pentetrazol 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | PK/Tox | Related Drugs | BioActivity |

Stem definitionDrug idCAS RN
3428 54-95-5

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • pentylenetetrazole
  • 1,5-Pentamethylenetetrazole
  • cardiazole
  • pentetrazol
  • pentamethazol
  • pentazol
  • leptazol
A pharmaceutical agent that displays activity as a central nervous system and respiratory stimulant. It is considered a non-competitive GAMMA-AMINOBUTYRIC ACID antagonist. Pentylenetetrazole has been used experimentally to study seizure phenomenon and to identify pharmaceuticals that may control seizure susceptibility.
  • Molecular weight: 138.17
  • Formula: C6H10N4
  • CLOGP: 1.34
  • LIPINSKI: 0
  • HAC: 4
  • HDO: 0
  • TPSA: 43.60
  • ALOGS: -1.49
  • ROTB: 0

Drug dosage:

DoseUnitRoute
0.10 g O

ADMET properties:

None

Predicted pharmacokinetic/toxicological properties (PK-AZ):

PropertyDescriptionValueUnitConfidenceSimilarity
kinase-safety-class ACVR2B,AXL,BRAF,EIF2AK3,ERBB2,GRK2,PDK1,PDK4,PRKDC 9
pfas-class PFAS structural alert (1 = True, 0 = False) 0

Approvals:

None

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

None

FDA Adverse Event Reporting System (Geriatric)

None

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
ATC R07AB03 RESPIRATORY SYSTEM
OTHER RESPIRATORY SYSTEM PRODUCTS
OTHER RESPIRATORY SYSTEM PRODUCTS
Respiratory stimulants
ATC R07AB53 RESPIRATORY SYSTEM
OTHER RESPIRATORY SYSTEM PRODUCTS
OTHER RESPIRATORY SYSTEM PRODUCTS
Respiratory stimulants
MeSH PA D000697 Central Nervous System Stimulants
MeSH PA D003292 Convulsants
MeSH PA D018377 Neurotransmitter Agents
MeSH PA D018682 GABA Agents
MeSH PA D018756 GABA Antagonists

Related Drugs by ATC class:

R07AB Respiratory stimulants 8 drugs
almitrinebemegridedimeflinedoxaprametamivanmepixanoxnikethamideprethcamide

Drug Use | Suggest Off label Use Form| |View source of the data|

None




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

None

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

None

External reference:

IDSource
4019159 VUID
N0000147404 NUI
D07409 KEGG_DRUG
4019159 VANDF
C0030903 UMLSCUI
CHEBI:34910 CHEBI
CHEMBL116943 ChEMBL_ID
DB13415 DRUGBANK_ID
410 INN_ID
WM5Z385K7T UNII
5917 PUBCHEM_CID
8015 RXNORM
001379 NDDF
D010433 MESH_DESCRIPTOR_UI

Pharmaceutical products:

None