cefbuperazone 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | PK/Tox | Related Drugs | BioActivity |

Stem definitionDrug idCAS RN
antibiotics, cefalosporanic acid derivatives 3072 76610-84-9

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • cefbuperazone
  • Molecular weight: 627.65
  • Formula: C22H29N9O9S2
  • CLOGP: -0.46
  • LIPINSKI: 2
  • HAC: 18
  • HDO: 4
  • TPSA: 229.49
  • ALOGS: -2.75
  • ROTB: 10

Drug dosage:

DoseUnitRoute
2 g P

ADMET properties:

PropertyValueReference
BDDCS (Biopharmaceutical Drug Disposition Classification System) 3 Hosey CM, Chan R, Benet LZ
Vd (Volume of distribution) 0.19 L/kg Lombardo F, Berellini G, Obach RS
CL (Clearance) 1.10 mL/min/kg Lombardo F, Berellini G, Obach RS
t_half (Half-life) 1.90 hours Lombardo F, Berellini G, Obach RS

Predicted pharmacokinetic/toxicological properties (PK-AZ):

PropertyDescriptionValueUnitConfidenceSimilarity
kinase-safety-class ACVR2B,AXL,CAMK2D,CDK5,CDK9,EIF2AK3,ERBB2,GRK2,ITK,MAPK7,NTRK2,PDK1,PDK2,PRKDC,TEK 15
kinase-selectivity-class AXL,CDK9,GRK2,MAP2K6,MAPK7,STK33,TEK 7
pfas-class PFAS structural alert (1 = True, 0 = False) 0

Approvals:

None

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

None

FDA Adverse Event Reporting System (Geriatric)

None

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
ATC J01DC13 ANTIINFECTIVES FOR SYSTEMIC USE
ANTIBACTERIALS FOR SYSTEMIC USE
OTHER BETA-LACTAM ANTIBACTERIALS
Second-generation cephalosporins

Related Drugs by ATC class:

J01DC Second-generation cephalosporins 13 drugs
cefaclorcefamandolecefmetazolecefminoxcefonicidceforanidecefotetancefotiamcefoxitincefprozilcefuroximeflomoxef show all 13 →

Drug Use | Suggest Off label Use Form| |View source of the data|

None




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 2.85 acidic
pKa2 13.4 acidic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

None

External reference:

IDSource
D03423 KEGG_DRUG
C0055000 UMLSCUI
CHEBI:135856 CHEBI
CHEMBL1908372 ChEMBL_ID
DB13638 DRUGBANK_ID
C035978 MESH_SUPPLEMENTAL_RECORD_UI
12253 IUPHAR_LIGAND_ID
5216 INN_ID
T0785J3X40 UNII
127527 PUBCHEM_CID
010929 NDDF

Pharmaceutical products:

None