Scroll

doxapram 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definition	Drug id	CAS RN
	953	309-29-5

Description:

Molecule	Description
Molfile Inchi Smiles Synonyms: doxapram hydrochloride hydrate dopram doxapram doxapram hydrochloride doxapram HCl	A central respiratory stimulant with a brief duration of action. (From Martindale, The Extra Pharmocopoeia, 30th ed, p1225) Molecular weight: 378.52 Formula: C24H30N2O2 CLOGP: 3.04 LIPINSKI: 0 HAC: 4 HDO: 0 TPSA: 32.78 ALOGS: -4.04 ROTB: 6 Status: OFP Legend: OFP - off patent OFM - off market ONP - on patent

Molecule

Description

Molfile Inchi Smiles

Synonyms:

doxapram hydrochloride hydrate
dopram
doxapram
doxapram hydrochloride
doxapram HCl

A central respiratory stimulant with a brief duration of action. (From Martindale, The Extra Pharmocopoeia, 30th ed, p1225)

Molecular weight: 378.52
Formula: C24H30N2O2
CLOGP: 3.04
LIPINSKI: 0
HAC: 4
HDO: 0
TPSA: 32.78
ALOGS: -4.04
ROTB: 6

Status: OFP

Legend:
OFP - off patent
OFM - off market
ONP - on patent

Drug dosage:

Dose	Unit	Route
0.40	g	P

ADMET properties:

Show entries

Search:

Property	Value	Reference
BA (Bioavailability)	64 %	Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H
CL (Clearance)	5.30 mL/min/kg	Lombardo F, Berellini G, Obach RS
t_half (Half-life)	4.10 hours	Lombardo F, Berellini G, Obach RS
S (Water solubility)	25 mg/mL	Bocci G, Oprea TI, Benet LZ
MRTD (Maximum Recommended Therapeutic Daily Dose)	10.57 µM/kg/day	Contrera JF, Matthews EJ, Kruhlak NL, Benz RD
Vd (Volume of distribution)	1.20 L/kg	Lombardo F, Berellini G, Obach RS
BDDCS (Biopharmaceutical Drug Disposition Classification System)	1	Bocci G, Oprea TI, Benet LZ

Showing 1 to 7 of 7 entries

Previous1Next

Approvals:

Date	Agency	Company	Orphan
June 23, 1965	FDA	HIKMA MAPLE

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

None

FDA Adverse Event Reporting System (Geriatric)

None

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

Show entries

Search:

Source	Code	Description
ATC	R07AB01	RESPIRATORY SYSTEM OTHER RESPIRATORY SYSTEM PRODUCTS OTHER RESPIRATORY SYSTEM PRODUCTS Respiratory stimulants
CHEBI has role	CHEBI:35337	analeptic
FDA EPC	N0000175716	Respiratory Stimulant
FDA PE	N0000009393	Increased Medullary Respiratory Drive
MeSH PA	D002491	Central Nervous System Agents
MeSH PA	D000697	Central Nervous System Stimulants
MeSH PA	D019141	Respiratory System Agents

Showing 1 to 7 of 7 entries

Previous1Next

Drug Use | Suggest Off label Use Form| |View source of the data|

Show entries

Search:

Disease	Relation	SNOMED_ID	DOID
Decreased respiratory function	indication	80954004
Post-Anesthesia Respiratory Depression	indication
Apnea in the newborn	off-label use	13094009
Cerebral edema	contraindication	2032001
Chronic obstructive lung disease	contraindication	13645005	DOID:3083
Hyperthyroidism	contraindication	34486009	DOID:7998
Pneumothorax	contraindication	36118008
Artificial respiration	contraindication	40617009
Paralysis	contraindication	44695005
Conduction disorder of the heart	contraindication	44808001

Showing 1 to 10 of 28 entries

Previous1 2 3Next

🐶 Veterinary Drug Use

Show entries

Search:

Species	Use	Relation
Cats	Stimulation of respiration during and after general anesthesia	Indication
Cats	Acceleration of awakening and return of reflexes after anesthesia	Indication
Cats	To initiate respiration following dystocia or caesarean section	Indication
Cats	Stimulation of respiration following dystocia or caesarean section	Indication
Dogs	Stimulation of respiration during and after general anesthesia	Indication
Dogs	Acceleration of awakening and return of reflexes after anesthesia	Indication
Dogs	To initiate respiration following dystocia or caesarean section	Indication
Dogs	Stimulation of respiration following dystocia or caesarean section	Indication
Horses	Stimulation of respiration during and after general anesthesia	Indication
Horses	Acceleration of awakening and return of reflexes after anesthesia	Indication

Showing 1 to 10 of 10 entries

Previous1Next

🐶 Veterinary products

Product	Applicant	Ingredients
Dopram-V Injectable	Boehringer lngelheim Animal Health USA Inc.	1

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation level	Dissociation constant	Type (acidic/basic)
pKa1	7.03	Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

Show entries

Search:

Target	Class	Pharos	UniProt	Action	Type	Activity value (-log[M])	Bioact source	MoA source
Potassium channel subfamily K member 3	Ion channel	O14649	KCNK3_HUMAN	BLOCKER			CHEMBL	CHEMBL
Potassium channel subfamily K member 9	Ion channel	Q9NPC2	KCNK9_HUMAN	BLOCKER			CHEMBL	CHEMBL
Cytochrome P450 2D6	Enzyme	P10635	CP2D6_HUMAN		IC50	7	DRUG MATRIX
Potassium channel subfamily K member 3	Ion channel		KCNK3_RAT		IC50	6.39	CHEMBL
Potassium channel subfamily K member 9	Ion channel		KCNK9_RAT		IC50	4.80	CHEMBL

Showing 1 to 5 of 5 entries

Previous1Next

External reference:

Show entries

Search:

ID	Source
001383	NDDF
004577	NDDF
1462	INN_ID
202987	RXNORM
28235004	SNOMEDCT_US
3156	PUBCHEM_CID
3192	MMSL
332	MMSL
373339005	SNOMEDCT_US
4018416	VANDF

Showing 1 to 10 of 27 entries

Previous1 2 3Next

Pharmaceutical products:

Show entries

Search:

Product	Category	Ingredients	NDC	Form	Quantity	Route	Marketing	Label
Dopram	HUMAN PRESCRIPTION DRUG LABEL	1	0641-6018	INJECTION	20 mg	INTRAVENOUS	NDA	20 sections
DOXAPRAM HYDROCHLORIDE	HUMAN PRESCRIPTION DRUG LABEL	1	51662-1404	INJECTION	20 mg	INTRAVENOUS	NDA	12 sections

Showing 1 to 2 of 2 entries

Previous1Next