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dextromoramide 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | PK/Tox | Related Drugs | BioActivity |
| Stem definition | Drug id | CAS RN |
|---|---|---|
| 843 | 357-56-2 |
Description:
| Molecule | Description |
|---|---|
|
Synonyms:
|
An opioid analgesic structurally related to METHADONE and used in the treatment of severe pain. (From Martindale, The Extra Pharmacopoeia, 30th ed, p1070)
|
Drug dosage:
| Dose | Unit | Route |
|---|---|---|
| 20 | mg | O |
| 20 | mg | P |
| 40 | mg | R |
ADMET properties:
| Property | Value | Reference |
|---|---|---|
| BA (Bioavailability) | 99 % | Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H |
| Vd (Volume of distribution) | 0.47 L/kg | Lombardo F, Berellini G, Obach RS |
| CL (Clearance) | 2.19 mL/min/kg | Lombardo F, Berellini G, Obach RS |
| t_half (Half-life) | 3.18 hours | Lombardo F, Berellini G, Obach RS |
Predicted pharmacokinetic/toxicological properties (PK-AZ):
| Property | Description | Value | Unit | Confidence | Similarity |
|---|---|---|---|---|---|
| kinase-safety-class | ACVR2B,AXL,BRAF,CAMK2D,CDK5,CDK9,EIF2AK3,EPHB4,ERBB2,GRK2,ITK,MAPK7,MAPKAPK2,NTRK2,PDK4,PRKDC,SIK3 | 17 | |||
| kinase-selectivity-class | AXL,GRK2,PDK4 | 3 | |||
| pfas-class | PFAS structural alert (1 = True, 0 = False) | 0 |
Approvals:
None
FDA Adverse Event Reporting System (Female)
None
FDA Adverse Event Reporting System (Male)
None
FDA Adverse Event Reporting System (Geriatric)
None
FDA Adverse Event Reporting System (Pediatric)
None
Pharmacologic Action:
| Source | Code | Description |
|---|---|---|
| ATC | N02AC01 | NERVOUS SYSTEM ANALGESICS OPIOIDS Diphenylpropylamine derivatives |
| MeSH PA | D000700 | Analgesics |
| MeSH PA | D000701 | Analgesics, Opioid |
| MeSH PA | D002492 | Central Nervous System Depressants |
| MeSH PA | D009294 | Narcotics |
| MeSH PA | D018689 | Sensory System Agents |
| CHEBI has role | CHEBI:35482 | opioid analgesic |
Related Drugs by ATC class:
N02AC Diphenylpropylamine derivatives 4 drugs
Drug Use | Suggest Off label Use Form| |View source of the data|
| Disease | Relation | SNOMED_ID | DOID |
|---|---|---|---|
| Severe pain | indication | 76948002 |
🐶 Veterinary Drug Use
None
🐶 Veterinary products
None
Acid dissociation constants calculated using MoKa v3.0.0
| Dissociation level | Dissociation constant | Type (acidic/basic) |
|---|---|---|
| pKa1 | 6.5 | Basic |
Orange Book patent data (new drug applications)
None
Orange Book exclusivity data (new drug applications)
None
Bioactivity Summary:
None
External reference:
| ID | Source |
|---|---|
| N0000167041 | NUI |
| D07287 | KEGG_DRUG |
| 104959 | RXNORM |
| C0011817 | UMLSCUI |
| CHEBI:74274 | CHEBI |
| CHEMBL3833389 | ChEMBL_ID |
| D003916 | MESH_DESCRIPTOR_UI |
| DB01529 | DRUGBANK_ID |
| 92943 | PUBCHEM_CID |
| 733 | INN_ID |
| 2922-44-3 | SECONDARY_CAS_RN |
| 9S4S6CIY83 | UNII |
| 003694 | NDDF |
| 003695 | NDDF |
| 322508000 | SNOMEDCT_US |
| 387561007 | SNOMEDCT_US |
| 96191003 | SNOMEDCT_US |
| CHEMBL3833311 | ChEMBL_ID |
| 9S4S6CIY83 | INXIGHT DRUGS |
Pharmaceutical products:
None