brompheniramine 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |
| Stem definition | Drug id | CAS RN |
|---|---|---|
| 408 | 86-22-6 |
Description:
| Molecule | Description |
|---|---|
|
Synonyms:
|
Histamine H1 antagonist used in treatment of allergies, rhinitis, and urticaria.
Legend: OFP - off patent OFM - off market ONP - on patent |
Drug dosage:
| Dose | Unit | Route |
|---|---|---|
| 24 | mg | O |
ADMET properties:
| Property | Value | Reference |
|---|---|---|
| BA (Bioavailability) | 89 % | Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H |
| S (Water solubility) | 46 mg/mL | Bocci G, Oprea TI, Benet LZ |
| BDDCS (Biopharmaceutical Drug Disposition Classification System) | 1 | Bocci G, Oprea TI, Benet LZ |
Approvals:
| Date | Agency | Company | Orphan |
|---|---|---|---|
| Aug. 23, 1957 | FDA |
FDA Adverse Event Reporting System (Female)
None
FDA Adverse Event Reporting System (Male)
None
FDA Adverse Event Reporting System (Geriatric)
None
FDA Adverse Event Reporting System (Pediatric)
None
Pharmacologic Action:
| Source | Code | Description |
|---|---|---|
| ATC | R06AB01 | RESPIRATORY SYSTEM ANTIHISTAMINES FOR SYSTEMIC USE ANTIHISTAMINES FOR SYSTEMIC USE Substituted alkylamines |
| ATC | R06AB51 | RESPIRATORY SYSTEM ANTIHISTAMINES FOR SYSTEMIC USE ANTIHISTAMINES FOR SYSTEMIC USE Substituted alkylamines |
| CHEBI has role | CHEBI:37955 | H1 receptor antagonists |
| CHEBI has role | CHEBI:50857 | anti-allergic drugs |
| MeSH PA | D018926 | Anti-Allergic Agents |
| MeSH PA | D018494 | Histamine Agents |
| MeSH PA | D006633 | Histamine Antagonists |
| MeSH PA | D006634 | Histamine H1 Antagonists |
| MeSH PA | D018377 | Neurotransmitter Agents |
Drug Use | Suggest Off label Use Form| |View source of the data|
| Disease | Relation | SNOMED_ID | DOID |
|---|---|---|---|
| Dermatographic urticaria | indication | 7632005 | DOID:743 |
| Vasomotor rhinitis | indication | 8229003 | DOID:4730 |
| Allergic rhinitis | indication | 61582004 | |
| Nasal discharge | indication | 64531003 | |
| Urticaria | indication | 126485001 | |
| Influenza-like symptoms | indication | 315642008 | |
| Seasonal allergic rhinitis | indication | 367498001 | |
| Itching of skin | indication | 418363000 | |
| Allergic conjunctivitis | indication | 473460002 | DOID:11204 |
| Brain damage | contraindication | 2470005 | |
| Ocular hypertension | contraindication | 4210003 | DOID:9282 |
| Tachyarrhythmia | contraindication | 6285003 | |
| Suicidal thoughts | contraindication | 6471006 | |
| Dependent drug abuse | contraindication | 6525002 | |
| Urinary tract obstruction | contraindication | 7163005 | DOID:5200 |
| Alcoholism | contraindication | 7200002 | |
| Alcohol withdrawal delirium | contraindication | 8635005 | |
| Peptic ulcer | contraindication | 13200003 | DOID:750 |
| Chronic obstructive lung disease | contraindication | 13645005 | DOID:3083 |
| Asthenia | contraindication | 13791008 | |
| Severe chronic ulcerative colitis | contraindication | 14311001 | |
| Constipation | contraindication | 14760008 | DOID:2089 |
| Chronic disease of respiratory system | contraindication | 17097001 | |
| Mood swings | contraindication | 18963009 | |
| Myocardial infarction | contraindication | 22298006 | DOID:5844 |
| Inflammatory bowel disease | contraindication | 24526004 | DOID:0050589 |
| Ventricular tachycardia | contraindication | 25569003 | |
| Alcohol intoxication | contraindication | 25702006 | |
| Shock | contraindication | 27942005 | |
| Toxic megacolon | contraindication | 28536002 | DOID:1770 |
| Atony of colon | contraindication | 29479008 | |
| Hypercapnia | contraindication | 29596007 | |
| Dehydration | contraindication | 34095006 | |
| Hyperthyroidism | contraindication | 34486009 | DOID:7998 |
| Acute hepatitis | contraindication | 37871000 | |
| Hypertensive disorder | contraindication | 38341003 | DOID:10763 |
| Disorder of gallbladder | contraindication | 39621005 | DOID:0060262 |
| Hypothyroidism | contraindication | 40930008 | DOID:1459 |
| Complete trisomy 21 syndrome | contraindication | 41040004 | DOID:14250 |
| Conduction disorder of the heart | contraindication | 44808001 | |
| Low blood pressure | contraindication | 45007003 | |
| Achalasia of esophagus | contraindication | 45564002 | DOID:9164 |
| Chronic heart failure | contraindication | 48447003 | |
| Bradycardia | contraindication | 48867003 | |
| Disorder of cardiovascular system | contraindication | 49601007 | DOID:1287 |
| Acidosis | contraindication | 51387008 | |
| Coronary arteriosclerosis | contraindication | 53741008 | DOID:3393 |
| Paralytic ileus | contraindication | 55525008 | DOID:8442 |
| Peptic reflux disease | contraindication | 57643001 | |
| Hepatic failure | contraindication | 59927004 | |
| Ulcerative colitis | contraindication | 64766004 | DOID:8577 |
| Arterial thrombosis | contraindication | 65198009 | |
| Drug AND/OR toxin-induced diarrhea | contraindication | 65979008 | |
| Substance abuse | contraindication | 66214007 | |
| Benign intracranial hypertension | contraindication | 68267002 | DOID:11459 |
| Poisoning by acetaminophen | contraindication | 70273001 | |
| Arteriosclerotic vascular disease | contraindication | 72092001 | |
| Diabetes mellitus | contraindication | 73211009 | DOID:9351 |
| Urethral stricture | contraindication | 76618002 | |
| Spastic paralysis | contraindication | 78403003 | |
| Disturbance of salivary secretion | contraindication | 78948009 | |
| Decreased respiratory function | contraindication | 80954004 | |
| Injury of head | contraindication | 82271004 | |
| Chronic idiopathic constipation | contraindication | 82934008 | |
| Cor pulmonale | contraindication | 83291003 | DOID:8515 |
| Hiatal hernia | contraindication | 84089009 | DOID:12642 |
| Epilepsy | contraindication | 84757009 | DOID:1826 |
| Pulmonary emphysema | contraindication | 87433001 | |
| Kidney disease | contraindication | 90708001 | DOID:557 |
| Myasthenia gravis | contraindication | 91637004 | DOID:437 |
| Acute abdominal pain | contraindication | 116290004 | |
| Procedure on urinary system | contraindication | 118677009 | |
| Gastrointestinal obstruction | contraindication | 126765001 | |
| Neoplasm of brain | contraindication | 126952004 | DOID:1319 |
| Seizure disorder | contraindication | 128613002 | |
| Autonomic dysreflexia | contraindication | 129618003 | |
| Bleeding | contraindication | 131148009 | |
| Drug-induced psychosis | contraindication | 191483003 | DOID:1742 |
| Partial atrioventricular block | contraindication | 195039008 | |
| Acute pancreatitis | contraindication | 197456007 | DOID:2913 |
| Myocardial dysfunction | contraindication | 233928007 | |
| Disease of liver | contraindication | 235856003 | DOID:409 |
| Bladder outflow obstruction | contraindication | 236645006 | |
| Morbid obesity | contraindication | 238136002 | DOID:11981 |
| Pyloric obstruction | contraindication | 244815007 | |
| Benign prostatic hyperplasia | contraindication | 266569009 | |
| Retention of urine | contraindication | 267064002 | |
| Drowsy | contraindication | 271782001 | |
| Exacerbation of asthma | contraindication | 281239006 | |
| Lesion of brain | contraindication | 301766008 | |
| Coma | contraindication | 371632003 | |
| Primary adrenocortical insufficiency | contraindication | 373662000 | |
| Operation on gastrointestinal tract | contraindication | 386621005 | |
| Hypoxia | contraindication | 389086002 | |
| Angle-closure glaucoma | contraindication | 392291006 | DOID:13550 |
| Pseudomembranous enterocolitis | contraindication | 397683000 | |
| Gastric ulcer | contraindication | 397825006 | DOID:10808 |
| Breastfeeding (mother) | contraindication | 413712001 | |
| Chronic lung disease | contraindication | 413839001 | |
| Disorder of coronary artery | contraindication | 414024009 | |
| Central nervous system depression | contraindication | 418072004 | |
| Ultrarapid metabolizer due to cytochrome p450 CYP2D6 variant | contraindication | 422681000 | |
| Dysfunction of sphincter of Oddi | contraindication | 430887001 | |
| Hypertensive urgency | contraindication | 443482000 | |
| Acute exacerbation of asthma | contraindication | 708038006 |
🐶 Veterinary Drug Use
None
🐶 Veterinary products
None
Acid dissociation constants calculated using MoKa v3.0.0
| Dissociation level | Dissociation constant | Type (acidic/basic) |
|---|---|---|
| pKa1 | 9.47 | Basic |
| pKa2 | 4.14 | Basic |
Orange Book patent data (new drug applications)
None
Orange Book exclusivity data (new drug applications)
None
Bioactivity Summary:
| Target | Class | Pharos | UniProt | Action | Type | Activity value (-log[M]) | Mechanism action | Bioact source | MoA source |
|---|---|---|---|---|---|---|---|---|---|
| Histamine H1 receptor | GPCR | ANTAGONIST | Ki | 8.22 | PDSP | CHEMBL | |||
| Potassium voltage-gated channel subfamily H member 2 | Ion channel | IC50 | 6.05 | CHEMBL | |||||
| Sodium channel alpha subunits; brain (Types I, II, III) | Ion channel | IC50 | 4.96 | CHEMBL |
External reference:
| ID | Source |
|---|---|
| 4019641 | VUID |
| N0000147734 | NUI |
| D00663 | KEGG_DRUG |
| 980-71-2 | SECONDARY_CAS_RN |
| 142427 | RXNORM |
| C0006246 | UMLSCUI |
| CHEBI:3183 | CHEBI |
| CHEMBL811 | ChEMBL_ID |
| DB00835 | DRUGBANK_ID |
| CHEMBL1200961 | ChEMBL_ID |
| D001977 | MESH_DESCRIPTOR_UI |
| 6834 | PUBCHEM_CID |
| 7133 | IUPHAR_LIGAND_ID |
| 770 | INN_ID |
| H57G17P2FN | UNII |
| 3426 | MMSL |
| 4302 | MMSL |
| d00785 | MMSL |
| 29588002 | SNOMEDCT_US |
| 372775001 | SNOMEDCT_US |
| 56480005 | SNOMEDCT_US |
| 4017852 | VANDF |
| 4019641 | VANDF |
| 003389 | NDDF |
| 004795 | NDDF |
Pharmaceutical products:
| Product | Category | Ingredients | NDC | Form | Quantity | Route | Marketing | Label |
|---|---|---|---|---|---|---|---|---|
| Dimetapp | HUMAN OTC DRUG LABEL | 2 | 0031-2231 | ELIXIR | 1 mg | ORAL | Export only | 15 sections |
| Dimetapp | HUMAN OTC DRUG LABEL | 2 | 0031-2231 | ELIXIR | 1 mg | ORAL | Export only | 15 sections |
| CHILDRENS DIMETAPP COLD AND COUGH | HUMAN OTC DRUG LABEL | 3 | 0031-2234 | LIQUID | 1 mg | ORAL | OTC monograph final | 16 sections |
| CHILDRENS DIMETAPP COLD AND ALLERGY | HUMAN OTC DRUG LABEL | 2 | 0031-2235 | LIQUID | 1 mg | ORAL | OTC monograph final | 16 sections |
| Dimetapp Paediatric | HUMAN OTC DRUG LABEL | 2 | 0031-2251 | ELIXIR | 1 mg | ORAL | Export only | 1 sections |
| Dimetapp Paediatric | HUMAN OTC DRUG LABEL | 2 | 0031-2251 | ELIXIR | 1 mg | ORAL | Export only | 1 sections |
| Good Sense Childrens Cold and Cough | HUMAN OTC DRUG LABEL | 3 | 0113-0987 | SOLUTION | 2 mg | ORAL | OTC monograph final | 16 sections |
| Brompheniramine Maleate, Pseudoephedrine Hydrochloride and Dextromethorphan Hydrobromide | HUMAN PRESCRIPTION DRUG LABEL | 3 | 0121-0933 | SOLUTION | 2 mg | ORAL | ANDA | 21 sections |
| Brompheniramine Maleate, Pseudoephedrine Hydrochloride and Dextromethorphan Hydrobromide | HUMAN PRESCRIPTION DRUG LABEL | 3 | 0121-0933 | SOLUTION | 2 mg | ORAL | ANDA | 21 sections |
| Childrens Wal Tap ElixerCold and Allergy | HUMAN OTC DRUG LABEL | 2 | 0363-0312 | LIQUID | 2 mg | ORAL | OTC MONOGRAPH FINAL | 16 sections |
| Childrens Wal Tap ElixerCold and Allergy | HUMAN OTC DRUG LABEL | 2 | 0363-0312 | LIQUID | 2 mg | ORAL | OTC MONOGRAPH FINAL | 16 sections |
| Childrens Wal Tap ElixerCold and Allergy | HUMAN OTC DRUG LABEL | 2 | 0363-0312 | LIQUID | 2 mg | ORAL | OTC MONOGRAPH FINAL | 16 sections |
| childrens wal tapdm cough and cold | HUMAN OTC DRUG LABEL | 3 | 0363-0708 | SOLUTION | 2 mg | ORAL | OTC monograph final | 16 sections |
| RYNEX PE | HUMAN OTC DRUG LABEL | 2 | 0485-0202 | LIQUID | 1 mg | ORAL | OTC monograph final | 16 sections |
| RYNEX PE | HUMAN OTC DRUG LABEL | 2 | 0485-0202 | LIQUID | 1 mg | ORAL | OTC monograph final | 16 sections |
| Rynex DM | HUMAN OTC DRUG LABEL | 3 | 0485-0204 | LIQUID | 1 mg | ORAL | OTC monograph final | 16 sections |
| Rynex DM | HUMAN OTC DRUG LABEL | 3 | 0485-0204 | LIQUID | 1 mg | ORAL | OTC monograph final | 16 sections |
| Rynex DM | HUMAN OTC DRUG LABEL | 3 | 0485-0204 | LIQUID | 1 mg | ORAL | OTC monograph final | 16 sections |
| RYNEX PSE | HUMAN OTC DRUG LABEL | 2 | 0485-0206 | LIQUID | 1 mg | ORAL | OTC monograph final | 14 sections |
| RYNEX PSE | HUMAN OTC DRUG LABEL | 2 | 0485-0206 | LIQUID | 1 mg | ORAL | OTC monograph final | 14 sections |
| Brompheniramine Maleate, Pseudoephedrine Hydrochloride, and Dextromethorphan Hydrobromide | HUMAN PRESCRIPTION DRUG LABEL | 3 | 0527-5302 | SYRUP | 2 mg | ORAL | ANDA | 12 sections |
| Brompheniramine Maleate, Pseudoephedrine Hydrochloride, and Dextromethorphan Hydrobromide | HUMAN PRESCRIPTION DRUG LABEL | 3 | 0527-5302 | SYRUP | 2 mg | ORAL | ANDA | 12 sections |
| Brompheniramine Maleate, Pseudoephedrine Hydrochloride and Dextromethorphan Hydrobromide | HUMAN PRESCRIPTION DRUG LABEL | 3 | 0574-1104 | SYRUP | 2 mg | ORAL | ANDA | 19 sections |
| Brompheniramine Maleate, Pseudoephedrine Hydrochloride and Dextromethorphan Hydrobromide | HUMAN PRESCRIPTION DRUG LABEL | 3 | 0574-1104 | SYRUP | 2 mg | ORAL | ANDA | 19 sections |
| Mar-cof BP | HUMAN OTC DRUG LABEL | 3 | 0682-0480 | SYRUP | 2 mg | ORAL | OTC MONOGRAPH FINAL | 16 sections |
| dimaphen dm | HUMAN OTC DRUG LABEL | 3 | 0904-6463 | SOLUTION | 2 mg | ORAL | OTC monograph final | 16 sections |
| up and up childrens cold and cough | HUMAN OTC DRUG LABEL | 3 | 11673-987 | SOLUTION | 1 mg | ORAL | OTC monograph final | 16 sections |
| Cold and CoughChildrens | HUMAN OTC DRUG LABEL | 3 | 11822-5259 | LIQUID | 2 mg | ORAL | OTC monograph final | 15 sections |
| M-ENDPE | HUMAN OTC DRUG LABEL | 3 | 12830-754 | LIQUID | 1.33 mg | ORAL | OTC monograph final | 16 sections |
| M-ENDPE | HUMAN OTC DRUG LABEL | 3 | 12830-754 | LIQUID | 1.33 mg | ORAL | OTC monograph final | 16 sections |