nikethamide 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | PK/Tox | Related Drugs | BioActivity |

Stem definitionDrug idCAS RN
nicotinic acid or nicotinoyl alcohol derivatives 3383 59-26-7

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • nikethamide
  • anacardone
  • anacordone
  • niamine
  • nicamide
  • nicetamide
  • nicethamide
  • nicorine
  • nicotinic acid diethylamide
  • carbamidal
  • pyricardyl
A central nervous system stimulant. It was formerly used in the treatment of barbiturate overdose but is now considered to be of no value for such purposes and may be dangerous. (From Martindale, The Extra Pharmacopoeia, 30th ed, p1229)
  • Molecular weight: 178.24
  • Formula: C10H14N2O
  • CLOGP: 0.56
  • LIPINSKI: 0
  • HAC: 3
  • HDO: 0
  • TPSA: 33.20
  • ALOGS: -0.21
  • ROTB: 3

Drug dosage:

DoseUnitRoute
0.50 g O
0.50 g P

ADMET properties:

None

Predicted pharmacokinetic/toxicological properties (PK-AZ):

PropertyDescriptionValueUnitConfidenceSimilarity
kinase-safety-class ACVR2A,ACVR2B,AXL,BRAF,CAMK2B,CAMK2D,CDK5,CDK9,DDR1,DYRK1B,EGFR,EIF2AK3,EPHB4,ERBB2,GRK2,ITK,MAPK7,MAPKAPK2,NTRK2,PDK1,PDK2,PDK4,PIK3CB,PRKDC,SIK2,SIK3,STK33,TEK 28
kinase-selectivity-class ACVR2B,AXL,BRAF,GRK2 4
pfas-class PFAS structural alert (1 = True, 0 = False) 0

Approvals:

None

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Peripheral circulatory failure 141.02 89.16 25 1835 1579 90625008
Parkinsonism 133.54 89.16 35 1825 14030 90612557
Blood cholesterol decreased 129.94 89.16 24 1836 1907 90624680
Neuroglycopenia 129.26 89.16 22 1838 1093 90625494
Gastric polyps 119.95 89.16 26 1834 4646 90621941
Initial insomnia 117.07 89.16 29 1831 9281 90617306
Stupor 110.37 89.16 25 1835 5457 90621130
Atrioventricular block first degree 109.47 89.16 27 1833 8484 90618103
Bradykinesia 105.05 89.16 25 1835 6763 90619824
Drug dependence 104.06 89.16 34 1826 29293 90597294
Dementia 102.51 89.16 32 1828 23829 90602758
Multiple drug therapy 99.11 89.16 24 1836 6985 90619602
Muscle rigidity 91.04 89.16 26 1834 14283 90612304

FDA Adverse Event Reporting System (Male)

None

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Peripheral circulatory failure 142.66 78.93 25 1849 1794 110585631
Neuroglycopenia 133.25 78.93 22 1852 1104 110586321
Blood cholesterol decreased 126.36 78.93 24 1850 2692 110584733
Parkinsonism 124.37 78.93 35 1839 22152 110565273
Gastric polyps 120.57 78.93 26 1848 5497 110581928
Initial insomnia 119.42 78.93 29 1845 10360 110577065
Stupor 104.92 78.93 25 1849 8240 110579185
Atrioventricular block first degree 100.84 78.93 27 1847 14198 110573227
Multiple drug therapy 100.48 78.93 24 1850 7990 110579435
Dementia 99.62 78.93 32 1842 31641 110555784
Bradykinesia 98.30 78.93 25 1849 10763 110576662
Drug dependence 92.66 78.93 34 1840 49986 110537439
Muscle rigidity 82.65 78.93 26 1848 24005 110563420
Hiatus hernia 79.11 78.93 26 1848 27580 110559845

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
ATC R07AB02 RESPIRATORY SYSTEM
OTHER RESPIRATORY SYSTEM PRODUCTS
OTHER RESPIRATORY SYSTEM PRODUCTS
Respiratory stimulants
ATC R07AB52 RESPIRATORY SYSTEM
OTHER RESPIRATORY SYSTEM PRODUCTS
OTHER RESPIRATORY SYSTEM PRODUCTS
Respiratory stimulants
MeSH PA D000697 Central Nervous System Stimulants
MeSH PA D003292 Convulsants

Related Drugs by ATC class:

R07AB Respiratory stimulants 8 drugs
almitrinebemegridedimeflinedoxaprametamivanmepixanoxpentetrazolprethcamide

Drug Use | Suggest Off label Use Form| |View source of the data|

None




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 3.0 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

None

External reference:

IDSource
N0000167328 NUI
D07408 KEGG_DRUG
C0028089 UMLSCUI
CHEBI:134814 CHEBI
CHEMBL2104607 ChEMBL_ID
DB13655 DRUGBANK_ID
D009552 MESH_DESCRIPTOR_UI
5497 PUBCHEM_CID
403 INN_ID
368IVD6M32 UNII
7424 RXNORM
001381 NDDF
387591002 SNOMEDCT_US
9690006 SNOMEDCT_US

Pharmaceutical products:

None