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dexchlorpheniramine 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definition	Drug id	CAS RN
	4411	25523-97-1

Description:

Molecule	Description
Molfile Inchi Smiles Synonyms: dexchlorpheniramine (+)-Chloropheniramine (+)-Chlorpheniramine S-Chlorpheniramine d-Chlorpheniramine dexchlorpheniramine maleate	Molecular weight: 274.79 Formula: C16H19ClN2 CLOGP: 3.15 LIPINSKI: 0 HAC: 2 HDO: 0 TPSA: 16.13 ALOGS: -3.72 ROTB: 5 Status: OFP Legend: OFP - off patent OFM - off market ONP - on patent

Molecule

Description

Molfile Inchi Smiles

Synonyms:

dexchlorpheniramine
(+)-Chloropheniramine
(+)-Chlorpheniramine
S-Chlorpheniramine
d-Chlorpheniramine
dexchlorpheniramine maleate

Molecular weight: 274.79
Formula: C16H19ClN2
CLOGP: 3.15
LIPINSKI: 0
HAC: 2
HDO: 0
TPSA: 16.13
ALOGS: -3.72
ROTB: 5

Status: OFP

Legend:
OFP - off patent
OFM - off market
ONP - on patent

Drug dosage:

Dose	Unit	Route
6	mg	O
6	mg	P

ADMET properties:

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Property	Value	Reference
S (Water solubility)	3 mg/mL	Bocci G, Oprea TI, Benet LZ
BDDCS (Biopharmaceutical Drug Disposition Classification System)	1	Bocci G, Oprea TI, Benet LZ

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Approvals:

Date	Agency	Company	Orphan
July 14, 1981	FDA

FDA Adverse Event Reporting System (Female)

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MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Erythema	336.00	26.91	231	7752	175520	63305519
Infusion related reaction	213.98	26.91	204	7779	245317	63235722
Cytokine release syndrome	159.47	26.91	62	7921	14252	63466787
Hepatocellular injury	153.70	26.91	73	7910	27308	63453731
Hypersensitivity	132.74	26.91	173	7810	292512	63188527
Anaphylactic shock	126.51	26.91	61	7922	23572	63457467
Febrile neutropenia	100.08	26.91	97	7886	118352	63362687
Pyrexia	96.72	26.91	194	7789	470284	63010755
Sense of oppression	91.43	26.91	22	7961	994	63480045
Oxygen saturation decreased	77.52	26.91	74	7909	88511	63392528

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FDA Adverse Event Reporting System (Male)

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MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Cytokine release syndrome	264.29	23.47	121	7932	22756	34926122
Febrile bone marrow aplasia	149.53	23.47	60	7993	8149	34940729
Infusion related reaction	146.72	23.47	111	7942	52946	34895932
Erythema	139.15	23.47	134	7919	88646	34860232
Febrile neutropenia	125.95	23.47	156	7897	136693	34812185
Pyrexia	114.46	23.47	242	7811	332771	34616107
Hypersensitivity	108.73	23.47	99	7954	60936	34887942
Neutropenia	74.47	23.47	131	7922	156647	34792231
Anaphylactic shock	74.06	23.47	46	8007	15895	34932983
Alveolar lung disease	72.41	23.47	17	8036	369	34948509

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FDA Adverse Event Reporting System (Geriatric)

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MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Erythema	426.25	19.69	356	15822	222934	79505276
Cytokine release syndrome	405.07	19.69	180	15998	35818	79692392
Infusion related reaction	337.10	19.69	316	15862	229921	79498289
Hypersensitivity	213.48	19.69	264	15914	261975	79466235
Febrile neutropenia	198.40	19.69	239	15939	230760	79497450
Pyrexia	188.59	19.69	420	15758	678289	79049921
Anaphylactic shock	174.53	19.69	102	16076	35894	79692316
Febrile bone marrow aplasia	152.41	19.69	67	16111	12953	79715257
Hepatocellular injury	139.01	19.69	98	16080	47495	79680715
Sense of oppression	120.58	19.69	33	16145	1533	79726677

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FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

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Source	Code	Description
ATC	R06AB02	RESPIRATORY SYSTEM ANTIHISTAMINES FOR SYSTEMIC USE ANTIHISTAMINES FOR SYSTEMIC USE Substituted alkylamines
ATC	R06AB52	RESPIRATORY SYSTEM ANTIHISTAMINES FOR SYSTEMIC USE ANTIHISTAMINES FOR SYSTEMIC USE Substituted alkylamines
MeSH PA	D018494	Histamine Agents
MeSH PA	D006633	Histamine Antagonists
MeSH PA	D006634	Histamine H1 Antagonists
MeSH PA	D018377	Neurotransmitter Agents

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Drug Use | Suggest Off label Use Form| |View source of the data|

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Disease	Relation	SNOMED_ID	DOID
Dermatographic urticaria	indication	7632005	DOID:743
Vasomotor rhinitis	indication	8229003	DOID:4730
Allergic rhinitis	indication	61582004
Urticaria	indication	126485001
Seasonal allergic rhinitis	indication	367498001
Itching of skin	indication	418363000
Allergic conjunctivitis	indication	473460002	DOID:11204
Brain damage	contraindication	2470005
Ocular hypertension	contraindication	4210003	DOID:9282
Tachyarrhythmia	contraindication	6285003

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🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation level	Dissociation constant	Type (acidic/basic)
pKa1	9.47	Basic
pKa2	4.14	Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

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Target	Class	Pharos	UniProt	Action	Type	Activity value (-log[M])	Bioact source	MoA source
Histamine H1 receptor	GPCR	P35367	HRH1_HUMAN	ANTAGONIST	Ki	9.14	CHEMBL	CHEMBL
Sigma non-opioid intracellular receptor 1	Membrane receptor	Q99720	SGMR1_HUMAN		Ki	6.16	DRUG MATRIX
Sodium-dependent serotonin transporter	Transporter	P31645	SC6A4_HUMAN		Ki	7.89	DRUG MATRIX
Sodium-dependent noradrenaline transporter	Transporter	P23975	SC6A2_HUMAN		Ki	5.31	DRUG MATRIX
5-hydroxytryptamine receptor 2A	GPCR	P28223	5HT2A_HUMAN		Ki	5.98	DRUG MATRIX
5-hydroxytryptamine receptor 2C	GPCR	P28335	5HT2C_HUMAN		Ki	5.92	DRUG MATRIX
Alpha-2B adrenergic receptor	GPCR	P18089	ADA2B_HUMAN		Ki	5.68	DRUG MATRIX
Histamine H2 receptor	GPCR	P25021	HRH2_HUMAN		Ki	5.09	DRUG MATRIX
Muscarinic acetylcholine receptor M1	GPCR	P11229	ACM1_HUMAN		Ki	6.48	DRUG MATRIX
Muscarinic acetylcholine receptor M2	GPCR	P08172	ACM2_HUMAN		Ki	5.60	DRUG MATRIX

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External reference:

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ID	Source
003393	NDDF
004796	NDDF
1210	IUPHAR_LIGAND_ID
1479	MMSL
16031005	SNOMEDCT_US
22697	RXNORM
2438-32-6	SECONDARY_CAS_RN
33036	PUBCHEM_CID
372663001	SNOMEDCT_US
3Q9Q0B929N	UNII

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Pharmaceutical products:

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Product	Category	Ingredients	NDC	Form	Quantity	Route	Marketing	Label
ABATUSS DMX	HUMAN OTC DRUG LABEL	3	52083-625	LIQUID	1 mg	ORAL	OTC monograph final	10 sections
ABATUSS DMX	HUMAN OTC DRUG LABEL	3	52083-625	LIQUID	1 mg	ORAL	OTC monograph final	10 sections
chlophedianol hydrochloride, dexchlorpheniramine maleate, and pseudoephedrine hydrochloride	HUMAN OTC DRUG LABEL	3	69367-183	LIQUID	1 mg	ORAL	OTC MONOGRAPH FINAL	17 sections
DELTUSS DMX Cough Suppressant Nasal Decongestant Antihistamine GRAPE Flavor	HUMAN OTC DRUG LABEL	3	58238-225	LIQUID	1 mg	ORAL	OTC monograph final	16 sections
DELTUSS DP Nasal Decongestant Antihistamine CHERRY Flavor	HUMAN OTC DRUG LABEL	2	58238-226	LIQUID	1 mg	ORAL	OTC monograph final	16 sections
Dexchlorpheniramine Maleate, Phenylephrine HCl	HUMAN OTC DRUG LABEL	2	66576-080	TABLET	2 mg	ORAL	OTC monograph final	8 sections
POLMON	HUMAN PRESCRIPTION DRUG LABEL	1	64543-600	SOLUTION	2 mg	ORAL	ANDA	14 sections
POLMON	HUMAN PRESCRIPTION DRUG LABEL	1	64543-600	SOLUTION	2 mg	ORAL	ANDA	14 sections
Polytussin DM	HUMAN OTC DRUG LABEL	3	50991-492	SYRUP	1 mg	ORAL	OTC monograph final	13 sections
PRO-REDAC	HUMAN OTC DRUG LABEL	3	66594-499	SYRUP	1 mg	ORAL	OTC monograph final	16 sections

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