insulin human 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definition	Drug id	CAS RN
	5003	11061-68-0

Description:

Molecule	Description
Synonyms: insulin (human) insulin insulin regular human insulin susp isophane recombinant human insulin susp isophane semisynthetic purified human insulin zinc susp extended recombinant human insulin zinc susp recombinant human insulin zinc susp semisynthetic purified human insulin human base insulin human isophane insulin human insulin recombinant human insulin human (genetical recombination) humulin insulin recombinant purified human	Insulin (51 aa, ~6 kDa) is encoded by the human INS gene. This protein is involved in the direct regulation of glucose metabolism. Molecular weight: 5807.63 Formula: C257H383N65O77S6 CLOGP: LIPINSKI: None HAC: None HDO: None TPSA: 2299.07 ALOGS: ROTB: None

Molecule

Description

Synonyms:

insulin (human)
insulin
insulin regular human
insulin susp isophane recombinant human
insulin susp isophane semisynthetic purified human
insulin zinc susp extended recombinant human
insulin zinc susp recombinant human
insulin zinc susp semisynthetic purified human
insulin human base
insulin human isophane
insulin human
insulin recombinant human
insulin human (genetical recombination)
humulin
insulin recombinant purified human

Insulin (51 aa, ~6 kDa) is encoded by the human INS gene. This protein is involved in the direct regulation of glucose metabolism.

Molecular weight: 5807.63
Formula: C257H383N65O77S6
CLOGP:
LIPINSKI: None
HAC: None
HDO: None
TPSA: 2299.07
ALOGS:
ROTB: None

Drug dosage:

Dose	Unit	Route
40	U	P
40	U	P
40	U	P
40	U	P
40	U	P

ADMET properties:

None

Approvals:

Date	Agency	Company	Orphan
Feb. 21, 1997	EMA	Sanofi-Aventis Deutschland GmbH
Oct. 28, 1982	FDA	LILLY

FDA Adverse Event Reporting System (Female)

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MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Blood glucose increased	1052.42	11.25	645	37681	83111	63367585
Hypoglycaemia	968.93	11.25	544	37782	59521	63391175
Blood glucose decreased	404.47	11.25	214	38112	20738	63429958
Hyperglycaemia	326.09	11.25	240	38086	41627	63409069
Diabetes mellitus inadequate control	293.33	11.25	155	38171	14971	63435725
Diabetic ketoacidosis	251.94	11.25	156	38170	20349	63430347
Blood glucose fluctuation	229.89	11.25	91	38235	4485	63446211
Toothache	228.14	11.25	143	38183	19056	63431640
Glycosylated haemoglobin increased	217.84	11.25	119	38207	12279	63438417
Pharyngitis	209.59	11.25	138	38188	20005	63430691

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FDA Adverse Event Reporting System (Male)

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MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Hypoglycaemia	776.60	11.24	552	34844	54088	34867447
Blood glucose increased	749.18	11.24	585	34811	66133	34855402
Blood glucose decreased	293.56	11.24	177	35219	13060	34908475
Hyperglycaemia	234.31	11.24	242	35154	39238	34882297
Diabetes mellitus inadequate control	181.51	11.24	132	35264	13332	34908203
Glycosylated haemoglobin increased	145.51	11.24	108	35288	11252	34910283
Diabetic ketoacidosis	128.14	11.24	122	35274	17910	34903625
Anti-insulin antibody positive	125.49	11.24	31	35365	167	34921368
Blood glucose fluctuation	113.35	11.24	63	35333	3981	34917554
Completed suicide	73.95	11.24	7	35389	98161	34823374

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FDA Adverse Event Reporting System (Geriatric)

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MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Hypoglycaemia	1430.78	10.40	908	58418	100686	79584376
Blood glucose increased	887.82	10.40	713	58613	114262	79570800
Hyperglycaemia	508.23	10.40	420	58906	69915	79615147
Blood glucose decreased	389.73	10.40	243	59083	25991	79659071
Diabetes mellitus inadequate control	348.49	10.40	220	59106	24044	79661018
Diabetic ketoacidosis	282.95	10.40	221	59105	33901	79651161
Glycosylated haemoglobin increased	238.16	10.40	159	59167	19101	79665961
Blood glucose fluctuation	232.62	10.40	109	59217	6573	79678489
Anti-insulin antibody positive	199.96	10.40	46	59280	250	79684812
Hypoglycaemic coma	142.46	10.40	70	59256	4690	79680372

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FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

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Source	Code	Description
ATC	A10AB01	ALIMENTARY TRACT AND METABOLISM DRUGS USED IN DIABETES INSULINS AND ANALOGUES Insulins and analogues for injection, fast-acting
ATC	A10AC01	ALIMENTARY TRACT AND METABOLISM DRUGS USED IN DIABETES INSULINS AND ANALOGUES Insulins and analogues for injection, intermediate-acting
ATC	A10AD01	ALIMENTARY TRACT AND METABOLISM DRUGS USED IN DIABETES INSULINS AND ANALOGUES Insulins and analogues for injection, intermediate- or long-acting combined with fast-acting
ATC	A10AE01	ALIMENTARY TRACT AND METABOLISM DRUGS USED IN DIABETES INSULINS AND ANALOGUES Insulins and analogues for injection, long-acting
ATC	A10AF01	ALIMENTARY TRACT AND METABOLISM DRUGS USED IN DIABETES INSULINS AND ANALOGUES Insulins and analogues for inhalation
CHEBI has role	CHEBI:35526	antidiabetic
FDA CS	M0011417	Insulin
FDA EPC	N0000175944	Insulin
MeSH PA	D007004	Hypoglycemic Agents

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Drug Use | Suggest Off label Use Form| |View source of the data|

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Disease	Relation	SNOMED_ID	DOID
Diabetes mellitus type 2	indication	44054006	DOID:9352
Diabetes mellitus type 1	indication	46635009	DOID:9744
Overdose of beta-adrenergic blocking drug	off-label use	296335002
Overdose of calcium-channel blockers	off-label use	296355001

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🐶 Veterinary Drug Use

Species	Use	Relation
Cats	Diabetes mellitus	Indication
Dogs	Diabetes mellitus	Indication

🐶 Veterinary products

Product	Applicant	Ingredients
ProZinc	Boehringer lngelheim Animal Health USA Inc.	1

Acid dissociation constants calculated using MoKa v3.0.0

None

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

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Target	Class	Pharos	UniProt	Action	Type	Activity value (-log[M])	Bioact source	MoA source
Insulin receptor	Kinase	P06213	INSR_HUMAN	AGONIST			DRUG LABEL	DRUG LABEL
Tyrosine-protein kinase Lck	Kinase	P06239	LCK_HUMAN		IC50	4.74	CHEMBL
Insulin receptor	Kinase		INSR_RAT		IC50	8.71	CHEMBL

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External reference:

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ID	Source
000869	NDDF
000870	NDDF
006518	NDDF
118984375	PUBCHEM_CID
126210001	SNOMEDCT_US
1372744	RXNORM
1Y17CTI5SR	UNII
39487003	SNOMEDCT_US
4017559	VANDF
4017569	VANDF

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Pharmaceutical products:

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Product	Category	Ingredients	NDC	Form	Quantity	Route	Marketing	Label
Humulin 70/30	HUMAN OTC DRUG LABEL	1	0002-8715	INJECTION, SUSPENSION	100 [iU]	SUBCUTANEOUS	BLA	30 sections
Humulin 70/30	HUMAN OTC DRUG LABEL	1	0002-8715	INJECTION, SUSPENSION	100 [iU]	SUBCUTANEOUS	BLA	30 sections
Humulin 70/30	HUMAN OTC DRUG LABEL	1	0002-8715	INJECTION, SUSPENSION	100 [iU]	SUBCUTANEOUS	BLA	30 sections
Humulin 70/30 KwikPen	HUMAN OTC DRUG LABEL	1	0002-8803	INJECTION, SUSPENSION	100 [iU]	SUBCUTANEOUS	BLA	30 sections
Humulin 70/30 KwikPen	HUMAN OTC DRUG LABEL	1	0002-8803	INJECTION, SUSPENSION	100 [iU]	SUBCUTANEOUS	BLA	30 sections
Humulin 70/30 KwikPen	HUMAN OTC DRUG LABEL	1	0002-8803	INJECTION, SUSPENSION	100 [iU]	SUBCUTANEOUS	BLA	30 sections
Humulin N	HUMAN OTC DRUG LABEL	1	0002-8315	INJECTION, SUSPENSION	100 [iU]	SUBCUTANEOUS	BLA	30 sections
Humulin N	HUMAN OTC DRUG LABEL	1	0002-8315	INJECTION, SUSPENSION	100 [iU]	SUBCUTANEOUS	BLA	30 sections
Humulin N	HUMAN OTC DRUG LABEL	1	0002-8315	INJECTION, SUSPENSION	100 [iU]	SUBCUTANEOUS	BLA	30 sections
Humulin N	HUMAN OTC DRUG LABEL	1	0002-8805	INJECTION, SUSPENSION	100 [iU]	SUBCUTANEOUS	BLA	30 sections

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