Stem definition | Drug id | CAS RN |
---|---|---|
antibiotics, cefalosporanic acid derivatives | 547 | 69712-56-7 |
Dose | Unit | Route |
---|---|---|
4 | g | P |
Property | Value | Reference |
---|---|---|
BDDCS (Biopharmaceutical Drug Disposition Classification System) | 3 | Benet LZ, Broccatelli F, Oprea TI |
EoM (Fraction excreted unchanged in urine) | 67 % | Benet LZ, Broccatelli F, Oprea TI |
MRTD (Maximum Recommended Therapeutic Daily Dose) | 148.91 ยตM/kg/day | Contrera JF, Matthews EJ, Kruhlak NL, Benz RD |
Vd (Volume of distribution) | 0.13 L/kg | Lombardo F, Berellini G, Obach RS |
CL (Clearance) | 0.42 mL/min/kg | Lombardo F, Berellini G, Obach RS |
fu (Fraction unbound in plasma) | 0.15 % | Lombardo F, Berellini G, Obach RS |
t_half (Half-life) | 4.50 hours | Lombardo F, Berellini G, Obach RS |
Date | Agency | Company | Orphan |
---|---|---|---|
Dec. 27, 1985 | FDA |
None
None
None
None
Source | Code | Description |
---|---|---|
ATC | J01DC05 | ANTIINFECTIVES FOR SYSTEMIC USE ANTIBACTERIALS FOR SYSTEMIC USE OTHER BETA-LACTAM ANTIBACTERIALS Second-generation cephalosporins |
FDA CS | M0003827 | Cephalosporins |
FDA EPC | N0000175488 | Cephalosporin Antibacterial |
CHEBI has role | CHEBI:36047 | antibacterial drugs |
MeSH PA | D000900 | Anti-Bacterial Agents |
MeSH PA | D000890 | Anti-Infective Agents |
Disease | Relation | SNOMED_ID | DOID |
---|---|---|---|
Bacterial septicemia | indication | 10001005 | DOID:0040085 |
Infection of skin AND/OR subcutaneous tissue | indication | 19824006 | |
Staphylococcal pneumonia | indication | 22754005 | |
Pneumonia due to Streptococcus | indication | 34020007 | |
Lower respiratory tract infection | indication | 50417007 | |
Pneumonia due to Escherichia coli | indication | 51530003 | |
Bacterial pneumonia | indication | 53084003 | DOID:874 |
Klebsiella cystitis | indication | 60867007 | |
Acute gonococcal endometritis | indication | 65295003 | DOID:7527 |
Haemophilus influenzae pneumonia | indication | 70036007 | |
Infection due to Escherichia coli | indication | 71057007 | |
Endometritis | indication | 78623009 | DOID:1002 |
Female genital tract infection | indication | 125585007 | |
Infectious disease of abdomen | indication | 128070006 | |
Bacterial infection due to Klebsiella pneumoniae | indication | 186435004 | |
Proteus pneumonia | indication | 195888009 | |
Escherichia coli urinary tract infection | indication | 301011002 | |
Proteus urinary tract infection | indication | 301012009 | |
Streptococcus pyogenes infection | indication | 302809008 | |
Bacterial urinary infection | indication | 312124009 | |
Infection due to Staphylococcus aureus | indication | 406602003 | |
Osteomyelitis due to Staphylococcus aureus | indication | 428783003 | |
Peptostreptococcus infection | indication | 135341000119101 | |
E. Coli Endometritis | indication | ||
Bacteroides Peritonitis | indication | ||
Bacteroides Endometritis | indication | ||
Streptococcal Pelvic Inflammatory Disease | indication | ||
Proteus Endometritis | indication | ||
Staphylococcus Endometritis | indication | ||
Streptococcal Peritonitis | indication | ||
Fusobacterium Endometritis | indication | ||
Peptococcus Pelvic Inflammatory Disease | indication | ||
Skin and Skin Structure Bacteroides Fragilis Infection | indication | ||
Clostridium Peritonitis | indication | ||
Skin and Skin Structure Proteus Infection | indication | ||
Peptococcus Peritonitis | indication | ||
Inflammatory Disease of Female Pelvic Organs | indication | ||
Peptostreptococcus Endometritis | indication | ||
Skin and Skin Structure Streptococcus Agalactiae Infection | indication | ||
E. Coli Peritonitis | indication | ||
Staphylococcus Pelvic Inflammatory Disease | indication | ||
Streptococcal Endometritis | indication | ||
E. Coli Pelvic Inflammatory Disease | indication | ||
Skin and Skin Structure Fusobacterium Infection | indication | ||
Skin and Skin Structure Peptococcus Infection | indication | ||
Peptostreptococcus Pelvic Inflammatory Disease | indication | ||
Staphylococcus Aureus Joint Infection | indication | ||
Staphylococcus Epidermidis Skin and Skin Structure Infection | indication | ||
Fusobacterium Pelvic Inflammatory Disease | indication | ||
Pelvic Inflammatory Disease with Neisseria Gonorrhea | indication | ||
Proteus Pelvic Inflammatory Disease | indication | ||
Prevention of Perioperative Infection | indication | ||
Klebsiella Pneumoniae Peritonitis | indication | ||
Peptococcus Endometritis | indication | ||
Bacteroides Pelvic Inflammatory Disease | indication | ||
Infection of bone | off-label use | 111253001 | |
Infectious disorder of joint | off-label use | 363162000 | |
Vitamin K deficiency | contraindication | 52675005 | DOID:11249 |
Disorder of digestive system | contraindication | 53619000 | DOID:77 |
Hemolytic anemia | contraindication | 61261009 | DOID:583 |
Factor II deficiency | contraindication | 73975000 | |
Kidney disease | contraindication | 90708001 | DOID:557 |
Disease of liver | contraindication | 235856003 | DOID:409 |
Pseudomembranous enterocolitis | contraindication | 397683000 |
None
None
Dissociation level | Dissociation constant | Type (acidic/basic) |
---|---|---|
pKa1 | 2.85 | acidic |
pKa2 | 3.37 | acidic |
pKa3 | 12.14 | acidic |
pKa4 | 13.27 | acidic |
None
None
Target | Class | Pharos | UniProt | Action | Type | Activity value (-log[M]) | Mechanism action | Bioact source | MoA source |
---|---|---|---|---|---|---|---|---|---|
72 kDa type IV collagenase | Enzyme | IC50 | 4.49 | WOMBAT-PK | |||||
Prostaglandin G/H synthase 2 | Enzyme | IC50 | 5.05 | WOMBAT-PK | |||||
Matrix metalloproteinase-9 | Enzyme | IC50 | 4.72 | WOMBAT-PK | |||||
Interstitial collagenase | Enzyme | IC50 | 4.89 | WOMBAT-PK | |||||
Catechol O-methyltransferase | Enzyme | IC50 | 4.85 | WOMBAT-PK | |||||
Bacterial penicillin-binding protein | Enzyme | INHIBITOR | CHEMBL | CHEMBL | |||||
Penicillin-binding protein 1A | Enzyme | WOMBAT-PK |
ID | Source |
---|---|
4019664 | VUID |
N0000147756 | NUI |
D00260 | KEGG_DRUG |
74356-00-6 | SECONDARY_CAS_RN |
203141 | RXNORM |
C0007555 | UMLSCUI |
CHEBI:3499 | CHEBI |
CHEMBL1201098 | ChEMBL_ID |
CHEMBL474579 | ChEMBL_ID |
D015313 | MESH_DESCRIPTOR_UI |
DB01330 | DRUGBANK_ID |
10936 | IUPHAR_LIGAND_ID |
4931 | INN_ID |
48SPP0PA9Q | UNII |
53025 | PUBCHEM_CID |
118717 | MMSL |
4379 | MMSL |
d00055 | MMSL |
002736 | NDDF |
004850 | NDDF |
13585009 | SNOMEDCT_US |
370355004 | SNOMEDCT_US |
46146008 | SNOMEDCT_US |
4018461 | VANDF |
4019664 | VANDF |
Product | Category | Ingredients | NDC | Form | Quantity | Route | Marketing | Label |
---|---|---|---|---|---|---|---|---|
Cefotetan | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0143-9670 | INJECTION, POWDER, FOR SOLUTION | 1 g | INTRAMUSCULAR | ANDA | 18 sections |
Cefotetan | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0143-9671 | INJECTION, POWDER, FOR SOLUTION | 2 g | INTRAMUSCULAR | ANDA | 18 sections |
Cefotetan and Dextrose | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0264-3173 | INJECTION, SOLUTION | 1 g | INTRAVENOUS | NDA | 27 sections |
Cefotetan and Dextrose | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0264-3175 | INJECTION, SOLUTION | 2 g | INTRAVENOUS | NDA | 27 sections |
Cefotan | HUMAN PRESCRIPTION DRUG LABEL | 1 | 52565-052 | INJECTION, POWDER, FOR SOLUTION | 1 g | INTRAVENOUS | NDA | 11 sections |
CEFOTAN | HUMAN PRESCRIPTION DRUG LABEL | 1 | 52565-053 | INJECTION, POWDER, FOR SOLUTION | 2 g | INTRAVENOUS | NDA | 11 sections |
Cefotetan | Human Prescription Drug Label | 1 | 63323-385 | INJECTION, POWDER, FOR SOLUTION | 1 g | INTRAVENOUS | ANDA | 12 sections |
Cefotetan | Human Prescription Drug Label | 1 | 63323-386 | INJECTION, POWDER, FOR SOLUTION | 2 g | INTRAVENOUS | ANDA | 12 sections |