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| Stem definition | Drug id | CAS RN |
|---|---|---|
| enzymes | 5418 | 1947415-68-0 |
| Molecule | Description |
|---|---|
|
Synonyms:
|
Imlifidase is a cysteine protease derived from the immunoglobulin G (IgG)-degrading enzyme of Streptococcus pyogenes that cleaves the heavy chains of all human IgG subclasses but no other immunoglobulins. The cleavage of IgG leads to elimination of Fc-dependent effector functions, including CDC and antibody- dependent cell-mediated cytotoxicity (ADCC). By cleaving all IgG, imlifidase reduces the level of DSA, thus enabling transplantation.
|
| Dose | Unit | Route |
|---|---|---|
| 17.50 | mg | P |
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| Date | Agency | Company | Orphan |
|---|---|---|---|
| Aug. 26, 2020 | EMA | Hansa Biopharma AB |
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| Source | Code | Description |
|---|---|---|
| ATC | L04AA41 | ANTINEOPLASTIC AND IMMUNOMODULATING AGENTS IMMUNOSUPPRESSANTS IMMUNOSUPPRESSANTS Selective immunosuppressants |
| CHEBI has role | CHEBI:231911 | renoprotective agent |
| Disease | Relation | SNOMED_ID | DOID |
|---|---|---|---|
| Transplant of kidney | indication | 70536003 | |
| Renal transplant rejection | indication | 236570004 | |
| Thrombotic thrombocytopenic purpura | contraindication | 78129009 | DOID:10772 |
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| Target | Class | Pharos | UniProt | Action | Type | Activity value (-log[M]) | Mechanism action | Bioact source | MoA source |
|---|---|---|---|---|---|---|---|---|---|
| Immunoglobulin gamma (IgG), heavy chain | Antibody | INHIBITOR | SCIENTIFIC LITERATURE | SCIENTIFIC LITERATURE |
| ID | Source |
|---|---|
| D11470 | KEGG_DRUG |
| UVJ7NL8S2P | UNII |
| C5139878 | UMLSCUI |
| CHEBI:757410 | CHEBI |
| CHEMBL4297981 | ChEMBL_ID |
| DB15258 | DRUGBANK_ID |
| 10617 | INN_ID |
| 39196011000001102 | SNOMEDCT_US |
| 018684 | NDDF |
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