docusate sodium 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
941 10041-19-7

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • docusate
  • dioctyl sulfosuccinate
  • dioctyl sulfosuccinic acid
  • docusate sodium
  • docusate calcium
  • dioctyl disodium sulfosuccinate
All-purpose surfactant, wetting agent, and solubilizer used in the drug, cosmetics, and food industries. It has also been used in laxatives and as cerumenolytics. It is usually administered as either the calcium, potassium, or sodium salt.
  • Molecular weight: 422.58
  • Formula: C20H38O7S
  • CLOGP: 5.46
  • LIPINSKI: 1
  • HAC: 7
  • HDO: 1
  • TPSA: 106.97
  • ALOGS: -5.02
  • ROTB: 18

Drug dosage:

DoseUnitRoute
0.15 g O

ADMET properties:

None

Approvals:

DateAgencyCompanyOrphan
None FDA

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Drug ineffective 326.02 9.99 593 88455 818740 49697336
Constipation 295.70 9.99 855 88193 184853 50331223
Systemic lupus erythematosus 193.54 9.99 14 89034 140608 50375468
Pneumonia aspiration 193.00 9.99 255 88793 30749 50485327
Synovitis 177.39 9.99 10 89038 123855 50392221
Hand deformity 153.67 9.99 5 89043 100194 50415882
Maternal exposure during pregnancy 152.19 9.99 46 89002 159732 50356344
Contraindicated product administered 147.20 9.99 40 89008 148918 50367158
Gastrooesophageal reflux disease 139.25 9.99 370 88678 76058 50440018
Glossodynia 116.12 9.99 30 89018 115539 50400537
Therapeutic product effect decreased 116.10 9.99 47 89001 136003 50380073
Completed suicide 115.11 9.99 44 89004 131845 50384231
Plasma cell myeloma 106.62 9.99 195 88853 31127 50484949
Joint swelling 106.44 9.99 167 88881 245119 50270957
Arthropathy 106.19 9.99 74 88974 157832 50358244
Urinary tract infection 96.68 9.99 700 88348 223320 50292756
Treatment failure 91.87 9.99 65 88983 137572 50378504
Pulmonary embolism 89.90 9.99 386 88662 101318 50414758
Pericarditis 88.02 9.99 16 89032 78673 50437403
Drug intolerance 86.89 9.99 158 88890 218946 50297130
Deep vein thrombosis 82.37 9.99 300 88748 73004 50443072
Discomfort 82.30 9.99 44 89004 108336 50407740
Mental status changes 79.01 9.99 188 88860 36084 50479992
Off label use 77.11 9.99 504 88544 473922 50042154
Wound 73.21 9.99 48 89000 105746 50410330
Swelling 72.58 9.99 153 88895 200719 50315357
Alopecia 70.39 9.99 210 88838 244837 50271239
Rheumatoid arthritis 70.11 9.99 158 88890 202392 50313684
Duodenal ulcer perforation 67.43 9.99 3 89045 45608 50470468
Abdominal pain 66.36 9.99 671 88377 235557 50280519
Pneumonia 65.55 9.99 981 88067 377420 50138656
Anti-neutrophil cytoplasmic antibody positive vasculitis 62.30 9.99 43 89005 2279 50513797
Salpingo-oophorectomy unilateral 60.95 9.99 26 89022 515 50515561
Pulmonary malformation 60.48 9.99 20 89028 187 50515889
Coma 58.25 9.99 226 88822 56653 50459423
Helicobacter infection 58.03 9.99 9 89039 49693 50466383
Asthenia 57.52 9.99 833 88215 318209 50197867
Sinusitis fungal 57.23 9.99 33 89015 1273 50514803
Somnolence 56.58 9.99 466 88582 154519 50361557
Product use issue 56.39 9.99 111 88937 149364 50366712
Exposure during pregnancy 55.71 9.99 79 88969 120936 50395140
Death 55.70 9.99 842 88206 324537 50191539
Drug hypersensitivity 54.92 9.99 241 88807 250769 50265307
Chronic sinusitis 53.64 9.99 60 88988 6085 50509991
Toxicity to various agents 53.47 9.99 193 88855 212306 50303770
Drug interaction 52.44 9.99 178 88870 199443 50316633
Arthralgia 52.21 9.99 507 88541 438195 50077881
Dehydration 51.75 9.99 451 88597 151998 50364078
Back pain 51.15 9.99 602 88446 219428 50296648
Sputum increased 51.10 9.99 35 89013 1832 50514244
Intentional overdose 51.04 9.99 23 89025 62481 50453595
Pleural effusion 50.93 9.99 280 88768 81174 50434902
Full blood count decreased 48.85 9.99 116 88932 22230 50493846
Hepatic enzyme increased 48.46 9.99 106 88942 137274 50378802
Folliculitis 48.39 9.99 6 89042 39219 50476857
Abdominal discomfort 47.92 9.99 227 88821 231414 50284662
Disease progression 46.83 9.99 309 88739 95557 50420519
Hiatus hernia 46.52 9.99 101 88947 18243 50497833
Drug abuse 45.85 9.99 24 89024 59822 50456254
Condition aggravated 45.43 9.99 321 88727 296737 50219339
C-reactive protein increased 44.85 9.99 31 89017 66443 50449633
Intestinal pseudo-obstruction 43.94 9.99 23 89025 731 50515345
Psoriatic arthropathy 43.91 9.99 14 89034 47018 50469058
Nausea 43.90 9.99 1583 87465 703815 49812261
Embolism venous 43.77 9.99 36 89012 2489 50513587
Lung cyst 43.68 9.99 15 89033 159 50515917
Oedema peripheral 43.48 9.99 447 88601 157514 50358562
Nasal polyps 43.41 9.99 36 89012 2518 50513558
Small intestinal obstruction 42.50 9.99 90 88958 15978 50500098
Irritable bowel syndrome 41.89 9.99 19 89029 51422 50464654
Therapeutic product effect incomplete 41.86 9.99 60 88988 91455 50424621
Respiratory symptom 40.97 9.99 34 89014 2380 50513696
Sleep disorder due to general medical condition, insomnia type 40.84 9.99 4 89044 31443 50484633
Diverticulum 39.86 9.99 69 88979 10545 50505531
Haemoglobin decreased 37.91 9.99 366 88682 126850 50389226
Failure to thrive 37.56 9.99 51 88997 6307 50509769
Suicide attempt 36.42 9.99 23 89025 51709 50464367
Cestode infection 36.37 9.99 15 89033 272 50515804
White blood cell count decreased 36.36 9.99 339 88709 116383 50399693
Diastolic dysfunction 35.14 9.99 45 89003 5257 50510819
Female genital tract fistula 34.08 9.99 37 89011 3629 50512447
General physical health deterioration 33.44 9.99 133 88915 142301 50373775
Chest pain 33.05 9.99 465 88583 176417 50339659
Hypoxia 32.12 9.99 176 88872 50947 50465129
Tricuspid valve incompetence 32.02 9.99 70 88978 12700 50503376
Rash 31.86 9.99 560 88488 436911 50079165
Infusion related reaction 31.71 9.99 172 88876 169385 50346691
Magnesium deficiency 31.29 9.99 16 89032 484 50515592
Infection 30.96 9.99 178 88870 172776 50343300
Hospice care 30.67 9.99 44 89004 5728 50510348
Hip fracture 29.84 9.99 107 88941 25824 50490252
Cardiac failure congestive 29.84 9.99 252 88796 84130 50431946
Injection site pain 29.81 9.99 98 88950 110926 50405150
Lethargy 29.61 9.99 168 88880 49264 50466812
Vomiting 29.02 9.99 1036 88012 459722 50056354
Abortion spontaneous 28.82 9.99 19 89029 41753 50474323
Injection site erythema 28.80 9.99 55 88993 74881 50441195
Peritonitis bacterial 28.47 9.99 38 89010 4623 50511453
Injection site pruritus 28.40 9.99 18 89030 40393 50475683
Premenstrual syndrome 28.25 9.99 16 89032 596 50515480
Fall 28.16 9.99 780 88268 334152 50181924
Lip pruritus 27.92 9.99 17 89031 726 50515350
Product use in unapproved indication 27.27 9.99 108 88940 115711 50400365
Injection site reaction 26.86 9.99 29 89019 50003 50466073
Hypervolaemia 26.65 9.99 102 88946 25397 50490679
Platelet count decreased 26.26 9.99 282 88766 100444 50415632
Injection site swelling 26.21 9.99 21 89027 41752 50474324
Fungal infection 25.88 9.99 113 88935 29852 50486224
Autonomic dysreflexia 24.89 9.99 12 89036 319 50515757
Device expulsion 24.49 9.99 10 89038 28812 50487264
Emphysema 24.13 9.99 51 88997 9042 50507034
Polymenorrhoea 23.92 9.99 18 89030 1093 50514983
Red blood cell sedimentation rate increased 23.74 9.99 11 89037 29405 50486671
Acute respiratory failure 23.70 9.99 107 88941 28675 50487401
Lichen sclerosus 23.55 9.99 17 89031 968 50515108
Interstitial lung disease 23.20 9.99 36 89012 53140 50462936
Drug resistance 23.19 9.99 3 89045 18986 50497090
Carbohydrate antigen 125 increased 23.11 9.99 25 89023 2442 50513634
Blood potassium decreased 23.08 9.99 127 88921 36818 50479258
Febrile neutropenia 22.99 9.99 268 88780 97399 50418677
Respiratory tract malformation 22.95 9.99 8 89040 89 50515987
Dyspnoea 22.72 9.99 1179 87869 546429 49969647
Atrial fibrillation 22.55 9.99 276 88772 101469 50414607
Knee arthroplasty 22.52 9.99 18 89030 35828 50480248
Drug reaction with eosinophilia and systemic symptoms 22.37 9.99 11 89037 28413 50487663
Neutrophil count decreased 22.24 9.99 148 88900 45878 50470198
Maternal exposure during breast feeding 22.17 9.99 28 89020 3226 50512850
International normalised ratio increased 21.61 9.99 140 88908 43012 50473064
Accidental exposure to product 21.28 9.99 7 89041 23050 50493026
Cellulitis 21.22 9.99 204 88844 70594 50445482
Unresponsive to stimuli 21.02 9.99 108 88940 30501 50485575
Granulocytopenia 20.96 9.99 35 89013 5196 50510880
Abdominal distension 20.84 9.99 208 88840 72695 50443381
Iron deficiency anaemia 20.70 9.99 71 88977 16763 50499313
Psoriasis 20.59 9.99 58 88990 68942 50447134
Anaemia 20.37 9.99 585 88463 251871 50264205
Hysterectomy 19.50 9.99 43 89005 7847 50508229
Impaired healing 19.14 9.99 61 88987 69725 50446351
Sleep apnoea syndrome 19.10 9.99 88 88960 23780 50492296
Fatigue 18.97 9.99 1467 87581 706134 49809942
Lactation disorder 18.93 9.99 10 89038 324 50515752
Liver injury 18.92 9.99 10 89038 24796 50491280
Hyponatraemia 18.85 9.99 255 88793 95884 50420192
Exposure via breast milk 18.14 9.99 18 89030 1590 50514486
Gastrointestinal disorder 18.10 9.99 95 88953 94361 50421715
Premature baby 17.95 9.99 5 89043 18332 50497744
Neuropathy peripheral 17.90 9.99 254 88794 96503 50419573
Decreased appetite 17.72 9.99 471 88577 200452 50315624
Gastrointestinal haemorrhage 17.61 9.99 202 88846 73119 50442957
Chronic obstructive pulmonary disease 17.54 9.99 157 88891 53278 50462798
Hypersensitivity 17.39 9.99 270 88778 214891 50301185
Onychoclasis 17.23 9.99 32 89016 5164 50510912
Respiratory failure 17.12 9.99 240 88808 90941 50425135
Overdose 17.11 9.99 104 88944 99623 50416453
Hypophagia 17.10 9.99 95 88953 27633 50488443
Live birth 16.97 9.99 4 89044 16404 50499672
Body temperature fluctuation 16.77 9.99 19 89029 1954 50514122
Dysmetropsia 16.58 9.99 6 89042 75 50516001
Noninfectious peritonitis 16.58 9.99 7 89041 135 50515941
Lower gastrointestinal haemorrhage 16.45 9.99 37 89011 6842 50509234
Flatulence 16.26 9.99 98 88950 29360 50486716
Menstruation delayed 16.11 9.99 16 89032 1415 50514661
Pregnancy 16.03 9.99 17 89031 29560 50486516
Hip arthroplasty 15.93 9.99 18 89030 30411 50485665
Drug eruption 15.93 9.99 11 89037 23595 50492481
Uterine perforation 15.90 9.99 35 89013 6380 50509696
Thrombosis 15.81 9.99 159 88889 55674 50460402
Blister 15.76 9.99 87 88961 85331 50430745
Immune-mediated encephalitis 15.53 9.99 6 89042 91 50515985
Musculoskeletal stiffness 15.41 9.99 148 88900 128333 50387743
Duodenal stenosis 15.26 9.99 10 89038 486 50515590
Mobility decreased 14.99 9.99 81 88967 79867 50436209
Dysphagia 14.94 9.99 205 88843 77313 50438763
Cytokine release syndrome 14.90 9.99 41 89007 8593 50507483
Haematocrit decreased 14.86 9.99 109 88939 34867 50481209
Electrocardiogram PR prolongation 14.85 9.99 11 89037 652 50515424
Cholelithiasis 14.82 9.99 116 88932 37857 50478219
Urinary retention postoperative 14.39 9.99 5 89043 55 50516021
Intentional product misuse 14.15 9.99 39 89009 46695 50469381
Oesophageal ulcer 13.98 9.99 25 89023 3920 50512156
Multiple sclerosis 13.85 9.99 72 88976 20421 50495655
Emotional distress 13.74 9.99 92 88956 28571 50487505
Atelectasis 13.63 9.99 66 88982 18204 50497872
Non-small cell lung cancer 13.61 9.99 21 89027 2916 50513160
Rectal haemorrhage 13.54 9.99 115 88933 38443 50477633
Excessive eye blinking 13.37 9.99 12 89036 934 50515142
Hypotension 13.21 9.99 523 88525 234946 50281130
Injection site warmth 13.17 9.99 4 89044 13862 50502214
Proteinuria 13.14 9.99 61 88987 16536 50499540
Injection site rash 13.13 9.99 6 89042 16171 50499905
Gingival pain 12.93 9.99 31 89017 5975 50510101
Faeces hard 12.88 9.99 15 89033 1589 50514487
Intentional self-injury 12.85 9.99 13 89035 23099 50492977
Anaphylactic shock 12.81 9.99 10 89038 20145 50495931
Sepsis 12.71 9.99 315 88733 132610 50383466
Polyneuropathy 12.46 9.99 3 89045 12128 50503948
Blood loss anaemia 12.44 9.99 37 89011 8102 50507974
Fluid retention 12.36 9.99 140 88908 50509 50465567
Anaphylactic reaction 12.34 9.99 51 88997 54004 50462072
Cholecystitis chronic 12.08 9.99 41 89007 9628 50506448
Cardiac murmur 11.98 9.99 44 89004 10740 50505336
Gastrointestinal arteriovenous malformation 11.95 9.99 9 89039 547 50515529
Epistaxis 11.87 9.99 168 88880 63786 50452290
Decubitus ulcer 11.82 9.99 40 89008 9378 50506698
Calculus bladder 11.77 9.99 9 89039 560 50515516
Urticaria 11.71 9.99 159 88889 129402 50386674
Intestinal obstruction 11.66 9.99 83 88965 26300 50489776
Malignant neoplasm of thorax 11.65 9.99 3 89045 10 50516066
Ill-defined disorder 11.60 9.99 53 88995 54601 50461475
Sinus bradycardia 11.60 9.99 50 88998 13133 50502943
Rhabdomyolysis 11.50 9.99 33 89015 38994 50477082
Rubber sensitivity 11.44 9.99 15 89033 1794 50514282
Red blood cell count decreased 11.40 9.99 100 88948 33735 50482341
Upper respiratory tract infection 11.40 9.99 171 88877 65727 50450349
Drug-induced liver injury 11.34 9.99 20 89028 28075 50488001
Abdominal mass 11.34 9.99 18 89030 2561 50513515
Arteriovenous graft site infection 11.23 9.99 3 89045 12 50516064
Therapy non-responder 11.12 9.99 49 88999 50973 50465103
Blood bilirubin decreased 10.84 9.99 9 89039 630 50515446
Laboratory test abnormal 10.83 9.99 74 88974 23134 50492942
Urinary tract infection enterococcal 10.72 9.99 17 89031 2417 50513659
Mean platelet volume increased 10.70 9.99 8 89040 481 50515595
Grip strength decreased 10.64 9.99 4 89044 12117 50503959
Foetal exposure during pregnancy 10.58 9.99 20 89028 27339 50488737
Injury 10.52 9.99 132 88916 48793 50467283
Hyperaesthesia 10.51 9.99 35 89013 8138 50507938
Weight decreased 10.51 9.99 483 88565 220762 50295314
Candida infection 10.39 9.99 74 88974 23449 50492627
Pulmonary hypertension 10.36 9.99 97 88951 33320 50482756
Intentional product use issue 10.36 9.99 86 88962 76832 50439244
Burkholderia test positive 10.35 9.99 6 89042 234 50515842
Haemorrhoids 10.27 9.99 63 88985 18990 50497086
Cardiac failure 10.25 9.99 85 88963 75955 50440121
Enterocele 10.22 9.99 4 89044 63 50516013
Confusional state 10.19 9.99 412 88636 185516 50330560

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Constipation 168.08 10.17 564 59874 113596 29400493
Drug ineffective 147.77 10.17 328 60110 362842 29151247
Completed suicide 113.76 10.17 23 60415 90223 29423866
Plasma cell myeloma 100.09 10.17 229 60209 36886 29477203
Drug abuse 84.29 10.17 29 60409 79854 29434235
Mental status changes 66.54 10.17 189 60249 34738 29479351
Urinary tract infection 65.36 10.17 307 60131 72047 29442042
Off label use 62.64 10.17 360 60078 300440 29213649
Pneumonia 54.10 10.17 936 59502 319236 29194853
Toxicity to various agents 48.96 10.17 186 60252 173475 29340614
Fatigue 48.49 10.17 912 59526 315909 29198180
Fall 44.43 10.17 555 59883 176623 29337466
Confusional state 44.22 10.17 427 60011 127450 29386639
Death 43.17 10.17 957 59481 341127 29172962
Intentional overdose 42.36 10.17 13 60425 38515 29475574
Hepatic function abnormal 41.82 10.17 14 60424 39245 29474844
Failure to thrive 41.65 10.17 64 60374 7620 29506469
Dehydration 40.57 10.17 385 60053 114363 29399726
Burkholderia test positive 37.19 10.17 24 60414 975 29513114
Hallucination 36.24 10.17 184 60254 44528 29469561
Interstitial lung disease 34.75 10.17 40 60398 57678 29456411
Drug interaction 34.45 10.17 249 60189 197136 29316953
Therapeutic product effect incomplete 33.96 10.17 19 60419 39286 29474803
Product use in unapproved indication 33.84 10.17 80 60358 86795 29427294
Asthenia 33.64 10.17 622 59816 214628 29299461
Walking aid user 33.01 10.17 26 60412 1451 29512638
Failure to suspend medication 32.71 10.17 16 60422 376 29513713
Hypersomnia 31.94 10.17 69 60369 10685 29503404
Full blood count decreased 31.87 10.17 88 60350 15904 29498185
C-reactive protein increased 29.65 10.17 28 60410 44235 29469854
Painful respiration 29.15 10.17 22 60416 1152 29512937
Accidental death 28.61 10.17 28 60410 2090 29511999
Deep vein thrombosis 28.51 10.17 208 60230 57191 29456898
Drug resistance 28.16 10.17 5 60433 21535 29492554
Peripheral swelling 27.77 10.17 224 60214 63515 29450574
Treatment failure 27.64 10.17 21 60417 36918 29477171
Disease progression 27.04 10.17 271 60167 81645 29432444
Febrile neutropenia 26.56 10.17 348 60090 111892 29402197
Unresponsive to stimuli 25.95 10.17 111 60327 25015 29489074
Cholestasis 25.64 10.17 8 60430 23454 29490635
Hepatocellular injury 25.55 10.17 6 60432 21237 29492852
Chest injury 25.30 10.17 22 60416 1411 29512678
Coma 25.22 10.17 26 60412 39424 29474665
Renal impairment 24.94 10.17 84 60354 81249 29432840
Granulocytopenia 24.52 10.17 44 60394 5950 29508139
Overdose 23.42 10.17 84 60354 79735 29434354
Small intestinal obstruction 23.24 10.17 69 60369 12992 29501097
Hospice care 23.07 10.17 39 60399 5029 29509060
Condition aggravated 22.94 10.17 190 60248 146105 29367984
General physical health deterioration 21.89 10.17 122 60316 102735 29411354
Muscle spasticity 21.47 10.17 37 60401 4846 29509243
Peripheral artery thrombosis 21.40 10.17 24 60414 2098 29511991
Spinal fracture 20.87 10.17 43 60395 6443 29507646
Drug reaction with eosinophilia and systemic symptoms 20.83 10.17 16 60422 27976 29486113
Skin turgor decreased 20.49 10.17 12 60426 409 29513680
Metabolic encephalopathy 20.39 10.17 31 60407 3656 29510433
Hypoxia 19.82 10.17 165 60273 47214 29466875
Pathological fracture 19.35 10.17 31 60407 3824 29510265
Gangrene neonatal 19.19 10.17 9 60429 192 29513897
Paraneoplastic rash 18.89 10.17 7 60431 80 29514009
Hypotension 18.52 10.17 524 59914 193830 29320259
Back pain 17.86 10.17 301 60137 101983 29412106
Foetal exposure during pregnancy 17.77 10.17 26 60412 33841 29480248
Vomiting 17.72 10.17 563 59875 211697 29302392
Dry skin 17.55 10.17 94 60344 23213 29490876
Rheumatoid arthritis 17.55 10.17 24 60414 32128 29481961
Hypoacusis 17.50 10.17 67 60371 14356 29499733
Eosinophilia 17.36 10.17 12 60426 22149 29491940
Epilepsy 17.28 10.17 8 60430 18424 29495665
Peritonitis bacterial 17.17 10.17 37 60401 5719 29508370
White blood cell count decreased 17.08 10.17 252 60186 83110 29430979
Premature baby 16.99 10.17 7 60431 17273 29496816
Haematocrit decreased 16.67 10.17 109 60329 28913 29485176
Gamma-glutamyltransferase increased 16.66 10.17 18 60420 26719 29487370
Sitting disability 16.38 10.17 7 60431 119 29513970
Moaning 16.31 10.17 13 60425 738 29513351
Multiple organ dysfunction syndrome 16.23 10.17 70 60368 63046 29451043
Suicide attempt 16.18 10.17 28 60410 34082 29480007
Ageusia 15.69 10.17 47 60391 8891 29505198
Sepsis 15.67 10.17 392 60046 142290 29371799
Anaphylactic shock 15.58 10.17 4 60434 13332 29500757
Contraindicated product administered 15.53 10.17 9 60429 18257 29495832
Neuropathy peripheral 15.46 10.17 217 60221 70810 29443279
Decubitus ulcer 15.34 10.17 41 60397 7270 29506819
Paratracheal lymphadenopathy 15.29 10.17 6 60432 81 29514008
Metastatic renal cell carcinoma 15.04 10.17 19 60419 1883 29512206
Muscle spasms 14.63 10.17 200 60238 64882 29449207
Pleural effusion 14.58 10.17 217 60221 71691 29442398
Oral pustule 14.49 10.17 8 60430 243 29513846
Cellulitis 14.32 10.17 150 60288 45690 29468399
Cytomegalovirus infection 14.06 10.17 16 60422 23199 29490890
Pulmonary embolism 14.01 10.17 227 60211 76307 29437782
Myelosuppression 13.66 10.17 4 60434 12223 29501866
Urosepsis 13.11 10.17 50 60388 10696 29503393
Accidental exposure to product 13.00 10.17 3 60435 10750 29503339
Blood potassium decreased 12.91 10.17 65 60373 15669 29498420
Urinary incontinence 12.77 10.17 67 60371 16414 29497675
Hypervolaemia 12.70 10.17 70 60368 17475 29496614
Nausea 12.68 10.17 717 59721 288538 29225551
Intentional product misuse 12.64 10.17 33 60405 34628 29479461
Injection site pain 12.52 10.17 30 60408 32416 29481673
Body height decreased 12.45 10.17 24 60414 3426 29510663
Weight decrease neonatal 12.40 10.17 8 60430 325 29513764
Intentional self-injury 12.33 10.17 5 60433 12456 29501633
Wrong technique in product usage process 12.18 10.17 29 60409 31399 29482690
Maternal exposure during breast feeding 12.00 10.17 15 60423 1471 29512618
Injection site reaction 11.89 10.17 4 60434 11184 29502905
Seizure like phenomena 11.84 10.17 10 60428 616 29513473
Labelled drug-drug interaction medication error 11.84 10.17 5 60433 12154 29501935
Toxic epidermal necrolysis 11.56 10.17 12 60426 18141 29495948
Rib fracture 11.49 10.17 54 60384 12664 29501425
Synovitis 11.39 10.17 4 60434 10886 29503203
Inflammation 11.39 10.17 18 60420 22710 29491379
Thrombosis 11.24 10.17 136 60302 42909 29471180
Urinary retention 11.23 10.17 107 60331 31791 29482298
Decreased appetite 11.20 10.17 382 60056 144960 29369129
Aortic aneurysm 11.20 10.17 33 60405 6187 29507902
Bacteraemia 11.07 10.17 64 60374 16259 29497830
Sexually inappropriate behaviour 11.03 10.17 8 60430 394 29513695
Wrong patient received product 10.98 10.17 18 60420 2264 29511825
Muscular weakness 10.96 10.17 183 60255 61869 29452220
Bone marrow failure 10.90 10.17 25 60413 27424 29486665
Metabolic acidosis 10.80 10.17 40 60398 37622 29476467
Oral candidiasis 10.78 10.17 47 60391 10675 29503414
Band neutrophil percentage increased 10.69 10.17 5 60433 106 29513983
Red blood cell count decreased 10.61 10.17 89 60349 25513 29488576
Refusal of treatment by patient 10.54 10.17 27 60411 4667 29509422
Pain 10.44 10.17 439 59999 170993 29343096
Postictal state 10.40 10.17 10 60428 730 29513359
Cardiac disorder 10.29 10.17 119 60319 37144 29476945
Product prescribing error 10.24 10.17 13 60425 17963 29496126
Therapeutic response decreased 10.23 10.17 22 60416 24689 29489400

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Drug ineffective 313.70 9.84 677 118067 839570 63540418
Constipation 283.27 9.84 997 117747 228340 64151648
Completed suicide 228.45 9.84 65 118679 224349 64155639
Plasma cell myeloma 151.50 9.84 290 118454 45785 64334203
Synovitis 146.47 9.84 9 118735 99081 64280907
Toxicity to various agents 129.92 9.84 299 118445 363214 64016774
Urinary tract infection 127.88 9.84 796 117948 230800 64149188
Mental status changes 125.97 9.84 319 118425 60843 64319145
Drug abuse 119.51 9.84 47 118697 132327 64247661
Pneumonia aspiration 113.69 9.84 301 118443 58970 64321018
Off label use 111.93 9.84 695 118049 632111 63747877
Gastrooesophageal reflux disease 111.61 9.84 372 118372 82771 64297217
Systemic lupus erythematosus 101.23 9.84 12 118732 77600 64302388
Hand deformity 94.91 9.84 5 118739 62766 64317222
Pulmonary embolism 94.25 9.84 524 118220 145832 64234156
Deep vein thrombosis 93.67 9.84 413 118331 104769 64275219
Death 92.13 9.84 1321 117423 481384 63898604
Contraindicated product administered 86.83 9.84 45 118699 107784 64272204
Pneumonia 83.98 9.84 1471 117273 558105 63821883
Intentional overdose 81.06 9.84 32 118712 89912 64290076
Maternal exposure during pregnancy 78.72 9.84 39 118705 95845 64284143
Failure to thrive 77.92 9.84 96 118648 10308 64369680
Therapeutic product effect decreased 77.90 9.84 59 118685 115292 64264696
Joint swelling 70.67 9.84 185 118559 215197 64164791
Treatment failure 70.02 9.84 67 118677 116749 64263239
Drug interaction 64.16 9.84 397 118347 361686 64018302
Arthropathy 64.02 9.84 77 118667 120890 64259098
C-reactive protein increased 62.24 9.84 50 118694 94859 64285129
Disease progression 60.28 9.84 457 118287 141223 64238765
Febrile neutropenia 60.09 9.84 568 118176 187089 64192899
Dehydration 59.26 9.84 635 118109 216128 64163860
Pericarditis 58.41 9.84 21 118723 62495 64317493
Drug intolerance 57.54 9.84 167 118577 187825 64192163
Small intestinal obstruction 57.16 9.84 131 118613 23442 64356546
Hepatocellular injury 56.56 9.84 8 118736 45227 64334761
Asthenia 55.66 9.84 1101 117643 426943 63953045
Salpingo-oophorectomy unilateral 55.37 9.84 24 118720 472 64379516
Discomfort 52.54 9.84 43 118701 80835 64299153
Condition aggravated 52.53 9.84 436 118308 371990 64007998
Granulocytopenia 51.90 9.84 79 118665 10361 64369627
Product use in unapproved indication 50.40 9.84 162 118582 176456 64203532
Hypoxia 49.81 9.84 305 118439 87844 64292144
Rheumatoid arthritis 49.50 9.84 147 118597 164147 64215841
Interstitial lung disease 47.79 9.84 66 118678 97666 64282322
Suicide attempt 47.06 9.84 37 118707 70970 64309018
Abdominal pain 46.62 9.84 821 117923 311554 64068434
Duodenal ulcer perforation 46.03 9.84 5 118739 34620 64345368
Therapeutic product effect incomplete 45.65 9.84 75 118669 103407 64276581
Hospice care 45.64 9.84 63 118681 7562 64372426
General physical health deterioration 45.13 9.84 208 118536 204217 64175771
Glossodynia 45.08 9.84 32 118712 64664 64315324
Pleural effusion 45.04 9.84 392 118352 126167 64253821
Drug resistance 44.38 9.84 6 118738 35096 64344892
Fatigue 44.30 9.84 1740 117004 746990 63632998
Unresponsive to stimuli 44.17 9.84 197 118547 50196 64329792
Fall 44.15 9.84 1041 117703 415785 63964203
Back pain 43.78 9.84 675 118069 249496 64130492
Sinusitis fungal 43.12 9.84 31 118713 1675 64378313
Peritonitis bacterial 42.95 9.84 67 118677 8976 64371012
Confusional state 41.72 9.84 694 118050 260450 64119538
Anti-neutrophil cytoplasmic antibody positive vasculitis 41.52 9.84 38 118706 2898 64377090
Pulmonary malformation 41.42 9.84 14 118730 134 64379854
Nausea 41.21 9.84 1803 116941 783997 63595991
Helicobacter infection 41.09 9.84 10 118734 38352 64341636
Chronic sinusitis 40.72 9.84 54 118690 6238 64373750
Full blood count decreased 40.59 9.84 112 118632 22470 64357518
Exposure during pregnancy 40.50 9.84 50 118694 77625 64302363
Injection site pain 39.40 9.84 92 118652 111316 64268672
Hiatus hernia 38.91 9.84 102 118642 19855 64360133
Drug hypersensitivity 38.90 9.84 267 118477 237548 64142440
Drug reaction with eosinophilia and systemic symptoms 37.54 9.84 27 118717 54190 64325798
Haemoglobin decreased 36.71 9.84 533 118211 194530 64185458
Oedema peripheral 36.60 9.84 567 118177 209750 64170238
Cestode infection 36.18 9.84 15 118729 263 64379725
Vomiting 35.44 9.84 1293 117451 549824 63830164
Overdose 35.42 9.84 162 118582 159404 64220584
Hepatic function abnormal 35.02 9.84 40 118704 64273 64315715
Female genital tract fistula 34.88 9.84 33 118711 2625 64377363
Sepsis 34.54 9.84 606 118138 229735 64150253
Intestinal pseudo-obstruction 34.54 9.84 29 118715 1971 64378017
White blood cell count decreased 34.49 9.84 443 118301 157394 64222594
Sleep disorder due to general medical condition, insomnia type 34.40 9.84 4 118740 26266 64353722
Folliculitis 33.91 9.84 7 118737 30070 64349918
Autonomic dysreflexia 33.51 9.84 16 118728 397 64379591
Hypervolaemia 33.05 9.84 149 118595 38136 64341852
Alopecia 32.87 9.84 175 118569 165515 64214473
Respiratory symptom 32.82 9.84 34 118710 3019 64376969
Hypersomnia 32.71 9.84 95 118649 19622 64360366
Injection site reaction 32.62 9.84 23 118721 46641 64333347
Product use issue 32.51 9.84 156 118588 151559 64228429
Arthralgia 32.47 9.84 596 118148 441664 63938324
Muscle injury 32.30 9.84 5 118739 26432 64353556
Lung cyst 32.28 9.84 12 118732 155 64379833
Hepatic enzyme increased 31.86 9.84 127 118617 129816 64250172
Cellulitis 31.71 9.84 287 118457 93370 64286618
Sputum increased 31.27 9.84 36 118708 3599 64376389
Dyspnoea 30.83 9.84 1617 117127 717057 63662931
Failure to suspend medication 30.77 9.84 15 118729 390 64379598
Psoriatic arthropathy 30.69 9.84 21 118723 43260 64336728
Injection site erythema 30.59 9.84 52 118692 70748 64309240
Cholestasis 30.22 9.84 23 118721 44849 64335139
Lethargy 30.20 9.84 233 118511 72361 64307627
Premenstrual syndrome 29.90 9.84 16 118728 508 64379480
Intentional product misuse 29.52 9.84 55 118689 72240 64307748
Irritable bowel syndrome 29.47 9.84 16 118728 37353 64342635
Injection site swelling 29.41 9.84 20 118724 41333 64338655
Acute respiratory failure 28.98 9.84 174 118570 49760 64330228
Embolism venous 28.94 9.84 34 118710 3473 64376515
Diverticulum 28.37 9.84 70 118674 13128 64366860
Myelosuppression 28.02 9.84 5 118739 23825 64356163
Wound 27.97 9.84 62 118682 76415 64303573
Haematocrit decreased 27.71 9.84 184 118560 54471 64325517
Hypotension 26.97 9.84 904 117840 380070 63999918
Hip fracture 26.88 9.84 110 118634 26989 64352999
Blood potassium decreased 26.87 9.84 146 118598 40253 64339735
Polymenorrhoea 26.42 9.84 18 118726 892 64379096
Maternal exposure during breast feeding 26.40 9.84 25 118719 1991 64377997
Nasal polyps 26.39 9.84 33 118711 3596 64376392
Magnesium deficiency 26.12 9.84 15 118729 548 64379440
Neutrophil count decreased 25.85 9.84 236 118508 76960 64303028
Chest pain 25.74 9.84 592 118152 235388 64144600
Burkholderia test positive 25.73 9.84 15 118729 564 64379424
Lip pruritus 25.49 9.84 16 118728 689 64379299
Diastolic dysfunction 24.54 9.84 52 118692 8823 64371165
Infection 24.42 9.84 220 118524 184660 64195328
Accidental exposure to product 24.38 9.84 9 118735 26355 64353633
Lichen sclerosus 24.29 9.84 17 118727 880 64379108
Injection site pruritus 23.47 9.84 21 118723 37805 64342183
Somnolence 22.86 9.84 513 118231 203132 64176856
Anaphylactic shock 22.48 9.84 14 118730 30314 64349674
Renal impairment 22.35 9.84 151 118593 134866 64245122
Therapeutic response decreased 21.93 9.84 39 118705 52149 64327839
Bone marrow failure 21.85 9.84 34 118710 47918 64332070
Hyponatraemia 21.76 9.84 389 118355 147950 64232038
Atrial fibrillation 21.46 9.84 438 118306 170651 64209337
Swelling 21.44 9.84 190 118554 160028 64219960
Walking aid user 21.21 9.84 40 118704 6241 64373747
Hypophagia 21.12 9.84 135 118609 39452 64340536
Dysphagia 20.93 9.84 294 118450 106518 64273470
Decubitus ulcer 20.80 9.84 63 118681 13316 64366672
Abdominal distension 20.77 9.84 269 118475 95725 64284263
Chest injury 20.77 9.84 24 118720 2409 64377579
Emphysema 20.71 9.84 65 118679 14004 64365984
Hallucination 20.68 9.84 215 118529 72573 64307415
Gastrointestinal disorder 20.54 9.84 90 118654 89619 64290369
Osteonecrosis of jaw 20.37 9.84 26 118718 39799 64340189
Drug eruption 20.19 9.84 22 118722 36114 64343874
Tricuspid valve incompetence 20.12 9.84 73 118671 16930 64363058
Urinary incontinence 19.73 9.84 124 118620 36027 64343961
Wrong technique in product usage process 19.65 9.84 58 118686 64916 64315072
Paraneoplastic rash 19.60 9.84 7 118737 80 64379908
Cardiac failure congestive 19.36 9.84 343 118401 130237 64249751
Lactic acidosis 19.17 9.84 54 118690 61356 64318632
Urticaria 18.72 9.84 177 118567 147140 64232848
Red blood cell sedimentation rate increased 18.60 9.84 18 118726 31217 64348771
Menstruation delayed 18.37 9.84 16 118728 1143 64378845
Gastrointestinal haemorrhage 18.37 9.84 344 118400 131968 64248020
Cytomegalovirus infection 18.30 9.84 25 118719 37174 64342814
Abortion spontaneous 18.09 9.84 12 118732 25131 64354857
Metabolic encephalopathy 17.72 9.84 43 118701 7982 64372006
International normalised ratio increased 17.61 9.84 223 118521 78944 64301044
Lactation disorder 17.35 9.84 8 118736 183 64379805
Red blood cell count decreased 17.26 9.84 150 118594 48236 64331752
Inflammation 17.18 9.84 62 118682 65238 64314750
Uterine perforation 17.15 9.84 35 118709 5785 64374203
Atelectasis 17.11 9.84 97 118647 27169 64352819
Product prescribing error 17.05 9.84 24 118720 35245 64344743
Epilepsy 17.04 9.84 22 118722 33509 64346479
Fluid retention 16.90 9.84 176 118568 59430 64320558
Exposure via breast milk 16.87 9.84 13 118731 781 64379207
Accidental death 16.86 9.84 27 118717 3698 64376290
Hysterectomy 16.70 9.84 32 118712 5053 64374935
Labelled drug-drug interaction medication error 16.61 9.84 10 118734 22052 64357936
Decreased appetite 16.58 9.84 654 118090 280635 64099353
Respiratory failure 16.53 9.84 401 118343 160782 64219206
Acute generalised exanthematous pustulosis 16.42 9.84 3 118741 14055 64365933
Pregnancy 16.36 9.84 9 118735 20856 64359132
Poisoning 16.35 9.84 10 118734 21869 64358119
Painful respiration 16.29 9.84 24 118720 3057 64376931
Platelet count decreased 16.23 9.84 414 118330 167297 64212691
Metastatic renal cell carcinoma 16.02 9.84 20 118724 2176 64377812
Intentional self-injury 15.88 9.84 18 118726 29026 64350962
Arthritis 15.80 9.84 90 118654 83724 64296264
Calculus bladder 15.73 9.84 15 118729 1205 64378783
Respiratory tract malformation 15.70 9.84 5 118739 39 64379949
Cholelithiasis 15.68 9.84 140 118604 45366 64334622
Sitting disability 15.64 9.84 7 118737 149 64379839
Dysmetropsia 15.64 9.84 6 118738 85 64379903
Gamma-glutamyltransferase increased 15.63 9.84 42 118702 48468 64331520
Fungal infection 15.41 9.84 112 118632 34139 64345849
Psoriasis 15.19 9.84 74 118670 71629 64308359
Cytokine release syndrome 15.03 9.84 77 118667 20752 64359236
Polyneuropathy 15.00 9.84 9 118735 19885 64360103
Carbohydrate antigen 125 increased 14.78 9.84 18 118726 1910 64378078
Post procedural complication 14.76 9.84 78 118666 21275 64358713
Rubber sensitivity 14.62 9.84 15 118729 1317 64378671
Multiple organ dysfunction syndrome 14.58 9.84 118 118626 101295 64278693
Toxic epidermal necrolysis 14.54 9.84 29 118715 37137 64342851
Chronic obstructive pulmonary disease 14.50 9.84 197 118547 70851 64309137
Thrombosis 14.47 9.84 196 118548 70446 64309542
Cardiac failure 14.38 9.84 165 118579 132208 64247780
Sleep apnoea syndrome 14.26 9.84 99 118645 29733 64350255
Duodenal stenosis 14.04 9.84 11 118733 677 64379311
Device expulsion 14.02 9.84 11 118733 21125 64358863
Ecchymosis 13.97 9.84 57 118687 13965 64366023
Pneumonitis 13.94 9.84 148 118596 50217 64329771
Poor sucking reflex 13.78 9.84 5 118739 60 64379928
Haemorrhage intracranial 13.71 9.84 83 118661 23801 64356187
Mobility decreased 13.70 9.84 97 118647 85743 64294245
Epistaxis 13.57 9.84 255 118489 97876 64282112
Rhabdomyolysis 13.52 9.84 106 118638 91620 64288368
Knee arthroplasty 13.43 9.84 18 118726 26981 64353007
Ileus 13.30 9.84 80 118664 22886 64357102
Heparin-induced thrombocytopenia 13.25 9.84 40 118704 8439 64371549
Abdominal discomfort 13.25 9.84 246 118498 182076 64197912
Infusion related reaction 13.20 9.84 218 118526 164249 64215739
Proctalgia 13.10 9.84 37 118707 7522 64372466
Urinary retention postoperative 13.02 9.84 6 118738 137 64379851
Upper respiratory tract infection 12.93 9.84 197 118547 72588 64307400
Rash 12.80 9.84 702 118042 457847 63922141
Non-small cell lung cancer 12.78 9.84 28 118716 4862 64375126
Grip strength decreased 12.67 9.84 3 118741 11721 64368267
Paratracheal lymphadenopathy 12.63 9.84 6 118738 147 64379841
Delirium 12.57 9.84 188 118556 69006 64310982
Noninfectious peritonitis 12.54 9.84 7 118737 242 64379746
Neuropathy peripheral 12.53 9.84 294 118450 117231 64262757
Depressed level of consciousness 12.53 9.84 93 118651 81343 64298645
Hypoacusis 12.46 9.84 86 118658 25781 64354207
Metabolic acidosis 12.42 9.84 78 118666 70880 64309108
Malignant neoplasm of thorax 12.30 9.84 3 118741 7 64379981
Muscle spasticity 12.29 9.84 62 118682 16607 64363381
Neurogenic bladder 12.16 9.84 23 118721 3596 64376392
Aortic aneurysm 12.09 9.84 36 118708 7538 64372450
Injection site rash 12.04 9.84 7 118737 15735 64364253
Spinal cord compression 12.00 9.84 30 118714 5673 64374315
Impaired healing 11.91 9.84 64 118680 60409 64319579
Posture abnormal 11.89 9.84 22 118722 3384 64376604
Oral pustule 11.82 9.84 7 118737 271 64379717
Circulatory collapse 11.80 9.84 28 118716 33704 64346284
Injection site warmth 11.78 9.84 5 118739 13457 64366531
Intestinal obstruction 11.67 9.84 110 118634 36176 64343812
Onychoclasis 11.67 9.84 26 118718 4566 64375422
Multiple sclerosis 11.63 9.84 67 118677 18874 64361114
Chills 11.61 9.84 333 118411 136931 64243057
Urinary retention 11.55 9.84 140 118604 49061 64330927
Prolapse 11.52 9.84 3 118741 10 64379978
Hepatitis 11.52 9.84 44 118700 45538 64334450
Purpura 11.41 9.84 9 118735 17237 64362751
Muscular weakness 11.35 9.84 311 118433 127027 64252961
Injection site bruising 11.34 9.84 32 118712 36341 64343647
Respiratory depression 11.29 9.84 16 118728 23427 64356561
Iron deficiency anaemia 11.28 9.84 74 118670 21815 64358173
Rectal haemorrhage 11.25 9.84 168 118576 61649 64318339
Abdominal mass 11.19 9.84 20 118724 2995 64376993
Oral candidiasis 11.08 9.84 77 118667 23135 64356853
Pathological fracture 10.94 9.84 39 118705 8966 64371022
Hospitalisation 10.94 9.84 197 118547 75010 64304978
Diabetes mellitus inadequate control 10.82 9.84 14 118730 21307 64358681
Disturbance in attention 10.80 9.84 39 118705 41035 64338953
Drug ineffective for unapproved indication 10.77 9.84 26 118718 31107 64348881
Posterior reversible encephalopathy syndrome 10.71 9.84 16 118728 22930 64357058
Sexually inappropriate behaviour 10.69 9.84 8 118736 460 64379528
Haemophagocytic lymphohistiocytosis 10.66 9.84 10 118734 17599 64362389
Bone erosion 10.65 9.84 4 118740 11591 64368397
Ageusia 10.63 9.84 52 118692 13761 64366227
Implant site erosion 10.51 9.84 5 118739 123 64379865
Emotional distress 10.49 9.84 107 118637 35931 64344057
Blood bilirubin decreased 10.43 9.84 10 118734 809 64379179
Seizure like phenomena 10.42 9.84 14 118730 1638 64378350
Eosinophil count decreased 10.37 9.84 18 118726 2634 64377354
Cerebrovascular accident 10.35 9.84 329 118415 137254 64242734
Inguinal hernia 10.35 9.84 28 118716 5553 64374435
Aspergillus infection 10.27 9.84 9 118735 16370 64363618
Psychomotor hyperactivity 10.26 9.84 7 118737 14444 64365544
Arteriovenous graft site infection 10.24 9.84 3 118741 17 64379971
Creatinine renal clearance decreased 10.22 9.84 7 118737 14414 64365574
Ill-defined disorder 10.20 9.84 44 118700 44008 64335980
Dry skin 10.09 9.84 141 118603 51020 64328968
Live birth 10.07 9.84 4 118740 11200 64368788
Hypertonia 10.04 9.84 30 118714 6295 64373693
Anaemia 9.98 9.84 818 117926 377862 64002126
Intentional product use issue 9.92 9.84 120 118624 95244 64284744

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
ATC A06AA02 ALIMENTARY TRACT AND METABOLISM
DRUGS FOR CONSTIPATION
DRUGS FOR CONSTIPATION
Softeners, emollients
ATC A06AG10 ALIMENTARY TRACT AND METABOLISM
DRUGS FOR CONSTIPATION
DRUGS FOR CONSTIPATION
Enemas
MeSH PA D013501 Surface-Active Agents

Drug Use (View source of the data)

DiseaseRelationSNOMED_IDDOID
Constipation indication 14760008 DOID:2089
Megaloblastic anemia due to folate deficiency indication 85649008 DOID:14026
Iron deficiency anemia indication 87522002
Pregnancy, function indication 289908002
Breastfeeding (mother) indication 413712001
Incomplete passage of stool off-label use 249515001
Prevention of Fetal Neural Tube Defects during Pregnancy off-label use
Peptic ulcer contraindication 13200003 DOID:750
Primary hyperoxaluria contraindication 17901006 DOID:2977
Gastroenteritis contraindication 25374005 DOID:2326
Hemosiderosis contraindication 39011001 DOID:12119
Hypokalemia contraindication 43339004
Bleeding hemorrhoids contraindication 51551000
Gastrectomy contraindication 53442002
Leber's optic atrophy contraindication 58610003 DOID:705
Hemolytic anemia contraindication 61261009 DOID:583
Ulcerative colitis contraindication 64766004 DOID:8577
Incontinence of feces contraindication 72042002
Appendicitis contraindication 74400008 DOID:8337
Atrophic gastritis contraindication 84568007 DOID:8929
Disorder of mucous membrane contraindication 95351003
Anemia due to enzyme deficiency contraindication 111577008
Gastrointestinal obstruction contraindication 126765001
Hb SS disease contraindication 127040003 DOID:10923
Urinary incontinence contraindication 165232002
Diverticular disease contraindication 397881000
Hemochromatosis contraindication 399187006 DOID:2352
Repeated Blood Transfusions contraindication




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 12.0 acidic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

None

External reference:

IDSource
4019731 VUID
N0000179792 NUI
D03885 KEGG_DRUG
128-49-4 SECONDARY_CAS_RN
71722 RXNORM
4017673 VANDF
4019248 VANDF
4019731 VANDF
C0243237 UMLSCUI
CHEBI:4674 CHEBI
CHEMBL1905872 ChEMBL_ID
CHEMBL1477036 ChEMBL_ID
CHEMBL2106608 ChEMBL_ID
531 INN_ID
F05Q2T2JA0 UNII
23673837 PUBCHEM_CID
DB11089 DRUGBANK_ID
29340 MMSL
4627 MMSL
4629 MMSL
6142 MMSL
6143 MMSL
NOCODE MMSL
d01021 MMSL
001180 NDDF
001181 NDDF
001183 NDDF
116528004 SNOMEDCT_US
387088007 SNOMEDCT_US
418528006 SNOMEDCT_US
418700002 SNOMEDCT_US
D004143 MESH_DESCRIPTOR_UI
577-11-7 SECONDARY_CAS_RN

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
good sense stool softener HUMAN OTC DRUG LABEL 1 0113-0486 CAPSULE, LIQUID FILLED 100 mg ORAL OTC monograph not final 15 sections
basic care stool softener HUMAN OTC DRUG LABEL 1 0113-7004 CAPSULE, LIQUID FILLED 100 mg ORAL OTC monograph not final 15 sections
Docusate Sodium HUMAN OTC DRUG LABEL 1 0121-0544 LIQUID 50 mg ORAL OTC monograph not final 15 sections
Docusate Sodium HUMAN OTC DRUG LABEL 1 0121-0935 LIQUID 50 mg ORAL OTC monograph not final 15 sections
Docusate Sodium HUMAN OTC DRUG LABEL 1 0121-1870 LIQUID 100 mg ORAL OTC monograph not final 15 sections
Pedia-Lax HUMAN OTC DRUG LABEL 1 0132-0106 LIQUID 50 mg ORAL OTC monograph not final 10 sections
Ferralet 90 HUMAN PRESCRIPTION DRUG LABEL 5 0178-0089 TABLET, FILM COATED 50 mg ORAL unapproved drug other 17 sections
CitraNatal Harmony 3.0 HUMAN PRESCRIPTION DRUG LABEL 8 0178-0796 CAPSULE, GELATIN COATED 50 mg ORAL unapproved drug other 10 sections
CitraNatal Harmony HUMAN PRESCRIPTION DRUG LABEL 8 0178-0798 CAPSULE, GELATIN COATED 50 mg ORAL UNAPPROVED DRUG OTHER 11 sections
CitraNatal Harmony HUMAN PRESCRIPTION DRUG LABEL 8 0178-0799 CAPSULE, GELATIN COATED 50 mg ORAL Unapproved drug other 11 sections
CitraNatal Harmony HUMAN PRESCRIPTION DRUG LABEL 8 0178-0812 CAPSULE, GELATIN COATED 50 mg ORAL Unapproved drug other 11 sections
CitraNatal Bloom HUMAN PRESCRIPTION DRUG LABEL 6 0178-0813 TABLET, FILM COATED 55 mg ORAL unapproved drug other 15 sections
CitraNatal 90 DHA HUMAN PRESCRIPTION DRUG LABEL 16 0178-0821 TABLET 50 mg ORAL unapproved drug other 11 sections
CitraNatal 90 DHA HUMAN OTC DRUG LABEL 14 0178-0829 TABLET 50 mg ORAL Unapproved drug other 11 sections
CitraNatal Rx HUMAN PRESCRIPTION DRUG LABEL 14 0178-0859 TABLET 50 mg ORAL Unapproved drug other 9 sections
CitraNatal DHA HUMAN OTC DRUG LABEL 14 0178-0898 TABLET 50 mg ORAL Unapproved drug other 11 sections
Phillips Stool SoftenerBulk Docusate HUMAN OTC DRUG LABEL 1 0280-1012 CAPSULE, LIQUID FILLED 100 mg ORAL OTC monograph not final 15 sections
Phillips Stool SoftenerBulk Docusate HUMAN OTC DRUG LABEL 1 0280-1012 CAPSULE, LIQUID FILLED 100 mg ORAL OTC monograph not final 15 sections
Stool Softener Laxative HUMAN OTC DRUG LABEL 1 0363-0016 CAPSULE, LIQUID FILLED 100 mg ORAL OTC MONOGRAPH NOT FINAL 14 sections
Stool Softener HUMAN OTC DRUG LABEL 1 0363-0257 CAPSULE, LIQUID FILLED 240 mg ORAL OTC monograph not final 14 sections
Stool SoftenerPlus Stimulant Laxative HUMAN OTC DRUG LABEL 2 0363-0584 TABLET 50 mg ORAL OTC MONOGRAPH NOT FINAL 14 sections
Gentle Stool Softener HUMAN OTC DRUG LABEL 1 0363-0655 CAPSULE, LIQUID FILLED 100 mg ORAL OTC monograph not final 14 sections
Stool Softener Laxative HUMAN OTC DRUG LABEL 1 0363-0679 CAPSULE, LIQUID FILLED 100 mg ORAL OTC MONOGRAPH NOT FINAL 14 sections
Senna S HUMAN OTC DRUG LABEL 2 0363-0785 TABLET 50 mg ORAL OTC MONOGRAPH NOT FINAL 14 sections
Stool Softener LaxativePlus Stimulant HUMAN OTC DRUG LABEL 2 0363-0827 TABLET 50 mg ORAL OTC MONOGRAPH NOT FINAL 14 sections
Stool Softener HUMAN OTC DRUG LABEL 1 0363-0868 CAPSULE, LIQUID FILLED 240 mg ORAL OTC monograph not final 14 sections
Senna S HUMAN OTC DRUG LABEL 2 0363-0883 TABLET 50 mg ORAL OTC monograph not final 14 sections
Stool Softener HUMAN OTC DRUG LABEL 1 0363-2570 CAPSULE, LIQUID FILLED 240 mg ORAL OTC MONOGRAPH NOT FINAL 14 sections
SENNA-S HUMAN OTC DRUG LABEL 2 0363-3010 CAPSULE, GELATIN COATED 50 mg ORAL OTC monograph not final 15 sections
Stool Softener Laxative HUMAN OTC DRUG LABEL 1 0363-4100 CAPSULE, LIQUID FILLED 100 mg ORAL OTC monograph not final 14 sections