397 94816 31555111
Stenotrophomonas infection 82.15 18.57 45 47372 1855 31648072
Mucormycosis 81.03 18.57 67 47350 5503 31644424
Malaise 80.58 18.57 80 47337 168431 31481496
Pseudomonas infection 80.17 18.57 92 47325 11309 31638618
Respiratory failure 80.01 18.57 332 47085 101117 31548810
Death 79.20 18.57 276 47141 360293 31289634
Nausea 78.69 18.57 220 47197 307727 31342200
Sepsis 78.43 18.57 440 46977 151489 31498438
Aplastic anaemia 76.36 18.57 81 47336 9122 31640805
Chest pain 76.13 18.57 40 47377 116917 31533010
Cytomegalovirus test positive 75.83 18.57 54 47363 3551 31646376
Pneumonia fungal 75.57 18.57 68 47349 6261 31643666
Lymphopenia 75.51 18.57 100 47317 14229 31635698
Chronic graft versus host disease in liver 74.86 18.57 26 47391 341 31649586
Pneumatosis intestinalis 74.42 18.57 54 47363 3657 31646270
Septic shock 73.57 18.57 242 47175 65916 31584011
Pruritus 72.76 18.57 49 47368 125118 31524809
Cerebral aspergillosis 71.41 18.57 37 47380 1361 31648566
Cytomegalovirus chorioretinitis 71.30 18.57 51 47366 3377 31646550
Respiratory syncytial virus infection 70.65 18.57 53 47364 3778 31646149
Systemic mycosis 69.92 18.57 37 47380 1422 31648505
Nasopharyngitis 69.46 18.57 7 47410 63238 31586689
Varicella zoster virus infection 69.12 18.57 38 47379 1578 31648349
Idiopathic pneumonia syndrome 68.37 18.57 22 47395 224 31649703
Hypoxia 67.97 18.57 197 47220 50116 31599811
Minimal residual disease 67.41 18.57 24 47393 340 31649587
Parainfluenzae virus infection 66.58 18.57 43 47374 2406 31647521
B-cell aplasia 66.04 18.57 18 47399 96 31649831
Stem cell transplant 65.85 18.57 40 47377 2008 31647919
Cerebral toxoplasmosis 64.48 18.57 36 47381 1541 31648386
White blood cell count decreased 64.22 18.57 280 47137 87118 31562809
Blood pressure increased 63.54 18.57 20 47397 79613 31570314
Gait disturbance 62.66 18.57 19 47398 77476 31572451
Engraft failure 62.40 18.57 24 47393 427 31649500
Encephalopathy 61.15 18.57 144 47273 32330 31617597
Dehydration 61.08 18.57 53 47364 119058 31530869
Toxicity to various agents 60.59 18.57 112 47305 181375 31468552
Platelet count decreased 59.71 18.57 324 47093 110111 31539816
Syncope 58.64 18.57 27 47390 85155 31564772
Muscle spasms 58.50 18.57 15 47402 68303 31581624
Bacterial infection 57.70 18.57 86 47331 13653 31636274
Chronic graft versus host disease in intestine 56.08 18.57 19 47398 230 31649697
Joint swelling 55.94 18.57 7 47410 53424 31596503
Diarrhoea 55.80 18.57 305 47112 352104 31297823
Meningoencephalitis herpetic 55.15 18.57 26 47391 777 31649150
Depression 54.87 18.57 34 47383 90781 31559146
Peripheral swelling 54.22 18.57 17 47400 67848 31582079
Bacterial sepsis 53.98 18.57 50 47367 4778 31645149
Feeling abnormal 53.90 18.57 10 47407 56992 31592935
Infection 53.84 18.57 254 47163 81677 31568250
Drug hypersensitivity 53.18 18.57 21 47396 72578 31577349
Blood glucose increased 53.09 18.57 13 47404 61070 31588857
Leukoencephalopathy 52.76 18.57 45 47372 3857 31646070
Hypoglycaemia 52.55 18.57 7 47410 50939 31598988
Aphasia 52.10 18.57 101 47316 19830 31630097
Toxic leukoencephalopathy 51.95 18.57 19 47398 292 31649635
Graft versus host disease in eye 51.76 18.57 18 47399 237 31649690
Asthma 51.61 18.57 3 47414 42608 31607319
Pneumonia respiratory syncytial viral 51.31 18.57 25 47392 805 31649122
Polyomavirus viraemia 50.89 18.57 24 47393 718 31649209
Rhabdomyolysis 50.66 18.57 16 47401 63565 31586362
Pre-engraftment immune reaction 49.84 18.57 14 47403 85 31649842
Foetal exposure during pregnancy 49.14 18.57 3 47414 40873 31609054
Nephropathy toxic 49.02 18.57 72 47345 11281 31638646
Back pain 48.82 18.57 55 47362 109358 31540569
Rash 48.39 18.57 148 47269 201338 31448589
Hepatic failure 48.02 18.57 132 47285 32570 31617357
Tumour lysis syndrome 47.81 18.57 84 47333 15301 31634626
Chronic lymphocytic leukaemia refractory 47.64 18.57 14 47403 102 31649825
Vomiting 47.32 18.57 174 47243 223799 31426128
Adenoviral haemorrhagic cystitis 46.67 18.57 19 47398 395 31649532
Cytomegalovirus hepatitis 46.41 18.57 19 47398 401 31649526
Hepatitis B reactivation 46.41 18.57 40 47377 3478 31646449
Cerebrovascular accident 44.98 18.57 32 47385 79452 31570475
Abdominal discomfort 44.76 18.57 11 47406 51556 31598371
Chronic obstructive pulmonary disease 44.73 18.57 7 47410 45159 31604768
Serum ferritin increased 44.58 18.57 49 47368 5743 31644184
Chronic lymphocytic leukaemia transformation 44.55 18.57 15 47402 178 31649749
Capillary leak syndrome 44.30 18.57 31 47386 1982 31647945
Adenovirus reactivation 44.25 18.57 15 47402 182 31649745
Pulmonary embolism 43.47 18.57 35 47382 81611 31568316
Out of specification test results 43.47 18.57 10 47407 22 31649905
B-lymphocyte count abnormal 43.34 18.57 9 47408 9 31649918
Disseminated intravascular coagulation 43.01 18.57 95 47322 20442 31629485
Autoimmune lymphoproliferative syndrome 42.70 18.57 14 47403 152 31649775
Staphylococcal infection 42.37 18.57 121 47296 30511 31619416
5q minus syndrome 41.97 18.57 14 47403 161 31649766
Enterococcal infection 41.55 18.57 58 47359 8673 31641254
Aggression 41.27 18.57 4 47413 37287 31612640
Weight increased 41.19 18.57 38 47379 82909 31567018
Chimerism 41.17 18.57 15 47402 228 31649699
Neurological decompensation 41.16 18.57 33 47384 2594 31647333
Myelosuppression 40.70 18.57 77 47340 14843 31635084
Blood creatine phosphokinase increased 40.47 18.57 7 47410 41967 31607960
Hyperkalaemia 40.39 18.57 23 47394 64328 31585599
Pneumocystis jirovecii pneumonia 40.01 18.57 86 47331 18165 31631762
Blood stem cell transplant failure 39.78 18.57 17 47400 401 31649526
Intentional product misuse 39.65 18.57 5 47412 37946 31611981
Hyperhidrosis 39.64 18.57 26 47391 67367 31582560
Viraemia 38.63 18.57 23 47394 1113 31648814
Candida infection 38.42 18.57 79 47338 16179 31633748
Malignant neoplasm progression 38.18 18.57 225 47192 78773 31571154
Viral sinusitis 37.94 18.57 11 47406 76 31649851
Suicidal ideation 37.55 18.57 5 47412 36401 31613526
Dyspepsia 37.36 18.57 3 47414 32550 31617377
Myelitis 37.24 18.57 20 47397 792 31649135
Klebsiella sepsis 37.21 18.57 27 47390 1828 31648099
Leukaemic infiltration 37.05 18.57 12 47405 125 31649802
Mucosal disorder 37.01 18.57 25 47392 1509 31648418
Condition aggravated 36.89 18.57 124 47293 163885 31486042
Meningomyelitis herpes 36.64 18.57 9 47408 29 31649898
Decreased appetite 36.43 18.57 113 47304 153104 31496823
Hyponatraemia 36.42 18.57 34 47383 73765 31576162
Glomerulosclerosis 36.37 18.57 19 47398 711 31649216
Coronary artery disease 36.00 18.57 12 47405 46075 31603852
Haemolysis 35.94 18.57 49 47368 7167 31642760
Organic brain syndrome 35.75 18.57 14 47403 262 31649665
Acute myocardial infarction 35.13 18.57 16 47401 50807 31599120
Acute respiratory distress syndrome 34.98 18.57 98 47319 24442 31625485
Obliterative bronchiolitis 34.90 18.57 22 47395 1180 31648747
Acute lymphocytic leukaemia 34.80 18.57 34 47383 3472 31646455
Enterococcal sepsis 34.65 18.57 24 47393 1509 31648418
Post transplant distal limb syndrome 34.48 18.57 14 47403 289 31649638
Meningitis cryptococcal 33.91 18.57 28 47389 2295 31647632
Staphylococcal sepsis 33.88 18.57 54 47363 9083 31640844
Respiratory tract infection fungal 33.87 18.57 18 47399 698 31649229
Musculoskeletal stiffness 33.63 18.57 10 47407 41315 31608612
Pulmonary haemorrhage 33.17 18.57 55 47362 9560 31640367
Blood fibrinogen decreased 33.07 18.57 21 47396 1141 31648786
Bradycardia 32.97 18.57 33 47384 69294 31580633
Cardiac disorder 32.82 18.57 9 47408 39205 31610722
Transplant rejection 32.78 18.57 55 47362 9653 31640274
Urticaria 32.74 18.57 23 47394 57494 31592433
Neutropenic sepsis 32.68 18.57 63 47354 12316 31637611
Chloroma 32.64 18.57 16 47401 522 31649405
Candida sepsis 32.62 18.57 21 47396 1168 31648759
Hypoaesthesia 32.42 18.57 22 47395 56000 31593927
Unevaluable event 32.01 18.57 4 47413 30571 31619356
Gastrooesophageal reflux disease 31.89 18.57 6 47411 33865 31616062
Loss of consciousness 31.21 18.57 42 47375 77313 31572614
Disseminated toxoplasmosis 31.03 18.57 8 47409 33 31649894
Musculoskeletal pain 30.99 18.57 4 47413 29824 31620103
Poikiloderma 30.63 18.57 11 47406 160 31649767
Apoptosis 30.57 18.57 12 47405 226 31649701
Splenomegaly 30.38 18.57 65 47352 13684 31636243
Infection reactivation 30.23 18.57 21 47396 1327 31648600
Acute erythroid leukaemia 30.20 18.57 11 47406 167 31649760
Cytokine storm 30.16 18.57 16 47401 618 31649309
Aplasia pure red cell 30.16 18.57 40 47377 5697 31644230
Diabetes mellitus 30.04 18.57 13 47404 42543 31607384
Skin toxicity 29.97 18.57 34 47383 4125 31645802
Escherichia sepsis 29.92 18.57 34 47383 4133 31645794
Mucosal toxicity 29.77 18.57 12 47405 243 31649684
Clostridium difficile infection 29.71 18.57 74 47343 17205 31632722
Angioedema 29.51 18.57 7 47410 33611 31616316
Rubulavirus test positive 29.41 18.57 6 47411 5 31649922
Clostridium difficile colitis 29.41 18.57 65 47352 13991 31635936
Somnolence 29.20 18.57 66 47351 99379 31550548
Plasma cell myeloma 29.14 18.57 25 47392 56506 31593421
Oedema peripheral 29.03 18.57 77 47340 109762 31540165
Herpes virus infection 28.97 18.57 27 47390 2600 31647327
Evans syndrome 28.93 18.57 12 47405 262 31649665
Post-depletion B-cell recovery 28.89 18.57 6 47411 6 31649921
Fungal sepsis 28.83 18.57 17 47400 808 31649119
Stomatitis 28.65 18.57 126 47291 39312 31610615
Human herpesvirus 6 infection reactivation 27.94 18.57 10 47407 144 31649783
Pulmonary alveolar haemorrhage 27.90 18.57 42 47375 6724 31643203
Haemoglobin decreased 27.80 18.57 274 47143 112401 31537526
Treatment noncompliance 27.79 18.57 3 47414 25681 31624246
Chest discomfort 27.76 18.57 20 47397 49349 31600578
Lymphocytosis 27.66 18.57 24 47393 2105 31647822
Lymphoproliferative disorder 27.25 18.57 26 47391 2579 31647348
Polymyositis 27.04 18.57 20 47397 1395 31648532
Achromobacter infection 27.02 18.57 8 47409 60 31649867
Meningeal neoplasm 26.91 18.57 8 47409 61 31649866
Refractory anaemia with an excess of blasts 26.87 18.57 13 47404 412 31649515
Urge incontinence 26.87 18.57 14 47403 521 31649406
Stenotrophomonas sepsis 26.56 18.57 9 47408 109 31649818
CNS ventriculitis 26.53 18.57 11 47406 240 31649687
Bronchiolitis obliterans syndrome 26.53 18.57 10 47407 168 31649759
Meningitis tuberculous 26.51 18.57 15 47402 659 31649268
Norovirus infection 26.46 18.57 8 47409 65 31649862
Coronavirus infection 26.36 18.57 30 47387 3653 31646274
Angina pectoris 26.36 18.57 6 47411 29635 31620292
Pleural effusion 26.27 18.57 197 47220 74723 31575204
Chronic kidney disease 26.17 18.57 12 47405 37963 31611964
Gastrointestinal infection 26.06 18.57 34 47383 4766 31645161
Eccrine squamous syringometaplasia 26.06 18.57 7 47410 35 31649892
Neoplasm progression 26.04 18.57 78 47339 20194 31629733
NPM1 gene mutation 25.98 18.57 9 47408 117 31649810
Immune thrombocytopenia 25.88 18.57 46 47371 8452 31641475
International normalised ratio increased 25.85 18.57 18 47399 45205 31604722
Kidney fibrosis 25.84 18.57 23 47394 2087 31647840
Neoplasm recurrence 25.80 18.57 23 47394 2091 31647836
Staphylococcal bacteraemia 25.80 18.57 43 47374 7505 31642422
Dysphagia 25.70 18.57 29 47388 57647 31592280
Reticulocytosis 25.64 18.57 11 47406 262 31649665
Roseolovirus test positive 25.55 18.57 8 47409 74 31649853
Autoimmune neutropenia 25.52 18.57 11 47406 265 31649662
Hepatic vein occlusion 25.51 18.57 9 47408 124 31649803
Arthritis 25.46 18.57 5 47412 27380 31622547
Heart rate increased 25.36 18.57 15 47402 41095 31608832
Retinopathy haemorrhagic 25.28 18.57 7 47410 40 31649887
Viral myocarditis 25.25 18.57 9 47408 128 31649799
Dry skin 25.11 18.57 4 47413 25477 31624450
Myeloid leukaemia 25.08 18.57 12 47405 371 31649556
Bladder hypertrophy 25.02 18.57 14 47403 602 31649325
Haemolytic anaemia 24.81 18.57 49 47368 9747 31640180
Pneumoretroperitoneum 24.63 18.57 9 47408 138 31649789
Enterocolitis viral 24.56 18.57 8 47409 85 31649842
Dysbiosis 24.44 18.57 12 47405 393 31649534
Retinitis viral 24.31 18.57 8 47409 88 31649839
Brain sarcoma 24.19 18.57 7 47410 48 31649879
Autoimmune pancytopenia 24.14 18.57 8 47409 90 31649837
Toxic erythema of chemotherapy 24.06 18.57 8 47409 91 31649836
Hypokalaemia 23.80 18.57 27 47390 53547 31596380
Palpitations 23.72 18.57 11 47406 34572 31615355
Stenotrophomonas bacteraemia 23.59 18.57 7 47410 53 31649874
Cytomegalovirus colitis 23.58 18.57 24 47393 2574 31647353
Fungaemia 23.56 18.57 23 47394 2346 31647581
Primary amyloidosis 23.56 18.57 9 47408 157 31649770
Mobility decreased 23.56 18.57 6 47411 27463 31622464
Cryptosporidiosis infection 23.50 18.57 12 47405 428 31649499
Pneumonia viral 23.39 18.57 25 47392 2839 31647088
Flushing 23.25 18.57 8 47409 30120 31619807
Aplasia 23.17 18.57 30 47387 4173 31645754
Abdominal pain 23.16 18.57 126 47291 145826 31504101
Hyperfibrinogenaemia 23.14 18.57 7 47410 57 31649870
Cardio-respiratory arrest 23.05 18.57 26 47391 51700 31598227
Bordetella infection 23.03 18.57 8 47409 105 31649822
Cerebellar tumour 22.82 18.57 7 47410 60 31649867
Multisystem inflammatory syndrome in children 22.77 18.57 5 47412 8 31649919
Rectal haemorrhage 22.74 18.57 13 47404 36291 31613636
Gastroenteritis norovirus 22.65 18.57 18 47399 1397 31648530
Bacillus infection 22.57 18.57 10 47407 258 31649669
Swelling 22.52 18.57 14 47403 37344 31612583
Sleep disorder 22.13 18.57 6 47411 26342 31623585
Chronic myeloid leukaemia recurrent 21.98 18.57 9 47408 190 31649737
Arrhythmia 21.96 18.57 11 47406 33066 31616861
Contusion 21.90 18.57 11 47406 33017 31616910
Enterococcal bacteraemia 21.87 18.57 19 47398 1669 31648258
Graft versus host disease in lung 21.59 18.57 12 47405 509 31649418
Pneumomediastinum 21.56 18.57 21 47396 2136 31647791
Oxygen saturation decreased 21.55 18.57 25 47392 49090 31600837
Refractory cytopenia with multilineage dysplasia 21.30 18.57 8 47409 133 31649794
Balance disorder 21.24 18.57 15 47402 37407 31612520
Haptoglobin decreased 21.19 18.57 12 47405 528 31649399
Pseudomonal sepsis 21.14 18.57 25 47392 3171 31646756
Premature ageing 21.03 18.57 7 47410 80 31649847
Wheezing 20.99 18.57 14 47403 35972 31613955
Headache 20.91 18.57 175 47242 183477 31466450
Transplantation associated food allergy 20.88 18.57 6 47411 40 31649887
Hydrocephalus 20.83 18.57 30 47387 4615 31645312
Abnormal behaviour 20.83 18.57 5 47412 23823 31626104
Campylobacter infection 20.81 18.57 14 47403 839 31649088
Complications of bone marrow transplant 20.72 18.57 9 47408 221 31649706
Pneumonia parainfluenzae viral 20.71 18.57 8 47409 144 31649783
Gallbladder adenocarcinoma 20.62 18.57 5 47412 15 31649912
Spirochaetal infection 20.62 18.57 5 47412 15 31649912
Adenomatous polyposis coli 20.36 18.57 8 47409 151 31649776
Cerebral fungal infection 20.32 18.57 9 47408 232 31649695
Drug resistance 20.23 18.57 79 47338 23374 31626553
Cardiac arrest 20.22 18.57 67 47350 88995 31560932
Prostate cancer 20.15 18.57 16 47401 37585 31612342
Arthritis fungal 20.14 18.57 7 47410 92 31649835
Neutrophil Pelger-Huet anomaly present 20.07 18.57 9 47408 239 31649688
Disseminated Bacillus Calmette-Guerin infection 19.87 18.57 9 47408 245 31649682
Metabolic acidosis 19.79 18.57 18 47399 39559 31610368
Thrombosis 19.79 18.57 23 47394 45128 31604799
Organising pneumonia 19.65 18.57 32 47385 5478 31644449
Citrobacter infection 19.63 18.57 11 47406 474 31649453
Urinary tract infection 19.47 18.57 55 47362 76814 31573113
Haematoma 19.35 18.57 6 47411 24133 31625794
Device related infection 19.34 18.57 61 47356 16238 31633689
Non-Hodgkin's lymphoma recurrent 19.32 18.57 5 47412 21 31649906
Peritoneal lesion 19.30 18.57 7 47410 105 31649822
Cardiac failure congestive 19.23 18.57 58 47359 79329 31570598
Retinal infiltrates 19.13 18.57 5 47412 22 31649905
Myelopathy 19.05 18.57 20 47397 2225 31647702
Myalgia 19.04 18.57 56 47361 77202 31572725
Hypersensitivity 18.91 18.57 34 47383 55709 31594218
Gait inability 18.88 18.57 3 47414 19141 31630786
Paraparesis 18.84 18.57 18 47399 1788 31648139
Epstein-Barr virus test positive 18.84 18.57 11 47406 513 31649414
Meningitis viral 18.59 18.57 13 47404 830 31649097
Erythema 18.59 18.57 60 47357 80345 31569582

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Cytokine release syndrome 3498.14 18.04 1232 71956 25235 70830021
Acute graft versus host disease 2305.02 18.04 702 72486 8860 70846396
Cytomegalovirus infection 2066.11 18.04 945 72243 38813 70816443
Acute graft versus host disease in skin 1647.63 18.04 507 72681 6630 70848626
Graft versus host disease 1455.47 18.04 557 72631 14466 70840790
Febrile neutropenia 1267.33 18.04 1291 71897 203027 70652229
Chronic graft versus host disease 1166.58 18.04 385 72803 6385 70848871
Adenovirus infection 1126.30 18.04 388 72800 7380 70847876
Hypogammaglobulinaemia 1039.88 18.04 406 72782 11132 70844124
Graft versus host disease in gastrointestinal tract 968.13 18.04 324 72864 5620 70849636
Venoocclusive liver disease 959.69 18.04 375 72813 10303 70844953
Graft versus host disease in skin 949.29 18.04 315 72873 5315 70849941
Neurotoxicity 865.24 18.04 478 72710 29348 70825908
Product use in unapproved indication 843.37 18.04 1053 72135 206425 70648831
Cytomegalovirus infection reactivation 831.31 18.04 299 72889 6482 70848774
Cystitis haemorrhagic 780.02 18.04 304 72884 8289 70846967
Acute graft versus host disease in intestine 775.49 18.04 246 72942 3570 70851686
Epstein-Barr virus infection 758.65 18.04 337 72851 12861 70842395
Immune effector cell-associated neurotoxicity syndrome 724.67 18.04 236 72952 3742 70851514
Human herpesvirus 6 infection 686.08 18.04 238 72950 4621 70850635
Pyrexia 657.37 18.04 1725 71463 605227 70250029
Myelodysplastic syndrome 624.90 18.04 387 72801 29398 70825858
Mucosal inflammation 624.47 18.04 535 72653 67315 70787941
BK virus infection 615.07 18.04 251 72937 7738 70847518
Post transplant lymphoproliferative disorder 611.64 18.04 271 72917 10274 70844982
Thrombotic microangiopathy 592.72 18.04 313 72875 17535 70837721
Cytopenia 590.09 18.04 309 72879 17014 70838242
Cytomegalovirus viraemia 581.88 18.04 270 72918 11415 70843841
Progressive multifocal leukoencephalopathy 573.81 18.04 314 72874 18900 70836356
Acute myeloid leukaemia 542.41 18.04 359 72829 30581 70824675
Acute lymphocytic leukaemia recurrent 511.43 18.04 192 72996 4712 70850544
Haemophagocytic lymphohistiocytosis 497.50 18.04 288 72900 19324 70835932
Acute myeloid leukaemia recurrent 491.42 18.04 165 73023 2889 70852367
Neutropenia 447.80 18.04 884 72304 256272 70598984
Multiple organ dysfunction syndrome 443.51 18.04 553 72635 107962 70747294
Lymphocyte count decreased 395.69 18.04 341 72847 43198 70812058
Posterior reversible encephalopathy syndrome 381.95 18.04 264 72924 24138 70831118
Pain 369.60 18.04 97 73091 628719 70226537
Viral haemorrhagic cystitis 367.72 18.04 117 73071 1714 70853542
Acute graft versus host disease in liver 366.05 18.04 116 73072 1676 70853580
Pancytopenia 360.42 18.04 596 72592 150511 70704745
Chronic graft versus host disease in skin 358.47 18.04 109 73079 1362 70853894
Venoocclusive disease 350.99 18.04 140 73048 4060 70851196
Bronchopulmonary aspergillosis 347.13 18.04 235 72953 20767 70834489
Transplant failure 340.09 18.04 136 73052 3971 70851285
Diffuse large B-cell lymphoma 312.73 18.04 186 73002 13116 70842140
Bone marrow failure 310.41 18.04 314 72874 48696 70806560
Fatigue 294.49 18.04 252 72936 824067 70031189
Rheumatoid arthritis 284.88 18.04 3 73185 291802 70563454
Chronic lymphocytic leukaemia recurrent 283.59 18.04 75 73113 540 70854716
Fall 283.54 18.04 57 73131 444039 70411217
Autoimmune haemolytic anaemia 280.46 18.04 144 73044 7602 70847654
Encephalitis viral 274.37 18.04 101 73087 2341 70852915
Arthralgia 264.27 18.04 95 73093 503295 70351961
Chronic lymphocytic leukaemia 264.06 18.04 126 73062 5672 70849584
Neutrophil count decreased 263.06 18.04 375 72813 83181 70772075
Thrombocytopenia 256.39 18.04 679 72509 238431 70616825
Herpes simplex 256.10 18.04 154 73034 11078 70844178
Leukaemia recurrent 254.69 18.04 99 73089 2676 70852580
Aspergillus infection 253.33 18.04 182 73006 17686 70837570
Bacteraemia 253.03 18.04 223 72965 29086 70826170
Off label use 251.69 18.04 1462 71726 741598 70113658
Dizziness 249.78 18.04 84 73104 464057 70391199
Engraftment syndrome 242.45 18.04 78 73110 1186 70854070
Premature menopause 238.44 18.04 64 73124 491 70854765
JC virus infection 231.08 18.04 99 73089 3452 70851804
Dyspnoea 227.53 18.04 277 72911 769783 70085473
Cystitis viral 221.07 18.04 63 73125 617 70854639
Joint swelling 219.08 18.04 10 73178 253201 70602055
Fusarium infection 210.83 18.04 76 73112 1656 70853600
B-cell type acute leukaemia 198.76 18.04 54 73134 436 70854820
Toxoplasmosis 197.44 18.04 81 73107 2529 70852727
Nasopharyngitis 194.78 18.04 8 73180 222198 70633058
Pain in extremity 193.47 18.04 50 73138 328032 70527224
Sepsis 193.34 18.04 623 72565 243922 70611334
Systemic mycosis 193.27 18.04 79 73109 2443 70852813
Haematocrit decreased 192.09 18.04 265 72923 56993 70798263
Epstein-Barr viraemia 188.60 18.04 72 73116 1851 70853405
Platelet count decreased 184.69 18.04 500 72688 177722 70677534
Nausea 183.03 18.04 379 72809 851709 70003547
Second primary malignancy 182.86 18.04 132 73056 12919 70842337
Drug hypersensitivity 179.69 18.04 28 73160 262431 70592825
White blood cell count decreased 174.96 18.04 476 72712 169665 70685591
Abdominal discomfort 174.81 18.04 12 73176 214646 70640610
Pruritus 174.81 18.04 69 73119 345491 70509765
Pneumonia cytomegaloviral 174.46 18.04 88 73100 4473 70850783
Malaise 173.72 18.04 117 73071 432815 70422441
Respiratory failure 173.44 18.04 472 72716 168263 70686993
Asthenia 170.24 18.04 134 73054 457532 70397724
Leukoencephalopathy 168.85 18.04 101 73087 7193 70848063
Pre-engraftment immune reaction 168.83 18.04 44 73144 297 70854959
Epstein-Barr virus infection reactivation 167.73 18.04 62 73126 1454 70853802
Septic shock 166.74 18.04 362 72826 111896 70743360
Human herpesvirus 6 encephalitis 161.18 18.04 46 73142 453 70854803
Rhinovirus infection 160.47 18.04 95 73093 6638 70848618
Peripheral swelling 160.20 18.04 26 73162 236537 70618719
Cytomegalovirus chorioretinitis 159.26 18.04 87 73101 5211 70850045
Epstein-Barr virus associated lymphoproliferative disorder 157.51 18.04 74 73114 3215 70852041
Bacterial sepsis 156.84 18.04 98 73090 7549 70847707
Encephalitis 156.07 18.04 122 73066 13463 70841793
Diffuse large B-cell lymphoma recurrent 153.61 18.04 74 73114 3402 70851854
Stem cell transplant 151.43 18.04 74 73114 3511 70851745
Cytomegalovirus test positive 150.66 18.04 85 73103 5423 70849833
Lymphopenia 147.65 18.04 161 73027 27198 70828058
Graft versus host disease in liver 145.93 18.04 57 73131 1561 70853695
Meningoencephalitis herpetic 142.27 18.04 58 73130 1781 70853475
Pseudomonas infection 141.36 18.04 133 73055 18861 70836395
Anxiety 140.98 18.04 28 73160 220302 70634954
Alopecia 140.87 18.04 19 73169 198471 70656785
Malignant neoplasm progression 140.82 18.04 356 72832 121383 70733873
Constipation 140.35 18.04 43 73145 252395 70602861
Fungal infection 140.31 18.04 183 73005 37284 70817972
Microsporidia infection 138.48 18.04 47 73141 851 70854405
Aplastic anaemia 135.95 18.04 123 73065 16593 70838663
Pneumonia fungal 135.65 18.04 99 73089 9854 70845402
Viraemia 134.75 18.04 61 73127 2431 70852825
Hypoxia 134.04 18.04 297 72891 93047 70762209
Arthropathy 132.83 18.04 5 73183 150052 70705204
Engraft failure 131.56 18.04 42 73146 622 70854634
Overdose 131.17 18.04 12 73176 169733 70685523
Encephalopathy 130.67 18.04 231 72957 61430 70793826
Bone marrow transplant rejection 129.51 18.04 34 73154 237 70855019
Headache 128.71 18.04 253 72935 580152 70275104
Minimal residual disease 127.98 18.04 37 73151 383 70854873
Mucormycosis 126.05 18.04 87 73101 7927 70847329
Cerebral toxoplasmosis 125.56 18.04 55 73133 2025 70853231
Drug interaction 123.43 18.04 127 73061 381314 70473942
Vomiting 121.86 18.04 270 72918 592841 70262415
Adenoviral hepatitis 121.62 18.04 42 73146 803 70854453
Contraindicated product administered 120.84 18.04 4 73184 134608 70720648
Blood pressure increased 120.50 18.04 24 73164 188493 70666763
Myocardial infarction 120.45 18.04 17 73171 171628 70683628
Insomnia 119.44 18.04 38 73150 217768 70637488
Swelling 118.45 18.04 25 73163 188514 70666742
Lymphadenopathy 118.18 18.04 194 72994 48597 70806659
Hypersensitivity 117.60 18.04 45 73143 229767 70625489
Synovitis 115.43 18.04 4 73184 129224 70726032
Musculoskeletal stiffness 115.36 18.04 10 73178 147750 70707506
Chronic graft versus host disease in liver 114.85 18.04 37 73151 565 70854691
Varicella zoster virus infection 113.82 18.04 64 73124 4056 70851200
Staphylococcal infection 111.78 18.04 199 72989 53205 70802051
Adenovirus reactivation 111.59 18.04 32 73156 321 70854935
Weight increased 109.03 18.04 57 73131 242274 70612982
Back pain 109.00 18.04 73 73115 271079 70584177
Encephalitis cytomegalovirus 108.84 18.04 41 73147 1015 70854241
Respiratory syncytial virus infection 108.55 18.04 78 73110 7577 70847679
Therapeutic product effect decreased 108.14 18.04 11 73177 143007 70712249
Asthma 106.98 18.04 4 73184 120789 70734467
Depression 106.83 18.04 36 73152 198938 70656318
Drug intolerance 106.18 18.04 50 73138 225637 70629619
Feeling abnormal 104.92 18.04 12 73176 142307 70712949
Condition aggravated 104.90 18.04 175 73013 427460 70427796
Idiopathic pneumonia syndrome 104.83 18.04 34 73154 531 70854725
Drug resistance 100.91 18.04 158 73030 38032 70817224
Enterococcal infection 100.73 18.04 98 73090 14484 70840772
Tumour lysis syndrome 97.09 18.04 115 73073 21245 70834011
Rash 96.35 18.04 243 72945 510319 70344937
Gait disturbance 95.09 18.04 36 73152 185070 70670186
Blood stem cell transplant failure 94.43 18.04 31 73157 504 70854752
Infection reactivation 94.33 18.04 47 73141 2326 70852930
Polyomavirus viraemia 94.04 18.04 39 73149 1252 70854004
Graft versus host disease in eye 92.92 18.04 27 73161 285 70854971
Neoplasm recurrence 92.33 18.04 55 73133 3886 70851370
Staphylococcal sepsis 92.30 18.04 90 73098 13337 70841919
Urticaria 91.98 18.04 27 73161 163022 70692234
Muscle spasms 91.62 18.04 23 73165 154023 70701233
B-cell aplasia 90.60 18.04 24 73164 174 70855082
Chest pain 90.23 18.04 76 73112 251184 70604072
Stenotrophomonas infection 89.75 18.04 51 73137 3298 70851958
Autoimmune neutropenia 89.41 18.04 29 73159 453 70854803
Diarrhoea 89.26 18.04 461 72727 782880 70072376
Contusion 89.07 18.04 13 73175 128023 70727233
Aphasia 89.01 18.04 160 73028 43089 70812167
Discomfort 88.47 18.04 5 73183 105431 70749825
Dehydration 88.05 18.04 63 73125 226079 70629177
Inappropriate schedule of product administration 87.55 18.04 6 73182 107549 70747707
Chronic graft versus host disease in intestine 86.83 18.04 26 73162 307 70854949
Hepatic failure 85.69 18.04 186 73002 57439 70797817
Wound 84.99 18.04 4 73184 98728 70756528
Parainfluenzae virus infection 84.28 18.04 57 73131 5023 70850233
Acute respiratory distress syndrome 84.11 18.04 152 73036 41102 70814154
Bacterial infection 83.43 18.04 119 73069 26373 70828883
Aplasia 83.03 18.04 65 73123 7186 70848070
Myelosuppression 82.83 18.04 127 73061 30018 70825238
Toxic leukoencephalopathy 82.39 18.04 33 73155 967 70854289
Fungaemia 80.42 18.04 51 73137 4031 70851225
Capillary leak syndrome 80.29 18.04 48 73140 3414 70851842
Acute lymphocytic leukaemia 79.77 18.04 57 73131 5488 70849768
Disseminated intravascular coagulation 79.21 18.04 132 73056 33466 70821790
Clostridium difficile infection 77.84 18.04 142 73046 38674 70816582
Exposure during pregnancy 77.34 18.04 3 73185 87714 70767542
Skin toxicity 77.01 18.04 62 73126 7136 70848120
Pneumonia respiratory syncytial viral 76.13 18.04 35 73153 1446 70853810
Arthritis 75.47 18.04 7 73181 97973 70757283
Mobility decreased 75.13 18.04 9 73179 102990 70752266
Pulmonary haemorrhage 74.70 18.04 81 73107 13592 70841664
Infusion related reaction 74.34 18.04 57 73131 197477 70657779
Gastrooesophageal reflux disease 74.13 18.04 5 73183 90834 70764422
Weight decreased 73.37 18.04 130 73058 310358 70544898
Immune thrombocytopenia 72.72 18.04 87 73101 16237 70839019
Hospitalisation 72.21 18.04 3 73185 82565 70772691
Pneumocystis jirovecii pneumonia 72.01 18.04 119 73069 29963 70825293
Enterococcal bacteraemia 71.68 18.04 41 73147 2685 70852571
Musculoskeletal pain 70.80 18.04 6 73182 90321 70764935
Campylobacter infection 69.63 18.04 34 73154 1610 70853646
Hypoglycaemia 69.43 18.04 8 73180 94356 70760900
Palpitations 68.89 18.04 15 73173 110738 70744518
Serum ferritin increased 68.82 18.04 64 73124 8941 70846315
Syncope 68.74 18.04 43 73145 165666 70689590
Nephropathy toxic 68.63 18.04 90 73098 18424 70836832
Clostridium difficile colitis 68.46 18.04 114 73074 28882 70826374
Chronic lymphocytic leukaemia refractory 68.01 18.04 18 73170 130 70855126
Graft versus host disease in lung 67.35 18.04 27 73161 793 70854463
Abdominal pain upper 66.54 18.04 61 73127 193541 70661715
Candida sepsis 66.19 18.04 37 73151 2318 70852938
Cerebrovascular accident 65.60 18.04 33 73155 143437 70711819
Cerebral aspergillosis 64.59 18.04 33 73155 1723 70853533
Urinary tract infection 64.50 18.04 98 73090 248671 70606585
Disseminated toxoplasmosis 64.32 18.04 18 73170 164 70855092
Pseudomonal sepsis 64.19 18.04 50 73138 5487 70849769
Mucoepidermoid carcinoma of salivary gland 64.18 18.04 16 73172 88 70855168
Human herpesvirus 6 infection reactivation 63.99 18.04 21 73167 341 70854915
Transplant rejection 63.77 18.04 86 73102 18085 70837171
Lymphoproliferative disorder 63.69 18.04 49 73139 5280 70849976
Systemic candida 63.25 18.04 51 73137 5883 70849373
Staphylococcal bacteraemia 62.91 18.04 67 73121 11015 70844241
Injection site erythema 62.62 18.04 3 73185 72921 70782335
Upper respiratory fungal infection 62.29 18.04 20 73168 302 70854954
Hyperhidrosis 62.09 18.04 29 73159 131557 70723699
Pneumatosis intestinalis 61.48 18.04 50 73138 5837 70849419
Haemoglobin decreased 60.82 18.04 391 72797 204768 70650488
Neutropenic sepsis 60.48 18.04 99 73089 24731 70830525
Disease progression 60.33 18.04 320 72868 156352 70698904
Chimerism 60.04 18.04 19 73169 273 70854983
Klebsiella sepsis 59.87 18.04 37 73151 2794 70852462
Wrong technique in product usage process 58.43 18.04 3 73185 68695 70786561
Bronchitis 58.22 18.04 24 73164 117219 70738037
Loss of personal independence in daily activities 58.18 18.04 9 73179 84901 70770355
Pulmonary alveolar haemorrhage 57.65 18.04 62 73126 10307 70844949
Dyspepsia 57.61 18.04 11 73177 89066 70766190
Neoplasm progression 57.26 18.04 137 73051 45091 70810165
Sleep disorder 56.56 18.04 4 73184 69868 70785388
Escherichia sepsis 56.47 18.04 53 73135 7490 70847766
Out of specification test results 56.20 18.04 16 73172 156 70855100
Infection 56.03 18.04 391 72797 210394 70644862
Haemolysis 55.51 18.04 64 73124 11487 70843769
Geotrichum infection 55.37 18.04 25 73163 990 70854266
Toxicity to various agents 54.82 18.04 206 72982 381966 70473290
Blood cholesterol increased 54.39 18.04 3 73185 64601 70790655
Erythema 54.28 18.04 76 73112 199487 70655769
Lymphadenitis 53.95 18.04 40 73148 4077 70851179
Oedema peripheral 53.40 18.04 96 73092 227995 70627261
Mucosal disorder 53.33 18.04 36 73152 3162 70852094
Refractory cytopenia with multilineage dysplasia 53.05 18.04 17 73171 255 70855001
Gastroenteritis adenovirus 52.99 18.04 17 73171 256 70855000
Blood glucose increased 52.91 18.04 20 73168 102962 70752294
Adenoviral haemorrhagic cystitis 52.83 18.04 20 73168 502 70854754
Pleural effusion 52.26 18.04 273 72915 132591 70722665
Human polyomavirus infection 51.52 18.04 24 73164 1022 70854234
Escherichia bacteraemia 51.32 18.04 45 73143 5824 70849432
B-lymphocyte count abnormal 51.19 18.04 13 73175 78 70855178
Pneumonia adenoviral 51.10 18.04 19 73169 453 70854803
Suicidal ideation 50.95 18.04 6 73182 69590 70785666
Bradycardia 50.77 18.04 33 73155 124582 70730674
Transplant dysfunction 50.68 18.04 48 73140 6861 70848395
Chest discomfort 50.59 18.04 33 73155 124348 70730908
Wheezing 50.58 18.04 17 73171 94153 70761103
Blood follicle stimulating hormone increased 50.08 18.04 17 73171 308 70854948
Haematotoxicity 49.95 18.04 66 73122 13608 70841648
Injury 49.35 18.04 5 73183 65240 70790016
Blister 49.23 18.04 21 73167 100505 70754751
Klebsiella infection 49.18 18.04 67 73121 14225 70841031
Hepatic enzyme increased 48.75 18.04 54 73134 156936 70698320
Migraine 48.71 18.04 8 73180 72230 70783026
Bone marrow transplant 48.69 18.04 25 73163 1319 70853937
Chloroma 48.59 18.04 21 73167 748 70854508
Rotavirus infection 48.05 18.04 20 73168 648 70854608
Hyperkalaemia 48.00 18.04 25 73163 106566 70748690
Hepatitis B 47.74 18.04 50 73138 8064 70847192
Myalgia 47.62 18.04 62 73126 167830 70687426
Hypoaesthesia 47.61 18.04 53 73135 153686 70701570
Chronic obstructive pulmonary disease 47.31 18.04 11 73177 77630 70777626
Gastroenteritis norovirus 47.24 18.04 32 73156 2827 70852429
Intentional product misuse 47.08 18.04 12 73176 79583 70775673
Loss of consciousness 46.79 18.04 55 73133 155661 70699595
Chronic lymphocytic leukaemia transformation 46.75 18.04 15 73173 226 70855030
5q minus syndrome 46.72 18.04 16 73172 298 70854958
Hepatitis B reactivation 46.71 18.04 41 73147 5314 70849942
Alpha haemolytic streptococcal infection 46.61 18.04 28 73160 2009 70853247
Viral sinusitis 46.56 18.04 15 73173 229 70855027
Cough 46.25 18.04 176 73012 325201 70530055
Osteoarthritis 46.19 18.04 10 73178 74137 70781119
Alternaria infection 46.16 18.04 19 73169 598 70854658
Autoimmune lymphoproliferative syndrome 46.03 18.04 14 73174 175 70855081
Myeloid leukaemia 45.49 18.04 19 73169 621 70854635
Pathogen resistance 45.31 18.04 62 73126 13217 70842039
Meningitis cryptococcal 45.11 18.04 33 73155 3295 70851961
Leukaemic infiltration 45.10 18.04 13 73175 133 70855123
Blood fibrinogen decreased 44.69 18.04 26 73162 1758 70853498
Influenza like illness 44.58 18.04 7 73181 65324 70789932
Blood pressure systolic increased 44.33 18.04 4 73184 57255 70798001
Abdominal pain 44.27 18.04 192 72996 341935 70513321
Cryptosporidiosis infection 43.82 18.04 19 73169 682 70854574
Mycobacterium kansasii infection 43.82 18.04 16 73172 362 70854894
Rhabdomyolysis 43.80 18.04 22 73166 95738 70759518
Angioedema 43.55 18.04 8 73180 66602 70788654
Microangiopathy 43.41 18.04 25 73163 1658 70853598
Respiratory tract infection fungal 43.37 18.04 22 73166 1131 70854125
Herpes virus infection 43.15 18.04 43 73145 6541 70848715
Hepatic vein occlusion 42.85 18.04 13 73175 161 70855095
Rubulavirus test positive 42.70 18.04 9 73179 19 70855237
Paraparesis 42.57 18.04 33 73155 3596 70851660
Obliterative bronchiolitis 42.56 18.04 30 73158 2827 70852429
Hyponatraemia 42.50 18.04 62 73126 160025 70695231
Cytomegalovirus colitis 42.26 18.04 35 73153 4191 70851065
Scedosporium infection 42.04 18.04 23 73165 1381 70853875
Myelitis 41.28 18.04 27 73161 2250 70853006
Heart rate abnormal 41.02 18.04 39 73149 5600 70849656
Post transplant distal limb syndrome 40.86 18.04 17 73171 550 70854706
Heart rate increased 40.72 18.04 30 73158 106118 70749138
Decreased appetite 40.68 18.04 169 73019 304611 70550645
Growth retardation 40.65 18.04 24 73164 1668 70853588
Bronchiolitis obliterans syndrome 40.43 18.04 14 73174 270 70854986
Splenomegaly 40.35 18.04 71 73117 18799 70836457
Candida infection 40.00 18.04 101 73087 34372 70820884
Meningomyelitis herpes 39.96 18.04 10 73178 56 70855200
Cytomegalovirus hepatitis 39.69 18.04 18 73170 720 70854536
Coronavirus infection 39.44 18.04 40 73148 6212 70849044
Unevaluable event 39.35 18.04 4 73184 52059 70803197
Refractory anaemia with an excess of blasts 39.32 18.04 19 73169 879 70854377
Blood creatine phosphokinase increased 38.70 18.04 8 73180 61255 70794001
Cytokine storm 38.67 18.04 19 73169 912 70854344
Disseminated mucormycosis 38.55 18.04 17 73171 636 70854620
Enterococcal sepsis 38.44 18.04 27 73161 2530 70852726
Death 38.43 18.04 339 72849 509722 70345534
Fungal sepsis 37.91 18.04 23 73165 1680 70853576
Burning sensation 37.62 18.04 5 73183 52865 70802391
Nephrolithiasis 37.48 18.04 3 73185 47320 70807936
Flushing 37.40 18.04 19 73169 82153 70773103
Injection site reaction 37.24 18.04 4 73184 49848 70805408
Hyperbilirubinaemia 37.20 18.04 76 73112 22492 70832764
Hot flush 36.98 18.04 4 73184 49580 70805676
Citrobacter infection 36.83 18.04 18 73170 854 70854402
Mucosal toxicity 36.76 18.04 16 73172 580 70854676
Renal failure 36.59 18.04 326 72862 188744 70666512
Lung consolidation 36.56 18.04 44 73144 8262 70846994
Balance disorder 36.52 18.04 24 73164 90104 70765152
Rash pruritic 36.30 18.04 10 73178 62981 70792275
International normalised ratio increased 36.24 18.04 19 73169 80707 70774549
Device related infection 36 18.04 93 73095 32092 70823164
Myelopathy 35.98 18.04 32 73156 4219 70851037
Neck pain 35.85 18.04 12 73176 66645 70788611
Complications of bone marrow transplant 35.76 18.04 16 73172 620 70854636
Neurological symptom 35.23 18.04 41 73147 7432 70847824
Paraesthesia 35.18 18.04 60 73128 145477 70709779
Rectal haemorrhage 35.15 18.04 12 73176 65819 70789437
Apoptosis 35.00 18.04 13 73175 309 70854947
Post-depletion B-cell recovery 34.94 18.04 7 73181 10 70855246
Stenotrophomonas sepsis 34.83 18.04 11 73177 157 70855099
Gait inability 34.70 18.04 4 73184 47171 70808085
General physical health deterioration 34.61 18.04 126 73062 235905 70619351
Acute myocardial infarction 34.47 18.04 16 73172 72871 70782385
Type 2 diabetes mellitus 34.34 18.04 3 73185 44077 70811179
Sedation 34.28 18.04 4 73184 46727 70808529
Coronary artery disease 34.26 18.04 11 73177 62725 70792531
Treatment noncompliance 34.13 18.04 4 73184 46570 70808686
Delayed engraftment 34.06 18.04 12 73176 244 70855012
Oxygen saturation decreased 34.04 18.04 42 73146 116387 70738869
Gene mutation 33.99 18.04 24 73164 2267 70852989
Somnolence 33.69 18.04 112 73076 215494 70639762
Cerebral fungal infection 33.52 18.04 13 73175 349 70854907
Aggression 33.49 18.04 5 73183 48441 70806815
Leukoerythroblastosis 33.35 18.04 12 73176 260 70854996
Escherichia infection 33.06 18.04 60 73128 16271 70838985
Neurological decompensation 32.91 18.04 32 73156 4724 70850532
Dysphonia 32.79 18.04 6 73182 50094 70805162
Dysphagia 32.68 18.04 41 73147 112793 70742463
Multisystem inflammatory syndrome in children 32.56 18.04 8 73180 41 70855215
NPM1 gene mutation 32.52 18.04 10 73178 130 70855126
Transformation to acute myeloid leukaemia 32.50 18.04 17 73171 932 70854324
Vertigo 32.45 18.04 12 73176 62631 70792625
Oropharyngeal pain 32.30 18.04 31 73157 96279 70758977
B-cell lymphoma 32.27 18.04 36 73152 6233 70849023
Chronic myeloid leukaemia recurrent 32.05 18.04 12 73176 292 70854964
Neutropenic infection 32.04 18.04 22 73166 1987 70853269
Glomerulosclerosis 32.04 18.04 17 73171 960 70854296
Pulmonary embolism 31.83 18.04 71 73117 155796 70699460
Brain sarcoma 31.50 18.04 8 73180 48 70855208
Impaired healing 31.24 18.04 19 73169 74355 70780901
Metastatic malignant melanoma 31.22 18.04 26 73162 3138 70852118
Cytomegalovirus gastroenteritis 31.18 18.04 13 73175 423 70854833
Enterovirus infection 30.75 18.04 20 73168 1651 70853605
Refractory cytopenia with unilineage dysplasia 30.48 18.04 16 73172 884 70854372
Lymphocytosis 30.41 18.04 28 73160 3862 70851394
Recurrent cancer 30.39 18.04 23 73165 2418 70852838
Diffuse large B-cell lymphoma refractory 30.10 18.04 18 73170 1281 70853975
Enterocolitis viral 30.01 18.04 12 73176 350 70854906
Leukaemic infiltration extramedullary 29.94 18.04 10 73178 172 70855084
Achromobacter infection 29.41 18.04 9 73179 115 70855141
Retinal haemorrhage 29.38 18.04 38 73150 7672 70847584
Reticulocytosis 29.37 18.04 13 73175 491 70854765
Eccrine squamous syringometaplasia 29.33 18.04 7 73181 31 70855225
Acute erythroid leukaemia 29.32 18.04 11 73177 269 70854987
Medication error 29.32 18.04 11 73177 56901 70798355
Aplasia pure red cell 29.13 18.04 37 73151 7337 70847919
Malignant transformation 29.13 18.04 17 73171 1156 70854100
Blindness 29.01 18.04 70 73118 23157 70832099
Skin ulcer 28.97 18.04 7 73181 48138 70807118
Central nervous system leukaemia 28.88 18.04 12 73176 387 70854869
Roseolovirus test positive 28.77 18.04 10 73178 195 70855061
Iron overload 28.51 18.04 19 73169 1634 70853622
Gastrointestinal toxicity 28.30 18.04 34 73154 6371 70848885
Polymyositis 28.25 18.04 24 73164 2977 70852279
Cardiac disorder 28.16 18.04 13 73175 59402 70795854
Graft complication 28.15 18.04 14 73174 690 70854566
Dysgraphia 28.11 18.04 26 73162 3606 70851650
Retinitis viral 28.08 18.04 9 73179 135 70855121
Chronic myelomonocytic leukaemia 27.80 18.04 15 73173 876 70854380
Refractoriness to platelet transfusion 27.72 18.04 9 73179 141 70855115
Anaphylactic reaction 27.72 18.04 22 73166 74952 70780304
Gastrointestinal infection 27.51 18.04 41 73147 9450 70845806
Nasal congestion 27.27 18.04 17 73171 65655 70789601
Organising pneumonia 27.12 18.04 42 73146 10008 70845248
Transient ischaemic attack 27.03 18.04 7 73181 45937 70809319
Retinal infiltrates 27.02 18.04 7 73181 46 70855210
Human metapneumovirus test positive 26.99 18.04 9 73179 154 70855102
Dry skin 26.88 18.04 12 73176 55919 70799337
Sinusitis fungal 26.75 18.04 20 73168 2065 70853191
Femur fracture 26.73 18.04 3 73185 36129 70819127
Electrocardiogram QT prolonged 26.72 18.04 28 73160 83489 70771767
Swelling face 26.72 18.04 16 73172 63148 70792108
Poikiloderma 26.50 18.04 11 73177 354 70854902
Pulmonary mucormycosis 26.48 18.04 15 73173 964 70854292
Pericardial effusion 26.44 18.04 99 73089 41677 70813579
Disease recurrence 26.25 18.04 92 73096 37511 70817745
Meningitis tuberculous 26.22 18.04 16 73172 1181 70854075
Disseminated Bacillus Calmette-Guerin infection 26.16 18.04 10 73178 258 70854998
Pneumoretroperitoneum 26.11 18.04 9 73179 171 70855085
Lung infiltration 25.76 18.04 64 73124 21560 70833696
Immunodeficiency common variable 25.73 18.04 10 73178 270 70854986
Bordetella infection 25.67 18.04 8 73180 109 70855147
Anti-platelet antibody positive 25.63 18.04 10 73178 273 70854983
Dysplasia 25.62 18.04 16 73172 1231 70854025
Therapy partial responder 25.47 18.04 46 73142 12428 70842828
Lower respiratory tract infection 25.37 18.04 48 73140 111865 70743391
Pericarditis 25.35 18.04 30 73158 84675 70770581
B-cell lymphoma recurrent 25.15 18.04 14 73174 870 70854386
Pneumonia pseudomonal 25.09 18.04 29 73159 5217 70850039
Autoimmune pancytopenia 24.93 18.04 9 73179 197 70855059
Pulmonary veno-occlusive disease 24.92 18.04 17 73171 1519 70853737
Head injury 24.85 18.04 3 73185 34138 70821118
Evans syndrome 24.66 18.04 11 73177 423 70854833
Primary amyloidosis 24.63 18.04 9 73179 204 70855052
Retinopathy haemorrhagic 24.61 18.04 7 73181 68 70855188
Blindness cortical 24.58 18.04 14 73174 909 70854347
Bacille Calmette-Guerin scar reactivation 24.55 18.04 6 73182 30 70855226
Dry mouth 24.42 18.04 22 73166 70435 70784821
Hepatomegaly 24.34 18.04 55 73133 17437 70837819
Dysbiosis 24.29 18.04 14 73174 930 70854326
Parainfluenzae viral bronchitis 24.25 18.04 5 73183 9 70855247
Respiratory distress 24.08 18.04 116 73072 54534 70800722
Gastric disorder 24.07 18.04 3 73185 33319 70821937
Neutropenic colitis 24.01 18.04 28 73160 5086 70850170
Diffuse alveolar damage 23.97 18.04 23 73165 3340 70851916
Pneumonia bacterial 23.91 18.04 53 73135 16588 70838668
Clonal evolution 23.88 18.04 9 73179 223 70855033
Squamous cell carcinoma 23.86 18.04 49 73139 14555 70840701
Angina pectoris 23.86 18.04 10 73178 48373 70806883
Enterobacter infection 23.85 18.04 25 73163 4035 70851221
Tumour flare 23.79 18.04 14 73174 967 70854289
Polyomavirus-associated nephropathy 23.71 18.04 28 73160 5155 70850101
Disseminated tuberculosis 23.65 18.04 25 73163 4075 70851181
Enterobacter bacteraemia 23.51 18.04 12 73176 625 70854631
Memory impairment 23.50 18.04 37 73151 92604 70762652
Brain oedema 23.49 18.04 65 73123 23353 70831903
Accidental overdose 23.43 18.04 4 73184 35117 70820139
Neutrophil Pelger-Huet anomaly present 23.41 18.04 10 73178 346 70854910
Lymphoma transformation 23.33 18.04 9 73179 238 70855018
Dysgeusia 23.20 18.04 11 73177 49491 70805765
Premature ageing 23.12 18.04 7 73181 86 70855170
Hyperfibrinogenaemia 23.12 18.04 7 73181 86 70855170
Immune reconstitution inflammatory syndrome 22.91 18.04 45 73143 12945 70842311
Cerebellar tumour 22.91 18.04 7 73181 89 70855167
CNS ventriculitis 22.88 18.04 10 73178 366 70854890
Abdominal distension 22.77 18.04 46 73142 104623 70750633
Arrhythmia 22.68 18.04 15 73173 56128 70799128
Red blood cell sedimentation rate increased 22.52 18.04 6 73182 38636 70816620
Cord blood transplant therapy 22.47 18.04 6 73182 45 70855211
Kidney fibrosis 22.45 18.04 22 73166 3278 70851978
Lip swelling 22.45 18.04 4 73184 34050 70821206
Bacterial translocation 22.45 18.04 11 73177 525 70854731
Nodular melanoma 22.42 18.04 8 73180 169 70855087
Haptoglobin decreased 22.38 18.04 15 73173 1302 70853954
Metastases to bone marrow 22.37 18.04 12 73176 693 70854563
Metastases to diaphragm 22.36 18.04 6 73182 46 70855210
Spirochaetal infection 22.23 18.04 5 73183 16 70855240
Colitis herpes 22.23 18.04 5 73183 16 70855240
Herpes zoster meningoencephalitis 22.21 18.04 12 73176 703 70854553
Hydrocephalus 22.12 18.04 34 73154 8051 70847205
Cardio-respiratory arrest 22.11 18.04 44 73144 100633 70754623
Gastroenteritis rotavirus 22.05 18.04 10 73178 400 70854856
Orthostatic hypotension 22.04 18.04 13 73175 51730 70803526
Adult T-cell lymphoma/leukaemia recurrent 22.00 18.04 5 73183 17 70855239
Breast cancer 21.99 18.04 4 73184 33545 70821711
Hepatosplenomegaly 21.69 18.04 28 73160 5642 70849614
Deep vein thrombosis 21.53 18.04 52 73136 110990 70744266
Neuroblastoma recurrent 21.48 18.04 7 73181 111 70855145
Adenomatous polyposis coli 21.39 18.04 8 73180 194 70855062
Acute myeloid leukaemia refractory 21.37 18.04 7 73181 113 70855143
Hepatitis viral 21.29 18.04 13 73175 961 70854295
Urinary retention 21.26 18.04 14 73174 52506 70802750
Viral myocarditis 21.21 18.04 10 73178 438 70854818
Dyspnoea exertional 21.18 18.04 30 73158 78400 70776856
Diabetes mellitus 20.89 18.04 26 73162 71798 70783458
Muscle twitching 20.86 18.04 56 73132 19771 70835485
Human herpes virus 6 serology positive 20.83 18.04 8 73180 209 70855047
Organic brain syndrome 20.83 18.04 10 73178 456 70854800
Arthritis fungal 20.82 18.04 7 73181 123 70855133
Folliculitis 20.67 18.04 9 73179 42561 70812695
Sinusitis 20.62 18.04 97 73091 169098 70686158
Respirovirus test positive 20.61 18.04 7 73181 127 70855129
Cardiomyopathy 20.59 18.04 67 73121 26306 70828950
Periorbital cellulitis 20.55 18.04 12 73176 817 70854439
Klebsiella bacteraemia 20.54 18.04 19 73169 2635 70852621
Epstein-Barr virus test positive 20.47 18.04 13 73175 1030 70854226
Precursor B-lymphoblastic lymphoma recurrent 20.45 18.04 5 73183 25 70855231
Hepatic necrosis 20.41 18.04 34 73154 8612 70846644
Chromosome analysis abnormal 20.38 18.04 8 73180 222 70855034
Gastroenteritis clostridial 20.38 18.04 12 73176 830 70854426
Meningitis enteroviral 20.34 18.04 6 73182 67 70855189
Haemolytic anaemia 20.32 18.04 50 73138 16744 70838512
Non-Hodgkin's lymphoma recurrent 20.29 18.04 5 73183 26 70855230
Primary mediastinal large B-cell lymphoma 20.10 18.04 6 73182 70 70855186
Organ failure 20.08 18.04 22 73166 3734 70851522
Urinary tract infection viral 19.95 18.04 6 73182 72 70855184
Paraneoplastic pemphigus 19.93 18.04 7 73181 141 70855115
Embryonal rhabdomyosarcoma 19.87 18.04 6 73182 73 70855183
Growth failure 19.83 18.04 8 73180 239 70855017
Central nervous system enteroviral infection 19.80 18.04 6 73182 74 70855182
Haematemesis 19.76 18.04 13 73175 48784 70806472
Leukaemia 19.72 18.04 26 73162 5349 70849907
Parvovirus B19 infection 19.71 18.04 14 73174 1335 70853921
Gastroenteritis sapovirus 19.70 18.04 7 73181 146 70855110
Toxic erythema of chemotherapy 19.67 18.04 8 73180 244 70855012
Transplantation associated food allergy 19.37 18.04 6 73182 80 70855176
Blood bilirubin unconjugated increased 19.33 18.04 12 73176 913 70854343
Rhinorrhoea 19.33 18.04 24 73164 66347 70788909
Immunosuppression 19.30 18.04 39 73149 11453 70843803
Cataract subcapsular 19.26 18.04 12 73176 919 70854337
Cardiac arrest 19.26 18.04 92 73096 159742 70695514
Cardiotoxicity 19.10 18.04 38 73150 11032 70844224
CSF protein increased 19.08 18.04 13 73175 1159 70854097
Rhodococcus infection 18.97 18.04 8 73180 268 70854988
Therapy non-responder 18.85 18.04 140 73048 76775 70778481
Herpes simplex viraemia 18.83 18.04 8 73180 273 70854983
Vision blurred 18.79 18.04 44 73144 94940 70760316
Pneumonia viral 18.77 18.04 32 73156 8260 70846996
Ear pain 18.73 18.04 3 73185 27596 70827660
Hemiparesis 18.62 18.04 73 73115 31396 70823860
Serum sickness 18.61 18.04 20 73168 3321 70851935
Adrenal haemorrhage 18.52 18.04 10 73178 585 70854671
Bladder hypertrophy 18.52 18.04 10 73178 585 70854671
Limbic encephalitis 18.49 18.04 11 73177 775 70854481
Lactic acidosis 18.44 18.04 24 73164 65000 70790256
Pneumonia klebsiella 18.43 18.04 23 73165 4481 70850775
Stenotrophomonas bacteraemia 18.33 18.04 5 73183 41 70855215
Chronic lymphocytic leukaemia stage 2 18.23 18.04 4 73184 11 70855245
Gastritis fungal 18.12 18.04 7 73181 186 70855070
Optic atrophy 18.08 18.04 15 73173 1800 70853456

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
ATC L01BB05 ANTINEOPLASTIC AND IMMUNOMODULATING AGENTS
ANTINEOPLASTIC AGENTS
ANTIMETABOLITES
Purine analogues
FDA MoA N0000000233 Nucleic Acid Synthesis Inhibitors
FDA EPC N0000175595 Nucleoside Metabolic Inhibitor
MeSH PA D000970 Antineoplastic Agents
MeSH PA D000963 Antimetabolites
MeSH PA D000964 Antimetabolites, Antineoplastic
MeSH PA D007155 Immunologic Factors
MeSH PA D007166 Immunosuppressive Agents
MeSH PA D009676 Noxae
CHEBI has role CHEBI:22587 antiviral agents
CHEBI has role CHEBI:35221 antimetabolite
CHEBI has role CHEBI:35610 antineoplastic agents
CHEBI has role CHEBI:35705 immunosuppressive agents
CHEBI has role CHEBI:50266 Prodrugs
CHEBI has role CHEBI:59517 DNA synthesis inhibitors

Drug Use | Suggest Off label Use Form| |View source of the data|

DiseaseRelationSNOMED_IDDOID
Acute myeloid leukemia, disease indication 91861009
Chronic lymphoid leukemia, disease indication 92814006
Low-grade B cell non-Hodgkin lymphoma indication 118601006
Mantle cell lymphoma indication 443487006
Acute myeloid leukemia, disease off-label use 91861009
Waldenström macroglobulinemia off-label use 190818004 DOID:0050747
Follicular non-Hodgkin's lymphoma off-label use 308121000
Mycosis contraindication 3218000 DOID:1564
Herpes zoster contraindication 4740000 DOID:8536
Acquired hemolytic anemia contraindication 4854004
Acquired factor VIII deficiency disease contraindication 14230004
Progressive multifocal leukoencephalopathy contraindication 22255007 DOID:643
Feeling agitated contraindication 24199005
Idiopathic thrombocytopenic purpura contraindication 32273002 DOID:8924
Extrinsic allergic alveolitis contraindication 37471005 DOID:841
Conduction disorder of the heart contraindication 44808001
Acute nephropathy contraindication 58574008
Acute infectious disease contraindication 63171007
Interstitial pneumonia contraindication 64667001
Optic neuritis contraindication 66760008 DOID:1210
Evans syndrome contraindication 75331009 DOID:8931
Disorder of optic nerve contraindication 77157004 DOID:1891
Bacterial infectious disease contraindication 87628006
Pancytopenia contraindication 127034005 DOID:12450
Autoimmune thrombocytopenia contraindication 128091003
Seizure disorder contraindication 128613002
Liver function tests abnormal contraindication 166603001
Decompensated cardiac failure contraindication 195111005
Impaired renal function disorder contraindication 197663003
Edema contraindication 267038008
Anemia contraindication 271737000 DOID:2355
Uric acid renal calculus contraindication 274401005
Pregnancy, function contraindication 289908002
Neutropenic disorder contraindication 303011007 DOID:1227
Bone marrow depression contraindication 307762000
Coma contraindication 371632003
Impaired cognition contraindication 386806002
Visual impairment contraindication 397540003
Autoimmune hemolytic anemia contraindication 413603009 DOID:718
Breastfeeding (mother) contraindication 413712001
CNS Toxicity contraindication
Chemotherapy-Induced Hyperuricemia contraindication




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 1.31 acidic
pKa2 6.36 acidic
pKa3 12.46 acidic
pKa4 13.04 acidic
pKa5 2.93 Basic
pKa6 2.33 Basic

Orange Book patent data (new drug applications)

Formulation strengthTrade nameApplicantApplication numberApproval dateTypeDose formRoutePatent numberPatent expiration datePatent use
10MG OFORTA SANOFI AVENTIS US N022273 Dec. 18, 2008 DISCN TABLET ORAL 7148207 Dec. 20, 2022 TREATMENT OF PATIENTS WITH B-CELL CHRONIC LYMPHOCYTIC LEUKEMIA (CLL)

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])		Mechanism
action		Bioact sourceMoA source
DNA polymerase alpha catalytic subunit Enzyme INHIBITOR WOMBAT-PK DRUG LABEL
Ribonucleoside-diphosphate reductase subunit M2 Enzyme INHIBITOR IC50 6 IUPHAR
Carbonic anhydrase 5A, mitochondrial Enzyme Ki 6.88 CHEMBL
Ribonucleoside-diphosphate reductase large subunit Enzyme INHIBITOR IC50 6 IUPHAR
Adenosine receptor A2a GPCR Ki 7.55 CHEMBL
Adenosine receptor A3 GPCR Ki 4.98 CHEMBL
Adenosine receptor A1 GPCR Ki 8.23 CHEMBL

External reference:

IDSource
4020528 VUID
N0000148244 NUI
D01907 KEGG_DRUG
4020177 VANDF
4020528 VANDF
C0060483 UMLSCUI
CHEBI:63599 CHEBI
CHEMBL1096882 ChEMBL_ID
C042382 MESH_SUPPLEMENTAL_RECORD_UI
C024352 MESH_SUPPLEMENTAL_RECORD_UI
4802 IUPHAR_LIGAND_ID
1X9VK9O1SC UNII
30751 PUBCHEM_CID
DB01073 DRUGBANK_ID
24698 RXNORM
110964 MMSL
1862 MMSL
4734 MMSL
d01346 MMSL
003618 NDDF
004817 NDDF
108763009 SNOMEDCT_US
108765002 SNOMEDCT_US
386907005 SNOMEDCT_US
C0059985 UMLSCUI
5214 INN_ID
21679-14-1 SECONDARY_CAS_RN
657237 PUBCHEM_CID
P2K93U8740 UNII

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
FLUDARABINE PHOSPHATE HUMAN PRESCRIPTION DRUG LABEL 1 16729-131 INJECTION 25 mg INTRAVENOUS Unapproved drug for use in drug shortage 2 sections
fludarabine phosphate HUMAN PRESCRIPTION DRUG LABEL 1 24201-237 INJECTION, POWDER, LYOPHILIZED, FOR SOLUTION 25 mg INTRAVENOUS ANDA 24 sections
Fludarabine Phosphate HUMAN PRESCRIPTION DRUG LABEL 1 25021-242 INJECTION, SOLUTION 25 mg INTRAVENOUS ANDA 28 sections
Fludarabine phosphate HUMAN PRESCRIPTION DRUG LABEL 1 45963-609 INJECTION, POWDER, LYOPHILIZED, FOR SOLUTION 50 mg INTRAVENOUS ANDA 21 sections
Fludarabine phosphate HUMAN PRESCRIPTION DRUG LABEL 1 45963-621 INJECTION, SOLUTION 25 mg INTRAVENOUS ANDA 19 sections
Fludarabine Phosphate HUMAN PRESCRIPTION DRUG LABEL 1 59923-604 INJECTION 25 mg INTRAVENOUS ANDA 28 sections
Fludarabine HUMAN PRESCRIPTION DRUG LABEL 1 63323-192 INJECTION, SOLUTION 25 mg INTRAVENOUS ANDA 14 sections