All FDA-approved EMA-approved PMDA-approved
Target Card Uniprot Example: P23975

insulin detemir 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | PK/Tox | Related Drugs | BioActivity |

Stem definition	Drug id	CAS RN
	4985	169148-63-4

Description:

Molecule	Description
Synonyms: insulin detemir levemir insulin detemir recombinant insulin detemir [rDNA origin] NN304 NN 304 NN-304	A recombinant long-acting insulin and hypoglycemic agent in which a MYRISTIC ACID is conjugated to a LYSINE at position B29. It is used to manage BLOOD GLUCOSE levels in patients with DIABETES MELLITUS. Molecular weight: 5916.89 Formula: C267H402N64O76S6 CLOGP: LIPINSKI: None HAC: None HDO: None TPSA: 2252.82 ALOGS: ROTB: None

Drug dosage:

Dose	Unit	Route
40	U	P

ADMET properties:

None

Predicted pharmacokinetic/toxicological properties (PK-AZ):

None

Approvals:

Date	Agency	Company	Orphan
June 16, 2005	FDA	NOVO NORDISK INC
June 1, 2004	EMA

FDA Adverse Event Reporting System (Female)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Blood glucose increased	715.20	14.29	436	31730	94810	90501471
Hypoglycaemia	542.71	14.29	327	31839	69521	90526760
Gangrene	501.03	14.29	184	31982	12692	90583589
Arterial occlusive disease	466.38	14.29	173	31993	12273	90584008
Carotid artery thrombosis	425.59	14.29	149	32017	8943	90587338
Neurologic neglect syndrome	418.01	14.29	146	32020	8701	90587580
Diabetic ketoacidosis	415.20	14.29	193	31973	24214	90572067
Adjustment disorder	390.75	14.29	142	32024	9500	90586781
Personality disorder	369.47	14.29	146	32020	12298	90583983
Sensory loss	342.21	14.29	154	32012	17921	90578360
Hemiplegia	335.88	14.29	147	32019	16013	90580268
Affect lability	326.47	14.29	149	32017	17914	90578367
Motor dysfunction	317.56	14.29	149	32017	19081	90577200
Coordination abnormal	314.67	14.29	153	32013	21203	90575078
Skin haemorrhage	314.51	14.29	153	32013	21227	90575054
Angina pectoris	313.44	14.29	187	31979	38973	90557308
Sinus congestion	292.43	14.29	158	32008	27266	90569015
Sneezing	274.40	14.29	156	32010	29713	90566568
Eating disorder	267.02	14.29	150	32016	27923	90568358
Respiratory tract congestion	264.91	14.29	148	32018	27262	90569019
Sinus disorder	261.45	14.29	159	32007	34288	90561993
Hemiparesis	254.75	14.29	152	32014	31667	90564614
Aphasia	234.56	14.29	161	32005	42651	90553630
Cataract	233.19	14.29	198	31968	71894	90524387
Muscle spasticity	232.65	14.29	149	32017	35173	90561108
Cerebrovascular accident	227.97	14.29	249	31917	123284	90472997
Blood glucose decreased	216.89	14.29	123	32043	23306	90572975
Dysarthria	210.57	14.29	166	32000	54316	90541965
Hyperglycaemia	194.18	14.29	154	32012	50816	90545465
Skin exfoliation	186.52	14.29	170	31996	67743	90528538
Diabetes mellitus inadequate control	183.56	14.29	102	32064	18582	90577699
Cystitis	179.31	14.29	165	32001	66553	90529728
Palpitations	155.48	14.29	216	31950	136512	90459769
Lactic acidosis	153.79	14.29	134	32032	50329	90545952
Influenza like illness	153.01	14.29	165	32001	80446	90515835
Rhinorrhoea	147.38	14.29	169	31997	88147	90508134
Chest discomfort	146.12	14.29	211	31955	138154	90458127
Blood pressure increased	132.41	14.29	245	31921	196972	90399309
Glycosylated haemoglobin increased	128.85	14.29	76	32090	15486	90580795
Blood glucose fluctuation	128.00	14.29	53	32113	5030	90591251
Dysphagia	122.60	14.29	174	31992	112104	90484177
Drug ineffective	122.23	14.29	190	31976	1384108	89212173
Ketoacidosis	119.82	14.29	52	32114	5543	90590738
Influenza	119.65	14.29	193	31973	139071	90457210
Drug intolerance	116.20	14.29	12	32154	447579	90148702
Arthritis	101.34	14.29	199	31967	167116	90429165
Glossodynia	100.48	14.29	3	32163	321776	90274505
Contraindicated product administered	99.91	14.29	3	32163	320136	90276145
Psoriasis	99.68	14.29	184	31982	147570	90448711
Infusion related reaction	96.61	14.29	16	32150	416764	90179517
Alopecia	94.80	14.29	29	32137	495042	90101239
Treatment failure	94.30	14.29	3	32163	303925	90292356
Fall	92.71	14.29	377	31789	481433	90114848
Hypoglycaemic unconsciousness	91.29	14.29	26	32140	788	90595493
Joint swelling	88.55	14.29	34	32132	503266	90093015
Arthropathy	82.80	14.29	15	32151	366227	90230054
Pericarditis	82.62	14.29	3	32163	270148	90326133
Premature delivery	80.01	14.29	83	32083	38679	90557602
Diabetic retinopathy	77.72	14.29	31	32135	2671	90593610
Hypoglycaemic coma	74.69	14.29	31	32135	2959	90593322
Acute kidney injury	74.13	14.29	266	31900	320121	90276160
Hepatic enzyme increased	72.97	14.29	19	32147	360717	90235564
Muscular weakness	66.32	14.29	192	31974	206474	90389807
Duodenal ulcer perforation	65.83	14.29	3	32163	221285	90374996
Off label use	62.46	14.29	193	31973	1102059	89494222
Anti-insulin antibody positive	62.08	14.29	13	32153	101	90596180
Insulin resistance	62.03	14.29	21	32145	1137	90595144
Impaired healing	61.44	14.29	6	32160	234193	90362088
Musculoskeletal stiffness	61.15	14.29	15	32151	296517	90299764
Irritable bowel syndrome	58.05	14.29	4	32162	207444	90388837
Blood glucose abnormal	57.46	14.29	38	32128	9454	90586827
Therapeutic product effect decreased	57.31	14.29	14	32152	277557	90318724
Injection site mass	56.16	14.29	53	32113	22037	90574244
Arthralgia	53.32	14.29	124	32042	778398	89817883
Lower respiratory tract infection	53.02	14.29	12	32154	250647	90345634
Abdominal discomfort	52.74	14.29	55	32111	477273	90119008
Discomfort	52.58	14.29	16	32150	274319	90321962
Vomiting	51.04	14.29	464	31702	787829	89808452
Exposure during pregnancy	49.29	14.29	191	31975	238219	90358062
Stomatitis	49.19	14.29	18	32148	274680	90321601
Foetal exposure during pregnancy	48.94	14.29	68	32098	42907	90553374
Liver injury	48.58	14.29	3	32163	170564	90425717
Cough	47.48	14.29	257	31909	368705	90227576
Systemic infection	46.70	14.29	26	32140	4749	90591532
Infection	44.34	14.29	38	32128	362056	90234225
Hypoglycaemia neonatal	43.50	14.29	16	32150	1106	90595175
Mobility decreased	42.30	14.29	18	32148	250716	90345565
Anxiety	41.35	14.29	218	31948	309554	90286727
Blood cholesterol increased	40.09	14.29	12	32154	208000	90388281
Fibromyalgia	39.57	14.29	12	32154	206257	90390024
Infective pulmonary exacerbation of cystic fibrosis	38.99	14.29	31	32135	10248	90586033
Injury	38.73	14.29	11	32155	197338	90398943
Injection site urticaria	37.94	14.29	39	32127	17972	90578309
C-reactive protein increased	37.72	14.29	9	32157	181380	90414901
Therapeutic product effect incomplete	37.70	14.29	11	32155	193885	90402396
Injection site pruritus	37.47	14.29	68	32098	53766	90542515
Visceral congestion	37.27	14.29	11	32155	379	90595902
Pre-eclampsia	37.03	14.29	31	32135	11017	90585264
Ill-defined disorder	36.86	14.29	10	32156	184881	90411400
Psoriatic arthropathy	36.02	14.29	18	32148	228317	90367964
Sleep disorder	33.75	14.29	14	32152	198016	90398265
Hypoglycaemic seizure	33.35	14.29	11	32155	549	90595732
Wound	32.22	14.29	36	32130	302944	90293337
Joint range of motion decreased	31.85	14.29	5	32161	135638	90460643
Asthenia	31.85	14.29	309	31857	533442	90062839
Pancreatitis	31.77	14.29	74	32092	69752	90526529
Swelling	31.73	14.29	63	32103	418995	90177286
Injection site erythema	31.06	14.29	91	32075	98411	90497870
Anuria	31.05	14.29	32	32134	14786	90581495
Blister	30.91	14.29	27	32139	254971	90341310
Sinusitis	30.87	14.29	218	31948	342870	90253411
Increased insulin requirement	30.84	14.29	7	32159	82	90596199
Rash	30.67	14.29	162	32004	795938	89800343
Hypersensitivity	30.59	14.29	73	32093	454604	90141677
Malaise	30.56	14.29	330	31836	585656	90010625
Hyperkalaemia	29.72	14.29	69	32097	64895	90531386
Diabetic neuropathy	29.37	14.29	19	32147	4555	90591726
Drug hypersensitivity	29.19	14.29	77	32089	463532	90132749
Nausea	29.18	14.29	554	31612	1109762	89486519
Osteoarthritis	28.58	14.29	17	32149	195713	90400568
Product use issue	28.19	14.29	46	32120	329873	90266408
Product use in unapproved indication	26.80	14.29	49	32117	336187	90260094
Confusional state	26.77	14.29	231	31935	385974	90210307
Premature baby	26.07	14.29	38	32128	25039	90571242
Blood ketone body	26.00	14.29	6	32160	76	90596205
Type 2 diabetes mellitus	25.26	14.29	21	32145	203223	90393058
Dyspepsia	25.22	14.29	20	32146	198140	90398141
Anti-insulin antibody	25.00	14.29	5	32161	30	90596251
Multiple lentigines syndrome	24.71	14.29	7	32159	208	90596073
Pneumonia	24.42	14.29	339	31827	637720	89958561
Febrile neutropenia	24.20	14.29	13	32153	158336	90437945
Euglycaemic diabetic ketoacidosis	24.16	14.29	19	32147	6182	90590099
Diabetic retinal oedema	23.98	14.29	8	32158	414	90595867
Anaemia vitamin B12 deficiency	23.92	14.29	9	32157	663	90595618
Dextrocardia	23.75	14.29	5	32161	40	90596241
Hypoglycaemia unawareness	23.44	14.29	6	32160	120	90596161
Rhonchi	23.23	14.29	14	32152	2964	90593317
Anti-insulin antibody increased	23.13	14.29	5	32161	46	90596235
Rheumatoid arthritis	23.12	14.29	213	31953	362401	90233880
Pulmonary fibrosis	23.01	14.29	5	32161	107498	90488783
Gestational hypertension	22.87	14.29	14	32152	3048	90593233
Peripheral swelling	22.80	14.29	73	32093	413033	90183248
Inflammation	22.76	14.29	18	32148	178574	90417707
Wound infection	22.67	14.29	5	32161	106397	90489884
Neutropenia	22.53	14.29	28	32138	224876	90371405
Gait inability	22.41	14.29	12	32154	146444	90449837
Intentional product use issue	21.73	14.29	27	32139	216865	90379416
Dry mouth	21.69	14.29	20	32146	184039	90412242
Injection site rash	21.41	14.29	34	32132	24139	90572142
Gastrointestinal disorder	21.29	14.29	160	32006	256527	90339754
Neonatal anoxia	20.83	14.29	3	32163	0	90596281
Contusion	20.56	14.29	36	32130	251180	90345101
Grip strength decreased	20.45	14.29	4	32162	92572	90503709
Pancreatitis acute	20.38	14.29	39	32127	32076	90564205
Blood insulin decreased	20.30	14.29	4	32162	22	90596259
Upper respiratory tract irritation	20.27	14.29	6	32160	209	90596072
Prescribed overdose	19.98	14.29	5	32161	97620	90498661
Peripheral venous disease	19.91	14.29	3	32163	83918	90512363
Therapy non-responder	19.78	14.29	12	32154	136692	90459589
Cataract subcapsular	19.69	14.29	8	32158	723	90595558
Knee arthroplasty	19.67	14.29	3	32163	83179	90513102
Red blood cell sedimentation rate increased	19.49	14.29	3	32163	82592	90513689
Acute myocardial infarction	19.30	14.29	40	32126	34850	90561431
Migraine	18.76	14.29	24	32142	190368	90405913
Diabetic nephropathy	18.50	14.29	10	32156	1724	90594557
Hypertension	18.19	14.29	92	32074	457440	90138841
Gastric disorder	18.14	14.29	38	32128	33346	90562935
Product administration error	17.91	14.29	33	32133	26390	90569891
Cardiac death	17.80	14.29	7	32159	581	90595700
Dehydration	17.72	14.29	124	32042	194323	90401958
Night sweats	17.67	14.29	12	32154	128754	90467527
Anaemia	17.57	14.29	197	31969	352605	90243676
Sciatica	17.54	14.29	7	32159	101375	90494906
Jaundice neonatal	17.20	14.29	8	32158	1002	90595279
Type 1 diabetes mellitus	17.16	14.29	14	32152	4798	90591483
Insulin autoimmune syndrome	17.15	14.29	5	32161	165	90596116
Macular oedema	16.92	14.29	14	32152	4895	90591386
Extradural haematoma	16.85	14.29	10	32156	2058	90594223
Completed suicide	16.81	14.29	16	32150	145042	90451239
Cystoid macular oedema	16.71	14.29	10	32156	2090	90594191
Macrosomia	16.53	14.29	4	32162	63	90596218
Treatment noncompliance	16.51	14.29	48	32118	51679	90544602
Asphyxia	16.09	14.29	16	32150	7087	90589194
Episcleritis	15.95	14.29	8	32158	1182	90595099
Injection site nodule	15.93	14.29	13	32153	4460	90591821
Myocardial infarction	15.81	14.29	77	32089	105895	90490386
Obesity	15.63	14.29	9	32157	105498	90490783
Congenital diaphragmatic hernia	15.49	14.29	5	32161	233	90596048
Pallor	15.31	14.29	36	32130	34129	90562152
Renal failure	15.31	14.29	89	32077	130918	90465363
Diabetic gangrene	15.30	14.29	3	32163	16	90596265
Diabetes mellitus	15.07	14.29	54	32112	64821	90531460
Altered state of consciousness	14.98	14.29	34	32132	31498	90564783
Urogenital haemorrhage	14.92	14.29	5	32161	262	90596019
Diabetic metabolic decompensation	14.75	14.29	9	32157	1948	90594333
Adverse event	14.75	14.29	12	32154	117406	90478875
Vitreous haemorrhage	14.66	14.29	10	32156	2616	90593665
Diabetic ketosis	14.63	14.29	6	32160	555	90595726
Lower limb fracture	14.49	14.29	6	32160	85007	90511274
Drug-induced liver injury	14.42	14.29	7	32159	90311	90505970
Abortion spontaneous	14.31	14.29	47	32119	54009	90542272

FDA Adverse Event Reporting System (Male)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Hypoglycaemia	477.11	13.18	307	18335	59547	42543146
Blood glucose increased	348.35	13.18	275	18367	73424	42529269
Diabetic ketoacidosis	188.42	13.18	119	18523	22248	42580445
Diabetes mellitus inadequate control	166.07	13.18	96	18546	15294	42587399
Blood glucose decreased	133.28	13.18	81	18561	14138	42588555
Blood glucose fluctuation	93.92	13.18	44	18598	4543	42598150
Foetal disorder	78.72	13.18	26	18616	1053	42601640
Hypoglycaemic coma	71.02	13.18	31	18611	2713	42599980
Hypoglycaemic unconsciousness	69.91	13.18	22	18620	762	42601931
Glycosylated haemoglobin increased	69.10	13.18	52	18590	12872	42589821
Neutropenia neonatal	66.45	13.18	22	18620	898	42601795
Premature baby	66.06	13.18	65	18577	23088	42579605
Anti-insulin antibody positive	63.26	13.18	15	18627	172	42602521
Hyperglycaemia	60.83	13.18	87	18555	45772	42556921
Foetal exposure during pregnancy	58.75	13.18	87	18555	47224	42555469
Pancreatic carcinoma metastatic	51.65	13.18	26	18616	3140	42599553
General physical health deterioration	50.40	13.18	163	18479	151083	42451610
Ketoacidosis	41.38	13.18	27	18615	5325	42597368
Blood glucose abnormal	41.35	13.18	30	18612	7023	42595670
Toxicity to various agents	40.66	13.18	25	18617	229111	42373582
Hypoglycaemic seizure	38.89	13.18	12	18630	389	42602304
Low birth weight baby	38.21	13.18	33	18609	9922	42592771
Acute kidney injury	36.58	13.18	280	18362	367057	42235636
Diabetic metabolic decompensation	36.47	13.18	18	18624	2084	42600609
Injection site mass	36.15	13.18	30	18612	8545	42594148
Adenocarcinoma pancreas	35.83	13.18	16	18626	1478	42601215
Injection site pruritus	35.74	13.18	31	18611	9374	42593319
Diabetic neuropathy	35.51	13.18	23	18619	4479	42598214
Drug ineffective	35.42	13.18	149	18493	630048	41972645
Pancreatitis chronic	34.92	13.18	18	18624	2284	42600409
Drug abuse	34.70	13.18	3	18639	104768	42497925
Dehydration	33.76	13.18	137	18505	141630	42461063
Pancreatitis	32.96	13.18	64	18578	43204	42559489
Injection site erythema	32.35	13.18	42	18600	20153	42582540
VACTERL syndrome	32.25	13.18	7	18635	52	42602641
Pancreatic carcinoma	31.50	13.18	29	18613	9477	42593216
Vomiting projectile	30.85	13.18	12	18630	783	42601910
Off label use	29.39	13.18	162	18480	638173	41964520
Product monitoring error	28.66	13.18	20	18622	4403	42598290
Toe amputation	28.24	13.18	17	18625	2912	42599781
Febrile neutropenia	28.05	13.18	24	18618	185679	42417014
Product prescribing error	26.79	13.18	44	18598	26068	42576625
Diabetic gangrene	26.11	13.18	8	18634	253	42602440
Product use in unapproved indication	25.32	13.18	26	18616	184430	42418263
Product quality issue	23.80	13.18	34	18608	17848	42584845
Injection site urticaria	23.58	13.18	16	18626	3367	42599326
Diabetic retinopathy	22.59	13.18	13	18629	2050	42600643
Oedema peripheral	21.69	13.18	117	18525	135959	42466734
Hemivertebra	21.28	13.18	6	18636	141	42602552
Laryngeal leukoplakia	21.28	13.18	5	18637	55	42602638
Hypoglycaemia unawareness	20.93	13.18	6	18636	150	42602543
Diabetic foot	20.16	13.18	14	18628	3059	42599634
Hypoglycaemia neonatal	19.50	13.18	12	18630	2138	42600555
Exposure to communicable disease	19.34	13.18	6	18636	198	42602495
Syncope	18.29	13.18	89	18553	99317	42503376
Infective pulmonary exacerbation of cystic fibrosis	17.01	13.18	19	18623	7799	42594894
Injection site irritation	16.93	13.18	10	18632	1654	42601039
Device failure	16.84	13.18	12	18630	2731	42599962
Anaemia vitamin B12 deficiency	16.68	13.18	7	18635	556	42602137
Injection site rash	16.22	13.18	16	18626	5696	42596997
Insulin-requiring type 2 diabetes mellitus	16.06	13.18	5	18637	167	42602526
Cardiac failure congestive	16.00	13.18	77	18565	85525	42517168
Lack of application site rotation	16.00	13.18	4	18638	58	42602635
Diabetes mellitus	15.84	13.18	60	18582	60027	42542666
Diabetic coma	15.68	13.18	8	18634	993	42601700
Dyspnoea	15.66	13.18	276	18366	442345	42160348
Completed suicide	15.13	13.18	12	18630	96453	42506240
Loss of consciousness	15.10	13.18	80	18562	92274	42510419
Funguria	15.09	13.18	4	18638	74	42602619
Infusion related reaction	15.03	13.18	4	18638	60802	42541891
Diabetic foot infection	14.79	13.18	7	18635	739	42601954
Dizziness	14.65	13.18	170	18472	249084	42353609
Injection site nodule	14.54	13.18	10	18632	2151	42600542
Shock hypoglycaemic	14.52	13.18	4	18638	86	42602607
Insulin resistance	14.22	13.18	7	18635	806	42601887
Musculoskeletal pain	13.96	13.18	39	18603	33301	42569392
Treatment failure	13.90	13.18	5	18637	62619	42540074
Urogenital infection fungal	13.85	13.18	3	18639	22	42602671
Hyperkalaemia	13.36	13.18	70	18572	80388	42522305
Lipohypertrophy	13.29	13.18	5	18637	298	42602395

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Hypoglycaemia	830.17	12.92	533	42515	115571	110430680
Blood glucose increased	662.47	12.92	488	42560	132008	110414243
Diabetic ketoacidosis	501.09	12.92	269	42779	41789	110504462
Gangrene	475.80	12.92	194	42854	16147	110530104
Arterial occlusive disease	426.16	12.92	176	42872	15132	110531119
Carotid artery thrombosis	418.37	12.92	153	42895	9485	110536766
Neurologic neglect syndrome	408.80	12.92	149	42899	9149	110537102
Adjustment disorder	372.90	12.92	145	42903	10650	110535601
Personality disorder	362.11	12.92	149	42899	12688	110533563
Affect lability	324.02	12.92	154	42894	18483	110527768
Sensory loss	318.09	12.92	159	42889	21298	110524953
Skin haemorrhage	296.20	12.92	159	42889	24668	110521583
Hemiplegia	291.85	12.92	153	42895	22629	110523622
Coordination abnormal	288.25	12.92	157	42891	25071	110521180
Motor dysfunction	287.52	12.92	155	42893	24251	110522000
Diabetes mellitus inadequate control	282.41	12.92	164	42884	29611	110516640
Sinus congestion	273.70	12.92	162	42886	30297	110515954
Sneezing	263.82	12.92	161	42887	31823	110514428
Sinus disorder	262.94	12.92	162	42886	32566	110513685
Eating disorder	256.23	12.92	156	42892	30702	110515549
Angina pectoris	252.96	12.92	203	42845	62092	110484159
Respiratory tract congestion	243.48	12.92	151	42897	30706	110515545
Muscle spasticity	229.70	12.92	154	42894	35761	110510490
Cataract	229.25	12.92	213	42835	79272	110466979
Blood glucose decreased	226.86	12.92	142	42906	29346	110516905
Hemiparesis	226.48	12.92	165	42883	43738	110502513
Hyperglycaemia	203.97	12.92	206	42842	84884	110461367
Aphasia	185.55	12.92	166	42882	58831	110487420
Cerebrovascular accident	175.60	12.92	279	42769	181005	110365246
Cystitis	162.15	12.92	162	42886	65874	110480377
Dysarthria	154.66	12.92	177	42871	83944	110462307
Skin exfoliation	153.73	12.92	180	42868	87471	110458780
Blood glucose fluctuation	153.62	12.92	70	42978	7628	110538623
Ketoacidosis	147.27	12.92	74	42974	10013	110536238
Influenza like illness	132.98	12.92	168	42880	88244	110458007
Drug ineffective	130.42	12.92	247	42801	1520293	109025958
Lactic acidosis	129.62	12.92	170	42878	92641	110453610
Rhinorrhoea	128.08	12.92	178	42870	102488	110443763
Chest discomfort	123.06	12.92	233	42815	173615	110372636
Palpitations	120.98	12.92	220	42828	158992	110387259
Hypoglycaemic unconsciousness	120.30	12.92	36	43012	1184	110545067
Glycosylated haemoglobin increased	117.79	12.92	87	42961	23532	110522719
Hypoglycaemic coma	115.75	12.92	52	42996	5481	110540770
Dysphagia	110.11	12.92	207	42841	153393	110392858
Anti-insulin antibody positive	110.04	12.92	25	43023	266	110545985
Acute kidney injury	109.40	12.92	513	42535	634917	109911334
Blood pressure increased	104.57	12.92	277	42771	258096	110288155
Influenza	103.20	12.92	213	42835	168888	110377363
Psoriasis	98.27	12.92	187	42861	139806	110406445
Off label use	97.76	12.92	282	42766	1499903	109046348
Arthritis	94.05	12.92	204	42844	167382	110378869
Infusion related reaction	92.60	12.92	18	43030	381144	110165107
Diabetic retinopathy	89.19	12.92	38	43010	3526	110542725
Drug intolerance	89.18	12.92	24	43024	406488	110139763
Joint swelling	83.41	12.92	34	43014	442811	110103440
Treatment failure	79.22	12.92	8	43040	277226	110269025
Muscular weakness	75.08	12.92	240	42808	248228	110298023
Fall	70.90	12.92	439	42609	603043	109943208
Arthropathy	68.93	12.92	14	43034	287508	110258743
Glossodynia	67.25	12.92	5	43043	221999	110324252
Contraindicated product administered	64.04	12.92	10	43038	248257	110297994
Pericarditis	63.44	12.92	6	43042	219108	110327143
Blood glucose abnormal	63.10	12.92	47	43001	12869	110533382
Alopecia	59.52	12.92	34	43014	364719	110181532
Helicobacter infection	58.37	12.92	3	43045	181874	110364377
Injection site mass	57.86	12.92	59	42989	24554	110521697
Diabetic neuropathy	57.10	12.92	35	43013	6964	110539287
Musculoskeletal stiffness	55.12	12.92	20	43028	279802	110266449
Hepatic enzyme increased	53.67	12.92	29	43019	320863	110225388
Lower respiratory tract infection	52.08	12.92	15	43033	243091	110303160
Vomiting	51.51	12.92	561	42487	910114	109636137
Product use in unapproved indication	51.44	12.92	59	42989	447318	110098933
Infective pulmonary exacerbation of cystic fibrosis	49.28	12.92	43	43005	14728	110531523
Insulin resistance	48.46	12.92	20	43028	1714	110544537
Hypoglycaemic seizure	48.07	12.92	17	43031	955	110545296
Arthralgia	48.05	12.92	150	42898	779482	109766769
Febrile neutropenia	46.90	12.92	33	43015	316734	110229517
Irritable bowel syndrome	46.22	12.92	5	43043	164210	110382041
Pancreatic carcinoma metastatic	45.03	12.92	25	43023	4139	110542112
Injection site pruritus	44.30	12.92	75	42973	51183	110495068
Impaired healing	44.28	12.92	11	43037	196706	110349545
Blood cholesterol increased	44.27	12.92	9	43039	184776	110361475
Therapeutic product effect decreased	43.98	12.92	20	43028	244296	110301955
Diabetic metabolic decompensation	43.84	12.92	24	43024	3865	110542386
Fibromyalgia	43.81	12.92	7	43041	170902	110375349
Adenocarcinoma pancreas	43.34	12.92	20	43028	2243	110544008
Pancreatitis	42.68	12.92	105	42943	93428	110452823
Dehydration	42.44	12.92	218	42830	279293	110266958
Mobility decreased	41.87	12.92	20	43028	237402	110308849
Premature delivery	41.03	12.92	55	42993	30577	110515674
Anaemia vitamin B12 deficiency	40.67	12.92	16	43032	1211	110545040
Infection	40.30	12.92	49	42999	362151	110184100
Sinusitis	40.02	12.92	224	42824	296464	110249787
Injection site urticaria	39.98	12.92	41	43007	17174	110529077
Bursitis	39.12	12.92	3	43045	129915	110416336
Discomfort	37.99	12.92	18	43030	214689	110331562
Anti-insulin antibody	37.04	12.92	8	43040	66	110546185
Rheumatoid arthritis	36.37	12.92	220	42828	299393	110246858
Pancreatitis chronic	35.59	12.92	22	43026	4443	110541808
Hyperkalaemia	35.50	12.92	125	42923	135671	110410580
Cough	35.18	12.92	303	42745	461338	110084913
Ill-defined disorder	34.86	12.92	9	43039	156844	110389407
Sleep disorder	34.62	12.92	17	43031	198627	110347624
Completed suicide	33.62	12.92	27	43021	242354	110303897
Joint range of motion decreased	33.56	12.92	4	43044	121828	110424423
Abdominal discomfort	33.50	12.92	64	42984	393794	110152457
Malaise	33.46	12.92	404	42644	671415	109874836
General physical health deterioration	33.38	12.92	281	42767	425014	110121237
Drug abuse	32.75	12.92	14	43034	177397	110368854
Increased insulin requirement	32.55	12.92	9	43039	222	110546029
Diabetic gangrene	32.17	12.92	9	43039	232	110546019
Injection site erythema	32.16	12.92	95	42953	94081	110452170
Product prescribing error	31.68	12.92	65	42983	51266	110494985
Hypoglycaemia unawareness	31.29	12.92	9	43039	257	110545994
Intentional product use issue	30.35	12.92	31	43017	247875	110298376
Asthenia	30.34	12.92	405	42643	688594	109857657
Pancreatitis acute	30.01	12.92	70	42978	60204	110486047
Euglycaemic diabetic ketoacidosis	29.41	12.92	29	43019	11594	110534657
Confusional state	28.87	12.92	294	42754	468386	110077865
Nausea	28.60	12.92	655	42393	1235035	109311216
Stomatitis	28.55	12.92	38	43010	270204	110276047
Therapeutic product effect incomplete	28.53	12.92	27	43021	223778	110322473
Anti-insulin antibody increased	28.29	12.92	7	43041	110	110546141
Device failure	28.20	12.92	23	43025	7184	110539067
Systemic infection	27.68	12.92	26	43022	9793	110536458
Anxiety	27.59	12.92	229	42819	344849	110201402
Liver injury	27.56	12.92	12	43036	150401	110395850
Osteoarthritis	27.05	12.92	19	43029	182604	110363647
Neutropenia	26.79	12.92	67	42981	374553	110171698
Psoriatic arthropathy	25.96	12.92	23	43025	196738	110349513
C-reactive protein increased	25.83	12.92	28	43020	217891	110328360
Syncope	25.38	12.92	150	42898	202386	110343865
Injection site nodule	25.17	12.92	18	43030	4628	110541623
Toxicity to various agents	25.16	12.92	99	42949	480456	110065795
Inflammation	25.00	12.92	23	43025	193215	110353036
Blood ketone body	24.78	12.92	7	43041	187	110546064
Obesity	24.25	12.92	7	43041	113344	110432907
Swelling	24.16	12.92	64	42984	350977	110195274
Toe amputation	23.95	12.92	17	43031	4321	110541930
Product monitoring error	23.95	12.92	23	43025	8904	110537347
Gastric disorder	23.93	12.92	45	43003	33312	110512939
Therapy non-responder	23.78	12.92	16	43032	157291	110388960
Gastrointestinal disorder	23.47	12.92	168	42880	241784	110304467
Dry mouth	23.36	12.92	26	43022	199922	110346329
Dyspepsia	23.23	12.92	24	43024	190941	110355310
Sciatica	23.19	12.92	4	43044	92395	110453856
Visceral congestion	23.02	12.92	11	43037	1334	110544917
Exposure during pregnancy	22.95	12.92	127	42921	167297	110378954
Anuria	22.89	12.92	37	43011	24304	110521947
Multiple lentigines syndrome	22.86	12.92	7	43041	249	110546002
Diabetic retinal oedema	22.85	12.92	8	43040	436	110545815
Rash	22.83	12.92	207	42841	820757	109725494
Pre-eclampsia	22.67	12.92	22	43026	8628	110537623
Injection site rash	22.57	12.92	36	43012	23383	110522868
Diabetic foot	22.50	12.92	16	43032	4079	110542172
Injury	21.88	12.92	22	43026	177243	110369008
Type 2 diabetes mellitus	21.87	12.92	22	43026	177210	110369041
Laryngeal leukoplakia	21.77	12.92	5	43043	56	110546195
Chronic kidney disease	21.48	12.92	72	42976	76219	110470032
Diabetes mellitus	20.62	12.92	85	42963	99296	110446955
Anaemia	20.61	12.92	313	42735	546773	109999478
Gestational hypertension	20.37	12.92	12	43036	2222	110544029
Blister	20.16	12.92	36	43012	227340	110318911
Type 1 diabetes mellitus	20.02	12.92	21	43027	9026	110537225
Vomiting projectile	19.96	12.92	12	43036	2306	110543945
Injection site irritation	19.87	12.92	16	43032	4908	110541343
Diabetic coma	19.86	12.92	10	43038	1358	110544893
Metabolic acidosis	19.67	12.92	84	42964	99660	110446591
Grip strength decreased	19	12.92	4	43044	80170	110466081
Rhonchi	18.91	12.92	15	43033	4503	110541748
Insulin autoimmune syndrome	18.86	12.92	8	43040	734	110545517
Hypersensitivity	18.81	12.92	87	42961	403911	110142340
Delirium	18.77	12.92	15	43033	135010	110411241
Hypercholesterolaemia	18.73	12.92	6	43042	90831	110455420
Upper respiratory tract irritation	18.69	12.92	6	43042	250	110546001
Asthma	18.49	12.92	44	43004	250247	110296004
Night sweats	18.48	12.92	15	43033	133968	110412283
Product dispensing error	18.39	12.92	27	43021	16318	110529933
Peripheral venous disease	18.36	12.92	5	43043	84112	110462139
Loss of personal independence in daily activities	18.08	12.92	19	43029	150001	110396250
Pancreatic carcinoma	17.37	12.92	25	43023	14847	110531404
Product administration error	17.20	12.92	42	43006	37175	110509076
Gait inability	16.74	12.92	17	43031	136359	110409892
Drug hypersensitivity	16.62	12.92	106	42942	453984	110092267
Cardiac failure congestive	16.51	12.92	108	42940	150892	110395359
Insulin-requiring type 2 diabetes mellitus	16.20	12.92	5	43043	183	110546068
Lack of application site rotation	15.82	12.92	4	43044	69	110546182
Product use issue	15.80	12.92	65	42983	311630	110234621
Wound infection	15.70	12.92	9	43039	96456	110449795
Myocardial infarction	15.62	12.92	128	42920	191955	110354296
Cellulitis	15.57	12.92	93	42955	125923	110420328
Diabetic nephropathy	15.45	12.92	12	43036	3496	110542755
Nasopharyngitis	15.37	12.92	227	42821	394134	110152117
Contusion	14.97	12.92	44	43004	233317	110312934
Duodenal neoplasm	14.94	12.92	4	43044	87	110546164
Nonreassuring foetal heart rate pattern	14.87	12.92	3	43045	17	110546234
Cataract subcapsular	14.82	12.92	8	43040	1253	110544998
Episcleritis	14.79	12.92	8	43040	1258	110544993
Acute myocardial infarction	14.60	12.92	68	42980	83709	110462542
Accidental underdose	14.56	12.92	8	43040	1297	110544954
Migraine	14.48	12.92	28	43020	171624	110374627
Injection site hypersensitivity	14.38	12.92	10	43038	2461	110543790
Blood insulin decreased	14.33	12.92	3	43045	21	110546230
Taste disorder	14.06	12.92	4	43044	65383	110480868
Diabetic ketosis	14.05	12.92	7	43041	929	110545322
Cyanopsia	13.98	12.92	4	43044	112	110546139
Knee arthroplasty	13.91	12.92	4	43044	64944	110481307
Cytokine release syndrome	13.87	12.92	5	43043	70301	110475950
Pneumonia	13.71	12.92	442	42606	876272	109669979
Hypertension	13.55	12.92	130	42918	509954	110036297
White blood cell count decreased	13.48	12.92	45	43003	229345	110316906
Macular oedema	13.37	12.92	15	43033	6951	110539300
Treatment noncompliance	13.28	12.92	60	42988	72930	110473321
Paraesthesia	13.19	12.92	59	42989	276462	110269789
Prescribed overdose	13.11	12.92	9	43039	87572	110458679
Wound	13.09	12.92	47	43001	234390	110311861
Decreased insulin requirement	12.94	12.92	4	43044	147	110546104

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

Source	Code	Description
ATC	A10AE05	ALIMENTARY TRACT AND METABOLISM DRUGS USED IN DIABETES INSULINS AND ANALOGUES Insulins and analogues for injection, long-acting
FDA CS	M0011417	Insulin
FDA Chemical/Ingredient	N0000004931	Insulin
FDA EPC	N0000175453	Insulin Analog
MeSH PA	D007004	Hypoglycemic Agents
FDA EPC	N0000175944	Insulin
CHEBI has role	CHEBI:22587	antiviral agent
CHEBI has role	CHEBI:35469	antidepressant
CHEBI has role	CHEBI:35476	antipsychotic agent
CHEBI has role	CHEBI:35480	analgesic
CHEBI has role	CHEBI:35526	hypoglycemic agent
CHEBI has role	CHEBI:35554	cardiovascular drug
CHEBI has role	CHEBI:35674	antihypertensive agent
CHEBI has role	CHEBI:35705	immunosuppressive agent
CHEBI has role	CHEBI:35821	anticholesteremic drug
CHEBI has role	CHEBI:39456	antiglaucoma drug
CHEBI has role	CHEBI:48407	antiparkinson drug
CHEBI has role	CHEBI:50864	insulin-sensitizing drug
CHEBI has role	CHEBI:66981	ophthalmology drug
CHEBI has role	CHEBI:73336	vulnerary
CHEBI has role	CHEBI:74518	anti-obesity agent
CHEBI has role	CHEBI:76916	hyperglycemic agent
CHEBI has role	CHEBI:145947	antiatherosclerotic agent
CHEBI has role	CHEBI:231911	renoprotective agent

Related Drugs by ATC class:

A10AE Insulins and analogues for injection, long-acting 9 drugs

insulin beefinsulin degludecinsulin glargineinsulin humaninsulin icodecinsulin porkliraglutidelixisenatidesemaglutide

Drug Use | Suggest Off label Use Form| |View source of the data|

Disease	Relation	SNOMED_ID	DOID
Diabetes mellitus	indication	73211009	DOID:9351

🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

None

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

Target	Class	Pharos	UniProt	Action	Type	Activity value (-log[M])	Mechanism action	Bioact source	MoA source
Insulin receptor	Kinase	P06213	INSR_HUMAN	AGONIST				DRUG LABEL	DRUG LABEL

External reference:

ID	Source
D04539	KEGG_DRUG
4017559	VANDF
4017569	VANDF
4019786	VANDF
CHEBI:750813	CHEBI
CHEMBL2104391	ChEMBL_ID
DB01307	DRUGBANK_ID
139825	RXNORM
19234	MMSL
4885	MMSL
4886	MMSL
72333	MMSL
d00262	MMSL
d04369	MMSL
d05436	MMSL
000869	NDDF
000870	NDDF
006518	NDDF
010059	NDDF
126210001	SNOMEDCT_US
414515005	SNOMEDCT_US
414518007	SNOMEDCT_US
417423002	SNOMEDCT_US
420609005	SNOMEDCT_US
96367001	SNOMEDCT_US
C0537270	UMLSCUI
D000069057	MESH_DESCRIPTOR_UI
C0795635	UMLSCUI
DB00030	DRUGBANK_ID
7735	INN_ID
16137271	PUBCHEM_CID
118984375	PUBCHEM_CID
4FT78T86XV	UNII
5186	INN_ID
CHEBI:5931	CHEBI
4FT78T86XV	INXIGHT DRUGS

Pharmaceutical products:

Product	Category	Ingredients	NDC	Form	Quantity	Route	Marketing	Label
Levemir	HUMAN PRESCRIPTION DRUG LABEL	1	0169-3687	INJECTION, SOLUTION	100 [iU]	SUBCUTANEOUS	BLA	26 sections
Levemir	HUMAN PRESCRIPTION DRUG LABEL	1	0169-6432	INJECTION, SOLUTION	100 [iU]	SUBCUTANEOUS	BLA	26 sections
Levemir	HUMAN PRESCRIPTION DRUG LABEL	1	0169-6438	INJECTION, SOLUTION	100 [iU]	SUBCUTANEOUS	BLA	26 sections
Levemir	HUMAN PRESCRIPTION DRUG LABEL	1	50090-1276	INJECTION, SOLUTION	100 [iU]	SUBCUTANEOUS	BLA	26 sections
Levemir	HUMAN PRESCRIPTION DRUG LABEL	1	50090-1475	INJECTION, SOLUTION	100 [iU]	SUBCUTANEOUS	BLA	26 sections
Levemir	HUMAN PRESCRIPTION DRUG LABEL	1	54868-5883	INJECTION, SOLUTION	14.20 mg	SUBCUTANEOUS	NDA	26 sections
Levemir	HUMAN PRESCRIPTION DRUG LABEL	1	68258-8977	IMPLANT	14.20 mg	SOFT TISSUE	NDA	26 sections