insulin human 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | PK/Tox | Related Drugs | BioActivity |

Stem definitionDrug idCAS RN
5003 11061-68-0

Description:

MoleculeDescription

Synonyms:

  • insulin (human)
  • insulin
  • insulin regular human
  • insulin susp isophane recombinant human
  • insulin susp isophane semisynthetic purified human
  • insulin zinc susp extended recombinant human
  • insulin zinc susp recombinant human
  • insulin zinc susp semisynthetic purified human
  • insulin human base
  • insulin human isophane
  • insulin human
  • insulin recombinant human
  • insulin human (genetical recombination)
  • humulin
  • insulin recombinant purified human
Insulin (51 aa, ~6 kDa) is encoded by the human INS gene. This protein is involved in the direct regulation of glucose metabolism.
  • Molecular weight: 5807.63
  • Formula: C257H383N65O77S6
  • CLOGP:
  • LIPINSKI: None
  • HAC: None
  • HDO: None
  • TPSA: 2299.07
  • ALOGS:
  • ROTB: None

Drug dosage:

DoseUnitRoute
40 U P
40 U P
40 U P
40 U P
40 U P

ADMET properties:

None

Predicted pharmacokinetic/toxicological properties (PK-AZ):

None

Approvals:

DateAgencyCompanyOrphan
Oct. 28, 1982 FDA LILLY
Feb. 21, 1997 EMA Sanofi-Aventis Deutschland GmbH

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Blood glucose increased 1367.16 11.26 733 41829 94513 90491372
Hypoglycaemia 1177.53 11.26 599 41963 69249 90516636
Blood glucose decreased 462.56 11.26 224 42338 23205 90562680
Hyperglycaemia 406.43 11.26 269 42293 50701 90535184
Diabetic ketoacidosis 335.80 11.26 183 42379 24224 90561661
Diabetes mellitus inadequate control 328.19 11.26 165 42397 18519 90567366
Blood glucose fluctuation 253.77 11.26 94 42468 4989 90580896
Toothache 247.16 11.26 145 42417 22085 90563800
Glycosylated haemoglobin increased 243.08 11.26 127 42435 15435 90570450
Pharyngitis 238.36 11.26 141 42421 21806 90564079
Multi-organ disorder 234.66 11.26 72 42490 2128 90583757
Cardiac failure congestive 208.08 11.26 244 42318 98450 90487435
Eye haemorrhage 184.93 11.26 92 42470 10088 90575797
Ketoacidosis 149.43 11.26 66 42496 5529 90580356
Hypoglycaemic coma 148.17 11.26 55 42507 2935 90582950
Diabetic retinopathy 142.38 11.26 52 42510 2650 90583235
Synovitis 140.30 11.26 3 42559 329749 90256136
Systemic lupus erythematosus 134.82 11.26 9 42553 361887 90223998
Glossodynia 132.85 11.26 4 42558 321775 90264110
Blood glucose abnormal 130.04 11.26 71 42491 9421 90576464
Contraindicated product administered 125.27 11.26 6 42556 320133 90265752
Treatment failure 124.66 11.26 4 42558 303924 90281961
Malnutrition 115.10 11.26 84 42478 18474 90567411
Drug intolerance 112.82 11.26 35 42527 447556 90138329
Pericarditis 112.82 11.26 3 42559 270148 90315737
Hyperkalaemia 108.57 11.26 143 42419 64821 90521064
Joint swelling 107.56 11.26 51 42511 503249 90082636
Infusion related reaction 106.10 11.26 32 42530 416748 90169137
Acute kidney injury 105.92 11.26 361 42201 320026 90265859
Alopecia 103.01 11.26 52 42510 495019 90090866
Thyroid disorder 102.45 11.26 77 42485 17708 90568177
Renal failure 101.09 11.26 203 42359 130804 90455081
Off label use 97.22 11.26 236 42326 1102016 89483869
Insulin resistance 94.89 11.26 31 42531 1127 90584758
Anti-insulin antibody positive 92.62 11.26 19 42543 95 90585790
Lactic acidosis 92.03 11.26 116 42446 50347 90535538
Product prescribing error 88.84 11.26 89 42473 30056 90555829
Arthropathy 86.41 11.26 32 42530 366210 90219675
Product complaint 85.75 11.26 62 42500 13438 90572447
Abdominal discomfort 85.40 11.26 60 42502 477268 90108617
Pulmonary oedema 84.77 11.26 124 42438 61956 90523929
Hepatic enzyme increased 84.30 11.26 32 42530 360704 90225181
Pericardial effusion 84.18 11.26 95 42467 36738 90549147
Hypoglycaemic unconsciousness 84.10 11.26 26 42536 788 90585097
Foetal exposure during pregnancy 83.52 11.26 102 42460 42873 90543012
Myocardial infarction 82.69 11.26 165 42397 105807 90480078
Folliculitis 82.68 11.26 3 42559 204350 90381535
Discomfort 81.73 11.26 15 42547 274320 90311565
Dehydration 81.56 11.26 238 42324 194209 90391676
Duodenal ulcer perforation 80.93 11.26 6 42556 221282 90364603
Helicobacter infection 80.60 11.26 7 42555 226843 90359042
Pain 80.36 11.26 223 42339 996118 89589767
Incorrect dose administered 77.97 11.26 136 42426 78794 90507091
Anti-insulin antibody increased 75.22 11.26 14 42548 37 90585848
Irritable bowel syndrome 74.80 11.26 6 42556 207442 90378443
Musculoskeletal stiffness 73.22 11.26 24 42538 296508 90289377
Rheumatoid arthritis 71.11 11.26 41 42521 362573 90223312
Coronary artery disease 70.58 11.26 83 42479 33540 90552345
Sepsis 70.57 11.26 215 42347 179599 90406286
Diabetic neuropathy 70.48 11.26 37 42525 4537 90581348
Blindness 70.25 11.26 74 42488 26494 90559391
Product use issue 68.04 11.26 35 42527 329884 90256001
Therapeutic product effect decreased 64.20 11.26 25 42537 277546 90308339
Wrong product administered 62.36 11.26 41 42521 7624 90578261
Psoriatic arthropathy 60.89 11.26 16 42546 228319 90357566
Cerebrovascular accident 58.43 11.26 158 42404 123375 90462510
Exposure during pregnancy 58.24 11.26 244 42318 238166 90347719
Swelling 57.81 11.26 67 42495 418991 90166894
Insulin C-peptide decreased 55.23 11.26 11 42551 46 90585839
Therapeutic product effect incomplete 54.81 11.26 12 42550 193884 90392001
Fatigue 54.48 11.26 319 42243 1153704 89432181
Fibromyalgia 53.97 11.26 15 42547 206254 90379631
Product use in unapproved indication 52.89 11.26 48 42514 336188 90249697
Ill-defined disorder 51.15 11.26 12 42550 184879 90401006
Rash 51.02 11.26 197 42365 795903 89789982
Conjoined twins 50.86 11.26 16 42546 514 90585371
Hypoglycaemic seizure 50.00 11.26 16 42546 544 90585341
Cardiac arrest 49.41 11.26 134 42428 104801 90481084
Blood insulin increased 48.52 11.26 12 42550 154 90585731
Retinopathy 47.21 11.26 26 42536 3508 90582377
Urinary tract infection 46.89 11.26 274 42288 305358 90280527
Nasopharyngitis 46.17 11.26 75 42487 407029 90178856
Hypersensitivity 45.95 11.26 90 42472 454587 90131298
Increased insulin requirement 44.82 11.26 10 42552 79 90585806
Chronic kidney disease 43.84 11.26 82 42480 50109 90535776
Wrong technique in product usage process 43.79 11.26 101 42461 71470 90514415
Intentional product use issue 43.24 11.26 24 42538 216868 90369017
Inflammation 43.11 11.26 15 42547 178577 90407308
Anti-insulin antibody 41.52 11.26 8 42554 27 90585858
Neuropathy peripheral 41.41 11.26 150 42412 136820 90449065
Diabetes mellitus 41.30 11.26 93 42469 64782 90521103
Gastrointestinal disorder 41.13 11.26 36 42526 256651 90329234
Sinusitis 40.99 11.26 61 42501 343027 90242858
Completed suicide 40.95 11.26 9 42553 145049 90440836
Erdheim-Chester disease 40.93 11.26 9 42553 66 90585819
Gait inability 40.62 11.26 156 42406 146300 90439585
Stevens-Johnson syndrome 40.56 11.26 59 42503 29317 90556568
Renal impairment 40.35 11.26 125 42437 105296 90480589
Premature baby 40.03 11.26 54 42508 25023 90560862
Stomatitis 39.96 11.26 42 42520 274656 90311229
Bursitis 39.62 11.26 7 42555 131647 90454238
Diabetic metabolic decompensation 39.47 11.26 19 42543 1938 90583947
Drug hypersensitivity 39.31 11.26 101 42461 463508 90122377
Mobility decreased 39.17 11.26 36 42526 250698 90335187
Cardiac failure 38.41 11.26 126 42436 109370 90476515
Wheezing 37.41 11.26 34 42528 238046 90347839
Joint range of motion decreased 37.12 11.26 9 42553 135634 90450251
Blood creatinine increased 36.76 11.26 118 42444 101268 90484617
Impaired healing 36.14 11.26 34 42528 234165 90351720
Anaemia 35.98 11.26 286 42276 352516 90233369
Peripheral swelling 35.78 11.26 89 42473 413017 90172868
Migraine 35.24 11.26 23 42539 190369 90395516
Sleep disorder 35.21 11.26 25 42537 198005 90387880
Insulinoma 35.15 11.26 9 42553 134 90585751
Fall 35.07 11.26 363 42199 481447 90104438
Polyhydramnios 35.02 11.26 19 42543 2489 90583396
Central nervous system injury 34.55 11.26 9 42553 144 90585741
Maternal exposure during pregnancy 33.56 11.26 286 42276 359777 90226108
Paraesthesia 33.44 11.26 41 42521 250285 90335600
Blood lactic acid decreased 32.88 11.26 11 42551 431 90585454
Type 1 diabetes mellitus 32.63 11.26 23 42539 4789 90581096
Diabetic nephropathy 32.46 11.26 16 42546 1718 90584167
Product dispensing error 32.12 11.26 34 42528 12239 90573646
Blood creatine phosphokinase increased 31.49 11.26 57 42505 33966 90551919
Weight decreased 31.41 11.26 294 42268 379616 90206269
Liver injury 31.03 11.26 21 42541 170546 90415339
Visual acuity reduced 30.85 11.26 46 42516 23364 90562521
Toxic epidermal necrolysis 30.75 11.26 55 42507 32473 90553412
Wound 29.70 11.26 61 42501 302919 90282966
Congenital multiplex arthrogryposis 29.63 11.26 7 42555 73 90585812
Atrial fibrillation 28.97 11.26 132 42430 133479 90452406
Loss of consciousness 28.53 11.26 136 42426 140102 90445783
Type 2 diabetes mellitus 28.53 11.26 32 42530 203212 90382673
Cellulitis 28.43 11.26 101 42461 91236 90494649
Drug ineffective 28.02 11.26 470 42092 1383828 89202057
Drug abuse 28.02 11.26 3 42559 82344 90503541
Hepatic function abnormal 27.96 11.26 65 42497 46223 90539662
Blister 27.93 11.26 48 42514 254950 90330935
Night sweats 27.52 11.26 13 42549 128753 90457132
Euglycaemic diabetic ketoacidosis 27.45 11.26 23 42539 6178 90579707
Arrhythmia 27.29 11.26 61 42501 42271 90543614
Expired product administered 27.24 11.26 24 42538 6898 90578987
Splenic injury 27.12 11.26 8 42554 206 90585679
Bradycardia neonatal 26.34 11.26 12 42550 1081 90584804
Thirst 25.87 11.26 35 42527 16260 90569625
Dry mouth 25.81 11.26 29 42533 184030 90401855
Urosepsis 25.55 11.26 40 42522 21192 90564693
Foetal hypokinesia 25.55 11.26 10 42552 617 90585268
Cerebral infarction 25.18 11.26 45 42517 26551 90559334
Hypercholesterolaemia 25.17 11.26 8 42554 100884 90485001
Bradyarrhythmia 24.61 11.26 15 42547 2446 90583439
Acute myocardial infarction 24.45 11.26 52 42510 34838 90551047
Pulmonary fibrosis 24.32 11.26 10 42552 107493 90478392
Insomnia 24.31 11.26 78 42484 333396 90252489
Myalgia 24.28 11.26 153 42409 174972 90410913
Peripheral venous disease 24.10 11.26 5 42557 83916 90501969
Vitamin B1 increased 24.00 11.26 7 42555 173 90585712
Tachyarrhythmia 23.82 11.26 20 42542 5386 90580499
Accidental underdose 23.25 11.26 11 42551 1080 90584805
Hypochromasia 23.16 11.26 8 42554 346 90585539
Hypoglycaemia neonatal 22.95 11.26 11 42551 1111 90584774
Medical device site abscess 22.90 11.26 7 42555 204 90585681
Lung disorder 22.83 11.26 22 42540 149861 90436024
Drug-device interaction 22.11 11.26 6 42556 113 90585772
Diabetic foot 21.79 11.26 12 42550 1619 90584266
Hypoglycaemia unawareness 21.77 11.26 6 42556 120 90585765
Urticaria 21.53 11.26 75 42487 312659 90273226
Sprue-like enteropathy 21.51 11.26 10 42552 943 90584942
Urine output decreased 21.44 11.26 28 42534 12575 90573310
Glycosylated haemoglobin abnormal 21.18 11.26 7 42555 264 90585621
Necrotising colitis 21.12 11.26 11 42551 1327 90584558
Disseminated intravascular coagulation 21.11 11.26 37 42525 21501 90564384
Dyspepsia 21.06 11.26 38 42524 198122 90387763
Hyperglycaemic hyperosmolar nonketotic syndrome 20.88 11.26 11 42551 1358 90584527
Haemodialysis 20.73 11.26 23 42539 8724 90577161
Diabetic coma 20.61 11.26 9 42553 733 90585152
Hypokalaemia 20.36 11.26 118 42444 130998 90454887
Metabolic acidosis 20.36 11.26 65 42497 55611 90530274
Pneumonia aspiration 19.98 11.26 53 42509 40887 90544998
Cardiac output increased 19.91 11.26 8 42554 529 90585356
Vitamin B1 decreased 19.90 11.26 8 42554 530 90585355
Red blood cell sedimentation rate increased 19.82 11.26 7 42555 82588 90503297
Foreign body in gastrointestinal tract 19.81 11.26 5 42557 70 90585815
Bradycardia 19.81 11.26 85 42477 83762 90502123
Blood urea increased 19.80 11.26 44 42518 30369 90555516
Acidosis 19.68 11.26 27 42535 12709 90573176
Rabbit syndrome 19.62 11.26 7 42555 333 90585552
Hypoglycaemic encephalopathy 19.60 11.26 7 42555 334 90585551
Treatment noncompliance 19.47 11.26 61 42501 51666 90534219
Blood cholesterol increased 19.44 11.26 43 42519 207969 90377916
Renal injury 19.39 11.26 24 42538 10219 90575666
Autoimmune disorder 19.30 11.26 6 42556 76738 90509147
Hyperchloraemia 19.06 11.26 9 42553 879 90585006
Product storage error 18.84 11.26 34 42528 20207 90565678
Grip strength decreased 18.79 11.26 10 42552 92566 90493319
Renal dysplasia 18.79 11.26 7 42555 377 90585508
Premature delivery 18.74 11.26 50 42512 38712 90547173
Hypervolaemia 18.70 11.26 45 42517 32712 90553173
Loss of personal independence in daily activities 18.48 11.26 22 42540 136083 90449802
Atrial septal defect 18.40 11.26 21 42541 8213 90577672
Medical device site cellulitis 18.32 11.26 6 42556 220 90585665
Multiple organ dysfunction syndrome 18.29 11.26 72 42490 68264 90517621
Congenital bladder anomaly 18.14 11.26 6 42556 227 90585658
Type III immune complex mediated reaction 18.13 11.26 7 42555 416 90585469
Nail disorder 18.07 11.26 3 42559 59064 90526821
Device material issue 18.02 11.26 7 42555 423 90585462
Respiratory failure 18.02 11.26 106 42456 118312 90467573
Pre-eclampsia 17.95 11.26 24 42538 11024 90574861
Congenital hydronephrosis 17.93 11.26 7 42555 429 90585456
Medication error 17.87 11.26 83 42479 84569 90501316
Respiratory disorder neonatal 17.87 11.26 10 42552 1391 90584494
Epidermolysis 17.77 11.26 8 42554 701 90585184
Blood pressure decreased 17.75 11.26 76 42486 74819 90511066
Dialysis 17.48 11.26 24 42538 11305 90574580
Oedema peripheral 17.17 11.26 191 42371 257724 90328161
Arthralgia 17.11 11.26 260 42302 778262 89807623
Mental status changes 17.10 11.26 53 42509 44626 90541259
Neck pain 17.04 11.26 17 42545 113946 90471939
Small for dates baby 17.04 11.26 16 42546 4991 90580894
Taste disorder 17.00 11.26 4 42558 61542 90524343
Paraneoplastic rash 16.98 11.26 5 42557 128 90585757
Anisocytosis 16.83 11.26 8 42554 793 90585092
Injury 16.69 11.26 43 42519 197306 90388579
Ear infection 16.59 11.26 6 42556 69769 90516116
Gastroenteritis 16.52 11.26 40 42522 29189 90556696
Agitation neonatal 16.28 11.26 7 42555 549 90585336
Bicuspid aortic valve 16.25 11.26 5 42557 149 90585736
Chest pain 16.24 11.26 225 42337 319420 90266465
Diabetic ketosis 16.22 11.26 7 42555 554 90585331
Hypophagia 16.02 11.26 45 42517 35892 90549993
Blood potassium increased 15.80 11.26 32 42530 20717 90565168
Insulin autoimmune syndrome 15.77 11.26 5 42557 165 90585720
Hydrops foetalis 15.63 11.26 7 42555 606 90585279
Angina unstable 15.60 11.26 18 42544 7125 90578760
Renal disorder 15.52 11.26 46 42516 37813 90548072
Contusion 15.49 11.26 63 42499 251153 90334732
Gastric ulcer perforation 15.45 11.26 9 42553 1351 90584534
Macrosomia 15.41 11.26 4 42558 63 90585822
Macular oedema 15.40 11.26 15 42547 4894 90580991
Congenital aortic valve stenosis 15.30 11.26 4 42558 65 90585820
Decubitus ulcer 15.26 11.26 23 42539 11790 90574095
Platelet count decreased 15.02 11.26 113 42449 136856 90449029
Adverse event 14.87 11.26 20 42542 117398 90468487
Laryngitis 14.62 11.26 3 42559 50750 90535135
Pulmonary valve stenosis 14.58 11.26 6 42556 422 90585463
Septic shock 14.57 11.26 78 42484 84082 90501803
Altered state of consciousness 14.56 11.26 40 42522 31492 90554393
Infection 14.48 11.26 105 42457 361989 90223896
Product monitoring error 14.47 11.26 14 42548 4530 90581355
Intestinal malrotation 14.34 11.26 6 42556 440 90585445
Papillary thyroid cancer 14.30 11.26 11 42551 2616 90583269
Syncope 14.30 11.26 109 42453 132554 90453331
Procalcitonin increased 14.29 11.26 9 42553 1555 90584330
Toe amputation 14.29 11.26 10 42552 2059 90583826
Hypercreatininaemia 14.25 11.26 7 42555 746 90585139
Hyperaemia 14.25 11.26 11 42551 2631 90583254
Knee arthroplasty 14.13 11.26 11 42551 83171 90502714
Urachal abnormality 14.05 11.26 5 42557 236 90585649
Hepatic encephalopathy 13.94 11.26 24 42538 13748 90572137
Fat tissue decreased 13.87 11.26 4 42558 95 90585790
Gastrointestinal haemorrhage 13.86 11.26 81 42481 90167 90495718
Lupus-like syndrome 13.84 11.26 3 42559 48843 90537042
Therapy non-responder 13.83 11.26 27 42535 136677 90449208
Persistent cloaca 13.80 11.26 5 42557 249 90585636
Joint stiffness 13.67 11.26 10 42552 78032 90507853
Transient ischaemic attack 13.65 11.26 48 42514 43128 90542757
Exostosis 13.64 11.26 4 42558 53130 90532755
Lip erosion 13.56 11.26 8 42554 1230 90584655
Urogenital haemorrhage 13.55 11.26 5 42557 262 90585623
Cold sweat 13.55 11.26 24 42538 14057 90571828
Intercepted product selection error 13.53 11.26 3 42559 23 90585862
Muscle atrophy 13.27 11.26 18 42544 8383 90577502
Shock hypoglycaemic 13.17 11.26 4 42558 114 90585771
Tachycardia 12.99 11.26 122 42440 157551 90428334
Pulmonary artery stenosis 12.94 11.26 5 42557 298 90585587
Circulatory collapse 12.93 11.26 33 42529 24871 90561014
Neonatal respiratory distress syndrome 12.70 11.26 11 42551 3090 90582795
Congenital mitral valve incompetence 12.64 11.26 3 42559 32 90585853
Diabetic vascular disorder 12.64 11.26 3 42559 32 90585853
Unresponsive to stimuli 12.59 11.26 43 42519 38078 90547807
Diabetic complication 12.56 11.26 7 42555 966 90584919
Hyperhidrosis 12.53 11.26 108 42454 136197 90449688
Hepatosplenic candidiasis 12.50 11.26 5 42557 327 90585558
Memory impairment 12.45 11.26 49 42513 197195 90388690
Metastases to pancreas 12.39 11.26 5 42557 334 90585551
Liver function test increased 12.30 11.26 13 42549 84842 90501043
Glycosylated haemoglobin decreased 12.19 11.26 6 42556 643 90585242
Diabetic hyperglycaemic coma 12.17 11.26 3 42559 38 90585847
Blood ketone body increased 12.09 11.26 5 42557 356 90585529
Protein deficiency 12.08 11.26 5 42557 357 90585528
Selective eating disorder 12.07 11.26 9 42553 2044 90583841
Prescribed overdose 11.99 11.26 17 42545 97608 90488277
Bipolar I disorder 11.96 11.26 9 42553 2073 90583812
Hypertensive nephropathy 11.94 11.26 6 42556 672 90585213
Cardiomegaly 11.89 11.26 27 42535 18898 90566987
Gamma-glutamyltransferase increased 11.83 11.26 42 42520 37910 90547975
Shock 11.82 11.26 35 42527 28743 90557142
Musculoskeletal pain 11.82 11.26 41 42521 171210 90414675
Hyperlactacidaemia 11.80 11.26 12 42550 4124 90581761
Diabetic ulcer 11.74 11.26 4 42558 166 90585719
Hyperphagia 11.55 11.26 10 42552 2808 90583077
Diaphragmalgia 11.53 11.26 4 42558 175 90585710
Blindness unilateral 11.36 11.26 16 42546 7720 90578165
Cataract 11.26 11.26 65 42497 72027 90513858

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Hypoglycaemia 900.62 11.27 602 38334 59252 42523147
Blood glucose increased 832.25 11.27 622 38314 73077 42509322
Blood glucose decreased 322.43 11.27 186 38750 14033 42568366
Hyperglycaemia 253.49 11.27 258 38678 45601 42536798
Diabetes mellitus inadequate control 205.30 11.27 144 38792 15246 42567153
Glycosylated haemoglobin increased 165.59 11.27 118 38818 12806 42569593
Diabetic ketoacidosis 136.73 11.27 133 38803 22234 42560165
Anti-insulin antibody positive 130.42 11.27 31 38905 156 42582243
Blood glucose fluctuation 122.96 11.27 67 38869 4520 42577879
Off label use 104.97 11.27 272 38664 638063 41944336
Hypoglycaemic unconsciousness 82.78 11.27 30 38906 754 42581645
Blood glucose abnormal 82.60 11.27 61 38875 6992 42575407
Diabetic retinopathy 69.16 11.27 35 38901 2028 42580371
Hypoglycaemic coma 67.83 11.27 38 38898 2706 42579693
Toxicity to various agents 65.12 11.27 68 38868 229068 42353331
Incorrect dose administered 61.54 11.27 144 38792 52830 42529569
Drug abuse 61.01 11.27 11 38925 104760 42477639
Anti-insulin antibody increased 59.82 11.27 14 38922 65 42582334
Drug ineffective 57.90 11.27 339 38597 629858 41952541
Completed suicide 54.31 11.27 11 38925 96454 42485945
Clear cell renal cell carcinoma 52.72 11.27 25 38911 1256 42581143
Anti-insulin antibody 52.67 11.27 11 38925 26 42582373
Alveolar lung disease 49.98 11.27 18 38918 444 42581955
Pulmonary interstitial emphysema syndrome 46.51 11.27 18 38918 545 42581854
Diabetic neuropathy 44.07 11.27 35 38901 4467 42577932
Insulin resistance 43.34 11.27 19 38917 794 42581605
Hypoglycaemia unawareness 41.34 11.27 12 38924 144 42582255
Drug interaction 41.17 11.27 117 38819 266882 42315517
Cardiac failure congestive 41.10 11.27 171 38765 85431 42496968
Hypoglycaemic seizure 41.05 11.27 15 38921 386 42582013
Product use in unapproved indication 40.78 11.27 66 38870 184390 42398009
Hypoglycaemic encephalopathy 40.37 11.27 14 38922 308 42582091
Diabetic metabolic decompensation 38.54 11.27 24 38912 2078 42580321
Product prescribing error 37.12 11.27 77 38859 26035 42556364
Toxic epidermal necrolysis 37.00 11.27 78 38858 26672 42555727
Blindness 36.81 11.27 62 38874 17916 42564483
Platelet distribution width increased 36.61 11.27 11 38925 150 42582249
Product complaint 33.65 11.27 34 38902 5943 42576456
Toe amputation 33.55 11.27 25 38911 2904 42579495
Blood urea increased 32.60 11.27 84 38852 32709 42549690
Wrong product administered 32.49 11.27 34 38902 6192 42576207
Finnegan score increased 31.60 11.27 7 38929 24 42582375
Cardiac failure 30.99 11.27 185 38751 106671 42475728
Diffuse alveolar damage 29.41 11.27 22 38914 2570 42579829
Acute myocardial infarction 29.33 11.27 118 38818 58047 42524352
Diabetic nephropathy 29.12 11.27 21 38915 2320 42580079
Myocardial infarction 28.80 11.27 203 38733 123806 42458593
Product dispensing error 28.43 11.27 35 38901 7604 42574795
Dehiscence 27.79 11.27 13 38923 633 42581766
Oedema peripheral 26.66 11.27 214 38722 135862 42446537
Renal failure 26 11.27 222 38714 143504 42438895
Diabetes mellitus 25.73 11.27 116 38820 59971 42522428
Infant irritability 25.64 11.27 7 38929 66 42582333
Neutropenia 25.43 11.27 95 38841 199336 42383063
Agitation neonatal 25.42 11.27 16 38920 1412 42580987
Disease progression 25.13 11.27 59 38877 143597 42438802
Meningomyelocele 25.03 11.27 9 38927 221 42582178
Peripheral arterial occlusive disease 24.91 11.27 31 38905 6807 42575592
Angina pectoris 24.59 11.27 76 38860 32820 42549579
Joint swelling 24.46 11.27 16 38920 68006 42514393
Diabetic foot 24.07 11.27 21 38915 3052 42579347
Wrong technique in product usage process 23.53 11.27 89 38847 42546 42539853
Treatment failure 23.53 11.27 14 38922 62610 42519789
Congenital multiplex arthrogryposis 23.52 11.27 9 38927 264 42582135
General physical health deterioration 23.47 11.27 226 38710 151020 42431379
Oral mucosal eruption 23.29 11.27 10 38926 397 42582002
Neonatal hypoxia 23.26 11.27 11 38925 549 42581850
Gangrene 23.26 11.27 26 38910 5100 42577299
Intra-abdominal haemorrhage 22.92 11.27 20 38916 2908 42579491
Renal impairment 22.49 11.27 175 38761 110053 42472346
Glycosylated haemoglobin decreased 22.39 11.27 10 38926 437 42581962
Hypoaldosteronism 22.08 11.27 9 38927 313 42582086
Lymphangitis 21.67 11.27 11 38925 641 42581758
Drug ineffective for unapproved indication 20.89 11.27 8 38928 46155 42536244
Blood urea abnormal 20.88 11.27 13 38923 1125 42581274
Sepsis 20.57 11.27 275 38661 199059 42383340
Acute kidney injury 20.53 11.27 459 38477 366878 42215521
Blood creatinine increased 20.46 11.27 171 38765 109832 42472567
Floppy infant 20.36 11.27 7 38929 150 42582249
Hyperlipidaemia 20.24 11.27 54 38882 21462 42560937
Mucosal inflammation 20.06 11.27 10 38926 49364 42533035
Diabetic complication 20.02 11.27 11 38925 754 42581645
Infusion site induration 19.84 11.27 9 38927 408 42581991
Bronchopneumopathy 19.60 11.27 10 38926 589 42581810
Blood sodium abnormal 19.51 11.27 10 38926 595 42581804
Eosinophilic pneumonia 19.22 11.27 23 38913 4851 42577548
Diabetic hyperglycaemic coma 19.05 11.27 5 38931 40 42582359
Lymphoproliferative disorder 18.96 11.27 19 38917 3288 42579111
Arthralgia 18.91 11.27 110 38826 205128 42377271
Cutaneous amyloidosis 18.73 11.27 5 38931 43 42582356
Accidental underdose 18.53 11.27 10 38926 661 42581738
Renal cell carcinoma 18.50 11.27 24 38912 5493 42576906
Hepatic encephalopathy 18.32 11.27 44 38892 16398 42566001
Coronary artery disease 18.20 11.27 97 38839 53623 42528776
Selective eating disorder 17.88 11.27 14 38922 1750 42580649
Sleep disorder 17.72 11.27 11 38925 48084 42534315
Hypokalaemia 17.57 11.27 119 38817 71602 42510797
Diabetic coma 17.28 11.27 11 38925 990 42581409
Product storage error 17.20 11.27 34 38902 11106 42571293
Dementia 17.19 11.27 43 38893 16437 42565962
Type 1 diabetes mellitus 17.06 11.27 23 38913 5464 42576935
Therapeutic product effect incomplete 16.99 11.27 24 38912 70915 42511484
Visual impairment 16.81 11.27 81 38855 43032 42539367
Intentional product use issue 16.52 11.27 25 38911 71808 42510591
Chronic kidney disease 16.48 11.27 86 38850 47155 42535244
Agitated depression 16.47 11.27 7 38929 271 42582128
Respiratory failure 16.34 11.27 184 38752 127948 42454451
Blood creatinine abnormal 16.17 11.27 17 38919 3112 42579287
Microalbuminuria 16.08 11.27 10 38926 864 42581535
Anti factor V antibody 15.63 11.27 7 38929 308 42582091
Full blood count abnormal 15.62 11.27 4 38932 29872 42552527
Visual acuity reduced 15.47 11.27 43 38893 17507 42564892
Somogyi phenomenon 15.46 11.27 3 38933 4 42582395
Hydrocholecystis 15.23 11.27 8 38928 501 42581898
Urethral cancer 15.15 11.27 5 38931 94 42582305
Loss of personal independence in daily activities 15.02 11.27 14 38922 49802 42532597
Meningocele 14.92 11.27 4 38932 35 42582364
Death 14.84 11.27 323 38613 470862 42111537
Dyspnoea 14.82 11.27 518 38418 442103 42140296
Platelet count decreased 14.62 11.27 192 38744 138389 42444010
Ketoacidosis 14.50 11.27 21 38915 5331 42577068
Arrhythmia 14.48 11.27 74 38862 40243 42542156
Product monitoring error 14.46 11.27 19 38917 4404 42577995
Foetal exposure during pregnancy 14.40 11.27 83 38853 47228 42535171
Electrocardiogram T wave amplitude decreased 14.34 11.27 7 38929 375 42582024
Febrile neutropenia 14.33 11.27 105 38831 185598 42396801
Internal haemorrhage 14.29 11.27 21 38915 5400 42576999
Product administration error 14.29 11.27 43 38893 18300 42564099
Hepatic function abnormal 14.12 11.27 88 38848 51479 42530920
Rheumatoid arthritis 13.92 11.27 11 38925 42429 42539970
Disseminated intravascular coagulation 13.88 11.27 52 38884 24742 42557657
Spermatic cord disorder 13.85 11.27 3 38933 9 42582390
Product use issue 13.83 11.27 31 38905 76720 42505679
Foot amputation 13.76 11.27 9 38927 848 42581551
Streptococcal infection 13.70 11.27 22 38914 6110 42576289
Necrosis 13.70 11.27 23 38913 6628 42575771
Post thrombotic syndrome 13.67 11.27 5 38931 129 42582270
Pneumonia 13.62 11.27 492 38444 421657 42160742
Diabetic gangrene 13.59 11.27 6 38930 255 42582144
Blood potassium abnormal 13.58 11.27 12 38924 1774 42580625
Pancreatic carcinoma 13.47 11.27 28 38908 9478 42572921
Mean platelet volume increased 13.47 11.27 8 38928 636 42581763
Urosepsis 13.43 11.27 37 38899 14983 42567416
Cold sweat 13.36 11.27 31 38905 11299 42571100
Ketosis 13.32 11.27 9 38927 896 42581503
Hydrops foetalis 13.32 11.27 9 38927 896 42581503
Hepatic cytolysis 13.28 11.27 4 38932 26840 42555559
Impaired insulin secretion 13.18 11.27 3 38933 12 42582387
Leg amputation 13.11 11.27 14 38922 2609 42579790
Hyperglycaemic hyperosmolar nonketotic syndrome 12.56 11.27 11 38925 1607 42580792
Serotonin syndrome 12.51 11.27 4 38932 25841 42556558
Sinusitis 12.35 11.27 15 38921 47277 42535122
Pulmonary artery stenosis 12.33 11.27 6 38930 319 42582080
Electrocardiogram ST segment abnormal 12.21 11.27 8 38928 756 42581643
Pelvic abscess 12.15 11.27 9 38927 1036 42581363
Thyroid gland abscess 12.13 11.27 4 38932 75 42582324
Systemic infection 12.08 11.27 19 38917 5186 42577213
Transferrin saturation decreased 12.06 11.27 7 38929 533 42581866
Coombs negative haemolytic anaemia 12.05 11.27 5 38931 182 42582217
Hypochromic anaemia 11.88 11.27 9 38927 1071 42581328
Glomerular filtration rate increased 11.75 11.27 8 38928 806 42581593
Neuropathic arthropathy 11.73 11.27 5 38931 195 42582204
Shock hypoglycaemic 11.62 11.27 4 38932 86 42582313
Pulmonary embolism 11.60 11.27 63 38873 119549 42462850
Peripheral ischaemia 11.50 11.27 21 38915 6464 42575935
Congenital pulmonary hypertension 11.45 11.27 4 38932 90 42582309
Ischaemic cardiomyopathy 11.42 11.27 21 38915 6501 42575898
Wound 11.39 11.27 38 38898 17079 42565320
Drug withdrawal syndrome neonatal 11.36 11.27 17 38919 4444 42577955
Blood potassium increased 11.32 11.27 40 38896 18496 42563903

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Hypoglycaemia 1745.17 10.54 1003 65576 115101 110407619
Blood glucose increased 1193.43 10.54 828 65751 131668 110391052
Hyperglycaemia 615.41 10.54 466 66113 84624 110438096
Blood glucose decreased 453.38 10.54 259 66320 29229 110493491
Diabetes mellitus inadequate control 398.36 10.54 239 66340 29536 110493184
Diabetic ketoacidosis 366.64 10.54 258 66321 41800 110480920
Glycosylated haemoglobin increased 278.69 10.54 175 66404 23444 110499276
Blood glucose fluctuation 262.26 10.54 116 66463 7582 110515138
Anti-insulin antibody positive 210.43 10.54 46 66533 245 110522475
Cardiac failure congestive 190.68 10.54 333 66246 150667 110372053
Multi-organ disorder 190.39 10.54 73 66506 3308 110519412
Hypoglycaemic coma 187.27 10.54 83 66496 5450 110517270
Eye haemorrhage 156.12 10.54 94 66485 11680 110511040
Off label use 153.52 10.54 433 66146 1499752 109022968
Synovitis 150.19 10.54 3 66576 274089 110248631
Diabetic retinopathy 148.72 10.54 62 66517 3502 110519218
Acute kidney injury 145.33 10.54 760 65819 634670 109888050
Systemic lupus erythematosus 124.69 10.54 7 66572 254331 110268389
Product prescribing error 122.75 10.54 153 66426 51178 110471542
Joint swelling 118.95 10.54 59 66520 442786 110079934
Renal failure 118.45 10.54 352 66227 226222 110296498
Glossodynia 115.75 10.54 4 66575 222000 110300720
Treatment failure 111.24 10.54 17 66562 277217 110245503
Pericarditis 110.67 10.54 5 66574 219109 110303611
Anti-insulin antibody increased 110.21 10.54 23 66556 94 110522626
Drug ineffective 107.16 10.54 512 66067 1520028 109002692
Alopecia 105.09 10.54 44 66535 364709 110158011
Infusion related reaction 103.53 10.54 50 66529 381112 110141608
Myocardial infarction 102.84 10.54 301 66278 191782 110330938
Ketoacidosis 102.37 10.54 68 66511 10019 110512701
Sepsis 98.31 10.54 424 66155 326922 110195798
Drug intolerance 97.86 10.54 62 66517 406450 110116270
Completed suicide 96.93 10.54 15 66564 242366 110280354
Hyperkalaemia 95.06 10.54 235 66344 135561 110387159
Blood glucose abnormal 93.83 10.54 71 66508 12845 110509875
Product complaint 93.18 10.54 73 66506 13899 110508821
Malnutrition 91.75 10.54 97 66482 27182 110495538
Diabetic neuropathy 90.53 10.54 55 66524 6944 110515776
Anti-insulin antibody 90.07 10.54 18 66561 56 110522664
Hypoglycaemic unconsciousness 89.52 10.54 32 66547 1188 110521532
Helicobacter infection 89.15 10.54 5 66574 181872 110340848
Insulin resistance 88.99 10.54 35 66544 1699 110521021
Thyroid disorder 86.76 10.54 76 66503 16893 110505827
Rheumatoid arthritis 86.52 10.54 36 66543 299577 110223143
Arthropathy 85.55 10.54 33 66546 287489 110235231
Toothache 83.17 10.54 86 66493 23489 110499231
Diabetic metabolic decompensation 81.61 10.54 42 66537 3847 110518873
Duodenal ulcer perforation 80.97 10.54 7 66572 177693 110345027
Pharyngitis 78.70 10.54 86 66493 25012 110497708
Toxic epidermal necrolysis 75.33 10.54 128 66451 56599 110466121
Abdominal discomfort 74.84 10.54 76 66503 393782 110128938
Blood creatinine increased 72.82 10.54 259 66320 182630 110340090
Coronary artery disease 72.74 10.54 144 66435 71546 110451174
Musculoskeletal stiffness 72.53 10.54 39 66540 279783 110242937
Pain 72.13 10.54 313 66266 954642 109568078
Muscle injury 71.80 10.54 3 66576 140804 110381916
Renal impairment 70.90 10.54 262 66317 188183 110334537
Drug abuse 70.87 10.54 11 66568 177400 110345320
Product use in unapproved indication 70.47 10.54 100 66479 447277 110075443
Fibromyalgia 69.65 10.54 10 66569 170899 110351821
Acute myocardial infarction 69.54 10.54 155 66424 83622 110439098
Hypoglycaemic seizure 69.46 10.54 25 66554 947 110521773
Pulmonary oedema 69.17 10.54 173 66406 100486 110422234
Cardiac failure 69.04 10.54 259 66320 187367 110335353
Psoriatic arthropathy 68.53 10.54 17 66562 196744 110325976
Irritable bowel syndrome 68.36 10.54 9 66570 164206 110358514
Folliculitis 67.88 10.54 10 66569 167643 110355077
Therapeutic product effect decreased 64.87 10.54 33 66546 244283 110278437
Dehydration 64.14 10.54 335 66244 279176 110243544
Pericardial effusion 63.03 10.54 119 66460 57098 110465622
Product use issue 61.68 10.54 58 66521 311637 110211083
Therapeutic product effect incomplete 61.28 10.54 29 66550 223776 110298944
Intentional product use issue 60.74 10.54 37 66542 247869 110274851
Sinusitis 60.14 10.54 54 66525 296634 110226086
C-reactive protein abnormal 59.38 10.54 5 66574 129690 110393030
Diabetes mellitus 59.27 10.54 162 66417 99219 110423501
Hypersensitivity 59.08 10.54 95 66484 403903 110118817
Discomfort 58.51 10.54 28 66551 214679 110308041
Hepatic enzyme increased 57.51 10.54 65 66514 320827 110201893
Wheezing 57.28 10.54 42 66537 255188 110267532
Diabetic nephropathy 57.10 10.54 32 66547 3476 110519244
Insulin C-peptide decreased 56.94 10.54 13 66566 87 110522633
Cerebrovascular accident 55.27 10.54 236 66343 181048 110341672
Stomatitis 54.99 10.54 49 66530 270193 110252527
Pulmonary interstitial emphysema syndrome 53.47 10.54 18 66561 557 110522163
Cardiac arrest 53.09 10.54 247 66332 196506 110326214
Contraindicated product administered 52.98 10.54 43 66536 248224 110274496
Blood urea increased 52.89 10.54 108 66471 54849 110467871
Arthralgia 51.49 10.54 268 66311 779364 109743356
Sleep disorder 51.00 10.54 28 66551 198616 110324104
Increased insulin requirement 50.71 10.54 14 66565 217 110522503
Ill-defined disorder 50.07 10.54 16 66563 156837 110365883
Bursitis 49.79 10.54 9 66570 129909 110392811
Hypoglycaemic encephalopathy 49.68 10.54 18 66561 695 110522025
Mobility decreased 49.58 10.54 42 66537 237380 110285340
Alveolar lung disease 49.53 10.54 18 66561 701 110522019
Chronic kidney disease 49.17 10.54 128 66451 76163 110446557
Stevens-Johnson syndrome 48.53 10.54 95 66484 46806 110475914
Arrhythmia 48.24 10.54 120 66459 69455 110453265
Nasopharyngitis 47.71 10.54 104 66475 394257 110128463
Swelling 47.24 10.54 87 66492 350954 110171766
Gastrointestinal disorder 46.72 10.54 46 66533 241906 110280814
Toxicity to various agents 45.71 10.54 143 66436 480412 110042308
Joint range of motion decreased 45.50 10.54 9 66570 121823 110400897
Clear cell renal cell carcinoma 44.48 10.54 25 66554 2731 110519989
Migraine 44.35 10.54 24 66555 171628 110351092
Paraesthesia 44.32 10.54 61 66518 276460 110246260
Blood insulin increased 42.92 10.54 14 66565 392 110522328
Fatigue 42.61 10.54 498 66081 1215460 109307260
Oedema peripheral 41.54 10.54 339 66240 328321 110194399
Platelet distribution width increased 41.08 10.54 11 66568 151 110522569
Toe amputation 41.04 10.54 28 66551 4310 110518410
Urosepsis 40.44 10.54 69 66510 30606 110492114
Hepatic function abnormal 40.38 10.54 132 66447 89163 110433557
Hypoglycaemia unawareness 39.96 10.54 12 66567 254 110522466
Inflammation 39.35 10.54 35 66544 193203 110329517
Hypokalaemia 39.32 10.54 215 66364 182233 110340487
Rash 38.97 10.54 312 66267 820652 109702068
Multiple organ dysfunction syndrome 38.40 10.54 187 66392 151523 110371197
Platelet count decreased 37.84 10.54 253 66326 230190 110292530
Respiratory failure 37.54 10.54 240 66339 215092 110307628
Dry mouth 37.47 10.54 39 66540 199909 110322811
Lactic acidosis 37.40 10.54 132 66447 92679 110430041
Wrong product administered 36.90 10.54 39 66540 10921 110511799
Peripheral arterial occlusive disease 36.67 10.54 36 66543 9244 110513476
Lung disorder 36.19 10.54 33 66546 180014 110342706
Peripheral swelling 35.80 10.54 124 66455 403910 110118810
Hepatic encephalopathy 33.92 10.54 61 66518 28195 110494525
Disseminated intravascular coagulation 33.82 10.54 76 66503 41210 110481510
Diabetic foot 33.09 10.54 24 66555 4071 110518649
Hyperlipidaemia 32.79 10.54 69 66510 35779 110486941
Anaemia 32.62 10.54 486 66093 546600 109976120
Central nervous system injury 31.66 10.54 9 66570 156 110522564
Pneumonia aspiration 31.42 10.54 114 66465 81119 110441601
Product monitoring error 30.47 10.54 32 66547 8895 110513825
Cerebral infarction 30.40 10.54 84 66495 51754 110470966
Asthma 30.25 10.54 66 66513 250225 110272495
Type 1 diabetes mellitus 30.12 10.54 32 66547 9015 110513705
Angina pectoris 29.90 10.54 94 66485 62201 110460519
Insulinoma 29.77 10.54 9 66570 195 110522525
Diabetic coma 29.36 10.54 15 66564 1353 110521367
Glycosylated haemoglobin decreased 29.25 10.54 13 66566 859 110521861
Impaired healing 28.97 10.54 46 66533 196671 110326049
Metabolic acidosis 28.96 10.54 128 66451 99616 110423104
Diffuse alveolar damage 28.85 10.54 22 66557 4025 110518695
Acidosis 28.80 10.54 50 66529 22481 110500239
Red blood cell sedimentation rate increased 28.79 10.54 6 66573 78296 110444424
Blood creatine phosphokinase increased 28.64 10.54 103 66476 72974 110449746
Fall 28.17 10.54 515 66064 602967 109919753
Urine output decreased 27.92 10.54 46 66533 19830 110502890
Septic shock 27.71 10.54 176 66403 157352 110365368
Dehiscence 27.69 10.54 12 66567 746 110521974
Urticaria 27.47 10.54 99 66480 318758 110203962
Hyperglycaemic hyperosmolar nonketotic syndrome 27.47 10.54 19 66560 2990 110519730
Loss of personal independence in daily activities 27.28 10.54 30 66549 149990 110372730
Blood lactic acid decreased 27.16 10.54 11 66568 577 110522143
Polyhydramnios 27.10 10.54 16 66563 1917 110520803
Retinopathy 27.10 10.54 22 66557 4407 110518313
Blindness 26.57 10.54 64 66515 36295 110486425
Diabetic hyperglycaemic coma 26.56 10.54 7 66572 90 110522630
Peripheral venous disease 26.11 10.54 9 66570 84108 110438612
Diabetic complication 25.98 10.54 14 66565 1408 110521312
Cold sweat 25.73 10.54 47 66532 21984 110500736
Syncope 25.61 10.54 209 66370 202327 110320393
Product administration error 25.59 10.54 64 66515 37153 110485567
Liver injury 25.29 10.54 32 66547 150381 110372339
Insulin autoimmune syndrome 24.69 10.54 11 66568 731 110521989
Drug ineffective for unapproved indication 24.28 10.54 16 66563 102822 110419898
Neck pain 24.23 10.54 23 66556 123107 110399613
Diabetic gangrene 24.22 10.54 8 66571 233 110522487
Grip strength decreased 24.16 10.54 9 66570 80165 110442555
Night sweats 24.14 10.54 27 66552 133956 110388764
Urinary tract infection 23.98 10.54 301 66278 325981 110196739
Renal cell carcinoma 23.95 10.54 26 66553 7504 110515216
Pulmonary fibrosis 23.92 10.54 16 66563 102026 110420694
General physical health deterioration 23.86 10.54 374 66205 424921 110097799
Thirst 23.72 10.54 45 66534 21662 110501058
Hyperlactacidaemia 23.59 10.54 27 66552 8259 110514461
Intra-abdominal haemorrhage 23.52 10.54 22 66557 5320 110517400
Hip arthroplasty 23.36 10.54 3 66576 55810 110466910
Splenic injury 23.13 10.54 8 66571 269 110522451
Blepharospasm 22.83 10.54 3 66576 54848 110467872
Gamma-glutamyltransferase increased 22.83 10.54 85 66494 61224 110461496
Blood potassium increased 22.68 10.54 57 66522 33192 110489528
Ear infection 22.67 10.54 5 66574 62727 110459993
Ischaemic cardiomyopathy 22.63 10.54 26 66553 7985 110514735
Loss of consciousness 22.41 10.54 198 66381 196108 110326612
Neutropenia 22.36 10.54 133 66446 374487 110148233
Vitamin B1 increased 22.29 10.54 7 66572 173 110522547
Bronchopneumopathy 22.28 10.54 11 66568 922 110521798
Autoimmune disorder 22.14 10.54 6 66573 65477 110457243
Dialysis 21.84 10.54 41 66538 19578 110503142
Adverse event 21.79 10.54 20 66559 108789 110413931
Cellulitis 21.67 10.54 140 66439 125876 110396844
Atrial fibrillation 21.44 10.54 222 66357 229420 110293300
Decubitus ulcer 21.42 10.54 39 66540 18197 110504523
Medical device site abscess 21.23 10.54 7 66572 203 110522517
Type 2 diabetes mellitus 21.19 10.54 47 66532 177185 110345535
Incorrect dose administered 20.90 10.54 120 66459 103521 110419199
Renal injury 20.70 10.54 39 66540 18674 110504046
Dyspnoea 20.64 10.54 838 65741 1106034 109416686
Gangrene 20.55 10.54 36 66543 16305 110506415
Product dispensing error 20.54 10.54 36 66543 16309 110506411
Hypervolaemia 20.49 10.54 71 66508 49389 110473331
Hypophagia 20.47 10.54 74 66505 52552 110470168
Renal disorder 20.47 10.54 71 66508 49408 110473312
Hydrocholecystis 20.34 10.54 9 66570 588 110522132
Haemoglobin decreased 20.25 10.54 234 66345 248493 110274227
Shock hypoglycaemic 20.17 10.54 7 66572 238 110522482
Drug-device interaction 20.16 10.54 6 66573 123 110522597
Insomnia 19.98 10.54 131 66448 360459 110162261
Systemic infection 19.93 10.54 27 66552 9792 110512928
Blood cholesterol increased 19.73 10.54 52 66527 184733 110337987
Intestinal ischaemia 19.51 10.54 35 66544 16144 110506576
Drug resistance 19.37 10.54 5 66574 56369 110466351
Hypoaldosteronism 19.36 10.54 9 66570 660 110522060
Cutaneous amyloidosis 19.29 10.54 5 66574 60 110522660
Bradyarrhythmia 19.23 10.54 19 66560 4915 110517805
Acute respiratory failure 19.20 10.54 93 66486 75167 110447553
Hypercholesterolaemia 19.03 10.54 16 66563 90821 110431899
Urethral cancer 18.99 10.54 5 66574 64 110522656
Localised infection 18.89 10.54 63 66516 42985 110479735
Mucosal inflammation 18.87 10.54 18 66561 96123 110426597
Hypochromasia 18.83 10.54 9 66570 703 110522017
Accidental underdose 18.82 10.54 11 66568 1294 110521426
Pneumonia 18.76 10.54 674 65905 876040 109646680
Hepatic cytolysis 18.69 10.54 5 66574 55048 110467672
Blood sodium abnormal 18.32 10.54 11 66568 1359 110521361
Anti factor V antibody 18.30 10.54 7 66572 315 110522405
Necrosis 18.22 10.54 28 66551 11378 110511342
Ketosis 18.22 10.54 12 66567 1742 110520978
Chest pain 18.17 10.54 323 66256 376052 110146668
Medication error 18.08 10.54 117 66462 105249 110417471
Eosinophilic pneumonia 18.01 10.54 22 66557 7205 110515515
Haematuria 17.99 10.54 98 66481 82907 110439813
Rhabdomyolysis 17.87 10.54 129 66450 120272 110402448
Therapy non-responder 17.77 10.54 43 66536 157264 110365456
Atrioventricular block complete 17.61 10.54 38 66541 20044 110502676
Blood pressure decreased 17.48 10.54 124 66455 114967 110407753
Peripheral ischaemia 17.46 10.54 27 66552 11031 110511689
Blood urea abnormal 17.39 10.54 12 66567 1882 110520838
Agitated depression 17.31 10.54 8 66571 579 110522141
Bradycardia 17.30 10.54 156 66423 155361 110367359
Shock 17.28 10.54 71 66508 53517 110469203
Tachyarrhythmia 17.20 10.54 23 66556 8238 110514482
Oral mucosal eruption 17.18 10.54 10 66569 1167 110521553
Treatment noncompliance 17.07 10.54 88 66491 72902 110449818
Rabbit syndrome 17.02 10.54 7 66572 382 110522338
Cardiac output increased 17.01 10.54 8 66571 603 110522117
Lymphangitis 16.93 10.54 11 66568 1561 110521159
Adjustment disorder with depressed mood 16.90 10.54 3 66576 43880 110478840
Medical device site cellulitis 16.73 10.54 6 66573 225 110522495
Blood potassium abnormal 16.69 10.54 16 66563 3989 110518731
Dyspepsia 16.63 10.54 59 66520 190906 110331814
Peripheral vascular disorder 16.53 10.54 23 66556 8553 110514167
Euglycaemic diabetic ketoacidosis 16.46 10.54 27 66552 11596 110511124
Drug hypersensitivity 16.20 10.54 185 66394 453905 110068815
Cardiac failure acute 16.13 10.54 41 66538 24037 110498683
Glomerular filtration rate decreased 16.07 10.54 46 66533 28910 110493810
Diabetic autonomic neuropathy 15.96 10.54 3 66576 6 110522714
Hypernatraemia 15.93 10.54 34 66545 17799 110504921
Myelosuppression 15.93 10.54 20 66559 94320 110428400
Full blood count abnormal 15.74 10.54 7 66572 56045 110466675
Hypochromic anaemia 15.69 10.54 14 66565 3187 110519533
Product storage error 15.61 10.54 38 66541 21690 110501030
Foreign body in gastrointestinal tract 15.57 10.54 5 66574 133 110522587
Osteomyelitis 15.56 10.54 53 66526 36547 110486173
Glycosylated haemoglobin abnormal 15.55 10.54 7 66572 477 110522243
Type III immune complex mediated reaction 15.51 10.54 9 66570 1044 110521676
Circulatory collapse 15.50 10.54 59 66520 42934 110479786
Stasis dermatitis 15.46 10.54 11 66568 1811 110520909
Sleep disorder due to a general medical condition 15.45 10.54 6 66573 52106 110470614
Ischaemic limb pain 15.43 10.54 4 66575 48 110522672
Somogyi phenomenon 15.35 10.54 3 66576 8 110522712
Pancreatic carcinoma 15.23 10.54 30 66549 14842 110507878
Device material issue 15.19 10.54 7 66572 503 110522217
Wound 15.19 10.54 81 66498 234356 110288364
Blister 15.04 10.54 78 66501 227298 110295422
Cardiomegaly 14.95 10.54 45 66534 29085 110493635
Haemodialysis 14.94 10.54 33 66546 17686 110505034
Diabetic vascular disorder 14.94 10.54 5 66574 152 110522568
Generalised bullous fixed drug eruption 14.93 10.54 8 66571 796 110521924
Live birth 14.85 10.54 12 66567 69472 110453248
Blood creatinine abnormal 14.79 10.54 18 66561 5874 110516846
Atrial enlargement 14.77 10.54 9 66570 1142 110521578
Gastroenteritis 14.62 10.54 54 66525 38746 110483974
Peritonitis 14.55 10.54 48 66531 32559 110490161
Frequent bowel movements 14.44 10.54 13 66566 71377 110451343
Generalised oedema 14.43 10.54 46 66533 30658 110492062
Wrong technique in product usage process 14.38 10.54 96 66483 87252 110435468
Taste disorder 14.35 10.54 11 66568 65376 110457344
Diabetic foot infection 14.21 10.54 8 66571 876 110521844
Leg amputation 14.18 10.54 15 66564 4203 110518517
Microalbuminuria 14.09 10.54 9 66570 1240 110521480
Blood ketone body 13.90 10.54 5 66574 189 110522531
Sprue-like enteropathy 13.84 10.54 10 66569 1686 110521034
Altered state of consciousness 13.84 10.54 70 66509 57556 110465164
Contusion 13.83 10.54 83 66496 233278 110289442
Vitamin B1 decreased 13.76 10.54 8 66571 931 110521789
Internal haemorrhage 13.73 10.54 23 66556 10048 110512672
Hyperchloraemia 13.73 10.54 9 66570 1297 110521423
Osteoarthritis 13.63 10.54 60 66519 182563 110340157
Premature delivery 13.59 10.54 45 66534 30587 110492133
Anti-GAD antibody positive 13.58 10.54 4 66575 79 110522641
Blood alkaline phosphatase increased 13.57 10.54 81 66498 70854 110451866
Infection 13.53 10.54 146 66433 362054 110160666
Myocardial ischaemia 13.48 10.54 41 66538 26643 110496077
Necrotising colitis 13.48 10.54 10 66569 1755 110520965
Weight decreased 13.45 10.54 373 66206 467684 110055036
Lymphoproliferative disorder 13.38 10.54 19 66560 7199 110515521
Mental status changes 13.35 10.54 85 66494 76037 110446683
Lupus-like syndrome 13.30 10.54 4 66575 40788 110481932
Waist circumference increased 13.30 10.54 10 66569 1791 110520929
Infusion site induration 13.30 10.54 9 66570 1367 110521353
Illness 13.28 10.54 18 66561 82153 110440567
Aspartate aminotransferase increased 13.25 10.54 151 66428 159785 110362935
Glucose urine present 13.23 10.54 11 66568 2278 110520442
Bladder transitional cell carcinoma 13.18 10.54 12 66567 2804 110519916
Visual acuity reduced 13.16 10.54 46 66533 32127 110490593
Cholelithiasis 13.16 10.54 74 66505 63348 110459372
Vitreous haemorrhage 13.06 10.54 15 66564 4605 110518115
Hypertensive nephropathy 13.02 10.54 8 66571 1030 110521690
Bronchiectasis 13 10.54 3 66576 36490 110486230
Knee arthroplasty 12.93 10.54 12 66567 64936 110457784
Anxiety 12.93 10.54 139 66440 344939 110177781
Glomerular filtration rate abnormal 12.84 10.54 11 66568 2372 110520348
Liver function test increased 12.75 10.54 21 66558 88527 110434193
Thyroid gland abscess 12.73 10.54 4 66575 99 110522621
Dementia 12.71 10.54 45 66534 31628 110491092
Muscle spasticity 12.70 10.54 3 66576 35912 110486808
COVID-19 treatment 12.69 10.54 6 66573 457 110522263
Electrocardiogram abnormal 12.68 10.54 32 66547 18677 110504043
Myalgia 12.62 10.54 196 66383 222185 110300535
Exostosis 12.50 10.54 6 66573 45950 110476770
Epilepsy 12.45 10.54 26 66553 100183 110422537
Streptococcal infection 12.43 10.54 23 66556 10867 110511853
Foot amputation 12.41 10.54 8 66571 1120 110521600
Hypoalbuminaemia 12.35 10.54 42 66537 28932 110493788
Corneal dystrophy 12.28 10.54 5 66574 266 110522454
Orthopnoea 12.23 10.54 23 66556 10998 110511722
Tachycardia 12.20 10.54 198 66381 226447 110296273
Diabetic ketoacidotic hyperglycaemic coma 12.14 10.54 5 66574 274 110522446
Pre-eclampsia 12.12 10.54 20 66559 8630 110514090
Epidermolysis 12.09 10.54 8 66571 1170 110521550
Renal artery stenosis 12.09 10.54 13 66566 3713 110519007
Electrocardiogram T wave amplitude decreased 12.05 10.54 7 66572 814 110521906
Chromaturia 12.03 10.54 42 66537 29318 110493402
Osteonecrosis of jaw 11.98 10.54 7 66572 48010 110474710
Anisocytosis 11.98 10.54 8 66571 1188 110521532
Staphylococcal sepsis 11.98 10.54 30 66549 17424 110505296
Acute painful neuropathy of rapid glycaemic control 11.90 10.54 3 66576 32 110522688
Disorientation 11.83 10.54 78 66501 70593 110452127
Supraventricular extrasystoles 11.77 10.54 19 66560 8054 110514666
Haematocrit decreased 11.70 10.54 74 66505 66043 110456677
Multiple sclerosis relapse 11.61 10.54 8 66571 50232 110472488
Neuropathic arthropathy 11.54 10.54 6 66573 561 110522159
Blood ketone body increased 11.54 10.54 7 66572 881 110521839
Hypoproteinaemia 11.54 10.54 16 66563 5929 110516791
Accidental exposure to product 11.51 10.54 8 66571 50000 110472720
Hydrocele 11.49 10.54 8 66571 1273 110521447
Dry eye 11.48 10.54 10 66569 55783 110466937
Bladder cyst 11.47 10.54 4 66575 138 110522582
Blood lactate dehydrogenase increased 11.46 10.54 55 66524 44279 110478441
Gastrointestinal haemorrhage 11.43 10.54 151 66428 165367 110357353
Systemic candida 11.30 10.54 21 66558 9953 110512767
Respiratory tract infection 11.26 10.54 16 66563 71601 110451119
Necrotising fasciitis 11.25 10.54 18 66561 7573 110515147
Finger deformity 11.25 10.54 3 66576 33089 110489631
Electrocardiogram ST segment abnormal 11.20 10.54 9 66570 1776 110520944
Therapeutic response decreased 11.20 10.54 26 66553 96473 110426247
Diabetic ketosis 11.20 10.54 7 66572 929 110521791
Procalcitonin increased 11.18 10.54 13 66566 4043 110518677
Injection site reaction 11.16 10.54 23 66556 89047 110433673
Psoriasis 11.06 10.54 45 66534 139948 110382772
Bone contusion 10.88 10.54 8 66571 1386 110521334
Bundle branch block left 10.86 10.54 24 66555 12864 110509856
Lip erosion 10.85 10.54 9 66570 1857 110520863
Cardiac failure chronic 10.84 10.54 25 66554 13786 110508934
Foot deformity 10.84 10.54 8 66571 48472 110474248
Flushing 10.78 10.54 30 66549 104706 110418014
Sinus arrest 10.71 10.54 13 66566 4229 110518491
Lipase increased 10.69 10.54 30 66549 18642 110504078
Immunodeficiency 10.67 10.54 5 66574 38833 110483887
Post thrombotic syndrome 10.64 10.54 6 66573 659 110522061
Pleural effusion 10.61 10.54 158 66421 177551 110345169
Joint stiffness 10.60 10.54 15 66564 67228 110455492
Colitis ulcerative 10.55 10.54 19 66560 77344 110445376

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
ATC A10AB01 ALIMENTARY TRACT AND METABOLISM
DRUGS USED IN DIABETES
INSULINS AND ANALOGUES
Insulins and analogues for injection, fast-acting
ATC A10AC01 ALIMENTARY TRACT AND METABOLISM
DRUGS USED IN DIABETES
INSULINS AND ANALOGUES
Insulins and analogues for injection, intermediate-acting
ATC A10AD01 ALIMENTARY TRACT AND METABOLISM
DRUGS USED IN DIABETES
INSULINS AND ANALOGUES
Insulins and analogues for injection, intermediate- or long-acting combined with fast-acting
ATC A10AE01 ALIMENTARY TRACT AND METABOLISM
DRUGS USED IN DIABETES
INSULINS AND ANALOGUES
Insulins and analogues for injection, long-acting
ATC A10AF01 ALIMENTARY TRACT AND METABOLISM
DRUGS USED IN DIABETES
INSULINS AND ANALOGUES
Insulins and analogues for inhalation
FDA CS M0011417 Insulin
MeSH PA D007004 Hypoglycemic Agents
CHEBI has role CHEBI:35526 hypoglycemic agent
FDA EPC N0000175944 Insulin
CHEBI has role CHEBI:35554 cardiovascular drug
CHEBI has role CHEBI:35674 antihypertensive agent
CHEBI has role CHEBI:145947 antiatherosclerotic agent
CHEBI has role CHEBI:22587 antiviral agent
CHEBI has role CHEBI:35469 antidepressant
CHEBI has role CHEBI:35476 antipsychotic agent
CHEBI has role CHEBI:35480 analgesic
CHEBI has role CHEBI:35705 immunosuppressive agent
CHEBI has role CHEBI:35821 anticholesteremic drug
CHEBI has role CHEBI:39456 antiglaucoma drug
CHEBI has role CHEBI:48407 antiparkinson drug
CHEBI has role CHEBI:50864 insulin-sensitizing drug
CHEBI has role CHEBI:66981 ophthalmology drug
CHEBI has role CHEBI:73336 vulnerary
CHEBI has role CHEBI:74518 anti-obesity agent
CHEBI has role CHEBI:76916 hyperglycemic agent
CHEBI has role CHEBI:231911 renoprotective agent

Related Drugs by ATC class:

A10AB Insulins and analogues for injection, fast-acting 5 drugs
insulin aspartinsulin beefinsulin glulisineinsulin lisproinsulin pork
A10AC Insulins and analogues for injection, intermediate-acting 3 drugs
insulin beefinsulin lisproinsulin pork
A10AD Insulins and analogues for injection, intermediate- or long-acting combined with fast-acting 5 drugs
insulin aspartinsulin beefinsulin degludecinsulin lisproinsulin pork
A10AE Insulins and analogues for injection, long-acting 9 drugs
insulin beefinsulin degludecinsulin detemirinsulin glargineinsulin icodecinsulin porkliraglutidelixisenatidesemaglutide

Drug Use | Suggest Off label Use Form| |View source of the data|

DiseaseRelationSNOMED_IDDOID
Diabetes mellitus type 2 indication 44054006 DOID:9352
Diabetes mellitus type 1 indication 46635009 DOID:9744
Overdose of beta-adrenergic blocking drug off-label use 296335002
Overdose of calcium-channel blockers off-label use 296355001




🐶 Veterinary Drug Use

SpeciesUseRelation
Cats Diabetes mellitus Indication
Dogs Diabetes mellitus Indication

🐶 Veterinary products

ProductApplicantIngredients
ProZinc Boehringer lngelheim Animal Health USA Inc. 1

Acid dissociation constants calculated using MoKa v3.0.0

None

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])		Mechanism
action		Bioact sourceMoA source
Insulin receptor Kinase AGONIST DRUG LABEL DRUG LABEL
Tyrosine-protein kinase Lck Kinase IC50 4.74 CHEMBL
Insulin receptor Kinase IC50 8.71 CHEMBL

External reference:

IDSource
D03230 KEGG_DRUG
4020217 VUID
N0000179707 NUI
4017559 VANDF
4017569 VANDF
4019786 VANDF
4021631 VANDF
CHEBI:5931 CHEBI
CHEMBL1201631 ChEMBL_ID
CHEMBL1201540 ChEMBL_ID
CHEMBL1201627 ChEMBL_ID
CHEMBL1201644 ChEMBL_ID
DB00030 DRUGBANK_ID
1372744 RXNORM
4885 MMSL
4886 MMSL
d00262 MMSL
d04369 MMSL
000869 NDDF
000870 NDDF
006518 NDDF
126210001 SNOMEDCT_US
39487003 SNOMEDCT_US
412222002 SNOMEDCT_US
412223007 SNOMEDCT_US
417423002 SNOMEDCT_US
420609005 SNOMEDCT_US
67866001 SNOMEDCT_US
96367001 SNOMEDCT_US
C0795635 UMLSCUI
D007328 MESH_DESCRIPTOR_UI
5186 INN_ID
118984375 PUBCHEM_CID
5012 IUPHAR_LIGAND_ID
1Y17CTI5SR UNII

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
Humulin R HUMAN OTC DRUG LABEL 1 0002-0213 INJECTION, SOLUTION 100 [iU] PARENTERAL BLA 29 sections
Humulin R HUMAN OTC DRUG LABEL 1 0002-8215 INJECTION, SOLUTION 100 [iU] PARENTERAL BLA 29 sections
Humulin N HUMAN OTC DRUG LABEL 1 0002-8315 INJECTION, SUSPENSION 100 [iU] SUBCUTANEOUS BLA 29 sections
HumulinR U-500 HUMAN PRESCRIPTION DRUG LABEL 1 0002-8501 INJECTION, SOLUTION 500 [iU] SUBCUTANEOUS BLA 30 sections
Humulin 70/30 HUMAN OTC DRUG LABEL 1 0002-8715 INJECTION, SUSPENSION 100 [iU] SUBCUTANEOUS BLA 29 sections
Humulin 70/30 KwikPen HUMAN OTC DRUG LABEL 1 0002-8803 INJECTION, SUSPENSION 100 [iU] SUBCUTANEOUS BLA 29 sections
Humulin N HUMAN OTC DRUG LABEL 1 0002-8805 INJECTION, SUSPENSION 100 [iU] SUBCUTANEOUS BLA 29 sections
HumulinR U-500 KwikPen HUMAN PRESCRIPTION DRUG LABEL 1 0002-8824 INJECTION, SOLUTION 500 [iU] SUBCUTANEOUS BLA 30 sections
NovolinR HUMAN OTC DRUG LABEL 1 0169-1833 INJECTION, SOLUTION 100 [iU] SUBCUTANEOUS BLA 25 sections
NovolinN HUMAN OTC DRUG LABEL 1 0169-1834 INJECTION, SUSPENSION 100 [iU] SUBCUTANEOUS BLA 23 sections
Novolin70/30 HUMAN OTC DRUG LABEL 1 0169-1837 INJECTION, SUSPENSION 100 [iU] SUBCUTANEOUS BLA 24 sections
NovolinR HUMAN OTC DRUG LABEL 1 0169-3003 INJECTION, SOLUTION 100 [iU] SUBCUTANEOUS BLA 25 sections
NovolinN HUMAN OTC DRUG LABEL 1 0169-3004 INJECTION, SUSPENSION 100 [iU] SUBCUTANEOUS BLA 23 sections
Novolin70/30 HUMAN OTC DRUG LABEL 1 0169-3007 INJECTION, SUSPENSION 100 [iU] SUBCUTANEOUS BLA 24 sections
MYXREDLIN HUMAN PRESCRIPTION DRUG LABEL 1 0338-0126 INJECTION, SOLUTION 1 [iU] INTRAVENOUS BLA 25 sections
AFREZZA HUMAN PRESCRIPTION DRUG LABEL 1 47918-874 POWDER, METERED 4 [arbU] RESPIRATORY (INHALATION) BLA 34 sections
AFREZZA HUMAN PRESCRIPTION DRUG LABEL 1 47918-878 POWDER, METERED 8 [arbU] RESPIRATORY (INHALATION) BLA 34 sections
AFREZZA HUMAN PRESCRIPTION DRUG LABEL 1 47918-891 POWDER, METERED 12 [arbU] RESPIRATORY (INHALATION) BLA 34 sections
Humulin N HUMAN OTC DRUG LABEL 1 50090-0352 INJECTION, SUSPENSION 100 [iU] SUBCUTANEOUS NDA 31 sections
HUMULIN R HUMAN OTC DRUG LABEL 1 50090-0353 INJECTION, SOLUTION 100 [iU] PARENTERAL BLA 29 sections
Novolin70/30 HUMAN OTC DRUG LABEL 1 50090-0403 INJECTION, SUSPENSION 100 [iU] SUBCUTANEOUS BLA 24 sections
Humulin 70/30 HUMAN OTC DRUG LABEL 1 50090-0444 INJECTION, SUSPENSION 100 [iU] SUBCUTANEOUS NDA 29 sections
Humulin N HUMAN OTC DRUG LABEL 1 54868-1429 INJECTION, SUSPENSION 100 [iU] SUBCUTANEOUS NDA 11 sections
Humalog 70/30 HUMAN OTC DRUG LABEL 1 54868-2746 INJECTION, SUSPENSION 100 [iU] SUBCUTANEOUS NDA 9 sections
Novolin70/30 HUMAN OTC DRUG LABEL 1 54868-3474 INJECTION, SUSPENSION 100 [USPU] SUBCUTANEOUS NDA 13 sections
Humulin R HUMAN OTC DRUG LABEL 1 54868-3619 INJECTION, SOLUTION 100 [iU] SUBCUTANEOUS NDA 23 sections
Novolin R HUMAN OTC DRUG LABEL 1 64725-1833 INJECTION, SOLUTION 100 [iU] SUBCUTANEOUS NDA 26 sections
Novolin N HUMAN OTC DRUG LABEL 1 64725-1834 INJECTION, SUSPENSION 100 [iU] SUBCUTANEOUS NDA 7 sections
Novolin 70/30 HUMAN OTC DRUG LABEL 1 64725-1837 INJECTION, SUSPENSION 100 [USPU] SUBCUTANEOUS NDA 11 sections