Stem definition | Drug id | CAS RN |
---|---|---|
4411 | 25523-97-1 |
Dose | Unit | Route |
---|---|---|
6 | mg | O |
6 | mg | P |
None
Date | Agency | Company | Orphan |
---|---|---|---|
July 14, 1981 | FDA |
MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
---|---|---|---|---|---|---|
Erythema | 348.91 | 26.12 | 227 | 6642 | 146187 | 50452068 |
Infusion related reaction | 188.51 | 26.12 | 167 | 6702 | 169390 | 50428865 |
Hypersensitivity | 154.79 | 26.12 | 167 | 6702 | 214994 | 50383261 |
Hepatocellular injury | 140.12 | 26.12 | 69 | 6800 | 25878 | 50572377 |
Anaphylactic shock | 119.04 | 26.12 | 57 | 6812 | 20098 | 50578157 |
Sense of oppression | 91.35 | 26.12 | 22 | 6847 | 923 | 50597332 |
Oxygen saturation decreased | 78.79 | 26.12 | 71 | 6798 | 73177 | 50525078 |
Cytokine release syndrome | 78.39 | 26.12 | 33 | 6836 | 8601 | 50589654 |
Pyrexia | 75.82 | 26.12 | 162 | 6707 | 380041 | 50218214 |
Febrile neutropenia | 75.58 | 26.12 | 79 | 6790 | 97588 | 50500667 |
Rash maculo-papular | 62.27 | 26.12 | 41 | 6828 | 26600 | 50571655 |
Hyperthermia | 58.67 | 26.12 | 26 | 6843 | 7670 | 50590585 |
Dyspnoea | 58 | 26.12 | 184 | 6685 | 547424 | 50050831 |
Neutrophil count decreased | 56.25 | 26.12 | 48 | 6821 | 45978 | 50552277 |
Drug ineffective | 54.15 | 26.12 | 22 | 6847 | 819311 | 49778944 |
Hypertension | 52.73 | 26.12 | 99 | 6770 | 211104 | 50387151 |
Fatigue | 51.84 | 26.12 | 16 | 6853 | 707585 | 49890670 |
Chest discomfort | 51.24 | 26.12 | 63 | 6806 | 92659 | 50505596 |
Hypotension | 44.08 | 26.12 | 98 | 6771 | 235371 | 50362884 |
Wrong patient received product | 39.65 | 26.12 | 13 | 6856 | 1687 | 50596568 |
Pruritus | 39.19 | 26.12 | 105 | 6764 | 283463 | 50314792 |
Cholestasis | 38.40 | 26.12 | 30 | 6839 | 25371 | 50572884 |
Feeling hot | 38.22 | 26.12 | 36 | 6833 | 39166 | 50559089 |
Bronchospasm | 37.50 | 26.12 | 24 | 6845 | 14830 | 50583425 |
Hepatic function abnormal | 35.72 | 26.12 | 32 | 6837 | 32649 | 50565606 |
Tachycardia | 34.36 | 26.12 | 54 | 6815 | 99709 | 50498546 |
Chills | 32.83 | 26.12 | 52 | 6817 | 96635 | 50501620 |
Platelet count decreased | 32.60 | 26.12 | 53 | 6816 | 100673 | 50497582 |
Urticaria | 32.59 | 26.12 | 61 | 6808 | 129500 | 50468755 |
Lymphopenia | 31.62 | 26.12 | 22 | 6847 | 15599 | 50582656 |
Malaise | 31.08 | 26.12 | 108 | 6761 | 335424 | 50262831 |
Serum sickness | 30.99 | 26.12 | 12 | 6857 | 2520 | 50595735 |
Psychiatric decompensation | 30.88 | 26.12 | 10 | 6859 | 1248 | 50597007 |
Cytomegalovirus infection | 28.86 | 26.12 | 22 | 6847 | 17940 | 50580315 |
Febrile bone marrow aplasia | 28.81 | 26.12 | 15 | 6854 | 6296 | 50591959 |
Pain | 28.81 | 26.12 | 22 | 6847 | 578881 | 50019374 |
Persecutory delusion | 28.11 | 26.12 | 11 | 6858 | 2376 | 50595879 |
Anaphylactoid reaction | 27.55 | 26.12 | 12 | 6857 | 3394 | 50594861 |
Mixed liver injury | 27.40 | 26.12 | 12 | 6857 | 3439 | 50594816 |
MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
---|---|---|---|---|---|---|
Febrile bone marrow aplasia | 138.37 | 22.54 | 55 | 6754 | 7296 | 29560422 |
Infusion related reaction | 130.79 | 22.54 | 96 | 6713 | 43790 | 29523928 |
Erythema | 122.15 | 22.54 | 116 | 6693 | 75490 | 29492228 |
Hypersensitivity | 121.17 | 22.54 | 99 | 6710 | 52804 | 29514914 |
Febrile neutropenia | 105.04 | 22.54 | 129 | 6680 | 112111 | 29455607 |
Cytokine release syndrome | 85.17 | 22.54 | 47 | 6762 | 13072 | 29554646 |
Anaphylactic shock | 76.34 | 22.54 | 44 | 6765 | 13292 | 29554426 |
Alveolar lung disease | 73.19 | 22.54 | 17 | 6792 | 352 | 29567366 |
Pulmonary interstitial emphysema syndrome | 69.24 | 22.54 | 17 | 6792 | 449 | 29567269 |
Generalised oedema | 67.02 | 22.54 | 38 | 6771 | 11127 | 29556591 |
Pyrexia | 66.17 | 22.54 | 179 | 6630 | 287443 | 29280275 |
Hyperthermia | 56.33 | 22.54 | 32 | 6777 | 9398 | 29558320 |
Neutropenia | 51.22 | 22.54 | 101 | 6708 | 131610 | 29436108 |
Diffuse alveolar damage | 48.10 | 22.54 | 18 | 6791 | 2025 | 29565693 |
Chills | 45.26 | 22.54 | 68 | 6741 | 71232 | 29496486 |
Face oedema | 43.59 | 22.54 | 28 | 6781 | 10255 | 29557463 |
Kounis syndrome | 42.64 | 22.54 | 16 | 6793 | 1813 | 29565905 |
Hyperammonaemia | 41.50 | 22.54 | 22 | 6787 | 5641 | 29562077 |
Fatigue | 41.42 | 22.54 | 11 | 6798 | 316810 | 29250908 |
Sense of oppression | 39.48 | 22.54 | 11 | 6798 | 480 | 29567238 |
Eosinophilic pneumonia | 39.03 | 22.54 | 17 | 6792 | 2829 | 29564889 |
Necrotising retinitis | 38.80 | 22.54 | 12 | 6797 | 756 | 29566962 |
Interstitial lung disease | 35.12 | 22.54 | 54 | 6755 | 57664 | 29510054 |
Cytomegalovirus test positive | 32.98 | 22.54 | 16 | 6793 | 3407 | 29564311 |
Oxygen saturation decreased | 31.59 | 22.54 | 45 | 6764 | 44892 | 29522826 |
Cardiac ventricular disorder | 31.57 | 22.54 | 8 | 6801 | 241 | 29567477 |
Disseminated intravascular coagulation | 30.90 | 22.54 | 30 | 6779 | 19950 | 29547768 |
Abdominal compartment syndrome | 29.67 | 22.54 | 10 | 6799 | 829 | 29566889 |
Malaise | 29.41 | 22.54 | 92 | 6717 | 159510 | 29408208 |
Platelet count decreased | 28.90 | 22.54 | 70 | 6739 | 104602 | 29463116 |
Rash | 28.41 | 22.54 | 102 | 6707 | 189717 | 29378001 |
Hypoxia | 28.36 | 22.54 | 44 | 6765 | 47335 | 29520383 |
Acute coronary syndrome | 28.00 | 22.54 | 23 | 6786 | 12302 | 29555416 |
Cytomegalovirus infection | 27.14 | 22.54 | 30 | 6779 | 23185 | 29544533 |
Blood immunoglobulin G decreased | 26.51 | 22.54 | 10 | 6799 | 1149 | 29566569 |
Drug ineffective | 26.33 | 22.54 | 27 | 6782 | 363143 | 29204575 |
Tumour lysis syndrome | 25.61 | 22.54 | 23 | 6786 | 13861 | 29553857 |
Neutrophil count decreased | 25.43 | 22.54 | 40 | 6769 | 43527 | 29524191 |
Eosinophilia | 24.81 | 22.54 | 28 | 6781 | 22133 | 29545585 |
Rash maculo-papular | 24.37 | 22.54 | 29 | 6780 | 24260 | 29543458 |
Urticaria | 23.73 | 22.54 | 44 | 6765 | 54616 | 29513102 |
White blood cell count decreased | 23.26 | 22.54 | 56 | 6753 | 83306 | 29484412 |
Pruritus | 23.02 | 22.54 | 69 | 6740 | 116780 | 29450938 |
Hepatic function abnormal | 22.84 | 22.54 | 36 | 6773 | 39223 | 29528495 |
MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
---|---|---|---|---|---|---|
Erythema | 420.37 | 19.66 | 335 | 13446 | 186735 | 64298216 |
Infusion related reaction | 305.44 | 19.66 | 264 | 13517 | 164203 | 64320748 |
Hypersensitivity | 254.18 | 19.66 | 258 | 13523 | 196194 | 64288757 |
Anaphylactic shock | 169.55 | 19.66 | 96 | 13685 | 30232 | 64454719 |
Febrile neutropenia | 156.01 | 19.66 | 196 | 13585 | 187461 | 64297490 |
Cytokine release syndrome | 147.15 | 19.66 | 77 | 13704 | 20752 | 64464199 |
Febrile bone marrow aplasia | 129.13 | 19.66 | 58 | 13723 | 11197 | 64473754 |
Hepatocellular injury | 127.48 | 19.66 | 93 | 13688 | 45142 | 64439809 |
Sense of oppression | 121.47 | 19.66 | 33 | 13748 | 1414 | 64483537 |
Pyrexia | 121.46 | 19.66 | 325 | 13456 | 558319 | 63926632 |
Hyperthermia | 105.60 | 19.66 | 56 | 13725 | 15494 | 64469457 |
Oxygen saturation decreased | 90.57 | 19.66 | 113 | 13668 | 107063 | 64377888 |
Fatigue | 85.59 | 19.66 | 27 | 13754 | 748703 | 63736248 |
Rash maculo-papular | 76.06 | 19.66 | 70 | 13711 | 46956 | 64437995 |
Chills | 75.89 | 19.66 | 118 | 13663 | 137146 | 64347805 |
Neutrophil count decreased | 74.35 | 19.66 | 87 | 13694 | 77109 | 64407842 |
Pulmonary interstitial emphysema syndrome | 70.60 | 19.66 | 17 | 13764 | 446 | 64484505 |
Alveolar lung disease | 68.10 | 19.66 | 17 | 13764 | 520 | 64484431 |
Toxicity to various agents | 65.11 | 19.66 | 3 | 13778 | 363510 | 64121441 |
Drug ineffective | 64.95 | 19.66 | 51 | 13730 | 840196 | 63644755 |
Hypertension | 62.33 | 19.66 | 157 | 13624 | 259104 | 64225847 |
Platelet count decreased | 61.12 | 19.66 | 120 | 13661 | 167591 | 64317360 |
Neutropenia | 55.39 | 19.66 | 143 | 13638 | 239481 | 64245470 |
Hepatic function abnormal | 54.59 | 19.66 | 68 | 13713 | 64245 | 64420706 |
Pruritus | 51.43 | 19.66 | 165 | 13616 | 312235 | 64172716 |
Generalised oedema | 50.11 | 19.66 | 39 | 13742 | 20814 | 64464137 |
Dyspnoea | 49.93 | 19.66 | 292 | 13489 | 718382 | 63766569 |
Malaise | 49.47 | 19.66 | 191 | 13590 | 396056 | 64088895 |
Face oedema | 48.29 | 19.66 | 41 | 13740 | 24720 | 64460231 |
Feeling hot | 48.22 | 19.66 | 54 | 13727 | 45609 | 64439342 |
Hypotension | 47.85 | 19.66 | 184 | 13597 | 380790 | 64104161 |
Interstitial lung disease | 47.12 | 19.66 | 79 | 13702 | 97653 | 64387298 |
White blood cell count decreased | 47.03 | 19.66 | 104 | 13677 | 157733 | 64327218 |
Bronchospasm | 46.64 | 19.66 | 38 | 13743 | 21644 | 64463307 |
Cytomegalovirus infection | 46.32 | 19.66 | 48 | 13733 | 37151 | 64447800 |
Urticaria | 46.09 | 19.66 | 99 | 13682 | 147218 | 64337733 |
Tumour lysis syndrome | 45.93 | 19.66 | 36 | 13745 | 19404 | 64465547 |
Diffuse alveolar damage | 41.38 | 19.66 | 18 | 13763 | 3217 | 64481734 |
Hyperammonaemia | 41.36 | 19.66 | 26 | 13755 | 9878 | 64475073 |
Pain | 40.90 | 19.66 | 35 | 13746 | 553476 | 63931475 |
Cytomegalovirus test positive | 39.14 | 19.66 | 20 | 13761 | 5124 | 64479827 |
Serum sickness | 38.38 | 19.66 | 17 | 13764 | 3172 | 64481779 |
Disseminated intravascular coagulation | 37.18 | 19.66 | 40 | 13741 | 32308 | 64452643 |
Thrombocytopenia | 36.59 | 19.66 | 118 | 13663 | 223683 | 64261268 |
Chest discomfort | 36.26 | 19.66 | 78 | 13703 | 116028 | 64368923 |
Kounis syndrome | 36.00 | 19.66 | 16 | 13765 | 3009 | 64481942 |
Necrotising retinitis | 35.84 | 19.66 | 12 | 13769 | 1051 | 64483900 |
Septic shock | 35.45 | 19.66 | 73 | 13708 | 105364 | 64379587 |
Anaphylactoid reaction | 34.83 | 19.66 | 18 | 13763 | 4720 | 64480231 |
Hypoxia | 34.43 | 19.66 | 65 | 13716 | 88084 | 64396867 |
Tachycardia | 34.23 | 19.66 | 89 | 13692 | 149490 | 64335461 |
Arthralgia | 32.60 | 19.66 | 28 | 13753 | 442232 | 64042719 |
Eosinophilic pneumonia | 32.53 | 19.66 | 17 | 13764 | 4560 | 64480391 |
Anaphylactic reaction | 32.41 | 19.66 | 55 | 13726 | 68609 | 64416342 |
Acute coronary syndrome | 31.70 | 19.66 | 29 | 13752 | 19281 | 64465670 |
Product dose omission issue | 30.78 | 19.66 | 3 | 13778 | 194744 | 64290207 |
Upper respiratory tract inflammation | 29.63 | 19.66 | 15 | 13766 | 3767 | 64481184 |
Cardiac ventricular disorder | 29.62 | 19.66 | 8 | 13773 | 335 | 64484616 |
Pain in extremity | 29.41 | 19.66 | 14 | 13767 | 303071 | 64181880 |
Dizziness | 28.46 | 19.66 | 30 | 13751 | 430133 | 64054818 |
Rash | 28.32 | 19.66 | 181 | 13600 | 458368 | 64026583 |
Oropharyngeal discomfort | 27.41 | 19.66 | 16 | 13765 | 5319 | 64479632 |
Hyperamylasaemia | 25.90 | 19.66 | 9 | 13772 | 882 | 64484069 |
Enterocolitis | 25.71 | 19.66 | 21 | 13760 | 11997 | 64472954 |
Eosinophilia | 25.71 | 19.66 | 36 | 13745 | 38040 | 64446911 |
Abdominal compartment syndrome | 25.21 | 19.66 | 10 | 13771 | 1418 | 64483533 |
Drug intolerance | 24.79 | 19.66 | 5 | 13776 | 187987 | 64296964 |
Cyanosis | 24.76 | 19.66 | 27 | 13754 | 22128 | 64462823 |
Sepsis | 24.66 | 19.66 | 106 | 13675 | 230235 | 64254716 |
Condition aggravated | 24.60 | 19.66 | 26 | 13755 | 372400 | 64112551 |
Mucosal inflammation | 24.24 | 19.66 | 46 | 13735 | 62538 | 64422413 |
Wrong patient received product | 23.99 | 19.66 | 13 | 13768 | 3749 | 64481202 |
Lung disorder | 23.99 | 19.66 | 45 | 13736 | 60655 | 64424296 |
Cholestasis | 23.95 | 19.66 | 38 | 13743 | 44834 | 64440117 |
Hypothermia | 23.60 | 19.66 | 25 | 13756 | 19831 | 64465120 |
Lymphopenia | 23.16 | 19.66 | 28 | 13753 | 25629 | 64459322 |
Weight increased | 22.03 | 19.66 | 9 | 13772 | 213339 | 64271612 |
Type I hypersensitivity | 21.82 | 19.66 | 12 | 13769 | 3562 | 64481389 |
Abdominal discomfort | 21.77 | 19.66 | 6 | 13775 | 182316 | 64302635 |
Swelling | 21.68 | 19.66 | 4 | 13777 | 160214 | 64324737 |
Drug reaction with eosinophilia and systemic symptoms | 21.18 | 19.66 | 40 | 13741 | 54177 | 64430774 |
Larynx irritation | 21.03 | 19.66 | 5 | 13776 | 124 | 64484827 |
Psychiatric decompensation | 19.98 | 19.66 | 10 | 13771 | 2453 | 64482498 |
None
Source | Code | Description |
---|---|---|
ATC | R06AB02 | RESPIRATORY SYSTEM ANTIHISTAMINES FOR SYSTEMIC USE ANTIHISTAMINES FOR SYSTEMIC USE Substituted alkylamines |
ATC | R06AB52 | RESPIRATORY SYSTEM ANTIHISTAMINES FOR SYSTEMIC USE ANTIHISTAMINES FOR SYSTEMIC USE Substituted alkylamines |
MeSH PA | D018494 | Histamine Agents |
MeSH PA | D006633 | Histamine Antagonists |
MeSH PA | D006634 | Histamine H1 Antagonists |
MeSH PA | D018377 | Neurotransmitter Agents |
Disease | Relation | SNOMED_ID | DOID |
---|---|---|---|
Dermatographic urticaria | indication | 7632005 | DOID:743 |
Vasomotor rhinitis | indication | 8229003 | DOID:4730 |
Allergic rhinitis | indication | 61582004 | |
Urticaria | indication | 126485001 | |
Seasonal allergic rhinitis | indication | 367498001 | |
Itching of skin | indication | 418363000 | |
Allergic conjunctivitis | indication | 473460002 | DOID:11204 |
Brain damage | contraindication | 2470005 | |
Ocular hypertension | contraindication | 4210003 | DOID:9282 |
Tachyarrhythmia | contraindication | 6285003 | |
Suicidal thoughts | contraindication | 6471006 | |
Dependent drug abuse | contraindication | 6525002 | |
Urinary tract obstruction | contraindication | 7163005 | DOID:5200 |
Alcoholism | contraindication | 7200002 | |
Alcohol withdrawal delirium | contraindication | 8635005 | |
Peptic ulcer | contraindication | 13200003 | DOID:750 |
Asthenia | contraindication | 13791008 | |
Severe chronic ulcerative colitis | contraindication | 14311001 | |
Constipation | contraindication | 14760008 | DOID:2089 |
Chronic disease of respiratory system | contraindication | 17097001 | |
Mood swings | contraindication | 18963009 | |
Myocardial infarction | contraindication | 22298006 | DOID:5844 |
Inflammatory bowel disease | contraindication | 24526004 | DOID:0050589 |
Ventricular tachycardia | contraindication | 25569003 | |
Alcohol intoxication | contraindication | 25702006 | |
Shock | contraindication | 27942005 | |
Toxic megacolon | contraindication | 28536002 | DOID:1770 |
Atony of colon | contraindication | 29479008 | |
Hypercapnia | contraindication | 29596007 | |
Dehydration | contraindication | 34095006 | |
Hyperthyroidism | contraindication | 34486009 | DOID:7998 |
Acute hepatitis | contraindication | 37871000 | |
Hypertensive disorder | contraindication | 38341003 | DOID:10763 |
Disorder of gallbladder | contraindication | 39621005 | DOID:0060262 |
Hypothyroidism | contraindication | 40930008 | DOID:1459 |
Complete trisomy 21 syndrome | contraindication | 41040004 | DOID:14250 |
Conduction disorder of the heart | contraindication | 44808001 | |
Low blood pressure | contraindication | 45007003 | |
Achalasia of esophagus | contraindication | 45564002 | DOID:9164 |
Chronic heart failure | contraindication | 48447003 | |
Bradycardia | contraindication | 48867003 | |
Disorder of cardiovascular system | contraindication | 49601007 | DOID:1287 |
Acidosis | contraindication | 51387008 | |
Coronary arteriosclerosis | contraindication | 53741008 | DOID:3393 |
Paralytic ileus | contraindication | 55525008 | DOID:8442 |
Peptic reflux disease | contraindication | 57643001 | |
Hepatic failure | contraindication | 59927004 | |
Ulcerative colitis | contraindication | 64766004 | DOID:8577 |
Arterial thrombosis | contraindication | 65198009 | |
Drug AND/OR toxin-induced diarrhea | contraindication | 65979008 | |
Substance abuse | contraindication | 66214007 | |
Benign intracranial hypertension | contraindication | 68267002 | DOID:11459 |
Poisoning by acetaminophen | contraindication | 70273001 | |
Arteriosclerotic vascular disease | contraindication | 72092001 | |
Diabetes mellitus | contraindication | 73211009 | DOID:9351 |
Urethral stricture | contraindication | 76618002 | |
Spastic paralysis | contraindication | 78403003 | |
Disturbance of salivary secretion | contraindication | 78948009 | |
Decreased respiratory function | contraindication | 80954004 | |
Injury of head | contraindication | 82271004 | |
Chronic idiopathic constipation | contraindication | 82934008 | |
Cor pulmonale | contraindication | 83291003 | DOID:8515 |
Hiatal hernia | contraindication | 84089009 | DOID:12642 |
Epilepsy | contraindication | 84757009 | DOID:1826 |
Pulmonary emphysema | contraindication | 87433001 | |
Kidney disease | contraindication | 90708001 | DOID:557 |
Myasthenia gravis | contraindication | 91637004 | DOID:437 |
Acute abdominal pain | contraindication | 116290004 | |
Procedure on urinary system | contraindication | 118677009 | |
Gastrointestinal obstruction | contraindication | 126765001 | |
Neoplasm of brain | contraindication | 126952004 | DOID:1319 |
Seizure disorder | contraindication | 128613002 | |
Autonomic dysreflexia | contraindication | 129618003 | |
Bleeding | contraindication | 131148009 | |
Drug-induced psychosis | contraindication | 191483003 | DOID:1742 |
Partial atrioventricular block | contraindication | 195039008 | |
Acute pancreatitis | contraindication | 197456007 | DOID:2913 |
Myocardial dysfunction | contraindication | 233928007 | |
Disease of liver | contraindication | 235856003 | DOID:409 |
Bladder outflow obstruction | contraindication | 236645006 | |
Morbid obesity | contraindication | 238136002 | DOID:11981 |
Pyloric obstruction | contraindication | 244815007 | |
Benign prostatic hyperplasia | contraindication | 266569009 | |
Retention of urine | contraindication | 267064002 | |
Drowsy | contraindication | 271782001 | |
Exacerbation of asthma | contraindication | 281239006 | |
Lesion of brain | contraindication | 301766008 | |
Coma | contraindication | 371632003 | |
Primary adrenocortical insufficiency | contraindication | 373662000 | |
Operation on gastrointestinal tract | contraindication | 386621005 | |
Hypoxia | contraindication | 389086002 | |
Angle-closure glaucoma | contraindication | 392291006 | DOID:13550 |
Pseudomembranous enterocolitis | contraindication | 397683000 | |
Gastric ulcer | contraindication | 397825006 | DOID:10808 |
Breastfeeding (mother) | contraindication | 413712001 | |
Chronic lung disease | contraindication | 413839001 | |
Disorder of coronary artery | contraindication | 414024009 | |
Central nervous system depression | contraindication | 418072004 | |
Ultrarapid metabolizer due to cytochrome p450 CYP2D6 variant | contraindication | 422681000 | |
Dysfunction of sphincter of Oddi | contraindication | 430887001 | |
Hypertensive urgency | contraindication | 443482000 | |
Acute exacerbation of asthma | contraindication | 708038006 |
None
None
Dissociation level | Dissociation constant | Type (acidic/basic) |
---|---|---|
pKa1 | 9.47 | Basic |
pKa2 | 4.14 | Basic |
None
None
Target | Class | Pharos | UniProt | Action | Type | Activity value (-log[M]) | Mechanism action | Bioact source | MoA source |
---|---|---|---|---|---|---|---|---|---|
Histamine H1 receptor | GPCR | ANTAGONIST | Ki | 9.14 | CHEMBL | CHEMBL | |||
Sigma non-opioid intracellular receptor 1 | Membrane receptor | Ki | 6.16 | DRUG MATRIX | |||||
Sodium-dependent serotonin transporter | Transporter | Ki | 7.89 | DRUG MATRIX | |||||
Sodium-dependent noradrenaline transporter | Transporter | Ki | 5.31 | DRUG MATRIX | |||||
5-hydroxytryptamine receptor 2A | GPCR | Ki | 5.98 | DRUG MATRIX | |||||
5-hydroxytryptamine receptor 2C | GPCR | Ki | 5.92 | DRUG MATRIX | |||||
Alpha-2B adrenergic receptor | GPCR | Ki | 5.68 | DRUG MATRIX | |||||
Histamine H2 receptor | GPCR | Ki | 5.09 | DRUG MATRIX | |||||
Muscarinic acetylcholine receptor M1 | GPCR | Ki | 6.48 | DRUG MATRIX | |||||
Muscarinic acetylcholine receptor M2 | GPCR | Ki | 5.60 | DRUG MATRIX | |||||
Muscarinic acetylcholine receptor M3 | GPCR | Ki | 6.26 | DRUG MATRIX | |||||
Muscarinic acetylcholine receptor M4 | GPCR | Ki | 6.56 | DRUG MATRIX | |||||
Muscarinic acetylcholine receptor M5 | GPCR | Ki | 6.13 | DRUG MATRIX | |||||
Sodium-dependent dopamine transporter | Transporter | Ki | 6.13 | DRUG MATRIX | |||||
Alpha-1D adrenergic receptor | GPCR | Ki | 4.78 | DRUG MATRIX | |||||
Alpha-2A adrenergic receptor | GPCR | Ki | 5.12 | DRUG MATRIX | |||||
Alpha-1B adrenergic receptor | GPCR | Ki | 5.07 | DRUG MATRIX | |||||
Membrane-associated progesterone receptor component 1 | Membrane receptor | Ki | 4.93 | DRUG MATRIX |
ID | Source |
---|---|
D07803 | KEGG_DRUG |
4019712 | VUID |
N0000147804 | NUI |
2438-32-6 | SECONDARY_CAS_RN |
4018792 | VANDF |
4019712 | VANDF |
C0057606 | UMLSCUI |
CHEBI:4464 | CHEBI |
CHEMBL1201353 | ChEMBL_ID |
CHEMBL1200927 | ChEMBL_ID |
DB13679 | DRUGBANK_ID |
C018904 | MESH_SUPPLEMENTAL_RECORD_UI |
1210 | IUPHAR_LIGAND_ID |
955 | INN_ID |
3Q9Q0B929N | UNII |
33036 | PUBCHEM_CID |
DB09555 | DRUGBANK_ID |
22697 | RXNORM |
1479 | MMSL |
4556 | MMSL |
d00784 | MMSL |
003393 | NDDF |
004796 | NDDF |
16031005 | SNOMEDCT_US |
372663001 | SNOMEDCT_US |
68680008 | SNOMEDCT_US |
Product | Category | Ingredients | NDC | Form | Quantity | Route | Marketing | Label |
---|---|---|---|---|---|---|---|---|
RYMED | HUMAN OTC DRUG LABEL | 2 | 0485-0080 | TABLET, COATED | 2 mg | ORAL | OTC monograph final | 16 sections |
RYCLORA | HUMAN PRESCRIPTION DRUG LABEL | 1 | 15370-150 | LIQUID | 2 mg | ORAL | ANDA | 13 sections |
Polytussin DM | HUMAN OTC DRUG LABEL | 3 | 50991-492 | SYRUP | 1 mg | ORAL | OTC monograph final | 13 sections |
ABATUSS DMX | HUMAN OTC DRUG LABEL | 3 | 52083-625 | LIQUID | 1 mg | ORAL | OTC monograph final | 10 sections |
DELTUSS DMX Cough Suppressant Nasal Decongestant Antihistamine GRAPE Flavor | HUMAN OTC DRUG LABEL | 3 | 58238-225 | LIQUID | 1 mg | ORAL | OTC monograph final | 16 sections |
DELTUSS DP Nasal Decongestant Antihistamine CHERRY Flavor | HUMAN OTC DRUG LABEL | 2 | 58238-226 | LIQUID | 1 mg | ORAL | OTC monograph final | 16 sections |
VANACOF | HUMAN OTC DRUG LABEL | 3 | 58809-999 | LIQUID | 1 mg | ORAL | OTC monograph final | 16 sections |
Rescon | HUMAN OTC DRUG LABEL | 2 | 64543-097 | TABLET, MULTILAYER | 2 mg | ORAL | OTC monograph final | 15 sections |
POLMON | HUMAN PRESCRIPTION DRUG LABEL | 1 | 64543-600 | SOLUTION | 2 mg | ORAL | ANDA | 14 sections |
PRO-REDAC | HUMAN OTC DRUG LABEL | 3 | 66594-499 | SYRUP | 1 mg | ORAL | OTC monograph final | 16 sections |
chlophedianol hydrochloride, dexchlorpheniramine maleate, and pseudoephedrine hydrochloride | HUMAN OTC DRUG LABEL | 3 | 69367-183 | LIQUID | 1 mg | ORAL | OTC MONOGRAPH FINAL | 17 sections |
WesTussin DM | HUMAN OTC DRUG LABEL | 3 | 69367-334 | SYRUP | 1 mg | ORAL | OTC MONOGRAPH FINAL | 17 sections |