methadone ๐Ÿถ Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | PK/Tox | Related Drugs | BioActivity |

Stem definitionDrug idCAS RN
1728 76-99-3

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • metadone
  • methadone
  • methadone hydrochloride
  • methadone HCl
A synthetic opioid that is used as the hydrochloride. It is an opioid analgesic that is primarily a mu-opioid agonist. It has actions and uses similar to those of MORPHINE. (From Martindale, The Extra Pharmacopoeia, 30th ed, p1082-3)
  • Molecular weight: 309.45
  • Formula: C21H27NO
  • CLOGP: 4.17
  • LIPINSKI: 0
  • HAC: 2
  • HDO: 0
  • TPSA: 20.31
  • ALOGS: -4.72
  • ROTB: 7
  • Status: OFP
    • Legend:
    OFP - off patent
    OFM - off market
    ONP - on patent

Drug dosage:

DoseUnitRoute
25 mg O
25 mg P

ADMET properties:

PropertyValueReference
BDDCS (Biopharmaceutical Drug Disposition Classification System) 1 Benet LZ, Broccatelli F, Oprea TI
S (Water solubility) 120 mg/mL Benet LZ, Broccatelli F, Oprea TI
EoM (Fraction excreted unchanged in urine) 24 % Benet LZ, Broccatelli F, Oprea TI
MRTD (Maximum Recommended Therapeutic Daily Dose) 1.62 ยตM/kg/day Contrera JF, Matthews EJ, Kruhlak NL, Benz RD
BA (Bioavailability) 92 % Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H
Vd (Volume of distribution) 4.40 L/kg Lombardo F, Berellini G, Obach RS
CL (Clearance) 1.70 mL/min/kg Lombardo F, Berellini G, Obach RS
fu (Fraction unbound in plasma) 0.21 % Lombardo F, Berellini G, Obach RS
t_half (Half-life) 31 hours Lombardo F, Berellini G, Obach RS

Predicted pharmacokinetic/toxicological properties (PK-AZ):

PropertyDescriptionValueUnitConfidenceSimilarity
kinase-safety-class ACVR2B,AKT1,AKT2,AKT3,AXL,BRAF,BTK,CAMK2B,CAMK2D,CDK4,CDK5,CDK9,EIF2AK3,EPHB4,ERBB2,GRK2,ITK,JAK2,JAK3,MAP3K7,MAPK10,MAPK12,MAPK7,MET,NTRK2,PDK2,PDK4,PDPK1,PIM2,PRKDC,SIK2,TEK,TGFBR1 33
kinase-selectivity-class AXL,EIF2AK3,GRK2,PDK4,SIK2 5
pfas-class PFAS structural alert (1 = True, 0 = False) 0

Approvals:

DateAgencyCompanyOrphan
Aug. 13, 1947 FDA ROXANE

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Drug abuse 3442.43 13.00 1275 34934 81072 90511166
Toxicity to various agents 2444.89 13.00 1481 34728 286365 90305873
Completed suicide 801.51 13.00 573 35636 144485 90447753
Death 679.75 13.00 871 35338 455680 90136558
Exposure during pregnancy 648.02 13.00 624 35585 237786 90354452
Cardio-respiratory arrest 613.09 13.00 356 35853 62784 90529454
Respiratory depression 581.98 13.00 223 35986 15352 90576886
Respiratory arrest 532.90 13.00 262 35947 33049 90559189
Drug withdrawal syndrome 471.64 13.00 230 35979 28493 90563745
Cardiac arrest 427.46 13.00 346 35863 104589 90487649
Torsade de pointes 370.00 13.00 160 36049 15022 90577216
Premature delivery 369.27 13.00 216 35993 38546 90553692
Drug dependence 365.51 13.00 195 36014 29132 90563106
Poisoning 346.88 13.00 153 36056 15064 90577174
Electrocardiogram QT prolonged 329.47 13.00 255 35954 72201 90520037
Overdose 322.93 13.00 355 35854 157354 90434884
Intentional product misuse 316.15 13.00 272 35937 89332 90502906
Depressed level of consciousness 289.91 13.00 237 35972 72547 90519691
Premature labour 277.74 13.00 126 36083 13250 90578988
Withdrawal syndrome 272.88 13.00 147 36062 22377 90569861
Drug interaction 232.88 13.00 405 35804 276048 90316190
Miosis 214.97 13.00 95 36114 9389 90582849
Drug withdrawal syndrome neonatal 208.04 13.00 64 36145 2255 90589983
Accidental overdose 204 13.00 132 36077 28141 90564097
Coma 198.29 13.00 191 36018 72441 90519797
Hyperaesthesia 197.79 13.00 93 36116 10609 90581629
Somnolence 166.46 13.00 299 35910 208785 90383453
Substance use disorder 165.46 13.00 52 36157 1968 90590270
Drug use disorder 165.04 13.00 76 36133 8267 90583971
Asphyxia 160.50 13.00 71 36138 7032 90585206
Unresponsive to stimuli 159.88 13.00 128 36081 37993 90554245
Substance abuse 155.10 13.00 64 36145 5342 90586896
Sedation 149.36 13.00 136 36073 48035 90544203
Substance use 137.50 13.00 40 36169 1159 90591079
Bradypnoea 129.76 13.00 54 36155 4604 90587634
Drug diversion 124.82 13.00 36 36173 1011 90591227
Accidental exposure to product by child 120.47 13.00 37 36172 1296 90590942
Systemic lupus erythematosus 113.69 13.00 8 36201 361888 90230350
Exposure via ingestion 113.40 13.00 42 36167 2625 90589613
Glossodynia 107.54 13.00 5 36204 321774 90270464
Toxic leukoencephalopathy 104.68 13.00 30 36179 823 90591415
Hand deformity 104.56 13.00 3 36206 296359 90295879
Synovitis 93.64 13.00 11 36198 329741 90262497
Infusion related reaction 87.09 13.00 29 36180 416751 90175487
Abdominal discomfort 85.47 13.00 42 36167 477286 90114952
Wound 83.84 13.00 11 36198 302969 90289269
Arthropathy 82.85 13.00 22 36187 366220 90226018
Maternal exposure during pregnancy 82.56 13.00 323 35886 359740 90232498
Alopecia 82.14 13.00 48 36161 495023 90097215
Pericarditis 81.93 13.00 7 36202 270144 90322094
Agitation 77.93 13.00 114 36095 66984 90525254
Rash 77.79 13.00 124 36085 795976 89796262
Catatonia 77.47 13.00 41 36168 6015 90586223
Drug intolerance 76.24 13.00 42 36167 447549 90144689
Leukoencephalopathy 73.92 13.00 37 36172 4836 90587402
Mental status changes 73.52 13.00 90 36119 44589 90547649
Discomfort 73.45 13.00 11 36198 274324 90317914
Accidental poisoning 71.55 13.00 23 36186 937 90591301
Joint swelling 71.26 13.00 58 36151 503242 90088996
Foetal exposure during pregnancy 69.80 13.00 86 36123 42889 90549349
Rheumatoid arthritis 69.41 13.00 29 36180 362585 90229653
Urticaria 66.65 13.00 21 36188 312713 90279525
Psoriatic arthropathy 66.35 13.00 7 36202 228328 90363910
Swelling 66.19 13.00 43 36166 419015 90173223
Hypersensitivity 66.11 13.00 51 36158 454626 90137612
Hepatic enzyme increased 65.67 13.00 31 36178 360705 90231533
Nasopharyngitis 65.36 13.00 41 36168 407063 90185175
Accidental death 64.75 13.00 26 36183 2022 90590216
Irritable bowel syndrome 63.93 13.00 5 36204 207443 90384795
Visceral congestion 62.93 13.00 17 36192 373 90591865
Delirium 61.93 13.00 132 36077 104227 90488011
Ventricular tachycardia 61.83 13.00 62 36147 24646 90567592
Sinusitis 60.15 13.00 31 36178 343057 90249181
General physical health deterioration 59.47 13.00 34 36175 355081 90237157
Respiratory acidosis 58.77 13.00 38 36171 8081 90584157
Seizure 58.39 13.00 163 36046 152466 90439772
Drug screen positive 58.38 13.00 29 36180 3728 90588510
Chorea 57.22 13.00 24 36185 2086 90590152
Pneumonia aspiration 57.15 13.00 76 36133 40864 90551374
Stress cardiomyopathy 56.31 13.00 45 36164 13310 90578928
Prescription drug used without a prescription 56.20 13.00 27 36182 3228 90589010
Infection 56.03 13.00 38 36171 362056 90230182
Suicidal ideation 55.34 13.00 103 36106 73752 90518486
Hypoxic-ischaemic encephalopathy 55.21 13.00 30 36179 4638 90587600
Contusion 55.09 13.00 16 36193 251200 90341038
Therapeutic product effect decreased 55.06 13.00 21 36188 277550 90314688
Intentional overdose 54.88 13.00 118 36091 93716 90498522
Type 2 diabetes mellitus 54.74 13.00 8 36201 203236 90389002
Poisoning deliberate 53.95 13.00 48 36161 16438 90575800
Myoclonus 53.38 13.00 51 36158 19117 90573121
Gastrointestinal disorder 53.33 13.00 18 36191 256669 90335569
Lower respiratory tract infection 53.09 13.00 17 36192 250642 90341596
Ill-defined disorder 52.87 13.00 6 36203 184885 90407353
Liver injury 52.86 13.00 4 36205 170563 90421675
Constipation 52.08 13.00 236 35973 280159 90312079
Impaired healing 51.20 13.00 15 36194 234184 90358054
Hypoglycaemia 50.58 13.00 96 36113 69752 90522486
Affective disorder 50.41 13.00 34 36175 7759 90584479
Brain oedema 49.83 13.00 47 36162 17338 90574900
Cyanosis 49.01 13.00 49 36160 19406 90572832
Blood cholesterol increased 47.96 13.00 12 36197 208000 90384238
Long QT syndrome 47.90 13.00 26 36183 4011 90588227
Pruritus 47.64 13.00 90 36119 541435 90050803
Pulmonary oedema 47.04 13.00 87 36122 61993 90530245
Osteoarthritis 45.69 13.00 11 36198 195719 90396519
Stomatitis 44.98 13.00 27 36182 274671 90317567
Lethargy 43.53 13.00 85 36124 63054 90529184
Respiratory failure 41.91 13.00 123 36086 118295 90473943
Blister 41.84 13.00 25 36184 254973 90337265
Restlessness 39.04 13.00 59 36150 35661 90556577
Bursitis 38.33 13.00 4 36205 131650 90460588
Caesarean section 38.23 13.00 42 36167 18535 90573703
Contraindicated product administered 38.13 13.00 43 36166 320096 90272142
Loss of consciousness 38.09 13.00 133 36076 140105 90452133
Peripheral swelling 36.88 13.00 68 36141 413038 90179200
Suspected counterfeit product 36.75 13.00 12 36197 514 90591724
Exposure via breast milk 36.36 13.00 18 36191 2297 90589941
Narcotic bowel syndrome 36.35 13.00 9 36200 138 90592100
Arthralgia 36.23 13.00 174 36035 778348 89813890
Diarrhoea 35.99 13.00 224 35985 938966 89653272
Aspiration 34.96 13.00 37 36172 15656 90576582
Aggression 34.92 13.00 48 36161 26620 90565618
Suicide attempt 34.38 13.00 86 36123 75313 90516925
Congenital nystagmus 33.90 13.00 7 36202 44 90592194
Lung disorder 33.86 13.00 9 36200 149874 90442364
Substance abuser 33.73 13.00 9 36200 188 90592050
Foetal growth restriction 32.07 13.00 28 36181 9352 90582886
Pyrexia 31.66 13.00 146 36063 660339 89931899
Fibromyalgia 31.41 13.00 22 36187 206247 90385991
Inadequate analgesia 30.76 13.00 18 36191 3206 90589032
Mobility decreased 30.60 13.00 33 36176 250701 90341537
Drug level increased 30.54 13.00 46 36163 27716 90564522
Crying 30.38 13.00 44 36165 25601 90566637
Low birth weight baby 29.86 13.00 27 36182 9440 90582798
Emotional distress 29.83 13.00 53 36156 36609 90555629
Cardio-respiratory distress 29.72 13.00 8 36201 173 90592065
Hypercholesterolaemia 29.54 13.00 3 36206 100889 90491349
Electrocardiogram QRS complex prolonged 29.37 13.00 24 36185 7324 90584914
Wound infection 29.08 13.00 4 36205 106398 90485840
Musculoskeletal stiffness 29.03 13.00 46 36163 296486 90295752
Treatment failure 28.95 13.00 48 36161 303880 90288358
Weaning failure 28.69 13.00 10 36199 524 90591714
Facet joint syndrome 28.61 13.00 3 36206 98386 90493852
Atrial fibrillation 28.39 13.00 9 36200 133602 90458636
Asthma 28.31 13.00 33 36176 242127 90350111
Premature baby 28.23 13.00 42 36167 25035 90567203
C-reactive protein abnormal 28.13 13.00 8 36201 127421 90464817
Brain hypoxia 28.07 13.00 10 36199 559 90591679
Hepatitis C 28.07 13.00 21 36188 5639 90586599
Neurological examination abnormal 27.85 13.00 9 36200 373 90591865
Ventricular fibrillation 27.61 13.00 31 36178 14013 90578225
Sciatica 27.26 13.00 4 36205 101378 90490860
Immune thrombocytopenia 27.20 13.00 30 36179 13296 90578942
Pulmonary congestion 27.00 13.00 36 36173 19397 90572841
Cerebral vasoconstriction 26.80 13.00 12 36197 1222 90591016
Hyperinsulinaemic hypoglycaemia 26.72 13.00 7 36202 136 90592102
Grip strength decreased 26.47 13.00 3 36206 92573 90499665
Thyroxine decreased 26.26 13.00 10 36199 675 90591563
Cough 26.12 13.00 69 36140 368893 90223345
Mydriasis 25.93 13.00 31 36178 14981 90577257
Joint range of motion decreased 25.68 13.00 11 36198 135632 90456606
Mental disorder 25.37 13.00 46 36163 32272 90559966
Pulmonary fibrosis 25.16 13.00 6 36203 107497 90484741
Musculoskeletal pain 25.11 13.00 19 36190 171232 90421006
Ileus 25.09 13.00 32 36177 16514 90575724
Chemical submission 24.96 13.00 9 36200 521 90591717
Erythema 24.95 13.00 33 36176 229213 90363025
Phyllodes tumour 24.87 13.00 6 36203 82 90592156
Substance dependence 24.82 13.00 7 36202 181 90592057
Small intestinal obstruction 24.53 13.00 36 36173 21198 90571040
Post-anoxic myoclonus 24.27 13.00 5 36204 31 90592207
Cardiopulmonary failure 24.09 13.00 17 36192 4171 90588067
Dizziness 23.85 13.00 138 36071 589146 90003092
Posterior reversible encephalopathy syndrome 23.14 13.00 36 36173 22303 90569935
Sleep disorder 23.13 13.00 27 36182 198003 90394235
Intestinal perforation 22.89 13.00 28 36181 13853 90578385
Neurotoxicity 22.81 13.00 35 36174 21432 90570806
Brachial artery entrapment syndrome 22.63 13.00 5 36204 45 90592193
Abdominal pain upper 22.21 13.00 64 36145 332610 90259628
Accidental exposure to product 22.19 13.00 51 36158 42315 90549923
Hypoaesthesia 22.05 13.00 59 36150 314151 90278087
Basal ganglia infarction 21.66 13.00 8 36201 496 90591742
Peripheral venous disease 21.04 13.00 4 36205 83917 90508321
Hallucination 20.97 13.00 66 36143 65893 90526345
C-reactive protein increased 20.89 13.00 25 36184 181364 90410874
Obesity 20.88 13.00 8 36201 105499 90486739
COVID-19 20.84 13.00 22 36187 168821 90423417
Autoimmune disorder 20.70 13.00 3 36206 76741 90515497
Imprisonment 20.69 13.00 7 36202 335 90591903
Tachyphylaxis 20.47 13.00 7 36202 346 90591892
Arthritis 20.43 13.00 22 36187 167293 90424945
Drug dependence, antepartum 20.36 13.00 5 36204 74 90592164
Bezoar 20.29 13.00 13 36196 2721 90589517
Altered state of consciousness 19.99 13.00 41 36168 31491 90560747
Hypoxia 19.94 13.00 69 36140 72330 90519908
Piloerection 19.73 13.00 8 36201 638 90591600
Secondary adrenocortical insufficiency 19.67 13.00 12 36197 2306 90589932
Night sweats 19.25 13.00 14 36195 128752 90463486
Allodynia 19.23 13.00 9 36200 1015 90591223
Moaning 19.07 13.00 9 36200 1034 90591204
Fatigue 18.97 13.00 336 35873 1153687 89438551
Colitis ischaemic 18.91 13.00 24 36185 12322 90579916
Knee arthroplasty 18.77 13.00 5 36204 83177 90509061
Housebound 18.77 13.00 6 36203 240 90591998
Post-traumatic stress disorder 18.69 13.00 18 36191 6810 90585428
Hepatitis 18.54 13.00 3 36206 70736 90521502
Toxic encephalopathy 18.48 13.00 20 36189 8679 90583559
Multiple drug therapy 18.30 13.00 18 36191 6991 90585247
Hallucination, visual 18.29 13.00 33 36176 23059 90569179
Maternal exposure during breast feeding 18.18 13.00 17 36192 6203 90586035
Electrocardiogram ST segment depression 18.06 13.00 13 36196 3290 90588948
Injury 18.02 13.00 32 36177 197317 90394921
Prescribed underdose 17.93 13.00 4 36205 75015 90517223
Mania 17.86 13.00 25 36184 14099 90578139
Lower limb fracture 17.58 13.00 6 36203 85007 90507231
Ventricular extrasystoles 17.58 13.00 24 36185 13226 90579012
Product use issue 17.56 13.00 70 36139 329849 90262389
Electrocardiogram PR shortened 17.56 13.00 7 36202 534 90591704
Factitious disorder 17.52 13.00 5 36204 135 90592103
Dyspepsia 17.32 13.00 33 36176 198127 90394111
Respiratory distress 17.31 13.00 44 36165 38902 90553336
Wheezing 17.24 13.00 44 36165 238036 90354202
Hyperreflexia 17.20 13.00 17 36192 6640 90585598
Chest discomfort 17.10 13.00 18 36191 138347 90453891
Leukocytosis 17.00 13.00 38 36171 30952 90561286
Sudden infant death syndrome 16.97 13.00 6 36203 328 90591910
Hyponatraemia 16.93 13.00 17 36192 133521 90458717
Glioblastoma multiforme 16.86 13.00 8 36201 930 90591308
Myocardial fibrosis 16.86 13.00 8 36201 931 90591307
Drug screen negative 16.83 13.00 6 36203 336 90591902
Retroperitoneal fibrosis 16.80 13.00 6 36203 338 90591900
Injection site reaction 16.59 13.00 8 36201 92072 90500166
Paranoia 16.55 13.00 23 36186 12885 90579353
Headache 16.54 13.00 244 35965 862502 89729736
Hypertension 16.50 13.00 111 36098 457421 90134817
Hip arthroplasty 16.42 13.00 5 36204 76203 90516035
Sudden death 16.38 13.00 21 36188 10888 90581350
Adulterated product 16.00 13.00 6 36203 388 90591850
Alcohol abuse 15.92 13.00 10 36199 2023 90590215
Gastroduodenal ulcer 15.74 13.00 6 36203 406 90591832
Pseudohyperkalaemia 15.65 13.00 3 36206 12 90592226
Genital herpes simplex 15.34 13.00 6 36203 435 90591803
Syphilis 15.05 13.00 5 36204 226 90592012
Maternal drugs affecting foetus 14.89 13.00 14 36195 5141 90587097
Radiation associated pain 14.79 13.00 5 36204 239 90591999
Postural tremor 14.78 13.00 6 36203 480 90591758
Parvovirus infection 14.63 13.00 6 36203 493 90591745
Dysphoria 14.59 13.00 15 36194 6139 90586099
Palpitations 14.55 13.00 20 36189 136708 90455530
Inflammation 14.53 13.00 31 36178 178561 90413677
Maternal use of illicit drugs 14.51 13.00 3 36206 19 90592219
Angioedema 14.45 13.00 4 36205 64872 90527366
Acute respiratory distress syndrome 14.44 13.00 34 36175 28652 90563586
Tachycardia 14.34 13.00 110 36099 157563 90434675
Gastrooesophageal reflux disease 14.28 13.00 28 36181 166309 90425929
Hypercapnic coma 14.24 13.00 5 36204 268 90591970
Sickle cell anaemia with crisis 14.16 13.00 16 36193 7281 90584957
Abnormal behaviour 13.85 13.00 29 36180 22599 90569639
Asthenia 13.58 13.00 142 36067 533609 90058629
Epilepsy 13.55 13.00 8 36201 82198 90510040
Wrong product administered 13.52 13.00 16 36193 7649 90584589
Incoherent 13.40 13.00 13 36196 4964 90587274
Mental impairment 13.38 13.00 24 36185 16696 90575542
Chest pain 13.37 13.00 74 36135 319571 90272667
Pain 13.35 13.00 300 35909 996041 89596197
Taste disorder 13.33 13.00 4 36205 61542 90530696
Echolalia 13.27 13.00 5 36204 328 90591910
Dependence 13.21 13.00 9 36200 2086 90590152
Neurosyphilis 13.21 13.00 3 36206 31 90592207
Drug ineffective for unapproved indication 13.03 13.00 57 36152 66587 90525651
Disinhibition 13.01 13.00 7 36202 1061 90591177

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Drug abuse 5831.15 14.67 2664 45251 102107 42471313
Toxicity to various agents 4146.51 14.67 2775 45140 226361 42347059
Respiratory depression 1170.66 14.67 521 47394 18347 42555073
Drug dependence 873.95 14.67 491 47424 28603 42544817
Overdose 766.74 14.67 755 47160 104509 42468911
Intentional product misuse 758.65 14.67 597 47318 61303 42512117
Coma 724.96 14.67 548 47367 53006 42520414
Poisoning 639.86 14.67 318 47597 14381 42559039
Miosis 636.43 14.67 308 47607 13138 42560282
Respiratory arrest 599.02 14.67 382 47533 28042 42545378
Electrocardiogram QT prolonged 551.99 14.67 446 47469 47499 42525921
Death 507.36 14.67 1409 46506 469776 42103644
Cardio-respiratory arrest 503.19 14.67 461 47454 58175 42515245
Bradypnoea 486.96 14.67 184 47731 4209 42569211
Asphyxia 431.33 14.67 203 47712 8123 42565297
Drug withdrawal syndrome 417.96 14.67 275 47640 21274 42552146
Torsade de pointes 374.10 14.67 186 47729 8408 42565012
Drug withdrawal syndrome neonatal 358.17 14.67 148 47767 4313 42569107
Completed suicide 354.43 14.67 487 47428 95978 42477442
Cardiac arrest 345.97 14.67 514 47401 108806 42464614
Substance abuse 341.73 14.67 177 47738 8728 42564692
Drug interaction 315.27 14.67 828 47087 266171 42307249
Withdrawal syndrome 312.13 14.67 199 47716 14576 42558844
Depressed level of consciousness 306.27 14.67 321 47594 47649 42525771
Drug use disorder 279.39 14.67 163 47752 10170 42563250
Pulmonary oedema 271.84 14.67 317 47598 52955 42520465
Brain oedema 265.72 14.67 187 47728 16140 42557280
Somnolence 235.03 14.67 501 47414 140604 42432816
Unresponsive to stimuli 218.18 14.67 220 47695 31183 42542237
Serotonin syndrome 196.11 14.67 190 47725 25655 42547765
Prescription drug used without a prescription 193.83 14.67 83 47832 2647 42570773
Accidental overdose 177.89 14.67 188 47727 28142 42545278
Drug diversion 168.67 14.67 57 47858 930 42572490
Brain injury 163.86 14.67 104 47811 7551 42565869
Diarrhoea 158.81 14.67 171 47744 460678 42112742
Substance use disorder 156.97 14.67 89 47826 5256 42568164
Drug screen positive 146.75 14.67 78 47837 4053 42569367
Visceral congestion 143.87 14.67 50 47865 891 42572529
Substance use 133.49 14.67 56 47859 1695 42571725
Respiratory acidosis 123.16 14.67 81 47834 6250 42567170
Myocardial fibrosis 118.49 14.67 47 47868 1228 42572192
Pyrexia 113.87 14.67 167 47748 393875 42179545
Foetal exposure during pregnancy 106.57 14.67 191 47724 47120 42526300
Neutropenia 102.54 14.67 48 47867 199383 42374037
Exposure via ingestion 101.51 14.67 49 47866 2073 42571347
Off label use 101.14 14.67 374 47541 637961 41935459
Hepatic fibrosis 98.84 14.67 64 47851 4808 42568612
Victim of child abuse 97.30 14.67 40 47875 1149 42572271
Poisoning deliberate 95.27 14.67 84 47831 10050 42563370
Epidural lipomatosis 93.53 14.67 44 47871 1756 42571664
Agitation 92.91 14.67 216 47699 64098 42509322
Pneumonia aspiration 92.76 14.67 186 47729 49892 42523528
Accidental poisoning 90.67 14.67 39 47876 1257 42572163
Febrile neutropenia 90.48 14.67 48 47867 185655 42387765
Delirium 88.96 14.67 188 47727 52331 42521089
Child abuse 86.82 14.67 34 47881 858 42572562
Condition aggravated 85.98 14.67 100 47815 260654 42312766
Cough 82.49 14.67 49 47866 178054 42395366
Housebound 79.62 14.67 23 47892 216 42573204
Hyperaesthesia 78.33 14.67 60 47855 5892 42567528
Juvenile idiopathic arthritis 77.64 14.67 44 47871 2595 42570825
Pulmonary congestion 77.46 14.67 92 47823 15638 42557782
Intentional overdose 76.71 14.67 175 47740 51281 42522139
Cardiopulmonary failure 74.68 14.67 53 47862 4630 42568790
Dyspnoea 74.10 14.67 253 47662 442368 42131052
Drug level increased 73.92 14.67 117 47798 26083 42547337
Rhabdomyolysis 72.06 14.67 222 47693 77797 42495623
Myoclonus 69.90 14.67 91 47824 16974 42556446
Hepatitis C 68.52 14.67 70 47845 10063 42563357
Laryngomalacia 67.68 14.67 22 47893 316 42573104
Substance abuser 67.60 14.67 21 47894 258 42573162
Substance-induced psychotic disorder 66.22 14.67 41 47874 2848 42570572
Rash 65.56 14.67 133 47782 276821 42296599
Accidental exposure to product by child 65.47 14.67 33 47882 1534 42571886
Infantile back arching 64.43 14.67 16 47899 78 42573342
Compartment syndrome 63.77 14.67 42 47873 3247 42570173
Sopor 63.01 14.67 76 47839 13126 42560294
General physical health deterioration 62.76 14.67 47 47868 151199 42422221
Hypercapnia 61.84 14.67 50 47865 5311 42568109
Postmortem blood drug level abnormal 61.01 14.67 21 47894 363 42573057
Asthenia 59.75 14.67 143 47772 280650 42292770
Altered state of consciousness 59.42 14.67 113 47802 29146 42544274
Sepsis 58.86 14.67 83 47832 199251 42374169
Leukoencephalopathy 58.83 14.67 47 47868 4907 42568513
Interstitial lung disease 58.73 14.67 9 47906 78453 42494967
Congenital nystagmus 58.52 14.67 15 47900 85 42573335
Sedation 57.38 14.67 114 47801 30361 42543059
Atrial fibrillation 57.11 14.67 44 47871 139549 42433871
Hypoxic-ischaemic encephalopathy 56.82 14.67 47 47868 5155 42568265
Withdrawal arrhythmia 54.43 14.67 13 47902 52 42573368
Platelet count decreased 52.59 14.67 47 47868 138534 42434886
Brachial plexopathy 52.58 14.67 13 47902 62 42573358
Arthralgia 52.52 14.67 94 47821 205144 42368276
Ventricular tachyarrhythmia 51.90 14.67 19 47896 396 42573024
Hypertonia neonatal 51.55 14.67 21 47894 589 42572831
Pruritus 50.54 14.67 84 47831 188687 42384733
Drug tolerance 49.63 14.67 36 47879 3254 42570166
Hyponatraemia 48.24 14.67 27 47888 101435 42471985
Fatigue 48.21 14.67 290 47625 435351 42138069
COVID-19 46.85 14.67 37 47878 115911 42457509
Substance dependence 46.57 14.67 20 47895 642 42572778
Anaemia 46.24 14.67 161 47754 280117 42293303
Loss of consciousness 45.46 14.67 215 47700 92139 42481281
Toxicologic test abnormal 44.96 14.67 18 47897 482 42572938
Acute kidney injury 44.68 14.67 237 47678 367100 42206320
Hyperinsulinaemic hypoglycaemia 44.27 14.67 13 47902 130 42573290
Stress cardiomyopathy 43.21 14.67 31 47884 2754 42570666
Pleural effusion 43.19 14.67 28 47887 97138 42476282
Tongue thrust 42.92 14.67 10 47905 35 42573385
Congenital hydrocephalus 41.39 14.67 13 47902 166 42573254
Disease progression 41.21 14.67 61 47854 143595 42429825
Regurgitation 40.62 14.67 26 47889 1914 42571506
Cardiac failure congestive 40.37 14.67 23 47892 85579 42487841
Product prescribing error 40.22 14.67 90 47825 26022 42547398
Decreased appetite 39.74 14.67 100 47815 193037 42380383
Aggression 39.21 14.67 124 47791 44039 42529381
Brain death 38.65 14.67 30 47885 3004 42570416
Breath holding 38.49 14.67 11 47904 99 42573321
Encephalopathy 38.49 14.67 118 47797 41215 42532205
Product dose omission issue 38.31 14.67 72 47843 154293 42419127
Pneumonia 37.77 14.67 299 47616 421850 42151570
Drug-induced liver injury 37.27 14.67 111 47804 38162 42535258
Thrombocytopenia 36.50 14.67 102 47813 190177 42383243
Suicide attempt 36.06 14.67 124 47791 45976 42527444
Cerebrovascular accident 35.61 14.67 34 47881 97126 42476294
Dizziness 34.80 14.67 153 47762 249101 42324319
Self-medication 34.61 14.67 29 47886 3237 42570183
Tonic posturing 34.56 14.67 8 47907 27 42573393
Dependence 33.91 14.67 21 47894 1459 42571961
Sudden cardiac death 33.86 14.67 31 47884 3893 42569527
Postmortem blood drug level 33.71 14.67 11 47904 160 42573260
Prostate cancer 33.68 14.67 5 47910 44638 42528782
White blood cell count decreased 33.52 14.67 45 47870 110351 42463069
Renal failure 33.11 14.67 70 47845 143656 42429764
Drug withdrawal maintenance therapy 33.04 14.67 11 47904 171 42573249
Foetal growth restriction 33.03 14.67 35 47880 5248 42568172
Cardiac failure 33.01 14.67 43 47872 106813 42466607
Joint swelling 32.47 14.67 18 47897 68004 42505416
Confusional state 32.43 14.67 309 47606 167288 42406132
Erythema 32.37 14.67 45 47870 108748 42464672
Poor sucking reflex 31.93 14.67 13 47902 364 42573056
Executive dysfunction 31.68 14.67 12 47903 276 42573144
Drug detoxification 31.41 14.67 13 47902 380 42573040
Aspiration 31.39 14.67 65 47850 17821 42555599
Haematuria 31.09 14.67 13 47902 57786 42515634
Dehydration 31.05 14.67 71 47844 141696 42431724
Sudden death 31.05 14.67 62 47853 16567 42556853
Drug ineffective 30.59 14.67 512 47403 629685 41943735
Asthma 30.46 14.67 16 47899 62298 42511122
Cyanosis 30.44 14.67 58 47857 14973 42558447
Toxic encephalopathy 29.92 14.67 38 47877 6915 42566505
Urticaria 29.42 14.67 24 47891 74012 42499408
Muscle mass 29.24 14.67 11 47904 248 42573172
Ectopic kidney 29.11 14.67 7 47908 29 42573391
Myocardial infarction 28.89 14.67 60 47855 123949 42449471
Hypercapnic coma 28.89 14.67 10 47905 176 42573244
Productive cough 28.71 14.67 11 47904 51556 42521864
Neutrophil count decreased 28.55 14.67 18 47897 63397 42510023
Haemoglobin decreased 28.48 14.67 67 47848 132404 42441016
Blood creatinine increased 28.44 14.67 50 47865 109953 42463467
Oedema peripheral 28.32 14.67 70 47845 136006 42437414
Aspartate aminotransferase increased 28.27 14.67 27 47888 77136 42496284
Brachial plexus injury 27.70 14.67 8 47907 75 42573345
Dyspnoea exertional 27.42 14.67 11 47904 50137 42523283
Transient ischaemic attack 27.33 14.67 3 47912 33736 42539684
Incorrect route of product administration 27.07 14.67 74 47841 24231 42549189
Congestive hepatopathy 27.01 14.67 22 47893 2360 42571060
Hypersensitivity 26.89 14.67 25 47890 72345 42501075
Renal impairment 26.82 14.67 52 47863 110176 42463244
Brain herniation 26.75 14.67 30 47885 4793 42568627
Bladder dilatation 26.65 14.67 19 47896 1671 42571749
IVth nerve disorder 26.45 14.67 6 47909 18 42573402
Electrocardiogram QT shortened 26.12 14.67 9 47906 156 42573264
Diabetes mellitus 25.77 14.67 18 47897 60069 42513351
Myocardial oedema 25.62 14.67 10 47905 250 42573170
Rheumatoid arthritis 25.44 14.67 8 47907 42432 42530988
Apnoea 25.04 14.67 37 47878 7766 42565654
Respiratory rate decreased 24.90 14.67 23 47892 2922 42570498
Neuropathy peripheral 24.82 14.67 48 47867 101805 42471615
Tachycardia 24.55 14.67 196 47719 100891 42472529
Haematochezia 24.41 14.67 18 47897 58418 42515002
Leukopenia 24.21 14.67 29 47886 74717 42498703
Abdominal pain 24.15 14.67 121 47794 190350 42383070
Cataract 24.10 14.67 3 47912 30601 42542819
International normalised ratio increased 24.09 14.67 12 47903 48156 42525264
Hospitalisation 23.90 14.67 29 47886 74301 42499119
Alcohol abuse 23.86 14.67 26 47889 4023 42569397
Therapeutic product effect incomplete 23.54 14.67 27 47888 70912 42502508
Postoperative ileus 23.52 14.67 13 47902 730 42572690
Peripheral swelling 23.36 14.67 41 47874 90229 42483191
Sinusitis 23.32 14.67 12 47903 47280 42526140
Mydriasis 23.14 14.67 38 47877 8732 42564688
Nasopharyngitis 22.80 14.67 37 47878 83959 42489461
Wheezing 22.72 14.67 17 47898 54764 42518656
Biliary dilatation 22.67 14.67 16 47899 1385 42572035
Testicular atrophy 22.63 14.67 12 47903 620 42572800
Ventricular tachycardia 22.60 14.67 80 47835 30080 42543340
Imprisonment 22.42 14.67 12 47903 632 42572788
Blood glucose increased 22.41 14.67 30 47885 73669 42499751
Infection 22.27 14.67 59 47856 112009 42461411
Mental status changes 22.14 14.67 100 47815 42015 42531405
Chronic obstructive pulmonary disease 22.07 14.67 23 47892 63091 42510329
Gout 21.49 14.67 3 47912 28052 42545368
Drug intolerance 21.29 14.67 36 47879 80388 42493032
Haemoptysis 20.92 14.67 13 47902 46154 42527266
Incoherent 20.78 14.67 26 47889 4659 42568761
Intentional misuse of drug delivery system 20.74 14.67 5 47910 21 42573399
Weight increased 20.60 14.67 58 47857 107925 42465495
Chronic kidney disease 20.46 14.67 14 47901 47227 42526193
Melaena 20.38 14.67 9 47906 38737 42534683
Device toxicity 20.37 14.67 5 47910 23 42573397
Visceral oedema 20.17 14.67 6 47909 63 42573357
Lactic acidosis 20.16 14.67 13 47902 45248 42528172
Abdominal distension 20.03 14.67 31 47884 71704 42501716
Chills 19.87 14.67 48 47867 94018 42479402
Euphoric mood 19.85 14.67 30 47885 6423 42566997
Brain hypoxia 19.77 14.67 11 47904 626 42572794
Withdrawal hypertension 19.55 14.67 8 47907 227 42573193
Blood lactate dehydrogenase increased 19.49 14.67 3 47912 26078 42547342
Hypertonia 19.44 14.67 26 47889 4975 42568445
Coronary artery disease 19.44 14.67 19 47896 53701 42519719
Eczema 19.43 14.67 7 47908 34079 42539341
Rash maculo-papular 19.27 14.67 9 47906 37494 42535926
Musculoskeletal stiffness 19.15 14.67 22 47893 57743 42515677
Lymphocyte count decreased 19.05 14.67 4 47911 27805 42545615
Tongue biting 18.96 14.67 13 47902 1074 42572346
Disease recurrence 18.88 14.67 5 47910 29673 42543747
Neurotoxicity 18.82 14.67 64 47851 23587 42549833
Arachnoiditis 18.55 14.67 9 47906 385 42573035
Psoriatic arthropathy 18.37 14.67 3 47912 24964 42548456
Cytokine release syndrome 18.23 14.67 14 47901 44513 42528907
Obesity 18.22 14.67 50 47865 16409 42557011
Pulmonary embolism 18.17 14.67 71 47844 119541 42453879
Obstructive airways disorder 18.16 14.67 3 47912 24756 42548664
Deep vein thrombosis 18.11 14.67 37 47878 76920 42496500
Thrombosis 17.83 14.67 31 47884 68480 42504940
Pain in extremity 17.78 14.67 98 47817 150506 42422914
Pneumoconiosis 17.62 14.67 8 47907 294 42573126
Upper respiratory tract infection 17.60 14.67 13 47902 42160 42531260
Hypothyroidism 17.60 14.67 7 47908 32077 42541343
Hyperreflexia 17.59 14.67 21 47894 3586 42569834
Drug level above therapeutic 17.52 14.67 27 47888 5879 42567541
Pyramidal tract syndrome 17.52 14.67 8 47907 298 42573122
Colitis 17.40 14.67 16 47899 46556 42526864
Drug tolerance increased 17.38 14.67 9 47906 443 42572977
Foetal heart rate indeterminate 17.38 14.67 3 47912 0 42573420
Restlessness 17.33 14.67 72 47843 29177 42544243
Full blood count abnormal 17.26 14.67 6 47909 29870 42543550
Alanine aminotransferase increased 17.22 14.67 47 47868 88359 42485061
Urinary tract infection 17.02 14.67 56 47859 99228 42474192
Kidney congestion 16.99 14.67 9 47906 464 42572956
Maternal exposure during breast feeding 16.88 14.67 14 47901 1541 42571879
Accidental death 16.80 14.67 19 47896 3064 42570356
Congenital hypothyroidism 16.75 14.67 4 47911 16 42573404
Eosinophilia 16.75 14.67 8 47907 32891 42540529
Epistaxis 16.71 14.67 31 47884 66795 42506625
Renal vein thrombosis 16.66 14.67 9 47906 483 42572937
Angioedema 16.59 14.67 14 47901 42463 42530957
Left ventricular hypertrophy 16.51 14.67 34 47881 9285 42564135
Drug eruption 16.48 14.67 3 47912 23072 42550348
Drug resistance 16.43 14.67 9 47906 34239 42539181
Product communication issue 16.42 14.67 12 47903 1097 42572323
C-reactive protein increased 16.32 14.67 29 47886 63531 42509889
Ventricular arrhythmia 16.29 14.67 27 47888 6252 42567168
Dysarthria 16.28 14.67 88 47827 39719 42533701
Herpes zoster 16.21 14.67 12 47903 38865 42534555
Diverticulitis 16.18 14.67 3 47912 22770 42550650
Myelodysplastic syndrome 16.15 14.67 3 47912 22742 42550678
Basal cell carcinoma 16.14 14.67 3 47912 22730 42550690
Injection site pain 16.12 14.67 25 47890 57773 42515647
Toxic epidermal necrolysis 16.11 14.67 5 47910 26745 42546675
Nerve injury 16.07 14.67 21 47894 3929 42569491
Elbow synostosis 16.02 14.67 4 47911 20 42573400
Cardiac death 16.01 14.67 12 47903 1140 42572280
Upper gastrointestinal haemorrhage 15.99 14.67 7 47908 30292 42543128
Paraesthesia 15.90 14.67 37 47878 73422 42499998
Chronic hepatitis C 15.89 14.67 9 47906 530 42572890
Product administered to patient of inappropriate age 15.89 14.67 23 47892 4738 42568682
Viral infection 15.89 14.67 3 47912 22480 42550940
Pancreatitis acute 15.84 14.67 9 47906 33555 42539865
Product use in unapproved indication 15.80 14.67 132 47783 184324 42389096
Hyperglycaemia 15.71 14.67 17 47898 45842 42527578
Chloasma 15.71 14.67 4 47911 22 42573398
Acute myeloid leukaemia 15.66 14.67 3 47912 22253 42551167
Hepatic function abnormal 15.66 14.67 21 47894 51546 42521874
Accident 15.59 14.67 27 47888 6476 42566944
Psoriasis 15.58 14.67 19 47896 48585 42524835
Stress 15.58 14.67 16 47899 44196 42529224
Cardiac hypertrophy 15.57 14.67 12 47903 1189 42572231
Antemortem blood drug level abnormal 15.56 14.67 5 47910 69 42573351
Weight decreased 15.56 14.67 154 47761 207794 42365626
Cluster headache 15.54 14.67 9 47906 553 42572867
Suicidal ideation 15.52 14.67 100 47815 48061 42525359
Hypoaesthesia 15.46 14.67 36 47879 71427 42501993
Fall 15.41 14.67 179 47736 234341 42339079
Ascites 15.34 14.67 25 47890 56653 42516767
Sinus bradycardia 15.34 14.67 44 47871 14809 42558611
Premature baby 15.32 14.67 59 47856 23094 42550326
Extramedullary haemopoiesis 15.30 14.67 6 47909 152 42573268
Central nervous system necrosis 15.30 14.67 7 47908 262 42573158
Accidental exposure to product 15.20 14.67 54 47861 20339 42553081
Intentional device misuse 15.17 14.67 7 47908 267 42573153
Coma scale abnormal 15.16 14.67 22 47893 4543 42568877
Drug reaction with eosinophilia and systemic symptoms 15.09 14.67 15 47900 42060 42531360
Arthritis 15.08 14.67 15 47900 42050 42531370
Arterial injury 14.97 14.67 8 47907 420 42573000
Paranoia 14.92 14.67 42 47873 13984 42559436
Gastric bypass 14.86 14.67 7 47908 280 42573140
Orthostatic hypotension 14.71 14.67 8 47907 30562 42542858
Flushing 14.71 14.67 12 47903 37016 42536404

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Drug abuse 9768.09 12.64 3865 70987 173546 110340901
Toxicity to various agents 6691.69 12.64 4092 70760 476463 110037984
Respiratory depression 1817.13 12.64 717 74135 31284 110483163
Respiratory arrest 1474.91 12.64 741 74111 57558 110456889
Death 1419.37 12.64 2032 72820 696837 109817610
Completed suicide 1389.28 12.64 1215 73637 241166 110273281
Overdose 1301.75 12.64 1153 73699 232641 110281806
Cardio-respiratory arrest 1222.49 12.64 835 74017 115001 110399446
Drug dependence 1221.79 12.64 621 74231 49399 110465048
Intentional product misuse 1146.10 12.64 847 74005 132057 110382390
Cardiac arrest 1062.15 12.64 954 73898 195799 110318648
Poisoning 1029.26 12.64 466 74386 28639 110485808
Coma 937.70 12.64 716 74136 117153 110397294
Miosis 899.63 12.64 390 74462 21593 110492854
Drug withdrawal syndrome 824.30 12.64 436 74416 37618 110476829
Electrocardiogram QT prolonged 816.64 12.64 639 74213 108321 110406126
Torsade de pointes 687.26 12.64 326 74526 22274 110492173
Asphyxia 630.38 12.64 267 74585 13948 110500499
Bradypnoea 624.18 12.64 231 74621 8418 110506029
Depressed level of consciousness 563.16 12.64 523 74329 111755 110402692
Drug interaction 536.32 12.64 1098 73754 499085 110015362
Substance abuse 516.01 12.64 223 74629 12240 110502207
Drug use disorder 472.09 12.64 235 74617 17839 110496608
Withdrawal syndrome 430.52 12.64 267 74585 31113 110483334
Accidental overdose 423.01 12.64 320 74532 51514 110462933
Somnolence 409.65 12.64 727 74125 296722 110217725
Unresponsive to stimuli 391.01 12.64 333 74519 63457 110450990
Brain oedema 341.33 12.64 230 74622 30868 110483579
Pulmonary oedema 338.46 12.64 378 74474 100281 110414166
Substance use disorder 330.08 12.64 139 74713 7151 110507296
Substance use 289.18 12.64 95 74757 2411 110512036
Hyperaesthesia 261.38 12.64 148 74704 14579 110499868
Premature delivery 258.51 12.64 193 74659 30439 110484008
Suicide attempt 242.95 12.64 324 74528 103070 110411377
Visceral congestion 239.26 12.64 71 74781 1274 110513173
Accidental poisoning 226.77 12.64 79 74773 2408 110512039
Exposure via ingestion 213.75 12.64 91 74761 4809 110509638
Congenital nystagmus 210.12 12.64 40 74812 74 110514373
Intentional overdose 209.93 12.64 345 74507 132156 110382291
Serotonin syndrome 198.51 12.64 222 74630 58931 110455516
Respiratory acidosis 190.50 12.64 118 74734 13708 110500739
Pneumonia aspiration 185.37 12.64 251 74601 80982 110433465
Accidental exposure to product by child 182.52 12.64 72 74780 3126 110511321
Drug diversion 182.42 12.64 58 74794 1322 110513125
Agitation 181.28 12.64 296 74556 112755 110401692
Brain injury 180.59 12.64 113 74739 13363 110501084
Diarrhoea 178.32 12.64 312 74540 1139193 109375254
Drug screen positive 172.27 12.64 85 74767 6325 110508122
Prescription drug used without a prescription 166.16 12.64 79 74773 5417 110509030
Drug withdrawal syndrome neonatal 165.98 12.64 40 74812 305 110514142
Sedation 164.62 12.64 219 74633 69464 110444983
Poisoning deliberate 154.24 12.64 134 74718 26197 110488250
Systemic lupus erythematosus 146.19 12.64 6 74846 254332 110260115
Myocardial fibrosis 139.22 12.64 52 74800 1943 110512504
Leukoencephalopathy 138.27 12.64 83 74769 9112 110505335
Rash 138.25 12.64 214 74638 820750 109693697
Synovitis 138.16 12.64 13 74839 274079 110240368
Strabismus congenital 135.06 12.64 24 74828 23 110514424
Joint swelling 132.72 12.64 67 74785 442778 110071669
Glossodynia 128.39 12.64 5 74847 221999 110292448
General physical health deterioration 127.97 12.64 64 74788 425231 110089216
Infusion related reaction 126.23 12.64 50 74802 381112 110133335
Myoclonus 121.39 12.64 130 74722 32868 110481579
Drug level increased 120.50 12.64 155 74697 47564 110466883
Rheumatoid arthritis 119.56 12.64 28 74824 299585 110214862
Urticaria 119.20 12.64 34 74818 318823 110195624
Alopecia 118.91 12.64 49 74803 364704 110149743
Hypoxic-ischaemic encephalopathy 118.08 12.64 74 74778 8773 110505674
Abdominal discomfort 117.39 12.64 60 74792 393798 110120649
Victim of child abuse 116.34 12.64 40 74812 1171 110513276
Pulmonary congestion 115.69 12.64 123 74729 30843 110483604
Hypersensitivity 115.35 12.64 65 74787 403933 110110514
Pyrexia 114.76 12.64 276 74576 897989 109616458
Nasopharyngitis 114.69 12.64 62 74790 394299 110120148
Pericarditis 114.22 12.64 9 74843 219105 110295342
Delirium 114.09 12.64 270 74582 134755 110379692
Drug intolerance 113.79 12.64 67 74785 406445 110108002
Pruritus 113.54 12.64 136 74716 581424 109933023
Cardiopulmonary failure 112.82 12.64 69 74783 7834 110506613
Arthropathy 110.59 12.64 29 74823 287493 110226954
Sinusitis 110.23 12.64 32 74820 296656 110217791
Epidural lipomatosis 109.14 12.64 44 74808 2023 110512424
Duodenal ulcer perforation 106.29 12.64 3 74849 177697 110336750
Substance abuser 106.28 12.64 30 74822 447 110514000
Arthralgia 105.63 12.64 232 74620 779400 109735047
Helicobacter infection 105.49 12.64 4 74848 181873 110332574
Aggression 104.46 12.64 162 74690 59048 110455399
Child abuse 103.78 12.64 34 74818 855 110513592
Psoriatic arthropathy 102.78 12.64 8 74844 196753 110317694
Housebound 102.62 12.64 29 74823 434 110514013
Hepatic fibrosis 99.02 12.64 64 74788 8002 110506445
Irritable bowel syndrome 97.39 12.64 3 74849 164212 110350235
Swelling 96.62 12.64 59 74793 350982 110163465
Cough 92.16 12.64 106 74746 461535 110052912
Peripheral swelling 90.56 12.64 84 74768 403950 110110497
Rhabdomyolysis 90.28 12.64 230 74622 120171 110394276
Ventricular tachycardia 89.86 12.64 138 74714 49871 110464576
Drug abuser 89.66 12.64 52 74800 5357 110509090
Hepatic enzyme increased 88.22 12.64 54 74798 320838 110193609
Impaired healing 87.71 12.64 14 74838 196703 110317744
Fatigue 87.19 12.64 476 74376 1215482 109298965
Therapeutic product effect decreased 86.00 12.64 29 74823 244287 110270160
Ill-defined disorder 85.96 12.64 5 74847 156848 110357599
Mental status changes 85.76 12.64 171 74681 75951 110438496
Condition aggravated 85.14 12.64 237 74615 734599 109779848
Blood cholesterol increased 85.03 12.64 12 74840 184773 110329674
Stress cardiomyopathy 83.74 12.64 76 74776 15730 110498717
Altered state of consciousness 83.16 12.64 144 74708 57482 110456965
Infection 82.71 12.64 74 74778 362126 110152321
Stomatitis 82.24 12.64 40 74812 270202 110244245
Toxic leukoencephalopathy 80.51 12.64 33 74819 1584 110512863
Loss of consciousness 79.85 12.64 303 74549 196003 110318444
Hepatitis C 79.78 12.64 67 74785 12506 110501941
Muscle injury 78.68 12.64 4 74848 140803 110373644
Discomfort 78.20 12.64 24 74828 214683 110299764
Cyanosis 75.70 12.64 97 74755 29644 110484803
Osteoarthritis 74.97 12.64 16 74836 182607 110331840
Fibromyalgia 74.33 12.64 13 74839 170896 110343551
Off label use 74.12 12.64 655 74197 1499530 109014917
Substance-induced psychotic disorder 73.98 12.64 46 74806 5378 110509069
Wound 73.96 12.64 33 74819 234404 110280043
Aspiration 70.61 12.64 95 74757 30438 110484009
Gastrointestinal disorder 70.36 12.64 38 74814 241914 110272533
Asthma 70.35 12.64 41 74811 250250 110264197
Dizziness 70.32 12.64 240 74612 697953 109816494
Blister 70.18 12.64 33 74819 227343 110287104
Dyspnoea 69.89 12.64 451 74401 1106421 109408026
Substance dependence 69.85 12.64 24 74828 701 110513746
Hypercapnia 69.85 12.64 59 74793 11100 110503347
Accidental death 69.63 12.64 43 74809 4966 110509481
Neutropenia 69.49 12.64 91 74761 374529 110139918
Foetal exposure during pregnancy 69.43 12.64 50 74802 7455 110506992
Asthenia 69.28 12.64 237 74615 688762 109825685
Contraindicated product administered 67.91 12.64 42 74810 248225 110266222
Type 2 diabetes mellitus 67.89 12.64 18 74834 177214 110337233
Febrile neutropenia 65.07 12.64 71 74781 316696 110197751
Hypoaesthesia 65.03 12.64 70 74782 314153 110200294
Juvenile idiopathic arthritis 64.87 12.64 44 74808 5963 110508484
Postmortem blood drug level abnormal 64.84 12.64 22 74830 618 110513829
Musculoskeletal stiffness 62.88 12.64 58 74794 279764 110234683
Erythema 61.34 12.64 64 74788 291383 110223064
Withdrawal arrhythmia 61.00 12.64 13 74839 52 110514395
Wheezing 60.86 12.64 50 74802 255180 110259267
Bursitis 60.80 12.64 8 74844 129910 110384537
Contusion 60.41 12.64 42 74810 233319 110281128
Long QT syndrome 60.37 12.64 45 74807 7073 110507374
Sopor 60.32 12.64 97 74755 36449 110477998
Encephalopathy 59.88 12.64 154 74698 80901 110433546
COVID-19 59.69 12.64 47 74805 245013 110269434
Hyperinsulinaemic hypoglycaemia 58.93 12.64 17 74835 275 110514172
Compartment syndrome 58.43 12.64 41 74811 5869 110508578
C-reactive protein abnormal 58.33 12.64 9 74843 129686 110384761
Lower respiratory tract infection 57.50 12.64 48 74804 243058 110271389
Suicidal ideation 56.96 12.64 166 74686 93771 110420676
Musculoskeletal pain 55.81 12.64 27 74825 182996 110331451
Joint range of motion decreased 53.56 12.64 9 74843 121823 110392624
Facet joint syndrome 53.31 12.64 3 74849 96825 110417622
Alcohol abuse 52.98 12.64 36 74816 4893 110509554
Hyponatraemia 52.69 12.64 42 74810 217611 110296836
Lethargy 52.60 12.64 161 74691 93415 110421032
Sudden death 52.04 12.64 73 74779 24322 110490125
Myelosuppression 51.71 12.64 3 74849 94337 110420110
Respiratory failure 51.33 12.64 284 74568 215048 110299399
Lung disorder 51.29 12.64 29 74823 180018 110334429
Atrial fibrillation 51.11 12.64 48 74804 229594 110284853
Restlessness 50.23 12.64 115 74737 56144 110458303
Catatonia 49.67 12.64 49 74803 11251 110503196
Drug withdrawal maintenance therapy 49.03 12.64 13 74839 151 110514296
Treatment failure 48.71 12.64 70 74782 277164 110237283
Gastrooesophageal reflux disease 48.45 12.64 31 74821 179945 110334502
Paraesthesia 48.41 12.64 70 74782 276451 110237996
Mydriasis 48.30 12.64 67 74785 22090 110492357
C-reactive protein increased 46.81 12.64 47 74805 217872 110296575
Arthritis 46.31 12.64 28 74824 167558 110346889
Brain death 45.83 12.64 37 74815 6536 110507911
Pain 45.21 12.64 421 74431 954534 109559913
Wound infection 44.99 12.64 6 74846 96459 110417988
Sciatica 44.93 12.64 5 74847 92394 110422053
Mobility decreased 44.69 12.64 57 74795 237365 110277082
Pain in extremity 44.66 12.64 174 74678 486944 110027503
Congenital visual acuity reduced 43.91 12.64 8 74844 10 110514437
Pulmonary fibrosis 43.85 12.64 8 74844 102034 110412413
Brain hypoxia 43.62 12.64 20 74832 1262 110513185
Chorea 43.02 12.64 27 74825 3208 110511239
Headache 42.62 12.64 387 74465 881990 109632457
Grip strength decreased 42.60 12.64 3 74849 80171 110434276
Toxic encephalopathy 42.52 12.64 52 74800 15162 110499285
Decreased appetite 42.33 12.64 172 74680 475674 110038773
Incoherent 41.96 12.64 39 74813 8319 110506128
Hypercapnic coma 41.78 12.64 15 74837 500 110513947
Liver injury 41.74 12.64 25 74827 150388 110364059
Product prescribing error 41.55 12.64 101 74751 51230 110463217
Tachycardia 41.39 12.64 279 74573 226366 110288081
Regurgitation 41.18 12.64 27 74825 3458 110510989
Brachial plexopathy 41.02 12.64 13 74839 293 110514154
Abdominal pain upper 40.78 12.64 112 74740 348999 110165448
Paranoia 40.55 12.64 62 74790 22312 110492135
Anaemia 40.23 12.64 212 74640 546874 109967573
Toxicologic test abnormal 40.16 12.64 19 74833 1288 110513159
Inflammation 40.01 12.64 43 74809 193195 110321252
Peripheral venous disease 39.79 12.64 5 74847 84112 110430335
Neurotoxicity 38.48 12.64 87 74765 42120 110472327
Sudden cardiac death 37.76 12.64 31 74821 5606 110508841
Night sweats 37.56 12.64 22 74830 133961 110380486
Hypoglycaemia 37.53 12.64 167 74685 115937 110398510
Malaise 37.23 12.64 284 74568 671535 109842912
Testicular atrophy 37.10 12.64 13 74839 403 110514044
Executive dysfunction 36.83 12.64 13 74839 412 110514035
Drug hypersensitivity 36.80 12.64 170 74682 453920 110060527
Injection site reaction 36.15 12.64 8 74844 89062 110425385
Weight increased 35.27 12.64 155 74697 419489 110094958
Self-medication 35.06 12.64 31 74821 6201 110508246
Postoperative ileus 34.98 12.64 17 74835 1223 110513224
Hallucination 34.38 12.64 148 74704 101284 110413163
Hypertension 34.05 12.64 204 74648 509880 110004567
Interstitial lung disease 33.57 12.64 27 74825 139307 110375140
Autoimmune disorder 33.26 12.64 3 74849 65480 110448967
Respiratory rate decreased 32.97 12.64 30 74822 6228 110508219
Knee arthroplasty 32.92 12.64 3 74849 64945 110449502
Brain herniation 32.74 12.64 35 74817 8828 110505619
Drug detoxification 32.72 12.64 13 74839 575 110513872
Drug tolerance increased 32.53 12.64 13 74839 584 110513863
Postmortem blood drug level 32.42 12.64 11 74841 309 110514138
Pneumoconiosis 32.35 12.64 11 74841 311 110514136
Developmental delay 32.30 12.64 17 74835 1448 110512999
Maternal exposure during pregnancy 32.20 12.64 288 74564 254595 110259852
Injection site pain 32.16 12.64 44 74808 177878 110336569
Inadequate analgesia 32.10 12.64 27 74825 5050 110509397
Product dose omission issue 32.06 12.64 111 74741 321671 110192776
Dyspepsia 31.81 12.64 50 74802 190915 110323532
Seizure 31.67 12.64 257 74595 220928 110293519
Muscle mass 31.56 12.64 12 74840 471 110513976
Apnoea 30.87 12.64 42 74810 13597 110500850
Bezoar 30.80 12.64 24 74828 4030 110510417
Hyperreflexia 30.78 12.64 35 74817 9450 110504997
Chronic hepatitis C 30.51 12.64 13 74839 688 110513759
Cardiac hypertrophy 30.38 12.64 18 74834 1929 110512518
Sleep disorder 30.33 12.64 55 74797 198589 110315858
Platelet count decreased 29.94 12.64 70 74782 230373 110284074
Imprisonment 29.52 12.64 13 74839 746 110513701
IVth nerve disorder 29.49 12.64 6 74846 18 110514429
Congestive hepatopathy 29.43 12.64 26 74826 5194 110509253
Crying 29.37 12.64 58 74794 25570 110488877
Loss of personal independence in daily activities 29.29 12.64 35 74817 149985 110364462
Chest pain 29.26 12.64 143 74709 376232 110138215
Rash pruritic 29.09 12.64 15 74837 98054 110416393
Ventricular arrhythmia 29.04 12.64 35 74817 10052 110504395
Cardiac failure congestive 28.67 12.64 36 74816 150964 110363483
Chest discomfort 28.50 12.64 46 74806 173802 110340645
Coma scale abnormal 28.41 12.64 34 74818 9692 110504755
Prescribed underdose 28.24 12.64 5 74847 65169 110449278
Potentiating drug interaction 28.11 12.64 37 74815 11606 110502841
Muscular weakness 28.05 12.64 81 74771 248387 110266060
Liver disorder 27.97 12.64 33 74819 142210 110372237
Piloerection 27.83 12.64 13 74839 856 110513591
Herpes zoster 27.38 12.64 20 74832 108359 110406088
Brachial plexus injury 27.31 12.64 8 74844 137 110514310
Psoriasis 26.97 12.64 33 74819 139960 110374487
Respiratory distress 26.90 12.64 105 74747 68769 110445678
Emphysema 26.73 12.64 48 74804 19708 110494739
Lower limb fracture 26.40 12.64 9 74843 75339 110439108
Hepatitis 26.37 12.64 14 74838 90040 110424407
Pulmonary haemorrhage 26.23 12.64 43 74809 16413 110498034
Confusional state 26.10 12.64 454 74398 468226 110046221
Euphoric mood 26.02 12.64 31 74821 8796 110505651
Narcotic bowel syndrome 25.97 12.64 9 74843 270 110514177
Epilepsy 25.96 12.64 18 74834 100191 110414256
Nausea 25.91 12.64 638 74214 1235052 109279395
Colitis ulcerative 25.82 12.64 10 74842 77353 110437094
Constipation 25.79 12.64 362 74490 357424 110157023
Migraine 25.78 12.64 48 74804 171604 110342843
Exposure via breast milk 25.76 12.64 13 74839 1015 110513432
Suspected counterfeit product 25.64 12.64 12 74840 794 110513653
Central nervous system necrosis 25.28 12.64 10 74842 437 110514010
Electrocardiogram QT shortened 25.27 12.64 9 74843 293 110514154
Therapeutic product effect incomplete 25.23 12.64 73 74779 223732 110290715
Hepatotoxicity 25.12 12.64 6 74846 63394 110451053
Dry mouth 24.97 12.64 62 74790 199886 110314561
Oedema peripheral 24.89 12.64 126 74726 328534 110185913
Post-anoxic myoclonus 24.64 12.64 6 74846 48 110514399
Accidental exposure to product 24.42 12.64 82 74770 49926 110464521
Optic nerve hypoplasia 24.33 12.64 5 74847 16 110514431
Bladder dilatation 24.30 12.64 17 74835 2422 110512025
Allodynia 24.28 12.64 16 74836 2067 110512380
Upper respiratory tract infection 24.22 12.64 32 74820 131296 110383151
Productive cough 24.14 12.64 25 74827 114280 110400167
Intentional misuse of drug delivery system 24.10 12.64 5 74847 17 110514430
Oedema 24.03 12.64 68 74784 209908 110304539
Hypoxia 23.97 12.64 160 74692 129355 110385092
Hypercholesterolaemia 23.96 12.64 16 74836 90821 110423626
Sepsis 23.95 12.64 127 74725 327219 110187228
Neutrophil count decreased 23.84 12.64 28 74824 120913 110393534
Angioedema 23.83 12.64 19 74833 98481 110415966
Hyperhidrosis 23.83 12.64 212 74640 187086 110327361
Accident 23.70 12.64 33 74819 10919 110503528
Snoring 23.68 12.64 26 74826 6758 110507689
Kidney congestion 23.66 12.64 10 74842 519 110513928
Left ventricular hypertrophy 23.02 12.64 36 74816 13208 110501239
Device toxicity 22.90 12.64 5 74847 23 110514424
Leukopenia 22.89 12.64 41 74811 148750 110365697
Hip arthroplasty 22.67 12.64 5 74847 55808 110458639
Abnormal dreams 22.58 12.64 35 74817 12745 110501702
Visceral oedema 22.23 12.64 6 74846 75 110514372
Weaning failure 22.21 12.64 11 74841 825 110513622
Cardiac death 22.16 12.64 14 74838 1682 110512765
Injury 22.11 12.64 55 74797 177210 110337237
Myocardial oedema 22.08 12.64 10 74842 613 110513834
Bone marrow disorder 21.77 12.64 20 74832 4203 110510244
Cardio-respiratory distress 21.59 12.64 8 74844 292 110514155
Affective disorder 21.58 12.64 32 74820 11209 110503238
Eczema 21.52 12.64 11 74841 72282 110442165
Haematochezia 21.45 12.64 28 74824 115496 110398951
Drug eruption 21.41 12.64 5 74847 53654 110460793
Cardiac failure 21.29 12.64 61 74791 187565 110326882
Aspartate aminotransferase increased 21.24 12.64 48 74804 159888 110354559
Phyllodes tumour 21.22 12.64 6 74846 90 110514357
Diabetic hyperglycaemic coma 21.16 12.64 6 74846 91 110514356
Cerebral vasoconstriction 21.16 12.64 13 74839 1488 110512959
Exostosis 21.09 12.64 3 74849 45953 110468494
Rash maculo-papular 21.07 12.64 12 74840 74210 110440237
Frequent bowel movements 21.05 12.64 11 74841 71379 110443068
Sickle cell anaemia with crisis 21.01 12.64 29 74823 9516 110504931
Thrombocytopenia 20.97 12.64 144 74708 348741 110165706
Arteriosclerosis coronary artery 20.95 12.64 50 74802 25068 110489379
Taste disorder 20.93 12.64 9 74843 65378 110449069
Pleural effusion 20.74 12.64 57 74795 177652 110336795
Diabetes mellitus 20.69 12.64 22 74830 99359 110415088
Fluid retention 20.63 12.64 20 74832 94287 110420160
Urinary tract infection 20.45 12.64 133 74719 326149 110188298
Basal ganglia infarction 20.44 12.64 10 74842 730 110513717
Dependence 20.39 12.64 16 74836 2713 110511734
White blood cell count decreased 20.32 12.64 83 74769 229307 110285140
Liver function test increased 20.29 12.64 18 74834 88530 110425917
Chills 20.17 12.64 64 74788 190516 110323931
Cataract 19.65 12.64 15 74837 79470 110434977
Dyspnoea exertional 19.55 12.64 25 74827 104035 110410412
Drug ineffective 19.43 12.64 837 74015 1519703 108994744
Dysarthria 19.40 12.64 110 74742 84011 110430436
Product communication issue 19.39 12.64 15 74837 2491 110511956
Treatment noncompliance 19.24 12.64 99 74753 72891 110441556
Injection site swelling 19.00 12.64 9 74843 61781 110452666
Withdrawal hypertension 18.93 12.64 8 74844 415 110514032
Endotracheal intubation 18.81 12.64 22 74830 6122 110508325
Colitis 18.80 12.64 25 74827 102298 110412149
Brachial artery entrapment syndrome 18.79 12.64 5 74847 59 110514388
Skin exfoliation 18.70 12.64 19 74833 87632 110426815
Lung hyperinflation 18.70 12.64 14 74838 2215 110512232
Eosinophilia 18.50 12.64 8 74844 57928 110456519
Underdose 18.43 12.64 10 74842 63544 110450903
Abdominal distension 18.39 12.64 59 74793 175044 110339403
Thyroxine decreased 18.39 12.64 10 74842 910 110513537
Incorrect route of product administration 18.37 12.64 89 74763 63972 110450475
Rash erythematous 18.32 12.64 17 74835 81815 110432632
Cystitis 18.28 12.64 11 74841 66025 110448422
Injection site bruising 18.17 12.64 6 74846 51257 110463190
Abnormal behaviour 18.17 12.64 63 74789 38976 110475471
Palpitations 17.89 12.64 52 74800 159160 110355287
Lactic acidosis 17.75 12.64 22 74830 92789 110421658
Antemortem blood drug level abnormal 17.74 12.64 5 74847 74 110514373
Pupil fixed 17.54 12.64 17 74835 3821 110510626
Product use in unapproved indication 17.51 12.64 206 74646 447171 110067276
Product quality issue 17.37 12.64 16 74836 77283 110437164
Therapeutic response decreased 17.30 12.64 24 74828 96475 110417972
Nervous system disorder 17.28 12.64 54 74798 31667 110482780
Alanine aminotransferase increased 17.23 12.64 65 74787 183708 110330739
Multiple drug therapy 17.12 12.64 24 74828 7990 110506457
Neurological examination abnormal 17.12 12.64 9 74843 765 110513682
Sudden infant death syndrome 16.96 12.64 7 74845 342 110514105
Drug dependence, antepartum 16.94 12.64 5 74847 88 110514359
Myocardial necrosis 16.84 12.64 8 74844 547 110513900
Sinus bradycardia 16.82 12.64 51 74801 29432 110485015
Microcephaly 16.71 12.64 6 74846 200 110514247
Wrong product administered 16.61 12.64 28 74824 10932 110503515
Ear infection 16.61 12.64 11 74841 62721 110451726
Onychomycosis 16.60 12.64 3 74849 38528 110475919
Chemical submission 16.51 12.64 8 74844 572 110513875
Biliary dilatation 16.46 12.64 16 74836 3609 110510838
Hyperglycaemia 16.45 12.64 20 74832 85070 110429377
Endocarditis 16.22 12.64 31 74821 13340 110501107
Back injury 16.03 12.64 6 74846 47393 110467054
Dehydration 16.00 12.64 117 74735 279394 110235053
Hallucination, visual 15.97 12.64 61 74791 39544 110474903
Transient ischaemic attack 15.91 12.64 12 74840 63970 110450477
Dry eye 15.86 12.64 9 74843 55784 110458663
Epistaxis 15.83 12.64 41 74811 130331 110384116
Gait inability 15.72 12.64 44 74808 136332 110378115
Ventricular extrasystoles 15.67 12.64 42 74810 22599 110491848
Disease recurrence 15.64 12.64 11 74841 60773 110453674
Hypoventilation 15.51 12.64 23 74829 8058 110506389
Bone erosion 15.46 12.64 6 74846 46365 110468082
Anaphylactic reaction 15.42 12.64 34 74818 114266 110400181
Disorientation 15.37 12.64 91 74761 70580 110443867
Fall 15.34 12.64 302 74550 603180 109911267
Weight decreased 15.22 12.64 224 74628 467833 110046614
Hepatitis C RNA 15.20 12.64 4 74848 45 110514402
Pneumocystis jirovecii pneumonia 15.15 12.64 5 74847 42730 110471717
Diffuse alveolar damage 14.98 12.64 16 74836 4031 110510416
Acute kidney injury 14.97 12.64 322 74530 635108 109879339
Thrombosis 14.93 12.64 32 74820 108630 110405817
Mouth ulceration 14.82 12.64 7 74845 48131 110466316
Immunodeficiency 14.76 12.64 4 74848 38834 110475613
Alcohol use 14.74 12.64 16 74836 4106 110510341
Psychomotor retardation 14.70 12.64 22 74830 7770 110506677
Arachnoiditis 14.61 12.64 9 74843 1035 110513412
Blood pressure systolic increased 14.52 12.64 21 74831 82970 110431477
Colitis ischaemic 14.44 12.64 35 74817 17715 110496732
Drug level above therapeutic 14.22 12.64 27 74825 11561 110502886
Thyroid calcification 14.21 12.64 4 74848 59 110514388
International normalised ratio increased 14.18 12.64 23 74829 86749 110427698
Neck pain 13.99 12.64 40 74812 123090 110391357
Pneumonia 13.93 12.64 470 74382 876244 109638203
Symptom masked 13.92 12.64 11 74841 1884 110512563
Electrocardiogram repolarisation abnormality 13.91 12.64 12 74840 2323 110512124
Echolalia 13.90 12.64 7 74845 544 110513903
Oral tuberculosis 13.88 12.64 3 74849 13 110514434
Drug tolerance 13.81 12.64 33 74819 16552 110497895
Haemoglobin decreased 13.81 12.64 105 74747 248622 110265825
Bronchitis 13.79 12.64 57 74795 156975 110357472
Secondary adrenocortical insufficiency 13.78 12.64 16 74836 4418 110510029
Arterial injury 13.78 12.64 8 74844 826 110513621
Myocardial infarction 13.77 12.64 75 74777 192008 110322439
Obstructive airways disorder 13.77 12.64 7 74845 46142 110468305
Presyncope 13.74 12.64 8 74844 48879 110465568
Pyramidal tract syndrome 13.66 12.64 8 74844 839 110513608
Multi-organ disorder 13.65 12.64 14 74838 3367 110511080
Acne 13.62 12.64 3 74849 33517 110480930
Haematuria 13.56 12.64 22 74830 82983 110431464
Abdominal pain 13.56 12.64 255 74597 512734 110001713
Injection site pruritus 13.55 12.64 9 74843 51249 110463198
Pulse absent 13.48 12.64 26 74826 11266 110503181
Gout 13.46 12.64 4 74848 36562 110477885
Pregnancy 13.46 12.64 9 74843 51058 110463389
Blood pressure increased 13.45 12.64 111 74741 258262 110256185
Breakthrough pain 13.45 12.64 10 74842 1566 110512881
Intentional device misuse 13.43 12.64 8 74844 866 110513581
Diabetic wound 13.41 12.64 4 74848 73 110514374
Cluster headache 13.41 12.64 9 74843 1198 110513249
Somnambulism 13.41 12.64 19 74833 6386 110508061
Tongue biting 13.39 12.64 13 74839 2926 110511521
Adverse event 13.38 12.64 34 74818 108775 110405672
Throat irritation 13.37 12.64 10 74842 53542 110460905
Haematoma 13.26 12.64 12 74840 58464 110455983
Mononeuropathy 13.26 12.64 6 74846 367 110514080
Maternal drugs affecting foetus 13.22 12.64 10 74842 1607 110512840
Maternal use of illicit drugs 13.22 12.64 3 74849 17 110514430
Electrocardiogram QRS complex prolonged 13.18 12.64 28 74824 12993 110501454
Menstruation normal 13.17 12.64 4 74848 78 110514369
Sinus disorder 13.16 12.64 3 74849 32725 110481722
Cerebral hypoperfusion 13.10 12.64 8 74844 906 110513541
Factitious disorder 13.06 12.64 5 74847 200 110514247
Blood pressure fluctuation 13.02 12.64 19 74833 74805 110439642
Craniocerebral injury 13.02 12.64 18 74834 5916 110508531
Post-traumatic stress disorder 12.98 12.64 19 74833 6577 110507870
Swollen tongue 12.98 12.64 13 74839 60349 110454098
Bone marrow failure 12.97 12.64 12 74840 57836 110456611
Cerebrovascular accident 12.88 12.64 71 74781 181213 110333234
Detoxification 12.76 12.64 4 74848 87 110514360
Blood urine 12.68 12.64 8 74844 959 110513488
Cholestasis 12.65 12.64 15 74837 64503 110449944
Emotional distress 12.64 12.64 62 74790 44785 110469662

FDA Adverse Event Reporting System (Pediatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Drug withdrawal syndrome neonatal 1078.47 71.15 527 968 1903 110555
Foetal exposure during pregnancy 140.97 71.15 460 1035 15318 97140

Pharmacologic Action:

SourceCodeDescription
ATC N02AC52 NERVOUS SYSTEM
ANALGESICS
OPIOIDS
Diphenylpropylamine derivatives
ATC N07BC02 NERVOUS SYSTEM
OTHER NERVOUS SYSTEM DRUGS
DRUGS USED IN ADDICTIVE DISORDERS
Drugs used in opioid dependence
MeSH PA D000700 Analgesics
MeSH PA D000701 Analgesics, Opioid
MeSH PA D000996 Antitussive Agents
MeSH PA D002492 Central Nervous System Depressants
MeSH PA D009294 Narcotics
MeSH PA D018689 Sensory System Agents
MeSH PA D019141 Respiratory System Agents
CHEBI has role CHEBI:22587 antiviral agent
CHEBI has role CHEBI:35480 analgesic
CHEBI has role CHEBI:35482 opioid analgesic
CHEBI has role CHEBI:35610 antineoplastic agent
CHEBI has role CHEBI:35703 xenobiotic
CHEBI has role CHEBI:50949 serotonin uptake inhibitor
CHEBI has role CHEBI:55322 ฮผ-opioid receptor agonist
CHEBI has role CHEBI:60643 NMDA receptor antagonist
CHEBI has role CHEBI:64946 anti-HIV agent
CHEBI has role CHEBI:78298 environmental contaminant
FDA MoA N0000175684 Full Opioid Agonists
FDA EPC N0000175690 Opioid Agonist

Related Drugs by ATC class:

N02AC Diphenylpropylamine derivatives 4 drugs
bezitramidedextromoramidedextropropoxyphenepiritramide
N07BC Drugs used in opioid dependence 5 drugs
buprenorphinediamorphinelevomethadonelevomethadyl acetatelofexidine

Drug Use | Suggest Off label Use Form| |View source of the data|

DiseaseRelationSNOMED_IDDOID
Severe pain indication 76948002
Opioid withdrawal indication 87132004
Chronic disease of respiratory system contraindication 17097001
Mood swings contraindication 18963009
Inflammatory bowel disease contraindication 24526004 DOID:0050589
Hypercapnia contraindication 29596007
Torsades de pointes contraindication 31722008
Disorder of gallbladder contraindication 39621005 DOID:0060262
Hypothyroidism contraindication 40930008 DOID:1459
Conduction disorder of the heart contraindication 44808001
Low blood pressure contraindication 45007003
Bradycardia contraindication 48867003
Paralytic ileus contraindication 55525008 DOID:8442
Drug AND/OR toxin-induced diarrhea contraindication 65979008
Substance abuse contraindication 66214007
Benign intracranial hypertension contraindication 68267002 DOID:11459
Urethral stricture contraindication 76618002
Decreased respiratory function contraindication 80954004
Injury of head contraindication 82271004
Epilepsy contraindication 84757009 DOID:1826
Kidney disease contraindication 90708001 DOID:557
Prolonged QT interval contraindication 111975006
Acute abdominal pain contraindication 116290004
Procedure on urinary system contraindication 118677009
Disease of liver contraindication 235856003 DOID:409
Benign prostatic hyperplasia contraindication 266569009
Pseudomembranous enterocolitis contraindication 397683000
Congenital long QT syndrome contraindication 442917000
Acute exacerbation of asthma contraindication 708038006




๐Ÿถ Veterinary Drug Use

None

๐Ÿถ Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 8.55 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])		Mechanism
action		Bioact sourceMoA source
Mu-type opioid receptor GPCR AGONIST Ki 8.78 WOMBAT-PK CHEMBL
Potassium voltage-gated channel subfamily H member 2 Ion channel IC50 5.01 CHEMBL
D(3) dopamine receptor GPCR Ki 5.68 CHEMBL
D(4) dopamine receptor GPCR Ki 4.58 CHEMBL
Kappa-type opioid receptor GPCR IC50 6.29 CHEMBL
Glutamate receptor ionotropic, NMDA 3A Ion channel WOMBAT-PK
Neuronal acetylcholine receptor subunit alpha-10 Ion channel WOMBAT-PK
Delta-type opioid receptor GPCR IC50 5.96 CHEMBL
Opioid receptor GPCR IC50 7.29 CHEMBL

External reference:

IDSource
4019820 VUID
N0000147909 NUI
D02102 KEGG_DRUG
1095-90-5 SECONDARY_CAS_RN
4017431 VANDF
4019820 VANDF
C0025605 UMLSCUI
CHEBI:6807 CHEBI
CHEMBL651 ChEMBL_ID
DB00333 DRUGBANK_ID
CHEMBL1200825 ChEMBL_ID
D008691 MESH_DESCRIPTOR_UI
4095 PUBCHEM_CID
5458 IUPHAR_LIGAND_ID
788 INN_ID
UC6VBE7V1Z UNII
218337 RXNORM
1981 MMSL
5065 MMSL
d00050 MMSL
001566 NDDF
004628 NDDF
23883005 SNOMEDCT_US
387286002 SNOMEDCT_US
51758009 SNOMEDCT_US
UC6VBE7V1Z INXIGHT DRUGS

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
Methadone Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 0054-0391 CONCENTRATE 10 mg ORAL ANDA 33 sections
Methadone Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 0054-0392 CONCENTRATE 10 mg ORAL ANDA 33 sections
METHADONE HYDROCHLORIDE HUMAN PRESCRIPTION DRUG LABEL 1 0054-0709 TABLET 5 mg ORAL ANDA 32 sections
METHADONE HYDROCHLORIDE HUMAN PRESCRIPTION DRUG LABEL 1 0054-0710 TABLET 10 mg ORAL ANDA 32 sections
Methadone Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 0054-3553 CONCENTRATE 10 mg ORAL ANDA 31 sections
Methadone Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 0054-3555 SOLUTION 5 mg ORAL ANDA 30 sections
Methadone Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 0054-3555 SOLUTION 5 mg ORAL ANDA 30 sections
Methadone Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 0054-3556 SOLUTION 10 mg ORAL ANDA 30 sections
Methadone Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 0054-3556 SOLUTION 10 mg ORAL ANDA 30 sections
DISKETS HUMAN PRESCRIPTION DRUG LABEL 1 0054-4538 TABLET 40 mg ORAL NDA 31 sections
METHADOSE HUMAN PRESCRIPTION DRUG LABEL 1 0406-0527 CONCENTRATE 10 mg ORAL NDA 33 sections
METHADOSE DISPERSIBLE HUMAN PRESCRIPTION DRUG LABEL 1 0406-0540 TABLET 40 mg ORAL ANDA 33 sections
METHADONE HYDROCHLORIDE HUMAN PRESCRIPTION DRUG LABEL 1 0406-2540 TABLET 40 mg ORAL ANDA 33 sections
Methadone Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 0406-4123 CONCENTRATE 10 mg ORAL ANDA 33 sections
METHADONE HYDROCHLORIDE HUMAN PRESCRIPTION DRUG LABEL 1 0406-5755 TABLET 5 mg ORAL ANDA 34 sections
METHADONE HYDROCHLORIDE HUMAN PRESCRIPTION DRUG LABEL 1 0406-5771 TABLET 10 mg ORAL ANDA 34 sections
METHADONE HYDROCHLORIDE HUMAN PRESCRIPTION DRUG LABEL 1 0406-6221 SOLUTION 10 mg ORAL ANDA 35 sections
METHADONE HYDROCHLORIDE HUMAN PRESCRIPTION DRUG LABEL 1 0406-6225 SOLUTION 5 mg ORAL ANDA 35 sections
METHADOSESUGAR-FREE HUMAN PRESCRIPTION DRUG LABEL 1 0406-8725 CONCENTRATE 10 mg ORAL NDA 33 sections
Methadone Hydrocloridedye-free, sugar-free, unflavored HUMAN PRESCRIPTION DRUG LABEL 1 0527-1927 CONCENTRATE 10 mg ORAL ANDA 28 sections
Methadone Hydrocloridedye-free, sugar-free, unflavored HUMAN PRESCRIPTION DRUG LABEL 1 0527-1927 CONCENTRATE 10 mg ORAL ANDA 28 sections
Methadone Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 0641-6266 INJECTION 10 mg INTRAMUSCULAR ANDA 31 sections
METHADONE HYDROCHLORIDE HUMAN PRESCRIPTION DRUG LABEL 1 0904-7417 TABLET 10 mg ORAL ANDA 32 sections
METHADONE HYDROCHLORIDE HUMAN PRESCRIPTION DRUG LABEL 1 0904-7417 TABLET 10 mg ORAL ANDA 32 sections
Methadone Hydrochloride Human Prescription Drug Label 1 13107-088 TABLET 5 mg ORAL ANDA 32 sections
Methadone Hydrochloride Human Prescription Drug Label 1 13107-089 TABLET 10 mg ORAL ANDA 32 sections
METHADONE HYDROCHLORIDE HUMAN PRESCRIPTION DRUG LABEL 1 16590-689 TABLET 5 mg ORAL NDA 14 sections
Methadone Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 17478-380 INJECTION, SOLUTION 10 mg INTRAMUSCULAR ANDA 31 sections
Methadone Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 17856-0392 CONCENTRATE 10 mg ORAL ANDA 26 sections
METHADOSE HUMAN PRESCRIPTION DRUG LABEL 1 17856-0526 CONCENTRATE 10 mg ORAL NDA 16 sections