All FDA-approved EMA-approved PMDA-approved
Target Card Uniprot Example: P23975

docusate sodium 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definition	Drug id	CAS RN
	941	10041-19-7

Description:

Molecule	Description
Molfile Inchi Smiles Synonyms: docusate dioctyl sulfosuccinate dioctyl sulfosuccinic acid docusate sodium docusate calcium dioctyl disodium sulfosuccinate	All-purpose surfactant, wetting agent, and solubilizer used in the drug, cosmetics, and food industries. It has also been used in laxatives and as cerumenolytics. It is usually administered as either the calcium, potassium, or sodium salt. Molecular weight: 422.58 Formula: C20H38O7S CLOGP: 5.46 LIPINSKI: 1 HAC: 7 HDO: 1 TPSA: 106.97 ALOGS: -5.02 ROTB: 18

Drug dosage:

Dose	Unit	Route
0.15	g	O

ADMET properties:

None

Approvals:

Date	Agency	Company	Orphan
None	FDA

FDA Adverse Event Reporting System (Female)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Drug ineffective	377.03	9.85	692	101191	1044073	62343066
Constipation	373.77	9.85	992	100891	223951	63163188
Systemic lupus erythematosus	271.08	9.85	16	101867	208902	63178237
Pemphigus	269.86	9.85	5	101878	183721	63203418
Synovitis	256.36	9.85	10	101873	186908	63200231
Hand deformity	231.52	9.85	5	101878	159452	63227687
Pneumonia aspiration	206.85	9.85	266	101617	34274	63352865
Glossodynia	178.71	9.85	35	101848	178841	63208298
Arthropathy	170.16	9.85	82	101801	234710	63152429
Maternal exposure during pregnancy	165.45	9.85	73	101810	219989	63167150
Therapeutic product effect decreased	163.72	9.85	53	101830	193134	63194005
Contraindicated product administered	159.26	9.85	75	101808	217573	63169566
Gastrooesophageal reflux disease	144.71	9.85	408	101475	95231	63291908
Discomfort	133.09	9.85	51	101832	167323	63219816
Duodenal ulcer perforation	125.51	9.85	3	101880	87206	63299933
Wound	121.35	9.85	55	101828	163208	63223931
Pericarditis	118.93	9.85	32	101851	131547	63255592
Completed suicide	116.46	9.85	44	101839	145629	63241510
Urinary tract infection	116.41	9.85	775	101108	263909	63123230
Drug intolerance	112.56	9.85	202	101681	308459	63078680
Joint swelling	109.42	9.85	226	101657	327440	63059699
Helicobacter infection	109.33	9.85	11	101872	92774	63294365
Swelling	107.02	9.85	173	101710	275205	63111934
Plasma cell myeloma	106.61	9.85	200	101683	35705	63351434
Pulmonary embolism	105.19	9.85	418	101465	116266	63270873
Treatment failure	98.94	9.85	104	101779	198939	63188200
Deep vein thrombosis	98.22	9.85	327	101556	83473	63303666
Alopecia	98.01	9.85	251	101632	337285	63049854
Mental status changes	91.80	9.85	199	101684	39400	63347739
Psoriatic arthropathy	91.16	9.85	18	101865	91502	63295637
Folliculitis	89.29	9.85	6	101877	70311	63316828
Back pain	84.18	9.85	717	101166	263428	63123711
Pulmonary malformation	82.30	9.85	27	101856	272	63386867
Death	79.01	9.85	933	100950	373448	63013691
Salpingo-oophorectomy unilateral	78.74	9.85	35	101848	846	63386293
Off label use	74.10	9.85	709	101174	673753	62713386
Abdominal discomfort	73.54	9.85	266	101617	320619	63066520
Pneumonia	73.35	9.85	1083	100800	455684	62931455
Sinusitis fungal	72.66	9.85	42	101841	1789	63385350
Coma	70.00	9.85	245	101638	64119	63323020
Dehydration	69.83	9.85	497	101386	172857	63214282
Sputum increased	68.48	9.85	45	101838	2414	63384725
Asthenia	68.15	9.85	926	100957	382678	63004461
Sleep disorder due to general medical condition, insomnia type	67.66	9.85	4	101879	52213	63334926
Anti-neutrophil cytoplasmic antibody positive vasculitis	66.36	9.85	47	101836	2852	63384287
Product use issue	66.27	9.85	161	101722	220359	63166780
Somnolence	66.10	9.85	502	101381	178183	63208956
Irritable bowel syndrome	65.66	9.85	25	101858	82387	63304752
Pleural effusion	64.89	9.85	309	101574	92901	63294238
Condition aggravated	63.95	9.85	381	101502	401836	62985303
Abdominal pain	63.47	9.85	735	101148	292721	63094418
Arthralgia	62.45	9.85	599	101284	569111	62818028
Hepatic enzyme increased	62.15	9.85	146	101737	202182	63184957
Embolism venous	60.59	9.85	46	101837	3108	63384031
Rheumatoid arthritis	59.72	9.85	208	101675	253611	63133528
Lung cyst	59.63	9.85	22	101861	322	63386817
C-reactive protein increased	57.32	9.85	41	101842	94666	63292473
General physical health deterioration	56.68	9.85	152	101731	201250	63185889
Liver injury	56.04	9.85	14	101869	60506	63326633
Therapeutic product effect incomplete	55.99	9.85	71	101812	124985	63262154
Hiatus hernia	55.25	9.85	113	101770	21481	63365658
Diverticulum	54.69	9.85	81	101802	11910	63375229
Respiratory symptom	53.92	9.85	44	101839	3303	63383836
Diastolic dysfunction	53.89	9.85	59	101824	6412	63380727
Intentional overdose	53.49	9.85	26	101857	74126	63313013
Toxicity to various agents	53.33	9.85	210	101673	247040	63140099
Oedema peripheral	52.91	9.85	500	101383	189011	63198128
Drug interaction	51.09	9.85	192	101691	228939	63158200
Hypoxia	50.50	9.85	210	101673	59582	63327557
Nausea	49.79	9.85	1754	100129	852717	62534422
Exposure during pregnancy	47.95	9.85	112	101771	155435	63231704
Respiratory tract malformation	47.43	9.85	16	101867	177	63386962
Full blood count decreased	47.40	9.85	119	101764	25905	63361234
Infection	46.69	9.85	199	101684	228974	63158165
Tricuspid valve incompetence	46.61	9.85	84	101799	14537	63372602
Small intestinal obstruction	45.79	9.85	95	101788	18242	63368897
Haemoglobin decreased	45.78	9.85	394	101489	145091	63242048
Intestinal pseudo-obstruction	44.60	9.85	24	101859	888	63386251
Temperature regulation disorder	44.42	9.85	52	101831	6080	63381059
Blister	43.70	9.85	89	101794	129725	63257414
Impaired healing	43.07	9.85	61	101822	102481	63284658
Fungal infection	42.39	9.85	143	101740	36731	63350408
Drug hypersensitivity	41.92	9.85	309	101574	310378	63076761
Fall	41.25	9.85	870	101013	391464	62995675
Hospice care	41.19	9.85	57	101826	7875	63379264
Disease progression	41.03	9.85	337	101546	122421	63264718
Cardiac failure congestive	40.13	9.85	270	101613	92163	63294976
Suicide attempt	40.08	9.85	24	101859	60894	63326245
Chest pain	39.36	9.85	524	101359	215435	63171704
Failure to thrive	39.31	9.85	53	101830	7145	63379994
Red blood cell sedimentation rate increased	39.15	9.85	11	101872	43971	63343168
White blood cell count decreased	37.80	9.85	365	101518	138739	63248400
Lethargy	37.76	9.85	184	101699	55823	63331316
Cestode infection	37.71	9.85	15	101868	272	63386867
Upper respiratory tract infection	36.42	9.85	241	101642	81806	63305333
Rash	36.22	9.85	658	101225	560213	62826926
Chronic sinusitis	36.21	9.85	70	101813	12773	63374366
Knee arthroplasty	36.16	9.85	21	101862	54185	63332954
Product use in unapproved indication	35.55	9.85	157	101726	178923	63208216
Nasal polyps	33.79	9.85	45	101838	5994	63381145
Drug abuse	33.68	9.85	40	101843	72478	63314661
Vomiting	33.00	9.85	1151	100732	558466	62828673
Emphysema	32.55	9.85	61	101822	10877	63376262
Febrile neutropenia	32.27	9.85	311	101572	118138	63269001
Infusion related reaction	32.24	9.85	246	101637	245275	63141864
Total lung capacity decreased	31.65	9.85	27	101856	2156	63384983
Peritonitis bacterial	31.46	9.85	39	101844	4840	63382299
Gastrointestinal disorder	31.20	9.85	107	101776	131132	63256007
Hip arthroplasty	31.02	9.85	19	101864	47627	63339512
Abortion spontaneous	30.48	9.85	19	101864	47176	63339963
Hip fracture	30.16	9.85	110	101773	29364	63357775
Magnesium deficiency	30.13	9.85	16	101867	576	63386563
Dyspnoea	30.03	9.85	1322	100561	659991	62727148
Hypervolaemia	29.89	9.85	107	101776	28306	63358833
Platelet count decreased	29.74	9.85	301	101582	115821	63271318
Cellulitis	28.46	9.85	227	101656	81731	63305408
Acute respiratory failure	28.24	9.85	120	101763	34365	63352774
Musculoskeletal stiffness	28.16	9.85	177	101706	184441	63202698
Fluid retention	28.13	9.85	178	101705	59508	63327631
Iron deficiency anaemia	28.05	9.85	83	101800	19886	63367253
Mobility decreased	27.98	9.85	100	101783	121059	63266080
Blood cholesterol increased	27.94	9.85	69	101814	93963	63293176
Injection site reaction	27.48	9.85	32	101851	58492	63328647
Female genital tract fistula	27.45	9.85	46	101837	7513	63379626
Premenstrual syndrome	27.23	9.85	16	101867	703	63386436
Food allergy	27.22	9.85	58	101825	11343	63375796
Device expulsion	27.14	9.85	11	101872	34911	63352228
Lactation disorder	27.06	9.85	13	101870	377	63386762
Hysterectomy	27.06	9.85	52	101831	9447	63377692
Exposure via breast milk	26.92	9.85	24	101859	2033	63385106
Bronchopulmonary aspergillosis allergic	26.91	9.85	25	101858	2233	63384906
Ill-defined disorder	26.71	9.85	57	101826	81698	63305441
Poor sucking reflex	26.62	9.85	12	101871	300	63386839
Lung opacity	26.58	9.85	29	101854	3139	63384000
Drug resistance	26.29	9.85	3	101880	22930	63364209
Blood potassium decreased	26.16	9.85	135	101748	41891	63345248
Atrial fibrillation	25.99	9.85	294	101589	116342	63270797
Neutrophil count decreased	25.83	9.85	167	101716	56239	63330900
Autonomic dysreflexia	25.77	9.85	12	101871	324	63386815
Live birth	25.60	9.85	5	101878	25625	63361514
Lip pruritus	25.57	9.85	17	101866	930	63386209
Hypersensitivity	25.48	9.85	324	101559	292361	63094778
International normalised ratio increased	25.42	9.85	144	101739	46281	63340858
Abdominal distension	25.38	9.85	231	101652	86384	63300755
Excessive eye blinking	25.32	9.85	19	101864	1261	63385878
Anaemia	25.00	9.85	632	101251	292798	63094341
Interstitial lung disease	24.85	9.85	38	101845	61870	63325269
Injection site erythema	24.73	9.85	61	101822	83113	63304026
Hyponatraemia	24.45	9.85	281	101602	111619	63275520
Maternal exposure during breast feeding	24.34	9.85	32	101851	4209	63382930
Blood calcium increased	24.00	9.85	49	101834	9301	63377838
Type 2 diabetes mellitus	23.95	9.85	41	101842	63827	63323312
Polymenorrhoea	23.88	9.85	18	101865	1203	63385936
Unresponsive to stimuli	23.44	9.85	112	101771	33704	63353435
Lichen sclerosus	23.15	9.85	17	101866	1092	63386047
Intentional product use issue	23.09	9.85	116	101767	127776	63259363
Injection site pruritus	23.04	9.85	23	101860	45093	63342046
Sleep apnoea syndrome	22.80	9.85	100	101783	29033	63358106
Dental restoration failure	22.59	9.85	16	101867	971	63386168
Gastrointestinal haemorrhage	22.53	9.85	214	101669	80962	63306177
Carbohydrate antigen 125 increased	22.29	9.85	25	101858	2791	63384348
Obstructive airways disorder	21.81	9.85	78	101805	20621	63366518
Therapy non-responder	21.54	9.85	57	101826	75844	63311295
Granulocytopenia	21.25	9.85	35	101848	5637	63381502
Aspiration	21.22	9.85	51	101832	10800	63376339
Neuropathy peripheral	21.18	9.85	277	101606	113390	63273749
Accidental exposure to product	20.71	9.85	9	101874	27396	63359743
Fatigue	20.56	9.85	1672	100211	886356	62500783
Hyperaesthesia	20.52	9.85	46	101837	9312	63377827
Chronic obstructive pulmonary disease	20.35	9.85	171	101712	62515	63324624
Immunodeficiency	20.22	9.85	75	101808	20179	63366960
Injection site pain	19.50	9.85	125	101758	129675	63257464
Respiratory failure	19.30	9.85	249	101634	101609	63285530
Hypophagia	19.17	9.85	100	101783	31159	63355980
Thrombosis	19.12	9.85	173	101710	64582	63322557
Grip strength decreased	19.06	9.85	6	101877	22281	63364858
Adverse event	18.97	9.85	51	101832	67508	63319631
Hypotension	18.93	9.85	572	101311	272032	63115107
Inflammation	18.93	9.85	68	101815	82205	63304934
Drug-induced liver injury	18.88	9.85	22	101861	40200	63346939
Premature baby	18.80	9.85	5	101878	20730	63366409
Cytokine release syndrome	18.70	9.85	58	101825	14256	63372883
Sepsis	18.53	9.85	347	101536	152776	63234363
Menstruation delayed	18.43	9.85	18	101865	1711	63385428
Injection site swelling	18.33	9.85	30	101853	47542	63339597
Haematocrit decreased	18.33	9.85	117	101766	39223	63347916
Dysphagia	18.26	9.85	220	101663	88365	63298774
Rheumatoid nodule	17.88	9.85	3	101880	17152	63369987
Emotional distress	17.85	9.85	101	101782	32448	63354691
Coeliac disease	17.79	9.85	53	101830	12744	63374395
Drug reaction with eosinophilia and systemic symptoms	17.56	9.85	17	101866	33819	63353320
Uterine perforation	17.30	9.85	36	101847	6927	63380212
Noninfectious peritonitis	17.20	9.85	7	101876	135	63387004
Urticaria	16.96	9.85	177	101706	165625	63221514
Dysmetropsia	16.91	9.85	6	101877	78	63387061
Onychoclasis	16.44	9.85	33	101850	6189	63380950
Lower gastrointestinal haemorrhage	16.43	9.85	38	101845	7852	63379287
Decreased appetite	16.43	9.85	523	101360	250529	63136610
Presyncope	16.43	9.85	88	101795	27697	63359442
Myelosuppression	16.07	9.85	9	101874	23694	63363445
Epistaxis	16.05	9.85	183	101700	72542	63314597
Flatulence	16.04	9.85	103	101780	34599	63352540
Loss of personal independence in daily activities	16.02	9.85	91	101792	97199	63289940
Body temperature fluctuation	15.93	9.85	19	101864	2266	63384873
Oesophageal ulcer	15.88	9.85	27	101856	4463	63382676
Tremor	15.77	9.85	299	101584	131940	63255199
Intestinal obstruction	15.72	9.85	94	101789	30805	63356334
Multiple sclerosis	15.66	9.85	79	101804	24293	63362846
Drug ineffective for unapproved indication	15.59	9.85	19	101864	34044	63353095
Candida infection	15.56	9.85	88	101795	28263	63358876
Lip dry	15.49	9.85	3	101880	15467	63371672
Pregnancy	15.37	9.85	22	101861	36814	63350325
Duodenal stenosis	15.29	9.85	10	101873	532	63386607
Anxiety	15.24	9.85	457	101426	217084	63170055
Proteinuria	15.20	9.85	66	101817	19079	63368060
Fibromyalgia	15.05	9.85	72	101811	80348	63306791
Electrocardiogram PR prolongation	14.89	9.85	11	101872	713	63386426
Cholelithiasis	14.88	9.85	121	101762	43804	63343335
Atelectasis	14.78	9.85	71	101812	21412	63365727
Palmoplantar keratoderma	14.50	9.85	17	101866	1990	63385149
Nasal discharge discolouration	14.40	9.85	18	101865	2253	63384886
Medication error	14.28	9.85	40	101843	52244	63334895
Stomatitis	14.23	9.85	148	101735	138577	63248562
Heart rate increased	14.09	9.85	221	101662	94017	63293122
Decubitus ulcer	14.09	9.85	43	101840	10477	63376662
Joint range of motion decreased	13.90	9.85	19	101864	32409	63354730
Dyspnoea exertional	13.88	9.85	153	101730	60149	63326990
Blood bilirubin decreased	13.85	9.85	11	101872	794	63386345
Cerebrovascular accident	13.83	9.85	247	101636	107777	63279362
Red blood cell count decreased	13.79	9.85	112	101771	40533	63346606
Carotid artery occlusion	13.74	9.85	26	101857	4668	63382471
Anaphylactic reaction	13.68	9.85	57	101826	66043	63321096
Cholecystitis chronic	13.55	9.85	42	101841	10319	63376820
Cardiospasm	13.53	9.85	16	101867	1891	63385248
Urinary retention postoperative	13.50	9.85	5	101878	74	63387065
Anaphylactic shock	13.31	9.85	11	101872	23622	63363517
Blood loss anaemia	13.20	9.85	38	101845	8963	63378176
Injection site warmth	13.16	9.85	4	101879	15191	63371948
Drug eruption	13.14	9.85	16	101867	28678	63358461
Bone erosion	13.10	9.85	6	101877	17711	63369428
Sinus bradycardia	12.99	9.85	52	101831	14499	63372640
Foetal exposure timing unspecified	12.91	9.85	7	101876	263	63386876
Impaired work ability	12.79	9.85	6	101877	17469	63369670
Rash erythematous	12.77	9.85	114	101769	42396	63344743
Liver disorder	12.60	9.85	44	101839	53643	63333496
Epiglottic oedema	12.50	9.85	5	101878	92	63387047
Balance disorder	12.25	9.85	197	101686	84225	63302914
Pruritus genital	12.20	9.85	18	101865	2636	63384503
Gastrointestinal arteriovenous malformation	12.19	9.85	9	101874	583	63386556
Epiglottic erythema	12.13	9.85	4	101879	41	63387098
Intentional self-injury	12.11	9.85	14	101869	25673	63361466
Sleep terror	12.07	9.85	18	101865	2662	63384477
Malignant neoplasm of thorax	11.93	9.85	3	101880	10	63387129
Non-small cell lung cancer	11.90	9.85	21	101862	3574	63383565
Laboratory test abnormal	11.90	9.85	79	101804	26833	63360306
Pulmonary hypertension	11.90	9.85	101	101782	37022	63350117
Rales	11.84	9.85	46	101837	12651	63374488
Transfusion	11.73	9.85	52	101831	15165	63371974
Rhabdomyolysis	11.73	9.85	34	101849	43917	63343222
Calculus bladder	11.73	9.85	9	101874	618	63386521
Injection site rash	11.56	9.85	8	101875	18801	63368338
Weight decreased	11.55	9.85	549	101334	276249	63110890
Arteriovenous graft site infection	11.50	9.85	3	101880	12	63387127
Epilepsy	11.46	9.85	16	101867	27049	63360090
Cardiac murmur	11.42	9.85	50	101833	14502	63372637
Pneumonitis	11.38	9.85	96	101787	35126	63352013
Catheter site bruise	11.33	9.85	8	101875	483	63386656
Asthma	11.21	9.85	276	101607	127285	63259854
Pneumonia viral	11.19	9.85	33	101850	7889	63379250
Immune-mediated encephalitis	11.00	9.85	6	101877	228	63386911
Rubber sensitivity	11.00	9.85	16	101867	2315	63384824
Arthritis	10.95	9.85	126	101757	115795	63271344
Premature delivery	10.84	9.85	20	101863	30261	63356878
Burkholderia test positive	10.75	9.85	6	101877	239	63386900
Urinary incontinence	10.74	9.85	88	101795	31926	63355213
Abdominal mass	10.69	9.85	18	101865	2952	63384187
Rectal haemorrhage	10.65	9.85	123	101760	48907	63338232
Gingival pain	10.59	9.85	33	101850	8129	63379010
Urinary tract infection enterococcal	10.51	9.85	17	101866	2696	63384443
Mean platelet volume increased	10.47	9.85	8	101875	546	63386593
Faeces hard	10.46	9.85	15	101868	2142	63384997
Enterocele	10.40	9.85	4	101879	66	63387073
Haemorrhoids	10.39	9.85	66	101817	22084	63365055
Foot deformity	10.33	9.85	18	101865	27835	63359304
Hyperhidrosis	10.29	9.85	236	101647	107600	63279539
Ecchymosis	10.19	9.85	40	101843	11054	63376085
Use of accessory respiratory muscles	10.18	9.85	6	101877	265	63386874
Diarrhoea	10.15	9.85	1303	100580	714063	62673076
Sleep disorder	10.09	9.85	83	101800	81483	63305656
Lupus-like syndrome	10.09	9.85	6	101877	15289	63371850
Catheter site pain	10.07	9.85	23	101860	4712	63382427
Wrong product administered	10.07	9.85	27	101856	6114	63381025
Abdominal pain upper	10.05	9.85	416	101467	206028	63181111
Musculoskeletal chest pain	10.00	9.85	63	101820	21020	63366119
Hallucination	9.96	9.85	133	101750	54684	63332455
Embolic stroke	9.94	9.85	20	101863	3756	63383383
Peritonitis	9.92	9.85	54	101829	17100	63370039

FDA Adverse Event Reporting System (Male)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Constipation	202.25	10.50	652	66779	136330	34753170
Drug ineffective	198.19	10.50	363	67068	456388	34433112
Completed suicide	118.08	10.50	23	67408	98145	34791355
Drug abuse	107.66	10.50	29	67402	99067	34790433
Plasma cell myeloma	96.32	10.50	235	67196	41802	34847698
Off label use	84.18	10.50	471	66960	419053	34470447
Urinary tract infection	68.96	10.50	333	67098	83748	34805752
Mental status changes	66.99	10.50	193	67238	37890	34851610
Pneumonia	60.50	10.50	1008	66423	361619	34527881
Death	55.29	10.50	1075	66356	396974	34492526
Toxicity to various agents	52.39	10.50	204	67227	200158	34689342
Fatigue	49.07	10.50	994	66437	369659	34519841
Intentional overdose	46.99	10.50	13	67418	43661	34845839
Fall	45.94	10.50	595	66836	202290	34687210
Febrile neutropenia	43.50	10.50	429	67002	136420	34753080
Failure to thrive	43.13	10.50	67	67364	8534	34880966
Confusional state	39.72	10.50	439	66992	143721	34745779
Burkholderia test positive	37.94	10.50	24	67407	999	34888501
Dehydration	36.81	10.50	398	67033	129571	34759929
Hepatic function abnormal	36.53	10.50	20	67411	44343	34845157
Drug interaction	36.28	10.50	271	67160	225675	34663825
Product use in unapproved indication	35.80	10.50	112	67319	117387	34772113
Hypersomnia	35.77	10.50	76	67355	12331	34877169
C-reactive protein increased	35.77	10.50	31	67400	54067	34835433
Failure to suspend medication	34.88	10.50	17	67414	421	34889079
Drug resistance	33.51	10.50	5	67426	25922	34863578
Hallucination	33.27	10.50	191	67240	51307	34838193
Treatment failure	33.06	10.50	25	67406	46672	34842828
Asthenia	32.44	10.50	658	66773	244593	34644907
Hospice care	31.96	10.50	52	67379	6888	34882612
Interstitial lung disease	31.68	10.50	48	67383	65234	34824266
Accident	30.62	10.50	43	67388	5004	34884496
Anal inflammation	30.48	10.50	23	67408	1277	34888223
Vomiting	30.34	10.50	657	66774	246964	34642536
Hypoxia	30.30	10.50	196	67235	54899	34834601
Walking aid user	30.30	10.50	27	67404	1897	34887603
Painful respiration	29.28	10.50	22	67409	1214	34888286
Full blood count decreased	29.25	10.50	89	67342	17999	34871501
Cholestasis	29.03	10.50	8	67423	26940	34862560
Therapeutic product effect incomplete	28.78	10.50	33	67398	50508	34838992
Accidental death	28.28	10.50	29	67402	2427	34887073
Coma	28.04	10.50	28	67403	45650	34843850
Back pain	27.43	10.50	357	67074	121432	34768068
Sepsis	26.16	10.50	459	66972	166102	34723398
Renal impairment	26.10	10.50	94	67337	94419	34795081
SARS-CoV-2 test negative	26.06	10.50	19	67412	1001	34888499
Proctalgia	25.17	10.50	42	67389	5681	34883819
Hepatocellular injury	25.06	10.50	6	67425	22205	34867295
Small intestinal obstruction	24.84	10.50	74	67357	14792	34874708
Granulocytopenia	24.72	10.50	45	67386	6522	34882978
Unresponsive to stimuli	24.63	10.50	112	67319	27457	34862043
Chest injury	24.41	10.50	22	67409	1569	34887931
Drug reaction with eosinophilia and systemic symptoms	24.24	10.50	17	67414	32995	34856505
Deep vein thrombosis	23.93	10.50	211	67220	65037	34824463
Peripheral artery thrombosis	23.86	10.50	26	67405	2334	34887166
Rheumatoid arthritis	22.83	10.50	24	67407	38214	34851286
Intestinal pseudo-obstruction	22.55	10.50	22	67409	1734	34887766
Hyponatraemia	21.91	10.50	250	67181	82441	34807059
Peripheral swelling	21.46	10.50	234	67197	76307	34813193
Condition aggravated	21.17	10.50	253	67178	191943	34697557
Pleural effusion	20.92	10.50	245	67186	81301	34808199
Abdominal distension	20.86	10.50	188	67243	58304	34831196
Overdose	20.51	10.50	98	67333	90961	34798539
Foetal exposure during pregnancy	20.50	10.50	26	67405	38075	34851425
White blood cell count decreased	20.32	10.50	277	67154	95168	34794332
Myelosuppression	20.23	10.50	6	67425	19259	34870241
Suicide attempt	19.71	10.50	28	67403	39088	34850412
Gangrene neonatal	19.69	10.50	9	67422	192	34889308
Spinal fracture	19.42	10.50	44	67387	7454	34882046
Skin turgor decreased	19.42	10.50	12	67419	479	34889021
Muscle spasticity	19.26	10.50	38	67393	5850	34883650
Premature baby	19.06	10.50	7	67424	19626	34869874
Paraneoplastic rash	18.76	10.50	7	67424	87	34889413
Decubitus ulcer	18.45	10.50	48	67383	8873	34880627
Metabolic encephalopathy	18.21	10.50	31	67400	4261	34885239
Pathological fracture	17.70	10.50	31	67400	4360	34885140
Haemorrhoids	17.60	10.50	65	67366	14510	34874990
Eosinophilia	17.36	10.50	15	67416	26207	34863293
Epilepsy	17.25	10.50	10	67421	21485	34868015
Pulmonary vasculitis	17.24	10.50	12	67419	587	34888913
Hypotension	17.21	10.50	554	66877	221095	34668405
Myasthenia gravis	17.18	10.50	40	67391	6900	34882600
Peritonitis bacterial	17.12	10.50	37	67394	6073	34883427
Hypoacusis	16.68	10.50	69	67362	16232	34873268
Anaphylactic shock	16.67	10.50	5	67426	15936	34873564
Neuropathy peripheral	16.65	10.50	239	67192	83024	34806476
Nausea	16.64	10.50	808	66623	339100	34550400
Neuritis	16.51	10.50	14	67417	920	34888580
Moaning	16.45	10.50	13	67418	773	34888727
Thrombosis	16.39	10.50	159	67272	50299	34839201
Hyporesponsive to stimuli	16.37	10.50	15	67416	1093	34888407
Metastatic renal cell carcinoma	16.29	10.50	20	67411	2041	34887459
Haematocrit decreased	16.14	10.50	112	67319	32104	34857396
Ageusia	16.00	10.50	50	67381	10258	34879242
Cellulitis	15.83	10.50	164	67267	52787	34836713
Gamma-glutamyltransferase increased	15.67	10.50	20	67411	29211	34860289
Inflammation	15.54	10.50	19	67412	28276	34861224
Urosepsis	15.39	10.50	57	67374	12742	34876758
Pleurothotonus	15.29	10.50	15	67416	1190	34888310
Oral pustule	14.92	10.50	8	67423	243	34889257
Disease progression	14.57	10.50	291	67140	107786	34781714
Appendicolith	14.55	10.50	43	67388	8558	34880942
Pulmonary embolism	14.31	10.50	248	67183	89498	34800002
Abdominal pain	14.30	10.50	415	67016	163203	34726297
Paratracheal lymphadenopathy	14.06	10.50	6	67425	108	34889392
Dry mouth	14.02	10.50	103	67328	30062	34859438
Cytomegalovirus infection	13.88	10.50	18	67413	26117	34863383
Metabolic acidosis	13.74	10.50	41	67390	43639	34845861
Synovitis	13.68	10.50	5	67426	14061	34875439
Dysphagia	13.66	10.50	182	67249	62199	34827301
Toxic epidermal necrolysis	13.59	10.50	13	67418	21633	34867867
Sitting disability	13.54	10.50	7	67424	197	34889303
Injection site pain	13.47	10.50	35	67396	38970	34850530
Accidental exposure to product	13.42	10.50	4	67427	12798	34876702
Hypervolaemia	13.31	10.50	74	67357	19635	34869865
Rib fracture	13.23	10.50	59	67372	14341	34875159
Intentional self-injury	13.22	10.50	5	67426	13766	34875734
Urinary retention	13.12	10.50	117	67314	36171	34853329
Product use issue	13.11	10.50	70	67361	63146	34826354
Eczema	12.88	10.50	10	67421	18426	34871074
Urinary incontinence	12.84	10.50	71	67360	18803	34870697
Weight decrease neonatal	12.69	10.50	8	67423	331	34889169
Wrong technique in product usage process	12.65	10.50	32	67399	35954	34853546
Myotonic dystrophy	12.52	10.50	6	67425	143	34889357
Maternal exposure during breast feeding	12.25	10.50	15	67416	1526	34887974
Contraindicated product administered	12.25	10.50	14	67417	21467	34868033
Cardiac failure congestive	12.17	10.50	227	67204	83043	34806457
Stress	12.10	10.50	100	67331	30247	34859253
Injection site reaction	12.07	10.50	5	67426	13028	34876472
Pain	12.06	10.50	496	66935	204179	34685321
Therapeutic response decreased	11.99	10.50	24	67407	29289	34860211
Product prescribing error	11.96	10.50	16	67415	22911	34866589
Neurogenic bladder	11.83	10.50	16	67415	1797	34887703
Body height decreased	11.61	10.50	24	67407	3819	34885681
Blood phosphorus increased	11.57	10.50	37	67394	7684	34881816
Muscle spasms	11.50	10.50	206	67225	74795	34814705
Muscular weakness	11.46	10.50	201	67230	72696	34816804
Incorrect dose administered	11.37	10.50	40	67391	40475	34849025
Blood potassium decreased	11.27	10.50	66	67365	17849	34871651
Oral pain	11.21	10.50	46	67385	10781	34878719
Decreased appetite	11.16	10.50	409	67022	165983	34723517
Bone marrow failure	11.08	10.50	25	67406	29228	34860272
Wrong patient received product	11.04	10.50	19	67412	2635	34886865
Band neutrophil percentage increased	10.97	10.50	5	67426	106	34889394
Dry skin	10.86	10.50	100	67331	31187	34858313
Chills	10.85	10.50	218	67213	80825	34808675
General physical health deterioration	10.84	10.50	178	67253	128091	34761409
Acute hepatic failure	10.66	10.50	7	67424	14067	34875433
Aortic aneurysm	10.63	10.50	33	67398	6746	34882754
Seizure like phenomena	10.62	10.50	10	67421	754	34888746
Drug therapy	10.55	10.50	12	67419	1129	34888371
Polyneuropathy	10.51	10.50	8	67423	14888	34874612

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Drug ineffective	384.64	9.52	795	135300	1080118	78528175
Constipation	384.22	9.52	1208	134887	281842	79326451
Completed suicide	233.70	9.52	65	136030	245702	79362591
Synovitis	215.00	9.52	10	136085	150724	79457569
Systemic lupus erythematosus	160.74	9.52	12	136083	121137	79487156
Hand deformity	154.62	9.52	5	136090	103914	79504379
Plasma cell myeloma	150.48	9.52	301	135794	52958	79555335
Pemphigus	143.99	9.52	6	136089	99576	79508717
Urinary tract infection	138.22	9.52	871	135224	273641	79334652
Mental status changes	137.61	9.52	333	135762	66626	79541667
Toxicity to various agents	129.69	9.52	334	135761	421206	79187087
Drug abuse	125.91	9.52	60	136035	162631	79445662
Off label use	125.48	9.52	971	135124	906244	78702049
Death	124.03	9.52	1494	134601	565020	79043273
Therapeutic product effect decreased	122.93	9.52	63	136032	163800	79444493
Pneumonia aspiration	121.86	9.52	318	135777	66649	79541644
Gastrooesophageal reflux disease	116.32	9.52	417	135678	103829	79504464
Arthropathy	108.34	9.52	86	136009	177025	79431268
Pulmonary embolism	106.00	9.52	575	135520	171079	79437214
Deep vein thrombosis	101.22	9.52	442	135653	120477	79487816
Pneumonia	97.31	9.52	1624	134471	658622	78949671
Duodenal ulcer perforation	92.45	9.52	5	136090	66206	79542087
Maternal exposure during pregnancy	91.72	9.52	60	136035	136478	79471815
Febrile neutropenia	91.35	9.52	691	135404	230308	79377985
Contraindicated product administered	90.81	9.52	81	136014	157457	79450836
Discomfort	90.25	9.52	51	136044	125566	79482727
Intentional overdose	88.44	9.52	35	136060	105925	79502368
Pericarditis	84.45	9.52	36	136059	104200	79504093
Treatment failure	83.23	9.52	101	135994	170385	79437908
Glossodynia	83.23	9.52	36	136059	103301	79504992
Failure to thrive	81.72	9.52	101	135994	11743	79596550
Hypoxia	80.10	9.52	369	135726	102874	79505419
Helicobacter infection	79.48	9.52	12	136083	69692	79538601
Joint swelling	78.84	9.52	242	135853	288404	79319889
C-reactive protein increased	78.46	9.52	63	136032	128964	79479329
Back pain	76.64	9.52	825	135270	303355	79304938
Salpingo-oophorectomy unilateral	72.16	9.52	33	136062	801	79607492
Drug intolerance	68.91	9.52	226	135869	263893	79344400
Folliculitis	66.79	9.52	8	136087	55372	79552921
Dehydration	66.66	9.52	682	135413	247505	79360788
Psoriatic arthropathy	66.35	9.52	25	136070	77974	79530319
Intestinal pseudo-obstruction	65.88	9.52	46	136049	2563	79605730
Condition aggravated	64.57	9.52	546	135549	500578	79107715
Muscle injury	63.86	9.52	5	136090	48556	79559737
Pleural effusion	62.80	9.52	444	135651	144818	79463475
Pulmonary malformation	62.70	9.52	21	136074	212	79608081
Drug interaction	62.59	9.52	433	135662	414750	79193543
Small intestinal obstruction	61.86	9.52	141	135954	27131	79581162
Asthenia	59.96	9.52	1215	134880	510474	79097819
Sleep disorder due to general medical condition, insomnia type	58.66	9.52	4	136091	43552	79564741
Respiratory symptom	56.12	9.52	54	136041	4737	79603556
Abdominal pain	55.65	9.52	954	135141	388615	79219678
Sinusitis fungal	55.65	9.52	40	136055	2334	79605959
Product use in unapproved indication	54.97	9.52	230	135865	250129	79358164
Hepatocellular injury	54.70	9.52	8	136087	47585	79560708
Therapeutic product effect incomplete	54.43	9.52	99	135996	141546	79466747
Fall	54.21	9.52	1149	134946	486480	79121813
Suicide attempt	53.61	9.52	38	136057	82894	79525399
Granulocytopenia	52.42	9.52	80	136015	11351	79596942
Alopecia	51.75	9.52	211	135884	231144	79377149
Irritable bowel syndrome	51.21	9.52	21	136074	62220	79546073
Drug resistance	51.15	9.52	6	136089	42207	79566086
Sepsis	50.88	9.52	692	135403	268736	79339557
Fatigue	48.92	9.52	1994	134101	927733	78680560
Vomiting	48.91	9.52	1484	134611	664344	78943949
Rheumatoid arthritis	48.61	9.52	187	135908	208283	79400010
Lung cyst	48.36	9.52	19	136076	312	79607981
Hospice care	46.98	9.52	72	136023	10252	79598041
Interstitial lung disease	46.65	9.52	75	136020	112525	79495768
Wound	46.63	9.52	79	136016	116100	79492193
General physical health deterioration	46.57	9.52	277	135818	274961	79333332
Peritonitis bacterial	45.35	9.52	68	136027	9499	79598794
Nausea	45.20	9.52	2030	134065	955166	78653127
Unresponsive to stimuli	45.19	9.52	202	135893	55586	79552707
Arthralgia	44.92	9.52	696	135399	571107	79037186
Hiatus hernia	44.77	9.52	113	135982	23199	79585094
Anti-neutrophil cytoplasmic antibody positive vasculitis	43.62	9.52	42	136053	3687	79604606
Myelosuppression	43.57	9.52	8	136087	40288	79568005
Hepatic enzyme increased	43.09	9.52	163	135932	182447	79425846
Sputum increased	43.08	9.52	46	136049	4567	79603726
Haemoglobin decreased	42.95	9.52	573	135522	221546	79386747
Oedema peripheral	42.82	9.52	636	135459	251652	79356641
Embolism venous	42.67	9.52	44	136051	4195	79604098
Disease progression	42.26	9.52	491	135604	183871	79424422
Hyponatraemia	41.81	9.52	476	135619	177372	79430921
Infection	41.56	9.52	242	135853	241470	79366823
Product use issue	40.53	9.52	202	135893	209620	79398673
Dyspnoea	40.52	9.52	1818	134277	855207	78753086
Hypersomnia	40.32	9.52	108	135987	22978	79585315
White blood cell count decreased	39.46	9.52	493	135602	187795	79420498
Diverticulum	38.30	9.52	81	136014	14815	79593478
Abdominal distension	38.13	9.52	341	135754	119309	79488984
Cellulitis	37.98	9.52	317	135778	108743	79499550
Diastolic dysfunction	37.86	9.52	67	136028	10744	79597549
Cestode infection	37.28	9.52	15	136080	263	79608030
Respiratory tract malformation	36.76	9.52	12	136083	111	79608182
Lethargy	36.60	9.52	251	135844	81041	79527252
Drug reaction with eosinophilia and systemic symptoms	35.85	9.52	34	136061	64210	79544083
Full blood count decreased	35.82	9.52	114	135981	26705	79581588
Temperature regulation disorder	35.78	9.52	47	136048	5806	79602487
Poor sucking reflex	35.67	9.52	12	136083	123	79608170
Hypervolaemia	35.66	9.52	156	135939	42534	79565759
Injection site reaction	35.54	9.52	25	136070	54760	79553533
Autonomic dysreflexia	33.42	9.52	16	136079	432	79607861
Somnolence	33.26	9.52	583	135512	238398	79369895
Inflammation	33.00	9.52	69	136026	93684	79514609
Exposure during pregnancy	32.68	9.52	78	136017	101054	79507239
Failure to suspend medication	32.56	9.52	16	136079	458	79607835
Proctalgia	32.50	9.52	60	136035	9941	79598352
Red blood cell sedimentation rate increased	32.49	9.52	19	136076	45923	79562370
Acute respiratory failure	32.46	9.52	193	135902	59348	79548945
Upper respiratory tract infection	32.28	9.52	266	135829	90902	79517391
Cholestasis	32.22	9.52	25	136070	52084	79556209
Liver injury	31.55	9.52	30	136065	56584	79551709
Impaired healing	31.28	9.52	64	136031	87591	79520702
Hypotension	31.08	9.52	977	135118	439340	79168953
Neutrophil count decreased	31.08	9.52	270	135825	93689	79514604
Haematocrit decreased	30.43	9.52	194	135901	61118	79547175
Swelling	30.19	9.52	231	135864	216480	79391813
Gastrointestinal disorder	30.19	9.52	107	135988	122098	79486195
Premenstrual syndrome	29.88	9.52	16	136079	550	79607743
Drug hypersensitivity	29.52	9.52	347	135748	298569	79309724
Female genital tract fistula	29.08	9.52	43	136052	5932	79602361
Total lung capacity decreased	28.97	9.52	30	136065	2875	79605418
Injection site erythema	28.85	9.52	56	136039	78141	79530152
Blood potassium decreased	28.80	9.52	156	135939	46356	79561937
Chest pain	28.69	9.52	657	135438	281647	79326646
Injection site pain	28.64	9.52	119	135976	129719	79478574
Fungal infection	28.59	9.52	144	135951	41604	79566689
Tricuspid valve incompetence	28.37	9.52	86	136009	19626	79588667
Emphysema	28.21	9.52	76	136019	16224	79592069
Maternal exposure during breast feeding	28.20	9.52	29	136066	2756	79605537
Confusional state	28.08	9.52	726	135369	317271	79291022
Fluid retention	27.64	9.52	209	135886	69600	79538693
Drug ineffective for unapproved indication	27.57	9.52	28	136067	51210	79557083
Abdominal discomfort	27.56	9.52	284	135811	250443	79357850
Hepatic function abnormal	27.28	9.52	52	136043	73055	79535238
Chronic sinusitis	26.98	9.52	65	136030	12961	79595332
Urticaria	26.95	9.52	195	135900	185006	79423287
Burkholderia test positive	26.64	9.52	15	136080	570	79607723
Anal inflammation	26.64	9.52	21	136074	1409	79606884
Cardiac failure congestive	26.54	9.52	365	135730	142037	79466256
Knee arthroplasty	26.42	9.52	21	136074	43227	79565066
Therapeutic response decreased	26.33	9.52	46	136049	66807	79541486
Hip fracture	26.14	9.52	113	135982	30648	79577645
Polymenorrhoea	26.08	9.52	18	136077	984	79607309
Decubitus ulcer	26.01	9.52	72	136023	15615	79592678
Magnesium deficiency	25.74	9.52	15	136080	609	79607684
Dysphagia	25.66	9.52	320	135775	121816	79486477
Blister	25.43	9.52	111	135984	119365	79488928
Lactation disorder	25.34	9.52	11	136084	235	79608058
Hysterectomy	24.77	9.52	41	136054	6231	79602062
Hallucination	24.61	9.52	239	135856	85506	79522787
Food allergy	24.59	9.52	56	136039	10768	79597525
Grip strength decreased	24.39	9.52	4	136091	21865	79586428
Bronchopulmonary aspergillosis allergic	24.24	9.52	28	136067	3033	79605260
Hypophagia	24.05	9.52	146	135949	45221	79563072
Haemorrhoids	23.99	9.52	106	135989	29022	79579271
Injection site swelling	23.97	9.52	27	136068	47105	79561188
Anaphylactic shock	23.91	9.52	16	136079	35980	79572313
Lichen sclerosus	23.88	9.52	17	136078	977	79607316
Exposure via breast milk	23.85	9.52	17	136078	979	79607314
Blood calcium increased	23.84	9.52	54	136041	10346	79597947
Intentional product use issue	23.68	9.52	157	135938	151955	79456338
Accidental exposure to product	23.53	9.52	12	136083	31310	79576983
Thrombosis	23.45	9.52	233	135862	83867	79524426
SARS-CoV-2 test negative	23.13	9.52	19	136076	1352	79606941
Lip pruritus	22.84	9.52	16	136079	896	79607397
Mobility decreased	22.80	9.52	119	135976	122056	79486237
Ill-defined disorder	22.75	9.52	49	136046	65826	79542467
Chest injury	22.67	9.52	26	136069	2795	79605498
Lung opacity	22.03	9.52	35	136060	5139	79603154
Platelet count decreased	21.98	9.52	460	135635	194204	79414089
Atrial fibrillation	21.50	9.52	465	135630	197421	79410872
Gastrointestinal haemorrhage	21.49	9.52	363	135732	147356	79460937
Nasal polyps	21.39	9.52	42	136053	7285	79601008
Product prescribing error	21.38	9.52	27	136068	44786	79563507
Urinary incontinence	21.27	9.52	131	135964	40778	79567515
Bone marrow failure	21.20	9.52	34	136061	51073	79557220
Abortion spontaneous	21.15	9.52	12	136083	29495	79578798
Cytokine release syndrome	21.12	9.52	119	135976	35879	79572414
Injection site pruritus	20.67	9.52	25	136070	42258	79566035
Renal impairment	20.67	9.52	171	135924	157612	79450681
Atelectasis	20.52	9.52	109	135986	32148	79576145
International normalised ratio increased	20.46	9.52	228	135867	84493	79523800
Menstruation delayed	20.45	9.52	18	136077	1408	79606885
Pneumonitis	20.18	9.52	175	135920	60685	79547608
Wrong technique in product usage process	20.09	9.52	62	136033	73813	79534480
Paraneoplastic rash	19.59	9.52	7	136088	87	79608206
Dental restoration failure	19.53	9.52	15	136080	969	79607324
Drug eruption	19.41	9.52	28	136067	43907	79564386
Red blood cell count decreased	19.40	9.52	166	135929	57347	79550946
Chronic obstructive pulmonary disease	19.33	9.52	227	135868	85192	79523101
Epistaxis	19.24	9.52	282	135813	111233	79497060
Epilepsy	19.10	9.52	25	136070	40835	79567458
Therapy non-responder	18.90	9.52	87	136008	92218	79516075
Poisoning	18.52	9.52	10	136085	25262	79583031
Foetal exposure timing unspecified	18.43	9.52	6	136089	55	79608238
Bone erosion	18.34	9.52	4	136091	17843	79590450
Adverse event	18.24	9.52	48	136047	60166	79548127
Fibromyalgia	18.21	9.52	53	136042	64287	79544006
Arthritis	18.17	9.52	118	135977	114762	79493531
Musculoskeletal stiffness	18.10	9.52	201	135894	174807	79433486
Appendicolith	18.06	9.52	43	136052	8508	79599785
Cytomegalovirus infection	18.04	9.52	28	136067	42616	79565677
Aspiration	17.86	9.52	75	136020	20083	79588210
Pregnancy	17.75	9.52	12	136083	26839	79581454
Excessive eye blinking	17.75	9.52	18	136077	1683	79606610
Metastatic renal cell carcinoma	17.74	9.52	21	136074	2334	79605959
Live birth	17.71	9.52	5	136090	18739	79589554
Blood phosphorus increased	17.66	9.52	48	136047	10299	79597994
Ascites	17.63	9.52	202	135893	75360	79532933
Hip arthroplasty	17.63	9.52	21	136074	35735	79572558
Respiratory failure	17.43	9.52	418	135677	180493	79427800
Toxic epidermal necrolysis	17.26	9.52	31	136064	44550	79563743
Obstructive airways disorder	17.16	9.52	102	135993	31357	79576936
Accident	17.16	9.52	43	136052	8788	79599505
Ecchymosis	17.09	9.52	61	136034	15145	79593148
Uterine perforation	17.05	9.52	35	136060	6268	79602025
Hypersensitivity	17.05	9.52	330	135765	261909	79346384
Accidental death	16.88	9.52	28	136067	4263	79604030
Sleep apnoea syndrome	16.63	9.52	113	135982	36365	79571928
Chills	16.60	9.52	374	135721	159860	79448433
Device expulsion	16.51	9.52	12	136083	25849	79582444
Lactic acidosis	16.45	9.52	63	136032	70296	79537997
Rash	16.45	9.52	813	135282	577545	79030748
Ileus	16.28	9.52	88	136007	26123	79582170
Overdose	16.24	9.52	219	135876	183987	79424306
Metabolic encephalopathy	16.18	9.52	43	136052	9104	79599189
Metabolic acidosis	16.18	9.52	79	136016	82450	79525843
Post procedural complication	16.18	9.52	82	136013	23747	79584546
Intentional self-injury	16.03	9.52	19	136076	32400	79575893
Decreased appetite	15.99	9.52	726	135369	341692	79266601
Pulmonary vasculitis	15.98	9.52	12	136083	749	79607544
Neuropathy peripheral	15.97	9.52	334	135761	140971	79467322
Iron deficiency anaemia	15.82	9.52	86	136009	25586	79582707
Dysmetropsia	15.71	9.52	6	136089	91	79608202
Painful respiration	15.60	9.52	24	136071	3429	79604864
Neuralgia	15.57	9.52	104	135991	33280	79575013
Calculus bladder	15.20	9.52	15	136080	1357	79606936
Drug-induced liver injury	14.95	9.52	60	136035	66057	79542236
Coeliac disease	14.93	9.52	48	136047	11303	79596990
Cholelithiasis	14.72	9.52	146	135949	52518	79555775
Myasthenia gravis	14.62	9.52	45	136050	10354	79597939
Hyperaesthesia	14.58	9.52	50	136045	12172	79596121
Colitis ulcerative	14.52	9.52	23	136072	34719	79573574
Hepatitis	14.29	9.52	48	136047	55679	79552614
Osteonecrosis of jaw	14.23	9.52	33	136062	43193	79565100
Cerebrovascular accident	14.11	9.52	356	135739	154936	79453357
Carbohydrate antigen 125 increased	14.07	9.52	18	136077	2166	79606127
Acute generalised exanthematous pustulosis	13.90	9.52	6	136089	17248	79591045
Intestinal obstruction	13.90	9.52	123	135972	42897	79565396
Rhabdomyolysis	13.85	9.52	111	135984	103020	79505273
Rubber sensitivity	13.85	9.52	16	136079	1733	79606560
Neuritis	13.78	9.52	16	136079	1742	79606551
Nasopharyngitis	13.74	9.52	329	135766	253552	79354741
Haemorrhage intracranial	13.70	9.52	84	136011	26109	79582184
Presyncope	13.58	9.52	118	135977	40936	79567357
Urinary retention	13.49	9.52	152	135943	56478	79551815
Duodenal stenosis	13.48	9.52	11	136084	776	79607517
Gamma-glutamyltransferase increased	13.42	9.52	48	136047	54632	79553661
Neurogenic bladder	13.35	9.52	25	136070	4187	79604106
Polyneuropathy	13.22	9.52	13	136082	24138	79584155
Anaemia	13.21	9.52	905	135190	444110	79164183
Pruritus	13.19	9.52	545	135550	394103	79214190
Drug tolerance decreased	13.15	9.52	3	136092	12975	79595318
Myotonic dystrophy	13.14	9.52	6	136089	145	79608148
Oral pain	13.03	9.52	96	135999	31702	79576591
Muscular weakness	13.03	9.52	363	135732	160366	79447927
Haemophagocytic lymphohistiocytosis	12.85	9.52	11	136084	21826	79586467
Labelled drug-drug interaction medication error	12.84	9.52	17	136078	27633	79580660
Noninfectious peritonitis	12.83	9.52	7	136088	250	79608043
Heparin-induced thrombocytopenia	12.79	9.52	41	136054	9641	79598652
Infusion related reaction	12.56	9.52	298	135797	229939	79378354
Walking aid user	12.53	9.52	42	136053	10106	79598187
Pathological fracture	12.47	9.52	43	136052	10494	79597799
Non-small cell lung cancer	12.39	9.52	31	136064	6329	79601964
Blood bilirubin decreased	12.37	9.52	12	136083	1063	79607230
Urinary tract obstruction	12.35	9.52	26	136069	4739	79603554
Posture abnormal	12.32	9.52	23	136072	3843	79604450
Cardiac failure	12.27	9.52	188	135907	154654	79453639
Oral pustule	12.25	9.52	7	136088	274	79608019
Iron deficiency	12.20	9.52	43	136052	10611	79597682
Injection site warmth	12.17	9.52	5	136090	14802	79593491
Liver disorder	12.16	9.52	73	136022	72344	79535949
Pneumonectomy	12.16	9.52	5	136090	93	79608200
Aspergillus infection	12.09	9.52	9	136086	19152	79589141
Nasal discharge discolouration	12.07	9.52	18	136077	2503	79605790
Multiple sclerosis	11.99	9.52	72	136023	22210	79586083
Airway burns	11.98	9.52	3	136092	9	79608284
Paratracheal lymphadenopathy	11.95	9.52	6	136089	180	79608113
Hypoacusis	11.78	9.52	90	136005	30060	79578233
Epiglottic erythema	11.72	9.52	4	136091	43	79608250
Impaired quality of life	11.60	9.52	5	136090	14381	79593912
Urinary retention postoperative	11.57	9.52	6	136089	193	79608100
Catheter site bruise	11.39	9.52	8	136087	450	79607843
Aortic aneurysm	11.37	9.52	36	136059	8410	79599883
Malignant neoplasm of thorax	11.32	9.52	3	136092	12	79608281
Spinal cord compression	11.30	9.52	30	136065	6347	79601946
Emotional distress	11.27	9.52	111	135984	39858	79568435
Dyspnoea exertional	11.24	9.52	210	135885	86863	79521430
Tuberculosis	11.16	9.52	6	136089	15192	79593101
Ageusia	11.13	9.52	57	136038	16575	79591718
Inguinal hernia	10.98	9.52	30	136065	6458	79601835
Delirium	10.89	9.52	204	135891	84423	79523870
Respiratory depression	10.89	9.52	19	136076	27611	79580682
Immunodeficiency	10.87	9.52	69	136026	21699	79586594
Musculoskeletal chest pain	10.87	9.52	76	136019	24688	79583605
Shock haemorrhagic	10.75	9.52	11	136084	20049	79588244
Heart rate increased	10.74	9.52	276	135819	120448	79487845
Injection site bruising	10.73	9.52	35	136060	40967	79567326
Blood test abnormal	10.69	9.52	59	136036	17651	79590642
Pleurothotonus	10.69	9.52	17	136078	2499	79605794
Circulatory collapse	10.68	9.52	31	136064	37637	79570656
Onychoclasis	10.67	9.52	27	136068	5551	79602742
Therapeutic response shortened	10.61	9.52	7	136088	15856	79592437
Tremor	10.58	9.52	372	135723	169711	79438582
Eosinophil count decreased	10.57	9.52	20	136075	3376	79604917
Pneumonia viral	10.52	9.52	37	136058	9121	79599172
Perirectal abscess	10.39	9.52	15	136080	2026	79606267
Impaired work ability	10.31	9.52	11	136084	19670	79588623
Urosepsis	10.30	9.52	79	136016	26416	79581877
Diabetes mellitus inadequate control	10.20	9.52	16	136079	24248	79584045
Catheter site pain	10.20	9.52	26	136069	5370	79602923
Hepatotoxicity	10.16	9.52	49	136046	51303	79556990
Sexually inappropriate behaviour	10.15	9.52	8	136087	537	79607756
Coma	10.13	9.52	234	135861	100415	79507878
Pulmonary hypertension	10.10	9.52	126	135969	47954	79560339
Sitting disability	10.02	9.52	7	136088	390	79607903
Phlebosclerosis	10.02	9.52	5	136090	148	79608145
Abdominal mass	9.96	9.52	20	136075	3525	79604768
Seizure like phenomena	9.91	9.52	14	136081	1853	79606440
Type 2 diabetes mellitus	9.90	9.52	57	136038	57065	79551228
Dry skin	9.85	9.52	167	135928	67828	79540465
Convulsive threshold lowered	9.84	9.52	10	136085	937	79607356
Sleep disorder	9.84	9.52	96	135999	85581	79522712
Hospitalisation	9.77	9.52	220	135875	94016	79514277
Non-cardiac chest pain	9.69	9.52	37	136058	9487	79598806
Gastrointestinal arteriovenous malformation	9.66	9.52	10	136085	958	79607335
Oesophageal ulcer	9.64	9.52	30	136065	6945	79601348
Drooling	9.61	9.52	27	136068	5907	79602386
Blood loss anaemia	9.60	9.52	52	136043	15446	79592847
Depressed level of consciousness	9.60	9.52	112	135983	96540	79511753
Anal injury	9.58	9.52	5	136090	163	79608130
Intentional product misuse	9.56	9.52	110	135985	95055	79513238
Posterior reversible encephalopathy syndrome	9.54	9.52	19	136076	26262	79582031
Drug therapy	9.53	9.52	11	136084	1190	79607103

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

Source	Code	Description
ATC	A06AA02	ALIMENTARY TRACT AND METABOLISM DRUGS FOR CONSTIPATION DRUGS FOR CONSTIPATION Softeners, emollients
ATC	A06AG10	ALIMENTARY TRACT AND METABOLISM DRUGS FOR CONSTIPATION DRUGS FOR CONSTIPATION Enemas
MeSH PA	D013501	Surface-Active Agents

Drug Use | Suggest Off label Use Form| |View source of the data|

Disease	Relation	SNOMED_ID	DOID
Constipation	indication	14760008	DOID:2089
Megaloblastic anemia due to folate deficiency	indication	85649008	DOID:14026
Iron deficiency anemia	indication	87522002
Pregnancy, function	indication	289908002
Breastfeeding (mother)	indication	413712001
Incomplete passage of stool	off-label use	249515001
Prevention of Fetal Neural Tube Defects during Pregnancy	off-label use
Peptic ulcer	contraindication	13200003	DOID:750
Primary hyperoxaluria	contraindication	17901006	DOID:2977
Gastroenteritis	contraindication	25374005	DOID:2326
Hemosiderosis	contraindication	39011001	DOID:12119
Hypokalemia	contraindication	43339004
Bleeding hemorrhoids	contraindication	51551000
Gastrectomy	contraindication	53442002
Leber's optic atrophy	contraindication	58610003	DOID:705
Hemolytic anemia	contraindication	61261009	DOID:583
Ulcerative colitis	contraindication	64766004	DOID:8577
Incontinence of feces	contraindication	72042002
Appendicitis	contraindication	74400008	DOID:8337
Atrophic gastritis	contraindication	84568007	DOID:8929
Disorder of mucous membrane	contraindication	95351003
Anemia due to enzyme deficiency	contraindication	111577008
Gastrointestinal obstruction	contraindication	126765001
Hb SS disease	contraindication	127040003	DOID:10923
Urinary incontinence	contraindication	165232002
Diverticular disease	contraindication	397881000
Hemochromatosis	contraindication	399187006	DOID:2352
Repeated Blood Transfusions	contraindication

🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation level	Dissociation constant	Type (acidic/basic)
pKa1	12.0	acidic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

None

External reference:

ID	Source
4019731	VUID
N0000179792	NUI
D03885	KEGG_DRUG
128-49-4	SECONDARY_CAS_RN
71722	RXNORM
4017673	VANDF
4019248	VANDF
4019731	VANDF
C0243237	UMLSCUI
CHEBI:4674	CHEBI
CHEMBL1905872	ChEMBL_ID
CHEMBL1477036	ChEMBL_ID
CHEMBL2106608	ChEMBL_ID
531	INN_ID
F05Q2T2JA0	UNII
23673837	PUBCHEM_CID
DB11089	DRUGBANK_ID
29340	MMSL
4627	MMSL
4629	MMSL
6142	MMSL
6143	MMSL
NOCODE	MMSL
d01021	MMSL
001180	NDDF
001181	NDDF
001183	NDDF
116528004	SNOMEDCT_US
387088007	SNOMEDCT_US
418528006	SNOMEDCT_US
418700002	SNOMEDCT_US
D004143	MESH_DESCRIPTOR_UI
577-11-7	SECONDARY_CAS_RN

Pharmaceutical products:

Product	Category	Ingredients	NDC	Form	Quantity	Route	Marketing	Label
good sense stool softener	HUMAN OTC DRUG LABEL	1	0113-0486	CAPSULE, LIQUID FILLED	100 mg	ORAL	OTC monograph not final	15 sections
basic care stool softener	HUMAN OTC DRUG LABEL	1	0113-7004	CAPSULE, LIQUID FILLED	100 mg	ORAL	OTC monograph not final	15 sections
Docusate Sodium	HUMAN OTC DRUG LABEL	1	0121-0544	LIQUID	50 mg	ORAL	OTC monograph not final	15 sections
Docusate Sodium	HUMAN OTC DRUG LABEL	1	0121-0935	LIQUID	50 mg	ORAL	OTC monograph not final	15 sections
Docusate Sodium	HUMAN OTC DRUG LABEL	1	0121-1870	LIQUID	100 mg	ORAL	OTC monograph not final	15 sections
Pedia-Lax	HUMAN OTC DRUG LABEL	1	0132-0106	LIQUID	50 mg	ORAL	OTC monograph not final	10 sections
Pedia-Lax	HUMAN OTC DRUG LABEL	1	0132-0107	LIQUID	50 mg	ORAL	OTC monograph not final	13 sections
Ferralet 90	HUMAN PRESCRIPTION DRUG LABEL	5	0178-0089	TABLET, FILM COATED	50 mg	ORAL	unapproved drug other	17 sections
Ferralet 90	HUMAN PRESCRIPTION DRUG LABEL	5	0178-0089	TABLET, FILM COATED	50 mg	ORAL	unapproved drug other	17 sections
CitraNatal Harmony 3.0	HUMAN PRESCRIPTION DRUG LABEL	8	0178-0796	CAPSULE, GELATIN COATED	50 mg	ORAL	unapproved drug other	10 sections
CitraNatal Harmony 3.0	HUMAN PRESCRIPTION DRUG LABEL	8	0178-0796	CAPSULE, GELATIN COATED	50 mg	ORAL	unapproved drug other	10 sections
CitraNatal Harmony	HUMAN PRESCRIPTION DRUG LABEL	8	0178-0798	CAPSULE, GELATIN COATED	50 mg	ORAL	UNAPPROVED DRUG OTHER	11 sections
CitraNatal Harmony	HUMAN PRESCRIPTION DRUG LABEL	8	0178-0799	CAPSULE, GELATIN COATED	50 mg	ORAL	Unapproved drug other	11 sections
CitraNatal Harmony	HUMAN PRESCRIPTION DRUG LABEL	8	0178-0812	CAPSULE, GELATIN COATED	50 mg	ORAL	Unapproved drug other	11 sections
CitraNatal Bloom	HUMAN PRESCRIPTION DRUG LABEL	6	0178-0813	TABLET, FILM COATED	55 mg	ORAL	unapproved drug other	15 sections
CitraNatal Bloom	HUMAN PRESCRIPTION DRUG LABEL	6	0178-0813	TABLET, FILM COATED	55 mg	ORAL	unapproved drug other	15 sections
CitraNatal Bloom	HUMAN PRESCRIPTION DRUG LABEL	6	0178-0813	TABLET, FILM COATED	55 mg	ORAL	unapproved drug other	15 sections
CitraNatal 90 DHA	HUMAN PRESCRIPTION DRUG LABEL	16	0178-0821	TABLET	50 mg	ORAL	unapproved drug other	11 sections
CitraNatal 90 DHA	HUMAN PRESCRIPTION DRUG LABEL	16	0178-0821	TABLET	50 mg	ORAL	unapproved drug other	11 sections
CitraNatal 90 DHA	HUMAN OTC DRUG LABEL	14	0178-0829	TABLET	50 mg	ORAL	Unapproved drug other	11 sections
CitraNatal Rx	HUMAN PRESCRIPTION DRUG LABEL	14	0178-0859	TABLET	50 mg	ORAL	Unapproved drug other	9 sections
CitraNatal DHA	HUMAN OTC DRUG LABEL	14	0178-0898	TABLET	50 mg	ORAL	Unapproved drug other	11 sections
Phillips Stool SoftenerBulk Docusate	HUMAN OTC DRUG LABEL	1	0280-1012	CAPSULE, LIQUID FILLED	100 mg	ORAL	OTC monograph not final	15 sections
Phillips Stool SoftenerBulk Docusate	HUMAN OTC DRUG LABEL	1	0280-1012	CAPSULE, LIQUID FILLED	100 mg	ORAL	OTC monograph not final	15 sections
Phillips Stool SoftenerBulk Docusate	HUMAN OTC DRUG LABEL	1	0280-1012	CAPSULE, LIQUID FILLED	100 mg	ORAL	OTC monograph not final	15 sections
Phillips Stool SoftenerBulk Docusate	HUMAN OTC DRUG LABEL	1	0280-1012	CAPSULE, LIQUID FILLED	100 mg	ORAL	OTC monograph not final	15 sections
Stool Softener Laxative	HUMAN OTC DRUG LABEL	1	0363-0016	CAPSULE, LIQUID FILLED	100 mg	ORAL	OTC MONOGRAPH NOT FINAL	14 sections
Stool Softener	HUMAN OTC DRUG LABEL	1	0363-0257	CAPSULE, LIQUID FILLED	240 mg	ORAL	OTC monograph not final	14 sections
Stool SoftenerPlus Stimulant Laxative	HUMAN OTC DRUG LABEL	2	0363-0584	TABLET	50 mg	ORAL	OTC MONOGRAPH NOT FINAL	14 sections
Stool SoftenerPlus Stimulant Laxative	HUMAN OTC DRUG LABEL	2	0363-0584	TABLET	50 mg	ORAL	OTC MONOGRAPH NOT FINAL	14 sections