DrugCentral 2023 ๐
2022 Update-Veterinary Drugs & Uses
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DrugCentral 2023 ๐
2022 Update-Veterinary Drugs & Uses
Search
Structure ๐
Similarity ๐
Smart API
Redial
About
Download
L1000
FAQ
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FDA-approved
EMA-approved
PMDA-approved
Target Card Uniprot Example:
P23975
ceforanide ๐ถ
Veterinary Use |
Indications/Contra
| FAERs-F
| FAERs-M
| Orange Bk
| BioActivity |
Stem definition
Drug id
CAS RN
antibiotics, cefalosporanic acid derivatives
544
60925-61-3
Description:
Molecule
Description
Molfile
Inchi
Smiles
Synonyms:
ceforanide monosodium salt
ceforanide sodium
BL-S786R
ceforanide
Molecular weight: 519.55
Formula: C20H21N7O6S2
CLOGP: -3.06
LIPINSKI: 2
HAC: 13
HDO: 4
TPSA: 193.63
ALOGS: -3.42
ROTB: 10
Status: OFM
Legend:
OFP - off patent
OFM - off market
ONP - on patent
Drug dosage:
Dose
Unit
Route
4
g
P
ADMET properties:
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Property
Value
Reference
EoM (Fraction excreted unchanged in urine)
84 %
Benet LZ, Broccatelli F, Oprea TI
MRTD (Maximum Recommended Therapeutic Daily Dose)
64.09 ยตM/kg/day
Contrera JF, Matthews EJ, Kruhlak NL, Benz RD
t_half (Half-life)
3 hours
Lombardo F, Berellini G, Obach RS
BDDCS (Biopharmaceutical Drug Disposition Classification System)
3
Benet LZ, Broccatelli F, Oprea TI
CL (Clearance)
0.66 mL/min/kg
Lombardo F, Berellini G, Obach RS
fu (Fraction unbound in plasma)
0.19 %
Lombardo F, Berellini G, Obach RS
Vd (Volume of distribution)
0.17 L/kg
Lombardo F, Berellini G, Obach RS
Showing 1 to 7 of 7 entries
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Approvals:
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Date
Agency
Company
Orphan
May 24, 1984
FDA
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FDA Adverse Event Reporting System (Female)
None
FDA Adverse Event Reporting System (Male)
None
FDA Adverse Event Reporting System (Geriatric)
None
FDA Adverse Event Reporting System (Pediatric)
None
Pharmacologic Action:
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Source
Code
Description
ATC
J01DC11
ANTIINFECTIVES FOR SYSTEMIC USE
ANTIBACTERIALS FOR SYSTEMIC USE
OTHER BETA-LACTAM ANTIBACTERIALS
Second-generation cephalosporins
CHEBI has role
CHEBI:36047
antibacterial drugs
MeSH PA
D000900
Anti-Bacterial Agents
MeSH PA
D000890
Anti-Infective Agents
Showing 1 to 4 of 4 entries
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Drug Use
| Suggest Off label Use Form|
|View source of the data|
None
๐ถ Veterinary Drug Use
None
๐ถ Veterinary products
None
Acid dissociation constants calculated using MoKa v3.0.0
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Dissociation level
Dissociation constant
Type (acidic/basic)
pKa1
2.63
acidic
pKa2
3.92
acidic
pKa3
9.83
Basic
Showing 1 to 3 of 3 entries
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Orange Book patent data (new drug applications)
None
Orange Book exclusivity data (new drug applications)
None
Bioactivity Summary:
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Target
Class
Pharos
UniProt
Action
Type
Activity value
(-log[M])
Mechanism
action
Bioact source
MoA source
Bacterial penicillin-binding protein
Enzyme
PBPA_ECOLI
PBPB_ECOLI
DACC_ECOLI
PBP2_ECOLI
FTSI_ECOLI
DACA_ECOLI
DACB_ECOLI
INHIBITOR
CHEMBL
CHEMBL
Penicillin-binding protein 1A
Enzyme
PBPA_CLOPE
WOMBAT-PK
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External reference:
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entries
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ID
Source
002733
NDDF
12218
IUPHAR_LIGAND_ID
1668008
SNOMEDCT_US
20486
RXNORM
4018152
VUID
4018152
VANDF
43507
PUBCHEM_CID
4465
INN_ID
61336-41-2
SECONDARY_CAS_RN
8M1YF8951V
UNII
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Pharmaceutical products:
None
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ceforanide