insulin detemir 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | PK/Tox | Related Drugs | BioActivity |

Stem definitionDrug idCAS RN
4985 169148-63-4

Description:

MoleculeDescription

Synonyms:

  • insulin detemir
  • levemir
  • insulin detemir recombinant
  • insulin detemir [rDNA origin]
  • NN304
  • NN 304
  • NN-304
A recombinant long-acting insulin and hypoglycemic agent in which a MYRISTIC ACID is conjugated to a LYSINE at position B29. It is used to manage BLOOD GLUCOSE levels in patients with DIABETES MELLITUS.
  • Molecular weight: 5916.89
  • Formula: C267H402N64O76S6
  • CLOGP:
  • LIPINSKI: None
  • HAC: None
  • HDO: None
  • TPSA: 2252.82
  • ALOGS:
  • ROTB: None

Drug dosage:

DoseUnitRoute
40 U P

ADMET properties:

None

Predicted pharmacokinetic/toxicological properties (PK-AZ):

None

Approvals:

DateAgencyCompanyOrphan
June 16, 2005 FDA NOVO NORDISK INC
June 1, 2004 EMA

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Blood glucose increased 715.20 14.29 436 31730 94810 90501471
Hypoglycaemia 542.71 14.29 327 31839 69521 90526760
Gangrene 501.03 14.29 184 31982 12692 90583589
Arterial occlusive disease 466.38 14.29 173 31993 12273 90584008
Carotid artery thrombosis 425.59 14.29 149 32017 8943 90587338
Neurologic neglect syndrome 418.01 14.29 146 32020 8701 90587580
Diabetic ketoacidosis 415.20 14.29 193 31973 24214 90572067
Adjustment disorder 390.75 14.29 142 32024 9500 90586781
Personality disorder 369.47 14.29 146 32020 12298 90583983
Sensory loss 342.21 14.29 154 32012 17921 90578360
Hemiplegia 335.88 14.29 147 32019 16013 90580268
Affect lability 326.47 14.29 149 32017 17914 90578367
Motor dysfunction 317.56 14.29 149 32017 19081 90577200
Coordination abnormal 314.67 14.29 153 32013 21203 90575078
Skin haemorrhage 314.51 14.29 153 32013 21227 90575054
Angina pectoris 313.44 14.29 187 31979 38973 90557308
Sinus congestion 292.43 14.29 158 32008 27266 90569015
Sneezing 274.40 14.29 156 32010 29713 90566568
Eating disorder 267.02 14.29 150 32016 27923 90568358
Respiratory tract congestion 264.91 14.29 148 32018 27262 90569019
Sinus disorder 261.45 14.29 159 32007 34288 90561993
Hemiparesis 254.75 14.29 152 32014 31667 90564614
Aphasia 234.56 14.29 161 32005 42651 90553630
Cataract 233.19 14.29 198 31968 71894 90524387
Muscle spasticity 232.65 14.29 149 32017 35173 90561108
Cerebrovascular accident 227.97 14.29 249 31917 123284 90472997
Blood glucose decreased 216.89 14.29 123 32043 23306 90572975
Dysarthria 210.57 14.29 166 32000 54316 90541965
Hyperglycaemia 194.18 14.29 154 32012 50816 90545465
Skin exfoliation 186.52 14.29 170 31996 67743 90528538
Diabetes mellitus inadequate control 183.56 14.29 102 32064 18582 90577699
Cystitis 179.31 14.29 165 32001 66553 90529728
Palpitations 155.48 14.29 216 31950 136512 90459769
Lactic acidosis 153.79 14.29 134 32032 50329 90545952
Influenza like illness 153.01 14.29 165 32001 80446 90515835
Rhinorrhoea 147.38 14.29 169 31997 88147 90508134
Chest discomfort 146.12 14.29 211 31955 138154 90458127
Blood pressure increased 132.41 14.29 245 31921 196972 90399309
Glycosylated haemoglobin increased 128.85 14.29 76 32090 15486 90580795
Blood glucose fluctuation 128.00 14.29 53 32113 5030 90591251
Dysphagia 122.60 14.29 174 31992 112104 90484177
Drug ineffective 122.23 14.29 190 31976 1384108 89212173
Ketoacidosis 119.82 14.29 52 32114 5543 90590738
Influenza 119.65 14.29 193 31973 139071 90457210
Drug intolerance 116.20 14.29 12 32154 447579 90148702
Arthritis 101.34 14.29 199 31967 167116 90429165
Glossodynia 100.48 14.29 3 32163 321776 90274505
Contraindicated product administered 99.91 14.29 3 32163 320136 90276145
Psoriasis 99.68 14.29 184 31982 147570 90448711
Infusion related reaction 96.61 14.29 16 32150 416764 90179517
Alopecia 94.80 14.29 29 32137 495042 90101239
Treatment failure 94.30 14.29 3 32163 303925 90292356
Fall 92.71 14.29 377 31789 481433 90114848
Hypoglycaemic unconsciousness 91.29 14.29 26 32140 788 90595493
Joint swelling 88.55 14.29 34 32132 503266 90093015
Arthropathy 82.80 14.29 15 32151 366227 90230054
Pericarditis 82.62 14.29 3 32163 270148 90326133
Premature delivery 80.01 14.29 83 32083 38679 90557602
Diabetic retinopathy 77.72 14.29 31 32135 2671 90593610
Hypoglycaemic coma 74.69 14.29 31 32135 2959 90593322
Acute kidney injury 74.13 14.29 266 31900 320121 90276160
Hepatic enzyme increased 72.97 14.29 19 32147 360717 90235564
Muscular weakness 66.32 14.29 192 31974 206474 90389807
Duodenal ulcer perforation 65.83 14.29 3 32163 221285 90374996
Off label use 62.46 14.29 193 31973 1102059 89494222
Anti-insulin antibody positive 62.08 14.29 13 32153 101 90596180
Insulin resistance 62.03 14.29 21 32145 1137 90595144
Impaired healing 61.44 14.29 6 32160 234193 90362088
Musculoskeletal stiffness 61.15 14.29 15 32151 296517 90299764
Irritable bowel syndrome 58.05 14.29 4 32162 207444 90388837
Blood glucose abnormal 57.46 14.29 38 32128 9454 90586827
Therapeutic product effect decreased 57.31 14.29 14 32152 277557 90318724
Injection site mass 56.16 14.29 53 32113 22037 90574244
Arthralgia 53.32 14.29 124 32042 778398 89817883
Lower respiratory tract infection 53.02 14.29 12 32154 250647 90345634
Abdominal discomfort 52.74 14.29 55 32111 477273 90119008
Discomfort 52.58 14.29 16 32150 274319 90321962
Vomiting 51.04 14.29 464 31702 787829 89808452
Exposure during pregnancy 49.29 14.29 191 31975 238219 90358062
Stomatitis 49.19 14.29 18 32148 274680 90321601
Foetal exposure during pregnancy 48.94 14.29 68 32098 42907 90553374
Liver injury 48.58 14.29 3 32163 170564 90425717
Cough 47.48 14.29 257 31909 368705 90227576
Systemic infection 46.70 14.29 26 32140 4749 90591532
Infection 44.34 14.29 38 32128 362056 90234225
Hypoglycaemia neonatal 43.50 14.29 16 32150 1106 90595175
Mobility decreased 42.30 14.29 18 32148 250716 90345565
Anxiety 41.35 14.29 218 31948 309554 90286727
Blood cholesterol increased 40.09 14.29 12 32154 208000 90388281
Fibromyalgia 39.57 14.29 12 32154 206257 90390024
Infective pulmonary exacerbation of cystic fibrosis 38.99 14.29 31 32135 10248 90586033
Injury 38.73 14.29 11 32155 197338 90398943
Injection site urticaria 37.94 14.29 39 32127 17972 90578309
C-reactive protein increased 37.72 14.29 9 32157 181380 90414901
Therapeutic product effect incomplete 37.70 14.29 11 32155 193885 90402396
Injection site pruritus 37.47 14.29 68 32098 53766 90542515
Visceral congestion 37.27 14.29 11 32155 379 90595902
Pre-eclampsia 37.03 14.29 31 32135 11017 90585264
Ill-defined disorder 36.86 14.29 10 32156 184881 90411400
Psoriatic arthropathy 36.02 14.29 18 32148 228317 90367964
Sleep disorder 33.75 14.29 14 32152 198016 90398265
Hypoglycaemic seizure 33.35 14.29 11 32155 549 90595732
Wound 32.22 14.29 36 32130 302944 90293337
Joint range of motion decreased 31.85 14.29 5 32161 135638 90460643
Asthenia 31.85 14.29 309 31857 533442 90062839
Pancreatitis 31.77 14.29 74 32092 69752 90526529
Swelling 31.73 14.29 63 32103 418995 90177286
Injection site erythema 31.06 14.29 91 32075 98411 90497870
Anuria 31.05 14.29 32 32134 14786 90581495
Blister 30.91 14.29 27 32139 254971 90341310
Sinusitis 30.87 14.29 218 31948 342870 90253411
Increased insulin requirement 30.84 14.29 7 32159 82 90596199
Rash 30.67 14.29 162 32004 795938 89800343
Hypersensitivity 30.59 14.29 73 32093 454604 90141677
Malaise 30.56 14.29 330 31836 585656 90010625
Hyperkalaemia 29.72 14.29 69 32097 64895 90531386
Diabetic neuropathy 29.37 14.29 19 32147 4555 90591726
Drug hypersensitivity 29.19 14.29 77 32089 463532 90132749
Nausea 29.18 14.29 554 31612 1109762 89486519
Osteoarthritis 28.58 14.29 17 32149 195713 90400568
Product use issue 28.19 14.29 46 32120 329873 90266408
Product use in unapproved indication 26.80 14.29 49 32117 336187 90260094
Confusional state 26.77 14.29 231 31935 385974 90210307
Premature baby 26.07 14.29 38 32128 25039 90571242
Blood ketone body 26.00 14.29 6 32160 76 90596205
Type 2 diabetes mellitus 25.26 14.29 21 32145 203223 90393058
Dyspepsia 25.22 14.29 20 32146 198140 90398141
Anti-insulin antibody 25.00 14.29 5 32161 30 90596251
Multiple lentigines syndrome 24.71 14.29 7 32159 208 90596073
Pneumonia 24.42 14.29 339 31827 637720 89958561
Febrile neutropenia 24.20 14.29 13 32153 158336 90437945
Euglycaemic diabetic ketoacidosis 24.16 14.29 19 32147 6182 90590099
Diabetic retinal oedema 23.98 14.29 8 32158 414 90595867
Anaemia vitamin B12 deficiency 23.92 14.29 9 32157 663 90595618
Dextrocardia 23.75 14.29 5 32161 40 90596241
Hypoglycaemia unawareness 23.44 14.29 6 32160 120 90596161
Rhonchi 23.23 14.29 14 32152 2964 90593317
Anti-insulin antibody increased 23.13 14.29 5 32161 46 90596235
Rheumatoid arthritis 23.12 14.29 213 31953 362401 90233880
Pulmonary fibrosis 23.01 14.29 5 32161 107498 90488783
Gestational hypertension 22.87 14.29 14 32152 3048 90593233
Peripheral swelling 22.80 14.29 73 32093 413033 90183248
Inflammation 22.76 14.29 18 32148 178574 90417707
Wound infection 22.67 14.29 5 32161 106397 90489884
Neutropenia 22.53 14.29 28 32138 224876 90371405
Gait inability 22.41 14.29 12 32154 146444 90449837
Intentional product use issue 21.73 14.29 27 32139 216865 90379416
Dry mouth 21.69 14.29 20 32146 184039 90412242
Injection site rash 21.41 14.29 34 32132 24139 90572142
Gastrointestinal disorder 21.29 14.29 160 32006 256527 90339754
Neonatal anoxia 20.83 14.29 3 32163 0 90596281
Contusion 20.56 14.29 36 32130 251180 90345101
Grip strength decreased 20.45 14.29 4 32162 92572 90503709
Pancreatitis acute 20.38 14.29 39 32127 32076 90564205
Blood insulin decreased 20.30 14.29 4 32162 22 90596259
Upper respiratory tract irritation 20.27 14.29 6 32160 209 90596072
Prescribed overdose 19.98 14.29 5 32161 97620 90498661
Peripheral venous disease 19.91 14.29 3 32163 83918 90512363
Therapy non-responder 19.78 14.29 12 32154 136692 90459589
Cataract subcapsular 19.69 14.29 8 32158 723 90595558
Knee arthroplasty 19.67 14.29 3 32163 83179 90513102
Red blood cell sedimentation rate increased 19.49 14.29 3 32163 82592 90513689
Acute myocardial infarction 19.30 14.29 40 32126 34850 90561431
Migraine 18.76 14.29 24 32142 190368 90405913
Diabetic nephropathy 18.50 14.29 10 32156 1724 90594557
Hypertension 18.19 14.29 92 32074 457440 90138841
Gastric disorder 18.14 14.29 38 32128 33346 90562935
Product administration error 17.91 14.29 33 32133 26390 90569891
Cardiac death 17.80 14.29 7 32159 581 90595700
Dehydration 17.72 14.29 124 32042 194323 90401958
Night sweats 17.67 14.29 12 32154 128754 90467527
Anaemia 17.57 14.29 197 31969 352605 90243676
Sciatica 17.54 14.29 7 32159 101375 90494906
Jaundice neonatal 17.20 14.29 8 32158 1002 90595279
Type 1 diabetes mellitus 17.16 14.29 14 32152 4798 90591483
Insulin autoimmune syndrome 17.15 14.29 5 32161 165 90596116
Macular oedema 16.92 14.29 14 32152 4895 90591386
Extradural haematoma 16.85 14.29 10 32156 2058 90594223
Completed suicide 16.81 14.29 16 32150 145042 90451239
Cystoid macular oedema 16.71 14.29 10 32156 2090 90594191
Macrosomia 16.53 14.29 4 32162 63 90596218
Treatment noncompliance 16.51 14.29 48 32118 51679 90544602
Asphyxia 16.09 14.29 16 32150 7087 90589194
Episcleritis 15.95 14.29 8 32158 1182 90595099
Injection site nodule 15.93 14.29 13 32153 4460 90591821
Myocardial infarction 15.81 14.29 77 32089 105895 90490386
Obesity 15.63 14.29 9 32157 105498 90490783
Congenital diaphragmatic hernia 15.49 14.29 5 32161 233 90596048
Pallor 15.31 14.29 36 32130 34129 90562152
Renal failure 15.31 14.29 89 32077 130918 90465363
Diabetic gangrene 15.30 14.29 3 32163 16 90596265
Diabetes mellitus 15.07 14.29 54 32112 64821 90531460
Altered state of consciousness 14.98 14.29 34 32132 31498 90564783
Urogenital haemorrhage 14.92 14.29 5 32161 262 90596019
Diabetic metabolic decompensation 14.75 14.29 9 32157 1948 90594333
Adverse event 14.75 14.29 12 32154 117406 90478875
Vitreous haemorrhage 14.66 14.29 10 32156 2616 90593665
Diabetic ketosis 14.63 14.29 6 32160 555 90595726
Lower limb fracture 14.49 14.29 6 32160 85007 90511274
Drug-induced liver injury 14.42 14.29 7 32159 90311 90505970
Abortion spontaneous 14.31 14.29 47 32119 54009 90542272

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Hypoglycaemia 477.11 13.18 307 18335 59547 42543146
Blood glucose increased 348.35 13.18 275 18367 73424 42529269
Diabetic ketoacidosis 188.42 13.18 119 18523 22248 42580445
Diabetes mellitus inadequate control 166.07 13.18 96 18546 15294 42587399
Blood glucose decreased 133.28 13.18 81 18561 14138 42588555
Blood glucose fluctuation 93.92 13.18 44 18598 4543 42598150
Foetal disorder 78.72 13.18 26 18616 1053 42601640
Hypoglycaemic coma 71.02 13.18 31 18611 2713 42599980
Hypoglycaemic unconsciousness 69.91 13.18 22 18620 762 42601931
Glycosylated haemoglobin increased 69.10 13.18 52 18590 12872 42589821
Neutropenia neonatal 66.45 13.18 22 18620 898 42601795
Premature baby 66.06 13.18 65 18577 23088 42579605
Anti-insulin antibody positive 63.26 13.18 15 18627 172 42602521
Hyperglycaemia 60.83 13.18 87 18555 45772 42556921
Foetal exposure during pregnancy 58.75 13.18 87 18555 47224 42555469
Pancreatic carcinoma metastatic 51.65 13.18 26 18616 3140 42599553
General physical health deterioration 50.40 13.18 163 18479 151083 42451610
Ketoacidosis 41.38 13.18 27 18615 5325 42597368
Blood glucose abnormal 41.35 13.18 30 18612 7023 42595670
Toxicity to various agents 40.66 13.18 25 18617 229111 42373582
Hypoglycaemic seizure 38.89 13.18 12 18630 389 42602304
Low birth weight baby 38.21 13.18 33 18609 9922 42592771
Acute kidney injury 36.58 13.18 280 18362 367057 42235636
Diabetic metabolic decompensation 36.47 13.18 18 18624 2084 42600609
Injection site mass 36.15 13.18 30 18612 8545 42594148
Adenocarcinoma pancreas 35.83 13.18 16 18626 1478 42601215
Injection site pruritus 35.74 13.18 31 18611 9374 42593319
Diabetic neuropathy 35.51 13.18 23 18619 4479 42598214
Drug ineffective 35.42 13.18 149 18493 630048 41972645
Pancreatitis chronic 34.92 13.18 18 18624 2284 42600409
Drug abuse 34.70 13.18 3 18639 104768 42497925
Dehydration 33.76 13.18 137 18505 141630 42461063
Pancreatitis 32.96 13.18 64 18578 43204 42559489
Injection site erythema 32.35 13.18 42 18600 20153 42582540
VACTERL syndrome 32.25 13.18 7 18635 52 42602641
Pancreatic carcinoma 31.50 13.18 29 18613 9477 42593216
Vomiting projectile 30.85 13.18 12 18630 783 42601910
Off label use 29.39 13.18 162 18480 638173 41964520
Product monitoring error 28.66 13.18 20 18622 4403 42598290
Toe amputation 28.24 13.18 17 18625 2912 42599781
Febrile neutropenia 28.05 13.18 24 18618 185679 42417014
Product prescribing error 26.79 13.18 44 18598 26068 42576625
Diabetic gangrene 26.11 13.18 8 18634 253 42602440
Product use in unapproved indication 25.32 13.18 26 18616 184430 42418263
Product quality issue 23.80 13.18 34 18608 17848 42584845
Injection site urticaria 23.58 13.18 16 18626 3367 42599326
Diabetic retinopathy 22.59 13.18 13 18629 2050 42600643
Oedema peripheral 21.69 13.18 117 18525 135959 42466734
Hemivertebra 21.28 13.18 6 18636 141 42602552
Laryngeal leukoplakia 21.28 13.18 5 18637 55 42602638
Hypoglycaemia unawareness 20.93 13.18 6 18636 150 42602543
Diabetic foot 20.16 13.18 14 18628 3059 42599634
Hypoglycaemia neonatal 19.50 13.18 12 18630 2138 42600555
Exposure to communicable disease 19.34 13.18 6 18636 198 42602495
Syncope 18.29 13.18 89 18553 99317 42503376
Infective pulmonary exacerbation of cystic fibrosis 17.01 13.18 19 18623 7799 42594894
Injection site irritation 16.93 13.18 10 18632 1654 42601039
Device failure 16.84 13.18 12 18630 2731 42599962
Anaemia vitamin B12 deficiency 16.68 13.18 7 18635 556 42602137
Injection site rash 16.22 13.18 16 18626 5696 42596997
Insulin-requiring type 2 diabetes mellitus 16.06 13.18 5 18637 167 42602526
Cardiac failure congestive 16.00 13.18 77 18565 85525 42517168
Lack of application site rotation 16.00 13.18 4 18638 58 42602635
Diabetes mellitus 15.84 13.18 60 18582 60027 42542666
Diabetic coma 15.68 13.18 8 18634 993 42601700
Dyspnoea 15.66 13.18 276 18366 442345 42160348
Completed suicide 15.13 13.18 12 18630 96453 42506240
Loss of consciousness 15.10 13.18 80 18562 92274 42510419
Funguria 15.09 13.18 4 18638 74 42602619
Infusion related reaction 15.03 13.18 4 18638 60802 42541891
Diabetic foot infection 14.79 13.18 7 18635 739 42601954
Dizziness 14.65 13.18 170 18472 249084 42353609
Injection site nodule 14.54 13.18 10 18632 2151 42600542
Shock hypoglycaemic 14.52 13.18 4 18638 86 42602607
Insulin resistance 14.22 13.18 7 18635 806 42601887
Musculoskeletal pain 13.96 13.18 39 18603 33301 42569392
Treatment failure 13.90 13.18 5 18637 62619 42540074
Urogenital infection fungal 13.85 13.18 3 18639 22 42602671
Hyperkalaemia 13.36 13.18 70 18572 80388 42522305
Lipohypertrophy 13.29 13.18 5 18637 298 42602395

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Hypoglycaemia 830.17 12.92 533 42515 115571 110430680
Blood glucose increased 662.47 12.92 488 42560 132008 110414243
Diabetic ketoacidosis 501.09 12.92 269 42779 41789 110504462
Gangrene 475.80 12.92 194 42854 16147 110530104
Arterial occlusive disease 426.16 12.92 176 42872 15132 110531119
Carotid artery thrombosis 418.37 12.92 153 42895 9485 110536766
Neurologic neglect syndrome 408.80 12.92 149 42899 9149 110537102
Adjustment disorder 372.90 12.92 145 42903 10650 110535601
Personality disorder 362.11 12.92 149 42899 12688 110533563
Affect lability 324.02 12.92 154 42894 18483 110527768
Sensory loss 318.09 12.92 159 42889 21298 110524953
Skin haemorrhage 296.20 12.92 159 42889 24668 110521583
Hemiplegia 291.85 12.92 153 42895 22629 110523622
Coordination abnormal 288.25 12.92 157 42891 25071 110521180
Motor dysfunction 287.52 12.92 155 42893 24251 110522000
Diabetes mellitus inadequate control 282.41 12.92 164 42884 29611 110516640
Sinus congestion 273.70 12.92 162 42886 30297 110515954
Sneezing 263.82 12.92 161 42887 31823 110514428
Sinus disorder 262.94 12.92 162 42886 32566 110513685
Eating disorder 256.23 12.92 156 42892 30702 110515549
Angina pectoris 252.96 12.92 203 42845 62092 110484159
Respiratory tract congestion 243.48 12.92 151 42897 30706 110515545
Muscle spasticity 229.70 12.92 154 42894 35761 110510490
Cataract 229.25 12.92 213 42835 79272 110466979
Blood glucose decreased 226.86 12.92 142 42906 29346 110516905
Hemiparesis 226.48 12.92 165 42883 43738 110502513
Hyperglycaemia 203.97 12.92 206 42842 84884 110461367
Aphasia 185.55 12.92 166 42882 58831 110487420
Cerebrovascular accident 175.60 12.92 279 42769 181005 110365246
Cystitis 162.15 12.92 162 42886 65874 110480377
Dysarthria 154.66 12.92 177 42871 83944 110462307
Skin exfoliation 153.73 12.92 180 42868 87471 110458780
Blood glucose fluctuation 153.62 12.92 70 42978 7628 110538623
Ketoacidosis 147.27 12.92 74 42974 10013 110536238
Influenza like illness 132.98 12.92 168 42880 88244 110458007
Drug ineffective 130.42 12.92 247 42801 1520293 109025958
Lactic acidosis 129.62 12.92 170 42878 92641 110453610
Rhinorrhoea 128.08 12.92 178 42870 102488 110443763
Chest discomfort 123.06 12.92 233 42815 173615 110372636
Palpitations 120.98 12.92 220 42828 158992 110387259
Hypoglycaemic unconsciousness 120.30 12.92 36 43012 1184 110545067
Glycosylated haemoglobin increased 117.79 12.92 87 42961 23532 110522719
Hypoglycaemic coma 115.75 12.92 52 42996 5481 110540770
Dysphagia 110.11 12.92 207 42841 153393 110392858
Anti-insulin antibody positive 110.04 12.92 25 43023 266 110545985
Acute kidney injury 109.40 12.92 513 42535 634917 109911334
Blood pressure increased 104.57 12.92 277 42771 258096 110288155
Influenza 103.20 12.92 213 42835 168888 110377363
Psoriasis 98.27 12.92 187 42861 139806 110406445
Off label use 97.76 12.92 282 42766 1499903 109046348
Arthritis 94.05 12.92 204 42844 167382 110378869
Infusion related reaction 92.60 12.92 18 43030 381144 110165107
Diabetic retinopathy 89.19 12.92 38 43010 3526 110542725
Drug intolerance 89.18 12.92 24 43024 406488 110139763
Joint swelling 83.41 12.92 34 43014 442811 110103440
Treatment failure 79.22 12.92 8 43040 277226 110269025
Muscular weakness 75.08 12.92 240 42808 248228 110298023
Fall 70.90 12.92 439 42609 603043 109943208
Arthropathy 68.93 12.92 14 43034 287508 110258743
Glossodynia 67.25 12.92 5 43043 221999 110324252
Contraindicated product administered 64.04 12.92 10 43038 248257 110297994
Pericarditis 63.44 12.92 6 43042 219108 110327143
Blood glucose abnormal 63.10 12.92 47 43001 12869 110533382
Alopecia 59.52 12.92 34 43014 364719 110181532
Helicobacter infection 58.37 12.92 3 43045 181874 110364377
Injection site mass 57.86 12.92 59 42989 24554 110521697
Diabetic neuropathy 57.10 12.92 35 43013 6964 110539287
Musculoskeletal stiffness 55.12 12.92 20 43028 279802 110266449
Hepatic enzyme increased 53.67 12.92 29 43019 320863 110225388
Lower respiratory tract infection 52.08 12.92 15 43033 243091 110303160
Vomiting 51.51 12.92 561 42487 910114 109636137
Product use in unapproved indication 51.44 12.92 59 42989 447318 110098933
Infective pulmonary exacerbation of cystic fibrosis 49.28 12.92 43 43005 14728 110531523
Insulin resistance 48.46 12.92 20 43028 1714 110544537
Hypoglycaemic seizure 48.07 12.92 17 43031 955 110545296
Arthralgia 48.05 12.92 150 42898 779482 109766769
Febrile neutropenia 46.90 12.92 33 43015 316734 110229517
Irritable bowel syndrome 46.22 12.92 5 43043 164210 110382041
Pancreatic carcinoma metastatic 45.03 12.92 25 43023 4139 110542112
Injection site pruritus 44.30 12.92 75 42973 51183 110495068
Impaired healing 44.28 12.92 11 43037 196706 110349545
Blood cholesterol increased 44.27 12.92 9 43039 184776 110361475
Therapeutic product effect decreased 43.98 12.92 20 43028 244296 110301955
Diabetic metabolic decompensation 43.84 12.92 24 43024 3865 110542386
Fibromyalgia 43.81 12.92 7 43041 170902 110375349
Adenocarcinoma pancreas 43.34 12.92 20 43028 2243 110544008
Pancreatitis 42.68 12.92 105 42943 93428 110452823
Dehydration 42.44 12.92 218 42830 279293 110266958
Mobility decreased 41.87 12.92 20 43028 237402 110308849
Premature delivery 41.03 12.92 55 42993 30577 110515674
Anaemia vitamin B12 deficiency 40.67 12.92 16 43032 1211 110545040
Infection 40.30 12.92 49 42999 362151 110184100
Sinusitis 40.02 12.92 224 42824 296464 110249787
Injection site urticaria 39.98 12.92 41 43007 17174 110529077
Bursitis 39.12 12.92 3 43045 129915 110416336
Discomfort 37.99 12.92 18 43030 214689 110331562
Anti-insulin antibody 37.04 12.92 8 43040 66 110546185
Rheumatoid arthritis 36.37 12.92 220 42828 299393 110246858
Pancreatitis chronic 35.59 12.92 22 43026 4443 110541808
Hyperkalaemia 35.50 12.92 125 42923 135671 110410580
Cough 35.18 12.92 303 42745 461338 110084913
Ill-defined disorder 34.86 12.92 9 43039 156844 110389407
Sleep disorder 34.62 12.92 17 43031 198627 110347624
Completed suicide 33.62 12.92 27 43021 242354 110303897
Joint range of motion decreased 33.56 12.92 4 43044 121828 110424423
Abdominal discomfort 33.50 12.92 64 42984 393794 110152457
Malaise 33.46 12.92 404 42644 671415 109874836
General physical health deterioration 33.38 12.92 281 42767 425014 110121237
Drug abuse 32.75 12.92 14 43034 177397 110368854
Increased insulin requirement 32.55 12.92 9 43039 222 110546029
Diabetic gangrene 32.17 12.92 9 43039 232 110546019
Injection site erythema 32.16 12.92 95 42953 94081 110452170
Product prescribing error 31.68 12.92 65 42983 51266 110494985
Hypoglycaemia unawareness 31.29 12.92 9 43039 257 110545994
Intentional product use issue 30.35 12.92 31 43017 247875 110298376
Asthenia 30.34 12.92 405 42643 688594 109857657
Pancreatitis acute 30.01 12.92 70 42978 60204 110486047
Euglycaemic diabetic ketoacidosis 29.41 12.92 29 43019 11594 110534657
Confusional state 28.87 12.92 294 42754 468386 110077865
Nausea 28.60 12.92 655 42393 1235035 109311216
Stomatitis 28.55 12.92 38 43010 270204 110276047
Therapeutic product effect incomplete 28.53 12.92 27 43021 223778 110322473
Anti-insulin antibody increased 28.29 12.92 7 43041 110 110546141
Device failure 28.20 12.92 23 43025 7184 110539067
Systemic infection 27.68 12.92 26 43022 9793 110536458
Anxiety 27.59 12.92 229 42819 344849 110201402
Liver injury 27.56 12.92 12 43036 150401 110395850
Osteoarthritis 27.05 12.92 19 43029 182604 110363647
Neutropenia 26.79 12.92 67 42981 374553 110171698
Psoriatic arthropathy 25.96 12.92 23 43025 196738 110349513
C-reactive protein increased 25.83 12.92 28 43020 217891 110328360
Syncope 25.38 12.92 150 42898 202386 110343865
Injection site nodule 25.17 12.92 18 43030 4628 110541623
Toxicity to various agents 25.16 12.92 99 42949 480456 110065795
Inflammation 25.00 12.92 23 43025 193215 110353036
Blood ketone body 24.78 12.92 7 43041 187 110546064
Obesity 24.25 12.92 7 43041 113344 110432907
Swelling 24.16 12.92 64 42984 350977 110195274
Toe amputation 23.95 12.92 17 43031 4321 110541930
Product monitoring error 23.95 12.92 23 43025 8904 110537347
Gastric disorder 23.93 12.92 45 43003 33312 110512939
Therapy non-responder 23.78 12.92 16 43032 157291 110388960
Gastrointestinal disorder 23.47 12.92 168 42880 241784 110304467
Dry mouth 23.36 12.92 26 43022 199922 110346329
Dyspepsia 23.23 12.92 24 43024 190941 110355310
Sciatica 23.19 12.92 4 43044 92395 110453856
Visceral congestion 23.02 12.92 11 43037 1334 110544917
Exposure during pregnancy 22.95 12.92 127 42921 167297 110378954
Anuria 22.89 12.92 37 43011 24304 110521947
Multiple lentigines syndrome 22.86 12.92 7 43041 249 110546002
Diabetic retinal oedema 22.85 12.92 8 43040 436 110545815
Rash 22.83 12.92 207 42841 820757 109725494
Pre-eclampsia 22.67 12.92 22 43026 8628 110537623
Injection site rash 22.57 12.92 36 43012 23383 110522868
Diabetic foot 22.50 12.92 16 43032 4079 110542172
Injury 21.88 12.92 22 43026 177243 110369008
Type 2 diabetes mellitus 21.87 12.92 22 43026 177210 110369041
Laryngeal leukoplakia 21.77 12.92 5 43043 56 110546195
Chronic kidney disease 21.48 12.92 72 42976 76219 110470032
Diabetes mellitus 20.62 12.92 85 42963 99296 110446955
Anaemia 20.61 12.92 313 42735 546773 109999478
Gestational hypertension 20.37 12.92 12 43036 2222 110544029
Blister 20.16 12.92 36 43012 227340 110318911
Type 1 diabetes mellitus 20.02 12.92 21 43027 9026 110537225
Vomiting projectile 19.96 12.92 12 43036 2306 110543945
Injection site irritation 19.87 12.92 16 43032 4908 110541343
Diabetic coma 19.86 12.92 10 43038 1358 110544893
Metabolic acidosis 19.67 12.92 84 42964 99660 110446591
Grip strength decreased 19 12.92 4 43044 80170 110466081
Rhonchi 18.91 12.92 15 43033 4503 110541748
Insulin autoimmune syndrome 18.86 12.92 8 43040 734 110545517
Hypersensitivity 18.81 12.92 87 42961 403911 110142340
Delirium 18.77 12.92 15 43033 135010 110411241
Hypercholesterolaemia 18.73 12.92 6 43042 90831 110455420
Upper respiratory tract irritation 18.69 12.92 6 43042 250 110546001
Asthma 18.49 12.92 44 43004 250247 110296004
Night sweats 18.48 12.92 15 43033 133968 110412283
Product dispensing error 18.39 12.92 27 43021 16318 110529933
Peripheral venous disease 18.36 12.92 5 43043 84112 110462139
Loss of personal independence in daily activities 18.08 12.92 19 43029 150001 110396250
Pancreatic carcinoma 17.37 12.92 25 43023 14847 110531404
Product administration error 17.20 12.92 42 43006 37175 110509076
Gait inability 16.74 12.92 17 43031 136359 110409892
Drug hypersensitivity 16.62 12.92 106 42942 453984 110092267
Cardiac failure congestive 16.51 12.92 108 42940 150892 110395359
Insulin-requiring type 2 diabetes mellitus 16.20 12.92 5 43043 183 110546068
Lack of application site rotation 15.82 12.92 4 43044 69 110546182
Product use issue 15.80 12.92 65 42983 311630 110234621
Wound infection 15.70 12.92 9 43039 96456 110449795
Myocardial infarction 15.62 12.92 128 42920 191955 110354296
Cellulitis 15.57 12.92 93 42955 125923 110420328
Diabetic nephropathy 15.45 12.92 12 43036 3496 110542755
Nasopharyngitis 15.37 12.92 227 42821 394134 110152117
Contusion 14.97 12.92 44 43004 233317 110312934
Duodenal neoplasm 14.94 12.92 4 43044 87 110546164
Nonreassuring foetal heart rate pattern 14.87 12.92 3 43045 17 110546234
Cataract subcapsular 14.82 12.92 8 43040 1253 110544998
Episcleritis 14.79 12.92 8 43040 1258 110544993
Acute myocardial infarction 14.60 12.92 68 42980 83709 110462542
Accidental underdose 14.56 12.92 8 43040 1297 110544954
Migraine 14.48 12.92 28 43020 171624 110374627
Injection site hypersensitivity 14.38 12.92 10 43038 2461 110543790
Blood insulin decreased 14.33 12.92 3 43045 21 110546230
Taste disorder 14.06 12.92 4 43044 65383 110480868
Diabetic ketosis 14.05 12.92 7 43041 929 110545322
Cyanopsia 13.98 12.92 4 43044 112 110546139
Knee arthroplasty 13.91 12.92 4 43044 64944 110481307
Cytokine release syndrome 13.87 12.92 5 43043 70301 110475950
Pneumonia 13.71 12.92 442 42606 876272 109669979
Hypertension 13.55 12.92 130 42918 509954 110036297
White blood cell count decreased 13.48 12.92 45 43003 229345 110316906
Macular oedema 13.37 12.92 15 43033 6951 110539300
Treatment noncompliance 13.28 12.92 60 42988 72930 110473321
Paraesthesia 13.19 12.92 59 42989 276462 110269789
Prescribed overdose 13.11 12.92 9 43039 87572 110458679
Wound 13.09 12.92 47 43001 234390 110311861
Decreased insulin requirement 12.94 12.92 4 43044 147 110546104

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
ATC A10AE05 ALIMENTARY TRACT AND METABOLISM
DRUGS USED IN DIABETES
INSULINS AND ANALOGUES
Insulins and analogues for injection, long-acting
FDA CS M0011417 Insulin
FDA Chemical/Ingredient N0000004931 Insulin
FDA EPC N0000175453 Insulin Analog
MeSH PA D007004 Hypoglycemic Agents
FDA EPC N0000175944 Insulin
CHEBI has role CHEBI:22587 antiviral agent
CHEBI has role CHEBI:35469 antidepressant
CHEBI has role CHEBI:35476 antipsychotic agent
CHEBI has role CHEBI:35480 analgesic
CHEBI has role CHEBI:35526 hypoglycemic agent
CHEBI has role CHEBI:35554 cardiovascular drug
CHEBI has role CHEBI:35674 antihypertensive agent
CHEBI has role CHEBI:35705 immunosuppressive agent
CHEBI has role CHEBI:35821 anticholesteremic drug
CHEBI has role CHEBI:39456 antiglaucoma drug
CHEBI has role CHEBI:48407 antiparkinson drug
CHEBI has role CHEBI:50864 insulin-sensitizing drug
CHEBI has role CHEBI:66981 ophthalmology drug
CHEBI has role CHEBI:73336 vulnerary
CHEBI has role CHEBI:74518 anti-obesity agent
CHEBI has role CHEBI:76916 hyperglycemic agent
CHEBI has role CHEBI:145947 antiatherosclerotic agent
CHEBI has role CHEBI:231911 renoprotective agent

Related Drugs by ATC class:

A10AE Insulins and analogues for injection, long-acting 9 drugs
insulin beefinsulin degludecinsulin glargineinsulin humaninsulin icodecinsulin porkliraglutidelixisenatidesemaglutide

Drug Use | Suggest Off label Use Form| |View source of the data|

DiseaseRelationSNOMED_IDDOID
Diabetes mellitus indication 73211009 DOID:9351




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

None

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])		Mechanism
action		Bioact sourceMoA source
Insulin receptor Kinase AGONIST DRUG LABEL DRUG LABEL

External reference:

IDSource
D04539 KEGG_DRUG
4017559 VANDF
4017569 VANDF
4019786 VANDF
CHEBI:750813 CHEBI
CHEMBL2104391 ChEMBL_ID
DB01307 DRUGBANK_ID
139825 RXNORM
19234 MMSL
4885 MMSL
4886 MMSL
72333 MMSL
d00262 MMSL
d04369 MMSL
d05436 MMSL
000869 NDDF
000870 NDDF
006518 NDDF
010059 NDDF
126210001 SNOMEDCT_US
414515005 SNOMEDCT_US
414518007 SNOMEDCT_US
417423002 SNOMEDCT_US
420609005 SNOMEDCT_US
96367001 SNOMEDCT_US
C0537270 UMLSCUI
D000069057 MESH_DESCRIPTOR_UI
C0795635 UMLSCUI
DB00030 DRUGBANK_ID
7735 INN_ID
16137271 PUBCHEM_CID
118984375 PUBCHEM_CID
4FT78T86XV UNII
5186 INN_ID
CHEBI:5931 CHEBI
4FT78T86XV INXIGHT DRUGS

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
Levemir HUMAN PRESCRIPTION DRUG LABEL 1 0169-3687 INJECTION, SOLUTION 100 [iU] SUBCUTANEOUS BLA 26 sections
Levemir HUMAN PRESCRIPTION DRUG LABEL 1 0169-6432 INJECTION, SOLUTION 100 [iU] SUBCUTANEOUS BLA 26 sections
Levemir HUMAN PRESCRIPTION DRUG LABEL 1 0169-6438 INJECTION, SOLUTION 100 [iU] SUBCUTANEOUS BLA 26 sections
Levemir HUMAN PRESCRIPTION DRUG LABEL 1 50090-1276 INJECTION, SOLUTION 100 [iU] SUBCUTANEOUS BLA 26 sections
Levemir HUMAN PRESCRIPTION DRUG LABEL 1 50090-1475 INJECTION, SOLUTION 100 [iU] SUBCUTANEOUS BLA 26 sections
Levemir HUMAN PRESCRIPTION DRUG LABEL 1 54868-5883 INJECTION, SOLUTION 14.20 mg SUBCUTANEOUS NDA 26 sections
Levemir HUMAN PRESCRIPTION DRUG LABEL 1 68258-8977 IMPLANT 14.20 mg SOFT TISSUE NDA 26 sections