abatacept 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | PK/Tox | Related Drugs | BioActivity |

Stem definitionDrug idCAS RN
cytotoxic T lymphocyte-associated antigen 4 (CTLA-4) receptors 5089 332348-12-6

Description:

MoleculeDescription

Synonyms:

  • abatacept
  • orencia
  • BMS-188667
  • BMS 188667
A fusion protein immunoconjugate of the extracellular domain of CTLA4 and the Fc domain of human IgG1. It functions as a T-cell co-stimulation blocker that inhibits TNF-ALPHA and prevents the activation of T-LYMPHOCYTES. It is used in the treatment of RHEUMATOID ARTHRITIS.
  • Molecular weight:
  • Formula:
  • CLOGP:
  • LIPINSKI: None
  • HAC: None
  • HDO: None
  • TPSA:
  • ALOGS:
  • ROTB: None

Drug dosage:

DoseUnitRoute
27 mg P

ADMET properties:

None

Predicted pharmacokinetic/toxicological properties (PK-AZ):

None

Approvals:

DateAgencyCompanyOrphan
Feb. 21, 2020 PMDA Bristol-Myers Squibb K.K.
Dec. 23, 2005 FDA BRISTOL MYERS SQUIBB

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Joint swelling 8462.97 17.47 13608 615969 489692 89509178
Contraindicated product administered 5609.87 17.47 8834 620743 311305 89687565
Drug ineffective 5029.62 17.47 20882 608695 1363416 88635454
Arthralgia 4271.37 17.47 13458 616119 765064 89233806
Synovitis 3236.38 17.47 7096 622481 322656 89676214
Drug intolerance 3029.91 17.47 8350 621227 439241 89559629
Arthropathy 2950.52 17.47 7294 622283 358948 89639922
Treatment failure 2872.75 17.47 6444 623133 297484 89701386
Pemphigus 2424.99 17.47 6312 623265 320552 89678318
Therapeutic product effect decreased 2390.42 17.47 5675 623902 271896 89726974
Systemic lupus erythematosus 2316.09 17.47 6619 622958 355277 89643593
Pain 2294.80 17.47 13230 616347 983111 89015759
Glossodynia 2086.06 17.47 5914 623663 315865 89683005
Swelling 1956.76 17.47 6875 622702 412183 89586687
Hand deformity 1954.99 17.47 5482 624095 290880 89707990
Acute kidney injury 1647.84 17.47 160 629417 320227 89678643
Alopecia 1597.89 17.47 7237 622340 487834 89511036
Abdominal discomfort 1538.25 17.47 6975 622602 470353 89528517
Anaemia 1520.20 17.47 302 629275 352500 89646370
Hypersensitivity 1482.03 17.47 6667 622910 448010 89550860
Hepatic enzyme increased 1440.89 17.47 5630 623947 355106 89643764
Wound 1428.11 17.47 4989 624588 297991 89700879
Drug interaction 1365.31 17.47 160 629417 276293 89722577
Hypotension 1319.82 17.47 319 629258 325078 89673792
Infection 1269.07 17.47 5428 624149 356666 89642204
Toxicity to various agents 1268.22 17.47 233 629344 287613 89711257
Anti-cyclic citrullinated peptide antibody positive 1250.50 17.47 4048 625529 232385 89766485
Rheumatoid factor positive 1165.48 17.47 3211 626366 168439 89830431
Pericarditis 1148.20 17.47 4302 625275 265849 89733021
Febrile neutropenia 1025.86 17.47 14 629563 158335 89840535
Rheumatoid arthritis 971.87 17.47 5029 624548 357585 89641285
Therapy interrupted 950.91 17.47 1438 628139 48670 89950200
Red blood cell sedimentation rate abnormal 937.41 17.47 992 628585 23212 89975658
Irritable bowel syndrome 931.79 17.47 3364 626213 204084 89794786
Death 930.53 17.47 1081 628496 455470 89543400
Folliculitis 927.39 17.47 3325 626252 201028 89797842
Muscle injury 924.85 17.47 3015 626562 173639 89825231
C-reactive protein abnormal 905.90 17.47 2425 627152 125004 89873866
Impaired healing 903.69 17.47 3618 625959 230581 89768289
Helicobacter infection 895.00 17.47 3529 626048 223321 89775549
Rash 891.49 17.47 8936 620641 787164 89211706
Discomfort 886.87 17.47 4016 625561 270319 89728551
Dehydration 844.21 17.47 163 629414 194284 89804586
Lower respiratory tract infection 843.70 17.47 3714 625863 246945 89751925
Duodenal ulcer perforation 839.68 17.47 3401 626176 217887 89780983
Musculoskeletal stiffness 806.88 17.47 4131 625446 292401 89706469
Product use issue 798.98 17.47 4451 625126 325468 89673402
Constipation 794.43 17.47 482 629095 279913 89718957
Infusion related reaction 783.23 17.47 5265 624312 411515 89587355
Somnolence 779.74 17.47 241 629336 208843 89790027
Ill-defined disorder 767.18 17.47 2923 626654 181968 89816902
Seizure 764.06 17.47 84 629493 152545 89846325
Peripheral swelling 743.14 17.47 5163 624414 407943 89590927
Tremor 737.88 17.47 96 629481 153077 89845793
Neutropenia 728.29 17.47 325 629252 224579 89774291
Blister 696.68 17.47 3557 626020 251441 89747429
Hyponatraemia 693.13 17.47 64 629513 133474 89865396
Sleep disorder due to general medical condition, insomnia type 686.41 17.47 2211 627366 126483 89872387
Nausea 669.93 17.47 4745 624832 1105571 88893299
Adverse event 648.75 17.47 2042 627535 115376 89883494
Chest discomfort 604.72 17.47 114 629463 138251 89860619
Cardiac arrest 594.21 17.47 33 629544 104902 89893968
Device safety feature issue 577.06 17.47 171 629406 143 89998727
Injection site pain 568.59 17.47 247 629330 173452 89825418
Mobility decreased 568.58 17.47 3325 626252 247409 89751461
Pancytopenia 561.24 17.47 83 629494 120180 89878690
Malignant neoplasm progression 555.20 17.47 51 629526 106819 89892051
Disease progression 554.96 17.47 197 629380 156418 89842452
Drug hypersensitivity 538.38 17.47 5248 624329 458361 89540509
Respiratory failure 536.13 17.47 89 629488 118329 89880541
Drug abuse 530.14 17.47 8 629569 82339 89916531
Rheumatic fever 530.10 17.47 2289 627288 150832 89848038
Stomatitis 527.80 17.47 3491 626086 271207 89727663
Loss of personal independence in daily activities 521.53 17.47 2099 627478 134006 89864864
Cough 519.19 17.47 1118 628459 367844 89631026
Maternal exposure during pregnancy 518.49 17.47 4272 625305 355791 89643079
Renal failure 514.14 17.47 137 629440 130870 89868000
Platelet count decreased 508.52 17.47 159 629418 136810 89862060
Sinusitis 508.23 17.47 4097 625480 338991 89659879
Pulmonary embolism 507.39 17.47 140 629437 130680 89868190
Bradycardia 505.64 17.47 17 629560 83830 89915040
Haemoglobin decreased 501.16 17.47 249 629328 161707 89837163
Dyspnoea 491.50 17.47 3846 625731 877109 89121761
Diarrhoea 489.04 17.47 4177 625400 935013 89063857
Balance disorder 486.90 17.47 53 629524 97027 89901843
Electrocardiogram QT prolonged 485.17 17.47 3 629574 72453 89926417
Gastrointestinal haemorrhage 482.69 17.47 38 629539 90210 89908660
Suicide attempt 482.54 17.47 8 629569 75391 89923479
Fall 481.39 17.47 1724 627853 480086 89518784
White blood cell count decreased 473.41 17.47 287 629290 166822 89832048
Dysphagia 472.88 17.47 101 629476 112177 89886693
Neuropathy peripheral 470.60 17.47 181 629396 136789 89862081
Palpitations 465.93 17.47 183 629394 136545 89862325
Sepsis 460.88 17.47 345 629232 179469 89819401
Depressed level of consciousness 460.55 17.47 9 629568 72775 89926095
Gastrointestinal disorder 456.01 17.47 3200 626377 253487 89745383
General physical health deterioration 454.99 17.47 4106 625471 351009 89647861
Red blood cell sedimentation rate increased 448.40 17.47 1428 628149 81167 89917703
Swollen joint count increased 429.95 17.47 1720 627857 109486 89889384
Sleep disorder 424.31 17.47 2588 626989 195442 89803428
Hyperkalaemia 423.94 17.47 5 629572 64959 89933911
Coma 416.98 17.47 21 629556 72611 89926259
Vision blurred 414.87 17.47 125 629452 110168 89888702
Hallucination 413.99 17.47 9 629568 65950 89932920
Feeling abnormal 413.20 17.47 333 629244 166902 89831968
Hypoxia 412.28 17.47 22 629555 72377 89926493
Abdominal pain 411.90 17.47 1391 628186 394330 89604540
Cardio-respiratory arrest 411.40 17.47 5 629572 63135 89935735
Fibromyalgia 408.53 17.47 2642 626935 203627 89795243
Blood cholesterol increased 402.02 17.47 2648 626929 205364 89793506
Hypoglycaemia 401.61 17.47 20 629557 69828 89929042
Epistaxis 401.23 17.47 57 629520 85068 89913802
Myalgia 399.62 17.47 376 629201 174749 89824121
Thrombocytopenia 396.39 17.47 521 629056 208204 89790666
Product dose omission issue 389.61 17.47 909 628668 290778 89708092
Cognitive disorder 386.32 17.47 24 629553 69383 89929487
Neutrophil count decreased 380.08 17.47 31 629546 71501 89927369
Type 2 diabetes mellitus 379.33 17.47 2565 627012 200679 89798191
Psoriatic arthropathy 379.13 17.47 2801 626776 225534 89773336
Inflammation 375.63 17.47 2323 627254 176269 89822601
Knee arthroplasty 375.56 17.47 1352 628225 81830 89917040
Device operational issue 372.56 17.47 168 629409 842 89998028
Tachycardia 371.09 17.47 329 629248 157344 89841526
Chills 367.78 17.47 231 629346 131750 89867120
Agitation 365.23 17.47 26 629551 67072 89931798
Syncope 361.74 17.47 238 629339 132425 89866445
Dyspnoea exertional 361.14 17.47 40 629537 72248 89926622
Multiple organ dysfunction syndrome 359.28 17.47 31 629546 68305 89930565
Anxiety 358.87 17.47 1037 628540 308735 89690135
Dizziness 354.44 17.47 2517 627060 586767 89412103
Suicidal ideation 349.15 17.47 49 629528 73806 89925064
Blood pressure increased 345.88 17.47 521 629056 196696 89802174
Hypokalaemia 344.48 17.47 245 629332 130871 89867999
Blood glucose increased 342.18 17.47 117 629460 95129 89903741
Rheumatoid nodule 338.33 17.47 547 629030 19619 89979251
Oxygen saturation decreased 337.40 17.47 162 629415 107321 89891549
Heart rate increased 335.27 17.47 183 629394 112719 89886151
Lactic acidosis 333.37 17.47 3 629574 50460 89948410
Dysarthria 332.25 17.47 10 629567 54472 89944398
Rhabdomyolysis 329.83 17.47 5 629572 51251 89947619
Metabolic acidosis 329.77 17.47 13 629564 55663 89943207
Nasopharyngitis 327.81 17.47 4291 625286 402813 89596057
C-reactive protein increased 327.03 17.47 2270 627307 179119 89819751
Dry skin 325.51 17.47 103 629474 87970 89910900
Multiple sclerosis relapse 324.93 17.47 8 629569 52297 89946573
Cerebrovascular accident 324.31 17.47 231 629346 123302 89875568
Skin exfoliation 318.84 17.47 46 629531 67867 89931003
Flushing 317.38 17.47 109 629468 88382 89910488
Hip arthroplasty 315.04 17.47 1204 628373 75004 89923866
Liver injury 311.28 17.47 2141 627436 168426 89830444
Wrong technique in product usage process 308.36 17.47 61 629516 71510 89927360
Asthenia 307.74 17.47 2307 627270 531444 89467426
Incorrect dose administered 301.32 17.47 87 629490 78843 89920027
Haematochezia 298.15 17.47 64 629513 70849 89928021
Deep vein thrombosis 297.02 17.47 132 629445 91488 89907382
International normalised ratio increased 294.83 17.47 7 629570 47309 89951561
Ascites 293.93 17.47 8 629569 47732 89951138
Vomiting 293.56 17.47 3790 625787 784503 89214367
Cardiac failure congestive 290.11 17.47 162 629415 98532 89900338
Device malfunction 289.89 17.47 522 629055 20455 89978415
Blood pressure decreased 288.78 17.47 81 629496 74814 89924056
Neoplasm progression 287.72 17.47 4 629573 44482 89954388
Joint range of motion decreased 286.79 17.47 1767 627810 133876 89864994
Swelling face 285.27 17.47 104 629473 81248 89917622
Colitis 282.33 17.47 69 629508 69873 89928997
Encephalopathy 281.50 17.47 9 629568 46435 89952435
Blood bilirubin increased 280.75 17.47 4 629573 43466 89955404
Hyperglycaemia 279.59 17.47 19 629558 50951 89947919
Loss of therapeutic response 277.33 17.47 165 629412 1587 89997283
Myelosuppression 277.18 17.47 26 629551 53565 89945305
Inappropriate schedule of product administration 276.74 17.47 382 629195 149551 89849319
Cardiac failure 275.49 17.47 214 629363 109282 89889588
Weight decreased 275.45 17.47 1531 628046 378379 89620491
Pleural effusion 275.33 17.47 224 629353 111767 89887103
Injection site erythema 274.97 17.47 172 629405 98330 89900540
Atrial fibrillation 274.15 17.47 314 629263 133297 89865573
Condition aggravated 272.55 17.47 5721 623856 589824 89409046
Musculoskeletal pain 266.82 17.47 2070 627507 169181 89829689
Disturbance in attention 266.09 17.47 15 629562 47094 89951776
Disorientation 265.77 17.47 9 629568 44105 89954765
Intentional product use issue 265.33 17.47 2484 627093 214408 89784462
Lethargy 263.38 17.47 58 629519 63081 89935789
Deformity 262.30 17.47 371 629206 11799 89987071
Osteoarthritis 253.77 17.47 2270 627307 193460 89805410
Dysgeusia 252.89 17.47 33 629544 52527 89946343
Drug ineffective for unapproved indication 251.57 17.47 75 629502 66569 89932301
Aphasia 250.20 17.47 11 629566 42801 89956069
Pulmonary fibrosis 244.85 17.47 1428 628149 106075 89892795
Bone pain 244.69 17.47 64 629513 61919 89936951
Product storage error 243.93 17.47 475 629102 19766 89979104
Foot deformity 242.91 17.47 938 628639 58713 89940157
Hepatic function abnormal 240.62 17.47 22 629555 46266 89952604
Drug reaction with eosinophilia and systemic symptoms 240.33 17.47 14 629563 42744 89956126
Bone erosion 238.62 17.47 861 628716 52160 89946710
Pulmonary oedema 237.75 17.47 68 629509 62012 89936858
Blood alkaline phosphatase increased 236.66 17.47 28 629549 48051 89950819
Unresponsive to stimuli 236.15 17.47 6 629571 38115 89960755
Therapeutic product effect incomplete 233.31 17.47 2213 627364 191683 89807187
Hypomagnesaemia 231.04 17.47 3 629574 35585 89963285
Angioedema 229.06 17.47 82 629495 64794 89934076
Depressed mood 228.94 17.47 37 629540 50185 89948685
Oedema peripheral 227.63 17.47 969 628608 256946 89741924
Prescribed overdose 227.02 17.47 1304 628273 96321 89902549
Premature delivery 223.15 17.47 11 629566 38751 89960119
Haemorrhage 221.63 17.47 102 629475 69267 89929603
Hepatic failure 220.30 17.47 14 629563 39714 89959156
Full blood count abnormal 218.61 17.47 8 629569 36589 89962281
Vertigo 217.89 17.47 106 629471 69705 89929165
Thrombosis 217.07 17.47 119 629458 73132 89925738
Sciatica 216.98 17.47 1325 628252 100057 89898813
Dyskinesia 214.79 17.47 9 629568 36525 89962345
Night sweats 214.32 17.47 1581 627996 127185 89871685
Orthostatic hypotension 211.84 17.47 22 629555 41805 89957065
Injury 209.63 17.47 2195 627382 195154 89803716
Rhinorrhoea 209.28 17.47 183 629394 88133 89910737
Swollen tongue 209.17 17.47 34 629543 45922 89952948
Mucosal inflammation 208.33 17.47 70 629507 57555 89941315
Plasma cell myeloma 208.01 17.47 21 629556 40807 89958063
Blood creatinine increased 207.18 17.47 239 629338 101147 89897723
Respiratory distress 206.56 17.47 17 629560 38929 89959941
Pulmonary hypertension 206.27 17.47 26 629551 42497 89956373
Urinary retention 204.33 17.47 15 629562 37729 89961141
Nasal congestion 203.59 17.47 168 629409 83246 89915624
Hypervolaemia 199.78 17.47 6 629571 32751 89966119
Drug tolerance decreased 199.09 17.47 582 628995 31548 89967322
Bursitis 198.75 17.47 1580 627997 130074 89868796
Haematuria 197.71 17.47 11 629566 34926 89963944
Acute respiratory failure 197.03 17.47 31 629546 42887 89955983
Urinary tract infection 195.48 17.47 1281 628296 304351 89694519
Hypophagia 195.36 17.47 14 629563 35923 89962947
Emotional distress 194.45 17.47 16 629561 36646 89962224
Arthritis 192.08 17.47 1891 627686 165424 89833446
Jaundice 191.20 17.47 8 629569 32509 89966361
Restlessness 191.09 17.47 15 629562 35705 89963165
Dysphonia 190.57 17.47 100 629477 62984 89935886
Panniculitis 189.93 17.47 352 629225 14106 89984764
Chronic obstructive pulmonary disease 189.92 17.47 141 629436 73688 89925182
Haematemesis 189.68 17.47 11 629566 33715 89965155
Blood parathyroid hormone decreased 189.64 17.47 320 629257 11896 89986974
Blood potassium decreased 188.93 17.47 49 629528 47678 89951192
Intentional self-injury 188.15 17.47 3 629574 29331 89969539
Foetal exposure during pregnancy 186.44 17.47 36 629541 42939 89955931
Abortion spontaneous 186.33 17.47 71 629506 53985 89944885
Facet joint syndrome 185.94 17.47 1246 628331 97143 89901727
Pallor 183.75 17.47 14 629563 34151 89964719
Granuloma skin 183.67 17.47 293 629284 10387 89988483
Blood calcium decreased 182.38 17.47 6 629571 30176 89968694
Device delivery system issue 181.33 17.47 127 629450 1651 89997219
Respiratory arrest 181.01 17.47 13 629564 33298 89965572
Agranulocytosis 180.96 17.47 17 629560 34985 89963885
Blood urea increased 180.46 17.47 7 629570 30406 89968464
Cholestasis 179.01 17.47 21 629556 36278 89962592
Pneumonia aspiration 178.24 17.47 34 629543 40906 89957964
Speech disorder 178.17 17.47 48 629529 45537 89953333
Hepatocellular injury 177.72 17.47 5 629572 28953 89969917
Generalised tonic-clonic seizure 177.70 17.47 18 629559 34885 89963985
Hepatic cytolysis 177.25 17.47 9 629568 30907 89967963
Osteonecrosis of jaw 175.59 17.47 30 629547 39073 89959797
Coeliac disease 175.54 17.47 694 628883 43916 89954954
Overdose 175.21 17.47 538 629039 157171 89841699
Cholelithiasis 174.38 17.47 73 629504 52433 89946437
Hemiparesis 174.11 17.47 12 629565 31807 89967063
Stevens-Johnson syndrome 173.49 17.47 7 629570 29369 89969501
Blood creatine phosphokinase increased 172.04 17.47 18 629559 34005 89964865
Eczema 170.05 17.47 77 629500 52793 89946077
Shock 169.48 17.47 7 629570 28771 89970099
Drug withdrawal syndrome 169.11 17.47 7 629570 28716 89970154
Urinary incontinence 168.29 17.47 29 629548 37537 89961333
Immunodeficiency 168.03 17.47 670 628907 42564 89956306
Haemoptysis 167.53 17.47 18 629559 33302 89965568
Psychotic disorder 167.39 17.47 13 629564 31217 89967653
Altered state of consciousness 166.58 17.47 14 629563 31518 89967352
Device dislocation 166.25 17.47 14 629563 31468 89967402
Pancreatitis acute 164.97 17.47 16 629561 32099 89966771
Paraesthesia oral 164.68 17.47 15 629562 31644 89967226
Disability 164.48 17.47 639 628938 40106 89958764
Gamma-glutamyltransferase increased 164.20 17.47 32 629545 37920 89960950
Lymphocyte count decreased 163.92 17.47 24 629553 35026 89963844
Mental status changes 163.75 17.47 53 629524 44626 89954244
Irritability 163.17 17.47 26 629551 35636 89963234
Full blood count decreased 163.03 17.47 11 629566 29678 89969192
Hypothyroidism 162.28 17.47 83 629494 53044 89945826
Pericardial effusion 161.61 17.47 30 629547 36803 89962067
Grip strength decreased 161.12 17.47 1149 628428 91427 89907443
Cerebral haemorrhage 158.33 17.47 25 629552 34497 89964373
Metastases to bone 158.04 17.47 4 629573 25501 89973369
Lip swelling 156.00 17.47 38 629539 38572 89960298
Decreased appetite 155.40 17.47 1769 627808 374771 89624099
Presyncope 155.36 17.47 19 629558 31786 89967084
Lip dry 154.77 17.47 1216 628361 99739 89899131
Joint stiffness 153.92 17.47 999 628578 77043 89921827
Blood lactate dehydrogenase increased 153.76 17.47 6 629571 25926 89972944
Acute respiratory distress syndrome 153.59 17.47 12 629565 28674 89970196
Hypercholesterolaemia 153.44 17.47 1213 628364 99679 89899191
Renal impairment 153.42 17.47 313 629264 105108 89893762
Prescribed underdose 151.46 17.47 966 628611 74053 89924817
Cardiogenic shock 151.00 17.47 4 629573 24464 89974406
Chronic kidney disease 150.96 17.47 80 629497 50111 89948759
Ventricular tachycardia 148.98 17.47 5 629572 24703 89974167
Myocardial infarction 148.87 17.47 321 629256 105651 89893219
Premature baby 148.02 17.47 6 629571 25071 89973799
Leukocytosis 147.79 17.47 20 629557 30970 89967900
Cellulitis 147.16 17.47 255 629322 91082 89907788
Circulatory collapse 146.86 17.47 6 629571 24898 89973972
Obstructive airways disorder 146.84 17.47 8 629569 25861 89973009
Macular degeneration 146.49 17.47 41 629536 37929 89960941
Nervousness 144.66 17.47 30 629547 34026 89964844
Eosinophilia 144.52 17.47 15 629562 28518 89970352
Hot flush 143.70 17.47 121 629456 59367 89939503
Acute myocardial infarction 143.61 17.47 33 629544 34857 89964013
Clostridium difficile colitis 143.47 17.47 11 629566 26695 89972175
Abdominal pain lower 142.67 17.47 20 629557 30157 89968713
Temperature regulation disorder 142.61 17.47 314 629263 14265 89984605
Abnormal behaviour 142.33 17.47 3 629574 22625 89976245
Withdrawal syndrome 141.63 17.47 3 629574 22521 89976349
Throat irritation 141.55 17.47 81 629496 48614 89950256
Osteoporosis 141.04 17.47 1150 628427 95381 89903489
Fracture 140.74 17.47 404 629173 21672 89977198
Obesity 138.88 17.47 1228 628349 104279 89894591
Panic attack 138.47 17.47 12 629565 26353 89972517
Pollakiuria 138.30 17.47 30 629547 32975 89965895
Aggression 137.74 17.47 13 629564 26655 89972215
Tubulointerstitial nephritis 137.39 17.47 10 629567 25333 89973537
Accidental exposure to product 137.35 17.47 61 629516 42305 89956565
Pulmonary arterial hypertension 137.32 17.47 12 629565 26175 89972695
Oropharyngeal pain 136.60 17.47 381 629196 114806 89884064
Flatulence 136.59 17.47 58 629519 41309 89957561
Erythema 136.52 17.47 981 628596 228265 89770605
Blood sodium decreased 136.10 17.47 16 629561 27597 89971273
Coagulopathy 136.04 17.47 6 629571 23283 89975587
Staphylococcal infection 135.97 17.47 84 629493 48355 89950515
Electrolyte imbalance 135.85 17.47 7 629570 23738 89975132
Diplopia 135.82 17.47 19 629558 28695 89970175
Tinnitus 135.18 17.47 65 629512 43037 89955833
Coronary artery disease 134.08 17.47 34 629543 33589 89965281
Vaginal haemorrhage 133.96 17.47 27 629550 31244 89967626
Coordination abnormal 133.67 17.47 3 629574 21353 89977517
Tachypnoea 133.35 17.47 3 629574 21306 89977564
Chest pain 133.30 17.47 1498 628079 318147 89680723
Peripheral venous disease 133.16 17.47 1019 628558 82902 89915968
Muscle twitching 132.80 17.47 9 629568 24193 89974677
Arrhythmia 132.52 17.47 64 629513 42268 89956602
Sinus tachycardia 132.24 17.47 20 629557 28493 89970377
Bone marrow failure 131.58 17.47 31 629546 32190 89966680
Liver function test increased 131.12 17.47 1024 628553 83831 89915039
Blood pressure fluctuation 131.10 17.47 103 629474 52310 89946560
Joint destruction 130.91 17.47 287 629290 13000 89985870
Rectal haemorrhage 129.70 17.47 235 629342 82509 89916361
Injection site swelling 128.92 17.47 135 629442 59704 89939166
Productive cough 128.91 17.47 210 629367 76853 89922017
Dysuria 128.89 17.47 56 629521 39345 89959525
Skin discolouration 128.40 17.47 74 629503 44241 89954629
Product prescribing error 127.13 17.47 27 629550 30118 89968752
Face oedema 126.99 17.47 9 629568 23309 89975561
Accidental overdose 126.27 17.47 22 629555 28251 89970619
Disease recurrence 125.60 17.47 52 629525 37601 89961269
Pneumonia 125.38 17.47 3424 626153 634635 89364235
Tenosynovitis 125.08 17.47 298 629279 14269 89984601
Sleep apnoea syndrome 124.88 17.47 33 629544 31714 89967156
Elbow deformity 124.77 17.47 95 629482 1416 89997454
Eye swelling 124.59 17.47 26 629551 29360 89969510
Metastases to liver 123.14 17.47 25 629552 28782 89970088
Eye pruritus 122.41 17.47 26 629551 29001 89969869
Breast cancer stage III 122.27 17.47 1004 628573 83443 89915427
Acute hepatic failure 122.03 17.47 9 629568 22552 89976318
Crying 121.23 17.47 17 629560 25628 89973242
Arthrodesis 121.15 17.47 126 629451 2886 89995984
Inappropriate antidiuretic hormone secretion 121.08 17.47 3 629574 19502 89979368
Food allergy 120.85 17.47 421 629156 25057 89973813
Eye pain 120.68 17.47 79 629498 44089 89954781
Musculoskeletal deformity 119.87 17.47 102 629475 1796 89997074
Upper gastrointestinal haemorrhage 119.20 17.47 11 629566 22965 89975905
Myoclonus 118.79 17.47 3 629574 19165 89979705
Angina pectoris 118.39 17.47 62 629515 39098 89959772
Lymphadenopathy 118.27 17.47 87 629490 45688 89953182
Disseminated intravascular coagulation 118.21 17.47 8 629569 21530 89977340
Cytomegalovirus infection 118.15 17.47 21 629556 26581 89972289
Limb deformity 118.01 17.47 145 629432 4007 89994863
Therapeutic response unexpected 117.57 17.47 9 629568 21871 89976999
Deep vein thrombosis postoperative 117.54 17.47 869 628708 69940 89928930
Device related infection 117.52 17.47 19 629558 25767 89973103
Complication associated with device 117.04 17.47 4 629573 19445 89979425
Nightmare 116.56 17.47 9 629568 21716 89977154
Gastritis 116.38 17.47 73 629504 41680 89957190
Lymphopenia 115.96 17.47 12 629565 22869 89976001
Mental disorder 115.53 17.47 40 629537 32278 89966592
Hypersomnia 115.29 17.47 9 629568 21522 89977348
Wound infection 114.57 17.47 1187 628390 105215 89893655
Visual acuity reduced 114.31 17.47 14 629563 23396 89975474
Dermatitis atopic 112.28 17.47 15 629562 23457 89975413
Lower limb fracture 112.15 17.47 990 628587 84023 89914847
Chromaturia 111.89 17.47 5 629572 19182 89979688
Diabetic ketoacidosis 111.20 17.47 18 629559 24389 89974481
Contusion 111.16 17.47 2403 627174 248813 89750057
Ataxia 111.15 17.47 3 629574 18039 89980831
Mitral valve incompetence 111.14 17.47 13 629564 22511 89976359
Abdominal distension 110.68 17.47 498 629079 130103 89868767
Small intestinal obstruction 110.61 17.47 10 629567 21224 89977646
Dislocation of vertebra 110.09 17.47 716 628861 55252 89943618
Basal cell carcinoma 109.97 17.47 492 629085 32897 89965973
Posterior reversible encephalopathy syndrome 109.97 17.47 13 629564 22326 89976544
Skin necrosis 109.91 17.47 312 629265 16629 89982241
Injection site pruritus 109.86 17.47 127 629450 53707 89945163
Gait inability 109.84 17.47 1525 628052 144931 89853939
Feeling cold 109.08 17.47 28 629549 27437 89971433
Clostridium difficile infection 108.66 17.47 58 629519 36187 89962683
Liver disorder 107.88 17.47 1303 628274 119966 89878904
Transient ischaemic attack 107.79 17.47 85 629492 43091 89955779
Alanine aminotransferase increased 107.79 17.47 439 629138 117899 89880971
Bacteraemia 107.28 17.47 14 629563 22286 89976584
Sneezing 106.72 17.47 37 629540 29832 89969038
Onychomycosis 105.76 17.47 527 629050 36849 89962021
Back pain 105.72 17.47 1558 628019 315617 89683253
Therapy partial responder 105.65 17.47 14 629563 22029 89976841
Eye irritation 105.40 17.47 52 629525 33926 89964944
Unevaluable event 103.93 17.47 137 629440 54711 89944159
Sinus congestion 103.24 17.47 31 629546 27393 89971477
X-ray abnormal 103.12 17.47 603 628974 44821 89954049
Pneumonitis 102.86 17.47 93 629484 44077 89954793
Skin ulcer 101.80 17.47 646 628931 49429 89949441
Cyanosis 101.78 17.47 9 629568 19446 89979424
Ear pain 101.44 17.47 718 628859 56984 89941886
Blood glucose decreased 100.84 17.47 20 629557 23409 89975461
Transfusion 100.54 17.47 5 629572 17483 89981387
Motor dysfunction 100.32 17.47 9 629568 19221 89979649
Therapeutic response shortened 99.59 17.47 19 629558 22860 89976010
SLE arthritis 99.32 17.47 62 629515 655 89998215
Thirst 99.32 17.47 3 629574 16292 89982578
Vaginal discharge 99.18 17.47 10 629567 19454 89979416
Chronic sinusitis 98.99 17.47 22 629555 23780 89975090
Malnutrition 98.69 17.47 8 629569 18550 89980320
Multiple sclerosis 98.59 17.47 35 629542 27805 89971065
Musculoskeletal disorder 98.35 17.47 354 629223 21415 89977455
Cystitis 97.14 17.47 198 629379 66520 89932350
Exostosis 96.84 17.47 667 628910 52467 89946403
Device defective 96.28 17.47 120 629457 3366 89995504
Adjustment disorder with depressed mood 96.19 17.47 700 628877 56053 89942817
Haematoma 96.07 17.47 78 629499 38970 89959900
Heart rate decreased 96.01 17.47 139 629438 53366 89945504
Sensory loss 95.55 17.47 8 629569 18067 89980803
Mental impairment 95.43 17.47 5 629572 16715 89982155
Body height below normal 95.04 17.47 95 629482 2073 89996797
Right ventricular failure 94.97 17.47 11 629566 19194 89979676
Hemiplegia 94.93 17.47 4 629573 16156 89982714
Skin haemorrhage 94.69 17.47 17 629560 21363 89977507
Influenza like illness 94.56 17.47 268 629309 80343 89918527
Acute myeloid leukaemia 94.53 17.47 15 629562 20625 89978245
Intestinal obstruction 94.09 17.47 72 629505 37059 89961811
Sinus bradycardia 93.91 17.47 6 629571 16946 89981924
Joint laxity 93.48 17.47 103 629474 2525 89996345
Head injury 93.36 17.47 50 629527 31138 89967732
Human antichimeric antibody positive 92.92 17.47 86 629491 1700 89997170
Finger deformity 92.48 17.47 463 629114 32434 89966436
Tricuspid valve incompetence 92.45 17.47 6 629571 16725 89982145
Therapy non-responder 92.42 17.47 1398 628179 135306 89863564
Metastases to central nervous system 92.08 17.47 8 629569 17534 89981336
Poisoning 92.03 17.47 3 629574 15214 89983656
Hyperthyroidism 91.78 17.47 10 629567 18300 89980570
Myelodysplastic syndrome 91.76 17.47 17 629560 20886 89977984
Subarachnoid haemorrhage 91.75 17.47 9 629568 17895 89980975
Haemorrhage intracranial 91.66 17.47 3 629574 15159 89983711
Heavy menstrual bleeding 91.63 17.47 16 629561 20514 89978356
Hypoaesthesia oral 91.18 17.47 4 629573 15596 89983274
Ageusia 91.16 17.47 5 629572 16071 89982799
Hyperhidrosis 90.78 17.47 564 629013 135741 89863129
Onychomadesis 90.19 17.47 588 628989 45410 89953460
Eating disorder 90.10 17.47 41 629536 28032 89970838
Hyperlipidaemia 89.80 17.47 24 629553 22892 89975978
Extrapyramidal disorder 89.64 17.47 6 629571 16297 89982573
Osteonecrosis 89.55 17.47 35 629542 26206 89972664
Septic shock 89.30 17.47 293 629284 83867 89915003
Poor quality sleep 89.25 17.47 30 629547 24663 89974207
Blood magnesium decreased 88.61 17.47 5 629572 15688 89983182
Fine motor skill dysfunction 88.19 17.47 145 629432 5274 89993596
Glomerular filtration rate decreased 88.13 17.47 8 629569 16924 89981946
Dystonia 87.40 17.47 8 629569 16811 89982059
Oral mucosal exfoliation 87.40 17.47 83 629494 1697 89997173
Hypoalbuminaemia 86.97 17.47 6 629571 15891 89982979
Rheumatoid lung 86.83 17.47 124 629453 3979 89994891
Anal incontinence 86.30 17.47 7 629570 16223 89982647
Subdural haematoma 86.27 17.47 8 629569 16637 89982233
Cardiac murmur 86.15 17.47 12 629565 18182 89980688
Red blood cell sedimentation rate 85.95 17.47 132 629445 4526 89994344
Autoimmune disorder 85.88 17.47 863 628714 75881 89922989
Procedural pain 85.42 17.47 64 629513 33296 89965574
Pain of skin 85.34 17.47 7 629570 16075 89982795
Fatigue 85.28 17.47 9206 620371 1144817 88854053
Heart rate irregular 85.10 17.47 31 629546 24237 89974633
Adverse drug reaction 84.61 17.47 1208 628369 115493 89883377
Rash papular 84.28 17.47 19 629558 20336 89978534
Renal tubular necrosis 84.20 17.47 4 629573 14551 89984319
Urticaria 84.06 17.47 2803 626774 309931 89688939
Caesarean section 83.97 17.47 14 629563 18563 89980307
Schizophrenia 83.46 17.47 5 629572 14909 89983961
Hyperbilirubinaemia 83.40 17.47 3 629574 13933 89984937
COVID-19 83.27 17.47 760 628817 168083 89830787
Skin fissures 83.06 17.47 21 629556 20788 89978082
Hepatic encephalopathy 82.29 17.47 3 629574 13769 89985101
Blood albumin decreased 82.16 17.47 10 629567 16793 89982077
Sinus disorder 82.05 17.47 71 629506 34376 89964494
Injection site warmth 81.89 17.47 12 629565 17503 89981367
Lung disorder 81.82 17.47 1480 628097 148403 89850467
Lupus vulgaris 81.74 17.47 565 629012 44494 89954376
Lacrimation increased 81.58 17.47 43 629534 27019 89971851
Weight increased 80.40 17.47 3611 625966 414316 89584554
Rash macular 80.26 17.47 56 629521 30224 89968646
Rheumatoid factor negative 80.04 17.47 51 629526 560 89998310
Product administration error 79.63 17.47 42 629535 26381 89972489
Premature labour 79.63 17.47 3 629574 13373 89985497
Leukopenia 79.46 17.47 394 629183 100316 89898554
Hypothermia 79.37 17.47 8 629569 15567 89983303
Muscle spasticity 78.95 17.47 467 629110 34855 89964015
Ocular hyperaemia 78.89 17.47 71 629506 33727 89965143
Impaired quality of life 78.76 17.47 31 629546 23113 89975757
Infusion site pain 78.63 17.47 20 629557 19718 89979152
Sensory disturbance 78.33 17.47 8 629569 15405 89983465
Diabetes mellitus inadequate control 78.25 17.47 17 629560 18667 89980203
Drug resistance 77.21 17.47 59 629518 30390 89968480
Hypoacusis 77.19 17.47 49 629528 27801 89971069
Loss of consciousness 76.87 17.47 614 628963 139624 89859246
Upper-airway cough syndrome 76.54 17.47 8 629569 15127 89983743
Renal disorder 76.51 17.47 90 629487 37769 89961101
Respiratory disorder 76.49 17.47 737 628840 64079 89934791
Paranoia 76.48 17.47 3 629574 12905 89985965
Nail disorder 76.43 17.47 685 628892 58382 89940488
Therapeutic response decreased 75.86 17.47 955 628622 88774 89910096
Psychomotor hyperactivity 75.85 17.47 3 629574 12810 89986060
Ventricular extrasystoles 75.51 17.47 4 629573 13246 89985624
Throat tightness 74.93 17.47 57 629520 29427 89969443
Cerebral infarction 74.81 17.47 46 629531 26550 89972320
Blindness 74.67 17.47 46 629531 26522 89972348
Metastases to lung 74.66 17.47 11 629566 15980 89982890
Head discomfort 74.51 17.47 12 629565 16321 89982549
Aspartate aminotransferase increased 73.80 17.47 416 629161 102521 89896349
Anti-cyclic citrullinated peptide antibody 73.63 17.47 379 629198 26842 89972028
Fungal infection 72.52 17.47 115 629462 42546 89956324
Joint dislocation 72.20 17.47 544 629033 44038 89954832
Atelectasis 71.80 17.47 40 629537 24369 89974501
Nephropathy toxic 71.78 17.47 4 629573 12684 89986186
Purpura 71.76 17.47 9 629568 14769 89984101
Myopathy 71.41 17.47 6 629571 13512 89985358
Radiculopathy 71.35 17.47 20 629557 18485 89980385
Diverticulum 71.15 17.47 3 629574 12110 89986760
Fistula 70.99 17.47 3 629574 12086 89986784
Rash maculo-papular 70.86 17.47 109 629468 40824 89958046
Retinitis 70.81 17.47 484 629093 37974 89960896
Blood triglycerides increased 70.30 17.47 7 629570 13754 89985116
Vascular device infection 70.07 17.47 3 629574 11949 89986921
Cardiac failure acute 69.92 17.47 3 629574 11926 89986944
Road traffic accident 69.43 17.47 1092 628485 106534 89892336
Peritonitis 69.39 17.47 25 629552 19680 89979190
Rales 69.20 17.47 13 629564 15814 89983056
Cytopenia 68.89 17.47 18 629559 17431 89981439
Seronegative arthritis 68.79 17.47 280 629297 17954 89980916
Peripheral coldness 68.59 17.47 8 629569 13884 89984986
Eosinophil count increased 68.57 17.47 6 629571 13075 89985795
No adverse event 68.50 17.47 242 629335 67740 89931130
Cardiomegaly 68.38 17.47 23 629554 18902 89979968
Haemolytic anaemia 68.36 17.47 3 629574 11694 89987176
Incontinence 68.20 17.47 7 629570 13428 89985442
Pneumothorax 68.04 17.47 24 629553 19143 89979727
Vitamin D deficiency 67.64 17.47 19 629558 17537 89981333
Mania 67.62 17.47 9 629568 14115 89984755
Blood calcium increased 67.60 17.47 4 629573 12054 89986816
Ileus 67.40 17.47 16 629561 16530 89982340
Back injury 67.31 17.47 554 629023 46068 89952802
Cardiomyopathy 67.24 17.47 28 629549 20178 89978692
Drug eruption 67.22 17.47 449 629128 34958 89963912
Hypovolaemia 67.12 17.47 5 629572 12426 89986444
Dysstasia 66.84 17.47 46 629531 25006 89973864
Surgical failure 66.77 17.47 55 629522 924 89997946
Thrombotic microangiopathy 66.59 17.47 14 629563 15729 89983141
Wheelchair user 66.56 17.47 159 629418 7626 89991244
Hypotonia 66.55 17.47 3 629574 11423 89987447
Tuberculin test positive 66.55 17.47 104 629473 3621 89995249
Left ventricular dysfunction 66.42 17.47 11 629566 14658 89984212
Pyrexia 66.34 17.47 3833 625744 656652 89342218
Pulmonary toxicity 65.88 17.47 203 629374 11328 89987542
Oesophagitis 65.84 17.47 19 629558 17230 89981640
Ischaemic stroke 65.67 17.47 36 629541 22130 89976740
Influenza 65.60 17.47 634 628943 138630 89860240
Gastrooesophageal reflux disease 65.59 17.47 789 628788 165548 89833322
Bronchitis chronic 65.49 17.47 118 629459 4625 89994245
Cardiac disorder 65.29 17.47 191 629386 56681 89942189
Rhinitis allergic 64.98 17.47 18 629559 16767 89982103
Haemophagocytic lymphohistiocytosis 64.87 17.47 14 629563 15445 89983425
Haemorrhoids 64.87 17.47 54 629523 26648 89972222
Glaucoma 64.75 17.47 301 629276 20454 89978416
Troponin increased 64.71 17.47 8 629569 13273 89985597
Bone swelling 64.67 17.47 70 629507 1681 89997189
Blood pressure diastolic decreased 64.25 17.47 55 629522 26771 89972099
Faeces discoloured 64.08 17.47 34 629543 21286 89977584
Sputum discoloured 63.56 17.47 31 629546 20360 89978510
Myocardial ischaemia 63.36 17.47 10 629567 13804 89985066
Erythema multiforme 63.17 17.47 6 629571 12240 89986630
Red cell distribution width decreased 62.91 17.47 77 629500 2119 89996751
Breast cancer metastatic 62.90 17.47 14 629563 15118 89983752
Product use in unapproved indication 62.89 17.47 1816 627761 334420 89664450
Drug tolerance 62.80 17.47 269 629308 17647 89981223
Stress cardiomyopathy 62.78 17.47 9 629568 13346 89985524
Increased appetite 62.76 17.47 5 629572 11760 89987110
Haematocrit decreased 62.73 17.47 122 629455 41710 89957160
Splenomegaly 62.44 17.47 8 629569 12916 89985954
Systemic lupus erythematosus rash 62.43 17.47 80 629497 2309 89996561
Supraventricular tachycardia 62.35 17.47 18 629559 16318 89982552
Temperature intolerance 61.77 17.47 6 629571 12024 89986846
Seasonal allergy 61.58 17.47 42 629535 22941 89975929
Glycosylated haemoglobin increased 61.54 17.47 16 629561 15546 89983324
Live birth 61.44 17.47 829 628748 78278 89920592
Hypertension 61.31 17.47 3821 625756 453711 89545159
Oliguria 61.20 17.47 3 629574 10621 89988249
Middle insomnia 61.15 17.47 20 629557 16731 89982139
Oral candidiasis 60.81 17.47 95 629482 35360 89963510
Aspiration 60.43 17.47 17 629560 15676 89983194
Urine output decreased 60.41 17.47 8 629569 12595 89986275
Vascular access complication 60.24 17.47 79 629498 2334 89996536
Injection site mass 59.68 17.47 40 629537 22050 89976820
Pseudomonas infection 59.33 17.47 15 629562 14850 89984020
Central nervous system lesion 59.30 17.47 6 629571 11640 89987230
Transplant rejection 59.05 17.47 9 629568 12749 89986121
Electrocardiogram abnormal 59.03 17.47 3 629574 10295 89988575
Physical disability 58.79 17.47 102 629475 3879 89994991
Product contamination physical 58.73 17.47 30 629547 207 89998663
Wrist deformity 58.68 17.47 91 629486 3147 89995723
Hyperaesthesia 58.66 17.47 4 629573 10698 89988172
Cold sweat 58.59 17.47 13 629564 14068 89984802
Eyelid oedema 58.58 17.47 6 629571 11528 89987342
Concomitant disease aggravated 58.48 17.47 6 629571 11512 89987358
Dementia 58.28 17.47 48 629529 23813 89975057
Mood altered 58.28 17.47 23 629554 17121 89981749
Shock haemorrhagic 58.16 17.47 8 629569 12237 89986633
Infusion site erythema 58.15 17.47 12 629565 13658 89985212
Lung infiltration 58.03 17.47 17 629560 15265 89983605
Amenorrhoea 57.26 17.47 7 629570 11715 89987155
Metastases to lymph nodes 57.05 17.47 7 629570 11682 89987188
Loose body in joint 57.02 17.47 59 629518 1343 89997527
Enterococcal infection 56.99 17.47 3 629574 9988 89988882
Product dose omission in error 56.93 17.47 36 629541 20467 89978403
Complication of device insertion 56.91 17.47 4 629573 10432 89988438
Arteriosclerosis 56.83 17.47 5 629572 10848 89988022
Abnormal dreams 56.80 17.47 6 629571 11251 89987619
Neutrophil count increased 56.71 17.47 32 629545 19358 89979512
Second primary malignancy 56.53 17.47 4 629573 10374 89988496
Musculoskeletal chest pain 56.51 17.47 49 629528 23701 89975169
Toothache 56.46 17.47 43 629534 22187 89976683
Transaminases increased 56.18 17.47 108 629469 37084 89961786
Hepatomegaly 56.06 17.47 12 629565 13314 89985556
Stress 55.64 17.47 334 629243 81061 89917809
Affect lability 55.49 17.47 28 629549 18035 89980835
Pre-eclampsia 55.46 17.47 6 629571 11042 89987828
Apathy 55.41 17.47 6 629571 11034 89987836
Depression 55.33 17.47 1627 627950 298974 89699896
Bronchopulmonary aspergillosis 55.20 17.47 7 629570 11391 89987479
Gestational diabetes 55.08 17.47 5 629572 10577 89988293
Myocarditis 54.97 17.47 14 629563 13792 89985078
Thinking abnormal 54.94 17.47 8 629569 11724 89987146
Demyelination 54.85 17.47 152 629425 7988 89990882
Dialysis 54.77 17.47 7 629570 11322 89987548
Adjustment disorder 54.67 17.47 3 629574 9639 89989231
Hepatitis 54.39 17.47 740 628837 69999 89928871
Nasal polyps 54.38 17.47 6 629571 10874 89987996
Polyuria 54.32 17.47 4 629573 10036 89988834
Infusion site reaction 54.25 17.47 269 629308 18770 89980100
Spinal column injury 54.23 17.47 71 629506 2094 89996776
Acute coronary syndrome 53.96 17.47 6 629571 10807 89988063
Petechiae 53.71 17.47 21 629556 15720 89983150
Red blood cell count decreased 53.69 17.47 155 629422 46196 89952674
Mean platelet volume decreased 53.59 17.47 83 629494 2867 89996003
Feeling hot 53.38 17.47 320 629257 77688 89921182
Ankle arthroplasty 53.33 17.47 81 629496 2750 89996120
Scratch 53.18 17.47 4 629573 9862 89989008
Arterial occlusive disease 52.79 17.47 11 629566 12435 89986435
Intentional product misuse 52.54 17.47 385 629192 89219 89909651
Initial insomnia 52.47 17.47 3 629574 9307 89989563
Drug level decreased 52.29 17.47 4 629573 9726 89989144
Polyarthritis 52.10 17.47 259 629318 18091 89980779
Peripheral sensory neuropathy 52.07 17.47 3 629574 9247 89989623
C-reactive protein 52.07 17.47 385 629192 30982 89967888
Ankle operation 51.93 17.47 58 629519 1444 89997426
Pre-existing condition improved 51.53 17.47 3 629574 9166 89989704
Cholecystitis 51.47 17.47 27 629550 17013 89981857
Facial pain 51.28 17.47 14 629563 13168 89985702
Lupus-like syndrome 51.18 17.47 542 629035 48304 89950566
Salivary hypersecretion 51.02 17.47 3 629574 9089 89989781
Carotid artery thrombosis 51.02 17.47 3 629574 9089 89989781
Muscle tightness 50.94 17.47 15 629562 13424 89985446
Device breakage 50.86 17.47 17 629560 14027 89984843
Injection site bruising 50.85 17.47 189 629388 52118 89946752
Dermatitis bullous 50.79 17.47 6 629571 10310 89988560
Respiratory rate increased 50.37 17.47 24 629553 15977 89982893
Blood test abnormal 50.13 17.47 43 629534 20909 89977961
Mood swings 50.13 17.47 42 629535 20660 89978210
Hypernatraemia 50.05 17.47 4 629573 9383 89989487
Progressive multifocal leukoencephalopathy 50.03 17.47 23 629554 15632 89983238
Foetal growth restriction 50.00 17.47 4 629573 9376 89989494
Blepharospasm 49.83 17.47 597 628980 54848 89944022
Blood loss anaemia 49.67 17.47 6 629571 10134 89988736
Polyneuropathy 49.65 17.47 37 629540 19304 89979566
Abdominal tenderness 49.64 17.47 4 629573 9320 89989550
Facial paralysis 49.36 17.47 23 629554 15511 89983359
Skin disorder 49.23 17.47 114 629463 36592 89962278
Nodule 49.22 17.47 336 629241 26350 89972520
Walking aid user 49.17 17.47 418 629159 35088 89963782
Body temperature increased 49.16 17.47 501 629076 44209 89954661
Neuralgia 48.88 17.47 90 629487 31410 89967460
Atrial flutter 48.86 17.47 8 629569 10750 89988120
Multiple fractures 48.86 17.47 162 629415 9400 89989470
Arteriosclerosis coronary artery 48.76 17.47 5 629572 9598 89989272
Retching 48.74 17.47 37 629540 19122 89979748
Ovarian cyst 48.65 17.47 30 629547 17288 89981582
Muscle spasms 48.45 17.47 1355 628222 250528 89748342
Enteritis 48.42 17.47 7 629570 10314 89988556
Dermatitis contact 48.30 17.47 17 629560 13578 89985292
Restless legs syndrome 48.05 17.47 51 629526 22419 89976451
Emotional disorder 47.97 17.47 22 629555 14975 89983895
Micturition urgency 47.49 17.47 10 629567 11223 89987647
Proteinuria 47.46 17.47 55 629522 23236 89975634
Confusional state 47.30 17.47 3201 626376 383004 89615866
Hereditary angioedema 47.23 17.47 5 629572 9360 89989510
Escherichia infection 46.82 17.47 26 629551 15869 89983001
Paraesthesia 46.78 17.47 1352 628225 248974 89749896
Infusion site swelling 46.44 17.47 12 629565 11708 89987162
Hyperthermia 46.24 17.47 8 629569 10327 89988543
Injection site rash 46.18 17.47 60 629517 24113 89974757
Adverse reaction 46.13 17.47 359 629218 29353 89969517
Acute pulmonary oedema 46.12 17.47 6 629571 9574 89989296
Bone density decreased 45.88 17.47 240 629337 17105 89981765
Sudden death 45.53 17.47 10 629567 10899 89987971
Low birth weight baby 45.40 17.47 6 629571 9461 89989409
Dizziness postural 45.23 17.47 5 629572 9048 89989822
Bacterial infection 44.99 17.47 58 629519 23386 89975484
Intestinal perforation 44.97 17.47 20 629557 13861 89985009
Joint injury 44.95 17.47 384 629193 32280 89966590
Eyelid ptosis 44.93 17.47 5 629572 9001 89989869
Renal cyst 44.64 17.47 17 629560 12933 89985937
Respiratory acidosis 44.60 17.47 3 629574 8116 89990754
Choking 44.58 17.47 14 629563 12019 89986851
Ulcer 44.43 17.47 385 629192 32497 89966373
Wrist surgery 44.38 17.47 43 629534 902 89997968
Hypokinesia 44.36 17.47 27 629550 15670 89983200
Haemolysis 44.35 17.47 4 629573 8506 89990364
Device occlusion 44.24 17.47 6 629571 9276 89989594
Intermenstrual bleeding 43.86 17.47 6 629571 9217 89989653
Acne 43.74 17.47 82 629495 28425 89970445
Presbyacusis 43.70 17.47 77 629500 2965 89995905
Anticipatory anxiety 43.29 17.47 48 629529 1185 89997685
Hydronephrosis 43.22 17.47 16 629561 12386 89986484
Mesenteritis 43.08 17.47 28 629549 319 89998551
Feeding disorder 43.06 17.47 35 629542 17477 89981393
Enterocolitis 43.01 17.47 10 629567 10480 89988390
Atrial septal defect 42.56 17.47 4 629573 8230 89990640
Hiatus hernia 42.51 17.47 69 629508 25292 89973578
Multiple-drug resistance 42.35 17.47 3 629574 7773 89991097
Major depression 42.29 17.47 9 629568 10026 89988844
Limb injury 42.14 17.47 98 629479 31410 89967460
Bronchospasm 42.09 17.47 49 629528 20660 89978210
Pulseless electrical activity 42.03 17.47 6 629571 8926 89989944
Skin irritation 41.92 17.47 21 629556 13582 89985288
Pharyngitis streptococcal 41.85 17.47 18 629559 12724 89986146
Pathogen resistance 41.79 17.47 4 629573 8111 89990759
Lower gastrointestinal haemorrhage 41.78 17.47 6 629571 8886 89989984
Blood pressure abnormal 41.55 17.47 45 629532 19600 89979270
Hepatitis acute 41.54 17.47 12 629565 10875 89987995
Rib fracture 41.49 17.47 75 629502 26360 89972510
Atrioventricular block 41.30 17.47 6 629571 8809 89990061
Fear 41.14 17.47 33 629544 16589 89982281
Failure to thrive 41.14 17.47 5 629572 8406 89990464
Blood glucose abnormal 41.07 17.47 8 629569 9484 89989386
Pancreatitis 40.94 17.47 300 629277 69526 89929344
Extra dose administered 40.93 17.47 7 629570 9111 89989759
Faecaloma 40.73 17.47 11 629566 10420 89988450
Body temperature decreased 40.67 17.47 64 629513 23752 89975118
Sebaceous gland infection 40.62 17.47 21 629556 149 89998721
Cholecystitis acute 40.53 17.47 8 629569 9396 89989474
Drug effective for unapproved indication 40.52 17.47 4 629573 7914 89990956
Large intestine perforation 40.34 17.47 9 629568 9703 89989167
Bundle branch block left 40.31 17.47 4 629573 7881 89990989
COVID-19 pneumonia 40.30 17.47 40 629537 18137 89980733
Pruritus allergic 40.23 17.47 55 629522 1693 89997177
Flank pain 39.59 17.47 45 629532 19177 89979693
Congestive cardiomyopathy 39.58 17.47 3 629574 7351 89991519
Graft versus host disease 39.45 17.47 5 629572 8139 89990731
White blood cell count increased 39.38 17.47 289 629288 66952 89931918
Hypocalcaemia 39.31 17.47 156 629421 42212 89956658
Injection site induration 39.10 17.47 12 629565 10456 89988414
Menstruation irregular 38.91 17.47 5 629572 8055 89990815
Muscle atrophy 38.71 17.47 6 629571 8395 89990475
Foot operation 38.66 17.47 144 629433 8857 89990013
Osteoporotic fracture 38.64 17.47 95 629482 4641 89994229
Pelvic pain 38.63 17.47 30 629547 15327 89983543
Device issue 38.60 17.47 93 629484 29444 89969426
Paronychia 38.57 17.47 5 629572 8001 89990869
Cerebral ischaemia 38.55 17.47 3 629574 7193 89991677
Product temperature excursion issue 38.54 17.47 39 629538 864 89998006
Respiration abnormal 38.30 17.47 5 629572 7958 89990912
Pemphigoid 38.23 17.47 8 629569 9018 89989852
Peptic ulcer haemorrhage 38.17 17.47 43 629534 1081 89997789
Pulmonary mass 38.07 17.47 90 629487 28682 89970188
Eructation 37.99 17.47 14 629563 10868 89988002
Gout 37.49 17.47 37 629540 16822 89982048
Nephropathy 37.48 17.47 9 629568 9226 89989644
Oral pain 37.34 17.47 110 629467 32573 89966297
Blood urine present 37.19 17.47 39 629538 17239 89981631
Protein urine present 37.17 17.47 3 629574 6981 89991889
Breast pain 37.06 17.47 13 629564 10405 89988465
Laryngitis 37.02 17.47 526 629051 50227 89948643
Appetite disorder 36.87 17.47 9 629568 9124 89989746
Post procedural haemorrhage 36.85 17.47 8 629569 8790 89990080
Dermatitis allergic 36.75 17.47 226 629351 17101 89981769
Colitis ischaemic 36.65 17.47 20 629557 12326 89986544
Cachexia 36.48 17.47 3 629574 6875 89991995
Photophobia 36.47 17.47 57 629520 21212 89977658
Muscle strain 36.37 17.47 11 629566 9676 89989194
Papule 36.23 17.47 6 629571 7996 89990874
Gingival pain 36.17 17.47 11 629566 9641 89989229
Aspergillus infection 36.01 17.47 15 629562 10808 89988062
Cytomegalovirus viraemia 35.92 17.47 5 629572 7581 89991289
Concussion 35.90 17.47 16 629561 11075 89987795
Pleural fibrosis 35.79 17.47 78 629499 3518 89995352
Herpes simplex 35.71 17.47 13 629564 10168 89988702
Metabolic encephalopathy 35.66 17.47 3 629574 6749 89992121
Viral infection 35.62 17.47 157 629420 41257 89957613
Coronary artery occlusion 35.38 17.47 8 629569 8546 89990324
Exposure via skin contact 35.35 17.47 15 629562 10690 89988180
Blood iron abnormal 35.34 17.47 83 629494 3937 89994933
Joint arthroplasty 35.27 17.47 76 629501 3401 89995469
Hip fracture 35.19 17.47 115 629462 32962 89965908
Frequent bowel movements 35.15 17.47 241 629336 56694 89942176
Injection site urticaria 35.14 17.47 44 629533 17967 89980903
Diarrhoea haemorrhagic 35.12 17.47 15 629562 10648 89988222
Joint effusion 35.07 17.47 246 629331 19464 89979406
Diverticulum intestinal 35.02 17.47 10 629567 9132 89989738
Autoimmune hepatitis 35.00 17.47 14 629563 10337 89988533
Colitis microscopic 34.93 17.47 162 629415 10997 89987873
Skin laceration 34.80 17.47 81 629496 25954 89972916
Loss of employment 34.66 17.47 69 629508 2918 89995952
Systemic inflammatory response syndrome 34.13 17.47 3 629574 6513 89992357
Drug specific antibody 34.05 17.47 62 629515 2450 89996420
Soft tissue disorder 33.89 17.47 85 629492 4205 89994665
Intestinal ischaemia 33.51 17.47 10 629567 8873 89989997
Device leakage 33.48 17.47 148 629429 9843 89989027
Vitreous floaters 33.44 17.47 6 629571 7543 89991327
Transaminases abnormal 33.39 17.47 33 629544 710 89998160
Illness 33.34 17.47 775 628802 81194 89917676
Injection site haemorrhage 33.31 17.47 94 629483 28224 89970646
Burning sensation 33.30 17.47 281 629296 63171 89935699
Product complaint 33.17 17.47 27 629550 13473 89985397
Perineal rash 33.13 17.47 15 629562 76 89998794
Dental caries 33.06 17.47 19 629558 11378 89987492
Vitamin B12 deficiency 33.05 17.47 6 629571 7480 89991390
Psychiatric symptom 32.99 17.47 5 629572 7113 89991757
Endocarditis 32.96 17.47 5 629572 7108 89991762
Skin plaque 32.91 17.47 14 629563 9961 89988909
Gastric haemorrhage 32.90 17.47 5 629572 7098 89991772
Gastrointestinal procedural complication 32.71 17.47 27 629550 455 89998415
Low density lipoprotein increased 32.58 17.47 8 629569 8077 89990793
Blood pressure diastolic abnormal 32.48 17.47 55 629522 19826 89979044
Blindness unilateral 32.47 17.47 7 629570 7729 89991141
Nail operation 32.38 17.47 52 629525 1854 89997016
Infiltration anaesthesia 32.35 17.47 19 629558 178 89998692
Necrosis 32.16 17.47 4 629573 6606 89992264
Therapy change 32.07 17.47 9 629568 8313 89990557
Wrong product administered 32.05 17.47 7 629570 7658 89991212
Personality change 32.04 17.47 6 629571 7315 89991555
Abscess 32.04 17.47 51 629526 18840 89980030
Limb operation 31.97 17.47 86 629491 4441 89994429
Skin neoplasm excision 31.55 17.47 49 629528 1697 89997173
Lung opacity 31.45 17.47 3 629574 6099 89992771
Haemorrhagic stroke 31.44 17.47 4 629573 6492 89992378
Tooth loss 31.38 17.47 7 629570 7547 89991323
Gait disturbance 31.31 17.47 2156 627421 258340 89740530
Spinal osteoarthritis 31.25 17.47 53 629524 19095 89979775
Hypertensive crisis 31.12 17.47 47 629530 17737 89981133
Faeces soft 31.12 17.47 7 629570 7504 89991366
Ecchymosis 31.09 17.47 24 629553 12299 89986571
Thyroid neoplasm 31.07 17.47 79 629498 3942 89994928
Metabolic disorder 30.87 17.47 7 629570 7463 89991407
Brain natriuretic peptide increased 30.82 17.47 3 629574 6002 89992868
Infusion site pruritus 30.79 17.47 5 629572 6760 89992110
Pulmonary alveolar haemorrhage 30.78 17.47 3 629574 5995 89992875
Stillbirth 30.71 17.47 7 629570 7436 89991434
Hypovolaemic shock 30.65 17.47 6 629571 7088 89991782
Protein total decreased 30.62 17.47 6 629571 7083 89991787
Blood pressure systolic decreased 30.60 17.47 13 629564 9257 89989613
Candida infection 30.59 17.47 127 629450 33930 89964940
Feeling jittery 30.57 17.47 37 629540 15334 89983536
Respiratory tract infection 30.39 17.47 263 629314 58815 89940055
Neck pain 30.19 17.47 1020 628557 112943 89885927
Abortion induced 30.19 17.47 23 629554 11865 89987005
Lumbosacral plexopathy 30.16 17.47 15 629562 97 89998773
Bunion operation 30.16 17.47 42 629535 1316 89997554
Spinal stenosis 30.14 17.47 216 629361 17208 89981662
Autoimmune thyroiditis 30.10 17.47 3 629574 5890 89992980
Needle issue 29.72 17.47 182 629395 13752 89985118
Pathological fracture 29.64 17.47 15 629562 9645 89989225
Pleural thickening 29.58 17.47 68 629509 3180 89995690
Hepatic cyst 29.57 17.47 5 629572 6563 89992307
Pyelonephritis 29.57 17.47 65 629512 21251 89977619
Anger 29.50 17.47 31 629546 13689 89985181
Product administration interrupted 29.45 17.47 26 629551 12466 89986404
Iron deficiency 29.38 17.47 15 629562 9597 89989273
Laryngeal oedema 29.35 17.47 6 629571 6875 89991995
Dysphoria 29.28 17.47 4 629573 6150 89992720
Mean cell volume decreased 29.24 17.47 83 629494 4423 89994447
Skin hyperpigmentation 29.17 17.47 6 629571 6845 89992025
Metastasis 29.17 17.47 4 629573 6133 89992737
Visual field defect 29.05 17.47 7 629570 7159 89991711
Staphylococcal bacteraemia 28.93 17.47 8 629569 7461 89991409
Ear pruritus 28.88 17.47 6 629571 6797 89992073
Brain injury 28.67 17.47 9 629568 7729 89991141
Immunosuppression 28.63 17.47 25 629552 12052 89986818
Catheter site infection 28.56 17.47 3 629574 5651 89993219
Product availability issue 28.55 17.47 8 629569 7396 89991474
Lymphoedema 28.54 17.47 32 629545 13721 89985149
Ocular discomfort 28.35 17.47 5 629572 6365 89992505
Sensation of foreign body 28.33 17.47 5 629572 6361 89992509
Left ventricular failure 28.25 17.47 6 629571 6694 89992176
Product label confusion 28.03 17.47 262 629315 22588 89976282
Organising pneumonia 27.86 17.47 9 629568 7588 89991282
Decreased activity 27.83 17.47 11 629566 8181 89990689
Cystitis haemorrhagic 27.66 17.47 3 629574 5510 89993360
Expired product administered 27.60 17.47 7 629570 6915 89991955
Renal function test abnormal 27.30 17.47 8 629569 7183 89991687
Myasthenia gravis 27.02 17.47 7 629570 6818 89992052
Clostridium test positive 26.94 17.47 3 629574 5398 89993472
Intracranial pressure increased 26.94 17.47 7 629570 6804 89992066
Mean cell haemoglobin decreased 26.91 17.47 94 629483 5601 89993269
Urosepsis 26.85 17.47 68 629509 21164 89977706
Retinal haemorrhage 26.83 17.47 4 629573 5760 89993110
Gastrointestinal pain 26.81 17.47 23 629554 11183 89987687
Lung neoplasm malignant 26.80 17.47 83 629494 24190 89974680
Peroneal nerve palsy 26.73 17.47 4 629573 5744 89993126
Peripheral vascular disorder 26.63 17.47 6 629571 6425 89992445
Parosmia 26.59 17.47 8 629569 7061 89991809
Immune thrombocytopenia 26.58 17.47 32 629545 13294 89985576
Haemorrhoidal haemorrhage 26.44 17.47 3 629574 5320 89993550
Cerebral disorder 26.39 17.47 4 629573 5690 89993180
Blood iron decreased 26.39 17.47 53 629524 17906 89980964
Blood magnesium increased 26.38 17.47 67 629510 3341 89995529
Shoulder arthroplasty 26.32 17.47 76 629501 4090 89994780
Extrasystoles 26.16 17.47 4 629573 5653 89993217
Ligament sprain 26.12 17.47 38 629539 14561 89984309
Bedridden 26.11 17.47 159 629418 11989 89986881
Cerebral atrophy 26.09 17.47 4 629573 5642 89993228
Vasculitic rash 26.08 17.47 40 629537 1370 89997500
Supraventricular extrasystoles 26.02 17.47 3 629574 5254 89993616
Impaired work ability 25.96 17.47 226 629351 19100 89979770
Oral herpes 25.95 17.47 132 629445 33392 89965478
Essential hypertension 25.93 17.47 6 629571 6309 89992561
Ketoacidosis 25.77 17.47 4 629573 5591 89993279
Femoral neck fracture 25.73 17.47 20 629557 10213 89988657
Injection site discomfort 25.71 17.47 5 629572 5935 89992935
Pain assessment 25.64 17.47 10 629567 32 89998838
Rash pustular 25.45 17.47 12 629565 8037 89990833
Venous thrombosis 25.41 17.47 4 629573 5533 89993337
Iron deficiency anaemia 25.36 17.47 82 629495 23580 89975290
Glucose tolerance impaired 25.10 17.47 12 629565 7973 89990897
Eye discharge 25.07 17.47 13 629564 8245 89990625
Fibrin D dimer increased 24.93 17.47 4 629573 5456 89993414
Blood glucose fluctuation 24.92 17.47 3 629574 5080 89993790
Meningioma 24.84 17.47 3 629574 5068 89993802
Pregnancy with contraceptive device 24.81 17.47 3 629574 5063 89993807
Bladder disorder 24.70 17.47 23 629554 10749 89988121
Bipolar disorder 24.64 17.47 16 629561 8969 89989901
Varicose vein 24.63 17.47 10 629567 7317 89991553
Infusion site haemorrhage 24.63 17.47 4 629573 5407 89993463
Respiratory syncytial virus infection 24.48 17.47 22 629555 10458 89988412
Escherichia bacteraemia 24.46 17.47 5 629572 5730 89993140
Cheilitis 24.43 17.47 3 629574 5004 89993866
Ear discomfort 24.32 17.47 21 629556 10179 89988691
Maternal exposure timing unspecified 24.27 17.47 251 629326 22232 89976638
Incoherent 24.24 17.47 3 629574 4974 89993896
Upper respiratory tract infection 24.23 17.47 1107 628470 127211 89871659
Post transplant lymphoproliferative disorder 24.16 17.47 9 629568 6940 89991930
Blood pressure systolic abnormal 24.16 17.47 63 629514 19415 89979455
Generalised oedema 24.11 17.47 61 629516 18992 89979878
SARS-CoV-2 test positive 24.08 17.47 25 629552 11103 89987767
Device use error 24.04 17.47 10 629567 7211 89991659
Aortic valve incompetence 24.02 17.47 8 629569 6616 89992254
Feeling of body temperature change 23.94 17.47 5 629572 5644 89993226
Cardiac failure chronic 23.92 17.47 5 629572 5641 89993229
Muscular weakness 23.91 17.47 1182 628395 205484 89793386
Ischaemia 23.91 17.47 4 629573 5291 89993579
Mucous stools 23.76 17.47 4 629573 5267 89993603
Odynophagia 23.60 17.47 17 629560 9026 89989844
Paralysis 23.50 17.47 27 629550 11451 89987419
Oesophageal candidiasis 23.48 17.47 9 629568 6820 89992050
Injection site extravasation 23.48 17.47 17 629560 9002 89989868
Dry throat 23.48 17.47 13 629564 7947 89990923
Intestinal sepsis 23.47 17.47 19 629558 311 89998559
Skin abrasion 23.47 17.47 26 629551 11209 89987661
Product preparation error 23.42 17.47 22 629555 10239 89988631
Increased tendency to bruise 23.25 17.47 29 629548 11861 89987009
Type 1 diabetes mellitus 23.20 17.47 3 629574 4809 89994061
Scab 23.20 17.47 20 629557 9701 89989169
Dry mouth 23.11 17.47 1529 628048 182530 89816340
Cartilage atrophy 23.07 17.47 15 629562 171 89998699
Left ventricular hypertrophy 23.03 17.47 7 629570 6137 89992733
Hepatic cirrhosis 23.00 17.47 589 628988 62664 89936206
Tearfulness 22.99 17.47 3 629574 4777 89994093
Menstrual disorder 22.99 17.47 7 629570 6131 89992739
Muscle disorder 22.91 17.47 5 629572 5474 89993396
Pancreatic carcinoma 22.86 17.47 15 629562 8362 89990508
Uterine haemorrhage 22.82 17.47 3 629574 4749 89994121
Staphylococcal sepsis 22.76 17.47 19 629558 9364 89989506
Neutrophilia 22.74 17.47 6 629571 5772 89993098
Ovarian neoplasm 22.65 17.47 30 629547 895 89997975
Ankle deformity 22.61 17.47 22 629555 464 89998406
Panic reaction 22.60 17.47 3 629574 4714 89994156
Pharyngeal oedema 22.58 17.47 38 629539 13733 89985137
Haemoglobin increased 22.38 17.47 12 629565 7469 89991401
Aortic stenosis 22.38 17.47 8 629569 6328 89992542
Sinus pain 22.37 17.47 5 629572 5384 89993486
Blood folate decreased 22.36 17.47 41 629536 1629 89997241
Antibody test positive 22.34 17.47 58 629519 2931 89995939
Musculoskeletal discomfort 22.32 17.47 73 629504 20918 89977952
Galactorrhoea 22.31 17.47 3 629574 4669 89994201
Colitis ulcerative 22.19 17.47 290 629287 59976 89938894
Hepatic lesion 22.12 17.47 6 629571 5667 89993203
Clostridial infection 22.09 17.47 3 629574 4633 89994237
Aortic arteriosclerosis 22.02 17.47 13 629564 7671 89991199
Pain in jaw 21.93 17.47 220 629357 47765 89951105
Hysterectomy 21.88 17.47 29 629548 11555 89987315
Depressive symptom 21.75 17.47 5 629572 5280 89993590
Bowel movement irregularity 21.72 17.47 9 629568 6505 89992365
Streptococcal infection 21.59 17.47 12 629565 7321 89991549
Macular oedema 21.53 17.47 4 629573 4905 89993965
Blindness transient 21.50 17.47 3 629574 4540 89994330
Gastrointestinal sounds abnormal 21.50 17.47 3 629574 4540 89994330
Device difficult to use 21.49 17.47 57 629520 17468 89981402
Pneumonia fungal 21.45 17.47 11 629566 7020 89991850
Skin lesion 21.21 17.47 162 629415 37203 89961667
Wound dehiscence 21.17 17.47 7 629570 5815 89993055
Skin tightness 21.16 17.47 3 629574 4485 89994385
Aphonia 21.13 17.47 33 629544 12286 89986584
Injection site nodule 21.06 17.47 3 629574 4470 89994400
Appendicitis 21.02 17.47 24 629553 10207 89988663
Hydrocephalus 21.01 17.47 8 629569 6086 89992784
Sleep terror 21.00 17.47 3 629574 4461 89994409
Anaphylactic shock 20.95 17.47 131 629446 31486 89967384
Atrioventricular block second degree 20.93 17.47 3 629574 4449 89994421
Oropharyngeal discomfort 20.91 17.47 14 629563 7721 89991149
Injection site haematoma 20.86 17.47 11 629566 6911 89991959
Deafness 20.82 17.47 83 629494 22431 89976439
Bone cyst 20.80 17.47 49 629528 2329 89996541
Uterine leiomyoma 20.72 17.47 27 629550 10837 89988033
Phlebitis 20.69 17.47 13 629564 7417 89991453
Incorrect product administration duration 20.68 17.47 67 629510 19255 89979615
Decreased interest 20.65 17.47 3 629574 4404 89994466
Tooth extraction 20.56 17.47 30 629547 11483 89987387
Injection site irritation 20.56 17.47 8 629569 6007 89992863
Hypertransaminasaemia 20.54 17.47 50 629527 15775 89983095
Neurological symptom 20.46 17.47 11 629566 6836 89992034
Oesophageal pain 20.44 17.47 3 629574 4371 89994499
Accident 20.35 17.47 99 629478 6855 89992015
Hypertonic bladder 20.28 17.47 3 629574 4345 89994525
Mouth swelling 20.25 17.47 7 629570 5655 89993215
Extremity contracture 20.24 17.47 34 629543 1259 89997611
Polycystic ovaries 20.21 17.47 7 629570 5647 89993223
Fracture treatment 20.18 17.47 11 629566 88 89998782
Hair texture abnormal 20.17 17.47 4 629573 4683 89994187
Gastric ulcer 20.17 17.47 110 629467 27338 89971532
Skin papilloma 20.09 17.47 85 629492 5545 89993325
Duodenal ulcer 20.07 17.47 22 629555 9530 89989340
Hypoxic-ischaemic encephalopathy 20.06 17.47 4 629573 4664 89994206
Vitamin B12 decreased 19.99 17.47 6 629571 5304 89993566
Anal fistula 19.98 17.47 3 629574 4298 89994572
Cardiac flutter 19.88 17.47 4 629573 4634 89994236
Sarcoidosis 19.87 17.47 27 629550 10646 89988224
Investigation abnormal 19.87 17.47 47 629530 2240 89996630
Performance status decreased 19.85 17.47 3 629574 4277 89994593
Coronary artery stenosis 19.74 17.47 6 629571 5260 89993610
Renal pain 19.72 17.47 15 629562 7744 89991126
Urine abnormality 19.61 17.47 15 629562 7722 89991148
Anxiety disorder 19.58 17.47 5 629572 4917 89993953
Meningitis 19.57 17.47 18 629559 8463 89990407
Product prescribing issue 19.55 17.47 16 629561 7963 89990907
Bacterial test positive 19.55 17.47 7 629570 5532 89993338
Allergy to chemicals 19.54 17.47 64 629513 3690 89995180
Injection site reaction 19.53 17.47 804 628773 91276 89907594
Lumbar vertebral fracture 19.49 17.47 14 629563 7444 89991426
Cholangitis 19.41 17.47 13 629564 7169 89991701
Nerve injury 19.40 17.47 138 629439 10968 89987902
Scoliosis 19.29 17.47 20 629557 8887 89989983
Cardiopulmonary failure 19.28 17.47 3 629574 4185 89994685
Carotid artery occlusion 19.23 17.47 10 629567 6332 89992538
Drug dependence 19.18 17.47 122 629455 29205 89969665
Crohn's disease 19.16 17.47 5 629572 4846 89994024
Pain in extremity 19.11 17.47 3481 626096 447048 89551822
Product dispensing error 19.10 17.47 35 629542 12238 89986632
Type I hypersensitivity 19.07 17.47 3 629574 4152 89994718
Wrist fracture 19.02 17.47 51 629526 15573 89983297
Neutropenic colitis 19.00 17.47 3 629574 4140 89994730
Enthesopathy 18.91 17.47 121 629456 9283 89989587
Pulmonary pain 18.86 17.47 6 629571 5108 89993762
Vitamin D decreased 18.79 17.47 34 629543 11945 89986925
Chest X-ray abnormal 18.67 17.47 6 629571 5076 89993794
Internal haemorrhage 18.58 17.47 10 629567 6210 89992660
Ulcer haemorrhage 18.48 17.47 271 629306 26050 89972820
Nervous system disorder 18.48 17.47 82 629495 21511 89977359
Lung neoplasm 18.46 17.47 12 629565 6723 89992147
Ventricular hypokinesia 18.43 17.47 7 629570 5334 89993536
Pharyngitis 18.39 17.47 84 629493 21863 89977007
Vasculitis 18.34 17.47 88 629489 22605 89976265
Portal hypertension 18.27 17.47 5 629572 4696 89994174
Blood potassium increased 18.25 17.47 78 629499 20671 89978199
Photosensitivity reaction 18.20 17.47 63 629514 17744 89981126
Vulvovaginal pruritus 18.07 17.47 3 629574 3990 89994880
Spinal meningioma benign 18.04 17.47 11 629566 111 89998759
Thyroid function test abnormal 18.04 17.47 3 629574 3986 89994884
Nasal discomfort 17.96 17.47 8 629569 5540 89993330
Facial paresis 17.88 17.47 3 629574 3960 89994910
Papilloedema 17.77 17.47 5 629572 4610 89994260
Incorrect drug administration rate 17.77 17.47 7 629570 5216 89993654
Pneumonia bacterial 17.74 17.47 39 629538 12751 89986119
Post procedural complication 17.73 17.47 70 629507 18972 89979898
Breast cancer recurrent 17.72 17.47 8 629569 5495 89993375
Synovial cyst 17.69 17.47 141 629436 11611 89987259
Pharyngeal swelling 17.67 17.47 26 629551 9918 89988952
Pruritus 17.66 17.47 4131 625446 537394 89461476
Rheumatic disorder 17.65 17.47 58 629519 3350 89995520
Retinal detachment 17.58 17.47 13 629564 6809 89992061
Rhinitis 17.53 17.47 43 629534 13529 89985341

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Joint swelling 3253.83 20.65 1561 46138 66461 42507175
Drug ineffective 1967.83 20.65 2907 44792 627290 41946346
Contraindicated product administered 1637.46 20.65 718 46981 24554 42549082
Arthralgia 1540.68 20.65 1489 46210 203749 42369887
Synovitis 1098.24 20.65 470 47229 15097 42558539
Rheumatoid arthritis 1005.75 20.65 613 47086 41827 42531809
Drug intolerance 898.67 20.65 733 46966 79691 42493945
Pain 791.82 20.65 1157 46542 243691 42329945
Treatment failure 780.87 20.65 609 47090 62015 42511621
Arthropathy 756.39 20.65 449 47250 29148 42544488
Apparent death 702.16 20.65 231 47468 3477 42570159
C-reactive protein abnormal 694.01 20.65 292 47407 8969 42564667
Bone erosion 546.02 20.65 200 47499 4203 42569433
Therapeutic product effect decreased 496.75 20.65 385 47314 38765 42534871
Drug hypersensitivity 496.37 20.65 583 47116 98806 42474830
Diverticulitis 470.92 20.65 302 47397 22471 42551165
Red blood cell sedimentation rate abnormal 384.01 20.65 149 47550 3687 42569949
Loss of personal independence in daily activities 309.79 20.65 328 47371 49488 42524148
Musculoskeletal stiffness 288.18 20.65 339 47360 57426 42516210
Acute kidney injury 272.45 20.65 43 47656 367294 42206342
Mobility decreased 260.49 20.65 255 47444 35051 42538585
Hand deformity 256.35 20.65 111 47588 3657 42569979
Drug interaction 236.81 20.65 16 47683 266983 42306653
Osteoarthritis 231.83 20.65 203 47496 24202 42549434
Red blood cell sedimentation rate increased 228.60 20.65 141 47558 9783 42563853
Pulmonary thrombosis 227.07 20.65 132 47567 8216 42565420
Rheumatoid factor negative 223.86 20.65 71 47628 943 42572693
Knee arthroplasty 223.48 20.65 133 47566 8648 42564988
Chondropathy 218.89 20.65 73 47626 1147 42572489
Disability 211.20 20.65 112 47587 5821 42567815
Drug tolerance decreased 209.32 20.65 84 47615 2276 42571360
Device safety feature issue 198.34 20.65 36 47663 12 42573624
Tenosynovitis 194.08 20.65 98 47601 4597 42569039
Peripheral swelling 191.59 20.65 354 47345 89916 42483720
Herpes zoster 190.21 20.65 226 47473 38651 42534985
Hypotension 188.89 20.65 31 47668 257600 42316036
Terminal state 184.82 20.65 93 47606 4330 42569306
Toxicity to various agents 178.55 20.65 23 47676 229113 42344523
Febrile neutropenia 174.19 20.65 8 47691 185695 42387941
C-reactive protein increased 167.08 20.65 274 47425 63286 42510350
Sarcoidosis 161.46 20.65 80 47619 3602 42570034
Alanine aminotransferase abnormal 158.30 20.65 87 47612 4857 42568779
Arthritis 155.89 20.65 213 47486 41852 42531784
Device malfunction 153.49 20.65 120 47579 12207 42561429
Lymphoma 152.03 20.65 127 47572 14194 42559442
Onychoclasis 151.10 20.65 69 47630 2583 42571053
Enthesopathy 146.48 20.65 82 47617 4746 42568890
Dislocation of vertebra 140.72 20.65 41 47658 400 42573236
Mineral metabolism disorder 139.10 20.65 40 47659 371 42573265
Therapy interrupted 137.29 20.65 146 47553 22104 42551532
Atlantoaxial instability 136.31 20.65 40 47659 401 42573235
Acne cystic 133.66 20.65 42 47657 540 42573096
Tongue disorder 132.98 20.65 80 47619 5303 42568333
Deep vein thrombosis 131.93 20.65 276 47423 76681 42496955
Limb discomfort 130.95 20.65 111 47588 12656 42560980
Tooth fracture 129.50 20.65 72 47627 4112 42569524
Anaemia 129.11 20.65 77 47622 280201 42293435
Impaired work ability 127.88 20.65 107 47592 11984 42561652
Drug specific antibody present 126.90 20.65 70 47629 3936 42569700
Pyrexia 125.84 20.65 154 47545 393888 42179748
Adverse event 124.89 20.65 143 47556 23497 42550139
Tooth loss 124.52 20.65 70 47629 4084 42569552
Spinal instability 123.33 20.65 40 47659 573 42573063
Joint arthroplasty 119.69 20.65 44 47655 933 42572703
Gait inability 117.06 20.65 136 47563 22697 42550939
Thrombocytopenia 116.91 20.65 34 47665 190245 42383391
Localised infection 114.03 20.65 127 47572 20246 42553390
Rheumatoid factor positive 111.64 20.65 40 47659 786 42572850
Product storage error 110.46 20.65 95 47604 11045 42562591
Abdominal pain 109.96 20.65 38 47661 190433 42383203
Musculoskeletal pain 108.95 20.65 159 47540 33181 42540455
Gastric disorder 108.84 20.65 97 47602 11825 42561811
Confusional state 108.50 20.65 27 47672 167570 42406066
Diarrhoea 108.38 20.65 221 47478 460628 42113008
Vomiting 108.32 20.65 99 47600 289624 42284012
Intestinal sepsis 107.69 20.65 38 47661 713 42572923
Skin ulcer 106.15 20.65 137 47562 25464 42548172
Drug abuse 103.39 20.65 3 47696 104768 42468868
Infection 99.04 20.65 313 47386 111755 42461881
Intervertebral disc space narrowing 98.93 20.65 40 47659 1105 42572531
Dehydration 95.39 20.65 21 47678 141746 42431890
Decreased appetite 94.72 20.65 49 47650 193088 42380548
Malignant neoplasm progression 94.48 20.65 7 47692 108393 42465243
Dyspnoea 93.56 20.65 225 47474 442396 42131240
Osteosclerosis 91.61 20.65 41 47658 1463 42572173
Disease progression 91.32 20.65 24 47675 143632 42430004
Hyponatraemia 90.03 20.65 6 47693 101456 42472180
Swelling 88.43 20.65 192 47507 54693 42518943
Somnolence 87.02 20.65 25 47674 141080 42432556
Urticaria 86.89 20.65 229 47470 73807 42499829
Photosensitivity reaction 86.70 20.65 88 47611 12614 42561022
Device delivery system issue 85.40 20.65 35 47664 1002 42572634
X-ray abnormal 85.38 20.65 29 47670 483 42573153
Blood creatinine increased 83.30 20.65 12 47687 109991 42463645
Intestinal polyp 83.07 20.65 37 47662 1305 42572331
Interstitial lung disease 82.41 20.65 233 47466 78229 42495407
Overdose 80.84 20.65 11 47688 105253 42468383
Sleep disorder due to general medical condition, insomnia type 79.87 20.65 37 47662 1432 42572204
Polyarthritis 79.87 20.65 57 47642 5047 42568589
Seizure 78.82 20.65 19 47680 120542 42453094
Ill-defined disorder 78.44 20.65 94 47605 16202 42557434
Pain in extremity 77.61 20.65 354 47345 150250 42423386
Skin laceration 77.57 20.65 87 47612 13971 42559665
Hyperkalaemia 76.92 20.65 3 47696 80455 42493181
Rhabdomyolysis 74.28 20.65 3 47696 78016 42495620
Constipation 74.03 20.65 45 47654 162246 42411390
Device operational issue 72.72 20.65 22 47677 247 42573389
Tachycardia 72.11 20.65 13 47686 101074 42472562
Loss of therapeutic response 71.70 20.65 33 47666 1258 42572378
Gastrointestinal disorder 71.51 20.65 160 47539 46493 42527143
Joint stiffness 70.99 20.65 78 47621 12244 42561392
Neoplasm malignant 70.74 20.65 106 47593 22637 42550999
Tendonitis 70.19 20.65 70 47629 9824 42563812
Rheumatoid lung 68.72 20.65 29 47670 895 42572741
Alopecia 68.62 20.65 120 47579 29156 42544480
C-reactive protein decreased 67.89 20.65 38 47661 2198 42571438
Anxiety 67.77 20.65 24 47675 118536 42455100
Rheumatoid nodule 67.55 20.65 42 47657 2953 42570683
Hypokalaemia 67.47 20.65 3 47696 71718 42501918
Hepatitis B virus test positive 67.02 20.65 22 47677 328 42573308
Physical disability 65.64 20.65 35 47664 1838 42571798
Joint lock 63.43 20.65 31 47668 1354 42572282
Cardiac arrest 61.01 20.65 23 47676 109297 42464339
Intentional product use issue 61.01 20.65 198 47501 71635 42502001
Bradycardia 60.95 20.65 11 47688 85473 42488163
Pulmonary embolism 60.72 20.65 280 47419 119332 42454304
Joint range of motion decreased 59.00 20.65 57 47642 7696 42565940
Fracture 58.72 20.65 58 47641 8045 42565591
Bone cyst 58.28 20.65 31 47668 1620 42572016
Dizziness 57.99 20.65 120 47579 249134 42324502
Fatigue 57.89 20.65 271 47428 435370 42138266
Seronegative arthritis 57.87 20.65 28 47671 1196 42572440
Joint ankylosis 57.82 20.65 31 47668 1646 42571990
Renal impairment 55.44 20.65 27 47672 110201 42463435
Oral surgery 54.95 20.65 22 47677 592 42573044
Musculoskeletal discomfort 54.61 20.65 60 47639 9416 42564220
Anti-cyclic citrullinated peptide antibody positive 54.02 20.65 31 47668 1881 42571755
Oral disorder 53.82 20.65 44 47655 4768 42568868
Neutropenia 53.48 20.65 88 47611 199343 42374293
Cardio-respiratory arrest 53.41 20.65 3 47696 58633 42515003
Hepatic cirrhosis 53.14 20.65 86 47613 19616 42554020
Inflammation 52.89 20.65 117 47582 33730 42539906
Immobile 51.95 20.65 35 47664 2823 42570813
Hypoglycaemia 51.75 20.65 4 47695 59850 42513786
Blood glucose increased 51.44 20.65 10 47689 73689 42499947
Intentional product misuse 51.18 20.65 5 47694 61895 42511741
Agitation 51.11 20.65 6 47693 64308 42509328
Therapeutic product effect incomplete 51.01 20.65 185 47514 70754 42502882
Granuloma skin 49.95 20.65 25 47674 1150 42572486
Neuropathy peripheral 49.64 20.65 26 47673 101827 42471809
Headache 49.57 20.65 446 47253 238923 42334713
Fine motor skill dysfunction 49.49 20.65 31 47668 2208 42571428
Pancytopenia 49.16 20.65 36 47663 117707 42455929
Red blood cell sedimentation rate 48.94 20.65 24 47675 1056 42572580
Tooth extraction 48.85 20.65 44 47655 5436 42568200
Liver function test increased 48.20 20.65 83 47616 19915 42553721
Stent placement 47.71 20.65 43 47656 5317 42568319
Surgery 47.66 20.65 77 47622 17539 42556097
Gastrointestinal haemorrhage 47.55 20.65 25 47674 97701 42475935
Haematuria 46.92 20.65 5 47694 57794 42515842
Drug use disorder 45.51 20.65 57 47642 10276 42563360
Vitamin D deficiency 44.60 20.65 50 47649 8023 42565613
Abdominal distension 43.66 20.65 13 47686 71722 42501914
Product use in unapproved indication 43.55 20.65 88 47611 184368 42389268
Ascites 43.32 20.65 6 47693 56672 42516964
Respiratory failure 42.96 20.65 48 47651 128084 42445552
International normalised ratio increased 42.27 20.65 3 47696 48165 42525471
Renal failure 41.96 20.65 290 47409 143436 42430200
Tooth disorder 41.86 20.65 59 47640 11920 42561716
Skin mass 41.62 20.65 38 47661 4778 42568858
Loss of consciousness 41.54 20.65 26 47673 92328 42481308
Delirium 41.49 20.65 5 47694 52514 42521122
Erythema 41.42 20.65 235 47464 108558 42465078
Multiple organ dysfunction syndrome 41.37 20.65 29 47670 97006 42476630
Platelet count decreased 41.14 20.65 57 47642 138524 42435112
Skin cancer 40.86 20.65 57 47642 11405 42562231
Panniculitis 40.34 20.65 27 47672 2154 42571482
Upper respiratory tract infection 40.17 20.65 121 47578 42052 42531584
Foot deformity 39.96 20.65 38 47661 5030 42568606
Blood parathyroid hormone decreased 39.50 20.65 24 47675 1619 42572017
Syncope 39.44 20.65 32 47667 99374 42474262
Food intolerance 39.33 20.65 24 47675 1632 42572004
Spinal cord injury cervical 38.75 20.65 14 47685 282 42573354
Osteolysis 38.51 20.65 32 47667 3548 42570088
Malignant melanoma 38.47 20.65 50 47649 9350 42564286
Nephrolithiasis 38.27 20.65 109 47590 36721 42536915
Gastrointestinal infection 37.66 20.65 42 47657 6701 42566935
Thrombosis 36.69 20.65 163 47536 68348 42505288
Angioedema 36.27 20.65 3 47696 42474 42531162
Hepatic function abnormal 35.97 20.65 7 47692 51560 42522076
Skin injury 35.69 20.65 27 47672 2614 42571022
Immobilisation syndrome 35.60 20.65 15 47684 461 42573175
Diabetes mellitus 35.28 20.65 147 47552 59940 42513696
Lymphoedema 35.08 20.65 35 47664 4913 42568723
Soft tissue swelling 34.64 20.65 17 47682 749 42572887
Pneumonia aspiration 34.51 20.65 7 47692 50071 42523565
Hallucination 33.96 20.65 11 47688 57496 42516140
Device defective 33.90 20.65 22 47677 1666 42571970
Aggression 32.99 20.65 5 47694 44158 42529478
Blood pressure decreased 32.99 20.65 12 47687 58320 42515316
Suicidal ideation 32.63 20.65 7 47692 48154 42525482
Encephalopathy 32.48 20.65 4 47695 41329 42532307
Dyspepsia 32.43 20.65 111 47588 41241 42532395
Dysphagia 31.97 20.65 21 47678 72698 42500938
Injection related reaction 31.89 20.65 15 47684 601 42573035
Hepatic fibrosis 31.88 20.65 33 47666 4839 42568797
Haemorrhage 31.73 20.65 14 47685 60549 42513087
Shoulder operation 31.72 20.65 20 47679 1441 42572195
White blood cell count increased 31.70 20.65 6 47693 45081 42528555
Abdominal discomfort 31.61 20.65 167 47532 75088 42498548
Asthenia 31.41 20.65 185 47514 280608 42293028
Muscle spasms 31.35 20.65 30 47669 86014 42487622
Hip arthroplasty 31.28 20.65 34 47665 5271 42568365
Hepatic steatosis 31.12 20.65 72 47627 21376 42552260
Therapy non-responder 30.90 20.65 130 47569 53229 42520407
Insurance issue 30.83 20.65 30 47669 4086 42569550
Fibromyalgia 30.21 20.65 29 47670 3884 42569752
Cerebral haemorrhage 30.07 20.65 4 47695 38962 42534674
Myalgia 30.05 20.65 38 47661 96042 42477594
Psoriatic arthropathy 30.04 20.65 78 47621 24889 42548747
Gingivitis ulcerative 29.93 20.65 11 47688 233 42573403
Chronic kidney disease 29.78 20.65 8 47691 47233 42526403
Wheezing 29.76 20.65 12 47687 54769 42518867
Rheumatoid factor increased 29.75 20.65 15 47684 701 42572935
Hypersensitivity 29.31 20.65 159 47540 72211 42501425
Blood pressure systolic increased 29.27 20.65 83 47616 27885 42545751
Back disorder 29.25 20.65 39 47660 7475 42566161
Haemoptysis 28.76 20.65 8 47691 46159 42527477
Prostate cancer 28.41 20.65 112 47587 44531 42529105
Lesion excision 28.07 20.65 7 47692 35 42573601
Rheumatoid factor 27.84 20.65 8 47691 74 42573562
Lung neoplasm malignant 27.48 20.65 64 47635 19083 42554553
Epistaxis 27.15 20.65 21 47678 66805 42506831
Illness 27.09 20.65 75 47624 24855 42548781
Nodular regenerative hyperplasia 26.99 20.65 16 47683 1032 42572604
Plasma cell myeloma 26.54 20.65 10 47689 47568 42526068
Nodule 26.33 20.65 49 47650 12485 42561151
Basal cell carcinoma 26.31 20.65 70 47629 22663 42550973
Death 26.13 20.65 371 47328 470814 42102822
Anal squamous cell carcinoma 25.95 20.65 9 47690 160 42573476
Jaundice 25.64 20.65 4 47695 34585 42539051
Dysgeusia 25.24 20.65 4 47695 34185 42539451
Stress 25.16 20.65 9 47690 44203 42529433
Urinary retention 25.05 20.65 8 47691 42206 42531430
Dental caries 24.92 20.65 29 47670 4843 42568793
Atrial fibrillation 24.81 20.65 77 47622 139516 42434120
Mass 24.73 20.65 39 47660 8700 42564936
Foetal exposure during pregnancy 24.68 20.65 11 47688 47300 42526336
Periorbital infection 24.52 20.65 9 47690 190 42573446
Medication error 24.21 20.65 4 47695 33150 42540486
Upper gastrointestinal haemorrhage 23.64 20.65 3 47696 30296 42543340
Melaena 23.61 20.65 7 47692 38739 42534897
Nasopharyngitis 23.61 20.65 168 47531 83828 42489808
Hypoxia 23.53 20.65 26 47673 69760 42503876
Myelosuppression 23.43 20.65 8 47691 40453 42533183
Disorientation 23.25 20.65 6 47693 36383 42537253
Skin neoplasm excision 23.24 20.65 11 47688 447 42573189
Disturbance in attention 23.20 20.65 3 47696 29863 42543773
Septic shock 23.12 20.65 42 47657 91630 42482006
Pulmonary fibrosis 23.04 20.65 74 47625 26607 42547029
Lethargy 22.79 20.65 12 47687 46878 42526758
Stomatitis 22.74 20.65 114 47585 50215 42523421
C-reactive protein 22.71 20.65 7 47692 84 42573552
Eosinophilia 21.85 20.65 5 47694 32894 42540742
Lymphoplasmacytoid lymphoma/immunocytoma 21.65 20.65 6 47693 48 42573588
Oedema 21.56 20.65 16 47683 51985 42521651
Reactive gastropathy 20.87 20.65 11 47688 564 42573072

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Joint swelling 12199.57 18.32 12462 498865 430383 109647589
Arthralgia 6823.93 18.32 12577 498750 767055 109310917
Contraindicated product administered 5257.81 18.32 6098 505229 242169 109835803
Synovitis 4325.94 18.32 5811 505516 268281 109809691
Drug ineffective 4033.72 18.32 15718 495609 1504822 108573150
Drug intolerance 3724.98 18.32 6705 504622 399807 109678165
Arthropathy 3259.90 18.32 5217 506110 282305 109795667
Treatment failure 2900.85 18.32 4852 506475 272382 109805590
Pain 2674.40 18.32 10064 501263 944891 109133081
Therapeutic product effect decreased 2509.91 18.32 4242 507085 240074 109837898
Acute kidney injury 2282.55 18.32 173 511154 635257 109442715
Hand deformity 2212.23 18.32 3770 507557 214736 109863236
Pemphigus 1908.18 18.32 3498 507829 211072 109866900
Systemic lupus erythematosus 1901.39 18.32 3852 507475 250486 109827486
Swelling 1822.68 18.32 4599 506728 346442 109731530
Glossodynia 1817.09 18.32 3493 507834 218511 109859461
Drug interaction 1708.66 18.32 168 511159 500015 109577957
Hepatic enzyme increased 1673.82 18.32 4212 507115 316680 109761292
C-reactive protein abnormal 1642.42 18.32 2479 508848 127216 109950756
Anti-cyclic citrullinated peptide antibody positive 1601.47 18.32 2954 508373 179030 109898942
Anaemia 1594.81 18.32 300 511027 546786 109531186
Therapy interrupted 1593.20 18.32 1527 509800 48295 110029677
Hypersensitivity 1577.19 18.32 4769 506558 399229 109678743
Rheumatoid factor positive 1522.44 18.32 2413 508914 129227 109948745
Hypotension 1493.67 18.32 303 511024 523546 109554426
Toxicity to various agents 1490.17 18.32 223 511104 480332 109597640
Wound 1434.84 18.32 3275 508052 231162 109846810
Pericarditis 1414.78 18.32 3127 508200 215987 109861985
Febrile neutropenia 1352.30 18.32 22 511305 316745 109761227
Alopecia 1323.09 18.32 4198 507129 360555 109717417
Red blood cell sedimentation rate abnormal 1315.65 18.32 1011 510316 23498 110054474
Helicobacter infection 1283.33 18.32 2691 508636 179186 109898786
Abdominal discomfort 1234.63 18.32 4315 507012 389543 109688429
Duodenal ulcer perforation 1183.11 18.32 2568 508759 175132 109902840
Irritable bowel syndrome 1125.14 18.32 2401 508926 161814 109916158
Rheumatoid arthritis 1109.53 18.32 3474 507853 296139 109781833
Impaired healing 1108.16 18.32 2661 508666 194056 109883916
Folliculitis 1102.59 18.32 2411 508916 165242 109912730
Completed suicide 1101.14 18.32 3 511324 242378 109835594
Musculoskeletal stiffness 1063.32 18.32 3274 508053 276548 109801424
Drug hypersensitivity 1058.92 18.32 4530 506797 449560 109628412
Muscle injury 1050.26 18.32 2132 509195 138675 109939297
Infection 1040.12 18.32 3857 507470 358343 109719629
Peripheral swelling 1019.67 18.32 4130 507197 399904 109678068
Death 973.37 18.32 1079 510248 697790 109380182
Neutropenia 934.85 18.32 285 511042 374335 109703637
Sleep disorder due to general medical condition, insomnia type 917.53 18.32 1706 509621 103937 109974035
Mobility decreased 891.57 18.32 2767 508560 234655 109843317
Infusion related reaction 883.07 18.32 3796 507531 377366 109700606
Ill-defined disorder 852.35 18.32 2093 509234 154760 109923212
Somnolence 851.32 18.32 170 511157 297279 109780693
Adverse event 842.91 18.32 1674 509653 107135 109970837
Discomfort 821.60 18.32 2519 508808 212188 109865784
Fibromyalgia 801.02 18.32 2157 509170 168752 109909220
Blister 799.74 18.32 2591 508736 224785 109853187
Lower respiratory tract infection 790.79 18.32 2698 508629 240408 109837564
Sinusitis 783.37 18.32 3077 508250 293611 109784361
Dehydration 782.84 18.32 168 511159 279343 109798629
Drug abuse 780.59 18.32 7 511320 177404 109900568
Malignant neoplasm progression 767.53 18.32 7 511320 174560 109903412
Hyponatraemia 764.14 18.32 65 511262 217588 109860384
Rheumatic fever 748.62 18.32 1712 509615 120867 109957105
Disease progression 742.65 18.32 119 511208 243915 109834057
Cardiac arrest 730.16 18.32 45 511282 196708 109881264
Seizure 727.10 18.32 85 511242 221100 109856872
Red blood cell sedimentation rate increased 724.77 18.32 1300 510027 77002 110000970
Inflammation 706.72 18.32 2232 509095 191006 109886966
Rash 699.51 18.32 6311 505016 814653 109263319
Pancytopenia 631.55 18.32 105 511222 209508 109868464
Osteoarthritis 622.15 18.32 2059 509268 180564 109897408
Respiratory failure 620.35 18.32 121 511206 215211 109862761
Stomatitis 616.54 18.32 2680 508647 267562 109810410
Bradycardia 613.93 18.32 24 511303 155493 109922479
Thrombocytopenia 597.66 18.32 444 510883 348441 109729531
Device safety feature issue 591.60 18.32 158 511169 142 110077830
Loss of personal independence in daily activities 591.35 18.32 1779 509548 148241 109929731
Joint range of motion decreased 591.28 18.32 1558 509769 120274 109957698
Constipation 590.44 18.32 473 510854 357313 109720659
Psoriatic arthropathy 588.95 18.32 2125 509202 194636 109883336
Hyperkalaemia 581.04 18.32 9 511318 135787 109942185
Maternal exposure during pregnancy 579.34 18.32 2525 508802 252358 109825614
Gastrointestinal disorder 577.73 18.32 2433 508894 239519 109838453
Tremor 567.28 18.32 121 511206 202111 109875861
Swollen joint count increased 556.25 18.32 1209 510118 82452 109995520
Dyspnoea 550.56 18.32 2944 508383 1103928 108974044
Bone erosion 549.41 18.32 860 510467 45511 110032461
Gastrointestinal haemorrhage 547.97 18.32 62 511265 165456 109912516
C-reactive protein increased 540.35 18.32 2217 509110 215702 109862270
Type 2 diabetes mellitus 535.40 18.32 1920 509407 175312 109902660
Bursitis 531.34 18.32 1561 509766 128357 109949615
Platelet count decreased 529.98 18.32 201 511126 230242 109847730
Blood cholesterol increased 523.01 18.32 1960 509367 182825 109895147
Musculoskeletal pain 521.09 18.32 1945 509382 181078 109896894
Rhabdomyolysis 519.36 18.32 7 511320 120394 109957578
Multiple organ dysfunction syndrome 506.84 18.32 55 511272 151655 109926317
Cardio-respiratory arrest 498.50 18.32 7 511320 115829 109962143
Coma 491.33 18.32 11 511316 117858 109960114
Depressed level of consciousness 486.63 18.32 6 511321 112272 109965700
Nasopharyngitis 484.37 18.32 3302 508025 391059 109686913
Electrocardiogram QT prolonged 480.70 18.32 4 511323 108956 109969016
Knee arthroplasty 464.57 18.32 967 510360 63981 110013991
General physical health deterioration 464.27 18.32 3461 507866 421834 109656138
Chest discomfort 459.87 18.32 118 511209 173730 109904242
Sepsis 454.12 18.32 506 510821 326840 109751132
Product use issue 453.01 18.32 2724 508603 308971 109769001
Facet joint syndrome 451.31 18.32 1220 510107 95608 109982364
Neutrophil count decreased 450.64 18.32 27 511300 120914 109957058
Hypoglycaemia 448.02 18.32 21 511306 116083 109961889
Tachycardia 446.05 18.32 246 511081 226399 109851573
Suicide attempt 441.71 18.32 7 511320 103387 109974585
Hypoxia 440.26 18.32 44 511283 129471 109948501
White blood cell count decreased 438.53 18.32 258 511069 229132 109848840
Dysphagia 424.46 18.32 95 511232 153505 109924467
Device operational issue 416.55 18.32 167 511160 965 110077007
Agitation 415.94 18.32 27 511300 113024 109964948
Rheumatoid nodule 415.52 18.32 491 510836 19805 110058167
Renal failure 414.84 18.32 268 511059 226306 109851666
Arthritis 412.18 18.32 1701 509626 165885 109912087
Lactic acidosis 411.41 18.32 3 511324 92808 109985164
Sciatica 410.55 18.32 1144 510183 91255 109986717
Metabolic acidosis 409.29 18.32 11 511316 99733 109978239
Sleep disorder 408.58 18.32 1911 509416 196733 109881239
Syncope 402.67 18.32 217 511110 202319 109875653
Epistaxis 400.07 18.32 62 511265 130310 109947662
Atrial fibrillation 398.61 18.32 288 511039 229354 109848618
Lip dry 397.25 18.32 1190 510137 98893 109979079
Pulmonary embolism 396.34 18.32 251 511076 214223 109863749
Hallucination 395.79 18.32 17 511310 101415 109976557
Night sweats 383.86 18.32 1427 509900 132556 109945416
Foot deformity 380.23 18.32 750 510577 47730 110030242
Haemoglobin decreased 378.37 18.32 355 510972 248372 109829600
Neuropathy peripheral 375.97 18.32 179 511148 179098 109898874
Loss of therapeutic response 372.49 18.32 197 511130 2313 110075659
Ascites 367.36 18.32 14 511313 92794 109985178
Hypokalaemia 364.85 18.32 194 511133 182254 109895718
Blood creatinine increased 363.49 18.32 196 511131 182693 109895279
International normalised ratio increased 358.18 18.32 9 511318 86763 109991209
Balance disorder 345.26 18.32 61 511266 116499 109961473
Drug reaction with eosinophilia and systemic symptoms 337.04 18.32 9 511318 82086 109995886
Hip arthroplasty 336.67 18.32 776 510551 55037 110022935
Drug tolerance decreased 336.32 18.32 518 510809 27022 110050950
Dysarthria 335.34 18.32 12 511315 84109 109993863
Peripheral venous disease 334.60 18.32 1001 510326 83116 109994856
Hyperglycaemia 332.87 18.32 14 511313 85076 109992896
Dyspnoea exertional 332.08 18.32 44 511283 104016 109973956
Coeliac disease 330.13 18.32 661 510666 42526 110035446
Encephalopathy 328.66 18.32 10 511317 81045 109996927
Liver injury 327.01 18.32 1471 509856 148942 109929030
Abdominal pain 325.67 18.32 1245 510082 511744 109566228
Haematuria 323.57 18.32 14 511313 82991 109994981
Injury 321.99 18.32 1646 509681 175619 109902353
Palpitations 321.73 18.32 167 511160 159045 109918927
Cerebrovascular accident 321.62 18.32 222 511105 181062 109896910
Hepatic function abnormal 320.74 18.32 24 511303 89271 109988701
Myalgia 319.12 18.32 334 510993 222047 109855925
Fall 318.90 18.32 1570 509757 601912 109476060
Cough 316.40 18.32 1085 510242 460556 109617416
Myelosuppression 315.60 18.32 34 511293 94306 109983666
Obesity 315.31 18.32 1196 510131 112155 109965817
Chills 314.10 18.32 252 511075 190328 109887644
Diarrhoea 310.47 18.32 3574 507753 1135931 108942041
Vision blurred 307.65 18.32 106 511221 128916 109949056
Cognitive disorder 307.40 18.32 26 511301 87485 109990487
Blood pressure decreased 306.50 18.32 77 511250 115014 109962958
Breast cancer stage III 303.88 18.32 930 510397 78187 109999785
Blood glucose increased 302.16 18.32 117 511210 132379 109945593
Grip strength decreased 300.11 18.32 934 510393 79240 109998732
Cardiac failure 286.24 18.32 267 511060 187359 109890613
Blood bilirubin increased 285.96 18.32 16 511311 75956 110002016
Injection site pain 284.87 18.32 242 511085 177680 109900292
Prescribed overdose 283.47 18.32 971 510356 86610 109991362
Renal impairment 283.00 18.32 272 511055 188173 109889799
Disability 282.40 18.32 504 510823 29719 110048253
Device delivery system issue 281.86 18.32 155 511172 1978 110075994
Gait inability 280.32 18.32 1312 510015 135064 109942908
Blood creatine phosphokinase increased 279.42 18.32 14 511313 73063 110004909
Pleural effusion 279.31 18.32 246 511081 177463 109900509
Nausea 278.13 18.32 4034 507293 1231656 108846316
Melaena 276.92 18.32 9 511318 68748 110009224
Suicidal ideation 274.24 18.32 51 511276 93886 109984086
Neoplasm progression 273.30 18.32 5 511322 64590 110013382
Cardiac failure congestive 270.40 18.32 183 511144 150817 109927155
Blood parathyroid hormone decreased 270.18 18.32 318 511009 12771 110065201
Disorientation 265.64 18.32 15 511312 70656 110007316
Granuloma skin 264.85 18.32 293 511034 10990 110066982
Unresponsive to stimuli 261.84 18.32 7 511320 63783 110014189
Panniculitis 261.23 18.32 341 510986 15241 110062731
Hepatic failure 260.20 18.32 14 511313 68725 110009247
Haemorrhage 259.00 18.32 85 511242 106607 109971365
Hypercholesterolaemia 258.88 18.32 966 510361 89871 109988101
Haematochezia 258.52 18.32 105 511222 115419 109962553
Intentional product use issue 258.05 18.32 1996 509331 245910 109832062
Overdose 255.01 18.32 430 510897 233364 109844608
Oxygen saturation decreased 250.72 18.32 214 511113 156768 109921204
Pulmonary fibrosis 250.20 18.32 1035 510292 101007 109976965
Pulmonary oedema 250.03 18.32 77 511250 100582 109977390
Urinary retention 249.50 18.32 19 511308 69664 110008308
Wound infection 248.88 18.32 994 510333 95471 109982501
Haemoptysis 248.44 18.32 22 511305 71332 110006640
Incorrect dose administered 247.35 18.32 85 511242 103556 109974416
Skin exfoliation 246.62 18.32 52 511275 87599 109990373
Lethargy 246.49 18.32 64 511263 93512 109984460
Dislocation of vertebra 246.40 18.32 592 510735 43129 110034843
Pneumonia aspiration 246.12 18.32 40 511287 81193 109996779
Angioedema 245.29 18.32 75 511252 98425 109979547
Lower limb fracture 240.02 18.32 831 510496 74517 110003455
Dysgeusia 239.86 18.32 23 511304 69962 110008010
Fracture 237.57 18.32 418 510909 24370 110053602
Acute myocardial infarction 237.16 18.32 49 511278 83728 109994244
Osteoporosis 235.32 18.32 911 510416 86241 109991731
Jaundice 234.22 18.32 9 511318 59227 110018745
Therapeutic product effect incomplete 234.04 18.32 1804 509523 222001 109855971
Blood alkaline phosphatase increased 233.65 18.32 27 511300 70908 110007064
Aphasia 229.79 18.32 10 511317 58987 110018985
Deep vein thrombosis postoperative 229.59 18.32 699 510628 58592 110019380
Disturbance in attention 227.46 18.32 15 511312 61980 110015992
Vomiting 225.69 18.32 2914 508413 907761 109170211
Dry skin 224.88 18.32 108 511219 107545 109970427
Tenosynovitis 224.21 18.32 324 511003 15959 110062013
Haematemesis 223.85 18.32 12 511315 59096 110018876
Orthostatic hypotension 223.84 18.32 23 511304 66226 110011746
Agranulocytosis 223.52 18.32 16 511311 61744 110016228
Full blood count abnormal 223.40 18.32 8 511319 56044 110021928
Drug ineffective for unapproved indication 222.85 18.32 98 511229 102740 109975232
Heart rate increased 222.55 18.32 202 511125 143632 109934340
Flushing 221.97 18.32 103 511224 104633 109973339
Wrong technique in product usage process 218.42 18.32 66 511261 87282 109990690
Blood pressure increased 216.87 18.32 552 510775 257821 109820151
Onychomadesis 215.37 18.32 578 510749 45085 110032887
Aggression 215.27 18.32 15 511312 59195 110018777
Blood urea increased 215.10 18.32 9 511318 54948 110023024
Immunodeficiency 214.71 18.32 522 510805 38316 110039656
Dyskinesia 213.61 18.32 5 511322 51441 110026531
Respiratory distress 213.00 18.32 32 511295 68842 110009130
Hepatic cytolysis 212.24 18.32 10 511317 55043 110022929
Plasma cell myeloma 209.70 18.32 23 511304 62913 110015059
Temperature regulation disorder 209.31 18.32 277 511050 12549 110065423
Cholestasis 208.94 18.32 26 511301 64492 110013480
Cerebral haemorrhage 208.41 18.32 27 511300 64941 110013031
Pyrexia 206.37 18.32 2919 508408 895346 109182626
Tubulointerstitial nephritis 205.64 18.32 11 511316 54273 110023699
Acute respiratory failure 204.98 18.32 48 511279 75212 110002760
Mucosal inflammation 204.60 18.32 94 511233 96047 109981925
Loss of consciousness 203.23 18.32 373 510954 195933 109882039
Respiratory arrest 202.90 18.32 18 511309 58281 110019691
Coronary artery disease 202.79 18.32 42 511285 71648 110006324
Hepatocellular injury 202.63 18.32 7 511320 50635 110027337
Contusion 202.22 18.32 1803 509524 231558 109846414
Eosinophilia 201.34 18.32 18 511309 57918 110020054
Pancreatitis acute 200.89 18.32 22 511305 60252 110017720
Multiple sclerosis relapse 200.83 18.32 7 511320 50233 110027739
Shock 199.50 18.32 12 511315 53576 110024396
Onychomycosis 199.42 18.32 505 510822 38026 110039946
Liver disorder 199.30 18.32 1232 510095 141011 109936961
Cardiogenic shock 198.76 18.32 18 511309 57320 110020652
Urticaria 198.29 18.32 2301 509026 316556 109761416
Altered state of consciousness 197.33 18.32 19 511308 57607 110020365
Device malfunction 195.10 18.32 391 510936 25167 110052805
Joint stiffness 194.85 18.32 719 510608 66524 110011448
Nail disorder 194.22 18.32 650 510677 57285 110020687
Pallor 192.35 18.32 19 511308 56448 110021524
Autoimmune disorder 191.28 18.32 702 510625 64781 110013191
Liver function test increased 190.89 18.32 864 510463 87684 109990288
Illness 187.89 18.32 816 510511 81355 109996617
Psychotic disorder 187.84 18.32 12 511315 50925 110027047
Weight decreased 187.32 18.32 1330 509997 466727 109611245
Generalised tonic-clonic seizure 187.31 18.32 18 511309 54662 110023310
Anxiety 186.49 18.32 890 510437 344188 109733784
Inappropriate schedule of product administration 185.20 18.32 417 510910 203220 109874752
Asthenia 185.10 18.32 2166 509161 686833 109391139
Upper gastrointestinal haemorrhage 184.15 18.32 12 511315 50084 110027888
Restlessness 183.84 18.32 22 511305 56237 110021735
X-ray abnormal 183.31 18.32 486 510841 37631 110040341
Lung disorder 182.50 18.32 1441 509886 178606 109899366
Swollen tongue 182.24 18.32 30 511297 60332 110017640
Hypophagia 181.14 18.32 17 511310 52609 110025363
Neurotoxicity 179.66 18.32 3 511324 42204 110035768
Stevens-Johnson syndrome 179.26 18.32 9 511318 46892 110031080
Deep vein thrombosis 179.15 18.32 230 511097 139657 109938315
Mental status changes 178.95 18.32 64 511263 76058 110001914
Hypervolaemia 178.46 18.32 13 511314 49447 110028525
Ventricular tachycardia 178.01 18.32 14 511313 49995 110027977
Blood lactate dehydrogenase increased 177.84 18.32 6 511321 44328 110033644
Deformity 177.60 18.32 227 511100 9933 110068039
Swelling face 177.53 18.32 103 511224 92218 109985754
Lymphocyte count decreased 176.10 18.32 27 511300 57216 110020756
Exostosis 174.38 18.32 538 510789 45418 110032554
Ejection fraction decreased 173.62 18.32 3 511324 40877 110037095
Hypothyroidism 173.58 18.32 60 511267 72839 110005133
Depressed mood 173.29 18.32 35 511292 60774 110017198
Gamma-glutamyltransferase increased 173.24 18.32 36 511291 61273 110016699
Prescribed underdose 172.46 18.32 677 510650 64497 110013475
Pulmonary hypertension 172.28 18.32 25 511302 55195 110022777
Pneumonitis 172.13 18.32 69 511258 76462 110001510
Colitis 171.45 18.32 133 511194 102190 109975782
Weight increased 170.97 18.32 2808 508519 416836 109661136
Circulatory collapse 168.40 18.32 7 511320 42986 110034986
Road traffic accident 167.64 18.32 957 510370 106441 109971531
Emotional distress 167.08 18.32 10 511317 44837 110033135
Septic shock 166.91 18.32 295 511032 157233 109920739
Chronic obstructive pulmonary disease 166.84 18.32 155 511172 109003 109968969
Adjustment disorder with depressed mood 166.76 18.32 514 510813 43369 110034603
Dizziness 166.54 18.32 2251 509076 695942 109382030
Acute respiratory distress syndrome 166.17 18.32 24 511303 53174 110024798
Coagulopathy 166.03 18.32 5 511322 40906 110037066
Feeling abnormal 166.00 18.32 368 510959 180343 109897629
Abnormal behaviour 165.24 18.32 3 511324 39036 110038936
Accidental overdose 165.17 18.32 22 511305 51812 110026160
Blepharospasm 163.56 18.32 592 510735 54259 110023713
Tachypnoea 162.91 18.32 4 511323 39391 110038581
Pneumonia 161.28 18.32 2969 508358 873745 109204227
Apparent death 160.74 18.32 122 511205 2780 110075192
Live birth 160.38 18.32 692 510635 68792 110009180
Therapy non-responder 159.96 18.32 1260 510067 156047 109921925
Condition aggravated 159.94 18.32 4488 506839 730348 109347624
Bone marrow failure 159.32 18.32 36 511291 57812 110020160
Obstructive airways disorder 158.59 18.32 15 511312 46134 110031838
Intentional self-injury 157.92 18.32 3 511324 37426 110040546
Arrhythmia 157.68 18.32 62 511265 69513 110008459
Leukocytosis 157.59 18.32 29 511298 53799 110024173
Joint destruction 156.92 18.32 222 511105 10721 110067251
Rheumatoid factor negative 156.88 18.32 89 511238 1211 110076761
Vertigo 155.87 18.32 105 511222 86765 109991207
Food allergy 155.66 18.32 308 511019 19640 110058332
Chronic kidney disease 155.61 18.32 79 511248 76212 110001760
Eczema 153.33 18.32 71 511256 72222 110005750
Nightmare 153.32 18.32 6 511321 38857 110039115
Disseminated intravascular coagulation 151.43 18.32 10 511317 41276 110036696
Speech disorder 151.28 18.32 48 511279 61521 110016451
Bone pain 151.01 18.32 56 511271 65077 110012895
Product dose omission issue 150.30 18.32 872 510455 320910 109757062
Drug withdrawal syndrome 149.71 18.32 6 511321 38048 110039924
Product prescribing error 149.54 18.32 28 511299 51303 110026669
Sinus tachycardia 148.89 18.32 16 511311 44477 110033495
Finger deformity 148.19 18.32 411 510916 32681 110045291
Elbow deformity 147.08 18.32 90 511237 1420 110076552
Hemiparesis 146.38 18.32 16 511311 43887 110034085
Diabetic ketoacidosis 146.33 18.32 13 511314 42045 110035927
Irritability 146.04 18.32 23 511304 47786 110030186
Anti-cyclic citrullinated peptide antibody 145.95 18.32 300 511027 19664 110058308
Urinary incontinence 144.80 18.32 25 511302 48562 110029410
Blood calcium decreased 143.26 18.32 5 511322 35840 110042132
Therapeutic response decreased 142.89 18.32 848 510479 95651 109982321
Myocardial infarction 142.84 18.32 435 510892 191648 109886324
Clostridium difficile colitis 140.89 18.32 18 511309 43760 110034212
Dry mouth 139.80 18.32 1477 509850 198471 109879501
Presyncope 139.60 18.32 28 511299 48859 110029113
Acute hepatic failure 139.37 18.32 7 511320 36461 110041511
Electrolyte imbalance 138.72 18.32 8 511319 37020 110040952
Retinitis 138.39 18.32 395 510932 31932 110046040
Inappropriate antidiuretic hormone secretion 137.87 18.32 4 511323 33847 110044125
Myoclonus 137.81 18.32 3 511324 32995 110044977
Lymphopenia 135.57 18.32 14 511313 40156 110037816
Osteonecrosis of jaw 134.02 18.32 29 511298 47988 110029984
Pericardial effusion 132.97 18.32 49 511278 57168 110020804
Skin necrosis 132.92 18.32 302 511025 21210 110056762
Rash maculo-papular 132.78 18.32 90 511237 74132 110003840
Oedema peripheral 132.32 18.32 932 510395 327728 109750244
Basal cell carcinoma 131.94 18.32 485 510842 44785 110033187
Skin ulcer 131.23 18.32 613 510714 63032 110014940
Injection site erythema 131.08 18.32 145 511182 94031 109983941
Subdural haematoma 130.33 18.32 10 511317 36444 110041528
C-reactive protein 130.22 18.32 371 510956 29960 110048012
Rheumatoid lung 130.16 18.32 128 511199 4176 110073796
Dysuria 129.54 18.32 58 511269 60173 110017799
Intentional product misuse 129.28 18.32 262 511065 132642 109945330
Joint laxity 129.25 18.32 101 511226 2406 110075566
Adverse drug reaction 128.73 18.32 883 510444 104676 109973296
Hyperbilirubinaemia 127.26 18.32 3 511324 30668 110047304
Lip swelling 127.19 18.32 38 511289 50629 110027343
Fine motor skill dysfunction 127.13 18.32 151 511176 6123 110071849
Arthrodesis 126.25 18.32 103 511224 2615 110075357
Diplopia 126.08 18.32 21 511306 41873 110036099
Bacteraemia 125.91 18.32 22 511305 42368 110035604
Lupus vulgaris 125.16 18.32 393 510934 33490 110044482
Blood sodium decreased 125.16 18.32 15 511312 38304 110039668
Device dislocation 124.72 18.32 5 511322 31699 110046273
Seronegative arthritis 124.71 18.32 221 511106 12956 110065016
Blood potassium decreased 124.66 18.32 47 511280 54067 110023905
SLE arthritis 123.80 18.32 60 511267 577 110077395
Musculoskeletal disorder 123.55 18.32 303 511024 22361 110055611
Human antichimeric antibody positive 121.01 18.32 84 511243 1658 110076314
Oral mucosal exfoliation 121.00 18.32 82 511245 1554 110076418
Device related infection 120.74 18.32 19 511308 39500 110038472
Poisoning 120.18 18.32 3 511324 29102 110048870
Musculoskeletal deformity 120.04 18.32 80 511247 1473 110076499
Staphylococcal infection 119.62 18.32 89 511238 69855 110008117
Haemorrhage intracranial 119.56 18.32 3 511324 28966 110049006
Nasal congestion 119.33 18.32 168 511159 98114 109979858
Renal tubular necrosis 119.23 18.32 5 511322 30470 110047502
Ear pain 118.95 18.32 525 510802 52701 110025271
Pollakiuria 118.75 18.32 29 511298 44166 110033806
Product storage error 117.93 18.32 290 511037 21438 110056534
Decreased appetite 117.74 18.32 1522 509805 474324 109603648
Ataxia 117.59 18.32 5 511322 30103 110047869
Premature delivery 116.68 18.32 6 511321 30626 110047346
Limb deformity 116.26 18.32 113 511214 3633 110074339
Angina pectoris 116.26 18.32 72 511255 62223 110015749
Polyarthritis 115.81 18.32 265 511062 18698 110059274
Tinnitus 115.74 18.32 68 511259 60472 110017500
Drug resistance 115.54 18.32 58 511269 56316 110021656
Transient ischaemic attack 115.24 18.32 77 511250 63905 110014067
Acute myeloid leukaemia 114.91 18.32 19 511308 38091 110039881
Cholelithiasis 114.67 18.32 76 511251 63346 110014626
Metastases to bone 113.89 18.32 8 511319 31364 110046608
Cytomegalovirus infection 113.11 18.32 55 511272 54389 110023583
Cerebral infarction 111.35 18.32 50 511277 51788 110026184
Back injury 110.87 18.32 474 510853 46925 110031047
Diverticulitis 110.71 18.32 516 510811 53006 110024966
Face oedema 109.57 18.32 13 511314 33456 110044516
Toxic skin eruption 109.40 18.32 4 511323 27511 110050461
Hypoalbuminaemia 109.35 18.32 6 511321 28968 110049004
Abdominal pain lower 109.33 18.32 20 511307 37263 110040709
Extrapyramidal disorder 108.87 18.32 6 511321 28861 110049111
Full blood count decreased 108.81 18.32 11 511316 32088 110045884
Sinus bradycardia 108.55 18.32 7 511320 29476 110048496
Disease recurrence 108.34 18.32 74 511253 60710 110017262
Chromaturia 108.01 18.32 7 511320 29353 110048619
Flatulence 107.86 18.32 53 511274 52096 110025876
Body height below normal 107.53 18.32 84 511243 2000 110075972
Cellulitis 107.40 18.32 267 511060 125749 109952223
Intestinal obstruction 107.24 18.32 56 511271 53171 110024801
Small intestinal obstruction 106.74 18.32 12 511315 32201 110045771
Productive cough 106.41 18.32 231 511096 114074 109963898
Posterior reversible encephalopathy syndrome 106.40 18.32 15 511312 33846 110044126
Nephropathy toxic 105.89 18.32 5 511322 27473 110050499
Hyperlipidaemia 105.62 18.32 19 511308 35829 110042143
Paraesthesia oral 105.61 18.32 15 511312 33656 110044316
Ileus 105.56 18.32 10 511317 30719 110047253
Muscle twitching 104.83 18.32 9 511318 29926 110048046
Dysphonia 104.47 18.32 118 511209 75811 110002161
Joint dislocation 103.62 18.32 371 510956 33819 110044153
Rectal haemorrhage 102.83 18.32 253 511074 119580 109958392
Rhinorrhoea 102.76 18.32 199 511128 102467 109975505
Leukopenia 102.22 18.32 349 510978 148442 109929530
Hyperthyroidism 101.92 18.32 9 511318 29252 110048720
Mitral valve incompetence 101.88 18.32 16 511311 33313 110044659
Hyperhidrosis 101.72 18.32 482 510845 186816 109891156
Accidental exposure to product 101.66 18.32 52 511275 49956 110028016
Troponin increased 101.42 18.32 10 511317 29756 110048216
Hypoaesthesia 100.89 18.32 2026 509301 312197 109765775
Glomerular filtration rate decreased 100.60 18.32 9 511318 28947 110049025
Clostridium difficile infection 100.44 18.32 58 511269 52071 110025901
Infusion site reaction 100.24 18.32 240 511087 17442 110060530
Red blood cell sedimentation rate 99.94 18.32 122 511205 5092 110072880
Hypersomnia 99.47 18.32 8 511319 28053 110049919
Glaucoma 99.18 18.32 278 511049 22239 110055733
Gastritis 98.92 18.32 63 511264 53636 110024336
Cyanosis 98.74 18.32 11 511316 29730 110048242
Lupus-like syndrome 98.57 18.32 412 510915 40380 110037592
Cardiac failure acute 97.50 18.32 3 511324 24075 110053897
Joint arthroplasty 97.43 18.32 100 511227 3437 110074535
Subarachnoid haemorrhage 96.10 18.32 12 511315 29690 110048282
Nervousness 95.53 18.32 26 511301 36825 110041147
Haematoma 95.45 18.32 78 511249 58398 110019574
Chest pain 94.85 18.32 1199 510128 375176 109702796
Blood pressure fluctuation 94.78 18.32 124 511203 74700 110003272
Myelodysplastic syndrome 94.29 18.32 28 511299 37456 110040516
Hypertension 93.96 18.32 3053 508274 507031 109570941
Transfusion 93.92 18.32 6 511321 25466 110052506
Arteriosclerosis 93.87 18.32 5 511322 24762 110053210
Malnutrition 93.38 18.32 9 511318 27270 110050702
Visual acuity reduced 92.76 18.32 18 511309 32155 110045817
Hypothermia 91.85 18.32 8 511319 26294 110051678
Adverse reaction 91.29 18.32 323 511004 29271 110048701
Tuberculin test positive 90.87 18.32 98 511229 3570 110074402
Blood triglycerides increased 90.15 18.32 5 511322 23921 110054051
Ischaemic stroke 89.89 18.32 39 511288 41224 110036748
Metastases to liver 89.81 18.32 26 511301 35360 110042612
Dystonia 89.71 18.32 8 511319 25797 110052175
Arteriosclerosis coronary artery 89.49 18.32 7 511320 25111 110052861
Pain in extremity 89.31 18.32 2914 508413 484204 109593768
Parkinsonism 89.00 18.32 3 511324 22184 110055788
Left ventricular dysfunction 88.24 18.32 5 511322 23488 110054484
Alanine aminotransferase increased 87.91 18.32 494 510833 183279 109894693
Alanine aminotransferase abnormal 87.63 18.32 156 511171 9178 110068794
Paranoia 86.45 18.32 4 511323 22370 110055602
Abdominal pain upper 86.29 18.32 2169 509158 346942 109731030
Aspiration 86.12 18.32 18 511309 30515 110047457
Osteonecrosis 85.25 18.32 25 511302 33716 110044256
Laryngitis 84.88 18.32 405 510922 42006 110035966
Bone swelling 84.57 18.32 69 511258 1752 110076220
Mental impairment 84.48 18.32 5 511322 22634 110055338
Skin discolouration 84.40 18.32 62 511265 48984 110028988
Eye swelling 84.39 18.32 24 511303 33024 110044948
Surgical failure 84.21 18.32 53 511274 881 110077091
Head injury 84.12 18.32 47 511280 42970 110035002
Mental disorder 83.97 18.32 37 511290 38754 110039218
Injection site reaction 83.77 18.32 701 510626 88369 109989603
Thrombosis 83.70 18.32 242 511085 108420 109969552
Pregnancy 83.61 18.32 461 510866 50606 110027366
Myocardial ischaemia 83.43 18.32 12 511315 26672 110051300
Haemolytic anaemia 83.32 18.32 3 511324 20917 110057055
Right ventricular failure 82.73 18.32 11 511316 25943 110052029
Feeling cold 82.61 18.32 27 511300 33960 110044012
Pulmonary arterial hypertension 82.52 18.32 24 511303 32544 110045428
Enthesopathy 82.51 18.32 180 511147 12298 110065674
Haemophagocytic lymphohistiocytosis 82.31 18.32 22 511305 31537 110046435
Throat irritation 81.87 18.32 76 511251 53476 110024496
Splenomegaly 81.49 18.32 9 511318 24489 110053483
Gastric disorder 81.46 18.32 338 510989 33019 110044953
Physical disability 81.36 18.32 109 511218 4997 110072975
Therapeutic response unexpected 81.27 18.32 8 511319 23835 110054137
Myopathy 80.96 18.32 10 511317 24950 110053022
Schizophrenia 80.90 18.32 5 511322 21821 110056151
Cytopenia 80.45 18.32 20 511307 30096 110047876
Psychomotor hyperactivity 80.44 18.32 3 511324 20274 110057698
Thirst 80.38 18.32 5 511322 21702 110056270
Neutrophil count increased 79.98 18.32 30 511297 34622 110043350
Blood glucose decreased 79.91 18.32 19 511308 29469 110048503
Panic attack 79.71 18.32 18 511309 28922 110049050
Cardiac murmur 79.56 18.32 10 511317 24618 110053354
Hemiplegia 79.37 18.32 7 511320 22775 110055197
Product use in unapproved indication 78.93 18.32 1525 509802 445852 109632120
Atlantoaxial instability 78.82 18.32 35 511292 270 110077702
Maternal exposure timing unspecified 78.79 18.32 245 511082 20768 110057204
Anal incontinence 78.59 18.32 6 511321 21958 110056014
Transaminases increased 78.31 18.32 107 511220 63283 110014689
Proteinuria 77.85 18.32 44 511283 39974 110037998
Eosinophil count increased 77.53 18.32 5 511322 21053 110056919
Peritonitis 77.34 18.32 27 511300 32580 110045392
Hypovolaemia 77.33 18.32 6 511321 21668 110056304
Drug tolerance 77.25 18.32 209 511118 16376 110061596
Loose body in joint 77.11 18.32 59 511268 1361 110076611
Neck pain 77.06 18.32 890 510437 122240 109955732
Transplant rejection 76.92 18.32 11 511316 24556 110053416
Product administration error 76.70 18.32 38 511289 37179 110040793
Sleep apnoea syndrome 76.52 18.32 46 511281 40401 110037571
Atrioventricular block complete 76.28 18.32 4 511323 20078 110057894
Sudden death 76.20 18.32 11 511316 24384 110053588
Purpura 76.17 18.32 11 511316 24377 110053595
Ventricular extrasystoles 76.12 18.32 8 511319 22633 110055339
Upper respiratory tract infection 75.93 18.32 935 510392 130393 109947579
Intestinal sepsis 75.87 18.32 51 511276 953 110077019
Atrial flutter 75.65 18.32 11 511316 24251 110053721
Hyperthermia 75.58 18.32 6 511321 21266 110056706
Blindness 75.12 18.32 37 511290 36322 110041650
Shock haemorrhagic 74.94 18.32 17 511310 27230 110050742
Spinal instability 74.93 18.32 39 511288 442 110077530
Oesophagitis 74.92 18.32 20 511307 28695 110049277
Eye pruritus 74.60 18.32 29 511298 32746 110045226
Metastases to central nervous system 74.35 18.32 9 511318 22808 110055164
Cardiomyopathy 74.13 18.32 31 511296 33494 110044478
Blood iron abnormal 74.11 18.32 59 511268 1445 110076527
Tricuspid valve incompetence 74.02 18.32 11 511316 23862 110054110
Bronchospasm 73.53 18.32 24 511303 30215 110047757
Respiratory disorder 73.20 18.32 573 510754 70809 110007163
Blood magnesium decreased 72.88 18.32 5 511322 19991 110057981
Impaired quality of life 72.68 18.32 24 511303 29993 110047979
Rash papular 72.59 18.32 19 511308 27620 110050352
Haematocrit decreased 72.59 18.32 121 511206 65996 110011976
Faeces discoloured 72.52 18.32 33 511294 33915 110044057
Crying 72.50 18.32 15 511312 25613 110052359
Abdominal distension 72.16 18.32 493 510834 174610 109903362
Heart rate irregular 72.15 18.32 34 511293 34240 110043732
Erythema multiforme 72.11 18.32 7 511320 21090 110056882
Bacterial infection 71.97 18.32 64 511263 45972 110032000
Herpes zoster 71.26 18.32 791 510536 107588 109970384
Thrombotic microangiopathy 71.12 18.32 23 511304 29126 110048846
Sensory loss 71.08 18.32 8 511319 21449 110056523
Blood albumin decreased 70.76 18.32 20 511307 27632 110050340
Atelectasis 70.51 18.32 41 511286 36671 110041301
Dermatitis atopic 70.12 18.32 16 511311 25525 110052447
Nodule 70.00 18.32 318 511009 32313 110045659
Heart rate decreased 70.00 18.32 176 511151 82580 109995392
Oliguria 69.99 18.32 4 511323 18653 110059319
Drug level decreased 69.51 18.32 4 511323 18544 110059428
Thyroid neoplasm 69.46 18.32 81 511246 3220 110074752
Skin haemorrhage 69.28 18.32 15 511312 24812 110053160
Enterococcal infection 68.98 18.32 7 511320 20359 110057613
Pathogen resistance 68.80 18.32 3 511324 17669 110060303
Mineral metabolism disorder 68.79 18.32 35 511292 377 110077595
Eye pain 68.76 18.32 78 511249 50021 110027951
Acute coronary syndrome 68.63 18.32 12 511315 23100 110054872
Ageusia 68.54 18.32 6 511321 19639 110058333
Pulmonary alveolar haemorrhage 68.06 18.32 7 511320 20143 110057829
Impaired work ability 67.92 18.32 272 511055 26147 110051825
Device defective 67.76 18.32 86 511241 3736 110074236
Bronchitis chronic 67.58 18.32 98 511229 4842 110073130
Electrocardiogram abnormal 67.26 18.32 5 511322 18704 110059268
Lymphadenopathy 67.18 18.32 120 511207 63715 110014257
Bronchopulmonary aspergillosis 67.03 18.32 27 511300 29836 110048136
Pneumothorax 66.93 18.32 40 511287 35245 110042727
Rales 66.92 18.32 16 511311 24723 110053249
Insurance issue 66.70 18.32 150 511177 10462 110067510
Wrist deformity 66.68 18.32 78 511249 3111 110074861
Hypernatraemia 66.36 18.32 4 511323 17829 110060143
Pseudomonas infection 66.17 18.32 23 511304 27830 110050142
Pemphigoid 66.16 18.32 7 511320 19700 110058272
Multiple fractures 66.12 18.32 135 511192 8805 110069167
Myocarditis 66.12 18.32 28 511299 30027 110047945
Hot flush 66.08 18.32 128 511199 65908 110012064
Neuralgia 65.97 18.32 76 511251 48402 110029570
Polyuria 65.94 18.32 4 511323 17734 110060238
Presbyacusis 65.81 18.32 73 511254 2746 110075226
Terminal state 65.58 18.32 104 511223 5563 110072409
Poor quality sleep 65.32 18.32 24 511303 28053 110049919
Wheelchair user 64.74 18.32 124 511203 7718 110070254
Chronic sinusitis 64.45 18.32 18 511309 25066 110052906
Glycosylated haemoglobin increased 64.44 18.32 15 511312 23604 110054368
Peripheral sensory neuropathy 64.39 18.32 3 511324 16677 110061295
Therapeutic response shortened 64.38 18.32 28 511299 29555 110048417
Urine output decreased 64.38 18.32 8 511319 19868 110058104
Blood calcium increased 64.35 18.32 5 511322 18035 110059937
Metastases to lung 64.22 18.32 14 511313 23049 110054923
Incontinence 64.19 18.32 3 511324 16632 110061340
Vascular device infection 63.64 18.32 3 511324 16509 110061463
Joint effusion 63.48 18.32 227 511100 20678 110057294
Ear infection 63.46 18.32 502 510825 62230 110015742
Muscle spasticity 63.40 18.32 331 510996 35584 110042388
Dialysis 63.29 18.32 8 511319 19611 110058361
Concomitant disease aggravated 62.98 18.32 3 511324 16361 110061611
Hepatic cirrhosis 62.94 18.32 531 510796 67095 110010877
Sinus congestion 62.92 18.32 31 511296 30428 110047544
Duodenal ulcer 62.85 18.32 8 511319 19506 110058466
Nocturia 62.65 18.32 4 511323 16986 110060986
Pain of skin 62.63 18.32 9 511318 20020 110057952
Aspartate aminotransferase increased 62.62 18.32 457 510870 159479 109918493
Sneezing 62.46 18.32 35 511292 31949 110046023
Myasthenia gravis 62.09 18.32 12 511315 21499 110056473
Gout 61.92 18.32 47 511280 36519 110041453
Supraventricular tachycardia 61.87 18.32 18 511309 24404 110053568
Appendicitis 61.85 18.32 27 511300 28437 110049535
Blood loss anaemia 61.56 18.32 6 511321 18019 110059953
Hepatitis 61.39 18.32 662 510665 89392 109988580
Enteritis 61.34 18.32 8 511319 19148 110058824
Mania 61.31 18.32 11 511316 20785 110057187
Cardiomegaly 61.16 18.32 29 511298 29101 110048871
Taste disorder 61.16 18.32 514 510813 64873 110013099
Therapy partial responder 61.03 18.32 49 511278 37012 110040960
Renal disorder 60.63 18.32 84 511243 49395 110028577
Walking aid user 60.38 18.32 253 511074 24822 110053150
Hypocalcaemia 60.09 18.32 133 511194 65233 110012739
Injection site swelling 59.91 18.32 122 511205 61668 110016304
Hepatomegaly 59.63 18.32 13 511314 21401 110056571
Dermatitis bullous 59.43 18.32 6 511321 17523 110060449
Anticipatory anxiety 59.19 18.32 48 511279 1208 110076764
Bone cyst 59.08 18.32 78 511249 3525 110074447
Vaginal haemorrhage 59.06 18.32 21 511306 25053 110052919
COVID-19 pneumonia 58.83 18.32 51 511276 37092 110040880
Peripheral coldness 58.76 18.32 8 511319 18532 110059440
Tongue disorder 58.58 18.32 172 511155 14126 110063846
Foot operation 58.37 18.32 114 511213 7199 110070773
Rash macular 57.85 18.32 56 511271 38630 110039342
Osteoporotic fracture 57.74 18.32 95 511232 5242 110072730
Micturition urgency 57.44 18.32 10 511317 19310 110058662
Lung infiltration 57.38 18.32 21 511306 24607 110053365
Hypotonia 57.20 18.32 4 511323 15741 110062231
Hypoaesthesia oral 57.18 18.32 6 511321 16996 110060976
Ankle operation 57.09 18.32 49 511278 1337 110076635
Haemolysis 56.74 18.32 4 511323 15635 110062337
Rebound effect 56.08 18.32 3 511324 14803 110063169
Klebsiella infection 56.01 18.32 12 511315 19997 110057975
Exposure during pregnancy 55.86 18.32 1086 510241 166338 109911634
Petechiae 55.84 18.32 19 511308 23298 110054674
Polyneuropathy 55.69 18.32 40 511287 31972 110046000
Bone density decreased 55.55 18.32 182 511145 15860 110062112
Benign prostatic hyperplasia 55.18 18.32 9 511318 18225 110059747
Gastric haemorrhage 55.15 18.32 5 511322 15910 110062062
Systemic lupus erythematosus rash 55.09 18.32 57 511270 1978 110075994
Mesenteritis 54.57 18.32 29 511298 344 110077628
Cold sweat 54.43 18.32 17 511310 22014 110055958
Product label confusion 53.98 18.32 228 511099 22449 110055523
Vaginal discharge 53.83 18.32 9 511318 17899 110060073
Respiratory symptom 53.71 18.32 4 511323 14941 110063031
Oropharyngeal pain 53.70 18.32 385 510942 134891 109943081
Cardiac disorder 53.69 18.32 177 511150 76103 110001869
Abortion spontaneous 53.18 18.32 48 511279 34234 110043738
Eating disorder 53.10 18.32 39 511288 30819 110047153
Limb discomfort 52.94 18.32 347 510980 40507 110037465
Urinary tract infection 52.80 18.32 1128 510199 325154 109752818
Skin neoplasm excision 52.77 18.32 56 511271 2002 110075970
Hyperaesthesia 52.76 18.32 4 511323 14723 110063249
Ankle arthroplasty 52.68 18.32 62 511265 2489 110075483
Off label use 52.62 18.32 6105 505222 1494080 108583892
Fatigue 52.48 18.32 6403 504924 1209555 108868417
Dizziness postural 52.25 18.32 4 511323 14605 110063367
Progressive multifocal leukoencephalopathy 52.16 18.32 25 511302 24931 110053041
Product temperature excursion issue 52.11 18.32 38 511289 813 110077159
Venoocclusive liver disease 52.10 18.32 5 511322 15202 110062770
Hyperuricaemia 51.91 18.32 4 511323 14527 110063445
Skin fissures 51.89 18.32 24 511303 24434 110053538
Atrioventricular block 51.82 18.32 8 511319 16869 110061103
Thinking abnormal 51.81 18.32 5 511322 15135 110062837
Pulseless electrical activity 51.32 18.32 8 511319 16749 110061223
Chondropathy 51.25 18.32 65 511262 2822 110075150
Diabetes mellitus inadequate control 50.76 18.32 38 511289 29737 110048235
Ulcer 50.39 18.32 357 510970 42759 110035213
Anaphylactic shock 49.78 18.32 102 511225 51444 110026528
Sensory disturbance 49.72 18.32 10 511317 17419 110060553
Loss of employment 49.67 18.32 69 511258 3275 110074697
Coronary artery occlusion 49.52 18.32 7 511320 15765 110062207
Device occlusion 49.46 18.32 6 511321 15179 110062793
Intestinal ischaemia 48.93 18.32 8 511319 16171 110061801
Sebaceous gland infection 48.90 18.32 21 511306 148 110077824
Respiratory acidosis 48.84 18.32 4 511323 13822 110064150
Porphyria acute 48.80 18.32 194 511133 18586 110059386
Haemorrhagic stroke 48.68 18.32 4 511323 13785 110064187
Aspergillus infection 48.64 18.32 29 511298 25587 110052385
Increased appetite 48.58 18.32 6 511321 14971 110063001
Post procedural haemorrhage 48.44 18.32 7 511320 15505 110062467
Acute pulmonary oedema 47.97 18.32 10 511317 16986 110060986
Dysstasia 47.89 18.32 49 511278 32937 110045035
Injection site warmth 47.59 18.32 11 511316 17394 110060578
Fistula 47.55 18.32 7 511320 15292 110062680
Stress cardiomyopathy 47.39 18.32 8 511319 15798 110062174
Graft versus host disease 47.39 18.32 14 511313 18792 110059180
Lacrimation increased 47.22 18.32 44 511283 30906 110047066
Dementia 47.19 18.32 46 511281 31627 110046345
Mood altered 46.88 18.32 20 511307 21355 110056617
Respiratory rate increased 46.79 18.32 29 511298 25054 110052918
Joint injury 46.65 18.32 331 510996 39663 110038309
Escherichia infection 46.59 18.32 26 511301 23790 110054182
Neurological symptom 46.57 18.32 8 511319 15600 110062372
Colitis microscopic 46.42 18.32 152 511175 13242 110064730
COVID-19 46.39 18.32 825 510502 244235 109833737
Multiple-drug resistance 46.29 18.32 4 511323 13231 110064741
Unevaluable event 46.27 18.32 131 511196 59096 110018876
Proctalgia 46.23 18.32 4 511323 13218 110064754
Iron deficiency 46.11 18.32 14 511313 18462 110059510
Drug specific antibody 46.03 18.32 61 511266 2767 110075205
Rhinitis allergic 45.79 18.32 13 511314 17909 110060063
Osteosclerosis 45.69 18.32 78 511249 4437 110073535
Red blood cell count decreased 45.69 18.32 154 511173 65769 110012203
Systemic inflammatory response syndrome 45.46 18.32 4 511323 13039 110064933
Upper-airway cough syndrome 45.44 18.32 9 511318 15848 110062124
Congestive cardiomyopathy 45.38 18.32 6 511321 14213 110063759
Psoriasis 45.33 18.32 904 510423 139089 109938883
Haemorrhoids 45.29 18.32 59 511268 35613 110042359
Failure to thrive 45.12 18.32 5 511322 13569 110064403
Bone disorder 45.07 18.32 206 511121 20986 110056986
Apathy 44.93 18.32 10 511317 16229 110061743
White blood cell count increased 44.85 18.32 263 511064 96579 109981393
Head discomfort 44.61 18.32 16 511311 18984 110058988
Hypovolaemic shock 44.57 18.32 7 511320 14576 110063396
Motor dysfunction 44.45 18.32 29 511298 24377 110053595
Pleural fibrosis 44.36 18.32 75 511252 4233 110073739
No adverse event 44.31 18.32 183 511144 73656 110004316
Hydronephrosis 44.28 18.32 20 511307 20645 110057327
Metastases to lymph nodes 44.21 18.32 8 511319 15024 110062948
Cholecystitis 44.17 18.32 33 511294 25849 110052123
Eyelid ptosis 44.07 18.32 5 511322 13322 110064650
Exercise tolerance decreased 44.03 18.32 3 511324 12064 110065908
Staphylococcal sepsis 43.97 18.32 13 511314 17441 110060531
Nervous system disorder 43.96 18.32 49 511278 31672 110046300
Red cell distribution width decreased 43.87 18.32 53 511274 2188 110075784
Eye irritation 43.86 18.32 54 511273 33398 110044574
Oral candidiasis 43.71 18.32 88 511239 44672 110033300
Multiple sclerosis 43.55 18.32 33 511294 25665 110052307
Sputum discoloured 43.50 18.32 39 511288 27906 110050066
Cholangitis 43.34 18.32 11 511316 16324 110061648
Stress 43.20 18.32 297 511030 105051 109972921
Cholecystitis acute 43.10 18.32 10 511317 15772 110062200
Blood test abnormal 43.09 18.32 41 511286 28513 110049459
Aortic stenosis 42.93 18.32 5 511322 13054 110064918
Staphylococcal bacteraemia 42.83 18.32 12 511315 16676 110061296
Spinal stenosis 42.60 18.32 188 511139 18868 110059104
Radiculopathy 42.56 18.32 18 511309 19318 110058654
Hepatitis B virus test positive 42.46 18.32 28 511299 506 110077466
Facial paralysis 42.46 18.32 30 511297 24184 110053788
Paralysis 42.37 18.32 10 511317 15590 110062382
Drug level below therapeutic 42.31 18.32 3 511324 11670 110066302
Wrist surgery 42.22 18.32 34 511293 847 110077125
Hiccups 42.12 18.32 5 511322 12864 110065108
Diverticulum 42.08 18.32 10 511317 15516 110062456
Procedural pain 41.98 18.32 62 511265 35503 110042469
Temperature intolerance 41.96 18.32 7 511320 13943 110064029
Vascular access complication 41.87 18.32 55 511272 2473 110075499
Abnormal dreams 41.75 18.32 5 511322 12775 110065197
Wheezing 41.70 18.32 1507 509820 253723 109824249
Pleural thickening 41.59 18.32 64 511263 3335 110074637
Product quality issue 41.54 18.32 543 510784 76756 110001216
Granulocytopenia 41.47 18.32 5 511322 12710 110065262
Cerebral ischaemia 41.41 18.32 4 511323 12100 110065872
Skin plaque 41.17 18.32 5 511322 12640 110065332
Hypokinesia 41.04 18.32 25 511302 21801 110056171
Parosmia 41.03 18.32 6 511321 13174 110064798
Gastrointestinal procedural complication 40.96 18.32 26 511301 439 110077533
Infusion site erythema 40.79 18.32 4 511323 11955 110066017
Intestinal perforation 40.78 18.32 23 511304 20921 110057051
Femur fracture 40.76 18.32 348 510979 44121 110033851
Hypertensive crisis 40.41 18.32 32 511295 24340 110053632
Abdominal tenderness 40.38 18.32 5 511322 12452 110065520
Bunion operation 40.22 18.32 34 511293 908 110077064
Demyelination 40.15 18.32 115 511212 9314 110068658
Hypoacusis 39.94 18.32 63 511264 35128 110042844
Bundle branch block left 39.82 18.32 6 511321 12882 110065090
Nail operation 39.77 18.32 44 511283 1650 110076322
Faecaloma 39.63 18.32 10 511317 14898 110063074
Dermatitis allergic 39.59 18.32 202 511125 21522 110056450
Lower gastrointestinal haemorrhage 39.44 18.32 18 511309 18468 110059504
Cardiac failure chronic 39.24 18.32 8 511319 13803 110064169
Muscle atrophy 39.10 18.32 7 511320 13247 110064725
Large intestine perforation 39.05 18.32 14 511313 16615 110061357
Blood creatine increased 38.92 18.32 4 511323 11517 110066455
Clostridium test positive 38.91 18.32 3 511324 10890 110067082
Perineal rash 38.87 18.32 15 511312 77 110077895
Protein urine present 38.76 18.32 4 511323 11480 110066492
Injection site mass 38.73 18.32 34 511293 24579 110053393
Infusion site pain 38.69 18.32 16 511311 17403 110060569
Hepatitis C 38.51 18.32 6 511321 12567 110065405
Normochromic normocytic anaemia 38.29 18.32 7 511320 13050 110064922
Enterocolitis 38.07 18.32 20 511307 18929 110059043
Heavy menstrual bleeding 38.05 18.32 14 511313 16351 110061621
Immune thrombocytopenia 37.97 18.32 29 511298 22465 110055507
Foetal death 37.94 18.32 161 511166 15884 110062088
Migraine 37.89 18.32 1051 510276 170601 109907371
Brain injury 37.89 18.32 8 511319 13468 110064504
Nephropathy 37.85 18.32 8 511319 13459 110064513
Spinal column injury 37.51 18.32 50 511277 2281 110075691
Hypercapnia 37.37 18.32 4 511323 11155 110066817
Autoimmune hepatitis 37.34 18.32 11 511316 14793 110063179
Eyelid oedema 37.31 18.32 12 511315 15250 110062722
Caesarean section 37.25 18.32 9 511318 13808 110064164
Ankle deformity 37.25 18.32 29 511298 687 110077285
Metabolic disorder 37.24 18.32 3 511324 10507 110067465
Metabolic encephalopathy 36.95 18.32 4 511323 11056 110066916
Post transplant lymphoproliferative disorder 36.91 18.32 13 511314 15600 110062372
Ocular hyperaemia 36.88 18.32 79 511248 39207 110038765
Bacterial sepsis 36.88 18.32 3 511324 10423 110067549
Nasal polyps 36.78 18.32 8 511319 13192 110064780
Initial insomnia 36.72 18.32 3 511324 10386 110067586
Angina unstable 36.64 18.32 15 511312 16417 110061555
Fungal infection 36.37 18.32 117 511210 50689 110027283
Synovial cyst 36.33 18.32 126 511201 11304 110066668
Protein total decreased 36.22 18.32 4 511323 10886 110067086
Prostatic specific antigen increased 36.07 18.32 7 511320 12504 110065468
Mean platelet volume decreased 36.05 18.32 59 511268 3241 110074731
Lumbosacral plexopathy 36.01 18.32 15 511312 97 110077875
Immune-mediated enterocolitis 35.83 18.32 3 511324 10182 110067790
Ovarian neoplasm 35.81 18.32 27 511300 609 110077363
Breast cancer stage II 35.77 18.32 233 511094 27142 110050830
Infiltration anaesthesia 35.67 18.32 17 511310 157 110077815
Blood glucose abnormal 35.64 18.32 8 511319 12908 110065064
Endocarditis 35.48 18.32 9 511318 13362 110064610
Pneumonia fungal 35.37 18.32 12 511315 14742 110063230
Fear 35.35 18.32 33 511294 23160 110054812
Low density lipoprotein increased 35.27 18.32 4 511323 10662 110067310
Throat tightness 35.20 18.32 63 511264 33426 110044546
Coronary artery stenosis 35.11 18.32 10 511317 13748 110064224
Left ventricular hypertrophy 34.98 18.32 9 511318 13235 110064737
Body temperature decreased 34.90 18.32 74 511253 36861 110041111
Drug effective for unapproved indication 34.88 18.32 11 511316 14156 110063816
Cystitis haemorrhagic 34.84 18.32 7 511320 12202 110065770
Generalised oedema 34.82 18.32 55 511272 30649 110047323
Lung opacity 34.71 18.32 6 511321 11646 110066326
Injection site pruritus 34.67 18.32 121 511206 51137 110026835
Extra dose administered 34.64 18.32 7 511320 12152 110065820
Peripheral ischaemia 34.51 18.32 5 511322 11053 110066919
Lung consolidation 34.46 18.32 4 511323 10472 110067500
Influenza like illness 34.42 18.32 253 511074 88159 109989813
Pruritus 34.38 18.32 3129 508198 578431 109499541
Facial pain 34.21 18.32 14 511313 15325 110062647
Respiration abnormal 34.21 18.32 3 511324 9806 110068166
Oesophageal carcinoma 34.18 18.32 6 511321 11518 110066454
Arterial occlusive disease 34.10 18.32 14 511313 15294 110062678
Intentional dose omission 34.03 18.32 183 511144 19897 110058075
Diarrhoea haemorrhagic 33.72 18.32 15 511312 15624 110062348
Blood magnesium increased 33.48 18.32 62 511265 3761 110074211
Pulmonary thrombosis 33.48 18.32 140 511187 13723 110064249
Carotid artery thrombosis 33.47 18.32 3 511324 9635 110068337
Tension headache 33.38 18.32 3 511324 9615 110068357
Musculoskeletal chest pain 33.36 18.32 51 511276 28796 110049176
Refusal of treatment by patient 32.85 18.32 3 511324 9491 110068481
Ketoacidosis 32.82 18.32 4 511323 10083 110067889
Azotaemia 32.81 18.32 4 511323 10081 110067891
Drug eruption 32.73 18.32 386 510941 53273 110024699
Major depression 32.69 18.32 5 511322 10616 110067356
Colitis ischaemic 32.45 18.32 21 511306 17729 110060243
Cystitis 32.39 18.32 176 511151 65860 110012112
Dermatitis contact 32.33 18.32 12 511315 13941 110064031
Sinus disorder 32.26 18.32 64 511263 32664 110045308
Memory impairment 32.20 18.32 1163 510164 195781 109882191
Pancreatitis 32.09 18.32 277 511050 93256 109984716
Blood urine present 31.93 18.32 39 511288 24206 110053766
Grip strength 31.91 18.32 104 511223 9037 110068935
Organising pneumonia 31.77 18.32 13 511314 14230 110063742
Glucose tolerance impaired 31.76 18.32 4 511323 9833 110068139
Psychiatric symptom 31.64 18.32 3 511324 9210 110068762
Rash pustular 31.52 18.32 10 511317 12819 110065153
Affect lability 31.50 18.32 24 511303 18613 110059359
Skin cancer 31.46 18.32 164 511163 17620 110060352
Middle insomnia 31.45 18.32 29 511298 20473 110057499
Vitreous floaters 31.30 18.32 3 511324 9131 110068841
Dyspepsia 31.29 18.32 1128 510199 189837 109888135
Limb operation 31.24 18.32 62 511265 3962 110074010
Colorectal cancer 31.21 18.32 3 511324 9111 110068861
Ischaemia 31.08 18.32 3 511324 9080 110068892
Gingival pain 31.04 18.32 17 511310 15719 110062253
Haemoglobin abnormal 30.89 18.32 3 511324 9035 110068937
Ventricular hypokinesia 30.84 18.32 7 511320 11207 110066765
Pyelonephritis 30.80 18.32 43 511284 25207 110052765
Bladder cancer 30.78 18.32 29 511298 20263 110057709
Fracture delayed union 30.60 18.32 44 511283 2157 110075815
Cachexia 30.45 18.32 11 511316 12994 110064978
Central nervous system lesion 30.40 18.32 17 511310 15536 110062436
Paronychia 30.30 18.32 7 511320 11074 110066898
Choking 30.28 18.32 16 511311 15094 110062878
Personality change 29.99 18.32 7 511320 10995 110066977
Renal cyst 29.95 18.32 24 511303 18148 110059824
Skin disorder 29.91 18.32 100 511227 42813 110035159
Aortic valve incompetence 29.90 18.32 7 511320 10974 110066998
Blood pressure diastolic decreased 29.82 18.32 77 511250 35808 110042164
Overlap syndrome 29.79 18.32 101 511226 8958 110069014
Product dose omission in error 29.74 18.32 39 511288 23473 110054499
Pain assessment 29.61 18.32 10 511317 32 110077940
Eructation 29.50 18.32 14 511313 14043 110063929
Fibrin D dimer increased 29.48 18.32 5 511322 9840 110068132
Skin hyperpigmentation 29.42 18.32 3 511324 8693 110069279
Retching 29.33 18.32 37 511290 22645 110055327
Cardiac tamponade 29.26 18.32 8 511319 11299 110066673
Pre-eclampsia 29.23 18.32 3 511324 8647 110069325
BK virus infection 29.17 18.32 12 511315 13094 110064878
Transaminases abnormal 29.17 18.32 29 511298 959 110077013
Duodenitis 29.07 18.32 4 511323 9192 110068780
Muscle tightness 29.05 18.32 16 511311 14746 110063226
Atrial tachycardia 28.99 18.32 4 511323 9174 110068798
Faeces soft 28.89 18.32 8 511319 11202 110066770
Pneumonia bacterial 28.88 18.32 48 511279 26213 110051759
Muscle strain 28.85 18.32 8 511319 11194 110066778
Blood potassium increased 28.67 18.32 70 511257 33179 110044793
Escherichia bacteraemia 28.65 18.32 6 511321 10158 110067814
Cerebral atrophy 28.60 18.32 4 511323 9081 110068891
Immunosuppression 28.59 18.32 24 511303 17735 110060237
Spondylitis 28.56 18.32 116 511211 11222 110066750
Papule 28.52 18.32 6 511321 10127 110067845
Aplasia pure red cell 28.38 18.32 5 511322 9573 110068399
Prostate cancer 28.13 18.32 85 511242 37556 110040416
Intracranial pressure increased 28.13 18.32 7 511320 10528 110067444
Retinal haemorrhage 28.07 18.32 5 511322 9496 110068476
Hiatus hernia 28.06 18.32 53 511274 27553 110050419
Incoherent 27.98 18.32 3 511324 8355 110069617
Toothache 27.92 18.32 41 511286 23534 110054438
Wrong product administered 27.91 18.32 8 511319 10952 110067020
Mood swings 27.68 18.32 39 511288 22773 110055199
Gastric ulcer 27.62 18.32 93 511234 39734 110038238
Hypoxic-ischaemic encephalopathy 27.61 18.32 4 511323 8843 110069129
Skin irritation 27.60 18.32 21 511306 16298 110061674
Complication of device insertion 27.57 18.32 4 511323 8834 110069138
Spinal fusion surgery 27.44 18.32 99 511228 9057 110068915
Neutrophilia 27.32 18.32 7 511320 10322 110067650
Diverticulum intestinal 27.29 18.32 10 511317 11709 110066263
Device issue 27.26 18.32 76 511251 34459 110043513
Insomnia 27.24 18.32 1977 509350 358613 109719359
Atrioventricular block second degree 27.22 18.32 3 511324 8178 110069794
Blindness unilateral 27.13 18.32 6 511321 9780 110068192
Emotional disorder 27.07 18.32 21 511306 16139 110061833
Pulmonary function test decreased 26.99 18.32 4 511323 8696 110069276
Short stature 26.85 18.32 29 511298 1058 110076914
Bronchiectasis 26.85 18.32 83 511244 36410 110041562
Abscess 26.83 18.32 54 511273 27415 110050557
Intervertebral disc space narrowing 26.50 18.32 38 511289 1858 110076114
Feeding disorder 26.44 18.32 36 511291 21326 110056646
Visual field defect 26.31 18.32 7 511320 10065 110067907
Ocular discomfort 26.30 18.32 4 511323 8529 110069443
Pneumatosis intestinalis 26.28 18.32 4 511323 8525 110069447
Vitamin B12 deficiency 26.24 18.32 7 511320 10048 110067924
Pseudomonal sepsis 26.21 18.32 5 511322 9041 110068931
Swollen joint count 26.18 18.32 94 511233 8580 110069392
Hepatic lesion 26.13 18.32 4 511323 8489 110069483
Shoulder arthroplasty 26.13 18.32 54 511273 3553 110074419
Necrosis 26.11 18.32 10 511317 11396 110066576
Chest X-ray abnormal 26.11 18.32 4 511323 8483 110069489
Left ventricular failure 26.05 18.32 10 511317 11379 110066593
Cardiopulmonary failure 26.04 18.32 3 511324 7900 110070072
Pulmonary mass 25.94 18.32 87 511240 37214 110040758
Ulcer haemorrhage 25.86 18.32 186 511141 22385 110055587
Cartilage atrophy 25.71 18.32 14 511313 175 110077797
Hydrocephalus 25.64 18.32 8 511319 10367 110067605
Investigation abnormal 25.61 18.32 43 511284 2413 110075559
Sensitivity to weather change 25.58 18.32 103 511224 9925 110068047
Anal fissure 25.56 18.32 7 511320 9874 110068098
Odynophagia 25.35 18.32 17 511310 14084 110063888
Antibody test positive 25.34 18.32 49 511278 3071 110074901
Restless legs syndrome 25.28 18.32 47 511280 24579 110053393
Breast cancer metastatic 25.27 18.32 10 511317 11171 110066801
Diastolic dysfunction 25.06 18.32 13 511314 12391 110065581
Exposure via skin contact 24.80 18.32 15 511312 13132 110064840
Influenza 24.67 18.32 594 510733 168507 109909465
Haemorrhoidal haemorrhage 24.48 18.32 4 511323 8089 110069883
Supraventricular extrasystoles 24.39 18.32 4 511323 8069 110069903
Peripheral vascular disorder 24.30 18.32 5 511322 8571 110069401
Device breakage 24.22 18.32 17 511310 13752 110064220
Occult blood positive 24.10 18.32 3 511324 7442 110070530
Peroneal nerve palsy 23.97 18.32 3 511324 7411 110070561
Product contamination physical 23.90 18.32 16 511311 297 110077675
Tearfulness 23.89 18.32 3 511324 7392 110070580
Pharyngitis streptococcal 23.88 18.32 16 511311 13261 110064711
Urosepsis 23.85 18.32 68 511259 30607 110047365
Depressive symptom 23.65 18.32 5 511322 8409 110069563
Catarrh 23.64 18.32 3 511324 7332 110070640
Hypertonia 23.61 18.32 5 511322 8401 110069571
Cytomegalovirus infection reactivation 23.61 18.32 30 511297 18303 110059669
Skin lesion 23.49 18.32 141 511186 51490 110026482
Soft tissue disorder 23.49 18.32 51 511276 3473 110074499
Laryngeal oedema 23.47 18.32 8 511319 9799 110068173
Skin abrasion 23.44 18.32 24 511303 16127 110061845
Gastrointestinal motility disorder 23.39 18.32 3 511324 7273 110070699
Performance status decreased 23.35 18.32 3 511324 7263 110070709
Intestinal polyp 23.32 18.32 41 511286 2388 110075584
Bone density abnormal 23.23 18.32 54 511273 3849 110074123
Blood folate decreased 23.18 18.32 40 511287 2295 110075677
Rhinitis 23.17 18.32 43 511284 22502 110055470
Hypercalcaemia 23.11 18.32 323 511004 46334 110031638
Metastasis 23.06 18.32 5 511322 8262 110069710
Amenorrhoea 23.03 18.32 7 511320 9224 110068748
Liver abscess 23.02 18.32 4 511323 7735 110070237
Autoimmune haemolytic anaemia 23.00 18.32 10 511317 10557 110067415
Breast cancer 22.96 18.32 276 511051 38266 110039706
Injection site induration 22.89 18.32 12 511315 11371 110066601
Rhinovirus infection 22.88 18.32 13 511314 11776 110066196
Cardiovascular disorder 22.87 18.32 44 511283 22716 110055256
Vasculitic rash 22.85 18.32 39 511288 2218 110075754
C-reactive protein decreased 22.80 18.32 45 511282 2864 110075108
Embolism 22.75 18.32 25 511302 16264 110061708
Candida infection 22.43 18.32 130 511197 47879 110030093
Foot fracture 22.41 18.32 198 511129 25348 110052624
Tendonitis 22.28 18.32 201 511126 25882 110052090
Needle issue 22.19 18.32 150 511177 17690 110060282
Erythema 22.15 18.32 1111 510216 290336 109787636
Guillain-Barre syndrome 22.09 18.32 11 511316 10733 110067239
Infusion site swelling 22.05 18.32 9 511318 9868 110068104
Ischaemic cardiomyopathy 22.03 18.32 5 511322 8006 110069966
Headache 22.00 18.32 4509 506818 877868 109200104
Uterine disorder 22.00 18.32 39 511288 2287 110075685
Conjunctivitis allergic 21.94 18.32 3 511324 6928 110071044
Cytomegalovirus viraemia 21.92 18.32 30 511297 17734 110060238
Anal fistula 21.92 18.32 6 511321 8467 110069505
Steroid dependence 21.90 18.32 6 511321 8463 110069509
Sensation of foreign body 21.88 18.32 5 511322 7970 110070002
Blood pressure systolic decreased 21.84 18.32 18 511309 13423 110064549
Oesophageal ulcer 21.84 18.32 5 511322 7959 110070013
Viral infection 21.69 18.32 150 511177 52989 110024983
Appetite disorder 21.65 18.32 9 511318 9760 110068212
Photophobia 21.64 18.32 55 511272 25716 110052256
Back disorder 21.47 18.32 168 511159 20754 110057218
Expired product administered 21.32 18.32 6 511321 8314 110069658
Rheumatoid factor 21.23 18.32 19 511308 549 110077423
Embolic stroke 21.15 18.32 7 511320 8736 110069236
Streptococcal infection 21.14 18.32 12 511315 10878 110067094
Hepatic cyst 21.12 18.32 5 511322 7778 110070194
Back pain 21.07 18.32 1454 509873 369542 109708430
Hepatic enzyme 21.05 18.32 62 511265 5101 110072871
Hypertransaminasaemia 20.96 18.32 51 511276 24204 110053768
Therapy change 20.92 18.32 10 511317 9987 110067985
Wrong patient received product 20.87 18.32 3 511324 6671 110071301
Epstein-Barr virus infection 20.84 18.32 34 511293 18704 110059268
Macular degeneration 20.79 18.32 43 511284 21616 110056356
Dyslipidaemia 20.69 18.32 26 511301 15939 110062033
Spinal meningioma benign 20.65 18.32 10 511317 96 110077876
Device related sepsis 20.58 18.32 5 511322 7642 110070330
Flank pain 20.50 18.32 48 511279 23082 110054890
Product distribution issue 20.48 18.32 55 511272 4291 110073681
Retinal detachment 20.47 18.32 13 511314 11087 110066885
Respiratory tract infection 20.38 18.32 222 511105 71395 110006577
Neutropenic colitis 20.33 18.32 6 511321 8059 110069913
Sluggishness 20.26 18.32 5 511322 7562 110070410
Vasculitis 20.24 18.32 91 511236 35782 110042190
Skin reaction 20.19 18.32 167 511160 20977 110056995
Lesion excision 20.17 18.32 11 511316 138 110077834
Tendon disorder 19.98 18.32 84 511243 8253 110069719
Oral pain 19.94 18.32 97 511230 37347 110040625
Extremity contracture 19.94 18.32 32 511295 1729 110076243
Liver function test abnormal 19.91 18.32 213 511114 68737 110009235
Macular oedema 19.87 18.32 4 511323 6962 110071010
Procedural complication 19.86 18.32 7 511320 8398 110069574
Ventricular arrhythmia 19.75 18.32 11 511316 10076 110067896
Intermenstrual bleeding 19.74 18.32 4 511323 6930 110071042
Ecchymosis 19.71 18.32 31 511296 17307 110060665
Precancerous cells present 19.69 18.32 27 511300 1266 110076706
Gestational diabetes 19.56 18.32 5 511322 7384 110070588
Extrasystoles 19.54 18.32 7 511320 8311 110069661
Gait disturbance 19.43 18.32 1516 509811 276692 109801280
Nerve block 19.41 18.32 21 511306 768 110077204
Respiratory syncytial virus infection 19.39 18.32 23 511304 14461 110063511
Mucous stools 19.38 18.32 4 511323 6843 110071129
Carotid artery occlusion 19.36 18.32 10 511317 9555 110068417
Hepatic cancer 19.33 18.32 14 511313 11142 110066830
Haemarthrosis 19.32 18.32 5 511322 7324 110070648
Clostridial infection 19.32 18.32 3 511324 6299 110071673
Lichenoid keratosis 19.32 18.32 3 511324 6299 110071673
Oesophageal candidiasis 19.30 18.32 15 511312 11519 110066453
Cerebral disorder 19.30 18.32 4 511323 6822 110071150
Intercepted product preparation error 19.28 18.32 4 511323 6816 110071156
Lacunar infarction 19.25 18.32 3 511324 6283 110071689
Anaemia macrocytic 19.22 18.32 5 511322 7298 110070674
Device use error 19.16 18.32 9 511318 9080 110068892
Pustular psoriasis 19.14 18.32 118 511209 13487 110064485
Herpes simplex 19.08 18.32 27 511300 15737 110062235
Iron deficiency anaemia 19.07 18.32 78 511249 31481 110046491
Femoral neck fracture 19.01 18.32 18 511309 12549 110065423
Subcutaneous drug absorption impaired 19.01 18.32 78 511249 7581 110070391
Escherichia sepsis 18.99 18.32 12 511315 10260 110067712
Blood thyroid stimulating hormone decreased 18.97 18.32 5 511322 7234 110070738
Multiple allergies 18.94 18.32 109 511218 12154 110065818
Phlebitis 18.88 18.32 11 511316 9830 110068142
Catheterisation cardiac 18.86 18.32 3 511324 6188 110071784
Blood pressure diastolic abnormal 18.79 18.32 59 511268 25756 110052216
Post procedural complication 18.66 18.32 62 511265 26596 110051376
Renal function test abnormal 18.64 18.32 9 511318 8937 110069035
Limb injury 18.62 18.32 100 511227 37536 110040436
Bedridden 18.61 18.32 116 511211 13309 110064663
Spinal osteoarthritis 18.60 18.32 41 511286 20142 110057830
Aortic arteriosclerosis 18.59 18.32 14 511313 10924 110067048
Hereditary angioedema 18.47 18.32 5 511322 7109 110070863
Hypogammaglobulinaemia 18.32 18.32 41 511286 20035 110057937

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
ATC L04AA24 ANTINEOPLASTIC AND IMMUNOMODULATING AGENTS
IMMUNOSUPPRESSANTS
IMMUNOSUPPRESSANTS
Selective immunosuppressants
FDA CS M0018640 Recombinant Fusion Proteins
FDA PE N0000008571 Decreased Cytokine Activity
MeSH PA D000074322 Antineoplastic Agents, Immunological
MeSH PA D000082082 Immune Checkpoint Inhibitors
MeSH PA D000970 Antineoplastic Agents
MeSH PA D007155 Immunologic Factors
MeSH PA D007166 Immunosuppressive Agents
MeSH PA D018501 Antirheumatic Agents
FDA EPC N0000182159 Selective T Cell Costimulation Modulator
CHEBI has role CHEBI:22587 antiviral agent
CHEBI has role CHEBI:35526 hypoglycemic agent
CHEBI has role CHEBI:35610 antineoplastic agent
CHEBI has role CHEBI:35674 antihypertensive agent
CHEBI has role CHEBI:35705 immunosuppressive agent
CHEBI has role CHEBI:35842 antirheumatic drug
CHEBI has role CHEBI:50748 antipsoriatic
CHEBI has role CHEBI:66981 ophthalmology drug
CHEBI has role CHEBI:67079 anti-inflammatory agent
CHEBI has role CHEBI:75835 anti-anaemic agent

Related Drugs by ATC class:

L04AA Selective immunosuppressants 10 drugs
alefaceptapremilastbelataceptbelumosudilcladribinegusperimusimlifidasemycophenolic acidnerandomilastremibrutinib

Drug Use | Suggest Off label Use Form| |View source of the data|

DiseaseRelationSNOMED_IDDOID
Rheumatoid arthritis indication 69896004 DOID:7148
Juvenile idiopathic arthritis indication 410502007




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

None

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])		Mechanism
action		Bioact sourceMoA source
T-lymphocyte activation antigen CD80 Surface antigen INHIBITOR Kd 7.92 IUPHAR DRUG LABEL
T-lymphocyte activation antigen CD86 Surface antigen INHIBITOR Kd 7.92 IUPHAR DRUG LABEL

External reference:

IDSource
7D0YB67S97 UNII
D03203 KEGG_DRUG
4025085 VANDF
C1619966 UMLSCUI
CHEBI:749599 CHEBI
CHEMBL1201823 ChEMBL_ID
DB01281 DRUGBANK_ID
D000069594 MESH_DESCRIPTOR_UI
8495 INN_ID
6891 IUPHAR_LIGAND_ID
614391 RXNORM
20795 MMSL
73627 MMSL
d05694 MMSL
011175 NDDF
421412005 SNOMEDCT_US
421777009 SNOMEDCT_US

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
ORENCIA HUMAN PRESCRIPTION DRUG LABEL 1 0003-2187 INJECTION, POWDER, LYOPHILIZED, FOR SOLUTION 250 mg INTRAVENOUS BLA 29 sections
ORENCIA HUMAN PRESCRIPTION DRUG LABEL 1 0003-2188 INJECTION, SOLUTION 125 mg SUBCUTANEOUS BLA 29 sections
ORENCIA HUMAN PRESCRIPTION DRUG LABEL 1 0003-2814 INJECTION, SOLUTION 50 mg SUBCUTANEOUS BLA 29 sections
ORENCIA HUMAN PRESCRIPTION DRUG LABEL 1 0003-2818 INJECTION, SOLUTION 87.50 mg SUBCUTANEOUS BLA 29 sections