piritramide 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |
| Stem definition | Drug id | CAS RN |
|---|---|---|
| 3478 | 302-41-0 |
Description:
| Molecule | Description |
|---|---|
|
Synonyms:
|
A diphenylpropylamine with intense narcotic analgesic activity of long duration. It is a derivative of MEPERIDINE with similar activity and usage.
|
Drug dosage:
| Dose | Unit | Route |
|---|---|---|
| 45 | mg | P |
ADMET properties:
| Property | Value | Reference |
|---|---|---|
| Vd (Volume of distribution) | 4.70 L/kg | Lombardo F, Berellini G, Obach RS |
| CL (Clearance) | 7.80 mL/min/kg | Lombardo F, Berellini G, Obach RS |
| fu (Fraction unbound in plasma) | 0.06 % | Lombardo F, Berellini G, Obach RS |
| t_half (Half-life) | 8 hours | Lombardo F, Berellini G, Obach RS |
Approvals:
None
FDA Adverse Event Reporting System (Female)
| MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
|---|---|---|---|---|---|---|
| Patent ductus arteriosus | 70.30 | 42.75 | 17 | 1325 | 3803 | 50599979 |
| Basal ganglion degeneration | 65.22 | 42.75 | 11 | 1331 | 397 | 50603385 |
| Tissue infiltration | 61.88 | 42.75 | 11 | 1331 | 542 | 50603240 |
| Anaesthesia | 59.59 | 42.75 | 10 | 1332 | 350 | 50603432 |
| Congenital central hypoventilation syndrome | 55.32 | 42.75 | 7 | 1335 | 29 | 50603753 |
| Uterine enlargement | 54.68 | 42.75 | 11 | 1331 | 1055 | 50602727 |
| Psychogenic seizure | 50.33 | 42.75 | 11 | 1331 | 1574 | 50602208 |
| Inguinal hernia | 49.52 | 42.75 | 11 | 1331 | 1695 | 50602087 |
| Neurological decompensation | 46.39 | 42.75 | 11 | 1331 | 2259 | 50601523 |
| Monoplegia | 44.17 | 42.75 | 11 | 1331 | 2772 | 50601010 |
FDA Adverse Event Reporting System (Male)
| MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
|---|---|---|---|---|---|---|
| Blood pressure measurement | 91.50 | 53.86 | 13 | 707 | 161 | 29573646 |
| Weight bearing difficulty | 70.58 | 53.86 | 13 | 707 | 858 | 29572949 |
| Hyperventilation | 57.65 | 53.86 | 13 | 707 | 2349 | 29571458 |
| Oropharyngeal discomfort | 56.62 | 53.86 | 13 | 707 | 2543 | 29571264 |
FDA Adverse Event Reporting System (Geriatric)
| MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
|---|---|---|---|---|---|---|
| Blood pressure measurement | 77.58 | 36.21 | 13 | 1989 | 383 | 64496347 |
| Hyperventilation | 75.80 | 36.21 | 21 | 1981 | 6819 | 64489911 |
| Basal ganglion degeneration | 56.75 | 36.21 | 10 | 1992 | 398 | 64496332 |
| Congenital central hypoventilation syndrome | 54.21 | 36.21 | 7 | 1995 | 29 | 64496701 |
| Tissue infiltration | 53.02 | 36.21 | 10 | 1992 | 583 | 64496147 |
| Weight bearing difficulty | 52.69 | 36.21 | 13 | 1989 | 2690 | 64494040 |
| Uterine enlargement | 50.27 | 36.21 | 10 | 1992 | 771 | 64495959 |
| Anaesthesia | 49.89 | 36.21 | 9 | 1993 | 410 | 64496320 |
| Oropharyngeal discomfort | 43.93 | 36.21 | 13 | 1989 | 5322 | 64491408 |
| Psychogenic seizure | 41.73 | 36.21 | 10 | 1992 | 1831 | 64494899 |
| Speech disorder | 41.36 | 36.21 | 23 | 1979 | 48418 | 64448312 |
| Cardiovascular disorder | 40.23 | 36.21 | 16 | 1986 | 15865 | 64480865 |
FDA Adverse Event Reporting System (Pediatric)
None
Pharmacologic Action:
| Source | Code | Description |
|---|---|---|
| ATC | N02AC03 | NERVOUS SYSTEM ANALGESICS OPIOIDS Diphenylpropylamine derivatives |
| MeSH PA | D000700 | Analgesics |
| MeSH PA | D000701 | Analgesics, Opioid |
| MeSH PA | D002491 | Central Nervous System Agents |
| MeSH PA | D002492 | Central Nervous System Depressants |
| MeSH PA | D009294 | Narcotics |
| MeSH PA | D018373 | Peripheral Nervous System Agents |
| MeSH PA | D018689 | Sensory System Agents |
Drug Use | Suggest Off label Use Form| |View source of the data|
None
🐶 Veterinary Drug Use
None
🐶 Veterinary products
None
Acid dissociation constants calculated using MoKa v3.0.0
| Dissociation level | Dissociation constant | Type (acidic/basic) |
|---|---|---|
| pKa1 | 8.07 | Basic |
| pKa2 | 6.0 | Basic |
Orange Book patent data (new drug applications)
None
Orange Book exclusivity data (new drug applications)
None
Bioactivity Summary:
None
External reference:
| ID | Source |
|---|---|
| N0000167338 | NUI |
| D07288 | KEGG_DRUG |
| C0031982 | UMLSCUI |
| CHEBI:135699 | CHEBI |
| CHEMBL559288 | ChEMBL_ID |
| DB12492 | DRUGBANK_ID |
| 9331 | PUBCHEM_CID |
| 1343 | INN_ID |
| 4RP92LYZ2F | UNII |
| 8354 | RXNORM |
| 006892 | NDDF |
| 707837002 | SNOMEDCT_US |
| D010892 | MESH_DESCRIPTOR_UI |
Pharmaceutical products:
None