docusate sodium 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
941 10041-19-7

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • docusate
  • dioctyl sulfosuccinate
  • dioctyl sulfosuccinic acid
  • docusate sodium
  • docusate calcium
  • dioctyl disodium sulfosuccinate
All-purpose surfactant, wetting agent, and solubilizer used in the drug, cosmetics, and food industries. It has also been used in laxatives and as cerumenolytics. It is usually administered as either the calcium, potassium, or sodium salt.
  • Molecular weight: 422.58
  • Formula: C20H38O7S
  • CLOGP: 5.46
  • LIPINSKI: 1
  • HAC: 7
  • HDO: 1
  • TPSA: 106.97
  • ALOGS: -5.02
  • ROTB: 18

Drug dosage:

DoseUnitRoute
0.15 g O

ADMET properties:

None

Approvals:

DateAgencyCompanyOrphan
None FDA

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Drug ineffective 377.03 9.85 692 101191 1044073 62343066
Constipation 373.77 9.85 992 100891 223951 63163188
Systemic lupus erythematosus 271.08 9.85 16 101867 208902 63178237
Pemphigus 269.86 9.85 5 101878 183721 63203418
Synovitis 256.36 9.85 10 101873 186908 63200231
Hand deformity 231.52 9.85 5 101878 159452 63227687
Pneumonia aspiration 206.85 9.85 266 101617 34274 63352865
Glossodynia 178.71 9.85 35 101848 178841 63208298
Arthropathy 170.16 9.85 82 101801 234710 63152429
Maternal exposure during pregnancy 165.45 9.85 73 101810 219989 63167150
Therapeutic product effect decreased 163.72 9.85 53 101830 193134 63194005
Contraindicated product administered 159.26 9.85 75 101808 217573 63169566
Gastrooesophageal reflux disease 144.71 9.85 408 101475 95231 63291908
Discomfort 133.09 9.85 51 101832 167323 63219816
Duodenal ulcer perforation 125.51 9.85 3 101880 87206 63299933
Wound 121.35 9.85 55 101828 163208 63223931
Pericarditis 118.93 9.85 32 101851 131547 63255592
Completed suicide 116.46 9.85 44 101839 145629 63241510
Urinary tract infection 116.41 9.85 775 101108 263909 63123230
Drug intolerance 112.56 9.85 202 101681 308459 63078680
Joint swelling 109.42 9.85 226 101657 327440 63059699
Helicobacter infection 109.33 9.85 11 101872 92774 63294365
Swelling 107.02 9.85 173 101710 275205 63111934
Plasma cell myeloma 106.61 9.85 200 101683 35705 63351434
Pulmonary embolism 105.19 9.85 418 101465 116266 63270873
Treatment failure 98.94 9.85 104 101779 198939 63188200
Deep vein thrombosis 98.22 9.85 327 101556 83473 63303666
Alopecia 98.01 9.85 251 101632 337285 63049854
Mental status changes 91.80 9.85 199 101684 39400 63347739
Psoriatic arthropathy 91.16 9.85 18 101865 91502 63295637
Folliculitis 89.29 9.85 6 101877 70311 63316828
Back pain 84.18 9.85 717 101166 263428 63123711
Pulmonary malformation 82.30 9.85 27 101856 272 63386867
Death 79.01 9.85 933 100950 373448 63013691
Salpingo-oophorectomy unilateral 78.74 9.85 35 101848 846 63386293
Off label use 74.10 9.85 709 101174 673753 62713386
Abdominal discomfort 73.54 9.85 266 101617 320619 63066520
Pneumonia 73.35 9.85 1083 100800 455684 62931455
Sinusitis fungal 72.66 9.85 42 101841 1789 63385350
Coma 70.00 9.85 245 101638 64119 63323020
Dehydration 69.83 9.85 497 101386 172857 63214282
Sputum increased 68.48 9.85 45 101838 2414 63384725
Asthenia 68.15 9.85 926 100957 382678 63004461
Sleep disorder due to general medical condition, insomnia type 67.66 9.85 4 101879 52213 63334926
Anti-neutrophil cytoplasmic antibody positive vasculitis 66.36 9.85 47 101836 2852 63384287
Product use issue 66.27 9.85 161 101722 220359 63166780
Somnolence 66.10 9.85 502 101381 178183 63208956
Irritable bowel syndrome 65.66 9.85 25 101858 82387 63304752
Pleural effusion 64.89 9.85 309 101574 92901 63294238
Condition aggravated 63.95 9.85 381 101502 401836 62985303
Abdominal pain 63.47 9.85 735 101148 292721 63094418
Arthralgia 62.45 9.85 599 101284 569111 62818028
Hepatic enzyme increased 62.15 9.85 146 101737 202182 63184957
Embolism venous 60.59 9.85 46 101837 3108 63384031
Rheumatoid arthritis 59.72 9.85 208 101675 253611 63133528
Lung cyst 59.63 9.85 22 101861 322 63386817
C-reactive protein increased 57.32 9.85 41 101842 94666 63292473
General physical health deterioration 56.68 9.85 152 101731 201250 63185889
Liver injury 56.04 9.85 14 101869 60506 63326633
Therapeutic product effect incomplete 55.99 9.85 71 101812 124985 63262154
Hiatus hernia 55.25 9.85 113 101770 21481 63365658
Diverticulum 54.69 9.85 81 101802 11910 63375229
Respiratory symptom 53.92 9.85 44 101839 3303 63383836
Diastolic dysfunction 53.89 9.85 59 101824 6412 63380727
Intentional overdose 53.49 9.85 26 101857 74126 63313013
Toxicity to various agents 53.33 9.85 210 101673 247040 63140099
Oedema peripheral 52.91 9.85 500 101383 189011 63198128
Drug interaction 51.09 9.85 192 101691 228939 63158200
Hypoxia 50.50 9.85 210 101673 59582 63327557
Nausea 49.79 9.85 1754 100129 852717 62534422
Exposure during pregnancy 47.95 9.85 112 101771 155435 63231704
Respiratory tract malformation 47.43 9.85 16 101867 177 63386962
Full blood count decreased 47.40 9.85 119 101764 25905 63361234
Infection 46.69 9.85 199 101684 228974 63158165
Tricuspid valve incompetence 46.61 9.85 84 101799 14537 63372602
Small intestinal obstruction 45.79 9.85 95 101788 18242 63368897
Haemoglobin decreased 45.78 9.85 394 101489 145091 63242048
Intestinal pseudo-obstruction 44.60 9.85 24 101859 888 63386251
Temperature regulation disorder 44.42 9.85 52 101831 6080 63381059
Blister 43.70 9.85 89 101794 129725 63257414
Impaired healing 43.07 9.85 61 101822 102481 63284658
Fungal infection 42.39 9.85 143 101740 36731 63350408
Drug hypersensitivity 41.92 9.85 309 101574 310378 63076761
Fall 41.25 9.85 870 101013 391464 62995675
Hospice care 41.19 9.85 57 101826 7875 63379264
Disease progression 41.03 9.85 337 101546 122421 63264718
Cardiac failure congestive 40.13 9.85 270 101613 92163 63294976
Suicide attempt 40.08 9.85 24 101859 60894 63326245
Chest pain 39.36 9.85 524 101359 215435 63171704
Failure to thrive 39.31 9.85 53 101830 7145 63379994
Red blood cell sedimentation rate increased 39.15 9.85 11 101872 43971 63343168
White blood cell count decreased 37.80 9.85 365 101518 138739 63248400
Lethargy 37.76 9.85 184 101699 55823 63331316
Cestode infection 37.71 9.85 15 101868 272 63386867
Upper respiratory tract infection 36.42 9.85 241 101642 81806 63305333
Rash 36.22 9.85 658 101225 560213 62826926
Chronic sinusitis 36.21 9.85 70 101813 12773 63374366
Knee arthroplasty 36.16 9.85 21 101862 54185 63332954
Product use in unapproved indication 35.55 9.85 157 101726 178923 63208216
Nasal polyps 33.79 9.85 45 101838 5994 63381145
Drug abuse 33.68 9.85 40 101843 72478 63314661
Vomiting 33.00 9.85 1151 100732 558466 62828673
Emphysema 32.55 9.85 61 101822 10877 63376262
Febrile neutropenia 32.27 9.85 311 101572 118138 63269001
Infusion related reaction 32.24 9.85 246 101637 245275 63141864
Total lung capacity decreased 31.65 9.85 27 101856 2156 63384983
Peritonitis bacterial 31.46 9.85 39 101844 4840 63382299
Gastrointestinal disorder 31.20 9.85 107 101776 131132 63256007
Hip arthroplasty 31.02 9.85 19 101864 47627 63339512
Abortion spontaneous 30.48 9.85 19 101864 47176 63339963
Hip fracture 30.16 9.85 110 101773 29364 63357775
Magnesium deficiency 30.13 9.85 16 101867 576 63386563
Dyspnoea 30.03 9.85 1322 100561 659991 62727148
Hypervolaemia 29.89 9.85 107 101776 28306 63358833
Platelet count decreased 29.74 9.85 301 101582 115821 63271318
Cellulitis 28.46 9.85 227 101656 81731 63305408
Acute respiratory failure 28.24 9.85 120 101763 34365 63352774
Musculoskeletal stiffness 28.16 9.85 177 101706 184441 63202698
Fluid retention 28.13 9.85 178 101705 59508 63327631
Iron deficiency anaemia 28.05 9.85 83 101800 19886 63367253
Mobility decreased 27.98 9.85 100 101783 121059 63266080
Blood cholesterol increased 27.94 9.85 69 101814 93963 63293176
Injection site reaction 27.48 9.85 32 101851 58492 63328647
Female genital tract fistula 27.45 9.85 46 101837 7513 63379626
Premenstrual syndrome 27.23 9.85 16 101867 703 63386436
Food allergy 27.22 9.85 58 101825 11343 63375796
Device expulsion 27.14 9.85 11 101872 34911 63352228
Lactation disorder 27.06 9.85 13 101870 377 63386762
Hysterectomy 27.06 9.85 52 101831 9447 63377692
Exposure via breast milk 26.92 9.85 24 101859 2033 63385106
Bronchopulmonary aspergillosis allergic 26.91 9.85 25 101858 2233 63384906
Ill-defined disorder 26.71 9.85 57 101826 81698 63305441
Poor sucking reflex 26.62 9.85 12 101871 300 63386839
Lung opacity 26.58 9.85 29 101854 3139 63384000
Drug resistance 26.29 9.85 3 101880 22930 63364209
Blood potassium decreased 26.16 9.85 135 101748 41891 63345248
Atrial fibrillation 25.99 9.85 294 101589 116342 63270797
Neutrophil count decreased 25.83 9.85 167 101716 56239 63330900
Autonomic dysreflexia 25.77 9.85 12 101871 324 63386815
Live birth 25.60 9.85 5 101878 25625 63361514
Lip pruritus 25.57 9.85 17 101866 930 63386209
Hypersensitivity 25.48 9.85 324 101559 292361 63094778
International normalised ratio increased 25.42 9.85 144 101739 46281 63340858
Abdominal distension 25.38 9.85 231 101652 86384 63300755
Excessive eye blinking 25.32 9.85 19 101864 1261 63385878
Anaemia 25.00 9.85 632 101251 292798 63094341
Interstitial lung disease 24.85 9.85 38 101845 61870 63325269
Injection site erythema 24.73 9.85 61 101822 83113 63304026
Hyponatraemia 24.45 9.85 281 101602 111619 63275520
Maternal exposure during breast feeding 24.34 9.85 32 101851 4209 63382930
Blood calcium increased 24.00 9.85 49 101834 9301 63377838
Type 2 diabetes mellitus 23.95 9.85 41 101842 63827 63323312
Polymenorrhoea 23.88 9.85 18 101865 1203 63385936
Unresponsive to stimuli 23.44 9.85 112 101771 33704 63353435
Lichen sclerosus 23.15 9.85 17 101866 1092 63386047
Intentional product use issue 23.09 9.85 116 101767 127776 63259363
Injection site pruritus 23.04 9.85 23 101860 45093 63342046
Sleep apnoea syndrome 22.80 9.85 100 101783 29033 63358106
Dental restoration failure 22.59 9.85 16 101867 971 63386168
Gastrointestinal haemorrhage 22.53 9.85 214 101669 80962 63306177
Carbohydrate antigen 125 increased 22.29 9.85 25 101858 2791 63384348
Obstructive airways disorder 21.81 9.85 78 101805 20621 63366518
Therapy non-responder 21.54 9.85 57 101826 75844 63311295
Granulocytopenia 21.25 9.85 35 101848 5637 63381502
Aspiration 21.22 9.85 51 101832 10800 63376339
Neuropathy peripheral 21.18 9.85 277 101606 113390 63273749
Accidental exposure to product 20.71 9.85 9 101874 27396 63359743
Fatigue 20.56 9.85 1672 100211 886356 62500783
Hyperaesthesia 20.52 9.85 46 101837 9312 63377827
Chronic obstructive pulmonary disease 20.35 9.85 171 101712 62515 63324624
Immunodeficiency 20.22 9.85 75 101808 20179 63366960
Injection site pain 19.50 9.85 125 101758 129675 63257464
Respiratory failure 19.30 9.85 249 101634 101609 63285530
Hypophagia 19.17 9.85 100 101783 31159 63355980
Thrombosis 19.12 9.85 173 101710 64582 63322557
Grip strength decreased 19.06 9.85 6 101877 22281 63364858
Adverse event 18.97 9.85 51 101832 67508 63319631
Hypotension 18.93 9.85 572 101311 272032 63115107
Inflammation 18.93 9.85 68 101815 82205 63304934
Drug-induced liver injury 18.88 9.85 22 101861 40200 63346939
Premature baby 18.80 9.85 5 101878 20730 63366409
Cytokine release syndrome 18.70 9.85 58 101825 14256 63372883
Sepsis 18.53 9.85 347 101536 152776 63234363
Menstruation delayed 18.43 9.85 18 101865 1711 63385428
Injection site swelling 18.33 9.85 30 101853 47542 63339597
Haematocrit decreased 18.33 9.85 117 101766 39223 63347916
Dysphagia 18.26 9.85 220 101663 88365 63298774
Rheumatoid nodule 17.88 9.85 3 101880 17152 63369987
Emotional distress 17.85 9.85 101 101782 32448 63354691
Coeliac disease 17.79 9.85 53 101830 12744 63374395
Drug reaction with eosinophilia and systemic symptoms 17.56 9.85 17 101866 33819 63353320
Uterine perforation 17.30 9.85 36 101847 6927 63380212
Noninfectious peritonitis 17.20 9.85 7 101876 135 63387004
Urticaria 16.96 9.85 177 101706 165625 63221514
Dysmetropsia 16.91 9.85 6 101877 78 63387061
Onychoclasis 16.44 9.85 33 101850 6189 63380950
Lower gastrointestinal haemorrhage 16.43 9.85 38 101845 7852 63379287
Decreased appetite 16.43 9.85 523 101360 250529 63136610
Presyncope 16.43 9.85 88 101795 27697 63359442
Myelosuppression 16.07 9.85 9 101874 23694 63363445
Epistaxis 16.05 9.85 183 101700 72542 63314597
Flatulence 16.04 9.85 103 101780 34599 63352540
Loss of personal independence in daily activities 16.02 9.85 91 101792 97199 63289940
Body temperature fluctuation 15.93 9.85 19 101864 2266 63384873
Oesophageal ulcer 15.88 9.85 27 101856 4463 63382676
Tremor 15.77 9.85 299 101584 131940 63255199
Intestinal obstruction 15.72 9.85 94 101789 30805 63356334
Multiple sclerosis 15.66 9.85 79 101804 24293 63362846
Drug ineffective for unapproved indication 15.59 9.85 19 101864 34044 63353095
Candida infection 15.56 9.85 88 101795 28263 63358876
Lip dry 15.49 9.85 3 101880 15467 63371672
Pregnancy 15.37 9.85 22 101861 36814 63350325
Duodenal stenosis 15.29 9.85 10 101873 532 63386607
Anxiety 15.24 9.85 457 101426 217084 63170055
Proteinuria 15.20 9.85 66 101817 19079 63368060
Fibromyalgia 15.05 9.85 72 101811 80348 63306791
Electrocardiogram PR prolongation 14.89 9.85 11 101872 713 63386426
Cholelithiasis 14.88 9.85 121 101762 43804 63343335
Atelectasis 14.78 9.85 71 101812 21412 63365727
Palmoplantar keratoderma 14.50 9.85 17 101866 1990 63385149
Nasal discharge discolouration 14.40 9.85 18 101865 2253 63384886
Medication error 14.28 9.85 40 101843 52244 63334895
Stomatitis 14.23 9.85 148 101735 138577 63248562
Heart rate increased 14.09 9.85 221 101662 94017 63293122
Decubitus ulcer 14.09 9.85 43 101840 10477 63376662
Joint range of motion decreased 13.90 9.85 19 101864 32409 63354730
Dyspnoea exertional 13.88 9.85 153 101730 60149 63326990
Blood bilirubin decreased 13.85 9.85 11 101872 794 63386345
Cerebrovascular accident 13.83 9.85 247 101636 107777 63279362
Red blood cell count decreased 13.79 9.85 112 101771 40533 63346606
Carotid artery occlusion 13.74 9.85 26 101857 4668 63382471
Anaphylactic reaction 13.68 9.85 57 101826 66043 63321096
Cholecystitis chronic 13.55 9.85 42 101841 10319 63376820
Cardiospasm 13.53 9.85 16 101867 1891 63385248
Urinary retention postoperative 13.50 9.85 5 101878 74 63387065
Anaphylactic shock 13.31 9.85 11 101872 23622 63363517
Blood loss anaemia 13.20 9.85 38 101845 8963 63378176
Injection site warmth 13.16 9.85 4 101879 15191 63371948
Drug eruption 13.14 9.85 16 101867 28678 63358461
Bone erosion 13.10 9.85 6 101877 17711 63369428
Sinus bradycardia 12.99 9.85 52 101831 14499 63372640
Foetal exposure timing unspecified 12.91 9.85 7 101876 263 63386876
Impaired work ability 12.79 9.85 6 101877 17469 63369670
Rash erythematous 12.77 9.85 114 101769 42396 63344743
Liver disorder 12.60 9.85 44 101839 53643 63333496
Epiglottic oedema 12.50 9.85 5 101878 92 63387047
Balance disorder 12.25 9.85 197 101686 84225 63302914
Pruritus genital 12.20 9.85 18 101865 2636 63384503
Gastrointestinal arteriovenous malformation 12.19 9.85 9 101874 583 63386556
Epiglottic erythema 12.13 9.85 4 101879 41 63387098
Intentional self-injury 12.11 9.85 14 101869 25673 63361466
Sleep terror 12.07 9.85 18 101865 2662 63384477
Malignant neoplasm of thorax 11.93 9.85 3 101880 10 63387129
Non-small cell lung cancer 11.90 9.85 21 101862 3574 63383565
Laboratory test abnormal 11.90 9.85 79 101804 26833 63360306
Pulmonary hypertension 11.90 9.85 101 101782 37022 63350117
Rales 11.84 9.85 46 101837 12651 63374488
Transfusion 11.73 9.85 52 101831 15165 63371974
Rhabdomyolysis 11.73 9.85 34 101849 43917 63343222
Calculus bladder 11.73 9.85 9 101874 618 63386521
Injection site rash 11.56 9.85 8 101875 18801 63368338
Weight decreased 11.55 9.85 549 101334 276249 63110890
Arteriovenous graft site infection 11.50 9.85 3 101880 12 63387127
Epilepsy 11.46 9.85 16 101867 27049 63360090
Cardiac murmur 11.42 9.85 50 101833 14502 63372637
Pneumonitis 11.38 9.85 96 101787 35126 63352013
Catheter site bruise 11.33 9.85 8 101875 483 63386656
Asthma 11.21 9.85 276 101607 127285 63259854
Pneumonia viral 11.19 9.85 33 101850 7889 63379250
Immune-mediated encephalitis 11.00 9.85 6 101877 228 63386911
Rubber sensitivity 11.00 9.85 16 101867 2315 63384824
Arthritis 10.95 9.85 126 101757 115795 63271344
Premature delivery 10.84 9.85 20 101863 30261 63356878
Burkholderia test positive 10.75 9.85 6 101877 239 63386900
Urinary incontinence 10.74 9.85 88 101795 31926 63355213
Abdominal mass 10.69 9.85 18 101865 2952 63384187
Rectal haemorrhage 10.65 9.85 123 101760 48907 63338232
Gingival pain 10.59 9.85 33 101850 8129 63379010
Urinary tract infection enterococcal 10.51 9.85 17 101866 2696 63384443
Mean platelet volume increased 10.47 9.85 8 101875 546 63386593
Faeces hard 10.46 9.85 15 101868 2142 63384997
Enterocele 10.40 9.85 4 101879 66 63387073
Haemorrhoids 10.39 9.85 66 101817 22084 63365055
Foot deformity 10.33 9.85 18 101865 27835 63359304
Hyperhidrosis 10.29 9.85 236 101647 107600 63279539
Ecchymosis 10.19 9.85 40 101843 11054 63376085
Use of accessory respiratory muscles 10.18 9.85 6 101877 265 63386874
Diarrhoea 10.15 9.85 1303 100580 714063 62673076
Sleep disorder 10.09 9.85 83 101800 81483 63305656
Lupus-like syndrome 10.09 9.85 6 101877 15289 63371850
Catheter site pain 10.07 9.85 23 101860 4712 63382427
Wrong product administered 10.07 9.85 27 101856 6114 63381025
Abdominal pain upper 10.05 9.85 416 101467 206028 63181111
Musculoskeletal chest pain 10.00 9.85 63 101820 21020 63366119
Hallucination 9.96 9.85 133 101750 54684 63332455
Embolic stroke 9.94 9.85 20 101863 3756 63383383
Peritonitis 9.92 9.85 54 101829 17100 63370039

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Constipation 202.25 10.50 652 66779 136330 34753170
Drug ineffective 198.19 10.50 363 67068 456388 34433112
Completed suicide 118.08 10.50 23 67408 98145 34791355
Drug abuse 107.66 10.50 29 67402 99067 34790433
Plasma cell myeloma 96.32 10.50 235 67196 41802 34847698
Off label use 84.18 10.50 471 66960 419053 34470447
Urinary tract infection 68.96 10.50 333 67098 83748 34805752
Mental status changes 66.99 10.50 193 67238 37890 34851610
Pneumonia 60.50 10.50 1008 66423 361619 34527881
Death 55.29 10.50 1075 66356 396974 34492526
Toxicity to various agents 52.39 10.50 204 67227 200158 34689342
Fatigue 49.07 10.50 994 66437 369659 34519841
Intentional overdose 46.99 10.50 13 67418 43661 34845839
Fall 45.94 10.50 595 66836 202290 34687210
Febrile neutropenia 43.50 10.50 429 67002 136420 34753080
Failure to thrive 43.13 10.50 67 67364 8534 34880966
Confusional state 39.72 10.50 439 66992 143721 34745779
Burkholderia test positive 37.94 10.50 24 67407 999 34888501
Dehydration 36.81 10.50 398 67033 129571 34759929
Hepatic function abnormal 36.53 10.50 20 67411 44343 34845157
Drug interaction 36.28 10.50 271 67160 225675 34663825
Product use in unapproved indication 35.80 10.50 112 67319 117387 34772113
Hypersomnia 35.77 10.50 76 67355 12331 34877169
C-reactive protein increased 35.77 10.50 31 67400 54067 34835433
Failure to suspend medication 34.88 10.50 17 67414 421 34889079
Drug resistance 33.51 10.50 5 67426 25922 34863578
Hallucination 33.27 10.50 191 67240 51307 34838193
Treatment failure 33.06 10.50 25 67406 46672 34842828
Asthenia 32.44 10.50 658 66773 244593 34644907
Hospice care 31.96 10.50 52 67379 6888 34882612
Interstitial lung disease 31.68 10.50 48 67383 65234 34824266
Accident 30.62 10.50 43 67388 5004 34884496
Anal inflammation 30.48 10.50 23 67408 1277 34888223
Vomiting 30.34 10.50 657 66774 246964 34642536
Hypoxia 30.30 10.50 196 67235 54899 34834601
Walking aid user 30.30 10.50 27 67404 1897 34887603
Painful respiration 29.28 10.50 22 67409 1214 34888286
Full blood count decreased 29.25 10.50 89 67342 17999 34871501
Cholestasis 29.03 10.50 8 67423 26940 34862560
Therapeutic product effect incomplete 28.78 10.50 33 67398 50508 34838992
Accidental death 28.28 10.50 29 67402 2427 34887073
Coma 28.04 10.50 28 67403 45650 34843850
Back pain 27.43 10.50 357 67074 121432 34768068
Sepsis 26.16 10.50 459 66972 166102 34723398
Renal impairment 26.10 10.50 94 67337 94419 34795081
SARS-CoV-2 test negative 26.06 10.50 19 67412 1001 34888499
Proctalgia 25.17 10.50 42 67389 5681 34883819
Hepatocellular injury 25.06 10.50 6 67425 22205 34867295
Small intestinal obstruction 24.84 10.50 74 67357 14792 34874708
Granulocytopenia 24.72 10.50 45 67386 6522 34882978
Unresponsive to stimuli 24.63 10.50 112 67319 27457 34862043
Chest injury 24.41 10.50 22 67409 1569 34887931
Drug reaction with eosinophilia and systemic symptoms 24.24 10.50 17 67414 32995 34856505
Deep vein thrombosis 23.93 10.50 211 67220 65037 34824463
Peripheral artery thrombosis 23.86 10.50 26 67405 2334 34887166
Rheumatoid arthritis 22.83 10.50 24 67407 38214 34851286
Intestinal pseudo-obstruction 22.55 10.50 22 67409 1734 34887766
Hyponatraemia 21.91 10.50 250 67181 82441 34807059
Peripheral swelling 21.46 10.50 234 67197 76307 34813193
Condition aggravated 21.17 10.50 253 67178 191943 34697557
Pleural effusion 20.92 10.50 245 67186 81301 34808199
Abdominal distension 20.86 10.50 188 67243 58304 34831196
Overdose 20.51 10.50 98 67333 90961 34798539
Foetal exposure during pregnancy 20.50 10.50 26 67405 38075 34851425
White blood cell count decreased 20.32 10.50 277 67154 95168 34794332
Myelosuppression 20.23 10.50 6 67425 19259 34870241
Suicide attempt 19.71 10.50 28 67403 39088 34850412
Gangrene neonatal 19.69 10.50 9 67422 192 34889308
Spinal fracture 19.42 10.50 44 67387 7454 34882046
Skin turgor decreased 19.42 10.50 12 67419 479 34889021
Muscle spasticity 19.26 10.50 38 67393 5850 34883650
Premature baby 19.06 10.50 7 67424 19626 34869874
Paraneoplastic rash 18.76 10.50 7 67424 87 34889413
Decubitus ulcer 18.45 10.50 48 67383 8873 34880627
Metabolic encephalopathy 18.21 10.50 31 67400 4261 34885239
Pathological fracture 17.70 10.50 31 67400 4360 34885140
Haemorrhoids 17.60 10.50 65 67366 14510 34874990
Eosinophilia 17.36 10.50 15 67416 26207 34863293
Epilepsy 17.25 10.50 10 67421 21485 34868015
Pulmonary vasculitis 17.24 10.50 12 67419 587 34888913
Hypotension 17.21 10.50 554 66877 221095 34668405
Myasthenia gravis 17.18 10.50 40 67391 6900 34882600
Peritonitis bacterial 17.12 10.50 37 67394 6073 34883427
Hypoacusis 16.68 10.50 69 67362 16232 34873268
Anaphylactic shock 16.67 10.50 5 67426 15936 34873564
Neuropathy peripheral 16.65 10.50 239 67192 83024 34806476
Nausea 16.64 10.50 808 66623 339100 34550400
Neuritis 16.51 10.50 14 67417 920 34888580
Moaning 16.45 10.50 13 67418 773 34888727
Thrombosis 16.39 10.50 159 67272 50299 34839201
Hyporesponsive to stimuli 16.37 10.50 15 67416 1093 34888407
Metastatic renal cell carcinoma 16.29 10.50 20 67411 2041 34887459
Haematocrit decreased 16.14 10.50 112 67319 32104 34857396
Ageusia 16.00 10.50 50 67381 10258 34879242
Cellulitis 15.83 10.50 164 67267 52787 34836713
Gamma-glutamyltransferase increased 15.67 10.50 20 67411 29211 34860289
Inflammation 15.54 10.50 19 67412 28276 34861224
Urosepsis 15.39 10.50 57 67374 12742 34876758
Pleurothotonus 15.29 10.50 15 67416 1190 34888310
Oral pustule 14.92 10.50 8 67423 243 34889257
Disease progression 14.57 10.50 291 67140 107786 34781714
Appendicolith 14.55 10.50 43 67388 8558 34880942
Pulmonary embolism 14.31 10.50 248 67183 89498 34800002
Abdominal pain 14.30 10.50 415 67016 163203 34726297
Paratracheal lymphadenopathy 14.06 10.50 6 67425 108 34889392
Dry mouth 14.02 10.50 103 67328 30062 34859438
Cytomegalovirus infection 13.88 10.50 18 67413 26117 34863383
Metabolic acidosis 13.74 10.50 41 67390 43639 34845861
Synovitis 13.68 10.50 5 67426 14061 34875439
Dysphagia 13.66 10.50 182 67249 62199 34827301
Toxic epidermal necrolysis 13.59 10.50 13 67418 21633 34867867
Sitting disability 13.54 10.50 7 67424 197 34889303
Injection site pain 13.47 10.50 35 67396 38970 34850530
Accidental exposure to product 13.42 10.50 4 67427 12798 34876702
Hypervolaemia 13.31 10.50 74 67357 19635 34869865
Rib fracture 13.23 10.50 59 67372 14341 34875159
Intentional self-injury 13.22 10.50 5 67426 13766 34875734
Urinary retention 13.12 10.50 117 67314 36171 34853329
Product use issue 13.11 10.50 70 67361 63146 34826354
Eczema 12.88 10.50 10 67421 18426 34871074
Urinary incontinence 12.84 10.50 71 67360 18803 34870697
Weight decrease neonatal 12.69 10.50 8 67423 331 34889169
Wrong technique in product usage process 12.65 10.50 32 67399 35954 34853546
Myotonic dystrophy 12.52 10.50 6 67425 143 34889357
Maternal exposure during breast feeding 12.25 10.50 15 67416 1526 34887974
Contraindicated product administered 12.25 10.50 14 67417 21467 34868033
Cardiac failure congestive 12.17 10.50 227 67204 83043 34806457
Stress 12.10 10.50 100 67331 30247 34859253
Injection site reaction 12.07 10.50 5 67426 13028 34876472
Pain 12.06 10.50 496 66935 204179 34685321
Therapeutic response decreased 11.99 10.50 24 67407 29289 34860211
Product prescribing error 11.96 10.50 16 67415 22911 34866589
Neurogenic bladder 11.83 10.50 16 67415 1797 34887703
Body height decreased 11.61 10.50 24 67407 3819 34885681
Blood phosphorus increased 11.57 10.50 37 67394 7684 34881816
Muscle spasms 11.50 10.50 206 67225 74795 34814705
Muscular weakness 11.46 10.50 201 67230 72696 34816804
Incorrect dose administered 11.37 10.50 40 67391 40475 34849025
Blood potassium decreased 11.27 10.50 66 67365 17849 34871651
Oral pain 11.21 10.50 46 67385 10781 34878719
Decreased appetite 11.16 10.50 409 67022 165983 34723517
Bone marrow failure 11.08 10.50 25 67406 29228 34860272
Wrong patient received product 11.04 10.50 19 67412 2635 34886865
Band neutrophil percentage increased 10.97 10.50 5 67426 106 34889394
Dry skin 10.86 10.50 100 67331 31187 34858313
Chills 10.85 10.50 218 67213 80825 34808675
General physical health deterioration 10.84 10.50 178 67253 128091 34761409
Acute hepatic failure 10.66 10.50 7 67424 14067 34875433
Aortic aneurysm 10.63 10.50 33 67398 6746 34882754
Seizure like phenomena 10.62 10.50 10 67421 754 34888746
Drug therapy 10.55 10.50 12 67419 1129 34888371
Polyneuropathy 10.51 10.50 8 67423 14888 34874612

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Drug ineffective 384.64 9.52 795 135300 1080118 78528175
Constipation 384.22 9.52 1208 134887 281842 79326451
Completed suicide 233.70 9.52 65 136030 245702 79362591
Synovitis 215.00 9.52 10 136085 150724 79457569
Systemic lupus erythematosus 160.74 9.52 12 136083 121137 79487156
Hand deformity 154.62 9.52 5 136090 103914 79504379
Plasma cell myeloma 150.48 9.52 301 135794 52958 79555335
Pemphigus 143.99 9.52 6 136089 99576 79508717
Urinary tract infection 138.22 9.52 871 135224 273641 79334652
Mental status changes 137.61 9.52 333 135762 66626 79541667
Toxicity to various agents 129.69 9.52 334 135761 421206 79187087
Drug abuse 125.91 9.52 60 136035 162631 79445662
Off label use 125.48 9.52 971 135124 906244 78702049
Death 124.03 9.52 1494 134601 565020 79043273
Therapeutic product effect decreased 122.93 9.52 63 136032 163800 79444493
Pneumonia aspiration 121.86 9.52 318 135777 66649 79541644
Gastrooesophageal reflux disease 116.32 9.52 417 135678 103829 79504464
Arthropathy 108.34 9.52 86 136009 177025 79431268
Pulmonary embolism 106.00 9.52 575 135520 171079 79437214
Deep vein thrombosis 101.22 9.52 442 135653 120477 79487816
Pneumonia 97.31 9.52 1624 134471 658622 78949671
Duodenal ulcer perforation 92.45 9.52 5 136090 66206 79542087
Maternal exposure during pregnancy 91.72 9.52 60 136035 136478 79471815
Febrile neutropenia 91.35 9.52 691 135404 230308 79377985
Contraindicated product administered 90.81 9.52 81 136014 157457 79450836
Discomfort 90.25 9.52 51 136044 125566 79482727
Intentional overdose 88.44 9.52 35 136060 105925 79502368
Pericarditis 84.45 9.52 36 136059 104200 79504093
Treatment failure 83.23 9.52 101 135994 170385 79437908
Glossodynia 83.23 9.52 36 136059 103301 79504992
Failure to thrive 81.72 9.52 101 135994 11743 79596550
Hypoxia 80.10 9.52 369 135726 102874 79505419
Helicobacter infection 79.48 9.52 12 136083 69692 79538601
Joint swelling 78.84 9.52 242 135853 288404 79319889
C-reactive protein increased 78.46 9.52 63 136032 128964 79479329
Back pain 76.64 9.52 825 135270 303355 79304938
Salpingo-oophorectomy unilateral 72.16 9.52 33 136062 801 79607492
Drug intolerance 68.91 9.52 226 135869 263893 79344400
Folliculitis 66.79 9.52 8 136087 55372 79552921
Dehydration 66.66 9.52 682 135413 247505 79360788
Psoriatic arthropathy 66.35 9.52 25 136070 77974 79530319
Intestinal pseudo-obstruction 65.88 9.52 46 136049 2563 79605730
Condition aggravated 64.57 9.52 546 135549 500578 79107715
Muscle injury 63.86 9.52 5 136090 48556 79559737
Pleural effusion 62.80 9.52 444 135651 144818 79463475
Pulmonary malformation 62.70 9.52 21 136074 212 79608081
Drug interaction 62.59 9.52 433 135662 414750 79193543
Small intestinal obstruction 61.86 9.52 141 135954 27131 79581162
Asthenia 59.96 9.52 1215 134880 510474 79097819
Sleep disorder due to general medical condition, insomnia type 58.66 9.52 4 136091 43552 79564741
Respiratory symptom 56.12 9.52 54 136041 4737 79603556
Abdominal pain 55.65 9.52 954 135141 388615 79219678
Sinusitis fungal 55.65 9.52 40 136055 2334 79605959
Product use in unapproved indication 54.97 9.52 230 135865 250129 79358164
Hepatocellular injury 54.70 9.52 8 136087 47585 79560708
Therapeutic product effect incomplete 54.43 9.52 99 135996 141546 79466747
Fall 54.21 9.52 1149 134946 486480 79121813
Suicide attempt 53.61 9.52 38 136057 82894 79525399
Granulocytopenia 52.42 9.52 80 136015 11351 79596942
Alopecia 51.75 9.52 211 135884 231144 79377149
Irritable bowel syndrome 51.21 9.52 21 136074 62220 79546073
Drug resistance 51.15 9.52 6 136089 42207 79566086
Sepsis 50.88 9.52 692 135403 268736 79339557
Fatigue 48.92 9.52 1994 134101 927733 78680560
Vomiting 48.91 9.52 1484 134611 664344 78943949
Rheumatoid arthritis 48.61 9.52 187 135908 208283 79400010
Lung cyst 48.36 9.52 19 136076 312 79607981
Hospice care 46.98 9.52 72 136023 10252 79598041
Interstitial lung disease 46.65 9.52 75 136020 112525 79495768
Wound 46.63 9.52 79 136016 116100 79492193
General physical health deterioration 46.57 9.52 277 135818 274961 79333332
Peritonitis bacterial 45.35 9.52 68 136027 9499 79598794
Nausea 45.20 9.52 2030 134065 955166 78653127
Unresponsive to stimuli 45.19 9.52 202 135893 55586 79552707
Arthralgia 44.92 9.52 696 135399 571107 79037186
Hiatus hernia 44.77 9.52 113 135982 23199 79585094
Anti-neutrophil cytoplasmic antibody positive vasculitis 43.62 9.52 42 136053 3687 79604606
Myelosuppression 43.57 9.52 8 136087 40288 79568005
Hepatic enzyme increased 43.09 9.52 163 135932 182447 79425846
Sputum increased 43.08 9.52 46 136049 4567 79603726
Haemoglobin decreased 42.95 9.52 573 135522 221546 79386747
Oedema peripheral 42.82 9.52 636 135459 251652 79356641
Embolism venous 42.67 9.52 44 136051 4195 79604098
Disease progression 42.26 9.52 491 135604 183871 79424422
Hyponatraemia 41.81 9.52 476 135619 177372 79430921
Infection 41.56 9.52 242 135853 241470 79366823
Product use issue 40.53 9.52 202 135893 209620 79398673
Dyspnoea 40.52 9.52 1818 134277 855207 78753086
Hypersomnia 40.32 9.52 108 135987 22978 79585315
White blood cell count decreased 39.46 9.52 493 135602 187795 79420498
Diverticulum 38.30 9.52 81 136014 14815 79593478
Abdominal distension 38.13 9.52 341 135754 119309 79488984
Cellulitis 37.98 9.52 317 135778 108743 79499550
Diastolic dysfunction 37.86 9.52 67 136028 10744 79597549
Cestode infection 37.28 9.52 15 136080 263 79608030
Respiratory tract malformation 36.76 9.52 12 136083 111 79608182
Lethargy 36.60 9.52 251 135844 81041 79527252
Drug reaction with eosinophilia and systemic symptoms 35.85 9.52 34 136061 64210 79544083
Full blood count decreased 35.82 9.52 114 135981 26705 79581588
Temperature regulation disorder 35.78 9.52 47 136048 5806 79602487
Poor sucking reflex 35.67 9.52 12 136083 123 79608170
Hypervolaemia 35.66 9.52 156 135939 42534 79565759
Injection site reaction 35.54 9.52 25 136070 54760 79553533
Autonomic dysreflexia 33.42 9.52 16 136079 432 79607861
Somnolence 33.26 9.52 583 135512 238398 79369895
Inflammation 33.00 9.52 69 136026 93684 79514609
Exposure during pregnancy 32.68 9.52 78 136017 101054 79507239
Failure to suspend medication 32.56 9.52 16 136079 458 79607835
Proctalgia 32.50 9.52 60 136035 9941 79598352
Red blood cell sedimentation rate increased 32.49 9.52 19 136076 45923 79562370
Acute respiratory failure 32.46 9.52 193 135902 59348 79548945
Upper respiratory tract infection 32.28 9.52 266 135829 90902 79517391
Cholestasis 32.22 9.52 25 136070 52084 79556209
Liver injury 31.55 9.52 30 136065 56584 79551709
Impaired healing 31.28 9.52 64 136031 87591 79520702
Hypotension 31.08 9.52 977 135118 439340 79168953
Neutrophil count decreased 31.08 9.52 270 135825 93689 79514604
Haematocrit decreased 30.43 9.52 194 135901 61118 79547175
Swelling 30.19 9.52 231 135864 216480 79391813
Gastrointestinal disorder 30.19 9.52 107 135988 122098 79486195
Premenstrual syndrome 29.88 9.52 16 136079 550 79607743
Drug hypersensitivity 29.52 9.52 347 135748 298569 79309724
Female genital tract fistula 29.08 9.52 43 136052 5932 79602361
Total lung capacity decreased 28.97 9.52 30 136065 2875 79605418
Injection site erythema 28.85 9.52 56 136039 78141 79530152
Blood potassium decreased 28.80 9.52 156 135939 46356 79561937
Chest pain 28.69 9.52 657 135438 281647 79326646
Injection site pain 28.64 9.52 119 135976 129719 79478574
Fungal infection 28.59 9.52 144 135951 41604 79566689
Tricuspid valve incompetence 28.37 9.52 86 136009 19626 79588667
Emphysema 28.21 9.52 76 136019 16224 79592069
Maternal exposure during breast feeding 28.20 9.52 29 136066 2756 79605537
Confusional state 28.08 9.52 726 135369 317271 79291022
Fluid retention 27.64 9.52 209 135886 69600 79538693
Drug ineffective for unapproved indication 27.57 9.52 28 136067 51210 79557083
Abdominal discomfort 27.56 9.52 284 135811 250443 79357850
Hepatic function abnormal 27.28 9.52 52 136043 73055 79535238
Chronic sinusitis 26.98 9.52 65 136030 12961 79595332
Urticaria 26.95 9.52 195 135900 185006 79423287
Burkholderia test positive 26.64 9.52 15 136080 570 79607723
Anal inflammation 26.64 9.52 21 136074 1409 79606884
Cardiac failure congestive 26.54 9.52 365 135730 142037 79466256
Knee arthroplasty 26.42 9.52 21 136074 43227 79565066
Therapeutic response decreased 26.33 9.52 46 136049 66807 79541486
Hip fracture 26.14 9.52 113 135982 30648 79577645
Polymenorrhoea 26.08 9.52 18 136077 984 79607309
Decubitus ulcer 26.01 9.52 72 136023 15615 79592678
Magnesium deficiency 25.74 9.52 15 136080 609 79607684
Dysphagia 25.66 9.52 320 135775 121816 79486477
Blister 25.43 9.52 111 135984 119365 79488928
Lactation disorder 25.34 9.52 11 136084 235 79608058
Hysterectomy 24.77 9.52 41 136054 6231 79602062
Hallucination 24.61 9.52 239 135856 85506 79522787
Food allergy 24.59 9.52 56 136039 10768 79597525
Grip strength decreased 24.39 9.52 4 136091 21865 79586428
Bronchopulmonary aspergillosis allergic 24.24 9.52 28 136067 3033 79605260
Hypophagia 24.05 9.52 146 135949 45221 79563072
Haemorrhoids 23.99 9.52 106 135989 29022 79579271
Injection site swelling 23.97 9.52 27 136068 47105 79561188
Anaphylactic shock 23.91 9.52 16 136079 35980 79572313
Lichen sclerosus 23.88 9.52 17 136078 977 79607316
Exposure via breast milk 23.85 9.52 17 136078 979 79607314
Blood calcium increased 23.84 9.52 54 136041 10346 79597947
Intentional product use issue 23.68 9.52 157 135938 151955 79456338
Accidental exposure to product 23.53 9.52 12 136083 31310 79576983
Thrombosis 23.45 9.52 233 135862 83867 79524426
SARS-CoV-2 test negative 23.13 9.52 19 136076 1352 79606941
Lip pruritus 22.84 9.52 16 136079 896 79607397
Mobility decreased 22.80 9.52 119 135976 122056 79486237
Ill-defined disorder 22.75 9.52 49 136046 65826 79542467
Chest injury 22.67 9.52 26 136069 2795 79605498
Lung opacity 22.03 9.52 35 136060 5139 79603154
Platelet count decreased 21.98 9.52 460 135635 194204 79414089
Atrial fibrillation 21.50 9.52 465 135630 197421 79410872
Gastrointestinal haemorrhage 21.49 9.52 363 135732 147356 79460937
Nasal polyps 21.39 9.52 42 136053 7285 79601008
Product prescribing error 21.38 9.52 27 136068 44786 79563507
Urinary incontinence 21.27 9.52 131 135964 40778 79567515
Bone marrow failure 21.20 9.52 34 136061 51073 79557220
Abortion spontaneous 21.15 9.52 12 136083 29495 79578798
Cytokine release syndrome 21.12 9.52 119 135976 35879 79572414
Injection site pruritus 20.67 9.52 25 136070 42258 79566035
Renal impairment 20.67 9.52 171 135924 157612 79450681
Atelectasis 20.52 9.52 109 135986 32148 79576145
International normalised ratio increased 20.46 9.52 228 135867 84493 79523800
Menstruation delayed 20.45 9.52 18 136077 1408 79606885
Pneumonitis 20.18 9.52 175 135920 60685 79547608
Wrong technique in product usage process 20.09 9.52 62 136033 73813 79534480
Paraneoplastic rash 19.59 9.52 7 136088 87 79608206
Dental restoration failure 19.53 9.52 15 136080 969 79607324
Drug eruption 19.41 9.52 28 136067 43907 79564386
Red blood cell count decreased 19.40 9.52 166 135929 57347 79550946
Chronic obstructive pulmonary disease 19.33 9.52 227 135868 85192 79523101
Epistaxis 19.24 9.52 282 135813 111233 79497060
Epilepsy 19.10 9.52 25 136070 40835 79567458
Therapy non-responder 18.90 9.52 87 136008 92218 79516075
Poisoning 18.52 9.52 10 136085 25262 79583031
Foetal exposure timing unspecified 18.43 9.52 6 136089 55 79608238
Bone erosion 18.34 9.52 4 136091 17843 79590450
Adverse event 18.24 9.52 48 136047 60166 79548127
Fibromyalgia 18.21 9.52 53 136042 64287 79544006
Arthritis 18.17 9.52 118 135977 114762 79493531
Musculoskeletal stiffness 18.10 9.52 201 135894 174807 79433486
Appendicolith 18.06 9.52 43 136052 8508 79599785
Cytomegalovirus infection 18.04 9.52 28 136067 42616 79565677
Aspiration 17.86 9.52 75 136020 20083 79588210
Pregnancy 17.75 9.52 12 136083 26839 79581454
Excessive eye blinking 17.75 9.52 18 136077 1683 79606610
Metastatic renal cell carcinoma 17.74 9.52 21 136074 2334 79605959
Live birth 17.71 9.52 5 136090 18739 79589554
Blood phosphorus increased 17.66 9.52 48 136047 10299 79597994
Ascites 17.63 9.52 202 135893 75360 79532933
Hip arthroplasty 17.63 9.52 21 136074 35735 79572558
Respiratory failure 17.43 9.52 418 135677 180493 79427800
Toxic epidermal necrolysis 17.26 9.52 31 136064 44550 79563743
Obstructive airways disorder 17.16 9.52 102 135993 31357 79576936
Accident 17.16 9.52 43 136052 8788 79599505
Ecchymosis 17.09 9.52 61 136034 15145 79593148
Uterine perforation 17.05 9.52 35 136060 6268 79602025
Hypersensitivity 17.05 9.52 330 135765 261909 79346384
Accidental death 16.88 9.52 28 136067 4263 79604030
Sleep apnoea syndrome 16.63 9.52 113 135982 36365 79571928
Chills 16.60 9.52 374 135721 159860 79448433
Device expulsion 16.51 9.52 12 136083 25849 79582444
Lactic acidosis 16.45 9.52 63 136032 70296 79537997
Rash 16.45 9.52 813 135282 577545 79030748
Ileus 16.28 9.52 88 136007 26123 79582170
Overdose 16.24 9.52 219 135876 183987 79424306
Metabolic encephalopathy 16.18 9.52 43 136052 9104 79599189
Metabolic acidosis 16.18 9.52 79 136016 82450 79525843
Post procedural complication 16.18 9.52 82 136013 23747 79584546
Intentional self-injury 16.03 9.52 19 136076 32400 79575893
Decreased appetite 15.99 9.52 726 135369 341692 79266601
Pulmonary vasculitis 15.98 9.52 12 136083 749 79607544
Neuropathy peripheral 15.97 9.52 334 135761 140971 79467322
Iron deficiency anaemia 15.82 9.52 86 136009 25586 79582707
Dysmetropsia 15.71 9.52 6 136089 91 79608202
Painful respiration 15.60 9.52 24 136071 3429 79604864
Neuralgia 15.57 9.52 104 135991 33280 79575013
Calculus bladder 15.20 9.52 15 136080 1357 79606936
Drug-induced liver injury 14.95 9.52 60 136035 66057 79542236
Coeliac disease 14.93 9.52 48 136047 11303 79596990
Cholelithiasis 14.72 9.52 146 135949 52518 79555775
Myasthenia gravis 14.62 9.52 45 136050 10354 79597939
Hyperaesthesia 14.58 9.52 50 136045 12172 79596121
Colitis ulcerative 14.52 9.52 23 136072 34719 79573574
Hepatitis 14.29 9.52 48 136047 55679 79552614
Osteonecrosis of jaw 14.23 9.52 33 136062 43193 79565100
Cerebrovascular accident 14.11 9.52 356 135739 154936 79453357
Carbohydrate antigen 125 increased 14.07 9.52 18 136077 2166 79606127
Acute generalised exanthematous pustulosis 13.90 9.52 6 136089 17248 79591045
Intestinal obstruction 13.90 9.52 123 135972 42897 79565396
Rhabdomyolysis 13.85 9.52 111 135984 103020 79505273
Rubber sensitivity 13.85 9.52 16 136079 1733 79606560
Neuritis 13.78 9.52 16 136079 1742 79606551
Nasopharyngitis 13.74 9.52 329 135766 253552 79354741
Haemorrhage intracranial 13.70 9.52 84 136011 26109 79582184
Presyncope 13.58 9.52 118 135977 40936 79567357
Urinary retention 13.49 9.52 152 135943 56478 79551815
Duodenal stenosis 13.48 9.52 11 136084 776 79607517
Gamma-glutamyltransferase increased 13.42 9.52 48 136047 54632 79553661
Neurogenic bladder 13.35 9.52 25 136070 4187 79604106
Polyneuropathy 13.22 9.52 13 136082 24138 79584155
Anaemia 13.21 9.52 905 135190 444110 79164183
Pruritus 13.19 9.52 545 135550 394103 79214190
Drug tolerance decreased 13.15 9.52 3 136092 12975 79595318
Myotonic dystrophy 13.14 9.52 6 136089 145 79608148
Oral pain 13.03 9.52 96 135999 31702 79576591
Muscular weakness 13.03 9.52 363 135732 160366 79447927
Haemophagocytic lymphohistiocytosis 12.85 9.52 11 136084 21826 79586467
Labelled drug-drug interaction medication error 12.84 9.52 17 136078 27633 79580660
Noninfectious peritonitis 12.83 9.52 7 136088 250 79608043
Heparin-induced thrombocytopenia 12.79 9.52 41 136054 9641 79598652
Infusion related reaction 12.56 9.52 298 135797 229939 79378354
Walking aid user 12.53 9.52 42 136053 10106 79598187
Pathological fracture 12.47 9.52 43 136052 10494 79597799
Non-small cell lung cancer 12.39 9.52 31 136064 6329 79601964
Blood bilirubin decreased 12.37 9.52 12 136083 1063 79607230
Urinary tract obstruction 12.35 9.52 26 136069 4739 79603554
Posture abnormal 12.32 9.52 23 136072 3843 79604450
Cardiac failure 12.27 9.52 188 135907 154654 79453639
Oral pustule 12.25 9.52 7 136088 274 79608019
Iron deficiency 12.20 9.52 43 136052 10611 79597682
Injection site warmth 12.17 9.52 5 136090 14802 79593491
Liver disorder 12.16 9.52 73 136022 72344 79535949
Pneumonectomy 12.16 9.52 5 136090 93 79608200
Aspergillus infection 12.09 9.52 9 136086 19152 79589141
Nasal discharge discolouration 12.07 9.52 18 136077 2503 79605790
Multiple sclerosis 11.99 9.52 72 136023 22210 79586083
Airway burns 11.98 9.52 3 136092 9 79608284
Paratracheal lymphadenopathy 11.95 9.52 6 136089 180 79608113
Hypoacusis 11.78 9.52 90 136005 30060 79578233
Epiglottic erythema 11.72 9.52 4 136091 43 79608250
Impaired quality of life 11.60 9.52 5 136090 14381 79593912
Urinary retention postoperative 11.57 9.52 6 136089 193 79608100
Catheter site bruise 11.39 9.52 8 136087 450 79607843
Aortic aneurysm 11.37 9.52 36 136059 8410 79599883
Malignant neoplasm of thorax 11.32 9.52 3 136092 12 79608281
Spinal cord compression 11.30 9.52 30 136065 6347 79601946
Emotional distress 11.27 9.52 111 135984 39858 79568435
Dyspnoea exertional 11.24 9.52 210 135885 86863 79521430
Tuberculosis 11.16 9.52 6 136089 15192 79593101
Ageusia 11.13 9.52 57 136038 16575 79591718
Inguinal hernia 10.98 9.52 30 136065 6458 79601835
Delirium 10.89 9.52 204 135891 84423 79523870
Respiratory depression 10.89 9.52 19 136076 27611 79580682
Immunodeficiency 10.87 9.52 69 136026 21699 79586594
Musculoskeletal chest pain 10.87 9.52 76 136019 24688 79583605
Shock haemorrhagic 10.75 9.52 11 136084 20049 79588244
Heart rate increased 10.74 9.52 276 135819 120448 79487845
Injection site bruising 10.73 9.52 35 136060 40967 79567326
Blood test abnormal 10.69 9.52 59 136036 17651 79590642
Pleurothotonus 10.69 9.52 17 136078 2499 79605794
Circulatory collapse 10.68 9.52 31 136064 37637 79570656
Onychoclasis 10.67 9.52 27 136068 5551 79602742
Therapeutic response shortened 10.61 9.52 7 136088 15856 79592437
Tremor 10.58 9.52 372 135723 169711 79438582
Eosinophil count decreased 10.57 9.52 20 136075 3376 79604917
Pneumonia viral 10.52 9.52 37 136058 9121 79599172
Perirectal abscess 10.39 9.52 15 136080 2026 79606267
Impaired work ability 10.31 9.52 11 136084 19670 79588623
Urosepsis 10.30 9.52 79 136016 26416 79581877
Diabetes mellitus inadequate control 10.20 9.52 16 136079 24248 79584045
Catheter site pain 10.20 9.52 26 136069 5370 79602923
Hepatotoxicity 10.16 9.52 49 136046 51303 79556990
Sexually inappropriate behaviour 10.15 9.52 8 136087 537 79607756
Coma 10.13 9.52 234 135861 100415 79507878
Pulmonary hypertension 10.10 9.52 126 135969 47954 79560339
Sitting disability 10.02 9.52 7 136088 390 79607903
Phlebosclerosis 10.02 9.52 5 136090 148 79608145
Abdominal mass 9.96 9.52 20 136075 3525 79604768
Seizure like phenomena 9.91 9.52 14 136081 1853 79606440
Type 2 diabetes mellitus 9.90 9.52 57 136038 57065 79551228
Dry skin 9.85 9.52 167 135928 67828 79540465
Convulsive threshold lowered 9.84 9.52 10 136085 937 79607356
Sleep disorder 9.84 9.52 96 135999 85581 79522712
Hospitalisation 9.77 9.52 220 135875 94016 79514277
Non-cardiac chest pain 9.69 9.52 37 136058 9487 79598806
Gastrointestinal arteriovenous malformation 9.66 9.52 10 136085 958 79607335
Oesophageal ulcer 9.64 9.52 30 136065 6945 79601348
Drooling 9.61 9.52 27 136068 5907 79602386
Blood loss anaemia 9.60 9.52 52 136043 15446 79592847
Depressed level of consciousness 9.60 9.52 112 135983 96540 79511753
Anal injury 9.58 9.52 5 136090 163 79608130
Intentional product misuse 9.56 9.52 110 135985 95055 79513238
Posterior reversible encephalopathy syndrome 9.54 9.52 19 136076 26262 79582031
Drug therapy 9.53 9.52 11 136084 1190 79607103

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
ATC A06AA02 ALIMENTARY TRACT AND METABOLISM
DRUGS FOR CONSTIPATION
DRUGS FOR CONSTIPATION
Softeners, emollients
ATC A06AG10 ALIMENTARY TRACT AND METABOLISM
DRUGS FOR CONSTIPATION
DRUGS FOR CONSTIPATION
Enemas
MeSH PA D013501 Surface-Active Agents

Drug Use | Suggest Off label Use Form| |View source of the data|

DiseaseRelationSNOMED_IDDOID
Constipation indication 14760008 DOID:2089
Megaloblastic anemia due to folate deficiency indication 85649008 DOID:14026
Iron deficiency anemia indication 87522002
Pregnancy, function indication 289908002
Breastfeeding (mother) indication 413712001
Incomplete passage of stool off-label use 249515001
Prevention of Fetal Neural Tube Defects during Pregnancy off-label use
Peptic ulcer contraindication 13200003 DOID:750
Primary hyperoxaluria contraindication 17901006 DOID:2977
Gastroenteritis contraindication 25374005 DOID:2326
Hemosiderosis contraindication 39011001 DOID:12119
Hypokalemia contraindication 43339004
Bleeding hemorrhoids contraindication 51551000
Gastrectomy contraindication 53442002
Leber's optic atrophy contraindication 58610003 DOID:705
Hemolytic anemia contraindication 61261009 DOID:583
Ulcerative colitis contraindication 64766004 DOID:8577
Incontinence of feces contraindication 72042002
Appendicitis contraindication 74400008 DOID:8337
Atrophic gastritis contraindication 84568007 DOID:8929
Disorder of mucous membrane contraindication 95351003
Anemia due to enzyme deficiency contraindication 111577008
Gastrointestinal obstruction contraindication 126765001
Hb SS disease contraindication 127040003 DOID:10923
Urinary incontinence contraindication 165232002
Diverticular disease contraindication 397881000
Hemochromatosis contraindication 399187006 DOID:2352
Repeated Blood Transfusions contraindication




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 12.0 acidic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

None

External reference:

IDSource
4019731 VUID
N0000179792 NUI
D03885 KEGG_DRUG
128-49-4 SECONDARY_CAS_RN
71722 RXNORM
4017673 VANDF
4019248 VANDF
4019731 VANDF
C0243237 UMLSCUI
CHEBI:4674 CHEBI
CHEMBL1905872 ChEMBL_ID
CHEMBL1477036 ChEMBL_ID
CHEMBL2106608 ChEMBL_ID
531 INN_ID
F05Q2T2JA0 UNII
23673837 PUBCHEM_CID
DB11089 DRUGBANK_ID
29340 MMSL
4627 MMSL
4629 MMSL
6142 MMSL
6143 MMSL
NOCODE MMSL
d01021 MMSL
001180 NDDF
001181 NDDF
001183 NDDF
116528004 SNOMEDCT_US
387088007 SNOMEDCT_US
418528006 SNOMEDCT_US
418700002 SNOMEDCT_US
D004143 MESH_DESCRIPTOR_UI
577-11-7 SECONDARY_CAS_RN

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
good sense stool softener HUMAN OTC DRUG LABEL 1 0113-0486 CAPSULE, LIQUID FILLED 100 mg ORAL OTC monograph not final 15 sections
basic care stool softener HUMAN OTC DRUG LABEL 1 0113-7004 CAPSULE, LIQUID FILLED 100 mg ORAL OTC monograph not final 15 sections
Docusate Sodium HUMAN OTC DRUG LABEL 1 0121-0544 LIQUID 50 mg ORAL OTC monograph not final 15 sections
Docusate Sodium HUMAN OTC DRUG LABEL 1 0121-0935 LIQUID 50 mg ORAL OTC monograph not final 15 sections
Docusate Sodium HUMAN OTC DRUG LABEL 1 0121-1870 LIQUID 100 mg ORAL OTC monograph not final 15 sections
Pedia-Lax HUMAN OTC DRUG LABEL 1 0132-0106 LIQUID 50 mg ORAL OTC monograph not final 10 sections
Pedia-Lax HUMAN OTC DRUG LABEL 1 0132-0107 LIQUID 50 mg ORAL OTC monograph not final 13 sections
Ferralet 90 HUMAN PRESCRIPTION DRUG LABEL 5 0178-0089 TABLET, FILM COATED 50 mg ORAL unapproved drug other 17 sections
Ferralet 90 HUMAN PRESCRIPTION DRUG LABEL 5 0178-0089 TABLET, FILM COATED 50 mg ORAL unapproved drug other 17 sections
CitraNatal Harmony 3.0 HUMAN PRESCRIPTION DRUG LABEL 8 0178-0796 CAPSULE, GELATIN COATED 50 mg ORAL unapproved drug other 10 sections
CitraNatal Harmony 3.0 HUMAN PRESCRIPTION DRUG LABEL 8 0178-0796 CAPSULE, GELATIN COATED 50 mg ORAL unapproved drug other 10 sections
CitraNatal Harmony HUMAN PRESCRIPTION DRUG LABEL 8 0178-0798 CAPSULE, GELATIN COATED 50 mg ORAL UNAPPROVED DRUG OTHER 11 sections
CitraNatal Harmony HUMAN PRESCRIPTION DRUG LABEL 8 0178-0799 CAPSULE, GELATIN COATED 50 mg ORAL Unapproved drug other 11 sections
CitraNatal Harmony HUMAN PRESCRIPTION DRUG LABEL 8 0178-0812 CAPSULE, GELATIN COATED 50 mg ORAL Unapproved drug other 11 sections
CitraNatal Bloom HUMAN PRESCRIPTION DRUG LABEL 6 0178-0813 TABLET, FILM COATED 55 mg ORAL unapproved drug other 15 sections
CitraNatal Bloom HUMAN PRESCRIPTION DRUG LABEL 6 0178-0813 TABLET, FILM COATED 55 mg ORAL unapproved drug other 15 sections
CitraNatal Bloom HUMAN PRESCRIPTION DRUG LABEL 6 0178-0813 TABLET, FILM COATED 55 mg ORAL unapproved drug other 15 sections
CitraNatal 90 DHA HUMAN PRESCRIPTION DRUG LABEL 16 0178-0821 TABLET 50 mg ORAL unapproved drug other 11 sections
CitraNatal 90 DHA HUMAN PRESCRIPTION DRUG LABEL 16 0178-0821 TABLET 50 mg ORAL unapproved drug other 11 sections
CitraNatal 90 DHA HUMAN OTC DRUG LABEL 14 0178-0829 TABLET 50 mg ORAL Unapproved drug other 11 sections
CitraNatal Rx HUMAN PRESCRIPTION DRUG LABEL 14 0178-0859 TABLET 50 mg ORAL Unapproved drug other 9 sections
CitraNatal DHA HUMAN OTC DRUG LABEL 14 0178-0898 TABLET 50 mg ORAL Unapproved drug other 11 sections
Phillips Stool SoftenerBulk Docusate HUMAN OTC DRUG LABEL 1 0280-1012 CAPSULE, LIQUID FILLED 100 mg ORAL OTC monograph not final 15 sections
Phillips Stool SoftenerBulk Docusate HUMAN OTC DRUG LABEL 1 0280-1012 CAPSULE, LIQUID FILLED 100 mg ORAL OTC monograph not final 15 sections
Phillips Stool SoftenerBulk Docusate HUMAN OTC DRUG LABEL 1 0280-1012 CAPSULE, LIQUID FILLED 100 mg ORAL OTC monograph not final 15 sections
Phillips Stool SoftenerBulk Docusate HUMAN OTC DRUG LABEL 1 0280-1012 CAPSULE, LIQUID FILLED 100 mg ORAL OTC monograph not final 15 sections
Stool Softener Laxative HUMAN OTC DRUG LABEL 1 0363-0016 CAPSULE, LIQUID FILLED 100 mg ORAL OTC MONOGRAPH NOT FINAL 14 sections
Stool Softener HUMAN OTC DRUG LABEL 1 0363-0257 CAPSULE, LIQUID FILLED 240 mg ORAL OTC monograph not final 14 sections
Stool SoftenerPlus Stimulant Laxative HUMAN OTC DRUG LABEL 2 0363-0584 TABLET 50 mg ORAL OTC MONOGRAPH NOT FINAL 14 sections
Stool SoftenerPlus Stimulant Laxative HUMAN OTC DRUG LABEL 2 0363-0584 TABLET 50 mg ORAL OTC MONOGRAPH NOT FINAL 14 sections