Stem definition | Drug id | CAS RN |
---|---|---|
844 | 469-62-5 |
Dose | Unit | Route |
---|---|---|
0.20 | g | O |
0.30 | g | O |
Property | Value | Reference |
---|---|---|
BDDCS (Biopharmaceutical Drug Disposition Classification System) | 2 | Benet LZ, Broccatelli F, Oprea TI |
S (Water solubility) | 0.02 mg/mL | Benet LZ, Broccatelli F, Oprea TI |
MRTD (Maximum Recommended Therapeutic Daily Dose) | 19.15 µM/kg/day | Contrera JF, Matthews EJ, Kruhlak NL, Benz RD |
Vd (Volume of distribution) | 12 L/kg | Lombardo F, Berellini G, Obach RS |
CL (Clearance) | 15 mL/min/kg | Lombardo F, Berellini G, Obach RS |
fu (Fraction unbound in plasma) | 0.24 % | Lombardo F, Berellini G, Obach RS |
t_half (Half-life) | 18 hours | Lombardo F, Berellini G, Obach RS |
Date | Agency | Company | Orphan |
---|---|---|---|
Aug. 16, 1957 | FDA |
MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
---|---|---|---|---|---|---|
Drug hypersensitivity | 1064.70 | 16.54 | 541 | 5339 | 243284 | 46436898 |
Completed suicide | 195.48 | 16.54 | 155 | 5725 | 145765 | 46534417 |
Toxicity to various agents | 145.86 | 16.54 | 155 | 5725 | 211611 | 46468571 |
Injury | 79.26 | 16.54 | 56 | 5824 | 43971 | 46636211 |
Cardio-respiratory arrest | 76.42 | 16.54 | 62 | 5818 | 59807 | 46620375 |
Respiratory arrest | 75.13 | 16.54 | 49 | 5831 | 33767 | 46646415 |
Cardiac arrest | 52.99 | 16.54 | 61 | 5819 | 90338 | 46589844 |
Poisoning | 48.50 | 16.54 | 27 | 5853 | 13967 | 46666215 |
Overdose | 45.52 | 16.54 | 60 | 5820 | 101919 | 46578263 |
Emotional distress | 31.35 | 16.54 | 28 | 5852 | 30679 | 46649503 |
Frontotemporal dementia | 25.28 | 16.54 | 6 | 5874 | 255 | 46679927 |
Spleen congestion | 22.62 | 16.54 | 5 | 5875 | 154 | 46680028 |
Aortic valve calcification | 22.35 | 16.54 | 6 | 5874 | 421 | 46679761 |
Thyroid adenoma | 22.03 | 16.54 | 5 | 5875 | 174 | 46680008 |
Uterine perforation | 19.81 | 16.54 | 12 | 5868 | 7255 | 46672927 |
Sudden death | 19.22 | 16.54 | 13 | 5867 | 9491 | 46670691 |
Poisoning deliberate | 18.85 | 16.54 | 12 | 5868 | 7914 | 46672268 |
Cardiomegaly | 17.95 | 16.54 | 16 | 5864 | 17466 | 46662716 |
Accidental overdose | 17.95 | 16.54 | 17 | 5863 | 20049 | 46660133 |
Drug abuse | 17.73 | 16.54 | 30 | 5850 | 63378 | 46616804 |
Drug screen positive | 17.69 | 16.54 | 9 | 5871 | 3882 | 46676300 |
Dependence | 16.77 | 16.54 | 7 | 5873 | 1924 | 46678258 |
MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
---|---|---|---|---|---|---|
Drug hypersensitivity | 121.80 | 24.63 | 73 | 2346 | 68446 | 29881613 |
Completed suicide | 73.33 | 24.63 | 62 | 2357 | 99430 | 29850629 |
Respiratory arrest | 67.40 | 24.63 | 37 | 2382 | 29221 | 29920838 |
Toxicity to various agents | 64.32 | 24.63 | 75 | 2344 | 177108 | 29772951 |
Poisoning | 58.62 | 24.63 | 25 | 2394 | 11357 | 29938702 |
Drug abuse | 58.06 | 24.63 | 50 | 2369 | 82022 | 29868037 |
Overdose | 49.00 | 24.63 | 46 | 2373 | 84291 | 29865768 |
Cardiac arrest | 48.95 | 24.63 | 48 | 2371 | 92802 | 29857257 |
Accidental overdose | 47.33 | 24.63 | 25 | 2394 | 18250 | 29931809 |
Agoraphobia | 34.25 | 24.63 | 7 | 2412 | 233 | 29949826 |
Cardio-respiratory arrest | 32.73 | 24.63 | 31 | 2388 | 57275 | 29892784 |
Neurosis | 30.68 | 24.63 | 6 | 2413 | 159 | 29949900 |
Somnambulism | 26.79 | 24.63 | 10 | 2409 | 3204 | 29946855 |
Source | Code | Description |
---|---|---|
ATC | N02AC04 | NERVOUS SYSTEM ANALGESICS OPIOIDS Diphenylpropylamine derivatives |
ATC | N02AC54 | NERVOUS SYSTEM ANALGESICS OPIOIDS Diphenylpropylamine derivatives |
ATC | N02AC74 | NERVOUS SYSTEM ANALGESICS OPIOIDS Diphenylpropylamine derivatives |
FDA MoA | N0000175684 | Full Opioid Agonists |
FDA EPC | N0000175690 | Opioid Agonist |
MeSH PA | D000700 | Analgesics |
MeSH PA | D000701 | Analgesics, Opioid |
MeSH PA | D002491 | Central Nervous System Agents |
MeSH PA | D002492 | Central Nervous System Depressants |
MeSH PA | D009294 | Narcotics |
MeSH PA | D018373 | Peripheral Nervous System Agents |
MeSH PA | D018689 | Sensory System Agents |
CHEBI has role | CHEBI:35482 | narcotic analgesics |
CHEBI has role | CHEBI:55322 | mu opioid agonist |
Disease | Relation | SNOMED_ID | DOID |
---|---|---|---|
Pain | indication | 22253000 | |
Necrotizing enterocolitis in fetus OR newborn | contraindication | 2707005 | |
Suicidal thoughts | contraindication | 6471006 | |
Alcoholism | contraindication | 7200002 | |
Peptic ulcer | contraindication | 13200003 | DOID:750 |
Chronic obstructive lung disease | contraindication | 13645005 | DOID:3083 |
Alcohol intoxication | contraindication | 25702006 | |
Shock | contraindication | 27942005 | |
Hypovolemia | contraindication | 28560003 | |
Orthostatic hypotension | contraindication | 28651003 | |
Hypercapnia | contraindication | 29596007 | |
Depressive disorder | contraindication | 35489007 | |
Hypertensive disorder | contraindication | 38341003 | DOID:10763 |
Gastrointestinal ulcer | contraindication | 40845000 | |
Conduction disorder of the heart | contraindication | 44808001 | |
Low blood pressure | contraindication | 45007003 | |
Vitamin K deficiency | contraindication | 52675005 | DOID:11249 |
Nasal polyp | contraindication | 52756005 | |
Paralytic ileus | contraindication | 55525008 | DOID:8442 |
Acute nephropathy | contraindication | 58574008 | |
Hepatic failure | contraindication | 59927004 | |
Substance abuse | contraindication | 66214007 | |
Poisoning by acetaminophen | contraindication | 70273001 | |
Agoraphobia | contraindication | 70691001 | DOID:593 |
Factor II deficiency | contraindication | 73975000 | |
Reye's syndrome | contraindication | 74351001 | DOID:14525 |
Gastrointestinal hemorrhage | contraindication | 74474003 | |
Thrombotic thrombocytopenic purpura | contraindication | 78129009 | DOID:10772 |
Decreased respiratory function | contraindication | 80954004 | |
Injury of head | contraindication | 82271004 | |
Cor pulmonale | contraindication | 83291003 | DOID:8515 |
Gout | contraindication | 90560007 | DOID:13189 |
Kidney disease | contraindication | 90708001 | DOID:557 |
Hemophilia | contraindication | 90935002 | |
Disorder of biliary tract | contraindication | 105997008 | DOID:9741 |
Anemia due to enzyme deficiency | contraindication | 111577008 | |
Prolonged QT interval | contraindication | 111975006 | |
von Willebrand disorder | contraindication | 128105004 | DOID:12531 |
Seizure disorder | contraindication | 128613002 | |
Prolonged PR interval | contraindication | 164947007 | |
Obsessive-compulsive disorder | contraindication | 191736004 | DOID:10933 |
Insomnia | contraindication | 193462001 | |
Acute pancreatitis | contraindication | 197456007 | DOID:2913 |
Impaired renal function disorder | contraindication | 197663003 | |
Disease of liver | contraindication | 235856003 | DOID:409 |
Anemia | contraindication | 271737000 | DOID:2355 |
Exacerbation of asthma | contraindication | 281239006 | |
Pregnancy, function | contraindication | 289908002 | |
Thrombocytopenic disorder | contraindication | 302215000 | DOID:1588 |
Panic disorder | contraindication | 371631005 | DOID:594 |
Hypoxia | contraindication | 389086002 | |
Breastfeeding (mother) | contraindication | 413712001 | |
Myocardial ischemia | contraindication | 414795007 | DOID:3393 |
Myocardial infarction in recovery phase | contraindication | 418044006 | |
Central nervous system depression | contraindication | 418072004 | |
Congenital long QT syndrome | contraindication | 442917000 | |
Acute erosive gastritis | contraindication | 444926003 | |
Acute exacerbation of asthma | contraindication | 708038006 |
Dissociation level | Dissociation constant | Type (acidic/basic) |
---|---|---|
pKa1 | 8.26 | Basic |
None
None
Target | Class | Pharos | UniProt | Action | Type | Activity value (-log[M]) | Mechanism action | Bioact source | MoA source |
---|---|---|---|---|---|---|---|---|---|
Mu-type opioid receptor | GPCR | AGONIST | WOMBAT-PK | CHEMBL | |||||
Glutamate receptor ionotropic, NMDA 3A | Ion channel | IC50 | 5.30 | WOMBAT-PK | |||||
Sodium channel protein type 5 subunit alpha | Ion channel | WOMBAT-PK |
ID | Source |
---|---|
4019915 | VUID |
N0000148000 | NUI |
D00482 | KEGG_DRUG |
1639-60-7 | SECONDARY_CAS_RN |
4017511 | VANDF |
4017512 | VANDF |
4019915 | VANDF |
C0033493 | UMLSCUI |
CHEBI:51173 | CHEBI |
CHEMBL1213351 | ChEMBL_ID |
CHEMBL1237104 | ChEMBL_ID |
CHEMBL3989716 | ChEMBL_ID |
DB00647 | DRUGBANK_ID |
D011431 | MESH_DESCRIPTOR_UI |
10100 | PUBCHEM_CID |
7593 | IUPHAR_LIGAND_ID |
C084813 | MESH_SUPPLEMENTAL_RECORD_UI |
740 | INN_ID |
S2F83W92TK | UNII |
71517 | RXNORM |
2224 | MMSL |
5373 | MMSL |
5374 | MMSL |
d00360 | MMSL |
001574 | NDDF |
001575 | NDDF |
001576 | NDDF |
117005003 | SNOMEDCT_US |
387042001 | SNOMEDCT_US |
56297001 | SNOMEDCT_US |
6837005 | SNOMEDCT_US |
Product | Category | Ingredients | NDC | Form | Quantity | Route | Marketing | Label |
---|---|---|---|---|---|---|---|---|
PROPOXYPHENE NULLPSYLATE AND ACETAMINOPHEN | HUMAN PRESCRIPTION DRUG LABEL | 2 | 12634-537 | TABLET, FILM COATED | 100 mg | ORAL | ANDA | 16 sections |
Propoxyphene | HUMAN PRESCRIPTION DRUG LABEL | 1 | 16590-198 | CAPSULE | 65 mg | ORAL | ANDA | 13 sections |
Darvon-N | HUMAN PRESCRIPTION DRUG LABEL | 1 | 16590-874 | TABLET, FILM COATED | 100 mg | ORAL | NDA | 14 sections |
Propoxyphene Napsylate and Acetaminophen | HUMAN PRESCRIPTION DRUG LABEL | 2 | 21695-280 | TABLET, FILM COATED | 100 mg | ORAL | ANDA | 23 sections |
Propoxyphene and Acetaminophen | HUMAN PRESCRIPTION DRUG LABEL | 2 | 63874-201 | TABLET, FILM COATED | 100 mg | ORAL | ANDA | 29 sections |
PROPOXYPHENE NULLPSYLATE AND ACETAMINOPHEN | HUMAN PRESCRIPTION DRUG LABEL | 2 | 67296-0104 | TABLET | 100 mg | ORAL | ANDA | 19 sections |
PROPOXYPHENE NULLPSYLATE AND ACETAMINOPHEN | HUMAN PRESCRIPTION DRUG LABEL | 2 | 67296-0105 | TABLET | 100 mg | ORAL | ANDA | 19 sections |
Propoxyphene Napsylate and Acetaminophen | HUMAN PRESCRIPTION DRUG LABEL | 2 | 67296-0378 | TABLET, FILM COATED | 100 mg | ORAL | ANDA | 23 sections |
Propoxyphene and Acetaminophen | HUMAN PRESCRIPTION DRUG LABEL | 2 | 68387-100 | TABLET, FILM COATED | 100 mg | ORAL | ANDA | 29 sections |