chlorphenamine 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | PK/Tox | Related Drugs | BioActivity |

Stem definitionDrug idCAS RN
616 132-22-9

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • chlorphenamine
  • chloropheniramine
  • chlorophenylpyridamine
  • chloroprophenpyridamine
  • chlorpheniramine
  • chlorprophenpyridamine
  • chlorpheniramine maleate
  • chlorpheniramine tannate
  • chlorpheniramine polistirex
A histamine H1 antagonist used in allergic reactions, hay fever, rhinitis, urticaria, and asthma. It has also been used in veterinary applications. One of the most widely used of the classical antihistaminics, it generally causes less drowsiness and sedation than PROMETHAZINE.
  • Molecular weight: 274.79
  • Formula: C16H19ClN2
  • CLOGP: 3.15
  • LIPINSKI: 0
  • HAC: 2
  • HDO: 0
  • TPSA: 16.13
  • ALOGS: -3.72
  • ROTB: 5
  • Status: OFP
    • Legend:
    OFP - off patent
    OFM - off market
    ONP - on patent

Drug dosage:

DoseUnitRoute
12 mg O
12 mg P

ADMET properties:

PropertyValueReference
BDDCS (Biopharmaceutical Drug Disposition Classification System) 1 Benet LZ, Broccatelli F, Oprea TI
EoM (Fraction excreted unchanged in urine) 10 % Benet LZ, Broccatelli F, Oprea TI
MRTD (Maximum Recommended Therapeutic Daily Dose) 0.48 µM/kg/day Contrera JF, Matthews EJ, Kruhlak NL, Benz RD
BA (Bioavailability) 41 % Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H
Vd (Volume of distribution) 3.30 L/kg Lombardo F, Berellini G, Obach RS
CL (Clearance) 2.50 mL/min/kg Lombardo F, Berellini G, Obach RS
fu (Fraction unbound in plasma) 0.70 % Lombardo F, Berellini G, Obach RS
t_half (Half-life) 22 hours Lombardo F, Berellini G, Obach RS
S (Water solubility) 3 mg/mL Bocci G, Oprea TI, Benet LZ

Predicted pharmacokinetic/toxicological properties (PK-AZ):

PropertyDescriptionValueUnitConfidenceSimilarity
azlogd74 LogD at pH 7.4 1.549 High 1
caco2-efflux Caco-2 efflux ratio (BA/AB) 0.406 High 1
caco2-intrinsic-papp Caco-2 intrinsic apparent permeability 30.690 10^-6 cm/s High 1
dh-clint Dog hepatocyte intrinsic clearance 29.785 uL/min/10^6 cells High 1
dppb Dog plasma protein binding (% unbound) 46.550 % High 1
fcs-ppb Fetal calf serum protein binding (% unbound) 57.150 % High 1
herg hERG pIC50 5.375 pIC50 High 1
hh-clint Human hepatocyte intrinsic clearance 5.212 uL/min/10^6 cells High 1
hlm-clint Human liver microsomal intrinsic clearance 12.023 uL/min/mg protein High 1
hppb Human plasma protein binding (% unbound) 50.580 % High 1
kinase-safety-class ACVR2A,ACVR2B,AKT1,AKT2,AKT3,AXL,BRAF,BTK,CAMK2B,CAMK2D,CDK4,CDK5,CDK9,CHEK1,DDR1,DYRK1B,EIF2AK3,EPHB4,ERBB2,FLT3,GRK2,ITK,JAK2,JAK3,MAP3K21,MAP3K7,MAPK10,MAPK12,MAPK7,MET,NTRK2,PDK2,PDK4,PDPK1,PIM2,PRKCD,PRKDC,SIK2,SIK3,STK33,SYK,TEK,TGFBR1,TTK 44
kinase-selectivity-class AKT2,AKT3,AXL,EIF2AK3,PDK4,PRKCD,STK33 7
mdck-mdr1-bcrp-efflux MDCK-MDR1-BCRP efflux ratio 0.490 High 1
mdck-mdr1-efflux MDCK-MDR1 efflux ratio 0.306 High 1
mh-clint Mouse hepatocyte intrinsic clearance 87.498 High 1
mppb Mouse plasma protein binding (% unbound) 45.070 High 1
nih-mdck-mdr1-efflux NIH MDCK-MDR1 efflux ratio 1.038 High 1
pfas-class PFAS structural alert (1 = True, 0 = False) 0
pppb Pig plasma protein binding (% unbound) 64.380 % High 1
rat-kpuu-brain Rat brain Kpuu 1.854 % High 1
rh-clint Rat hepatocyte intrinsic clearance 84.528 uL/min/10^6 cells High 1
rh-fuinc Rat hepatocyte fraction unbound in incubation 75.300 % High 1
rppb Rat plasma protein binding (% unbound) 51.960 % High 1
solubility-dd Solubility at pH 7.4 in DMSO 950.605 uM High 1

Approvals:

DateAgencyCompanyOrphan
Aug. 15, 1950 FDA BAYER HEALTHCARE LLC

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Drug ineffective 241.77 9.21 718 95683 1383580 89148466
Chest discomfort 143.45 9.21 396 96005 137969 90394077
Drug intolerance 136.76 9.21 165 96236 447426 90084620
Contraindicated product administered 133.78 9.21 88 96313 320051 90211995
Dyspnoea 110.64 9.21 1425 94976 879530 89652516
Treatment failure 109.78 9.21 97 96304 303831 90228215
Cough 105.69 9.21 713 95688 368249 90163797
Neuropathy peripheral 99.17 9.21 346 96055 136624 90395422
Therapeutic product effect decreased 90.48 9.21 97 96304 277474 90254572
Pemphigus 89.06 9.21 131 96270 326733 90205313
Maternal exposure during pregnancy 88.05 9.21 155 96246 359908 90172138
Synovitis 78.78 9.21 144 96257 329608 90202438
Arthropathy 73.17 9.21 177 96224 366065 90165981
Glossodynia 72.08 9.21 146 96255 321633 90210413
Systemic lupus erythematosus 69.87 9.21 178 96223 361718 90170328
Hand deformity 69.38 9.21 131 96270 296231 90235815
Sinusitis 69.14 9.21 611 95790 342477 90189569
Flushing 67.93 9.21 228 96173 88263 90443783
Asthma 65.71 9.21 462 95939 241698 90290348
Joint swelling 59.03 9.21 305 96096 502995 90029051
Sinusitis fungal 57.42 9.21 32 96369 1932 90530114
Anaphylactic reaction 57.29 9.21 214 96187 87310 90444736
Anti-cyclic citrullinated peptide antibody positive 56.66 9.21 103 96298 236330 90295716
Neutropenic sepsis 54.55 9.21 81 96320 18049 90513997
Ejection fraction decreased 54.25 9.21 99 96302 26154 90505892
Pericarditis 53.58 9.21 131 96270 270020 90262026
Anxiety 53.54 9.21 534 95867 309238 90222808
Diarrhoea 52.83 9.21 1339 95062 937851 89594195
Nausea 51.77 9.21 1545 94856 1108771 89423275
Hepatic enzyme increased 48.50 9.21 208 96193 360528 90171518
Off label use 48.34 9.21 854 95547 1101398 89430648
Chest pain 48.18 9.21 536 95865 319109 90212937
Completed suicide 48.01 9.21 50 96351 145008 90387038
Sputum increased 47.72 9.21 33 96368 2924 90529122
Back pain 47.41 9.21 531 95870 316644 90215402
Salpingo-oophorectomy unilateral 46.39 9.21 22 96379 946 90531100
Wound 45.61 9.21 167 96234 302813 90229233
Rheumatoid arthritis 45.21 9.21 215 96186 362399 90169647
Abdominal discomfort 44.00 9.21 312 96089 477016 90055030
Nasal congestion 42.70 9.21 189 96212 83225 90448821
Deep vein thrombosis 42.02 9.21 201 96200 91419 90440627
Excessive eye blinking 41.88 9.21 23 96378 1349 90530697
Infective pulmonary exacerbation of cystic fibrosis 41.60 9.21 53 96348 10226 90521820
Diverticulum 40.66 9.21 57 96344 12056 90519990
Sleep apnoea syndrome 38.09 9.21 96 96305 31651 90500395
Eosinophilic colitis 37.63 9.21 13 96388 241 90531805
Pulmonary embolism 37.47 9.21 253 96148 130567 90401479
Rheumatoid factor positive 37.46 9.21 79 96322 171571 90360475
Therapeutic product effect incomplete 35.39 9.21 98 96303 193798 90338248
Throat tightness 35.21 9.21 89 96312 29395 90502651
Emotional distress 35.09 9.21 102 96299 36560 90495486
Palpitations 34.82 9.21 257 96144 136471 90395575
Headache 34.46 9.21 1179 95222 861567 89670479
Listless 34.04 9.21 28 96373 3221 90528825
Myelosuppression 33.31 9.21 8 96393 53583 90478463
Musculoskeletal stiffness 32.88 9.21 183 96218 296349 90235697
Swelling face 32.73 9.21 172 96229 81180 90450866
Duodenal ulcer perforation 31.97 9.21 124 96277 221164 90310882
Vertigo 31.89 9.21 153 96248 69658 90462388
Bronchospasm 31.82 9.21 69 96332 20640 90511406
Oropharyngeal pain 31.34 9.21 220 96181 114967 90417079
Product use issue 31.18 9.21 214 96187 329705 90202341
Reduced facial expression 31.02 9.21 24 96377 2529 90529517
Candida infection 30.93 9.21 93 96308 33964 90498082
Toxicity to various agents 30.11 9.21 181 96220 287665 90244381
Gallbladder polyp 28.88 9.21 16 96385 955 90531091
Urinary tract infection 28.82 9.21 471 95930 305161 90226885
Nail infection 28.71 9.21 23 96378 2549 90529497
Diastolic dysfunction 28.41 9.21 37 96364 7296 90524750
Chronic obstructive pulmonary disease 28.27 9.21 154 96247 73675 90458371
C-reactive protein increased 27.93 9.21 99 96302 181290 90350756
Discomfort 27.92 9.21 174 96227 274161 90257885
Drug interaction 27.79 9.21 176 96225 276277 90255769
Foetal exposure during pregnancy 27.54 9.21 6 96395 42969 90489077
Embolism venous 27.51 9.21 26 96375 3594 90528452
Hiccups 27.44 9.21 24 96377 3002 90529044
Helicobacter infection 27.38 9.21 136 96265 226714 90305332
General physical health deterioration 26.76 9.21 245 96156 354870 90177176
Dilatation intrahepatic duct acquired 26.60 9.21 14 96387 754 90531292
Bronchitis 26.56 9.21 264 96137 152663 90379383
Myalgia 26.50 9.21 294 96107 174831 90357215
Vulvovaginal candidiasis 25.87 9.21 26 96375 3874 90528172
Oxygen saturation decreased 25.66 9.21 199 96202 107284 90424762
Dizziness 25.18 9.21 812 95589 588472 89943574
Infusion site erythema 25.08 9.21 49 96352 13621 90518425
Lip swelling 24.92 9.21 94 96307 38516 90493530
Iron deficiency anaemia 24.76 9.21 68 96333 23594 90508452
Condition aggravated 24.54 9.21 466 95935 595079 89936967
Swelling 24.37 9.21 307 96094 418751 90113295
Therapy non-responder 24.27 9.21 70 96331 136634 90395412
Emphysema 24.06 9.21 45 96356 12110 90519936
Mucosal inflammation 23.98 9.21 123 96278 57502 90474544
Arthralgia 23.90 9.21 638 95763 777884 89754162
Delusion of replacement 23.74 9.21 6 96395 34 90532012
Acute respiratory failure 23.30 9.21 99 96302 42819 90489227
Apathy 23.27 9.21 42 96359 10998 90521048
Neutropenia 23.24 9.21 352 96049 224552 90307494
Hypoxia 23.16 9.21 144 96257 72255 90459791
Rhinorrhoea 22.48 9.21 166 96235 88150 90443896
Constipation 22.45 9.21 421 95980 279974 90252072
Feeling hot 22.41 9.21 151 96250 77857 90454189
Respiratory symptom 22.27 9.21 25 96376 4227 90527819
Premature delivery 21.82 9.21 7 96394 38755 90493291
Tricuspid valve incompetence 21.56 9.21 52 96349 16679 90515367
Nasal discomfort 21.50 9.21 28 96373 5520 90526526
Tonsillar hypertrophy 21.11 9.21 14 96387 1158 90530888
Band sensation 21.10 9.21 14 96387 1159 90530887
Pneumonia 21.07 9.21 854 95547 637205 89894841
Foreign body 21.06 9.21 19 96382 2475 90529571
Lacrimation increased 21.00 9.21 70 96331 26992 90505054
Acute kidney injury 20.82 9.21 229 96172 320158 90211888
Acute sinusitis 20.54 9.21 24 96377 4237 90527809
Necrotic lymphadenopathy 20.50 9.21 7 96394 125 90531921
Poor quality device used 20.42 9.21 18 96383 2275 90529771
Agranulocytosis 20.28 9.21 6 96395 34996 90497050
Seasonal allergy 20.15 9.21 62 96339 22921 90509125
Retinal detachment 19.84 9.21 30 96371 6792 90525254
Red blood cell sedimentation rate increased 19.75 9.21 36 96365 82559 90449487
Hip arthroplasty 19.33 9.21 32 96369 76176 90455870
Upper respiratory tract infection 19.21 9.21 215 96186 128103 90403943
Chemical burns of eye 19.19 9.21 6 96395 80 90531966
Hiatus hernia 19.15 9.21 65 96336 25296 90506750
Blister infected 19.14 9.21 12 96389 901 90531145
Hepatocellular injury 18.64 9.21 4 96397 28954 90503092
Muscle injury 18.51 9.21 111 96290 176543 90355503
Vascular compression 18.43 9.21 8 96393 279 90531767
Hyperlipidaemia 18.43 9.21 60 96341 22856 90509190
Catheter site bruise 18.41 9.21 10 96391 574 90531472
Alopecia 18.40 9.21 394 96007 494677 90037369
Sinus disorder 18.34 9.21 79 96322 34368 90497678
Rhinitis allergic 18.33 9.21 49 96352 16736 90515310
Biliary sepsis 18.30 9.21 12 96389 974 90531072
Liver injury 17.96 9.21 107 96294 170460 90361586
Atrial fibrillation 17.85 9.21 219 96182 133392 90398654
Diverticulitis 17.80 9.21 95 96306 45092 90486954
Rheumatic fever 17.78 9.21 93 96308 153028 90379018
Drug reaction with eosinophilia and systemic symptoms 17.50 9.21 12 96389 42746 90489300
Psoriatic arthropathy 17.42 9.21 157 96244 228178 90303868
C-reactive protein abnormal 17.39 9.21 73 96328 127356 90404690
Malignant neoplasm progression 17.35 9.21 57 96344 106813 90425233
Head discomfort 17.15 9.21 47 96354 16286 90515760
Multi-organ disorder 17.10 9.21 16 96385 2184 90529862
Pain in jaw 16.98 9.21 98 96303 47887 90484159
Adverse event 16.82 9.21 66 96335 117352 90414694
Tachycardia 16.76 9.21 248 96153 157425 90374621
Sopor 16.71 9.21 3 96398 24641 90507405
Polyglandular disorder 16.61 9.21 7 96394 227 90531819
Cholecystitis chronic 16.56 9.21 34 96367 9792 90522254
Muscle spasms 16.45 9.21 367 96034 251516 90280530
Nasal polyps 16.43 9.21 36 96365 10844 90521202
Flatulence 16.32 9.21 87 96314 41280 90490766
Infusion site nodule 16.30 9.21 14 96387 1709 90530337
Drug resistance 16.28 9.21 6 96395 30443 90501603
Erythema 16.25 9.21 338 96063 228908 90303138
Lethargy 16.25 9.21 119 96282 63020 90469026
Rhinitis 16.24 9.21 41 96360 13531 90518515
Drug tolerance decreased 16.08 9.21 7 96394 32123 90499923
Hysterectomy 16.01 9.21 37 96364 11547 90520499
Infusion site swelling 15.72 9.21 37 96364 11683 90520363
Mood swings 15.58 9.21 53 96348 20649 90511397
Vestibular neuronitis 15.50 9.21 10 96391 789 90531257
Folliculitis 15.37 9.21 141 96260 204212 90327834
Acute interstitial pneumonitis 15.28 9.21 10 96391 809 90531237
Panic attack 15.24 9.21 62 96339 26303 90505743
Mobility decreased 15.19 9.21 182 96219 250552 90281494
Prescription drug used without a prescription 15.14 9.21 18 96383 3237 90528809
Macular degeneration 15.09 9.21 11 96390 37959 90494087
Product dose omission issue 14.88 9.21 411 95990 291276 90240770
Ventricular extrasystoles 14.79 9.21 39 96362 13211 90518835
Confusional arousal 14.74 9.21 7 96394 302 90531744
Presyncope 14.74 9.21 70 96331 31735 90500311
Infusion site pruritus 14.60 9.21 26 96375 6739 90525307
Essential hypertension 14.57 9.21 25 96376 6290 90525756
Impaired healing 14.57 9.21 169 96232 234030 90298016
Pain 14.55 9.21 890 95511 995451 89536595
Abdominal pain 14.53 9.21 536 95865 395185 90136861
Retching 14.37 9.21 49 96352 19110 90512936
Prescribed underdose 14.37 9.21 37 96364 74982 90457064
Nasal turbinate hypertrophy 14.21 9.21 10 96391 911 90531135
Sinus tachycardia 14.13 9.21 64 96337 28449 90503597
Lactic acidosis 13.94 9.21 20 96381 50443 90481603
Swollen joint count increased 13.79 9.21 66 96335 111140 90420906
Intentional product use issue 13.69 9.21 156 96245 216736 90315310
Hypervolaemia 13.68 9.21 70 96331 32687 90499359
Neuralgia 13.64 9.21 68 96333 31432 90500614
Terminal ileitis 13.57 9.21 11 96390 1239 90530807
Vision blurred 13.54 9.21 178 96223 110115 90421931
Tubulointerstitial nephritis 13.54 9.21 5 96396 25338 90506708
Inflammation 13.53 9.21 123 96278 178469 90353577
Haemodialysis complication 13.52 9.21 6 96395 221 90531825
Drug ineffective for unapproved indication 13.45 9.21 32 96369 66612 90465434
Multiple allergies 13.41 9.21 41 96360 15105 90516941
Oedema peripheral 13.32 9.21 364 96037 257551 90274495
Pyrexia 13.29 9.21 843 95558 659642 89872404
Blister 13.28 9.21 191 96210 254807 90277239
Transient ischaemic attack 13.26 9.21 85 96316 43091 90488955
Hyperkalaemia 13.26 9.21 31 96370 64933 90467113
Swollen tongue 13.22 9.21 89 96312 45867 90486179
Laryngospasm 13.20 9.21 17 96384 3316 90528730
Irritable bowel syndrome 13.18 9.21 149 96252 207299 90324747
Drug hypersensitivity 13.14 9.21 384 96017 463225 90068821
Biliary dyskinesia 13.13 9.21 15 96386 2584 90529462
Anhedonia 13.12 9.21 34 96367 11397 90520649
Anosmia 13.11 9.21 31 96370 9817 90522229
Cyanosis 13.08 9.21 48 96353 19407 90512639
Knee arthroplasty 13.07 9.21 45 96356 83137 90448909
Ageusia 12.84 9.21 42 96359 16034 90516012
Obstructive airways disorder 12.77 9.21 58 96343 25811 90506235
Axillary pain 12.76 9.21 14 96387 2307 90529739
Disease recurrence 12.74 9.21 76 96325 37577 90494469
Cholestasis 12.59 9.21 12 96389 36287 90495759
Peripheral pulse decreased 12.55 9.21 4 96397 57 90531989
Dyspnoea at rest 12.44 9.21 20 96381 4771 90527275
Sleep disorder due to general medical condition, insomnia type 12.38 9.21 83 96318 128611 90403435
Therapy partial responder 12.38 9.21 4 96397 22039 90510007
Coma 12.30 9.21 38 96363 72594 90459452
Chronic hepatitis 12.27 9.21 10 96391 1135 90530911
Bronchial haemorrhage 12.25 9.21 8 96393 645 90531401
Chronic sinusitis 12.23 9.21 54 96347 23748 90508298
Incorrect dose administered 12.16 9.21 133 96268 78797 90453249
Poor peripheral circulation 12.13 9.21 18 96383 4007 90528039
Type 2 diabetes mellitus 12.13 9.21 148 96253 203096 90328950
Gastrooesophageal reflux disease 12.03 9.21 246 96155 166091 90365955
Diffuse large B-cell lymphoma refractory 11.94 9.21 12 96389 1788 90530258
Neutropenic infection 11.89 9.21 12 96389 1797 90530249
Premature baby 11.73 9.21 6 96395 25071 90506975
Administration site extravasation 11.65 9.21 10 96391 1220 90530826
Pulmonary fibrosis 11.55 9.21 67 96334 107436 90424610
Tinnitus 11.53 9.21 82 96319 43020 90489026
Sedation 11.51 9.21 21 96380 48150 90483896
Low turnover osteopathy 11.49 9.21 18 96383 4200 90527846
Pelvic fracture 11.48 9.21 39 96362 15180 90516866
Coronary artery disease 11.46 9.21 68 96333 33555 90498491
Cellulitis 11.46 9.21 148 96253 91189 90440857
Gastrointestinal disorder 11.44 9.21 198 96203 256489 90275557
Gastroenteritis viral 11.40 9.21 63 96338 30292 90501754
Victim of chemical submission 11.35 9.21 8 96393 731 90531315
Autoimmune haemolytic anaemia 11.30 9.21 21 96380 5624 90526422
Product use in unapproved indication 11.23 9.21 272 96129 335964 90196082
Bronchial neoplasm 11.20 9.21 7 96394 523 90531523
Toxic encephalopathy 11.17 9.21 27 96374 8672 90523374
Blood cholesterol increased 11.12 9.21 155 96246 207857 90324189
Haemorrhoids 11.11 9.21 57 96344 26645 90505401
Oral pain 11.08 9.21 66 96335 32617 90499429
Nail dystrophy 11.05 9.21 10 96391 1308 90530738
Abnormal sensation in eye 11.03 9.21 12 96389 1959 90530087
Prosopagnosia 11.03 9.21 4 96397 86 90531960
Anaemia folate deficiency 11.01 9.21 7 96394 539 90531507
Gallbladder disorder 11.00 9.21 46 96355 19757 90512289
Necrotising colitis 10.92 9.21 10 96391 1328 90530718
Periorbital oedema 10.84 9.21 23 96378 6776 90525270
Irritability 10.83 9.21 70 96331 35592 90496454
Impaired quality of life 10.77 9.21 51 96350 23093 90508953
Depression 10.75 9.21 406 95995 300195 90231851
Cytomegalovirus test positive 10.74 9.21 16 96385 3575 90528471
Epilepsy 10.66 9.21 48 96353 82158 90449888
Pulmonary function test decreased 10.65 9.21 18 96383 4476 90527570
Viral infection 10.62 9.21 78 96323 41336 90490710
Product quality issue 10.58 9.21 130 96271 79195 90452851
Nasal herpes 10.55 9.21 8 96393 818 90531228
Faeces hard 10.50 9.21 15 96386 3227 90528819
Catheter site haemorrhage 10.48 9.21 16 96385 3652 90528394
Pancreatitis chronic 10.48 9.21 14 96387 2829 90529217
Sinus headache 10.44 9.21 22 96379 6454 90525592
Eosinophilia 10.41 9.21 9 96392 28524 90503522
Cardiac failure congestive 10.39 9.21 155 96246 98539 90433507
Adverse drug reaction 10.37 9.21 77 96324 116624 90415422
Wheezing 10.37 9.21 329 96072 237751 90294295
Food allergy 10.33 9.21 54 96347 25424 90506622
Appendicitis 10.31 9.21 29 96372 10202 90521844
Urticaria 10.15 9.21 418 95983 312316 90219730
Aerophagia 10.12 9.21 3 96398 33 90532013
Stomatitis 10.07 9.21 219 96182 274479 90257567
Escherichia urinary tract infection 10.07 9.21 35 96366 13780 90518266
Exercise test abnormal 10.04 9.21 4 96397 112 90531934
Polyneuropathy 10.02 9.21 4 96397 19337 90512709
Hyperhidrosis 9.99 9.21 202 96199 136103 90395943
Rhonchi 9.97 9.21 14 96387 2964 90529082
Plantar fasciitis 9.97 9.21 17 96384 4257 90527789
Body mass index increased 9.97 9.21 10 96391 1487 90530559
Blood magnesium decreased 9.96 9.21 38 96363 15655 90516391
Hypoacusis 9.93 9.21 57 96344 27793 90504253
Blood pressure fluctuation 9.92 9.21 26 96375 52387 90479659
Vitamin D deficiency 9.92 9.21 41 96360 17515 90514531
Nystagmus 9.90 9.21 23 96378 7204 90524842
Hyperpyrexia 9.89 9.21 18 96383 4743 90527303
Hereditary angioedema 9.89 9.21 27 96374 9338 90522708
Haemoptysis 9.87 9.21 65 96336 33255 90498791
Joint stiffness 9.86 9.21 46 96355 77996 90454050
Transferrin saturation decreased 9.86 9.21 8 96393 903 90531143
Intentional self-injury 9.83 9.21 10 96391 29324 90502722
Febrile neutropenia 9.80 9.21 229 96172 158120 90373926
Grip strength decreased 9.78 9.21 58 96343 92518 90439528
Pulmonary hypertension 9.74 9.21 78 96323 42445 90489601
Infusion site bruising 9.69 9.21 17 96384 4355 90527691
Actinic elastosis 9.67 9.21 3 96398 39 90532007
Urinary retention 9.63 9.21 71 96330 37673 90494373
Therapeutic response decreased 9.59 9.21 56 96345 89673 90442373
Obstructive defaecation 9.57 9.21 5 96396 265 90531781
Eosinophilic myocarditis 9.57 9.21 7 96394 678 90531368
Dermatitis contact 9.53 9.21 34 96367 13561 90518485
Osteopenia 9.50 9.21 49 96352 22953 90509093
Intervertebral disc degeneration 9.49 9.21 40 96361 17234 90514812
Endocrine disorder 9.49 9.21 8 96393 952 90531094
Hypoaesthesia eye 9.48 9.21 6 96395 458 90531588
Immobile 9.47 9.21 21 96380 6377 90525669
Exposure during pregnancy 9.35 9.21 188 96213 238222 90293824
Tidal volume decreased 9.33 9.21 3 96398 44 90532002
Stoma site dermatitis 9.30 9.21 5 96396 281 90531765
Urethral stenosis 9.25 9.21 5 96396 284 90531762
Anal incontinence 9.25 9.21 38 96363 16192 90515854

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Delusion of grandeur 110.50 11.26 50 44917 1946 42574422
Rhinalgia 101.47 11.26 46 44921 1798 42574570
Lower respiratory tract infection 96.05 11.26 163 44804 41043 42535325
Drug ineffective 86.94 11.26 357 44610 629840 41946528
Lymphocyte count abnormal 85.11 11.26 43 44924 2144 42574224
Affective disorder 79.41 11.26 59 44908 5901 42570467
Upper respiratory tract infection 57.22 11.26 133 44834 42040 42534328
Schizophrenia 50.56 11.26 59 44908 10491 42565877
Asthma 49.94 11.26 162 44805 62152 42514216
Sinusitis 48.36 11.26 134 44833 47158 42529210
SARS-CoV-2 test positive 46.09 11.26 50 44917 8210 42568158
Drug therapy 38.03 11.26 40 44927 6340 42570028
Analgesic therapy 37.29 11.26 40 44927 6484 42569884
Sleep disorder therapy 37.19 11.26 41 44926 6853 42569515
Painful respiration 36.66 11.26 21 44946 1348 42575020
Hyperphosphataemia 36.51 11.26 56 44911 12948 42563420
Urticaria 35.10 11.26 163 44804 73873 42502495
Neuralgia 34.90 11.26 81 44886 25566 42550802
Dyspepsia 34.48 11.26 109 44858 41243 42535125
Cellulitis 34.06 11.26 142 44825 61443 42514925
Acute kidney injury 33.76 11.26 238 44729 367099 42209269
Chest injury 33.55 11.26 22 44945 1800 42574568
Infective pulmonary exacerbation of cystic fibrosis 33.01 11.26 41 44926 7777 42568591
Hypophosphataemia 31.69 11.26 69 44898 20876 42555492
Constipation 31.58 11.26 285 44682 162006 42414362
Bronchopulmonary aspergillosis allergic 31.36 11.26 31 44936 4567 42571801
Drug interaction 31.36 11.26 160 44807 266839 42309529
Alopecia 29.96 11.26 83 44884 29193 42547175
Anticoagulant therapy 29.87 11.26 30 44937 4505 42571863
Flushing 29.42 11.26 96 44871 36932 42539436
Lactic acidosis 29.33 11.26 6 44961 45255 42531113
Dyspnoea 29.03 11.26 640 44327 441981 42134387
Antacid therapy 28.88 11.26 30 44937 4687 42571681
Treatment failure 28.86 11.26 15 44952 62609 42513759
Drug hypersensitivity 28.48 11.26 191 44776 99198 42477170
Extrapyramidal disorder 28.25 11.26 57 44910 16355 42560013
Infusion related reaction 28.17 11.26 133 44834 60673 42515695
Lip swelling 27.95 11.26 62 44905 18991 42557377
Myasthenia gravis 27.72 11.26 56 44911 16081 42560287
Neutropenic sepsis 26.99 11.26 55 44912 15891 42560477
Renal failure 26.83 11.26 71 44896 143655 42432713
Stress 26.07 11.26 104 44863 44108 42532260
Therapeutic product effect incomplete 25.94 11.26 22 44945 70917 42505451
Drug resistance 25.68 11.26 3 44964 34245 42542123
Congenital hiatus hernia 25.46 11.26 32 44935 6142 42570226
Hallucination, auditory 24.84 11.26 51 44916 14813 42561555
Gout 24.35 11.26 75 44892 27980 42548388
Fatigue 24.29 11.26 616 44351 435025 42141343
Walking aid user 24.26 11.26 21 44946 2612 42573756
Failure to anastomose 24.11 11.26 9 44958 212 42576156
Pleuritic pain 23.51 11.26 33 44934 7044 42569324
Myelosuppression 23.05 11.26 7 44960 40454 42535914
Cough 23 11.26 288 44679 177815 42398553
Death 22.81 11.26 355 44612 470830 42105538
Neutrophil count increased 21.11 11.26 57 44910 19747 42556621
Pyrexia 21.02 11.26 554 44413 393488 42182880
Chronic obstructive pulmonary disease 20.99 11.26 126 44841 62988 42513380
Oropharyngeal blistering 20.84 11.26 8 44959 204 42576164
Hyperkalaemia 20.74 11.26 33 44934 80425 42495943
Off label use 20.59 11.26 515 44452 637820 41938548
Dry mouth 20.53 11.26 90 44877 39789 42536579
Troponin increased 20.46 11.26 55 44912 19007 42557361
Blood calcium increased 20.42 11.26 34 44933 8420 42567948
Interstitial lung disease 20.39 11.26 32 44935 78430 42497938
Ear infection 20.31 11.26 43 44924 12761 42563607
Hyperlipidaemia 20.07 11.26 59 44908 21457 42554911
Swelling 19.82 11.26 112 44855 54773 42521595
Personality change 19.50 11.26 27 44940 5692 42570676
Sleep disorder 19.30 11.26 101 44866 47994 42528374
Pulmonary embolism 19.29 11.26 202 44765 119410 42456958
Incorrect route of product administration 19.29 11.26 63 44904 24242 42552126
Bronchitis 18.85 11.26 99 44868 47102 42529266
Hypersomnia 18.62 11.26 45 44922 14573 42561795
Hypoacusis 18.13 11.26 52 44915 18650 42557718
Feeling cold 17.68 11.26 41 44926 12932 42563436
Neutropenic infection 17.38 11.26 15 44952 1858 42574510
Contraindicated product administered 17.12 11.26 3 44964 25269 42551099
Pneumonia 16.68 11.26 572 44395 421577 42154791
Neuropathy peripheral 16.41 11.26 172 44795 101681 42474687
Malignant neoplasm progression 16.35 11.26 59 44908 108341 42468027
Abnormal behaviour 16.22 11.26 63 44904 26388 42549980
Benign prostatic hyperplasia 16.20 11.26 54 44913 20998 42555370
Drug ineffective for unapproved indication 16.05 11.26 15 44952 46148 42530220
Intentional product misuse 15.98 11.26 116 44851 61784 42514584
Renal impairment 15.97 11.26 61 44906 110167 42466201
Toxic epidermal necrolysis 15.83 11.26 63 44904 26687 42549681
Tonsillitis 15.75 11.26 17 44950 2774 42573594
Rhabdomyolysis 15.75 11.26 37 44930 77982 42498386
Bronchospasm 15.70 11.26 39 44928 12846 42563522
Nasal congestion 15.51 11.26 67 44900 29434 42546934
Nasal discomfort 15.36 11.26 13 44954 1569 42574799
Febrile neutropenia 15.27 11.26 278 44689 185425 42390943
Lymphocyte count decreased 15.27 11.26 64 44903 27745 42548623
Activated partial thromboplastin time prolonged 15.21 11.26 44 44923 15859 42560509
Bacterial infection 15.18 11.26 64 44903 27815 42548553
Chills 14.76 11.26 158 44809 93908 42482460
Coma 14.73 11.26 21 44946 53533 42522835
Bradycardia 14.63 11.26 44 44923 85440 42490928
Foetal exposure during pregnancy 14.62 11.26 17 44950 47294 42529074
Rheumatoid arthritis 14.51 11.26 14 44953 42426 42533942
Rhinitis allergic 14.41 11.26 19 44948 3823 42572545
Cystic fibrosis 14.28 11.26 14 44953 2041 42574327
Incorrect dose administered 14.09 11.26 100 44867 52874 42523494
Tremor 13.92 11.26 160 44807 96769 42479599
Oral candidiasis 13.91 11.26 40 44927 14365 42562003
HIV associated nephropathy 13.89 11.26 7 44960 347 42576021
Seasonal allergy 13.89 11.26 28 44939 8027 42568341
Aspiration 13.87 11.26 46 44921 17840 42558528
Blood test abnormal 13.61 11.26 37 44930 12869 42563499
Hyponatraemia 13.48 11.26 165 44802 101297 42475071
Lethargy 13.35 11.26 90 44877 46800 42529568
Swelling face 13.29 11.26 61 44906 27493 42548875
Dyspnoea paroxysmal nocturnal 13.10 11.26 12 44955 1608 42574760
Breath sounds abnormal 13.08 11.26 35 44932 12058 42564310
Pancreatitis acute 12.77 11.26 10 44957 33554 42542814
Sputum discoloured 12.70 11.26 31 44936 10101 42566267
Hypoxic-ischaemic encephalopathy 12.67 11.26 21 44946 5181 42571187
Limb mass 12.63 11.26 9 44958 843 42575525
Micturition urgency 12.44 11.26 34 44933 11864 42564504
Blood phosphorus increased 12.31 11.26 35 44932 12490 42563878
Dry skin 12.14 11.26 90 44877 48248 42528120
Wheezing 12.10 11.26 99 44868 54682 42521686
Cardiovascular disorder 11.85 11.26 36 44931 13329 42563039
Ulcer 11.62 11.26 41 44926 16400 42559968
Sinus disorder 11.59 11.26 26 44941 8024 42568344
Rhinorrhoea 11.56 11.26 65 44902 31729 42544639
Accidental exposure to product by child 11.50 11.26 11 44956 1556 42574812

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Drug ineffective 258.39 9.46 804 117419 1519736 108951340
Chest discomfort 119.34 9.46 433 117790 173415 110297661
Dyspnoea 117.90 9.46 1746 116477 1105126 109365950
Neuropathy peripheral 116.76 9.46 439 117784 178838 110292238
Delusion of grandeur 103.92 9.46 50 118173 2210 110468866
Contraindicated product administered 99.63 9.46 72 118151 248195 110222881
Cough 97.07 9.46 833 117390 460808 110010268
Treatment failure 94.60 9.46 94 118129 277140 110193936
Flushing 88.73 9.46 280 117943 104456 110366620
Rhinalgia 80.54 9.46 51 118172 3878 110467198
Lymphocyte count abnormal 77.56 9.46 42 118181 2384 110468692
Neutropenic sepsis 69.60 9.46 121 118102 30625 110440451
Infective pulmonary exacerbation of cystic fibrosis 68.89 9.46 82 118141 14689 110456387
Drug intolerance 67.07 9.46 217 118006 406295 110064781
Therapeutic product effect decreased 64.33 9.46 101 118122 244215 110226861
Asthma 64.23 9.46 473 117750 249818 110221258
Synovitis 62.50 9.46 124 118099 273968 110197108
Myelosuppression 61.25 9.46 13 118210 94327 110376749
Pulmonary embolism 60.07 9.46 414 117809 214060 110257016
Drug interaction 59.84 9.46 303 117920 499880 109971196
Acute kidney injury 59.10 9.46 417 117806 635013 109836063
Off label use 58.19 9.46 1194 117029 1498991 108972085
Joint swelling 54.83 9.46 265 117958 442580 110028496
Nausea 54.59 9.46 1716 116507 1233974 109237102
Therapeutic product effect incomplete 52.98 9.46 99 118124 223706 110247370
Sputum increased 52.73 9.46 46 118177 5705 110465371
Constipation 51.93 9.46 598 117625 357188 110113888
Affective disorder 51.76 9.46 62 118161 11179 110459897
Salpingo-oophorectomy unilateral 49.50 9.46 22 118201 809 110470267
Lip swelling 49.06 9.46 142 118081 50525 110420551
Anaphylactic reaction 47.70 9.46 245 117978 114055 110357021
Chest pain 47.64 9.46 613 117610 375762 110095314
Anti-cyclic citrullinated peptide antibody positive 47.17 9.46 76 118147 181908 110289168
Drug therapy 47.06 9.46 48 118175 7243 110463833
Upper respiratory tract infection 47.04 9.46 270 117953 131058 110340018
Arthropathy 46.35 9.46 155 118068 287367 110183709
Hand deformity 46.32 9.46 103 118120 218403 110252673
Neuralgia 46.11 9.46 135 118088 48343 110422733
Analgesic therapy 45.29 9.46 47 118176 7237 110463839
Sinusitis fungal 45.28 9.46 31 118192 2689 110468387
Maternal exposure during pregnancy 44.89 9.46 132 118091 254751 110216325
Sleep disorder therapy 44.30 9.46 47 118176 7424 110463652
Swelling face 43.59 9.46 205 118018 92116 110378960
Back pain 42.71 9.46 594 117629 370402 110100674
Rheumatoid arthritis 42.71 9.46 170 118053 299443 110171633
Lactic acidosis 42.62 9.46 23 118200 92788 110378288
Chronic obstructive pulmonary disease 41.46 9.46 228 117995 108930 110362146
Cellulitis 41.22 9.46 253 117970 125763 110345313
Nasal congestion 40.54 9.46 210 118013 98072 110373004
Pericarditis 38.20 9.46 114 118109 219000 110252076
Hyperlipidaemia 38.17 9.46 104 118119 35744 110435332
Pemphigus 37.87 9.46 111 118112 214459 110256617
Anticoagulant therapy 37.74 9.46 37 118186 5324 110465752
Bronchospasm 37.62 9.46 93 118130 30146 110440930
Drug ineffective for unapproved indication 37.25 9.46 33 118190 102805 110368271
Antacid therapy 37.03 9.46 37 118186 5447 110465629
Anxiety 36.72 9.46 545 117678 344533 110126543
Hyperphosphataemia 36.47 9.46 64 118159 16317 110454759
Hepatic enzyme increased 36.31 9.46 198 118025 320694 110150382
Deep vein thrombosis 36.22 9.46 265 117958 139622 110331454
Completed suicide 36.16 9.46 135 118088 242246 110228830
Diarrhoea 35.48 9.46 1522 116701 1137983 109333093
Ejection fraction decreased 35.26 9.46 110 118113 40770 110430306
Excessive eye blinking 35.19 9.46 23 118200 1847 110469229
Glossodynia 34.87 9.46 121 118102 221883 110249193
Drug resistance 34.16 9.46 9 118214 56365 110414711
C-reactive protein increased 34.08 9.46 119 118104 217800 110253276
Hyperkalaemia 33.99 9.46 58 118165 135738 110335338
Nasal discomfort 33.35 9.46 37 118186 6144 110464932
Renal failure 32.63 9.46 128 118095 226446 110244630
Neutropenia 32.51 9.46 572 117651 374048 110097028
Sleep apnoea syndrome 32.31 9.46 106 118117 40341 110430735
Palpitations 32.18 9.46 285 117938 158927 110312149
Sinusitis 32.12 9.46 470 117753 296218 110174858
Pneumonia 31.89 9.46 1191 117032 875523 109595553
SARS-CoV-2 test positive 31.21 9.46 61 118162 16874 110454202
Lower respiratory tract infection 31.17 9.46 397 117826 242709 110228367
Systemic lupus erythematosus 30.98 9.46 153 118070 254185 110216891
Lacrimation increased 30.21 9.46 87 118136 30863 110440213
Neutropenic infection 29.84 9.46 26 118197 3219 110467857
Listless 29.64 9.46 30 118193 4485 110466591
Lethargy 29.43 9.46 186 118037 93390 110377686
Oxygen saturation decreased 29.18 9.46 276 117947 156706 110314370
Throat tightness 28.78 9.46 90 118133 33399 110437677
Pyrexia 28.40 9.46 1202 117021 897063 109574013
Sopor 28.37 9.46 3 118220 36543 110434533
Oropharyngeal pain 28.29 9.46 244 117979 135032 110336044
General physical health deterioration 27.99 9.46 305 117918 424990 110046086
Duodenal ulcer perforation 27.81 9.46 97 118126 177603 110293473
Mucosal inflammation 27.74 9.46 187 118036 95954 110375122
Emotional distress 27.67 9.46 108 118115 44739 110426337
Fatigue 27.58 9.46 1575 116648 1214383 109256693
Incorrect dose administered 26.63 9.46 196 118027 103445 110367631
Congenital hiatus hernia 26.35 9.46 33 118190 6226 110464850
Eosinophilic colitis 25.91 9.46 13 118210 630 110470446
Myasthenia gravis 25.54 9.46 65 118158 21446 110449630
Interstitial lung disease 25.37 9.46 71 118152 139263 110331813
Respiratory symptom 25.35 9.46 52 118171 14893 110456183
Hypoacusis 25.27 9.46 89 118134 35102 110435974
Blood pressure fluctuation 24.78 9.46 26 118197 74798 110396278
Helicobacter infection 24.77 9.46 105 118118 181772 110289304
Arthralgia 24.32 9.46 641 117582 778991 109692085
Gout 24.16 9.46 90 118133 36476 110434600
Stress 24.15 9.46 194 118029 105154 110365922
Rheumatoid factor positive 24.03 9.46 67 118156 131573 110339503
Hypophosphataemia 23.90 9.46 84 118139 33098 110437978
Plethoric face 23.86 9.46 6 118217 33 110471043
Therapy non-responder 23.86 9.46 87 118136 157220 110313856
Condition aggravated 23.76 9.46 601 117622 734235 109736841
Vulvovaginal candidiasis 23.74 9.46 23 118200 3262 110467814
Neuroleptic malignant syndrome 23.58 9.46 4 118219 34055 110437021
Urticaria 23.56 9.46 475 117748 318382 110152694
Febrile neutropenia 23.44 9.46 472 117751 316295 110154781
Urinary tract infection 23.10 9.46 483 117740 325799 110145277
Malignant neoplasm progression 23.03 9.46 102 118121 174465 110296611
Coma 23.02 9.46 58 118165 117811 110353265
Chest injury 23.02 9.46 23 118200 3386 110467690
Nail infection 23.01 9.46 20 118203 2468 110468608
Rhinorrhoea 22.96 9.46 188 118035 102478 110368598
Schizophrenia 22.92 9.46 63 118160 21763 110449313
Product use issue 22.77 9.46 218 118005 311477 110159599
Feeling hot 22.67 9.46 171 118052 90935 110380141
Hiatus hernia 22.63 9.46 73 118150 27533 110443543
Dilatation intrahepatic duct acquired 22.60 9.46 13 118210 830 110470246
Gallbladder polyp 22.21 9.46 15 118208 1272 110469804
Mood swings 22.14 9.46 64 118159 22748 110448328
Band sensation 22.11 9.46 14 118209 1064 110470012
Hypersomnia 21.93 9.46 73 118150 27988 110443088
Feeling cold 21.91 9.46 83 118140 33904 110437172
Erythema 21.81 9.46 435 117788 291012 110180064
Reduced facial expression 21.70 9.46 23 118200 3628 110467448
Myalgia 21.63 9.46 346 117877 222035 110249041
Headache 21.54 9.46 1151 117072 881226 109589850
Renal impairment 21.46 9.46 116 118107 188329 110282747
Tachycardia 21.44 9.46 351 117872 226294 110244782
Catheter site bruise 21.06 9.46 11 118212 580 110470496
Diastolic dysfunction 20.85 9.46 43 118180 12361 110458715
Toxicity to various agents 20.77 9.46 375 117848 480180 109990896
Infusion site erythema 20.74 9.46 42 118181 11917 110459159
Appendicitis 20.45 9.46 72 118151 28392 110442684
Coronary artery disease 20.41 9.46 139 118084 71551 110399525
Embolism venous 20.38 9.46 26 118197 4997 110466079
Necrotic lymphadenopathy 20.38 9.46 8 118215 214 110470862
Hypoxia 20.36 9.46 220 118003 129295 110341781
Blood calcium increased 19.87 9.46 53 118170 17987 110453089
Agranulocytosis 19.85 9.46 22 118201 61738 110409338
Foreign body 19.84 9.46 20 118203 2975 110468101
Bradycardia 19.84 9.46 92 118131 155425 110315651
Failure to anastomose 19.71 9.46 8 118215 234 110470842
Sinus tachycardia 19.70 9.46 97 118126 44396 110426680
Seizure 19.62 9.46 339 117884 220846 110250230
Toxic skin eruption 19.57 9.46 3 118220 27512 110443564
Painful respiration 19.48 9.46 22 118201 3725 110467351
Rhinitis allergic 19.08 9.46 52 118171 17870 110453206
Abdominal discomfort 19.08 9.46 301 117922 393557 110077519
Product dose omission issue 18.91 9.46 464 117759 321318 110149758
Bronchopulmonary aspergillosis allergic 18.86 9.46 33 118190 8393 110462683
Transient ischaemic attack 18.78 9.46 125 118098 63857 110407219
Cholestasis 18.61 9.46 25 118198 64493 110406583
Eosinophilia 18.23 9.46 21 118202 57915 110413161
C-reactive protein abnormal 18.20 9.46 74 118149 129621 110341455
Oedema peripheral 18.16 9.46 470 117753 328190 110142886
Acute sinusitis 18.11 9.46 25 118198 5186 110465890
Hyperhidrosis 18.06 9.46 291 117932 187007 110284069
Rhabdomyolysis 17.99 9.46 67 118156 120334 110350742
Confusional arousal 17.98 9.46 7 118216 183 110470893
Blood pressure diastolic abnormal 17.94 9.46 3 118220 25812 110445264
Wound 17.53 9.46 163 118060 234274 110236802
Gastroenteritis viral 17.51 9.46 73 118150 31153 110439923
Haemorrhoids 17.42 9.46 80 118143 35592 110435484
Nasal turbinate hypertrophy 17.41 9.46 11 118212 833 110470243
Red blood cell sedimentation rate increased 17.34 9.46 36 118187 78266 110392810
Activated partial thromboplastin time prolonged 17.31 9.46 58 118165 22310 110448766
Bicuspid aortic valve 17.27 9.46 5 118218 50 110471026
Chemical burns of eye 17.20 9.46 6 118217 114 110470962
Hysterectomy 17.16 9.46 31 118192 8083 110462993
Rhinitis 17.04 9.46 58 118165 22487 110448589
Blood phosphorus increased 16.99 9.46 47 118176 16293 110454783
Cardiac failure 16.97 9.46 124 118099 187502 110283574
Poor quality device used 16.95 9.46 18 118205 2845 110468231
Pancytopenia 16.88 9.46 143 118080 209470 110261606
Sinus headache 16.70 9.46 26 118197 6006 110465070
Bronchitis 16.68 9.46 248 117975 156784 110314292
Diverticulum 16.48 9.46 45 118178 15481 110455595
Hot flush 16.46 9.46 124 118099 65912 110405164
Pleuritic pain 16.37 9.46 46 118177 16094 110454982
Dizziness 16.27 9.46 907 117316 697286 109773790
Polyglandular disorder 16.23 9.46 7 118216 239 110470837
COVID-19 16.13 9.46 359 117864 244701 110226375
Blood pressure systolic increased 16.08 9.46 41 118182 82950 110388126
Inflammation 15.93 9.46 131 118092 193107 110277969
Bronchopulmonary aspergillosis 15.90 9.46 6 118217 29857 110441219
Wheezing 15.89 9.46 371 117852 254859 110216217
Acute respiratory failure 15.86 9.46 136 118087 75124 110395952
Therapy partial responder 15.86 9.46 10 118213 37051 110434025
Appendicolith 15.82 9.46 42 118181 14213 110456863
Vertigo 15.77 9.46 152 118071 86718 110384358
Discomfort 15.75 9.46 150 118073 214557 110256519
Haemophagocytic lymphohistiocytosis 15.73 9.46 7 118216 31552 110439524
Product prescribing error 15.73 9.46 19 118204 51312 110419764
Hip arthroplasty 15.72 9.46 22 118201 55791 110415285
Tubulointerstitial nephritis 15.69 9.46 21 118202 54263 110416813
Troponin increased 15.47 9.46 68 118155 29698 110441378
Biliary sepsis 15.42 9.46 14 118209 1829 110469247
Shock haemorrhagic 15.32 9.46 5 118218 27242 110443834
Apathy 15.23 9.46 45 118178 16194 110454882
Dyspnoea exertional 15.10 9.46 174 118049 103886 110367190
Impaired healing 15.04 9.46 136 118087 196581 110274495
Sinus disorder 14.95 9.46 72 118151 32656 110438420
Premature delivery 14.95 9.46 7 118216 30625 110440451
Tonsillar hypertrophy 14.82 9.46 14 118209 1924 110469152
Psoriatic arthropathy 14.63 9.46 137 118086 196624 110274452
Polyneuropathy 14.60 9.46 8 118215 32004 110439072
Head discomfort 14.47 9.46 49 118174 18951 110452125
Chills 14.43 9.46 285 117938 190295 110280781
Retching 14.30 9.46 55 118168 22627 110448449
Vision blurred 14.18 9.46 205 118018 128817 110342259
Epilepsy 14.17 9.46 57 118166 100152 110370924
Rash macular 14.15 9.46 80 118143 38606 110432470
Iron deficiency anaemia 14.11 9.46 69 118154 31490 110439586
Cystic fibrosis 13.96 9.46 21 118202 4710 110466366
Biliary dyskinesia 13.95 9.46 15 118208 2406 110468670
Suffocation feeling 13.92 9.46 14 118209 2077 110468999
Nephropathy toxic 13.85 9.46 6 118217 27472 110443604
Pulmonary fibrosis 13.84 9.46 59 118164 101983 110369093
Mobility decreased 13.77 9.46 175 118048 237247 110233829
Cholecystitis chronic 13.75 9.46 31 118192 9469 110461607
Bronchial neoplasm 13.66 9.46 8 118215 528 110470548
HIV associated nephropathy 13.65 9.46 7 118216 355 110470721
Blister infected 13.57 9.46 11 118212 1233 110469843
Intentional self-injury 13.56 9.46 12 118211 37417 110433659
Dyspnoea paroxysmal nocturnal 13.54 9.46 15 118208 2487 110468589
Pancreatitis chronic 13.43 9.46 20 118203 4445 110466631
Seasonal allergy 13.41 9.46 49 118174 19673 110451403
Intentional product misuse 13.38 9.46 208 118015 132696 110338380
Periorbital oedema 13.37 9.46 32 118191 10160 110460916
Bone pain 13.36 9.46 117 118106 65016 110406060
Vascular compression 13.23 9.46 9 118214 772 110470304
Altered state of consciousness 13.18 9.46 26 118197 57600 110413476
Musculoskeletal stiffness 13.16 9.46 215 118008 279607 110191469
Micturition urgency 13.14 9.46 48 118175 19272 110451804
Candida infection 13.03 9.46 92 118131 47917 110423159
Inappropriate schedule of product administration 12.99 9.46 147 118076 203490 110267586
Transplant rejection 12.97 9.46 5 118218 24562 110446514
Bacterial infection 12.95 9.46 89 118134 45947 110425129
Multi-organ disorder 12.94 9.46 17 118206 3364 110467712
Poor peripheral circulation 12.91 9.46 19 118204 4178 110466898
Neutrophil count increased 12.90 9.46 72 118151 34580 110436496
Presyncope 12.87 9.46 93 118130 48794 110422282
Pelvic infection 12.77 9.46 7 118216 407 110470669
Muscle injury 12.76 9.46 93 118130 140714 110330362
Hallucination, auditory 12.74 9.46 59 118164 26338 110444738
Loss of personal independence in daily activities 12.69 9.46 101 118122 149919 110321157
Blood uric acid increased 12.60 9.46 51 118172 21478 110449598
Tremor 12.60 9.46 294 117929 201938 110269138
Gastrooesophageal reflux disease 12.59 9.46 266 117957 179710 110291366
Umbilical hernia 12.59 9.46 25 118198 6997 110464079
Blood pressure diastolic decreased 12.42 9.46 12 118211 35873 110435203
Drug tolerance decreased 12.39 9.46 7 118216 27533 110443543
Liver injury 12.38 9.46 102 118121 150311 110320765
Delusion of replacement 12.37 9.46 6 118217 270 110470806
Therapeutic response decreased 12.36 9.46 57 118166 96442 110374634
Oral candidiasis 12.28 9.46 86 118137 44674 110426402
Creatinine renal clearance decreased 12.27 9.46 4 118219 21811 110449265
Ureteric haemorrhage 12.26 9.46 5 118218 148 110470928
Tympanic membrane hyperaemia 12.17 9.46 3 118220 15 110471061
Peripheral pulse decreased 12.16 9.46 4 118219 63 110471013
Benign prostatic hyperplasia 12.14 9.46 45 118178 18189 110452887
Rheumatic fever 12.07 9.46 79 118144 122500 110348576
Failure of child resistant product closure 11.93 9.46 4 118219 67 110471009
Vomiting 11.90 9.46 1129 117094 909546 109561530
Cyanosis 11.88 9.46 63 118160 29678 110441398
Hypervolaemia 11.84 9.46 92 118131 49368 110421708
Nasal polyps 11.83 9.46 36 118187 13164 110457912
Adverse event 11.83 9.46 68 118155 108741 110362335
Intentional product use issue 11.82 9.46 190 118033 247716 110223360
Grip strength decreased 11.72 9.46 45 118178 80129 110390947
Emphysema 11.72 9.46 47 118176 19709 110451367
Vestibular neuronitis 11.63 9.46 9 118214 944 110470132
Nail dystrophy 11.62 9.46 10 118213 1218 110469858
Retinal detachment 11.61 9.46 32 118191 11068 110460008
Pain in jaw 11.59 9.46 94 118129 51083 110419993
Otitis media 11.50 9.46 25 118198 7451 110463625
Drug reaction with eosinophilia and systemic symptoms 11.42 9.46 47 118176 82048 110389028
Laryngospasm 11.39 9.46 19 118204 4649 110466427
Hyperpyrexia 11.31 9.46 26 118197 8043 110463033
Abnormal behaviour 11.30 9.46 76 118147 38963 110432113
Death 11.18 9.46 622 117601 698247 109772829
Knee arthroplasty 11.16 9.46 34 118189 64914 110406162
Nasal herpes 11.08 9.46 8 118215 755 110470321
Iron deficiency 11.00 9.46 44 118179 18432 110452644
Posterior reversible encephalopathy syndrome 10.95 9.46 12 118211 33849 110437227
Diverticulitis 10.90 9.46 96 118127 53426 110417650
Pulmonary alveolar haemorrhage 10.81 9.46 4 118219 20146 110450930
Haemodialysis complication 10.73 9.46 6 118217 363 110470713
Folliculitis 10.71 9.46 121 118102 167532 110303544
Intentional product misuse to child 10.70 9.46 5 118218 207 110470869
Essential hypertension 10.69 9.46 25 118198 7822 110463254
Swollen tongue 10.66 9.46 105 118118 60257 110410819
Accidental exposure to product by child 10.60 9.46 15 118208 3183 110467893
Prosopagnosia 10.60 9.46 4 118219 96 110470980
Prescribed underdose 10.58 9.46 35 118188 65139 110405937
Bronchial haemorrhage 10.57 9.46 10 118213 1377 110469699
Bone erosion 10.54 9.46 21 118202 46350 110424726
Infusion site mass 10.47 9.46 11 118212 1717 110469359
Infusion site pruritus 10.42 9.46 19 118204 4989 110466087
Irritability 10.39 9.46 87 118136 47722 110423354
Cystic fibrosis related diabetes 10.37 9.46 5 118218 222 110470854
Sepsis 10.29 9.46 438 117785 326908 110144168
Blister 10.27 9.46 176 118047 227200 110243876
Exposure during pregnancy 10.24 9.46 122 118101 167302 110303774
Gait disturbance 10.22 9.46 223 118000 277985 110193091
Product quality issue 10.22 9.46 127 118096 77172 110393904
Therapy interrupted 10.13 9.46 24 118199 49798 110421278
Optic disc drusen 10.11 9.46 3 118220 33 110471043
International normalised ratio increased 10.10 9.46 53 118170 86719 110384357
Victim of chemical submission 10.07 9.46 8 118215 871 110470205
Panic attack 10.03 9.46 59 118164 28881 110442195
Faeces hard 9.99 9.46 17 118206 4229 110466847
Abnormal sensation in eye 9.97 9.46 12 118211 2174 110468902
Septic shock 9.94 9.46 114 118109 157414 110313662
Infusion site swelling 9.87 9.46 28 118195 9849 110461227
Aplastic anaemia 9.81 9.46 7 118216 24301 110446775
Thrombotic microangiopathy 9.80 9.46 10 118213 29139 110441937
Reading disorder 9.78 9.46 9 118214 1196 110469880
Ventricular extrasystoles 9.77 9.46 49 118174 22592 110448484
Oropharyngeal blistering 9.73 9.46 8 118215 915 110470161
Pulmonary hypertension 9.72 9.46 96 118127 55124 110415952
Obstructive defaecation 9.69 9.46 5 118218 257 110470819
Deafness permanent 9.67 9.46 8 118215 923 110470153
Joint stiffness 9.67 9.46 38 118185 67205 110403871
Acute hepatic failure 9.66 9.46 15 118208 36453 110434623
Posterior tibial nerve injury 9.65 9.46 3 118220 39 110471037
Hiccups 9.63 9.46 33 118190 12836 110458240
Endometrial ablation 9.54 9.46 8 118215 940 110470136
Irritable bowel syndrome 9.54 9.46 121 118102 164094 110306982

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
ATC R06AB04 RESPIRATORY SYSTEM
ANTIHISTAMINES FOR SYSTEMIC USE
ANTIHISTAMINES FOR SYSTEMIC USE
Substituted alkylamines
ATC R06AB54 RESPIRATORY SYSTEM
ANTIHISTAMINES FOR SYSTEMIC USE
ANTIHISTAMINES FOR SYSTEMIC USE
Substituted alkylamines
FDA MoA N0000000190 Histamine H1 Receptor Antagonists
CHEBI has role CHEBI:35480 analgesic
CHEBI has role CHEBI:51177 antitussive
CHEBI has role CHEBI:77715 nasal decongestant
MeSH PA D000982 Antipruritics
MeSH PA D003879 Dermatologic Agents
MeSH PA D006633 Histamine Antagonists
MeSH PA D006634 Histamine H1 Antagonists
MeSH PA D018377 Neurotransmitter Agents
MeSH PA D018926 Anti-Allergic Agents
FDA EPC N0000175587 Histamine-1 Receptor Antagonist
CHEBI has role CHEBI:35469 antidepressant
CHEBI has role CHEBI:37955 H<small><sub>1</sub></small>-receptor antagonist
CHEBI has role CHEBI:37956 histamine antagonist
CHEBI has role CHEBI:50857 anti-allergic agent
CHEBI has role CHEBI:50949 serotonin uptake inhibitor
CHEBI has role CHEBI:59683 antipruritic drug
CHEBI has role CHEBI:22587 antiviral agent
CHEBI has role CHEBI:64951 anti-HBV agent

Related Drugs by ATC class:

R06AB Substituted alkylamines 6 drugs
brompheniraminedexbrompheniraminedexchlorpheniraminedimetindenepheniraminetalastine

Drug Use | Suggest Off label Use Form| |View source of the data|

DiseaseRelationSNOMED_IDDOID
Dermatographic urticaria indication 7632005 DOID:743
Vasomotor rhinitis indication 8229003 DOID:4730
Allergic rhinitis indication 61582004
Nasal discharge indication 64531003
Nasal congestion indication 68235000
Sneezing indication 76067001
Common cold indication 82272006 DOID:10459
Urticaria indication 126485001
Influenza-like symptoms indication 315642008
Seasonal allergic rhinitis indication 367498001
Itching of skin indication 418363000
Allergic conjunctivitis indication 473460002 DOID:11204
Brain damage contraindication 2470005
Necrotizing enterocolitis in fetus OR newborn contraindication 2707005
Goiter contraindication 3716002 DOID:12176
Ocular hypertension contraindication 4210003 DOID:9282
Gastritis contraindication 4556007 DOID:4029
Tachyarrhythmia contraindication 6285003
Suicidal thoughts contraindication 6471006
Dependent drug abuse contraindication 6525002
Urinary tract obstruction contraindication 7163005 DOID:5200
Alcoholism contraindication 7200002
Alcohol withdrawal delirium contraindication 8635005
Peptic ulcer contraindication 13200003 DOID:750
Chronic obstructive lung disease contraindication 13645005 DOID:3083
Asthenia contraindication 13791008
Hyperkalemia contraindication 14140009
Severe chronic ulcerative colitis contraindication 14311001
Constipation contraindication 14760008 DOID:2089
Disorder of autonomic nervous system contraindication 15241006
Chronic disease of respiratory system contraindication 17097001
Mood swings contraindication 18963009
Hashimoto thyroiditis contraindication 21983002
Myocardial infarction contraindication 22298006 DOID:5844
Glaucoma contraindication 23986001 DOID:1686
Inflammatory bowel disease contraindication 24526004 DOID:0050589
Ventricular tachycardia contraindication 25569003
Acute tuberculosis contraindication 25629007
Alcohol intoxication contraindication 25702006
Shock contraindication 27942005
Toxic megacolon contraindication 28536002 DOID:1770
Atony of colon contraindication 29479008
Hypercapnia contraindication 29596007
Bronchitis contraindication 32398004 DOID:6132
Dehydration contraindication 34095006
Hyperthyroidism contraindication 34486009 DOID:7998
Acute hepatitis contraindication 37871000
Hypertensive disorder contraindication 38341003 DOID:10763
Hypovolemic shock contraindication 39419009
Disorder of gallbladder contraindication 39621005 DOID:0060262
Gastrointestinal ulcer contraindication 40845000
Hypothyroidism contraindication 40930008 DOID:1459
Complete trisomy 21 syndrome contraindication 41040004 DOID:14250
Body fluid retention contraindication 43498006
Conduction disorder of the heart contraindication 44808001
Low blood pressure contraindication 45007003
Achalasia of esophagus contraindication 45564002 DOID:9164
Chronic heart failure contraindication 48447003
Bradycardia contraindication 48867003
Disorder of cardiovascular system contraindication 49601007 DOID:1287
Acidosis contraindication 51387008
Gastrointestinal perforation contraindication 51875005
Vitamin K deficiency contraindication 52675005 DOID:11249
Nasal polyp contraindication 52756005
Coronary arteriosclerosis contraindication 53741008 DOID:3393
Paralytic ileus contraindication 55525008 DOID:8442
Peptic reflux disease contraindication 57643001
Acute nephropathy contraindication 58574008
Hepatic failure contraindication 59927004
Ulcerative colitis contraindication 64766004 DOID:8577
Blood coagulation disorder contraindication 64779008 DOID:1247
Arterial thrombosis contraindication 65198009
Drug AND/OR toxin-induced diarrhea contraindication 65979008
Substance abuse contraindication 66214007
Benign intracranial hypertension contraindication 68267002 DOID:11459
Psychotic disorder contraindication 69322001
Poisoning by acetaminophen contraindication 70273001
Agoraphobia contraindication 70691001 DOID:593
Arteriosclerotic vascular disease contraindication 72092001
Diabetes mellitus contraindication 73211009 DOID:9351
Factor II deficiency contraindication 73975000
Reye's syndrome contraindication 74351001 DOID:14525
Gastrointestinal hemorrhage contraindication 74474003
Urethral stricture contraindication 76618002
Thrombotic thrombocytopenic purpura contraindication 78129009 DOID:10772
Spastic paralysis contraindication 78403003
Disturbance of salivary secretion contraindication 78948009
Decreased respiratory function contraindication 80954004
Injury of head contraindication 82271004
Chronic idiopathic constipation contraindication 82934008
Cor pulmonale contraindication 83291003 DOID:8515
Hiatal hernia contraindication 84089009 DOID:12642
Epilepsy contraindication 84757009 DOID:1826
Pulmonary emphysema contraindication 87433001
Gout contraindication 90560007 DOID:13189
Kidney disease contraindication 90708001 DOID:557
Thyrotoxicosis contraindication 90739004 DOID:7997
Hemophilia contraindication 90935002
Myasthenia gravis contraindication 91637004 DOID:437
Dermatitis herpetiformis contraindication 111196000 DOID:8505
Anemia due to enzyme deficiency contraindication 111577008
Acute abdominal pain contraindication 116290004
Procedure on urinary system contraindication 118677009
Gastrointestinal obstruction contraindication 126765001
Neoplasm of brain contraindication 126952004 DOID:1319
von Willebrand disorder contraindication 128105004 DOID:12531
Seizure disorder contraindication 128613002
Autonomic dysreflexia contraindication 129618003
Bleeding contraindication 131148009
Drug-induced psychosis contraindication 191483003 DOID:1742
Obsessive-compulsive disorder contraindication 191736004 DOID:10933
Insomnia contraindication 193462001
Partial atrioventricular block contraindication 195039008
Acute pancreatitis contraindication 197456007 DOID:2913
Impaired renal function disorder contraindication 197663003
Coronary artery bypass graft contraindication 232717009
Myocardial dysfunction contraindication 233928007
Gastroesophageal reflux disease contraindication 235595009 DOID:8534
Disease of liver contraindication 235856003 DOID:409
Bladder outflow obstruction contraindication 236645006
Morbid obesity contraindication 238136002 DOID:11981
Hypocomplementemic urticarial vasculitis contraindication 239945009
Pyloric obstruction contraindication 244815007
Benign prostatic hyperplasia contraindication 266569009
Retention of urine contraindication 267064002
Anemia contraindication 271737000 DOID:2355
Drowsy contraindication 271782001
Exacerbation of asthma contraindication 281239006
Pregnancy, function contraindication 289908002
Lesion of brain contraindication 301766008
Thrombocytopenic disorder contraindication 302215000 DOID:1588
Panic disorder contraindication 371631005 DOID:594
Coma contraindication 371632003
Primary adrenocortical insufficiency contraindication 373662000
Operation on gastrointestinal tract contraindication 386621005
Hypoxia contraindication 389086002
Angle-closure glaucoma contraindication 392291006 DOID:13550
Cardiovascular event risk contraindication 395112001
Pseudomembranous enterocolitis contraindication 397683000
Gastric ulcer contraindication 397825006 DOID:10808
Breastfeeding (mother) contraindication 413712001
Chronic lung disease contraindication 413839001
Chronic myocardial ischemia contraindication 413844008 DOID:3393
Disorder of coronary artery contraindication 414024009
Myocardial ischemia contraindication 414795007 DOID:3393
Myocardial infarction in recovery phase contraindication 418044006
Central nervous system depression contraindication 418072004
Ultrarapid metabolizer due to cytochrome p450 CYP2D6 variant contraindication 422681000
Fever greater than 100.4 Fahrenheit contraindication 426000000
Dysfunction of sphincter of Oddi contraindication 430887001
Hypertensive urgency contraindication 443482000
Acute erosive gastritis contraindication 444926003
Smokes tobacco daily contraindication 449868002
Acute exacerbation of asthma contraindication 708038006
Acute Thromboembolic Stroke contraindication




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 9.47 Basic
pKa2 4.14 Basic

Orange Book patent data (new drug applications)

Formulation strengthTrade nameApplicantApplication numberApproval dateTypeDose formRoutePatent numberPatent expiration datePatent use
8MG;54.3MG TUXARIN ER MAINPOINTE N206323 June 22, 2015 RX TABLET, EXTENDED RELEASE ORAL 9066942 Jan. 3, 2032 TREATMENT OF COUGH AND SYMPTOMS ASSOCIATED WITH UPPER RESPIRATORY ALLERGIES OR A COMMON COLD WITH CODEINE PHOSPHATE AND CHLORPHENIRAMINE MALEATE ORALLY ADMINISTERED EXTENDED RELEASE TABLETS

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])		Mechanism
action		Bioact sourceMoA source
Histamine H1 receptor GPCR ANTAGONIST Ki 8.15 WOMBAT-PK CHEMBL
Sodium-dependent serotonin transporter Transporter Kd 7.82 WOMBAT-PK
5-hydroxytryptamine receptor 2B GPCR Ki 5.17 PDSP
Histamine H4 receptor GPCR Ki 6.67 WOMBAT-PK
Cytochrome P450 2D6 Enzyme Ki 4.97 WOMBAT-PK
Sodium channel alpha subunits; brain (Types I, II, III) Ion channel IC50 5 CHEMBL
Lethal(3)malignant brain tumor-like protein 1 Nuclear other IC50 4.39 CHEMBL
Lethal(3)malignant brain tumor-like protein 3 Nuclear other IC50 4.38 CHEMBL
MBT domain-containing protein 1 Nuclear other IC50 4.47 CHEMBL
Sodium-dependent noradrenaline transporter Transporter Kd 5.84 SCIENTIFIC LITERATURE
Potassium voltage-gated channel subfamily H member 2 Ion channel IC50 5.96 CHEMBL
Sodium-dependent dopamine transporter Transporter Kd 5.98 SCIENTIFIC LITERATURE
Histamine H1 receptor GPCR IC50 8.06 CHEMBL
Histamine H1 receptor GPCR Ki 8.70 CHEMBL
Chloroquine resistance transporter Transporter IC50 4.27 CHEMBL

External reference:

IDSource
4017865 VUID
N0000146218 NUI
D00665 KEGG_DRUG
113-92-8 SECONDARY_CAS_RN
1405-56-7 SECONDARY_CAS_RN
142429 RXNORM
C0008281 UMLSCUI
CHEBI:52010 CHEBI
CHEMBL505 ChEMBL_ID
CHEMBL1659 ChEMBL_ID
DB01114 DRUGBANK_ID
2725 PUBCHEM_CID
32347 MMSL
32562 MMSL
3966 MMSL
4425 MMSL
4426 MMSL
4427 MMSL
4751 MMSL
93262 MMSL
d00191 MMSL
003391 NDDF
003392 NDDF
004430 NDDF
004431 NDDF
372914003 SNOMEDCT_US
438256006 SNOMEDCT_US
85737002 SNOMEDCT_US
9944001 SNOMEDCT_US
D002744 MESH_DESCRIPTOR_UI
CHEMBL1201659 ChEMBL_ID
6976 IUPHAR_LIGAND_ID
104 INN_ID
4017864 VANDF
4017865 VANDF
4018446 VANDF
4019408 VANDF
3U6IO1965U UNII
3U6IO1965U INXIGHT DRUGS

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
Childrens Robitussin Nighttime Cough Long-Acting DM HUMAN OTC DRUG LABEL 2 0031-8692 SOLUTION 2 mg ORAL OTC Monograph Drug 17 sections
CHILDRENS ROBITUSSIN COUGH AND COLD LONG-ACTING HUMAN OTC DRUG LABEL 2 0031-8693 LIQUID 2 mg ORAL OTC Monograph Drug 17 sections
Theraflu-D Flu Relief Max Strength plus Nasal Decongestant Nighttime HUMAN OTC DRUG LABEL 4 0067-0114 SYRUP 4 mg ORAL OTC Monograph Drug 17 sections
Theraflu Flu Relief Max Strength Nighttime HUMAN OTC DRUG LABEL 3 0067-7922 POWDER 4 mg ORAL OTC Monograph Drug 16 sections
Theraflu Flu Relief Max Strength Nighttime HUMAN OTC DRUG LABEL 3 0067-8205 SYRUP 4 mg ORAL OTC Monograph Drug 17 sections
FLONASE Headache and Allergy Relief HUMAN OTC DRUG LABEL 3 0135-0578 TABLET 2 mg ORAL OTC Monograph Drug 17 sections
Panadol Cold and Flu Night HUMAN OTC DRUG LABEL 3 0135-7034 TABLET 2 mg ORAL OTC Monograph Drug 16 sections
Alka-Seltzer Plus Severe Cold PowerFast FizzOrange Zest HUMAN OTC DRUG LABEL 3 0280-0020 TABLET, EFFERVESCENT 2 mg ORAL OTC Monograph Drug 17 sections
Alka-Seltzer Plus Severe Cold and Cough PowerFast Fizz HUMAN OTC DRUG LABEL 4 0280-0023 TABLET, EFFERVESCENT 2 mg ORAL OTC Monograph Drug 16 sections
ANTIFLU HUMAN OTC DRUG LABEL 3 0280-0044 TABLET, COATED 2 mg ORAL Export only 2 sections
Antiflupowder HUMAN OTC DRUG LABEL 3 0280-0045 POWDER, FOR SOLUTION 4 mg ORAL Export only 1 sections
Antiflu Kids HUMAN OTC DRUG LABEL 3 0280-0046 POWDER, FOR SOLUTION 1 mg ORAL Export only 2 sections
Alka-Seltzer Plus Maximum Strength Sinus Congestion and Pain PowerFast Fizz HUMAN OTC DRUG LABEL 4 0280-0055 TABLET, EFFERVESCENT 2 mg ORAL OTC Monograph Drug 15 sections
Alka-Seltzer Plus Cold Sparkling Original PowerFast Fizz HUMAN OTC DRUG LABEL 3 0280-0060 TABLET, EFFERVESCENT 2 mg ORAL OTC Monograph Drug 15 sections
Alka-Seltzer Plus Severe Cold and Flu PowerFast Fizz HUMAN OTC DRUG LABEL 4 0280-0088 TABLET, EFFERVESCENT 2 mg ORAL OTC Monograph Drug 15 sections
Alka-Seltzer Plus Maximum Strength Cold and Cough Power Max Gels HUMAN OTC DRUG LABEL 4 0280-0092 CAPSULE, LIQUID FILLED 2 mg ORAL OTC Monograph Drug 16 sections
Alka-Seltzer Plus Severe Cold Night PowerFast Fizz HUMAN OTC DRUG LABEL 4 0280-0121 TABLET, EFFERVESCENT 2 mg ORAL OTC Monograph Drug 16 sections
Alka-Seltzer Plus Cold and Flu FizzyChews HUMAN OTC DRUG LABEL 3 0280-0151 TABLET, CHEWABLE 2 mg ORAL OTC Monograph Drug 16 sections
Alka-Seltzer Plus Cold Medicine Sparkling Original HUMAN OTC DRUG LABEL 3 0280-1400 TABLET, EFFERVESCENT 2 mg ORAL OTC Monograph Drug 17 sections
Alka-Seltzer Plus Cold Orange Zest HUMAN OTC DRUG LABEL 3 0280-1510 TABLET, EFFERVESCENT 2 mg ORAL OTC Monograph Drug 17 sections
Alka-Seltzer Plus Cold Sparkling Original HUMAN OTC DRUG LABEL 3 0280-1520 TABLET, EFFERVESCENT 2 mg ORAL OTC Monograph Drug 17 sections
Alka-Seltzer Plus Cold and Cough HUMAN OTC DRUG LABEL 4 0280-1555 TABLET, EFFERVESCENT 2 mg ORAL OTC Monograph Drug 16 sections
Alka-Seltzer Plus Severe Cold and Flu HUMAN OTC DRUG LABEL 4 0280-1560 TABLET, EFFERVESCENT 2 mg ORAL OTC monograph final 17 sections
Alka-Seltzer Plus Maximum Strength Cold and Cough Liquid Gels HUMAN OTC DRUG LABEL 4 0280-1570 CAPSULE, LIQUID FILLED 2 mg ORAL OTC Monograph Drug 16 sections
Alka Seltzer Cold Cold and Congestion Severe Night Fast Dissolve HUMAN OTC DRUG LABEL 4 0280-8265 TABLET, EFFERVESCENT 2 mg ORAL OTC Monograph Drug 16 sections
ALKA SELTZER COLD Cold and Headache Maximum Strength Fast DissolveOrange HUMAN OTC DRUG LABEL 3 0280-8266 TABLET, EFFERVESCENT 2 mg ORAL OTC Monograph Drug 17 sections
ALKA SELTZER COLD Cold and Cough Maximum Strength Fast Dissolve HUMAN OTC DRUG LABEL 4 0280-8267 TABLET, EFFERVESCENT 2 mg ORAL OTC Monograph Drug 16 sections
ALKA SELTZER COLD Cold Flu and Congestion Severe Fast Dissolve HUMAN OTC DRUG LABEL 4 0280-8268 TABLET, EFFERVESCENT 2 mg ORAL OTC Monograph Drug 15 sections
ALKA SELTZER COLD Cold and Flu Severe Fast Chewables HUMAN OTC DRUG LABEL 3 0280-8269 TABLET, CHEWABLE 2 mg ORAL OTC Monograph Drug 15 sections
ALKA SELTZER COLD Cold and Headache Maximum Strength Fast Dissolve HUMAN OTC DRUG LABEL 3 0280-8270 TABLET, EFFERVESCENT 2 mg ORAL OTC Monograph Drug 14 sections