All FDA-approved EMA-approved PMDA-approved
Target Card Uniprot Example: P23975

insulin icodec 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | PK/Tox | Related Drugs | BioActivity |

Stem definition	Drug id	CAS RN
	5822	None

Description:

Molecule

Description

Molfile Synonyms: insulin icodec insulin icodec-abae awiqli NN1436

Insulin icodec-abae is a human insulin analog for subcutaneous injection produced by a process that includes expression of recombinant DNA in Saccharomyces cerevisiae followed by chemical modification. Insulin icodec-abae differs from human insulin in that the amino acid threonine in position B30 has been omitted, Tyr(A14) has been substituted with Glu and Tyr(B16) and Phe(B25) have been substituted with His. Awiqli binds reversibly to albumin, resulting in a depot in the circulation from which insulin icodec-abae is slowly released. The insulin receptor is activated by insulin icodec-abae leading to a stable glucose-lowering effect over the entire dosing interval of one week. Molecular weight: Formula: CLOGP: LIPINSKI: None HAC: None HDO: None TPSA: ALOGS: ROTB: None

Drug dosage:

None

ADMET properties:

None

Predicted pharmacokinetic/toxicological properties (PK-AZ):

None

Approvals:

Date	Agency	Company	Orphan
March 26, 2026	FDA	Novo Nordisk Inc.
May 17, 2024	EMA	Novo Nordisk A/S
June 24, 2024	PMDA	Novo Nordisk Pharma Ltd.

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

None

FDA Adverse Event Reporting System (Geriatric)

None

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

Source	Code	Description
ATC	A10AE07	ALIMENTARY TRACT AND METABOLISM DRUGS USED IN DIABETES INSULINS AND ANALOGUES Insulins and analogues for injection, long-acting
ATC	A10AE57	ALIMENTARY TRACT AND METABOLISM DRUGS USED IN DIABETES INSULINS AND ANALOGUES Insulins and analogues for injection, long-acting
MeSH PA	D007004	Hypoglycemic Agents
CHEBI has role	CHEBI:35526	hypoglycemic agent

Related Drugs by ATC class:

A10AE Insulins and analogues for injection, long-acting 9 drugs

insulin beefinsulin degludecinsulin detemirinsulin glargineinsulin humaninsulin porkliraglutidelixisenatidesemaglutide

Drug Use | Suggest Off label Use Form| |View source of the data|

Disease	Relation	SNOMED_ID	DOID
Diabetes mellitus type 2	indication	44054006	DOID:9352

🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

None

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

Target	Class	Pharos	UniProt	Action	Type	Activity value (-log[M])	Mechanism action	Bioact source	MoA source
Insulin receptor	Kinase	P06213	INSR_HUMAN					UNKNOWN	DRUG LABEL

External reference:

ID	Source
1188379-43-2	SECONDARY_CAS_RN
CHEMBL4594581	ChEMBL_ID
C000712207	MESH_SUPPLEMENTAL_RECORD_UI
DB16693	DRUGBANK_ID
C5434213	UMLSCUI
CHEBI:758054	CHEBI
11393	INN_ID
019763	NDDF
P7YU3ED05N	UNII
2740394	RXNORM
933375701000036106	SNOMEDCT_US
D12358	KEGG_DRUG

Pharmaceutical products:

Product	Category	Ingredients	NDC	Form	Quantity	Route	Marketing	Label
Awiqli	HUMAN PRESCRIPTION DRUG LABEL	1	0169-3105	INJECTION, SOLUTION	700 U	SUBCUTANEOUS	BLA	30 sections
Awiqli	HUMAN PRESCRIPTION DRUG LABEL	1	0169-3121	INJECTION, SOLUTION	700 U	SUBCUTANEOUS	BLA	30 sections
Awiqli	HUMAN PRESCRIPTION DRUG LABEL	1	0169-3170	INJECTION, SOLUTION	700 U	SUBCUTANEOUS	BLA	30 sections