cefminox 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | PK/Tox | Related Drugs | BioActivity |

Stem definitionDrug idCAS RN
antibiotics, cefalosporanic acid derivatives 540 84305-41-9

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • cefminox
  • Molecular weight: 519.57
  • Formula: C16H21N7O7S3
  • CLOGP: -2.85
  • LIPINSKI: 2
  • HAC: 14
  • HDO: 4
  • TPSA: 202.86
  • ALOGS: -2.68
  • ROTB: 11

Drug dosage:

DoseUnitRoute
4 g P

ADMET properties:

PropertyValueReference
BA (Bioavailability) 0 %

Predicted pharmacokinetic/toxicological properties (PK-AZ):

PropertyDescriptionValueUnitConfidenceSimilarity
azlogd74 LogD at pH 7.4 -2.346 High 0.81
caco2-efflux Caco-2 efflux ratio (BA/AB) 0.944 High 0.81
caco2-intrinsic-papp Caco-2 intrinsic apparent permeability 0.299 10^-6 cm/s High 0.81
dh-clint Dog hepatocyte intrinsic clearance 1.327 uL/min/10^6 cells High 0.81
dppb Dog plasma protein binding (% unbound) 90.440 % High 0.81
fcs-ppb Fetal calf serum protein binding (% unbound) 70.820 % High 0.81
herg hERG pIC50 4.607 pIC50 High 0.81
hh-clint Human hepatocyte intrinsic clearance 1.371 uL/min/10^6 cells High 0.81
hlm-clint Human liver microsomal intrinsic clearance 4.285 uL/min/mg protein High 0.81
hppb Human plasma protein binding (% unbound) 76.180 % High 0.81
kinase-safety-class ACVR2A,ACVR2B,ACVRL1,AURKA,AXL,BRAF,BTK,CAMK2B,CAMK2D,CDK4,CDK5,CDK9,DDR1,DYRK1B,EGFR,EIF2AK3,EPHB4,ERBB2,GRK2,GRK3,GSK3B,ITK,JAK2,JAK3,KDR,MAP2K6,MAP3K14,MAP3K21,MAP3K7,MAPK10,MAPK7,MAPK9,MAPKAPK2,MTOR,NTRK2,PDK1,PDK2,PDK4,PIK3CA,PIK3CB,PIM2,PRKDC,SIK2,SIK3,STK33,SYK,TEK,TGFBR1,TTK 49
kinase-selectivity-class AXL,CDK9,DYRK1B,EIF2AK3,GRK2,MAP2K6,MAPK7,PRKDC,STK33,TEK 10
mdck-mdr1-bcrp-efflux MDCK-MDR1-BCRP efflux ratio 0.436 Moderate 0.69
mdck-mdr1-efflux MDCK-MDR1 efflux ratio 1.265 High 0.81
mh-clint Mouse hepatocyte intrinsic clearance 1.309 High 0.81
mppb Mouse plasma protein binding (% unbound) 89.160 High 0.81
nih-mdck-mdr1-efflux NIH MDCK-MDR1 efflux ratio 1.462 High 0.81
pfas-class PFAS structural alert (1 = True, 0 = False) 0
pppb Pig plasma protein binding (% unbound) 73.090 % High 0.81
rat-kpuu-brain Rat brain Kpuu 0.006 % Moderate 0.69
rh-clint Rat hepatocyte intrinsic clearance 1.549 uL/min/10^6 cells High 0.81
rh-fuinc Rat hepatocyte fraction unbound in incubation 91.620 % High 0.81
rppb Rat plasma protein binding (% unbound) 74.690 % High 0.81
solubility-dd Solubility at pH 7.4 in DMSO 959.401 uM High 0.81

Approvals:

None

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

None

FDA Adverse Event Reporting System (Geriatric)

None

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
ATC J01DC12 ANTIINFECTIVES FOR SYSTEMIC USE
ANTIBACTERIALS FOR SYSTEMIC USE
OTHER BETA-LACTAM ANTIBACTERIALS
Second-generation cephalosporins
MeSH PA D000890 Anti-Infective Agents
MeSH PA D000900 Anti-Bacterial Agents
CHEBI has role CHEBI:33282 antibacterial agent

Related Drugs by ATC class:

J01DC Second-generation cephalosporins 13 drugs
cefaclorcefamandolecefbuperazonecefmetazolecefonicidceforanidecefotetancefotiamcefoxitincefprozilcefuroximeflomoxef show all 13 →

Drug Use | Suggest Off label Use Form| |View source of the data|

None




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 1.95 acidic
pKa2 2.85 acidic
pKa3 9.18 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

None

External reference:

IDSource
D07642 KEGG_DRUG
C2707378 UMLSCUI
CHEBI:135817 CHEBI
CHEMBL1276342 ChEMBL_ID
DB09062 DRUGBANK_ID
C046079 MESH_SUPPLEMENTAL_RECORD_UI
12255 IUPHAR_LIGAND_ID
5679 INN_ID
PW08Y13465 UNII
71141 PUBCHEM_CID
698875003 SNOMEDCT_US
010930 NDDF

Pharmaceutical products:

None