piritramide 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definition	Drug id	CAS RN
	3478	302-41-0

Description:

Molecule

Description

Molfile Inchi Smiles

Synonyms:

piritramide
dipidolor
dipiritramide
pirdolan
piridolan
pirinitramide

A diphenylpropylamine with intense narcotic analgesic activity of long duration. It is a derivative of MEPERIDINE with similar activity and usage.

Molecular weight: 430.60
Formula: C27H34N4O
CLOGP: 3.19
LIPINSKI: 0
HAC: 5
HDO: 1
TPSA: 73.36
ALOGS: -4.63
ROTB: 7

Drug dosage:

Dose	Unit	Route
45	mg	P

ADMET properties:

Property	Value	Reference
Vd (Volume of distribution)	4.70 L/kg	Lombardo F, Berellini G, Obach RS
CL (Clearance)	7.80 mL/min/kg	Lombardo F, Berellini G, Obach RS
fu (Fraction unbound in plasma)	0.06 %	Lombardo F, Berellini G, Obach RS
t_half (Half-life)	8 hours	Lombardo F, Berellini G, Obach RS

Approvals:

None

FDA Adverse Event Reporting System (Female)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Toxic epidermal necrolysis	83.40	35.14	31	1974	25303	63461714
Basal ganglion degeneration	68.97	35.14	12	1993	436	63486581
Patent ductus arteriosus	65.51	35.14	17	1988	4233	63482784
Tissue infiltration	64.90	35.14	12	1993	617	63486400
Anaesthesia	62.59	35.14	11	1994	424	63486593
Uterine enlargement	56.51	35.14	12	1993	1256	63485761
Stevens-Johnson syndrome	55.51	35.14	23	1982	24927	63462090
Congenital central hypoventilation syndrome	54.09	35.14	7	1998	29	63486988
Psychogenic seizure	53.06	35.14	12	1993	1680	63485337
Inguinal hernia	51.02	35.14	12	1993	1995	63485022
Renal cyst	50.65	35.14	17	1988	10285	63476732
Neurological decompensation	47.76	35.14	12	1993	2626	63484391
Monoplegia	45.46	35.14	12	1993	3189	63483828
Dysaesthesia	41.47	35.14	12	1993	4466	63482551
Hypochromic anaemia	41.03	35.14	10	1995	1932	63485085
Abdominal tenderness	38.26	35.14	13	1992	8153	63478864
Intervertebral disc disorder	36.21	35.14	11	1994	4832	63482185

FDA Adverse Event Reporting System (Male)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Blood pressure measurement	91.90	45.62	13	784	167	34955967
Weight bearing difficulty	68.45	45.62	13	784	1082	34955052
Hyperventilation	56.17	45.62	13	784	2811	34953323
Oropharyngeal discomfort	54.57	45.62	13	784	3183	34952951

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Hyperventilation	79.03	35.35	22	2262	7877	79734227
Blood pressure measurement	76.88	35.35	13	2271	440	79741664
Basal ganglion degeneration	63.33	35.35	11	2273	437	79741667
Toxic epidermal necrolysis	59.89	35.35	28	2256	44553	79697551
Tissue infiltration	58.57	35.35	11	2273	680	79741424
Uterine enlargement	55.57	35.35	11	2273	897	79741207
Anaesthesia	55.00	35.35	10	2274	517	79741587
Congenital central hypoventilation syndrome	54.77	35.35	7	2277	29	79742075
Stevens-Johnson syndrome	53.85	35.35	25	2259	39141	79702963
Weight bearing difficulty	51.46	35.35	13	2271	3208	79738896
Psychogenic seizure	47.30	35.35	11	2273	1920	79740184
Speech disorder	43.28	35.35	24	2260	54421	79687683
Inguinal hernia	42.44	35.35	13	2271	6475	79735629
Oropharyngeal discomfort	41.17	35.35	13	2271	7153	79734951
Cardiovascular disorder	39.51	35.35	16	2268	18009	79724095
Monoplegia	39.43	35.35	11	2273	3960	79738144
Hypochromic anaemia	38.54	35.35	10	2274	2741	79739363
Neurological decompensation	36.39	35.35	11	2273	5242	79736862

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

Source	Code	Description
ATC	N02AC03	NERVOUS SYSTEM ANALGESICS OPIOIDS Diphenylpropylamine derivatives
MeSH PA	D000700	Analgesics
MeSH PA	D000701	Analgesics, Opioid
MeSH PA	D002491	Central Nervous System Agents
MeSH PA	D002492	Central Nervous System Depressants
MeSH PA	D009294	Narcotics
MeSH PA	D018373	Peripheral Nervous System Agents
MeSH PA	D018689	Sensory System Agents

Drug Use | Suggest Off label Use Form| |View source of the data|

None

🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation level	Dissociation constant	Type (acidic/basic)
pKa1	8.07	Basic
pKa2	6.0	Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

None

External reference:

ID	Source
N0000167338	NUI
D07288	KEGG_DRUG
C0031982	UMLSCUI
CHEBI:135699	CHEBI
CHEMBL559288	ChEMBL_ID
DB12492	DRUGBANK_ID
9331	PUBCHEM_CID
1343	INN_ID
4RP92LYZ2F	UNII
8354	RXNORM
006892	NDDF
707837002	SNOMEDCT_US
D010892	MESH_DESCRIPTOR_UI

Pharmaceutical products:

None