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cefamandole 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | PK/Tox | Related Drugs | BioActivity |
| Stem definition | Drug id | CAS RN |
|---|---|---|
| antibiotics, cefalosporanic acid derivatives | 527 | 34444-01-4 |
Description:
| Molecule | Description |
|---|---|
|
Synonyms:
|
Semisynthetic wide-spectrum cephalosporin with prolonged action, probably due to beta-lactamase resistance. It is used also as the nafate.
Legend: OFP - off patent OFM - off market ONP - on patent |
Drug dosage:
| Dose | Unit | Route |
|---|---|---|
| 6 | g | P |
ADMET properties:
| Property | Value | Reference |
|---|---|---|
| BDDCS (Biopharmaceutical Drug Disposition Classification System) | 3 | Benet LZ, Broccatelli F, Oprea TI |
| S (Water solubility) | 333 mg/mL | Benet LZ, Broccatelli F, Oprea TI |
| EoM (Fraction excreted unchanged in urine) | 96 % | Benet LZ, Broccatelli F, Oprea TI |
| MRTD (Maximum Recommended Therapeutic Daily Dose) | 334.50 µM/kg/day | Contrera JF, Matthews EJ, Kruhlak NL, Benz RD |
| BA (Bioavailability) | 96 % | Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H |
| Vd (Volume of distribution) | 0.16 L/kg | Lombardo F, Berellini G, Obach RS |
| CL (Clearance) | 3.60 mL/min/kg | Lombardo F, Berellini G, Obach RS |
| fu (Fraction unbound in plasma) | 0.25 % | Lombardo F, Berellini G, Obach RS |
| t_half (Half-life) | 0.75 hours | Lombardo F, Berellini G, Obach RS |
Predicted pharmacokinetic/toxicological properties (PK-AZ):
| Property | Description | Value | Unit | Confidence | Similarity |
|---|---|---|---|---|---|
| azlogd74 | LogD at pH 7.4 | -1.741 | High | 1 | |
| caco2-efflux | Caco-2 efflux ratio (BA/AB) | 0.701 | High | 1 | |
| caco2-intrinsic-papp | Caco-2 intrinsic apparent permeability | 0.471 | 10^-6 cm/s | High | 1 |
| dh-clint | Dog hepatocyte intrinsic clearance | 1.208 | uL/min/10^6 cells | High | 1 |
| dppb | Dog plasma protein binding (% unbound) | 55.670 | % | High | 1 |
| fcs-ppb | Fetal calf serum protein binding (% unbound) | 46.780 | % | High | 1 |
| herg | hERG pIC50 | 4.390 | pIC50 | High | 1 |
| hh-clint | Human hepatocyte intrinsic clearance | 1.327 | uL/min/10^6 cells | High | 1 |
| hlm-clint | Human liver microsomal intrinsic clearance | 3.631 | uL/min/mg protein | High | 1 |
| hppb | Human plasma protein binding (% unbound) | 24.960 | % | High | 1 |
| kinase-safety-class | ACVR2B,AURKA,AXL,BRAF,BTK,CAMK2D,CDK5,CDK9,DYRK1B,EIF2AK3,ERBB2,GRK2,GSK3B,ITK,MAPK10,MAPK7,MAPKAPK2,NTRK2,PDK1,PDK2,PDK4,PIK3CB,PIM2,PRKDC,STK33,SYK,TEK,TTK | 28 | |||
| kinase-selectivity-class | AXL,CDK9,DYRK1B,EIF2AK3,ERBB2,GRK2,MAPK7,PRKDC,STK33,TEK | 10 | |||
| mdck-mdr1-efflux | MDCK-MDR1 efflux ratio | 0.447 | High | 1 | |
| mh-clint | Mouse hepatocyte intrinsic clearance | 2.307 | High | 1 | |
| mppb | Mouse plasma protein binding (% unbound) | 62.670 | High | 1 | |
| nih-mdck-mdr1-efflux | NIH MDCK-MDR1 efflux ratio | 0.723 | High | 1 | |
| pfas-class | PFAS structural alert (1 = True, 0 = False) | 0 | |||
| pppb | Pig plasma protein binding (% unbound) | 36.100 | % | High | 1 |
| rh-clint | Rat hepatocyte intrinsic clearance | 0.938 | uL/min/10^6 cells | High | 1 |
| rh-fuinc | Rat hepatocyte fraction unbound in incubation | 88.770 | % | High | 1 |
| rppb | Rat plasma protein binding (% unbound) | 33.030 | % | High | 1 |
| solubility-dd | Solubility at pH 7.4 in DMSO | 954.993 | uM | High | 1 |
Approvals:
None
FDA Adverse Event Reporting System (Female)
None
FDA Adverse Event Reporting System (Male)
None
FDA Adverse Event Reporting System (Geriatric)
None
FDA Adverse Event Reporting System (Pediatric)
None
Pharmacologic Action:
| Source | Code | Description |
|---|---|---|
| ATC | J01DC03 | ANTIINFECTIVES FOR SYSTEMIC USE ANTIBACTERIALS FOR SYSTEMIC USE OTHER BETA-LACTAM ANTIBACTERIALS Second-generation cephalosporins |
| CHEBI has role | CHEBI:33282 | antibacterial agent |
| CHEBI has role | CHEBI:36047 | antibacterial drug |
| MeSH PA | D000890 | Anti-Infective Agents |
| MeSH PA | D000900 | Anti-Bacterial Agents |
Related Drugs by ATC class:
J01DC Second-generation cephalosporins 13 drugs
Drug Use | Suggest Off label Use Form| |View source of the data|
| Disease | Relation | SNOMED_ID | DOID |
|---|---|---|---|
| Septicemia due to Escherichia coli | indication | 9323009 | |
| Bacterial septicemia | indication | 10001005 | DOID:0040085 |
| Infection of skin AND/OR subcutaneous tissue | indication | 19824006 | |
| Staphylococcal pneumonia | indication | 22754005 | |
| Streptococcal septicemia | indication | 29577008 | |
| Pneumonia due to Streptococcus | indication | 34020007 | |
| Peritonitis | indication | 48661000 | |
| Lower respiratory tract infection | indication | 50417007 | |
| Pneumonia due to Escherichia coli | indication | 51530003 | |
| Klebsiella cystitis | indication | 60867007 | |
| Urinary tract infectious disease | indication | 68566005 | |
| Haemophilus influenzae pneumonia | indication | 70036007 | |
| Infection due to Escherichia coli | indication | 71057007 | |
| Infection of bone | indication | 111253001 | |
| Staphylococcal septicemia | indication | 111821004 | |
| Infectious disease of abdomen | indication | 128070006 | |
| Infection due to Enterobacteriaceae | indication | 128945009 | |
| Bacterial infection due to Klebsiella pneumoniae | indication | 186435004 | |
| Proteus pneumonia | indication | 195888009 | |
| Bacterial peritonitis | indication | 197171003 | |
| Pneumonia | indication | 233604007 | DOID:552 |
| Escherichia coli urinary tract infection | indication | 301011002 | |
| Proteus urinary tract infection | indication | 301012009 | |
| Streptococcus pyogenes infection | indication | 302809008 | |
| Bacterial urinary infection | indication | 312124009 | |
| Infectious disorder of joint | indication | 363162000 | |
| Infection due to Staphylococcus aureus | indication | 406602003 | |
| Osteomyelitis due to Staphylococcus aureus | indication | 428783003 | |
| Enterococcus Urinary Tract Infection | indication | ||
| Haemophilus Septicemia | indication | ||
| Skin and Skin Structure Proteus Infection | indication | ||
| Staphylococcus Epidermidis Urinary Tract Infection | indication | ||
| Staphylococcus Aureus Joint Infection | indication | ||
| E. Coli Peritonitis | indication | ||
| Prevention of Perioperative Infection | indication | ||
| Alcoholism | contraindication | 7200002 | |
| Blood coagulation disorder | contraindication | 64779008 | DOID:1247 |
| Factor II deficiency | contraindication | 73975000 | |
| Kidney disease | contraindication | 90708001 | DOID:557 |
| Pseudomembranous enterocolitis | contraindication | 397683000 |
🐶 Veterinary Drug Use
None
🐶 Veterinary products
None
Acid dissociation constants calculated using MoKa v3.0.0
| Dissociation level | Dissociation constant | Type (acidic/basic) |
|---|---|---|
| pKa1 | 2.63 | acidic |
| pKa2 | 11.72 | acidic |
Orange Book patent data (new drug applications)
None
Orange Book exclusivity data (new drug applications)
None
Bioactivity Summary:
| Target | Class | Pharos | UniProt | Action | Type | Activity value (-log[M]) | Mechanism action | Bioact source | MoA source |
|---|---|---|---|---|---|---|---|---|---|
| Solute carrier family 15 member 1 | Transporter | Ki | 2.09 | WOMBAT-PK |
External reference:
| ID | Source |
|---|---|
| 4019658 | VUID |
| N0000147750 | NUI |
| D02344 | KEGG_DRUG |
| 2178 | RXNORM |
| C0007541 | UMLSCUI |
| CHEBI:3480 | CHEBI |
| CHEMBL1146 | ChEMBL_ID |
| D002435 | MESH_DESCRIPTOR_UI |
| DB01326 | DRUGBANK_ID |
| 12210 | IUPHAR_LIGAND_ID |
| 3329 | INN_ID |
| 5CKP8C2LLI | UNII |
| 456255 | PUBCHEM_CID |
| d00062 | MMSL |
| 372801003 | SNOMEDCT_US |
| 61651006 | SNOMEDCT_US |
| SMX | PDB_CHEM_ID |
| XD2 | PDB_CHEM_ID |
| 4019658 | VANDF |
| 004844 | NDDF |
Pharmaceutical products:
None