Stem definition | Drug id | CAS RN |
---|---|---|
844 | 469-62-5 |
Dose | Unit | Route |
---|---|---|
0.20 | g | O |
0.30 | g | O |
Property | Value | Reference |
---|---|---|
BDDCS (Biopharmaceutical Drug Disposition Classification System) | 2 | Benet LZ, Broccatelli F, Oprea TI |
S (Water solubility) | 0.02 mg/mL | Benet LZ, Broccatelli F, Oprea TI |
MRTD (Maximum Recommended Therapeutic Daily Dose) | 19.15 µM/kg/day | Contrera JF, Matthews EJ, Kruhlak NL, Benz RD |
Vd (Volume of distribution) | 12 L/kg | Lombardo F, Berellini G, Obach RS |
CL (Clearance) | 15 mL/min/kg | Lombardo F, Berellini G, Obach RS |
fu (Fraction unbound in plasma) | 0.24 % | Lombardo F, Berellini G, Obach RS |
t_half (Half-life) | 18 hours | Lombardo F, Berellini G, Obach RS |
Date | Agency | Company | Orphan |
---|---|---|---|
Aug. 16, 1957 | FDA |
MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
---|---|---|---|---|---|---|
Completed suicide | 457.98 | 109.48 | 97 | 212 | 20937 | 2336839 |
Toxicity to various agents | 278.22 | 109.48 | 71 | 238 | 32683 | 2325093 |
Cardio-respiratory arrest | 210.90 | 109.48 | 45 | 264 | 9101 | 2348675 |
Respiratory arrest | 192.06 | 109.48 | 39 | 270 | 6139 | 2351637 |
Cardiac arrest | 178.45 | 109.48 | 43 | 266 | 14887 | 2342889 |
Overdose | 118.28 | 109.48 | 33 | 276 | 19874 | 2337902 |
MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
---|
Source | Code | Description |
---|---|---|
ATC | N02AC04 | NERVOUS SYSTEM ANALGESICS OPIOIDS Diphenylpropylamine derivatives |
ATC | N02AC54 | NERVOUS SYSTEM ANALGESICS OPIOIDS Diphenylpropylamine derivatives |
ATC | N02AC74 | NERVOUS SYSTEM ANALGESICS OPIOIDS Diphenylpropylamine derivatives |
FDA MoA | N0000175684 | Full Opioid Agonists |
FDA EPC | N0000175690 | Opioid Agonist |
MeSH PA | D000700 | Analgesics |
MeSH PA | D000701 | Analgesics, Opioid |
CHEBI has role | CHEBI:35482 | opioid analgesic |
MeSH PA | D002491 | Central Nervous System Agents |
MeSH PA | D002492 | Central Nervous System Depressants |
MeSH PA | D009294 | Narcotics |
MeSH PA | D018373 | Peripheral Nervous System Agents |
MeSH PA | D018689 | Sensory System Agents |
CHEBI has role | CHEBI:55322 | mu-opioid receptor agonist |
Disease | Relation | SNOMED_ID | DOID |
---|---|---|---|
Pain | indication | 22253000 | |
Necrotizing enterocolitis in fetus OR newborn | contraindication | 2707005 | |
Suicidal thoughts | contraindication | 6471006 | |
Alcoholism | contraindication | 7200002 | |
Peptic ulcer | contraindication | 13200003 | DOID:750 |
Chronic obstructive lung disease | contraindication | 13645005 | DOID:3083 |
Alcohol intoxication | contraindication | 25702006 | |
Shock | contraindication | 27942005 | |
Hypovolemia | contraindication | 28560003 | |
Orthostatic hypotension | contraindication | 28651003 | |
Hypercapnia | contraindication | 29596007 | |
Depressive disorder | contraindication | 35489007 | |
Hypertensive disorder | contraindication | 38341003 | DOID:10763 |
Gastrointestinal ulcer | contraindication | 40845000 | |
Conduction disorder of the heart | contraindication | 44808001 | |
Low blood pressure | contraindication | 45007003 | |
Vitamin K deficiency | contraindication | 52675005 | DOID:11249 |
Nasal polyp | contraindication | 52756005 | |
Paralytic ileus | contraindication | 55525008 | DOID:8442 |
Acute nephropathy | contraindication | 58574008 | |
Hepatic failure | contraindication | 59927004 | |
Substance abuse | contraindication | 66214007 | |
Poisoning by acetaminophen | contraindication | 70273001 | |
Agoraphobia | contraindication | 70691001 | DOID:593 |
Factor II deficiency | contraindication | 73975000 | |
Reye's syndrome | contraindication | 74351001 | DOID:14525 |
Gastrointestinal hemorrhage | contraindication | 74474003 | |
Thrombotic thrombocytopenic purpura | contraindication | 78129009 | DOID:10772 |
Decreased respiratory function | contraindication | 80954004 | |
Injury of head | contraindication | 82271004 | |
Cor pulmonale | contraindication | 83291003 | DOID:8515 |
Gout | contraindication | 90560007 | DOID:13189 |
Kidney disease | contraindication | 90708001 | DOID:557 |
Hemophilia | contraindication | 90935002 | |
Disorder of biliary tract | contraindication | 105997008 | DOID:9741 |
Anemia due to enzyme deficiency | contraindication | 111577008 | |
Prolonged QT interval | contraindication | 111975006 | |
von Willebrand disorder | contraindication | 128105004 | DOID:12531 |
Seizure disorder | contraindication | 128613002 | |
Prolonged PR interval | contraindication | 164947007 | |
Obsessive-compulsive disorder | contraindication | 191736004 | DOID:10933 |
Insomnia | contraindication | 193462001 | |
Acute pancreatitis | contraindication | 197456007 | DOID:2913 |
Impaired renal function disorder | contraindication | 197663003 | |
Disease of liver | contraindication | 235856003 | DOID:409 |
Anemia | contraindication | 271737000 | DOID:2355 |
Exacerbation of asthma | contraindication | 281239006 | |
Pregnancy, function | contraindication | 289908002 | |
Thrombocytopenic disorder | contraindication | 302215000 | DOID:1588 |
Panic disorder | contraindication | 371631005 | DOID:594 |
Hypoxia | contraindication | 389086002 | |
Breastfeeding (mother) | contraindication | 413712001 | |
Myocardial ischemia | contraindication | 414795007 | DOID:3393 |
Myocardial infarction in recovery phase | contraindication | 418044006 | |
Central nervous system depression | contraindication | 418072004 | |
Congenital long QT syndrome | contraindication | 442917000 | |
Acute erosive gastritis | contraindication | 444926003 | |
Acute exacerbation of asthma | contraindication | 708038006 |
Dissociation level | Dissociation constant | Type (acidic/basic) |
---|---|---|
pKa1 | 8.26 | Basic |
None
None
Target | Class | Pharos | UniProt | Action | Type | Activity value (-log[M]) | Mechanism action | Bioact source | MoA source |
---|---|---|---|---|---|---|---|---|---|
Mu-type opioid receptor | GPCR | AGONIST | WOMBAT-PK | CHEMBL | |||||
Glutamate receptor ionotropic, NMDA 3A | Ion channel | IC50 | 5.30 | WOMBAT-PK | |||||
Sodium channel protein type 5 subunit alpha | Ion channel | WOMBAT-PK |
ID | Source |
---|---|
4019915 | VUID |
N0000148000 | NUI |
C0033493 | UMLSCUI |
D00482 | KEGG_DRUG |
38M219L1OJ | UNII |
26570-10-5 | SECONDARY_CAS_RN |
387042001 | SNOMEDCT_US |
117005003 | SNOMEDCT_US |
4019915 | VANDF |
8785 | RXNORM |
d00360 | MMSL |
001574 | NDDF |
DB00647 | DRUGBANK_ID |
740 | INN_ID |
CHEBI:51173 | CHEBI |
7593 | IUPHAR_LIGAND_ID |
CHEMBL1213351 | ChEMBL_ID |
CHEMBL1237104 | ChEMBL_ID |
D011431 | MESH_DESCRIPTOR_UI |
CHEMBL3989716 | ChEMBL_ID |
10100 | PUBCHEM_CID |
C084813 | MESH_SUPPLEMENTAL_RECORD_UI |
Product | Category | Ingredients | NDC | Form | Quantity | Route | Marketing | Label |
---|---|---|---|---|---|---|---|---|
PROPOXYPHENE NAPSYLATE AND ACETAMINOPHEN | HUMAN PRESCRIPTION DRUG LABEL | 2 | 12634-537 | TABLET, FILM COATED | 100 mg | ORAL | ANDA | 16 sections |
Propoxyphene | HUMAN PRESCRIPTION DRUG LABEL | 1 | 16590-198 | CAPSULE | 65 mg | ORAL | ANDA | 13 sections |
Darvon-N | HUMAN PRESCRIPTION DRUG LABEL | 1 | 16590-874 | TABLET, FILM COATED | 100 mg | ORAL | NDA | 14 sections |
Propoxyphene Napsylate and Acetaminophen | HUMAN PRESCRIPTION DRUG LABEL | 2 | 21695-280 | TABLET, FILM COATED | 100 mg | ORAL | ANDA | 15 sections |
Propoxyphene and Acetaminophen | HUMAN PRESCRIPTION DRUG LABEL | 2 | 63874-201 | TABLET, FILM COATED | 100 mg | ORAL | ANDA | 17 sections |
PROPOXYPHENE NAPSYLATE AND ACETAMINOPHEN | HUMAN PRESCRIPTION DRUG LABEL | 2 | 67296-0104 | TABLET | 100 mg | ORAL | ANDA | 19 sections |
PROPOXYPHENE NAPSYLATE AND ACETAMINOPHEN | HUMAN PRESCRIPTION DRUG LABEL | 2 | 67296-0105 | TABLET | 100 mg | ORAL | ANDA | 19 sections |
Propoxyphene Napsylate and Acetaminophen | HUMAN PRESCRIPTION DRUG LABEL | 2 | 67296-0378 | TABLET, FILM COATED | 100 mg | ORAL | ANDA | 16 sections |
Propoxyphene and Acetaminophen | HUMAN PRESCRIPTION DRUG LABEL | 2 | 68387-100 | TABLET, FILM COATED | 100 mg | ORAL | ANDA | 17 sections |