All FDA-approved EMA-approved PMDA-approved
Target Card Uniprot Example: P23975

abatacept 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definition	Drug id	CAS RN
cytotoxic T lymphocyte-associated antigen 4 (CTLA-4) receptors	5089	332348-12-6

Description:

Molecule	Description
Synonyms: abatacept orencia BMS-188667 BMS 188667	A fusion protein immunoconjugate of the extracellular domain of CTLA4 and the Fc domain of human IgG1. It functions as a T-cell co-stimulation blocker that inhibits TNF-ALPHA and prevents the activation of T-LYMPHOCYTES. It is used in the treatment of RHEUMATOID ARTHRITIS. Molecular weight: Formula: CLOGP: LIPINSKI: None HAC: None HDO: None TPSA: ALOGS: ROTB: None

Drug dosage:

Dose	Unit	Route
27	mg	P

ADMET properties:

None

Approvals:

Date	Agency	Company	Orphan
Dec. 23, 2005	FDA	BRISTOL MYERS SQUIBB
Feb. 21, 2020	PMDA	Bristol-Myers Squibb K.K.

FDA Adverse Event Reporting System (Female)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Drug ineffective	7425.85	19.13	18569	382401	1026196	62061856
Contraindicated product administered	6669.73	19.13	7513	393457	210135	62877917
Joint swelling	5586.13	19.13	8469	392501	319197	62768855
Drug intolerance	3790.42	19.13	6891	394079	301770	62786282
Synovitis	3666.24	19.13	5170	395800	181748	62906304
Treatment failure	3537.42	19.13	5254	395716	193789	62894263
Arthropathy	3358.83	19.13	5610	395360	229182	62858870
Therapeutic product effect decreased	2705.91	19.13	4575	396395	188612	62899440
Pemphigus	2632.87	19.13	4396	396574	179330	62908722
Systemic lupus erythematosus	2472.62	19.13	4596	396374	204322	62883730
Arthralgia	2401.72	19.13	8461	392509	561249	62526803
Pain	2197.54	19.13	9851	391119	730777	62357275
Glossodynia	2183.41	19.13	3989	396981	174887	62913165
Hand deformity	2112.65	19.13	3686	397284	155771	62932281
Swelling	2049.72	19.13	5016	395954	270362	62817690
Alopecia	1787.76	19.13	5425	395545	332111	62755941
Abdominal discomfort	1752.57	19.13	5214	395756	315671	62772381
Rheumatoid arthritis	1586.99	19.13	4332	396638	249487	62838565
Hypersensitivity	1561.69	19.13	4718	396252	287967	62800085
Hepatic enzyme increased	1455.27	19.13	3640	397330	198688	62889364
Wound	1425.94	19.13	3169	397801	160094	62927958
Infection	1286.54	19.13	3763	397207	225410	62862642
Anti-cyclic citrullinated peptide antibody positive	1274.91	19.13	2478	398492	113734	62974318
Rheumatoid factor positive	1212.22	19.13	2024	398946	82382	63005670
Acute kidney injury	1180.01	19.13	140	400830	263275	62824777
Pericarditis	1148.32	19.13	2554	398416	129025	62959027
C-reactive protein abnormal	1146.83	19.13	1435	399535	44661	63043391
Rash	1088.53	19.13	6643	394327	554228	62533824
Hypotension	1043.63	19.13	224	400746	272380	62815672
Anaemia	1028.35	19.13	290	400680	293140	62794912
Red blood cell sedimentation rate abnormal	1022.65	19.13	910	400060	18872	63069180
Drug interaction	972.94	19.13	144	400826	228987	62859065
Discomfort	963.10	19.13	2774	398196	164600	62923452
Toxicity to various agents	897.06	19.13	228	400742	247022	62841030
Musculoskeletal stiffness	869.45	19.13	2853	398117	181765	62906287
Lower respiratory tract infection	865.04	19.13	2298	398672	130009	62958043
Muscle injury	853.83	19.13	1503	399467	63842	63024210
Death	853.15	19.13	670	400300	373711	62714341
Folliculitis	851.95	19.13	1565	399405	68752	63019300
Product use issue	847.20	19.13	3186	397784	217334	62870718
Helicobacter infection	782.13	19.13	1777	399193	91008	62997044
Irritable bowel syndrome	771.19	19.13	1646	399324	80766	63007286
Impaired healing	762.43	19.13	1870	399100	100672	62987380
Duodenal ulcer perforation	756.03	19.13	1689	399281	85520	63002532
Peripheral swelling	735.13	19.13	3475	397495	262467	62825585
Dehydration	695.42	19.13	127	400843	173227	62914825
Febrile neutropenia	687.16	19.13	12	400958	118437	62969615
Ill-defined disorder	670.42	19.13	1549	399421	80206	63007846
Infusion related reaction	669.52	19.13	3196	397774	242325	62845727
Maternal exposure during pregnancy	648.82	19.13	2931	398039	217131	62870921
Constipation	620.72	19.13	323	400647	224620	62863432
Loss of personal independence in daily activities	618.62	19.13	1673	399297	95617	62992435
Drug hypersensitivity	607.70	19.13	3692	397278	306995	62781057
Blister	606.05	19.13	2001	398969	127813	62960239
Seizure	597.14	19.13	69	400901	132565	62955487
Adverse event	596.17	19.13	1318	399652	66241	63021811
Sleep disorder due to general medical condition, insomnia type	592.23	19.13	1130	399840	51087	63036965
Hyponatraemia	567.09	19.13	35	400935	111865	62976187
Tremor	561.24	19.13	83	400887	132156	62955896
Somnolence	535.27	19.13	229	400741	178456	62909596
Red blood cell sedimentation rate increased	526.37	19.13	974	399996	43008	63045044
Anxiety	521.07	19.13	369	400601	217172	62870880
Therapy interrupted	516.78	19.13	816	400154	31639	63056413
Dizziness	506.09	19.13	1240	399730	428685	62659367
Nausea	503.73	19.13	3251	397719	851220	62236832
Mobility decreased	492.63	19.13	1784	399186	119375	62968677
Gastrointestinal disorder	492.40	19.13	1883	399087	129356	62958696
Tachycardia	464.28	19.13	91	400879	118065	62969987
Knee arthroplasty	463.02	19.13	1044	399926	53162	63034890
Cardiac arrest	459.90	19.13	32	400938	92513	62995539
Condition aggravated	458.11	19.13	4205	396765	398012	62690040
Thrombocytopenia	453.83	19.13	193	400777	150964	62937088
Sinusitis	435.37	19.13	2682	398288	223971	62864081
Therapeutic product effect incomplete	434.04	19.13	1751	399219	123305	62964747
Dyspnoea	428.34	19.13	2441	398529	658872	62429180
Abdominal pain	421.84	19.13	755	400215	292701	62795351
Drug abuse	417.87	19.13	8	400962	72510	63015542
Platelet count decreased	415.17	19.13	110	400860	116012	62972040
Neutropenia	410.95	19.13	303	400667	174702	62913350
Diarrhoea	402.63	19.13	2758	398212	712608	62375444
Device malfunction	400.06	19.13	528	400442	17329	63070723
Respiratory failure	399.02	19.13	79	400891	101779	62986273
Rheumatic fever	397.22	19.13	856	400114	42255	63045797
Chest discomfort	393.48	19.13	104	400866	109865	62978187
Pancytopenia	392.93	19.13	69	400901	96864	62991188
Bradycardia	392.90	19.13	16	400954	73211	63014841
Renal failure	386.89	19.13	130	400840	117522	62970530
Stomatitis	381.96	19.13	1812	399158	136913	62951139
Gastrointestinal haemorrhage	381.34	19.13	36	400934	81140	63006912
Haemoglobin decreased	379.26	19.13	224	400746	145261	62942791
Rheumatoid nodule	377.78	19.13	503	400467	16652	63071400
Balance disorder	374.76	19.13	46	400924	84376	63003676
Pulmonary embolism	373.26	19.13	135	400835	116549	62971503
Hip arthroplasty	369.97	19.13	884	400086	46762	63041290
Dysphagia	361.38	19.13	62	400908	88523	62999529
Cardio-respiratory arrest	356.65	19.13	4	400966	59955	63028097
Depressed level of consciousness	353.11	19.13	8	400962	62070	63025982
Malignant neoplasm progression	351.96	19.13	50	400920	82071	63005981
Injection site pain	351.02	19.13	191	400779	129609	62958443
C-reactive protein increased	349.44	19.13	1352	399618	93355	62994697
Asthenia	347.91	19.13	1249	399721	382355	62705697
Neuropathy peripheral	347.81	19.13	141	400829	113526	62974526
Suicide attempt	345.93	19.13	8	400962	60910	63027142
White blood cell count decreased	343.50	19.13	228	400742	138876	62949176
Oedema peripheral	334.66	19.13	423	400547	189088	62898964
Overdose	329.61	19.13	157	400813	114921	62973131
Decreased appetite	325.82	19.13	686	400284	250366	62837686
Disease progression	324.21	19.13	186	400784	122572	62965480
Coma	323.46	19.13	21	400949	64343	63023709
Sepsis	317.65	19.13	299	400671	152824	62935228
Hyperkalaemia	316.33	19.13	5	400965	54198	63033854
Sleep disorder	315.38	19.13	1182	399788	80384	63007668
Epistaxis	314.67	19.13	43	400927	72682	63015370
Swollen joint count increased	311.87	19.13	698	400272	35356	63052696
Hallucination	308.20	19.13	8	400962	54809	63033243
Inflammation	307.99	19.13	1180	399790	81093	63006959
Vision blurred	304.96	19.13	100	400870	91824	62996228
Palpitations	304.82	19.13	166	400804	112604	62975448
Hypoglycaemia	303.62	19.13	19	400951	60046	63028006
Vomiting	300.34	19.13	2186	398784	557431	62530621
Hypokalaemia	299.77	19.13	140	400830	103664	62984388
Hypoxia	296.10	19.13	21	400949	59771	63028281
Weight decreased	295.00	19.13	838	400132	275960	62812092
Feeling abnormal	294.82	19.13	301	400669	148091	62939961
Blood cholesterol increased	291.31	19.13	1272	399698	92760	62995292
Deformity	290.81	19.13	364	400606	11320	63076732
Intentional product use issue	290.62	19.13	1583	399387	126309	62961743
Fall	290.45	19.13	1382	399588	390952	62697100
Agitation	290.21	19.13	23	400947	59734	63028318
Bone erosion	279.99	19.13	444	400526	17273	63070779
Psoriatic arthropathy	278.18	19.13	1231	399739	90289	62997763
Oxygen saturation decreased	277.39	19.13	106	400864	88479	62999573
Multiple sclerosis relapse	272.83	19.13	7	400963	48471	63039581
Dyspnoea exertional	272.23	19.13	31	400939	60271	63027781
Myalgia	271.42	19.13	315	400655	146214	62941838
Cognitive disorder	269.61	19.13	22	400948	55793	63032259
Cardiac failure congestive	269.48	19.13	123	400847	92310	62995742
Product dose omission issue	268.76	19.13	684	400286	233629	62854423
Nasopharyngitis	268.75	19.13	2618	398352	251639	62836413
Drug tolerance decreased	268.05	19.13	432	400538	17041	63071011
Cough	267.96	19.13	949	400021	291794	62796258
Multiple organ dysfunction syndrome	266.99	19.13	25	400945	56727	63031325
Chest pain	263.78	19.13	610	400360	215349	62872703
Foot deformity	263.40	19.13	559	400411	27294	63060758
International normalised ratio increased	260.16	19.13	7	400963	46418	63041634
Blood glucose increased	257.67	19.13	103	400867	83653	63004399
Suicidal ideation	256.10	19.13	43	400927	62378	63025674
Neutrophil count decreased	254.63	19.13	29	400941	56377	63031675
Blood pressure increased	253.88	19.13	394	400576	161668	62926384
Rhabdomyolysis	252.59	19.13	5	400965	43946	63044106
Chills	247.55	19.13	211	400759	113167	62974885
Syncope	247.21	19.13	226	400744	117159	62970893
Wrong technique in product usage process	236.59	19.13	52	400918	62288	63025764
Fibromyalgia	234.84	19.13	1069	399901	79351	63008701
Arthritis	234.46	19.13	1391	399579	114530	62973522
Heart rate increased	233.22	19.13	154	400816	94084	62993968
Metabolic acidosis	231.61	19.13	13	400957	45056	63042996
Disability	230.44	19.13	415	400555	17932	63070120
Dysarthria	230.23	19.13	9	400961	42702	63045350
Flushing	229.90	19.13	93	400877	74994	63013058
Pleural effusion	228.41	19.13	154	400816	93056	62994996
Cerebrovascular accident	227.45	19.13	208	400762	107816	62980236
Gastrooesophageal reflux disease	226.45	19.13	164	400806	95475	62992577
Musculoskeletal pain	225.16	19.13	1165	399805	91112	62996940
Panniculitis	223.79	19.13	316	400654	11069	63076983
Deep vein thrombosis	222.62	19.13	126	400844	83674	63004378
Blood pressure decreased	222.32	19.13	67	400903	64955	63023097
Ascites	221.53	19.13	8	400962	40720	63047332
Rectal haemorrhage	219.34	19.13	26	400944	49004	63039048
Blood bilirubin increased	218.55	19.13	3	400967	37137	63050915
Type 2 diabetes mellitus	217.99	19.13	890	400080	62978	63025074
Neoplasm progression	214.11	19.13	3	400967	36425	63051627
Incorrect dose administered	213.92	19.13	57	400913	59911	63028141
Blood parathyroid hormone decreased	213.91	19.13	286	400684	9505	63078547
Disorientation	213.73	19.13	8	400962	39444	63048608
Coeliac disease	212.35	19.13	328	400642	12469	63075583
Muscle spasms	209.79	19.13	418	400552	155732	62932320
Cardiac failure	209.56	19.13	154	400816	88988	62999064
Lethargy	207.98	19.13	49	400921	55958	63032094
Granuloma skin	205.45	19.13	260	400710	8177	63079875
Encephalopathy	205.28	19.13	9	400961	38611	63049441
Injection site erythema	201.68	19.13	139	400831	83035	63005017
Product storage error	201.66	19.13	349	400621	14607	63073445
Dysgeusia	201.16	19.13	28	400942	46682	63041370
Disturbance in attention	196.29	19.13	11	400959	38178	63049874
Hyperglycaemia	195.46	19.13	19	400951	41848	63046204
Liver injury	193.75	19.13	827	400143	59693	63028359
Unresponsive to stimuli	193.71	19.13	4	400966	33812	63054240
Pulmonary oedema	190.42	19.13	55	400915	54818	63033234
Blood alkaline phosphatase increased	189.23	19.13	24	400946	42943	63045109
Pulmonary fibrosis	188.50	19.13	617	400353	39192	63048860
Swelling face	185.73	19.13	84	400886	63391	63024661
Bone pain	185.55	19.13	57	400913	54584	63033468
Fracture	183.96	19.13	392	400578	19192	63068860
Osteoarthritis	183.80	19.13	1130	399840	94213	62993839
Depression	182.98	19.13	632	400338	195860	62892192
Osteoporosis	177.02	19.13	775	400195	56563	63031489
Haemorrhage	176.61	19.13	82	400888	60940	63027112
Haematochezia	174.51	19.13	60	400910	53484	63034568
Atrial fibrillation	173.75	19.13	293	400677	116343	62971709
Full blood count abnormal	173.31	19.13	6	400964	31711	63056341
Hepatic failure	172.35	19.13	14	400956	35642	63052410
Paraesthesia	171.65	19.13	469	400501	156497	62931555
Fatigue	170.10	19.13	7034	393936	880994	62207058
Dry skin	170.04	19.13	73	400897	56814	63031238
Skin exfoliation	169.65	19.13	33	400937	43069	63044983
Joint range of motion decreased	168.52	19.13	519	400451	31909	63056143
Drug reaction with eosinophilia and systemic symptoms	167.19	19.13	12	400958	33824	63054228
Hypomagnesaemia	166.22	19.13	3	400967	28734	63059318
Dyskinesia	165.15	19.13	9	400961	31993	63056059
Aphasia	165.11	19.13	11	400959	32989	63055063
Depressed mood	164.17	19.13	28	400942	40163	63047889
Hepatic function abnormal	162.95	19.13	21	400949	37121	63050931
Joint stiffness	160.31	19.13	605	400365	41264	63046788
Respiratory distress	159.57	19.13	15	400955	33936	63054116
Emotional distress	159.52	19.13	12	400958	32537	63055515
Premature delivery	157.89	19.13	8	400962	30273	63057779
Inappropriate schedule of product administration	157.80	19.13	258	400712	103707	62984345
Vertigo	157.68	19.13	91	400879	59796	63028256
Orthostatic hypotension	157.31	19.13	21	400949	36139	63051913
Respiratory arrest	157.29	19.13	13	400957	32632	63055420
Finger deformity	156.74	19.13	218	400752	7527	63080525
Thrombosis	155.95	19.13	109	400861	64646	63023406
Plasma cell myeloma	155.85	19.13	21	400949	35884	63052168
Blood potassium decreased	155.58	19.13	37	400933	41989	63046063
Haematemesis	155.57	19.13	9	400961	30403	63057649
Jaundice	154.87	19.13	7	400963	29244	63058808
Hypophagia	154.70	19.13	11	400959	31248	63056804
Pulmonary hypertension	153.55	19.13	25	400945	37098	63050954
Tenosynovitis	153.20	19.13	296	400674	13499	63074553
Hypervolaemia	153.09	19.13	6	400964	28407	63059645
Blood urea increased	151.58	19.13	3	400967	26376	63061676
Foetal exposure during pregnancy	150.54	19.13	14	400956	31948	63056104
Hepatocellular injury	150.25	19.13	5	400965	27376	63060676
Abdominal distension	148.98	19.13	197	400773	86418	63001634
Intentional self-injury	147.29	19.13	3	400967	25684	63062368
Drug withdrawal syndrome	145.66	19.13	6	400964	27188	63060864
Intentional product misuse	144.78	19.13	104	400866	60813	63027239
Mental status changes	144.37	19.13	36	400934	39563	63048489
Skin ulcer	143.83	19.13	596	400374	42449	63045603
Swollen tongue	142.68	19.13	24	400946	34776	63053276
Pallor	142.36	19.13	14	400956	30554	63057498
Haematuria	142.19	19.13	11	400959	29146	63058906
Joint destruction	141.78	19.13	186	400784	6066	63081986
Irritability	141.29	19.13	17	400953	31677	63056375
Restlessness	141.16	19.13	12	400958	29441	63058611
Blood calcium decreased	141.13	19.13	6	400964	26445	63061607
Colitis	140.76	19.13	65	400905	48463	63039589
Osteonecrosis of jaw	140.13	19.13	26	400944	35097	63052955
Arthrodesis	139.08	19.13	126	400844	2675	63085377
Urinary retention	138.22	19.13	15	400955	30286	63057766
Acute respiratory failure	136.58	19.13	26	400944	34459	63053593
Speech disorder	135.07	19.13	44	400926	40585	63047467
Urinary tract infection	134.79	19.13	1048	399922	263636	62824416
Basal cell carcinoma	134.46	19.13	436	400534	27555	63060497
Skin necrosis	133.07	19.13	281	400689	13669	63074383
Elbow deformity	132.64	19.13	95	400875	1420	63086632
Device defective	131.78	19.13	105	400865	1857	63086195
Blood creatine phosphokinase increased	131.60	19.13	18	400952	30412	63057640
Pneumonia aspiration	130.67	19.13	29	400941	34511	63053541
Limb deformity	130.12	19.13	143	400827	3859	63084193
Abortion spontaneous	129.64	19.13	68	400902	47127	63040925
Full blood count decreased	129.24	19.13	9	400961	26015	63062037
Haemoptysis	129.06	19.13	15	400955	28711	63059341
Stevens-Johnson syndrome	128.80	19.13	7	400963	24943	63063109
Mucosal inflammation	128.34	19.13	68	400902	46860	63041192
Generalised tonic-clonic seizure	128.28	19.13	16	400954	29000	63059052
Chronic obstructive pulmonary disease	128.04	19.13	124	400846	62562	63025490
Musculoskeletal disorder	128.04	19.13	352	400618	20292	63067760
Gamma-glutamyltransferase increased	127.88	19.13	29	400941	34002	63054050
Musculoskeletal deformity	127.88	19.13	102	400868	1807	63086245
Muscle spasticity	127.70	19.13	364	400606	21430	63066622
Cholestasis	125.90	19.13	18	400952	29416	63058636
Accidental overdose	125.32	19.13	5	400965	23304	63064748
Urinary incontinence	124.97	19.13	25	400945	31989	63056063
Prescribed underdose	124.61	19.13	442	400528	29247	63058805
Blood lactate dehydrogenase increased	124.15	19.13	5	400965	23111	63064941
Hyperhidrosis	124.10	19.13	314	400656	107522	62980530
Chronic kidney disease	123.83	19.13	66	400904	45332	63042720
Presyncope	123.62	19.13	15	400955	27770	63060282
Shock	122.97	19.13	6	400964	23457	63064595
Sciatica	122.43	19.13	485	400485	33839	63054213
Cerebral haemorrhage	122.06	19.13	23	400947	30706	63057346
Angioedema	121.90	19.13	76	400894	47889	63040163
Abnormal behaviour	120.91	19.13	3	400967	21423	63066629
Coronary artery disease	120.85	19.13	28	400942	32349	63055703
Prescribed overdose	120.55	19.13	481	400489	33672	63054380
Lymphocyte count decreased	119.43	19.13	23	400947	30234	63057818
Device dislocation	119.11	19.13	12	400958	25693	63062359
Blood creatinine increased	118.91	19.13	234	400736	87610	63000442
Pyrexia	118.89	19.13	2174	398796	468304	62619748
Temperature regulation disorder	118.75	19.13	169	400801	5963	63082089
Nasal congestion	118.46	19.13	144	400826	65516	63022536
Lip swelling	117.67	19.13	26	400944	31037	63057015
Pancreatitis acute	117.64	19.13	16	400954	27150	63060902
Grip strength decreased	117.01	19.13	358	400612	21929	63066123
Psychotic disorder	116.59	19.13	13	400957	25699	63062353
Altered state of consciousness	116.34	19.13	12	400958	25218	63062834
Crying	116.14	19.13	8	400962	23335	63064717
Nervousness	115.21	19.13	27	400943	30952	63057100
Adverse drug reaction	115.06	19.13	880	400090	78834	63009218
Metastases to bone	114.76	19.13	4	400966	21015	63067037
Night sweats	114.68	19.13	610	400360	48204	63039848
Aggression	114.20	19.13	9	400961	23489	63064563
Pericardial effusion	114.19	19.13	25	400945	30033	63058019
Liver function test increased	114.12	19.13	460	400510	32351	63055701
Bone marrow failure	114.07	19.13	23	400947	29267	63058785
Cholelithiasis	113.86	19.13	68	400902	43857	63044195
Circulatory collapse	113.74	19.13	6	400964	21932	63066120
Acute myocardial infarction	113.68	19.13	31	400939	32093	63055959
Ear pain	111.32	19.13	488	400482	35630	63052422
Drug ineffective for unapproved indication	111.29	19.13	38	400932	34025	63054027
Feeling hot	110.74	19.13	93	400877	50261	63037791
Panic attack	110.10	19.13	8	400962	22323	63065729
Premature baby	109.65	19.13	5	400965	20730	63067322
Acute respiratory distress syndrome	109.02	19.13	11	400959	23523	63064529
Coagulopathy	108.49	19.13	5	400965	20539	63067513
Ventricular tachycardia	108.39	19.13	4	400966	19975	63068077
Blood sodium decreased	108.13	19.13	13	400957	24239	63063813
Product prescribing error	108.07	19.13	18	400952	26271	63061781
Tubulointerstitial nephritis	107.93	19.13	4	400966	19899	63068153
SLE arthritis	107.74	19.13	62	400908	619	63087433
Drug eruption	107.67	19.13	412	400558	28282	63059770
Hemiparesis	107.54	19.13	11	400959	23271	63064781
Pneumonia	107.28	19.13	2137	398833	454630	62633422
Fine motor skill dysfunction	107.03	19.13	142	400828	4683	63083369
Rhinorrhoea	106.90	19.13	155	400815	65422	63022630
Pollakiuria	106.61	19.13	23	400947	27914	63060138
Vaginal haemorrhage	106.18	19.13	22	400948	27465	63060587
Leukocytosis	106.07	19.13	18	400952	25917	63062135
Agranulocytosis	106.05	19.13	16	400954	25118	63062934
Skin discolouration	104.65	19.13	54	400916	37774	63050278
Myocardial infarction	104.34	19.13	305	400665	99588	62988464
Pulmonary arterial hypertension	103.43	19.13	11	400959	22566	63065486
Pulmonary toxicity	102.70	19.13	201	400769	9254	63078798
Electrolyte imbalance	102.51	19.13	6	400964	20070	63067982
Body height below normal	102.16	19.13	95	400875	2088	63085964
Eosinophilia	101.94	19.13	12	400958	22744	63065308
Dysphonia	100.99	19.13	91	400879	47523	63040529
Obstructive airways disorder	100.40	19.13	8	400962	20691	63067361
Abdominal pain lower	100.34	19.13	20	400950	25658	63062394
Red blood cell sedimentation rate	100.28	19.13	138	400832	4716	63083336
Muscle twitching	100.05	19.13	6	400964	19662	63068390
Joint laxity	99.75	19.13	99	400871	2365	63085687
Immunodeficiency	99.56	19.13	318	400652	19936	63068116
Oral mucosal exfoliation	99.48	19.13	83	400887	1571	63086481
Human antichimeric antibody positive	98.95	19.13	84	400886	1630	63086422
Staphylococcal infection	98.60	19.13	70	400900	41186	63046866
Cellulitis	97.94	19.13	234	400736	81724	63006328
Sleep apnoea syndrome	97.81	19.13	31	400939	29102	63058950
Arrhythmia	97.52	19.13	60	400910	38080	63049972
Face oedema	97.51	19.13	8	400962	20204	63067848
Nightmare	97.20	19.13	6	400964	19188	63068864
Visual acuity reduced	96.57	19.13	12	400958	21814	63066238
Onychomycosis	96.53	19.13	177	400793	7755	63080297
Blood pressure fluctuation	96.49	19.13	90	400880	46227	63041825
Physical disability	96.01	19.13	102	400868	2646	63085406
Hypothyroidism	95.90	19.13	77	400893	42555	63045497
Cardiogenic shock	95.89	19.13	4	400966	17928	63070124
Tachypnoea	95.50	19.13	3	400967	17299	63070753
Hot flush	94.63	19.13	110	400860	51049	63037003
Wrist deformity	94.52	19.13	90	400880	2040	63086012
Therapeutic response decreased	93.75	19.13	688	400282	60837	63027215
Diplopia	93.73	19.13	18	400952	23710	63064342
Gastritis	93.56	19.13	60	400910	37243	63050809
Complication associated with device	93.51	19.13	3	400967	16975	63071077
Sinus tachycardia	92.56	19.13	20	400950	24248	63063804
Memory impairment	92.54	19.13	342	400628	103916	62984136
Dysuria	92.09	19.13	49	400921	33689	63054363
Frequent bowel movements	91.93	19.13	17	400953	23005	63065047
Device related infection	91.86	19.13	18	400952	23374	63064678
Clostridium difficile colitis	91.77	19.13	11	400959	20558	63067494
Therapeutic response unexpected	91.69	19.13	7	400963	18752	63069300
Disseminated intravascular coagulation	90.65	19.13	8	400962	19043	63069009
Feeling cold	90.48	19.13	20	400950	23868	63064184
Hypersomnia	90.37	19.13	6	400964	18049	63070003
Mental disorder	89.88	19.13	26	400944	25893	63062159
Flatulence	89.55	19.13	54	400916	34648	63053404
Upper gastrointestinal haemorrhage	89.48	19.13	8	400962	18844	63069208
Acute hepatic failure	89.12	19.13	7	400963	18320	63069732
Tinnitus	88.42	19.13	58	400912	35570	63052482
Erythema	87.94	19.13	699	400271	175052	62913000
General physical health deterioration	87.44	19.13	1771	399199	199631	62888421
Muscular weakness	87.35	19.13	436	400534	121917	62966135
Eye swelling	86.69	19.13	22	400948	23896	63064156
Heart rate decreased	85.31	19.13	97	400873	45463	63042589
Rheumatoid factor negative	84.52	19.13	51	400919	560	63087492
Inappropriate antidiuretic hormone secretion	84.21	19.13	3	400967	15459	63072593
Glaucoma	84.14	19.13	287	400683	18618	63069434
Small intestinal obstruction	83.83	19.13	9	400961	18328	63069724
Cyanosis	83.68	19.13	6	400964	16929	63071123
Myelosuppression	83.64	19.13	23	400947	23680	63064372
Rheumatoid lung	83.44	19.13	112	400858	3736	63084316
Ataxia	82.58	19.13	3	400967	15192	63072860
Cytomegalovirus infection	82.54	19.13	16	400954	20936	63067116
Mitral valve incompetence	81.47	19.13	13	400957	19581	63068471
Off label use	81.02	19.13	5112	395858	669350	62418702
Wheelchair user	80.71	19.13	144	400826	6175	63081877
Accidental exposure to product	80.57	19.13	36	400934	27369	63060683
Diabetic ketoacidosis	80.06	19.13	16	400954	20489	63067563
Lymphadenopathy	79.79	19.13	75	400895	38383	63049669
Throat irritation	79.79	19.13	72	400898	37575	63050477
Metastases to liver	79.64	19.13	25	400945	23614	63064438
Paraesthesia oral	79.56	19.13	13	400957	19243	63068809
Transfusion	79.40	19.13	4	400966	15213	63072839
Injection site swelling	78.96	19.13	111	400859	47461	63040591
Lymphopenia	78.87	19.13	11	400959	18316	63069736
Sinus bradycardia	78.64	19.13	3	400967	14548	63073504
Transient ischaemic attack	77.88	19.13	74	400896	37679	63050373
Bursitis	77.73	19.13	449	400521	36592	63051460
Eczema	76.89	19.13	55	400915	32236	63055816
Bronchitis chronic	75.65	19.13	114	400856	4239	63083813
Injection site pruritus	75.15	19.13	105	400865	45011	63043041
Vascular access complication	74.68	19.13	79	400891	2039	63086013
Hepatic cytolysis	74.60	19.13	6	400964	15401	63072651
Blood glucose decreased	74.55	19.13	20	400950	20932	63067120
Dislocation of vertebra	74.45	19.13	167	400803	8468	63079584
Surgical failure	74.25	19.13	56	400914	910	63087142
Joint injury	73.91	19.13	376	400594	29196	63058856
Heart rate irregular	73.27	19.13	25	400945	22396	63065656
Oropharyngeal pain	73.13	19.13	327	400643	94160	62993892
Mental impairment	72.96	19.13	4	400966	14147	63073905
Red cell distribution width decreased	72.77	19.13	77	400893	1988	63086064
Tricuspid valve incompetence	72.77	19.13	5	400965	14616	63073436
Demyelination	72.62	19.13	145	400825	6775	63081277
Right ventricular failure	72.38	19.13	11	400959	17177	63070875
Bone density decreased	72.35	19.13	230	400740	14382	63073670
Bone swelling	72.05	19.13	70	400900	1628	63086424
Productive cough	71.97	19.13	185	400785	63023	63025029
Renal impairment	71.92	19.13	300	400670	88055	62999997
Haemorrhage intracranial	71.73	19.13	3	400967	13416	63074636
Multiple sclerosis	71.68	19.13	32	400938	24340	63063712
Adjustment disorder with depressed mood	71.42	19.13	182	400788	10022	63078030
Bacteraemia	71.04	19.13	12	400958	17336	63070716
Osteonecrosis	70.91	19.13	33	400937	24497	63063555
Ageusia	70.40	19.13	4	400966	13724	63074328
Clostridium difficile infection	69.90	19.13	52	400918	29870	63058182
Body temperature increased	69.86	19.13	438	400532	36754	63051298
Hypoaesthesia oral	69.38	19.13	3	400967	13030	63075022
Breast cancer stage III	69.35	19.13	182	400788	10204	63077848
Caesarean section	69.26	19.13	12	400958	17020	63071032
Posterior reversible encephalopathy syndrome	68.85	19.13	13	400957	17332	63070720
Pancreatitis	68.71	19.13	128	400842	48927	63039125
Malnutrition	68.70	19.13	8	400962	15290	63072762
Glomerular filtration rate decreased	68.68	19.13	4	400966	13437	63074615
Disease recurrence	67.72	19.13	47	400923	27983	63060069
Unevaluable event	67.72	19.13	139	400831	51247	63036805
Retching	67.43	19.13	7	400963	14638	63073414
Blood magnesium decreased	67.21	19.13	4	400966	13194	63074858
Angina pectoris	66.81	19.13	55	400915	30023	63058029
X-ray abnormal	66.76	19.13	154	400816	7956	63080096
Premature labour	66.17	19.13	3	400967	12501	63075551
Respiratory disorder	65.93	19.13	448	400522	38634	63049418
Acute myeloid leukaemia	65.66	19.13	14	400956	17133	63070919
Systemic lupus erythematosus rash	65.60	19.13	76	400894	2176	63085876
Ulcer	65.29	19.13	332	400638	25775	63062277
Heavy menstrual bleeding	65.09	19.13	16	400954	17757	63070295
Hyperthyroidism	65.08	19.13	8	400962	14665	63073387
Exostosis	64.99	19.13	254	400716	17608	63070444
Dermatitis allergic	64.83	19.13	227	400743	14921	63073131
Mean platelet volume decreased	64.59	19.13	82	400888	2587	63085465
Spinal column injury	64.46	19.13	72	400898	1979	63086073
Hypothermia	63.82	19.13	6	400964	13575	63074477
Eye pain	63.47	19.13	72	400898	33782	63054270
Haematoma	63.19	19.13	76	400894	34744	63053308
Subdural haematoma	63.09	19.13	8	400962	14320	63073732
Left ventricular dysfunction	63.03	19.13	3	400967	11985	63076067
Dystonia	62.62	19.13	7	400963	13812	63074240
Throat tightness	62.45	19.13	40	400930	24847	63063205
Head injury	62.22	19.13	49	400921	27347	63060705
Loose body in joint	62.19	19.13	57	400913	1229	63086823
Ankle operation	62.15	19.13	57	400913	1230	63086822
Extrapyramidal disorder	62.08	19.13	6	400964	13278	63074774
Hyperlipidaemia	61.94	19.13	23	400947	19548	63068504
Rash papular	61.83	19.13	12	400958	15690	63072362
Sensory disturbance	61.77	19.13	7	400963	13665	63074387
Sinus congestion	61.35	19.13	19	400951	18104	63069948
Ventricular extrasystoles	61.21	19.13	3	400967	11684	63076368
Injection site warmth	61.15	19.13	11	400959	15184	63072868
Tuberculin test positive	61.08	19.13	92	400878	3419	63084633
Blood albumin decreased	60.94	19.13	10	400960	14756	63073296
Eye pruritus	60.70	19.13	21	400949	18650	63069402
Multiple fractures	60.61	19.13	154	400816	8464	63079588
Subarachnoid haemorrhage	60.47	19.13	9	400961	14274	63073778
Macular degeneration	60.06	19.13	40	400930	24336	63063716
Cardiac murmur	59.73	19.13	10	400960	14542	63073510
Myelodysplastic syndrome	59.60	19.13	16	400954	16738	63071314
Epilepsy	59.49	19.13	50	400920	27015	63061037
Joint dislocation	59.44	19.13	256	400714	18544	63069508
Rash macular	59.39	19.13	37	400933	23327	63064725
Hepatic encephalopathy	58.76	19.13	3	400967	11279	63076773
Colitis microscopic	58.67	19.13	160	400810	9179	63078873
Anti-cyclic citrullinated peptide antibody	58.60	19.13	131	400839	6627	63081425
Infusion site reaction	58.20	19.13	91	400879	3496	63084556
Food allergy	57.86	19.13	181	400789	11220	63076832
Pain of skin	57.84	19.13	4	400966	11630	63076422
Seasonal allergy	57.81	19.13	30	400940	20920	63067132
Ankle arthroplasty	57.59	19.13	64	400906	1749	63086303
Alanine aminotransferase increased	57.46	19.13	401	400569	103369	62984683
Blood triglycerides increased	57.42	19.13	6	400964	12482	63075570
Product label confusion	57.33	19.13	64	400906	1758	63086294
Ischaemic stroke	57.00	19.13	21	400949	17936	63070116
Hepatitis	56.70	19.13	438	400532	39350	63048702
Osteoporotic fracture	56.61	19.13	92	400878	3654	63084398
Upper-airway cough syndrome	56.55	19.13	4	400966	11414	63076638
Metastases to central nervous system	56.08	19.13	8	400962	13097	63074955
Hypoalbuminaemia	56.05	19.13	5	400965	11800	63076252
Poor quality sleep	55.82	19.13	28	400942	19907	63068145
Head discomfort	55.55	19.13	9	400961	13406	63074646
Adverse reaction	55.53	19.13	166	400804	10037	63078015
Fungal infection	55.46	19.13	92	400878	36782	63051270
Joint effusion	55.25	19.13	234	400736	16826	63071226
Myopathy	55.20	19.13	4	400966	11187	63076865
Contusion	54.74	19.13	1287	399683	148757	62939295
Mania	54.23	19.13	7	400963	12360	63075692
Eosinophil count increased	53.63	19.13	4	400966	10924	63077128
Fistula	53.39	19.13	3	400967	10390	63077662
Lacrimation increased	53.38	19.13	32	400938	20599	63067453
Infusion site pain	53.09	19.13	20	400950	16849	63071203
Seronegative arthritis	52.87	19.13	92	400878	3867	63084185
Pneumonitis	52.86	19.13	88	400882	35134	63052918
Cystitis	52.39	19.13	175	400795	54816	63033236
Intestinal obstruction	52.38	19.13	71	400899	30828	63057224
Anticipatory anxiety	52.01	19.13	51	400919	1200	63086852
Cardiomegaly	52.00	19.13	23	400947	17591	63070461
Atelectasis	51.93	19.13	36	400934	21447	63066605
Septic shock	51.91	19.13	230	400740	66399	63021653
Dysstasia	51.79	19.13	35	400935	21131	63066921
Cardiac disorder	51.71	19.13	157	400813	50659	63037393
White blood cell count increased	51.62	19.13	147	400823	48414	63039638
Blindness	51.61	19.13	37	400933	21662	63066390
Cerebral infarction	51.47	19.13	45	400925	23848	63064204
Peritonitis	51.27	19.13	22	400948	17132	63070920
Abnormal dreams	51.18	19.13	4	400966	10512	63077540
Presbyacusis	51.17	19.13	76	400894	2789	63085263
Haemorrhoids	51.09	19.13	39	400931	22111	63065941
Hypercholesterolaemia	51.05	19.13	268	400702	21066	63066986
Product administration error	50.94	19.13	40	400930	22357	63065695
Urine output decreased	50.92	19.13	6	400964	11364	63076688
Wrist surgery	50.75	19.13	43	400927	832	63087220
Mood altered	50.73	19.13	15	400955	14728	63073324
Influenza like illness	50.67	19.13	233	400737	66591	63021461
Pruritus allergic	50.52	19.13	56	400914	1526	63086526
Cardiomyopathy	50.30	19.13	24	400946	17560	63070492
Myocardial ischaemia	50.27	19.13	10	400960	12849	63075203
Nodule	50.23	19.13	264	400706	20762	63067290
Hypoacusis	50.21	19.13	47	400923	24104	63063948
Incontinence	50.01	19.13	7	400963	11625	63076427
Pneumothorax	49.99	19.13	20	400950	16241	63071811
Product quality issue	49.86	19.13	94	400876	35771	63052281
Hypovolaemia	49.41	19.13	5	400965	10668	63077384
Muscle tightness	49.24	19.13	8	400962	11892	63076160
Diabetes mellitus inadequate control	49.19	19.13	17	400953	15109	63072943
Migraine	48.94	19.13	417	400553	102929	62985123
Renal disorder	48.92	19.13	83	400887	32891	63055161
Loss of consciousness	48.87	19.13	493	400477	117628	62970424
Ileus	48.85	19.13	16	400954	14709	63073343
Peripheral coldness	48.54	19.13	9	400961	12156	63075896
Lower limb fracture	48.49	19.13	290	400680	23931	63064121
Cardiac failure acute	48.15	19.13	3	400967	9520	63078532
Metastases to lung	47.63	19.13	11	400959	12739	63075313
Mesenteritis	47.30	19.13	28	400942	296	63087756
Emotional disorder	47.17	19.13	13	400957	13366	63074686
Spinal stenosis	47.01	19.13	203	400767	14722	63073330
Hypotonia	46.73	19.13	3	400967	9282	63078770
Thinking abnormal	46.72	19.13	6	400964	10637	63077415
Central nervous system lesion	46.68	19.13	6	400964	10629	63077423
Supraventricular tachycardia	46.48	19.13	16	400954	14255	63073797
Faeces discoloured	46.10	19.13	30	400940	18479	63069573
Polyarthritis	46.00	19.13	155	400815	9991	63078061
Arteriosclerosis	45.86	19.13	5	400965	10061	63077991
Liver disorder	45.85	19.13	530	400440	53157	63034895
Micturition urgency	45.83	19.13	4	400966	9607	63078445
Eyelid oedema	45.78	19.13	6	400964	10473	63077579
Lung infiltration	45.77	19.13	17	400953	14446	63073606
Concomitant disease aggravated	45.69	19.13	3	400967	9109	63078943
Oliguria	45.62	19.13	3	400967	9098	63078954
Eye irritation	45.40	19.13	43	400927	21928	63066124
Oesophagitis	45.26	19.13	19	400951	14989	63073063
Schizophrenia	45.20	19.13	5	400965	9947	63078105
Back pain	45.19	19.13	1296	399674	262849	62825203
Leukopenia	45.12	19.13	294	400676	76996	63011056
Device breakage	45.07	19.13	9	400961	11533	63076519
Splenomegaly	45.06	19.13	8	400962	11149	63076903
Therapeutic response shortened	44.93	19.13	10	400960	11878	63076174
Vitamin D deficiency	44.52	19.13	16	400954	13876	63074176
Hyperaesthesia	44.33	19.13	4	400966	9354	63078698
Blood calcium increased	44.29	19.13	4	400966	9346	63078706
Drug specific antibody	44.27	19.13	64	400906	2291	63085761
Purpura	44.21	19.13	9	400961	11376	63076676
Atrial flutter	44.15	19.13	5	400965	9767	63078285
Limb operation	44.15	19.13	86	400884	3945	63084107
Hemiplegia	44.13	19.13	4	400966	9319	63078733
Injection site mass	44.12	19.13	32	400938	18624	63069428
Erythema multiforme	44.00	19.13	6	400964	10163	63077889
Sebaceous gland infection	43.98	19.13	22	400948	161	63087891
Obesity	43.95	19.13	332	400638	29620	63058432
Acute coronary syndrome	43.76	19.13	6	400964	10120	63077932
Troponin increased	43.73	19.13	6	400964	10115	63077937
Joint arthroplasty	43.73	19.13	69	400901	2672	63085380
Foot operation	43.56	19.13	122	400848	7109	63080943
Rales	43.54	19.13	13	400957	12684	63075368
Sneezing	43.41	19.13	31	400939	18187	63069865
Ocular hyperaemia	43.41	19.13	57	400913	25087	63062965
Peptic ulcer haemorrhage	43.40	19.13	43	400927	1025	63087027
Increased appetite	43.33	19.13	5	400965	9625	63078427
Sudden death	43.29	19.13	7	400963	10442	63077610
Dialysis	43.17	19.13	7	400963	10420	63077632
Asthma	43.14	19.13	557	400413	127004	62961048
Incorrect product administration duration	43.06	19.13	10	400960	11536	63076516
Hepatomegaly	42.96	19.13	11	400959	11878	63076174
Therapy non-responder	42.96	19.13	696	400274	75205	63012847
Blood pressure diastolic decreased	42.88	19.13	48	400922	22658	63065394
Haematocrit decreased	42.62	19.13	118	400852	39222	63048830
Amenorrhoea	42.55	19.13	6	400964	9908	63078144
Cholecystitis	42.46	19.13	22	400948	15355	63072697
Shock haemorrhagic	42.44	19.13	6	400964	9889	63078163
Polyuria	42.28	19.13	3	400967	8539	63079513
Impaired work ability	42.14	19.13	220	400750	17255	63070797
Haemophagocytic lymphohistiocytosis	42.10	19.13	8	400962	10619	63077433
Pleural fibrosis	41.65	19.13	77	400893	3395	63084657
Deep vein thrombosis postoperative	41.63	19.13	162	400808	11207	63076845
Blood iron abnormal	41.61	19.13	82	400888	3794	63084258
Back injury	41.55	19.13	145	400825	9515	63078537
Drug use disorder	41.42	19.13	95	400875	4889	63083163
Blood pressure diastolic abnormal	41.36	19.13	20	400950	14522	63073530
Mean cell volume decreased	41.32	19.13	83	400887	3895	63084157
Transaminases abnormal	41.26	19.13	34	400936	632	63087420
Bedridden	40.90	19.13	158	400812	10893	63077159
Transplant rejection	40.88	19.13	9	400961	10771	63077281
Motor dysfunction	40.77	19.13	9	400961	10752	63077300
Onychomadesis	40.70	19.13	104	400866	5736	63082316
Drug resistance	40.61	19.13	51	400919	22882	63065170
Pre-existing condition improved	40.51	19.13	3	400967	8241	63079811
Pre-eclampsia	40.46	19.13	5	400965	9128	63078924
Toothache	40.34	19.13	37	400933	19162	63068890
Cold sweat	40.12	19.13	13	400957	12034	63076018
Infusion site erythema	39.97	19.13	12	400958	11667	63076385
Sensory loss	39.95	19.13	8	400962	10230	63077822
Facet joint syndrome	39.70	19.13	167	400803	11971	63076081
Cytopenia	39.56	19.13	12	400958	11589	63076463
Dermatitis bullous	39.35	19.13	4	400966	8504	63079548
Live birth	39.25	19.13	287	400683	25343	63062709
Dermatitis atopic	39.21	19.13	7	400963	9717	63078335
Sinus disorder	39.07	19.13	59	400911	24494	63063558
Retinitis	38.77	19.13	106	400864	6090	63081962
Sputum discoloured	38.71	19.13	28	400942	16319	63071733
Soft tissue disorder	38.66	19.13	86	400884	4336	63083716
Pleural thickening	38.50	19.13	67	400903	2816	63085236
Vaginal discharge	38.47	19.13	6	400964	9192	63078860
Hypocalcaemia	38.31	19.13	90	400880	31623	63056429
Musculoskeletal chest pain	38.27	19.13	46	400924	21037	63067015
Breast cancer metastatic	38.24	19.13	14	400956	12004	63076048
Lip dry	38.17	19.13	196	400774	15274	63072778
Nail disorder	37.95	19.13	173	400797	12842	63075210
Aspartate aminotransferase increased	37.67	19.13	376	400594	89901	62998151
Enthesopathy	37.66	19.13	130	400840	8484	63079568
Pseudomonas infection	37.52	19.13	12	400958	11201	63076851
Wheezing	37.49	19.13	404	400566	95191	62992861
Bunion operation	37.48	19.13	44	400926	1278	63086774
Facial paralysis	37.43	19.13	21	400949	14020	63074032
Dementia	37.42	19.13	38	400932	18756	63069296
Infusion site swelling	37.36	19.13	8	400962	9762	63078290
Blood loss anaemia	37.36	19.13	6	400964	8995	63079057
Metastases to lymph nodes	37.30	19.13	4	400966	8154	63079898
Skin disorder	37.05	19.13	82	400888	29425	63058627
Acne	37.03	19.13	56	400914	23237	63064815
Glycosylated haemoglobin increased	36.90	19.13	16	400954	12382	63075670
Blood test abnormal	36.71	19.13	27	400943	15602	63072450
Pain assessment	36.64	19.13	9	400961	0	63088052
Product use in unapproved indication	36.62	19.13	856	400114	178224	62909828
Dermatitis contact	36.45	19.13	12	400958	10996	63077056
Injection site induration	36.44	19.13	7	400963	9219	63078833
Therapy partial responder	36.39	19.13	11	400959	10647	63077405
Gestational diabetes	36.22	19.13	5	400965	8391	63079661
Mood swings	36.22	19.13	37	400933	18211	63069841
Second primary malignancy	36.11	19.13	4	400966	7949	63080103
Arteriosclerosis coronary artery	36.09	19.13	5	400965	8368	63079684
Mean cell haemoglobin decreased	35.86	19.13	92	400878	5087	63082965
Sleep disorder due to a general medical condition	35.85	19.13	16	400954	12172	63075880
Peripheral sensory neuropathy	35.80	19.13	3	400967	7448	63080604
Stress cardiomyopathy	35.61	19.13	8	400962	9442	63078610
Ovarian cyst	35.61	19.13	29	400941	15916	63072136
Escherichia infection	35.58	19.13	18	400952	12736	63075316
Device safety feature issue	35.45	19.13	10	400960	7	63088045
Device occlusion	35.42	19.13	3	400967	7384	63080668
Dizziness postural	35.36	19.13	3	400967	7373	63080679
Petechiae	35.33	19.13	22	400948	13875	63074177
Bronchopulmonary aspergillosis	35.30	19.13	6	400964	8629	63079423
Rhinitis allergic	35.11	19.13	15	400955	11712	63076340
Hypercalcaemia	35.07	19.13	302	400668	28020	63060032
Eating disorder	35.04	19.13	41	400929	18975	63069077
Middle insomnia	35.04	19.13	18	400952	12625	63075427
Thyroid neoplasm	34.95	19.13	78	400892	3941	63084111
Product temperature excursion issue	34.90	19.13	20	400950	198	63087854
Transaminases increased	34.79	19.13	93	400877	31274	63056778
Blood magnesium increased	34.73	19.13	66	400904	2972	63085080
Neutrophil count increased	34.55	19.13	32	400938	16495	63071557
Hypernatraemia	34.11	19.13	4	400966	7605	63080447
Infiltration anaesthesia	34.04	19.13	19	400951	178	63087874
Hyperthermia	34.01	19.13	8	400962	9148	63078904
Foetal growth restriction	33.79	19.13	4	400966	7549	63080503
Device leakage	33.59	19.13	110	400860	6986	63081066
Injection site haemorrhage	33.56	19.13	64	400906	24250	63063802
Wound infection	33.51	19.13	241	400729	21169	63066883
Rib fracture	33.41	19.13	57	400913	22540	63065512
Blood pressure systolic abnormal	32.93	19.13	22	400948	13364	63074688
Atrial septal defect	32.78	19.13	3	400967	6935	63081117
Acute pulmonary oedema	32.62	19.13	6	400964	8152	63079900
Breast cancer stage I	32.49	19.13	3	400967	6886	63081166
Thrombotic microangiopathy	32.44	19.13	13	400957	10548	63077504
Eyelid ptosis	32.14	19.13	4	400966	7263	63080789
Injection site rash	32.10	19.13	43	400927	18766	63069286
Atrioventricular block	31.96	19.13	5	400965	7642	63080410
Skin fissures	31.88	19.13	16	400954	11372	63076680
Shoulder arthroplasty	31.85	19.13	75	400895	3927	63084125
Cutaneous vasculitis	31.84	19.13	89	400881	5180	63082872
Chronic sinusitis	31.74	19.13	21	400949	12822	63075230
Cerebral ischaemia	31.54	19.13	3	400967	6725	63081327
Respiratory rate increased	31.51	19.13	24	400946	13624	63074428
Hereditary angioedema	31.48	19.13	5	400965	7557	63080495
Respiratory acidosis	31.47	19.13	3	400967	6712	63081340
Impaired gastric emptying	31.37	19.13	139	400831	10193	63077859
Stress	31.35	19.13	272	400698	66895	63021157
Intermenstrual bleeding	31.33	19.13	6	400964	7920	63080132
Fear	31.25	19.13	32	400938	15734	63072318
Enteritis	31.25	19.13	7	400963	8279	63079773
Injection site bruising	31.25	19.13	147	400823	41763	63046289
Myocarditis	31.25	19.13	13	400957	10312	63077740
Blood glucose abnormal	31.14	19.13	6	400964	7886	63080166
Lower gastrointestinal haemorrhage	31.13	19.13	6	400964	7884	63080168
Renal cyst	31.13	19.13	13	400957	10289	63077763
Nerve injury	31.11	19.13	135	400835	9811	63078241
Progressive multifocal leukoencephalopathy	31.00	19.13	22	400948	12949	63075103
Facial pain	30.85	19.13	14	400956	10547	63077505
Accident	30.83	19.13	96	400874	5936	63082116
Deafness	30.70	19.13	41	400929	17916	63070136
White blood cell count abnormal	30.67	19.13	98	400872	6144	63081908
Scratch	30.59	19.13	3	400967	6562	63081490
Duodenal ulcer	30.39	19.13	6	400964	7750	63080302
Large intestine perforation	30.36	19.13	8	400962	8474	63079578
Taste disorder	30.32	19.13	25	400945	13637	63074415
Hypokinesia	30.31	19.13	26	400944	13910	63074142
Body temperature decreased	30.27	19.13	51	400919	20268	63067784
Lupus vulgaris	30.27	19.13	95	400875	5899	63082153
Colitis ulcerative	29.98	19.13	76	400894	26015	63062037
Pharyngitis streptococcal	29.86	19.13	15	400955	10657	63077395
Skin reaction	29.86	19.13	178	400792	14671	63073381
Vasculitic rash	29.58	19.13	40	400930	1344	63086708
Procedural pain	29.57	19.13	57	400913	21512	63066540
Surgery	29.54	19.13	352	400618	35560	63052492
Post procedural haemorrhage	29.50	19.13	7	400963	7957	63080095
Failure to thrive	29.43	19.13	5	400965	7193	63080859
Muscle strain	29.24	19.13	8	400962	8266	63079786
Cholecystitis acute	29.17	19.13	8	400962	8252	63079800
Stillbirth	29.17	19.13	4	400966	6746	63081306
Pulseless electrical activity	29.09	19.13	6	400964	7515	63080537
COVID-19	28.95	19.13	521	400449	112582	62975470
Peripheral venous disease	28.89	19.13	182	400788	15295	63072757
Coronary artery occlusion	28.80	19.13	8	400962	8183	63079869
Drug tolerance	28.76	19.13	103	400867	6846	63081206
Skin haemorrhage	28.53	19.13	14	400956	10080	63077972
Loss of employment	28.48	19.13	51	400919	2193	63085859
Polyneuropathy	28.48	19.13	30	400940	14559	63073493
Congestive cardiomyopathy	28.35	19.13	3	400967	6179	63081873
Restless legs syndrome	28.08	19.13	46	400924	18485	63069567
Sensitivity to weather change	28.04	19.13	105	400865	7132	63080920
Rash maculo-papular	28.04	19.13	105	400865	31791	63056261
Red blood cell count decreased	27.77	19.13	147	400823	40498	63047554
Product complaint	27.74	19.13	24	400946	12785	63075267
Intestinal perforation	27.67	19.13	21	400949	11942	63076110
Delirium	27.63	19.13	196	400774	50345	63037707
Skin neoplasm excision	27.37	19.13	29	400941	750	63087302
Respiration abnormal	27.27	19.13	4	400966	6413	63081639
Bacterial infection	27.20	19.13	51	400919	19448	63068604
Skin papilloma	27.19	19.13	81	400889	4888	63083164
Neuralgia	27.17	19.13	79	400891	25847	63062205
Limb injury	27.16	19.13	77	400893	25400	63062652
Pathogen resistance	27.16	19.13	4	400966	6394	63081658
Gastric haemorrhage	27.16	19.13	4	400966	6394	63081658
Hypertensive crisis	27.06	19.13	34	400936	15252	63072800
Enterocolitis	27.03	19.13	8	400962	7850	63080202
Synovial cyst	27.02	19.13	134	400836	10299	63077753
Graft versus host disease	26.99	19.13	5	400965	6758	63081294
Hydronephrosis	26.94	19.13	17	400953	10645	63077407
Low birth weight baby	26.93	19.13	6	400964	7123	63080929
Ovarian neoplasm	26.91	19.13	31	400939	882	63087170
Extra dose administered	26.89	19.13	4	400966	6346	63081706
Gingival pain	26.84	19.13	9	400961	8153	63079899
Skin irritation	26.80	19.13	14	400956	9727	63078325
Investigation abnormal	26.80	19.13	46	400924	1912	63086140
Hepatitis acute	26.78	19.13	12	400958	9108	63078944
Device issue	26.76	19.13	70	400900	23711	63064341
Diverticulitis	26.75	19.13	374	400596	39183	63048869
Metabolic encephalopathy	26.18	19.13	3	400967	5806	63082246
Impaired quality of life	26.18	19.13	29	400941	13754	63074298
Alanine aminotransferase abnormal	26.16	19.13	75	400895	4429	63083623
Mouth ulceration	26.13	19.13	321	400649	32663	63055389
Major depression	26.09	19.13	9	400961	8009	63080043
Personality change	26.08	19.13	6	400964	6967	63081085
Intestinal sepsis	26.03	19.13	19	400951	293	63087759
Appetite disorder	26.02	19.13	7	400963	7314	63080738
Choking	26.01	19.13	15	400955	9864	63078188
Needle issue	25.97	19.13	132	400838	10244	63077808
Maternal exposure timing unspecified	25.96	19.13	101	400869	6986	63081066
Device use error	25.90	19.13	3	400967	5758	63082294
Walking aid user	25.90	19.13	135	400835	10582	63077470
Bone cyst	25.81	19.13	49	400921	2205	63085847
Cachexia	25.70	19.13	3	400967	5723	63082329
Faecaloma	25.69	19.13	9	400961	7932	63080120
Cartilage atrophy	25.55	19.13	15	400955	156	63087896
Metabolic disorder	25.54	19.13	5	400965	6498	63081554
Hiatus hernia	25.51	19.13	62	400908	21532	63066520
Deafness neurosensory	25.49	19.13	78	400892	4777	63083275
Allergy to chemicals	25.30	19.13	58	400912	2984	63085068
Breast pain	25.18	19.13	12	400958	8786	63079266
Blood urine present	25.16	19.13	35	400935	15034	63073018
Systemic inflammatory response syndrome	25.09	19.13	3	400967	5618	63082434
Pelvic pain	25.07	19.13	29	400941	13490	63074562
Ecchymosis	24.99	19.13	20	400950	11074	63076978
Vitreous floaters	24.71	19.13	4	400966	5962	63082090
Muscle atrophy	24.49	19.13	7	400963	7026	63081026
Ankle deformity	24.48	19.13	22	400948	462	63087590
Lupus-like syndrome	24.42	19.13	173	400797	15122	63072930
Pemphigoid	24.32	19.13	8	400962	7336	63080716
Dry mouth	24.15	19.13	346	400624	77517	63010535
Herpes simplex	24.10	19.13	11	400959	8260	63079792
Blindness unilateral	24.09	19.13	5	400965	6236	63081816
Antibody test positive	24.06	19.13	53	400917	2654	63085398
Overlap syndrome	24.05	19.13	29	400941	867	63087185
Product dose omission in error	24.00	19.13	9	400961	7603	63080449
No adverse event	23.91	19.13	158	400812	41247	63046805
Visual field defect	23.84	19.13	6	400964	6555	63081497
Haemorrhagic stroke	23.73	19.13	4	400966	5788	63082264
Flank pain	23.71	19.13	42	400928	16368	63071684
Injury	23.62	19.13	618	400352	72629	63015423
Dental caries	23.58	19.13	20	400950	10759	63077293
Tooth loss	23.55	19.13	7	400963	6849	63081203
Endocarditis	23.49	19.13	4	400966	5746	63082306
Feeding disorder	23.37	19.13	30	400940	13332	63074720
Diastolic dysfunction	23.36	19.13	6	400964	6465	63081587
Pruritus	23.36	19.13	2616	398354	358837	62729215
Left ventricular hypertrophy	23.32	19.13	3	400967	5312	63082740
Colitis ischaemic	23.26	19.13	20	400950	10688	63077364
Viral infection	23.25	19.13	131	400839	35532	63052520
Skin laceration	23.21	19.13	70	400900	22638	63065414
Therapy change	23.21	19.13	5	400965	6076	63081976
Weight fluctuation	23.02	19.13	17	400953	9802	63078250
Concussion	23.00	19.13	15	400955	9229	63078823
Gout	23.00	19.13	30	400940	13241	63074811
Nasal polyps	22.98	19.13	5	400965	6034	63082018
Infusion site pruritus	22.96	19.13	5	400965	6030	63082022
Psychiatric symptom	22.80	19.13	3	400967	5220	63082832
Blood pressure abnormal	22.78	19.13	38	400932	15160	63072892
Viral upper respiratory tract infection	22.77	19.13	103	400867	7621	63080431
Metastasis	22.65	19.13	3	400967	5194	63082858
Proteinuria	22.59	19.13	55	400915	19090	63068962
Decreased activity	22.55	19.13	6	400964	6314	63081738
Bronchospasm	22.54	19.13	47	400923	17233	63070819
Multiple-drug resistance	22.49	19.13	3	400967	5167	63082885
Paronychia	22.46	19.13	4	400966	5561	63082491
Fluid retention	22.30	19.13	255	400715	59431	63028621
Autoimmune hepatitis	22.30	19.13	13	400957	8497	63079555
Hypovolaemic shock	22.12	19.13	6	400964	6235	63081817
Diarrhoea haemorrhagic	22.06	19.13	15	400955	9027	63079025
Immobile	22.02	19.13	85	400885	5858	63082194
Influenza	21.85	19.13	521	400449	108201	62979851
Anger	21.75	19.13	28	400942	12428	63075624
Intestinal ischaemia	21.66	19.13	10	400960	7458	63080594
Feeling jittery	21.52	19.13	32	400938	13371	63074681
Normal newborn	21.49	19.13	13	400957	8328	63079724
Eructation	21.45	19.13	13	400957	8320	63079732
Immune thrombocytopenia	21.41	19.13	21	400949	10535	63077517
Extremity contracture	21.41	19.13	33	400937	1252	63086800
Skin plaque	21.39	19.13	13	400957	8307	63079745
Atypical femur fracture	21.38	19.13	4	400966	5368	63082684
Laryngeal oedema	21.23	19.13	5	400965	5713	63082339
Pathological fracture	21.09	19.13	15	400955	8819	63079233
Catheter site infection	21.03	19.13	3	400967	4911	63083141
Peripheral vascular disorder	21.02	19.13	6	400964	6029	63082023
Amnesia	20.96	19.13	237	400733	55348	63032704
Feeling of body temperature change	20.93	19.13	3	400967	4894	63083158
COVID-19 pneumonia	20.86	19.13	36	400934	14173	63073879
Cytomegalovirus viraemia	20.85	19.13	5	400965	5644	63082408
Nephropathy	20.84	19.13	7	400963	6334	63081718
Aortic valve incompetence	20.77	19.13	6	400964	5982	63082070
Protein total decreased	20.71	19.13	6	400964	5971	63082081
Rheumatic disorder	20.68	19.13	54	400916	3018	63085034
Hypertransaminasaemia	20.53	19.13	8	400962	6601	63081451
Iron deficiency	20.48	19.13	10	400960	7220	63080832
Skin hyperpigmentation	20.42	19.13	6	400964	5915	63082137
Aspergillus infection	20.32	19.13	13	400957	8080	63079972
Extrasystoles	20.20	19.13	4	400966	5156	63082896
Fracture treatment	20.17	19.13	11	400959	98	63087954
Hepatic cyst	20.17	19.13	4	400966	5150	63082902
Device difficult to use	20.11	19.13	31	400939	12765	63075287
Mouth swelling	20.04	19.13	3	400967	4737	63083315
Expired product administered	20.01	19.13	7	400963	6174	63081878
Hip fracture	19.91	19.13	107	400863	29367	63058685
Wrong product administered	19.80	19.13	7	400963	6134	63081918
Infusion site haemorrhage	19.79	19.13	4	400966	5082	63082970
Pregnancy with contraceptive device	19.77	19.13	3	400967	4691	63083361
Photophobia	19.77	19.13	52	400918	17583	63070469
Escherichia urinary tract infection	19.76	19.13	28	400942	11934	63076118
Cerebral atrophy	19.68	19.13	4	400966	5062	63082990
Pulmonary alveolar haemorrhage	19.63	19.13	3	400967	4665	63083387
Abscess	19.58	19.13	48	400922	16620	63071432
Amyotrophic lateral sclerosis	19.56	19.13	30	400940	1133	63086919
Brain injury	19.56	19.13	10	400960	7033	63081019
Fibrin D dimer increased	19.50	19.13	4	400966	5030	63083022
Injection site urticaria	19.46	19.13	37	400933	14036	63074016
Nail operation	19.44	19.13	26	400944	864	63087188
Respiratory syncytial virus infection	19.44	19.13	10	400960	7008	63081044
Injection site discomfort	19.41	19.13	3	400967	4627	63083425
Hypoaesthesia	19.23	19.13	868	400102	167525	62920527
Oral pain	19.22	19.13	103	400867	28291	63059761
Papule	19.20	19.13	6	400964	5685	63082367
Injection site irritation	19.19	19.13	4	400966	4974	63083078
Left ventricular failure	19.18	19.13	6	400964	5681	63082371
Increased tendency to bruise	19.18	19.13	23	400947	10529	63077523
Retinal haemorrhage	19.14	19.13	4	400966	4965	63083087

FDA Adverse Event Reporting System (Male)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Drug ineffective	2200.16	23.76	2675	38692	454076	34461488
Joint swelling	1975.34	23.76	1091	40276	58799	34856765
Contraindicated product administered	1688.58	23.76	711	40656	20770	34894794
Synovitis	1099.15	23.76	464	40903	13602	34901962
Drug intolerance	1024.04	23.76	718	40649	58852	34856712
Rheumatoid arthritis	884.67	23.76	555	40812	37683	34877881
Treatment failure	832.74	23.76	576	40791	46121	34869443
Arthropathy	738.79	23.76	436	40931	26471	34889093
Arthralgia	730.96	23.76	949	40418	169092	34746472
C-reactive protein abnormal	678.98	23.76	287	41080	8423	34907141
Apparent death	677.63	23.76	227	41140	3417	34912147
Pain	582.89	23.76	940	40427	203735	34711829
Bone erosion	534.54	23.76	195	41172	3820	34911744
Drug hypersensitivity	529.66	23.76	560	40807	79969	34835595
Therapeutic product effect decreased	489.79	23.76	372	40995	34371	34881193
Diverticulitis	471.23	23.76	294	41073	19710	34895854
Red blood cell sedimentation rate abnormal	364.36	23.76	143	41224	3446	34912118
Loss of personal independence in daily activities	352.18	23.76	301	41066	32878	34882686
Musculoskeletal stiffness	307.07	23.76	325	41042	46355	34869209
Mobility decreased	279.00	23.76	253	41114	29875	34885689
Drug interaction	251.76	23.76	3	41364	225943	34689621
Hand deformity	251.64	23.76	111	41256	3614	34911950
Acute kidney injury	240.91	23.76	37	41330	304951	34610613
Osteoarthritis	230.70	23.76	193	41174	20449	34895115
Knee arthroplasty	228.92	23.76	130	41237	7314	34908250
Red blood cell sedimentation rate increased	226.64	23.76	139	41228	9023	34906541
Pulmonary thrombosis	218.78	23.76	126	41241	7281	34908283
Rheumatoid factor negative	211.68	23.76	67	41300	832	34914732
Toxicity to various agents	202.63	23.76	8	41359	200354	34715210
Tenosynovitis	191.43	23.76	98	41269	4472	34911092
Peripheral swelling	190.53	23.76	332	41035	76209	34839355
Herpes zoster	187.23	23.76	217	41150	34182	34881382
Drug tolerance decreased	184.37	23.76	74	41293	1893	34913671
Hypotension	179.21	23.76	25	41342	221624	34693940
C-reactive protein increased	178.82	23.76	267	41100	53831	34861733
Disability	176.21	23.76	94	41273	4671	34910893
Terminal state	175.40	23.76	88	41279	3846	34911718
Chondropathy	174.63	23.76	59	41308	911	34914653
Impaired work ability	171.04	23.76	105	41262	6825	34908739
Onychoclasis	166.13	23.76	68	41299	1832	34913732
Device malfunction	165.51	23.76	120	41247	10301	34905263
Alanine aminotransferase abnormal	158.10	23.76	87	41280	4601	34910963
Lymphoma	154.52	23.76	124	41243	12383	34903181
Arthritis	152.87	23.76	187	41180	31159	34884405
Enthesopathy	148.42	23.76	83	41284	4530	34911034
Atlantoaxial instability	143.82	23.76	40	41327	305	34915259
Febrile neutropenia	143.44	23.76	4	41363	136845	34778719
Spinal instability	141.59	23.76	40	41327	325	34915239
Mineral metabolism disorder	140.83	23.76	40	41327	332	34915232
Limb discomfort	139.62	23.76	111	41256	10936	34904628
Dislocation of vertebra	138.83	23.76	41	41326	396	34915168
Deep vein thrombosis	134.51	23.76	261	41106	64987	34850577
Drug specific antibody present	133.41	23.76	69	41298	3216	34912348
Acne cystic	132.27	23.76	41	41326	473	34915091
Tongue disorder	132.02	23.76	81	41286	5258	34910306
Sarcoidosis	129.92	23.76	65	41302	2823	34912741
Anaemia	126.64	23.76	59	41308	233276	34682288
Tooth loss	125.72	23.76	70	41297	3788	34911776
Pyrexia	118.54	23.76	132	41235	332881	34582683
Localised infection	116.47	23.76	123	41244	17464	34898100
Gastric disorder	116.10	23.76	105	41262	12336	34903228
Rheumatoid factor positive	115.77	23.76	40	41327	663	34914901
Joint arthroplasty	113.83	23.76	42	41325	849	34914715
Gait inability	111.31	23.76	130	41237	20628	34894936
Vomiting	109.72	23.76	80	41287	247541	34668023
Musculoskeletal pain	107.32	23.76	159	41208	31804	34883760
Thrombocytopenia	106.25	23.76	27	41340	156220	34759344
Skin ulcer	102.61	23.76	129	41238	22087	34893477
Abdominal pain	102.54	23.76	33	41334	163585	34751979
Intestinal sepsis	102.12	23.76	36	41331	635	34914929
Diarrhoea	101.95	23.76	192	41175	389720	34525844
Intervertebral disc space narrowing	99.95	23.76	40	41327	1015	34914549
Infection	96.73	23.76	281	41086	90634	34824930
Swelling	96.60	23.76	177	41190	42189	34873375
Tooth fracture	96.49	23.76	58	41309	3627	34911937
Confusional state	95.94	23.76	26	41341	144134	34771430
Osteosclerosis	94.43	23.76	41	41326	1283	34914281
Adverse event	94.25	23.76	114	41253	18763	34896801
Dehydration	93.22	23.76	20	41347	129949	34785615
Decreased appetite	91.86	23.76	41	41326	166351	34749213
Intestinal polyp	90.38	23.76	37	41330	997	34914567
Pulmonary embolism	90.34	23.76	272	41095	89474	34826090
Photosensitivity reaction	88.38	23.76	84	41283	10510	34905054
Drug use disorder	87.17	23.76	57	41310	4134	34911430
X-ray abnormal	85.57	23.76	29	41338	452	34915112
Urticaria	84.66	23.76	211	41156	62166	34853398
Interstitial lung disease	83.58	23.76	216	41151	65066	34850498
Sleep disorder due to general medical condition, insomnia type	81.79	23.76	37	41330	1279	34914285
Alopecia	81.52	23.76	121	41246	24234	34891330
Dyspnoea	81.51	23.76	206	41161	376576	34538988
Malignant neoplasm progression	81.18	23.76	6	41361	88040	34827524
Product storage error	80.64	23.76	71	41296	8051	34907513
Disease progression	78.79	23.76	16	41351	108061	34807503
Ill-defined disorder	77.73	23.76	89	41278	13820	34901744
Tendonitis	75.35	23.76	72	41295	9068	34906496
Hyponatraemia	75.21	23.76	6	41361	82685	34832879
Gastrointestinal disorder	75.08	23.76	140	41227	33808	34881756
Skin laceration	74.95	23.76	83	41284	12426	34903138
Pain in extremity	74.67	23.76	322	41045	126191	34789373
Polyarthritis	73.72	23.76	53	41314	4487	34911077
Blood creatinine increased	73.67	23.76	12	41355	94964	34820600
Physical disability	73.46	23.76	35	41332	1364	34914200
Seizure	73.43	23.76	17	41350	104840	34810724
Intentional product use issue	72.56	23.76	194	41173	59622	34855942
C-reactive protein decreased	69.84	23.76	38	41329	1964	34913600
Hyperkalaemia	69.26	23.76	3	41364	69386	34846178
Rhabdomyolysis	67.86	23.76	3	41364	68160	34847404
Overdose	67.37	23.76	13	41354	91046	34824518
Somnolence	66.81	23.76	24	41343	111092	34804472
Constipation	64.92	23.76	41	41326	136941	34778623
Renal impairment	64.84	23.76	16	41351	94497	34821067
Joint lock	64.22	23.76	31	41336	1244	34914320
Rheumatoid nodule	63.55	23.76	41	41326	2906	34912658
Therapeutic product effect incomplete	63.40	23.76	166	41201	50375	34865189
Hepatitis B virus test positive	63.27	23.76	21	41346	306	34915258
Tachycardia	62.93	23.76	12	41355	84760	34830804
Cardiac arrest	60.89	23.76	19	41348	96140	34819424
Seronegative arthritis	60.75	23.76	28	41339	1011	34914553
Musculoskeletal discomfort	59.86	23.76	60	41307	8008	34907556
Anxiety	58.88	23.76	22	41345	99406	34816158
Fracture	58.45	23.76	55	41312	6794	34908770
Dizziness	58.34	23.76	106	41261	218415	34697149
Neoplasm malignant	58.33	23.76	93	41274	19812	34895752
Joint range of motion decreased	57.26	23.76	56	41311	7256	34908308
Gastrointestinal haemorrhage	56.89	23.76	17	41350	88460	34827104
Joint stiffness	56.46	23.76	67	41300	10806	34904758
Bradycardia	55.29	23.76	11	41356	75407	34840157
Joint ankylosis	55.28	23.76	30	41337	1542	34914022
Hepatic cirrhosis	55.06	23.76	84	41283	17230	34898334
Bone cyst	54.79	23.76	30	41337	1570	34913994
Immobile	54.52	23.76	35	41332	2459	34913105
Inflammation	54.39	23.76	110	41257	28185	34887379
Fine motor skill dysfunction	54.12	23.76	31	41336	1771	34913793
Cardio-respiratory arrest	53.21	23.76	3	41364	55270	34860294
Pancytopenia	53.17	23.76	23	41344	95134	34820430
Thrombosis	52.68	23.76	155	41212	50303	34865261
Device defective	52.29	23.76	23	41344	743	34914821
Red blood cell sedimentation rate	51.27	23.76	26	41341	1162	34914402
Oral surgery	51.22	23.76	21	41346	568	34914996
Platelet count decreased	51.21	23.76	40	41327	119677	34795887
Anti-cyclic citrullinated peptide antibody positive	50.83	23.76	30	41337	1813	34913751
Blood glucose increased	50.47	23.76	9	41358	66709	34848855
Agitation	49.93	23.76	5	41362	57394	34858170
Hypoglycaemia	49.57	23.76	4	41363	54636	34860928
Granuloma skin	49.46	23.76	26	41341	1253	34914311
Fatigue	49.08	23.76	249	41118	370404	34545160
Surgery	48.32	23.76	71	41296	14086	34901478
Nephrolithiasis	48.03	23.76	109	41258	30224	34885340
Rheumatoid lung	47.74	23.76	23	41344	919	34914645
Liver function test increased	46.79	23.76	71	41296	14494	34901070
Neuropathy peripheral	46.71	23.76	20	41347	83243	34832321
Stent placement	45.69	23.76	42	41325	5036	34910528
International normalised ratio increased	44.26	23.76	3	41364	47324	34868240
Panniculitis	43.63	23.76	28	41339	1966	34913598
Vitamin D deficiency	43.35	23.76	46	41321	6562	34909002
Diabetes mellitus	43.33	23.76	138	41229	46735	34868829
Blood parathyroid hormone decreased	43.22	23.76	25	41342	1455	34914109
Intentional product misuse	42.34	23.76	3	41364	45608	34869956
Headache	42.27	23.76	392	40975	200243	34715321
Skin mass	41.90	23.76	36	41331	3949	34911615
Respiratory failure	41.90	23.76	40	41327	108532	34807032
Skin cancer	41.62	23.76	56	41311	10241	34905323
Loss of consciousness	41.60	23.76	23	41344	82644	34832920
Food intolerance	41.28	23.76	24	41343	1410	34914154
Renal failure	41.18	23.76	280	41087	130277	34785287
Syncope	41.11	23.76	29	41338	91422	34824142
Oral disorder	39.91	23.76	36	41331	4213	34911351
Gastrointestinal infection	39.17	23.76	41	41326	5757	34909807
Soft tissue swelling	38.94	23.76	17	41350	539	34915025
Therapy interrupted	38.76	23.76	63	41304	13634	34901930
Osteolysis	38.42	23.76	31	41336	3117	34912447
Abdominal distension	38.03	23.76	11	41356	58481	34857083
Upper respiratory tract infection	37.84	23.76	105	41262	32954	34882610
Lymphoedema	37.76	23.76	34	41333	3969	34911595
Tooth disorder	36.31	23.76	54	41313	10828	34904736
Ascites	35.83	23.76	6	41361	46565	34868999
Malignant melanoma	35.79	23.76	46	41321	8044	34907520
Hepatic function abnormal	35.77	23.76	5	41362	44358	34871206
Plasma cell myeloma	35.69	23.76	4	41363	42033	34873531
Pneumonia aspiration	35.54	23.76	4	41363	41899	34873665
Delirium	35.37	23.76	5	41362	43986	34871578
Nodule	35.37	23.76	42	41325	6777	34908787
Erythema	35.23	23.76	202	41165	88578	34826986
Abdominal discomfort	35.00	23.76	152	41215	59683	34855881
Skin injury	34.96	23.76	26	41341	2319	34913245
Tooth extraction	34.78	23.76	35	41332	4693	34910871
Blood pressure decreased	34.78	23.76	9	41358	51506	34864058
Foot deformity	34.13	23.76	34	41333	4503	34911061
Neutropenia	33.53	23.76	86	41281	156692	34758872
Multiple organ dysfunction syndrome	33.47	23.76	25	41342	76541	34839023
Dysphagia	33.40	23.76	16	41351	62365	34853199
Angioedema	33.18	23.76	3	41364	37371	34878193
Hallucination	32.90	23.76	10	41357	51488	34864076
Shoulder operation	32.83	23.76	19	41348	1107	34914457
Fibromyalgia	32.58	23.76	28	41339	3072	34912492
Myalgia	32.43	23.76	31	41336	84079	34831485
White blood cell count increased	32.34	23.76	5	41362	41146	34874418
Rheumatoid factor increased	32.25	23.76	15	41352	553	34915011
Foetal exposure during pregnancy	31.42	23.76	4	41363	38097	34877467
Psoriatic arthropathy	31.18	23.76	71	41296	19727	34895837
Atrial fibrillation	31.17	23.76	61	41306	122332	34793232
Dyspepsia	31.12	23.76	105	41262	36627	34878937
Hip arthroplasty	30.84	23.76	32	41335	4447	34911117
Cerebral haemorrhage	30.49	23.76	3	41364	34934	34880630
Hypersensitivity	30.47	23.76	148	41219	60887	34854677
Hepatic fibrosis	30.09	23.76	32	41335	4575	34910989
Aggression	30.02	23.76	5	41362	38959	34876605
Muscle spasms	29.67	23.76	27	41340	74974	34840590
Asthenia	28.94	23.76	171	41196	245080	34670484
Anal squamous cell carcinoma	28.79	23.76	9	41358	107	34915457
Chronic kidney disease	28.20	23.76	7	41360	41203	34874361
Death	27.99	23.76	319	41048	397730	34517834
Rheumatoid factor	27.40	23.76	8	41359	74	34915490
Suicidal ideation	27.37	23.76	7	41360	40381	34875183
Prostate cancer	27.35	23.76	106	41261	39543	34876021
Nodular regenerative hyperplasia	27.26	23.76	16	41351	957	34914607
Jaundice	27.15	23.76	3	41364	31879	34883685
Hepatic steatosis	26.89	23.76	64	41303	18298	34897266
Epistaxis	26.79	23.76	18	41349	58233	34857331
Lesion excision	26.76	23.76	7	41360	41	34915523
Haemorrhage	26.26	23.76	14	41353	51356	34864208
Mass	26.05	23.76	39	41328	7866	34907698
Haemoptysis	25.87	23.76	5	41362	35001	34880563
Incorrect dose administered	25.64	23.76	8	41359	40507	34875057
Injection related reaction	25.37	23.76	11	41356	343	34915221
Off label use	25.30	23.76	662	40705	418862	34496702
Dental caries	25.28	23.76	29	41338	4510	34911054
Back disorder	25.11	23.76	35	41332	6616	34908948
Wrong technique in product usage process	24.84	23.76	6	41361	35980	34879584
Melaena	24.23	23.76	6	41361	35374	34880190
Stomatitis	24.09	23.76	107	41260	42407	34873157
Product use in unapproved indication	23.93	23.76	66	41301	117433	34798131
Abscess drainage	23.80	23.76	10	41357	288	34915276

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Joint swelling	7524.98	18.04	7343	308191	281303	79147551
Drug ineffective	6372.43	18.04	13449	302085	1067464	78361390
Contraindicated product administered	6175.71	18.04	5053	310481	152485	79276369
Synovitis	4662.22	18.04	4224	311310	146510	79282344
Drug intolerance	4596.96	18.04	5432	310102	258687	79170167
Arthralgia	3667.88	18.04	7395	308139	564408	78864446
Treatment failure	3436.49	18.04	3787	311747	166699	79262155
Arthropathy	3432.36	18.04	3854	311680	173257	79255597
Therapeutic product effect decreased	2695.07	18.04	3279	312255	160584	79268270
Pain	2321.83	18.04	7060	308474	696742	78732112
Hand deformity	2093.87	18.04	2310	313224	101609	79327245
C-reactive protein abnormal	1784.61	18.04	1501	314033	46866	79381988
Pemphigus	1779.05	18.04	2080	313454	97502	79331352
Systemic lupus erythematosus	1733.57	18.04	2263	313271	118886	79309968
Swelling	1708.28	18.04	3068	312466	213643	79215211
Rheumatoid arthritis	1655.44	18.04	2961	312573	205509	79223345
Glossodynia	1532.42	18.04	1965	313569	101372	79327482
Acute kidney injury	1526.24	18.04	147	315387	519257	78909597
Hypersensitivity	1489.95	18.04	3236	312298	259003	79169851
Hepatic enzyme increased	1462.55	18.04	2604	312930	180006	79248848
Anti-cyclic citrullinated peptide antibody positive	1450.44	18.04	1716	313818	81427	79347427
Rheumatoid factor positive	1447.80	18.04	1467	314067	58372	79370482
Red blood cell sedimentation rate abnormal	1433.43	18.04	943	314591	20020	79408834
Alopecia	1243.57	18.04	2793	312741	228562	79200292
Abdominal discomfort	1241.12	18.04	2930	312604	247797	79181057
Pericarditis	1223.62	18.04	1770	313764	102466	79326388
Drug interaction	1164.11	18.04	139	315395	415044	79013810
Wound	1159.44	18.04	1829	313705	114350	79314504
Drug hypersensitivity	1112.72	18.04	3138	312396	295778	79133076
Musculoskeletal stiffness	1069.49	18.04	2226	313308	172782	79256072
Hypotension	1060.38	18.04	225	315309	440092	78988762
Toxicity to various agents	1013.79	18.04	216	315318	421324	79007530
Anaemia	976.88	18.04	276	315258	444739	78984115
Infection	976.04	18.04	2615	312919	239097	79189757
Completed suicide	953.60	18.04	3	315531	245764	79183090
Helicobacter infection	933.02	18.04	1261	314273	68443	79360411
Peripheral swelling	918.69	18.04	2743	312791	266874	79161980
Therapy interrupted	897.52	18.04	843	314691	30498	79398356
Duodenal ulcer perforation	894.11	18.04	1203	314331	65008	79363846
Febrile neutropenia	838.66	18.04	15	315519	230984	79197870
Rash	814.73	18.04	4464	311070	573894	78854960
Discomfort	794.27	18.04	1621	313913	123996	79304858
Death	785.99	18.04	654	314880	565860	78862994
Red blood cell sedimentation rate increased	780.60	18.04	936	314598	45006	79383848
Muscle injury	754.96	18.04	946	314588	47615	79381239
Loss of personal independence in daily activities	744.59	18.04	1403	314131	101177	79327677
Folliculitis	742.76	18.04	1003	314531	54377	79374477
Irritable bowel syndrome	737.40	18.04	1062	314472	61179	79367675
Sleep disorder due to general medical condition, insomnia type	713.27	18.04	871	314663	42685	79386169
Impaired healing	711.00	18.04	1258	314276	86397	79342457
Mobility decreased	686.97	18.04	1503	314031	120672	79308182
Adverse event	682.23	18.04	1006	314528	59208	79369646
Lower respiratory tract infection	651.16	18.04	1522	314012	127698	79301156
Sinusitis	637.07	18.04	1959	313575	193542	79235312
Infusion related reaction	616.51	18.04	2158	313376	228079	79200775
Drug abuse	605.73	18.04	7	315527	162684	79266170
Bone erosion	593.15	18.04	522	315012	17325	79411529
Dehydration	580.28	18.04	135	315399	248052	79180802
Hyponatraemia	561.40	18.04	36	315498	177812	79251042
Blister	541.58	18.04	1351	314183	118125	79310729
Ill-defined disorder	538.71	18.04	949	314585	64926	79363928
Thrombocytopenia	536.02	18.04	190	315344	265069	79163785
Knee arthroplasty	535.85	18.04	754	314780	42494	79386360
Cardiac arrest	528.22	18.04	40	315494	172056	79256798
Maternal exposure during pregnancy	512.27	18.04	1439	314095	135099	79293755
Gastrointestinal disorder	511.57	18.04	1341	314193	120864	79307990
Seizure	509.80	18.04	71	315463	188763	79240091
Somnolence	505.89	18.04	158	315376	238823	79190031
Malignant neoplasm progression	501.14	18.04	7	315527	135983	79292871
Neutropenia	497.18	18.04	259	315275	287451	79141403
C-reactive protein increased	490.09	18.04	1366	314168	127661	79301193
Arthritis	486.36	18.04	1266	314268	113614	79315240
Rheumatoid nodule	463.05	18.04	450	315084	16988	79411866
Fibromyalgia	459.23	18.04	874	314660	63466	79365388
Inflammation	453.38	18.04	1087	314447	92666	79336188
Bradycardia	441.36	18.04	23	315511	135534	79293320
Tachycardia	433.08	18.04	88	315446	177680	79251174
Osteoarthritis	427.26	18.04	1017	314517	86292	79342562
Disease progression	425.48	18.04	103	315431	184259	79244595
Dyspnoea	425.08	18.04	1848	313686	855177	78573677
Gastrointestinal haemorrhage	414.48	18.04	49	315485	147670	79281184
Hyperkalaemia	412.68	18.04	8	315526	114390	79314464
Pancytopenia	412.28	18.04	78	315456	165667	79263187
Respiratory failure	409.88	18.04	105	315429	180806	79248048
Constipation	406.43	18.04	315	315219	282735	79146119
Product use issue	403.87	18.04	1773	313761	208049	79220805
Therapeutic product effect incomplete	398.23	18.04	1350	314184	140295	79288559
Cardio-respiratory arrest	398.02	18.04	6	315528	108504	79320350
Rheumatic fever	393.62	18.04	524	315010	28001	79400853
Platelet count decreased	390.47	18.04	141	315393	194523	79234331
Drug tolerance decreased	388.68	18.04	358	315176	12620	79416234
Rhabdomyolysis	372.87	18.04	7	315527	103124	79325730
Disability	371.14	18.04	396	315138	16724	79412130
Tremor	367.90	18.04	108	315426	169975	79258879
Hip arthroplasty	364.66	18.04	569	314965	35187	79393667
Foot deformity	361.39	18.04	461	315073	23613	79405241
Nasopharyngitis	360.78	18.04	1967	313567	251914	79176940
Depressed level of consciousness	355.98	18.04	5	315529	96647	79332207
Coma	348.01	18.04	11	315523	100638	79328216
Musculoskeletal pain	343.63	18.04	1037	314497	101317	79327537
Overdose	342.27	18.04	150	315384	184056	79244798
Electrocardiogram QT prolonged	340.50	18.04	3	315531	90383	79338471
Stomatitis	338.94	18.04	1312	314222	145445	79283409
Condition aggravated	334.85	18.04	3237	312297	497887	78930967
Multiple organ dysfunction syndrome	324.96	18.04	45	315489	120201	79308653
Abdominal pain	322.85	18.04	660	314874	388909	79039945
Hypoglycaemia	322.21	18.04	20	315514	101574	79327280
Psoriatic arthropathy	312.15	18.04	842	314692	77157	79351697
Panniculitis	307.56	18.04	308	315226	12063	79416791
Blood parathyroid hormone decreased	306.55	18.04	286	315248	10250	79418604
Fracture	306.21	18.04	404	315130	21397	79407457
Agitation	303.58	18.04	24	315510	99691	79329163
Coeliac disease	301.51	18.04	293	315241	11058	79417796
Joint range of motion decreased	298.98	18.04	500	315034	32782	79396072
Blood cholesterol increased	295.99	18.04	864	314670	82856	79345998
Device malfunction	294.38	18.04	393	315141	21055	79407799
Suicide attempt	294.38	18.04	7	315527	82925	79345929
International normalised ratio increased	293.84	18.04	9	315525	84712	79344142
Granuloma skin	292.23	18.04	262	315272	8912	79419942
Epistaxis	291.49	18.04	46	315488	111469	79317385
Swollen joint count increased	287.33	18.04	402	315132	22525	79406329
White blood cell count decreased	285.12	18.04	198	315336	188090	79240764
Dysphagia	284.16	18.04	67	315467	122069	79306785
Tenosynovitis	282.49	18.04	328	315206	15226	79413628
Metabolic acidosis	281.85	18.04	10	315524	82519	79346335
Neutrophil count decreased	279.48	18.04	25	315509	93934	79334920
Anxiety	278.67	18.04	344	315190	248168	79180686
Hallucination	277.66	18.04	15	315519	85730	79343124
Hypoxia	273.47	18.04	41	315493	103202	79325652
Dizziness	266.45	18.04	1125	314409	525316	78903538
Chest discomfort	263.46	18.04	108	315426	137936	79290918
Osteoporosis	258.91	18.04	625	314909	53487	79375367
Renal failure	254.08	18.04	252	315282	200716	79228138
Vomiting	253.15	18.04	1571	313963	664257	78764597
Syncope	252.02	18.04	204	315330	179245	79249609
Hypokalaemia	251.08	18.04	128	315406	143912	79284942
Ascites	242.26	18.04	14	315520	75548	79353306
Intentional product use issue	240.94	18.04	1215	314319	150897	79277957
Atrial fibrillation	239.01	18.04	258	315276	197628	79231226
Sepsis	235.55	18.04	442	315092	268986	79159868
Neuropathy peripheral	233.98	18.04	134	315400	141171	79287683
Decreased appetite	232.70	18.04	644	314890	341774	79087080
Balance disorder	232.40	18.04	53	315481	98804	79330050
Asthenia	232.28	18.04	1138	314396	510551	78918303
Dyspnoea exertional	231.95	18.04	34	315500	87039	79341815
Encephalopathy	230.73	18.04	8	315526	67389	79361465
Haemoglobin decreased	229.07	18.04	327	315207	221792	79207062
Cardiac failure congestive	227.41	18.04	141	315393	142261	79286593
Haematuria	223.01	18.04	12	315522	68824	79360030
Hyperglycaemia	222.56	18.04	14	315520	70321	79358533
Drug reaction with eosinophilia and systemic symptoms	222.15	18.04	7	315527	64237	79364617
Dysarthria	221.57	18.04	11	315523	67611	79361243
Blood pressure decreased	219.02	18.04	61	315473	99405	79329449
Hepatic function abnormal	213.31	18.04	21	315513	73086	79355768
Pyrexia	208.38	18.04	1703	313831	677006	78751848
Blood creatine phosphokinase increased	206.62	18.04	14	315520	66076	79362778
Sciatica	206.48	18.04	426	315108	32796	79396058
Melaena	205.78	18.04	8	315526	60882	79367972
Deformity	204.36	18.04	220	315314	9385	79419469
Blood bilirubin increased	204.26	18.04	15	315519	66217	79362637
Bursitis	203.53	18.04	443	315091	35401	79393453
Blood glucose increased	202.13	18.04	101	315433	114874	79313980
Vision blurred	201.82	18.04	83	315451	105815	79323039
Blood creatinine increased	198.76	18.04	192	315342	154865	79273989
Sleep disorder	198.53	18.04	767	314767	84910	79343944
Unresponsive to stimuli	196.88	18.04	5	315529	55783	79373071
Myalgia	195.67	18.04	269	315265	185372	79243482
Cerebrovascular accident	194.78	18.04	196	315338	155096	79273758
Disorientation	194.22	18.04	14	315520	62762	79366092
Cognitive disorder	194.11	18.04	24	315510	69902	79358952
Diarrhoea	193.24	18.04	2395	313139	878094	78550760
Pulmonary embolism	191.93	18.04	238	315296	171416	79257438
Cardiac failure	191.30	18.04	198	315336	154644	79274210
Neoplasm progression	188.90	18.04	3	315531	51679	79377175
Hepatic failure	188.38	18.04	14	315520	61198	79367656
Skin ulcer	187.68	18.04	555	314979	53595	79375259
Rectal haemorrhage	183.20	18.04	39	315495	76261	79352593
Pulmonary fibrosis	179.25	18.04	479	315055	43633	79385221
Type 2 diabetes mellitus	177.94	18.04	564	314970	56558	79372296
Dislocation of vertebra	177.41	18.04	186	315348	7694	79421160
Jaundice	176.98	18.04	8	315526	53341	79375513
Pulmonary oedema	176.74	18.04	64	315470	88190	79340664
Palpitations	176.40	18.04	145	315389	126465	79302389
Basal cell carcinoma	175.90	18.04	429	315105	36946	79391908
Acute myocardial infarction	175.76	18.04	44	315490	76992	79351862
Oedema peripheral	174.66	18.04	470	315064	251818	79177036
Oxygen saturation decreased	174.64	18.04	152	315382	128895	79299959
Temperature regulation disorder	174.37	18.04	161	315373	5692	79423162
Blood alkaline phosphatase increased	173.94	18.04	23	315511	63641	79365213
Lethargy	173.20	18.04	53	315481	81239	79347615
Intentional product misuse	172.77	18.04	80	315454	95085	79333769
Joint destruction	172.69	18.04	161	315373	5764	79423090
Diverticulitis	171.93	18.04	484	315050	45452	79383402
Suicidal ideation	171.49	18.04	45	315489	76295	79352559
Musculoskeletal disorder	171.39	18.04	306	315228	21142	79407712
Chills	171.06	18.04	230	315304	160004	79268850
Joint stiffness	170.62	18.04	448	315086	40382	79388472
Blood urea increased	169.84	18.04	5	315529	48785	79380069
Apparent death	169.79	18.04	118	315416	2747	79426107
Immunodeficiency	169.40	18.04	307	315227	21461	79407393
Pneumonia aspiration	167.55	18.04	31	315503	66936	79361918
Pleural effusion	167.06	18.04	197	315337	145065	79283789
Incorrect dose administered	166.84	18.04	48	315486	76582	79352272
Haematemesis	166.57	18.04	10	315524	52254	79376600
Haemoptysis	166.26	18.04	15	315519	55984	79372870
Dysgeusia	165.31	18.04	17	315517	57160	79371694
Therapeutic response decreased	165.22	18.04	611	314923	66242	79362612
Skin necrosis	164.13	18.04	273	315261	17814	79411040
Respiratory arrest	164.11	18.04	18	315516	57532	79371322
Rheumatoid factor negative	163.90	18.04	84	315450	1089	79427765
Haemorrhage	161.73	18.04	79	315455	91039	79337815
Fine motor skill dysfunction	160.84	18.04	148	315386	5209	79423645
Chest pain	159.33	18.04	577	314957	281727	79147127
Prescribed overdose	158.64	18.04	416	315118	37467	79391387
Hepatocellular injury	158.32	18.04	7	315527	47586	79381268
Urinary retention	158.26	18.04	19	315515	56611	79372243
Disturbance in attention	158.11	18.04	11	315523	50790	79378064
Elbow deformity	158.06	18.04	90	315444	1457	79427397
Wrong technique in product usage process	157.69	18.04	48	315486	73827	79355027
Fall	157.09	18.04	1207	314327	486422	78942432
Adverse drug reaction	156.78	18.04	598	314936	65794	79363060
Coronary artery disease	156.10	18.04	34	315500	65440	79363414
Aggression	155.83	18.04	12	315522	50946	79377908
Dyskinesia	154.37	18.04	5	315529	44768	79384086
Multiple sclerosis relapse	154.28	18.04	7	315527	46526	79382328
Arthrodesis	151.77	18.04	103	315431	2304	79426550
Plasma cell myeloma	151	18.04	17	315517	53242	79375612
Cerebral haemorrhage	150.22	18.04	24	315510	57649	79371205
Orthostatic hypotension	149.42	18.04	22	315512	56142	79372712
Injection site pain	149.39	18.04	176	315358	129662	79299192
Renal impairment	148.51	18.04	247	315287	157536	79271318
Aphasia	145.79	18.04	10	315524	46722	79382132
Finger deformity	144.82	18.04	163	315371	7311	79421543
Flushing	144.25	18.04	85	315449	88183	79340671
Weight decreased	144.17	18.04	820	314714	354378	79074476
Nausea	144.12	18.04	2797	312737	954399	78474455
Mental status changes	143.84	18.04	43	315491	66916	79361938
Pancreatitis acute	142.75	18.04	15	315519	49589	79379265
Pallor	141.88	18.04	16	315518	50046	79378808
Respiratory distress	141.74	18.04	29	315505	58310	79370544
Grip strength decreased	141.31	18.04	285	315249	21584	79407270
Oral mucosal exfoliation	140.03	18.04	82	315452	1403	79427451
Joint laxity	139.99	18.04	97	315437	2247	79426607
Gastric disorder	139.69	18.04	394	315140	37039	79391815
Full blood count abnormal	137.85	18.04	5	315529	40469	79388385
Shock	136.79	18.04	9	315525	43539	79385315
Blood lactate dehydrogenase increased	136.40	18.04	4	315530	39166	79389688
Impaired work ability	136.24	18.04	264	315270	19417	79409437
Glaucoma	135.48	18.04	264	315270	19497	79409357
Physical disability	135.43	18.04	109	315425	3189	79425665
Heart rate increased	135.33	18.04	167	315367	120557	79308297
Rheumatoid lung	134.74	18.04	121	315413	4124	79424730
Accidental overdose	134.43	18.04	5	315529	39576	79389278
SLE arthritis	133.61	18.04	59	315475	534	79428320
Loss of consciousness	133.45	18.04	291	315243	167652	79261202
Cholestasis	132.79	18.04	23	315511	52086	79376768
Tubulointerstitial nephritis	132.79	18.04	4	315530	38231	79390623
Acute respiratory failure	132.03	18.04	36	315498	59505	79369349
Angioedema	131.82	18.04	68	315466	75967	79352887
Limb deformity	131.43	18.04	111	315423	3479	79425375
Musculoskeletal deformity	131.32	18.04	80	315454	1476	79427378
Gamma-glutamyltransferase increased	131.16	18.04	28	315506	54652	79374202
Human antichimeric antibody positive	129.92	18.04	81	315453	1560	79427294
Polyarthritis	129.74	18.04	198	315336	12004	79416850
Abnormal behaviour	129.53	18.04	3	315531	36418	79392436
Emotional distress	129.36	18.04	7	315527	39962	79388892
Upper gastrointestinal haemorrhage	128.66	18.04	9	315525	41371	79387483
Enthesopathy	128.59	18.04	192	315342	11416	79417438
Hypophagia	127.32	18.04	15	315519	45352	79383502
Eosinophilia	127.24	18.04	15	315519	45330	79383524
Agranulocytosis	126.10	18.04	15	315519	45015	79383839
Haematochezia	125.04	18.04	98	315436	87547	79341307
Bone marrow failure	125.01	18.04	25	315509	51082	79377772
Red blood cell sedimentation rate	124.65	18.04	131	315403	5434	79423420
Herpes zoster	124.49	18.04	710	314824	92373	79336481
Coagulopathy	124.21	18.04	4	315530	36002	79392852
Breast cancer stage III	124.17	18.04	173	315361	9653	79419201
Hypervolaemia	122.62	18.04	13	315521	42677	79386177
Ventricular tachycardia	122.45	18.04	12	315522	41923	79386931
Restlessness	121.87	18.04	19	315515	46473	79382381
Pneumonia	121.50	18.04	1860	313674	658386	78770468
Night sweats	121.16	18.04	467	315067	51628	79377226
Circulatory collapse	120.67	18.04	7	315527	37661	79391193
Psychotic disorder	120.49	18.04	12	315522	41390	79387464
Stevens-Johnson syndrome	120.39	18.04	9	315525	39157	79389697
Body height below normal	120.36	18.04	84	315450	1969	79426885
Generalised tonic-clonic seizure	119.62	18.04	16	315518	43894	79384960
Alanine aminotransferase abnormal	119.41	18.04	161	315373	8706	79420148
Pulmonary hypertension	118.69	18.04	23	315511	48057	79380797
Ulcer	118.29	18.04	322	315212	29650	79399204
Product prescribing error	118.18	18.04	18	315516	44795	79384059
Joint arthroplasty	117.73	18.04	93	315441	2647	79426207
Skin exfoliation	117.24	18.04	36	315498	55064	79373790
Cough	117.01	18.04	910	314624	365879	79062975
Altered state of consciousness	116.95	18.04	17	315517	43805	79385049
Drug withdrawal syndrome	115.83	18.04	5	315529	34713	79394141
Blood pressure increased	114.63	18.04	439	315095	210921	79217933
Irritability	114.49	18.04	14	315520	41130	79387724
Intentional self-injury	114.03	18.04	3	315531	32416	79396438
Depressed mood	113.91	18.04	26	315508	48454	79380400
Contusion	113.04	18.04	989	314545	147787	79281067
Cardiogenic shock	112.47	18.04	16	315518	41898	79386956
Ear pain	112.09	18.04	335	315199	32534	79396320
Seronegative arthritis	111.48	18.04	114	315420	4578	79424276
Food allergy	111.38	18.04	173	315361	10651	79418203
Lymphocyte count decreased	109.84	18.04	26	315508	47263	79381591
Joint injury	109.36	18.04	322	315212	31013	79397841
Tachypnoea	109.06	18.04	4	315530	32059	79396795
Onychomycosis	108.22	18.04	148	315386	8113	79420741
Blood calcium decreased	108.13	18.04	4	315530	31815	79397039
Disseminated intravascular coagulation	108.03	18.04	9	315525	35833	79393021
Chronic kidney disease	107.68	18.04	64	315470	66090	79362764
Abdominal distension	107.38	18.04	193	315341	119457	79309397
Nodule	107.20	18.04	263	315271	22731	79406123
Arrhythmia	105.91	18.04	55	315479	61217	79367637
Lower limb fracture	105.56	18.04	263	315271	22952	79405902
Liver function test increased	105.47	18.04	372	315162	39401	79389453
Acute respiratory distress syndrome	104.81	18.04	23	315511	44044	79384810
Leukocytosis	104.74	18.04	22	315512	43433	79385421
Mucosal inflammation	104.71	18.04	87	315447	75493	79353361
Drug ineffective for unapproved indication	104.56	18.04	36	315498	51202	79377652
Wrist deformity	104.42	18.04	78	315456	2039	79426815
Fatigue	104.09	18.04	4582	310952	925145	78503709
Swollen tongue	103.75	18.04	21	315513	42549	79386305
Bone pain	100.95	18.04	47	315487	55695	79373159
Speech disorder	100.01	18.04	45	315489	54400	79374454
Anti-cyclic citrullinated peptide antibody	98.96	18.04	119	315415	5733	79423121
Exostosis	98.72	18.04	211	315323	16647	79412207
Acute hepatic failure	98.32	18.04	5	315529	30108	79398746
Urinary incontinence	98.01	18.04	21	315513	40888	79387966
Bone swelling	97.86	18.04	69	315465	1645	79427209
Swelling face	97.39	18.04	83	315451	71129	79357725
Drug use disorder	97.13	18.04	144	315390	8507	79420347
Prescribed underdose	97.06	18.04	297	315237	29217	79399637
Diabetic ketoacidosis	96.46	18.04	11	315523	34111	79394743
Osteonecrosis of jaw	96.09	18.04	26	315508	43200	79385654
Liver injury	95.81	18.04	461	315073	56153	79372701
Surgical failure	95.41	18.04	53	315481	816	79428038
Electrolyte imbalance	95.19	18.04	7	315527	30874	79397980
Sinus tachycardia	94.69	18.04	16	315518	36892	79391962
Deep vein thrombosis	94.00	18.04	212	315322	120707	79308147
Pneumonitis	93.39	18.04	63	315471	60797	79368057
Muscle spasticity	93.17	18.04	239	315295	21236	79407618
Presyncope	92.58	18.04	24	315510	41030	79387824
Tongue disorder	92.53	18.04	184	315350	13791	79415063
Lip swelling	92.10	18.04	24	315510	40887	79387967
Dry skin	92.07	18.04	80	315454	67915	79360939
Subdural haematoma	91.77	18.04	9	315525	31425	79397429
Joint effusion	91.48	18.04	213	315321	17801	79411053
Blood potassium decreased	90.98	18.04	35	315499	46477	79382377
Blood sodium decreased	90.87	18.04	12	315522	33243	79395611
Device defective	90.84	18.04	69	315465	1851	79427003
Haemorrhage intracranial	90.03	18.04	3	315531	26190	79402664
Muscle spasms	88.98	18.04	372	315162	174358	79254496
Myocardial infarction	88.89	18.04	400	315134	183729	79245125
Nightmare	88.75	18.04	3	315531	25858	79402996
Facet joint syndrome	88.70	18.04	160	315374	11142	79417712
Hemiparesis	87.93	18.04	14	315520	33719	79395135
Feeling abnormal	87.37	18.04	329	315205	158870	79269984
Inappropriate antidiuretic hormone secretion	87.10	18.04	4	315530	26309	79402545
Pericardial effusion	86.85	18.04	37	315497	46200	79382654
Sinus bradycardia	86.40	18.04	3	315531	25244	79403610
Spinal instability	86.09	18.04	40	315494	412	79428442
Device dislocation	85.79	18.04	4	315530	25966	79402888
Pollakiuria	85.72	18.04	21	315513	37296	79391558
Loose body in joint	85.45	18.04	57	315477	1238	79427616
Deep vein thrombosis postoperative	85.39	18.04	153	315381	10599	79418255
Bone density decreased	85.11	18.04	173	315361	13174	79415680
Blood iron abnormal	85.01	18.04	58	315476	1309	79427545
Tuberculin test positive	84.99	18.04	85	315449	3323	79425531
Chromaturia	84.94	18.04	4	315530	25742	79403112
Vertigo	84.53	18.04	89	315445	68993	79359861
Atlantoaxial instability	84.07	18.04	35	315499	270	79428584
Injection site erythema	83.66	18.04	112	315422	78085	79350769
Lip dry	83.50	18.04	187	315347	15231	79413623
Gastrooesophageal reflux disease	83.31	18.04	180	315354	104066	79324788
Intestinal sepsis	83.08	18.04	49	315485	850	79428004
Mineral metabolism disorder	82.55	18.04	35	315499	284	79428570
Face oedema	82.28	18.04	8	315526	28128	79400726
Multiple fractures	82.19	18.04	128	315406	7898	79420956
X-ray abnormal	82.05	18.04	108	315426	5705	79423149
Colitis microscopic	81.42	18.04	150	315384	10618	79418236
Device related infection	81.36	18.04	18	315516	34276	79394578
Osteoporotic fracture	81.35	18.04	92	315442	4148	79424706
Hepatic cytolysis	81.33	18.04	7	315527	27144	79401710
Lymphopenia	81.21	18.04	12	315522	30545	79398309
Adjustment disorder with depressed mood	80.91	18.04	136	315398	8950	79419904
Thyroid neoplasm	80.91	18.04	80	315454	3084	79425770
Diplopia	80.54	18.04	17	315517	33449	79395405
Terminal state	80.36	18.04	98	315436	4791	79424063
Premature delivery	79.57	18.04	3	315531	23464	79405390
Product dose omission issue	79.40	18.04	613	314921	246924	79181930
Myelosuppression	79.36	18.04	30	315504	40266	79388588
Joint dislocation	79.23	18.04	194	315340	16745	79412109
Dysuria	79.18	18.04	52	315482	50899	79377955
Chronic obstructive pulmonary disease	79.16	18.04	135	315399	85284	79343570
Ataxia	79.16	18.04	5	315529	25034	79403820
Pain in extremity	78.96	18.04	1944	313590	362594	79066260
Bronchitis chronic	78.85	18.04	93	315441	4389	79424465
Upper respiratory tract infection	78.80	18.04	624	314910	90544	79338310
Mitral valve incompetence	78.79	18.04	10	315524	28555	79400299
Obstructive airways disorder	77.76	18.04	15	315519	31444	79397410
Wheelchair user	77.54	18.04	108	315426	6024	79422830
Presbyacusis	76.98	18.04	72	315462	2588	79426266
Dermatitis allergic	76.83	18.04	200	315334	17930	79410924
Hypothyroidism	76.75	18.04	57	315477	52335	79376519
Clostridium difficile colitis	76.47	18.04	17	315517	32266	79396588
Bacteraemia	76.33	18.04	18	315516	32806	79396048
Illness	76.02	18.04	375	315159	46136	79382718
Muscle twitching	75.24	18.04	6	315528	24758	79404096
Full blood count decreased	74.93	18.04	9	315525	26810	79402044
Ankle operation	74.36	18.04	49	315485	1042	79427812
Obesity	73.74	18.04	305	315229	34820	79394034
Femur fracture	73.72	18.04	326	315208	38326	79390528
Liver disorder	73.56	18.04	515	315019	71902	79356952
Staphylococcal infection	72.57	18.04	74	315460	58221	79370633
Infusion site reaction	72.54	18.04	79	315455	3414	79425440
Anticipatory anxiety	72.31	18.04	50	315484	1154	79427700
Toxic skin eruption	71.85	18.04	4	315530	22289	79406565
Therapy non-responder	71.85	18.04	617	314917	91688	79337166
Hypersomnia	71.83	18.04	5	315529	23081	79405773
Small intestinal obstruction	71.81	18.04	11	315523	27261	79401593
Acute myeloid leukaemia	71.69	18.04	17	315517	30868	79397986
Cyanosis	71.48	18.04	8	315526	25174	79403680
Septic shock	71.19	18.04	248	315286	122553	79306301
Drug eruption	70.93	18.04	353	315181	43582	79385272
Abdominal pain lower	70.87	18.04	19	315515	31763	79397091
Spinal stenosis	70.85	18.04	178	315356	15613	79413241
Nervousness	70.78	18.04	22	315512	33393	79395461
Gastritis	70.58	18.04	52	315482	47941	79380913
Glomerular filtration rate decreased	70.40	18.04	5	315529	22697	79406157
Ileus	70.34	18.04	10	315524	26201	79402653
Hyperhidrosis	70.20	18.04	334	315200	151158	79277696
Bone cyst	70.18	18.04	77	315457	3356	79425498
Product storage error	69.79	18.04	180	315354	16046	79412808
Cytomegalovirus infection	69.76	18.04	41	315493	42603	79386251
Pancreatitis	69.59	18.04	102	315432	68473	79360381
Gait inability	69.53	18.04	435	315099	58482	79370372
Product use in unapproved indication	69.49	18.04	644	314890	249715	79179139
Inappropriate schedule of product administration	68.95	18.04	283	315251	133345	79295509
Visual acuity reduced	68.84	18.04	16	315518	29453	79399401
Metastases to bone	68.73	18.04	8	315526	24419	79404435
Adverse reaction	68.24	18.04	128	315406	9186	79419668
Cerebral infarction	67.81	18.04	49	315485	45627	79383227
Hypothermia	67.77	18.04	6	315528	22740	79406114
Paraesthesia	67.74	18.04	414	315120	175909	79252945
Extrapyramidal disorder	67.52	18.04	6	315528	22673	79406181
White blood cell count increased	67.29	18.04	120	315414	74513	79354341
Limb discomfort	67.21	18.04	283	315251	32567	79396287
Blood triglycerides increased	67.12	18.04	4	315530	21036	79407818
Aspiration	66.93	18.04	3	315531	20155	79408699
Wound infection	66.74	18.04	228	315306	23763	79405091
Ischaemic stroke	66.36	18.04	24	315510	33107	79395747
Crying	66.22	18.04	7	315527	23036	79405818
Mental disorder	65.61	18.04	21	315513	31281	79397573
Transient ischaemic attack	65.47	18.04	67	315467	52628	79376226
Transfusion	65.28	18.04	5	315529	21325	79407529
Frequent bowel movements	65.22	18.04	18	315516	29521	79399333
Hypoalbuminaemia	65.16	18.04	5	315529	21292	79407562
Systemic lupus erythematosus rash	65.01	18.04	56	315478	1804	79427050
Onychomadesis	64.31	18.04	91	315443	5151	79423703
Paranoia	64.17	18.04	3	315531	19429	79409425
Skin discolouration	63.60	18.04	42	315492	40992	79387862
Myocardial ischaemia	63.43	18.04	12	315522	25507	79403347
Osteonecrosis	63.18	18.04	22	315512	31073	79397781
Peripheral venous disease	62.85	18.04	171	315363	15738	79413116
Osteosclerosis	62.69	18.04	78	315456	3893	79424961
Bone disorder	62.53	18.04	192	315342	18921	79409933
Myelodysplastic syndrome	62.33	18.04	21	315513	30280	79398574
Foot operation	62.32	18.04	94	315440	5639	79423215
Cardiac failure acute	62.25	18.04	3	315531	18926	79409928
Tricuspid valve incompetence	62.12	18.04	4	315530	19708	79409146
Cholelithiasis	62.05	18.04	70	315464	52594	79376260
Posterior reversible encephalopathy syndrome	61.93	18.04	14	315520	26267	79402587
Sudden death	61.80	18.04	8	315526	22503	79406351
Malnutrition	61.77	18.04	8	315526	22494	79406360
Hyperthyroidism	60.72	18.04	8	315526	22201	79406653
Feeling cold	60.70	18.04	19	315515	28710	79400144
Angina pectoris	60.69	18.04	69	315465	51663	79377191
Flatulence	60.64	18.04	48	315486	42676	79386178
Retinitis	60.60	18.04	92	315442	5551	79423303
Mesenteritis	60.28	18.04	29	315505	325	79428529
Dystonia	60.23	18.04	7	315527	21392	79407462
Maternal exposure timing unspecified	60.19	18.04	93	315441	5699	79423155
Therapeutic response unexpected	60.14	18.04	5	315529	19941	79408913
Myopathy	59.73	18.04	6	315528	20557	79408297
Mental impairment	59.59	18.04	4	315530	19032	79409822
Anal incontinence	59.37	18.04	3	315531	18165	79410689
Drug resistance	59.20	18.04	48	315486	42165	79386689
Drug specific antibody	59.10	18.04	62	315472	2566	79426288
Accidental exposure to product	58.93	18.04	25	315509	31297	79397557
Hypercholesterolaemia	58.65	18.04	213	315321	22882	79405972
Atrial flutter	58.62	18.04	8	315526	21617	79407237
Right ventricular failure	58.51	18.04	11	315523	23486	79405368
Heart rate irregular	58.48	18.04	28	315506	32651	79396203
Thirst	58.03	18.04	4	315530	18615	79410239
Left ventricular dysfunction	57.97	18.04	5	315529	19356	79409498
Nail disorder	57.86	18.04	138	315396	11714	79417140
Blood pressure fluctuation	57.84	18.04	111	315423	67034	79361820
Subarachnoid haemorrhage	57.71	18.04	13	315521	24452	79404402
Colitis	57.39	18.04	128	315406	73179	79355675
Drug tolerance	57.17	18.04	114	315420	8561	79420293
Urticaria	56.70	18.04	1039	314495	184162	79244692
Arteriosclerosis	56.56	18.04	4	315530	18223	79410631
Demyelination	55.99	18.04	108	315426	7915	79420939
Nasal congestion	55.67	18.04	139	315395	76413	79352441
Clostridium difficile infection	55.66	18.04	52	315482	42633	79386221
Haematoma	55.58	18.04	75	315459	52120	79376734
Live birth	55.57	18.04	182	315352	18562	79410292
Tinnitus	55.50	18.04	56	315478	44277	79384577
Vascular access complication	55.48	18.04	55	315479	2127	79426727
Epilepsy	55.41	18.04	48	315486	40812	79388042
Rash maculo-papular	55.36	18.04	85	315449	55993	79372861
Eosinophil count increased	55.34	18.04	3	315531	17102	79411752
Panic attack	54.90	18.04	14	315520	24202	79404652
Red cell distribution width decreased	54.86	18.04	53	315481	1985	79426869
Pleural thickening	54.34	18.04	63	315471	2919	79425935
Sleep apnoea syndrome	54.32	18.04	39	315495	36439	79392415
Intestinal obstruction	54.25	18.04	54	315480	42966	79385888
Cytopenia	54.18	18.04	8	315526	20375	79408479
Ventricular extrasystoles	54.10	18.04	7	315527	19697	79409157
Sebaceous gland infection	53.95	18.04	22	315512	160	79428694
Hyperlipidaemia	53.82	18.04	18	315516	26075	79402779
Pleural fibrosis	53.60	18.04	74	315460	4093	79424761
Leukopenia	53.32	18.04	258	315276	116255	79312599
Splenomegaly	53.23	18.04	9	315525	20745	79408109
Pulmonary arterial hypertension	52.79	18.04	23	315511	28343	79400511
Hypercalcaemia	52.59	18.04	295	315239	38135	79390719
Blood glucose decreased	52.55	18.04	19	315515	26215	79402639
Troponin increased	52.49	18.04	7	315527	19248	79409606
Arteriosclerosis coronary artery	52.27	18.04	5	315529	17811	79411043
Cellulitis	51.96	18.04	238	315296	108822	79320032
Eczema	51.74	18.04	51	315483	40767	79388087
Heart rate decreased	51.66	18.04	127	315407	70189	79358665
Rash papular	50.99	18.04	12	315522	21904	79406950
Shock haemorrhagic	50.79	18.04	9	315525	20051	79408803
Haemophagocytic lymphohistiocytosis	50.72	18.04	12	315522	21825	79407029
Ageusia	50.61	18.04	4	315530	16628	79412226
Head injury	50.55	18.04	44	315490	37325	79391529
Hyperthermia	50.52	18.04	6	315528	18031	79410823
Urine output decreased	50.47	18.04	6	315528	18016	79410838
Peritonitis	50.20	18.04	24	315510	28012	79400842
Blood magnesium decreased	50.17	18.04	4	315530	16508	79412346
Synovial cyst	50.00	18.04	118	315416	9947	79418907
Eye swelling	50.00	18.04	21	315513	26447	79402407
Enterococcal infection	49.89	18.04	3	315531	15657	79413197
Autoimmune disorder	49.87	18.04	162	315372	16450	79412404
Muscular weakness	49.66	18.04	402	315132	160327	79268527
Ankle arthroplasty	49.45	18.04	44	315490	1481	79427373
Oliguria	49.41	18.04	4	315530	16305	79412549
Hypovolaemia	49.27	18.04	6	315528	17685	79411169
Pulmonary thrombosis	49.27	18.04	132	315402	12039	79416815
Mean platelet volume decreased	49.26	18.04	58	315476	2732	79426122
Wrist surgery	49.24	18.04	34	315500	783	79428071
Bunion operation	49.03	18.04	36	315498	916	79427938
Mania	48.92	18.04	7	315527	18253	79410601
Acute coronary syndrome	48.33	18.04	12	315522	21121	79407733
Skin cancer	48.20	18.04	150	315384	14890	79413964
Metastases to liver	48.07	18.04	26	315508	28288	79400566
Paraesthesia oral	48.05	18.04	11	315523	20460	79408394
Cardiomyopathy	48.01	18.04	27	315507	28747	79400107
Oesophagitis	47.97	18.04	18	315516	24271	79404583
Polyuria	47.46	18.04	3	315531	15011	79413843
Dialysis	47.36	18.04	8	315526	18454	79410400
Feeling hot	47.01	18.04	104	315430	59630	79369224
Tendonitis	46.97	18.04	203	315331	23627	79405227
Blindness	46.83	18.04	27	315507	28356	79400498
Erythema multiforme	46.75	18.04	7	315527	17644	79411210
Transplant rejection	46.52	18.04	10	315524	19427	79409427
Product administration error	46.19	18.04	35	315499	31811	79397043
Blood albumin decreased	46.17	18.04	19	315515	24224	79404630
Spinal column injury	46.15	18.04	50	315484	2148	79426706
Retching	46.09	18.04	7	315527	17460	79411394
Surgery	45.82	18.04	253	315281	32513	79396341
Neutrophil count increased	45.67	18.04	30	315504	29366	79399488
Hepatitis B virus test positive	45.60	18.04	27	315507	472	79428382
Breast cancer	45.36	18.04	258	315276	33523	79395331
Pathogen resistance	44.93	18.04	3	315531	14339	79414515
Faeces discoloured	44.88	18.04	30	315504	29097	79399757
Atelectasis	44.83	18.04	37	315497	32220	79396634
Purpura	44.83	18.04	11	315523	19516	79409338
Gastric haemorrhage	44.75	18.04	4	315530	15046	79413808
Incontinence	44.27	18.04	3	315531	14161	79414693
Sensitivity to weather change	44.02	18.04	98	315436	7949	79420905
Skin neoplasm excision	43.75	18.04	35	315499	1015	79427839
C-reactive protein	43.64	18.04	74	315460	4905	79423949
Schizophrenia	43.58	18.04	5	315529	15435	79413419
Bronchospasm	43.42	18.04	22	315512	24837	79404017
Disease recurrence	43.40	18.04	67	315467	44042	79384812
Vaginal haemorrhage	43.37	18.04	16	315518	21801	79407053
Bronchopulmonary aspergillosis	43.23	18.04	17	315517	22277	79406577
Blood magnesium increased	43.22	18.04	61	315473	3445	79425409
Depression	43.08	18.04	601	314933	216189	79212665
Device safety feature issue	42.75	18.04	10	315524	3	79428851
Ovarian neoplasm	42.59	18.04	28	315506	593	79428261
Hypernatraemia	42.55	18.04	4	315530	14447	79414407
Foot fracture	42.37	18.04	186	315348	21795	79407059
Chondropathy	42.34	18.04	51	315483	2461	79426393
Duodenal ulcer	42.20	18.04	7	315527	16362	79412492
Dermatitis bullous	41.79	18.04	4	315530	14241	79414613
Respiratory tract congestion	41.67	18.04	173	315361	19781	79409073
Supraventricular tachycardia	41.61	18.04	16	315518	21254	79407600
Injection site reaction	41.47	18.04	364	315170	54421	79374433
Thrombotic microangiopathy	41.45	18.04	14	315520	20155	79408699
Ankle deformity	41.43	18.04	29	315505	683	79428171
Blood loss anaemia	41.38	18.04	6	315528	15492	79413362
Limb operation	41.33	18.04	59	315475	3367	79425487
Delirium	41.32	18.04	183	315351	84444	79344410
Weight increased	40.92	18.04	1410	314124	275976	79152878
Pain assessment	40.83	18.04	9	315525	0	79428854
Hepatomegaly	40.75	18.04	12	315522	18862	79409992
Pemphigoid	40.73	18.04	6	315528	15309	79413545
Concomitant disease aggravated	40.54	18.04	3	315531	13164	79415690
Thinking abnormal	40.52	18.04	3	315531	13158	79415696
Lung infiltration	40.44	18.04	20	315514	22892	79405962
Respiratory disorder	40.39	18.04	310	315224	44546	79384308
Rash macular	40.35	18.04	33	315501	28866	79399988
Haematocrit decreased	40.30	18.04	117	315417	61195	79367659
Peripheral sensory neuropathy	40.04	18.04	3	315531	13030	79415824
Klebsiella infection	39.92	18.04	7	315527	15713	79413141
Poor quality sleep	39.85	18.04	20	315514	22702	79406152
Loss of employment	39.54	18.04	50	315484	2537	79426317
Osteopenia	38.97	18.04	160	315374	18204	79410650
Hypoaesthesia oral	38.82	18.04	5	315529	14119	79414735
Pseudomonas infection	38.82	18.04	17	315517	20886	79407968
Transaminases abnormal	38.64	18.04	30	315504	832	79428022
Throat irritation	38.59	18.04	64	315470	40882	79387972
Coronary artery occlusion	38.50	18.04	7	315527	15308	79413546
Pain of skin	38.23	18.04	6	315528	14607	79414247
Infiltration anaesthesia	38.20	18.04	17	315517	157	79428697
Cardiomegaly	38.17	18.04	29	315505	26323	79402531
Cardiac murmur	38.16	18.04	8	315526	15816	79413038
Metastases to central nervous system	38.03	18.04	9	315525	16366	79412488
Lupus-like syndrome	37.94	18.04	131	315403	13726	79415128
Sensory disturbance	37.66	18.04	7	315527	15070	79413784
Hypocalcaemia	37.60	18.04	89	315445	49835	79379019
Proteinuria	37.42	18.04	44	315490	32458	79396396
Hemiplegia	37.18	18.04	7	315527	14932	79413922
Dysphonia	37.04	18.04	109	315425	56763	79372091
Hepatitis	37.00	18.04	360	315174	55367	79373487
Glycosylated haemoglobin increased	36.83	18.04	15	315519	19245	79409609
Hypotonia	36.75	18.04	4	315530	12866	79415988
Peripheral coldness	36.66	18.04	9	315525	15961	79412893
Myositis	36.54	18.04	15	315519	19153	79409701
Pneumothorax	36.35	18.04	35	315499	28288	79400566
Cataract	36.33	18.04	391	315143	61729	79367125
Rhinorrhoea	36.24	18.04	166	315368	75908	79352946
Escherichia infection	36.17	18.04	13	315521	18004	79410850
Rales	36	18.04	17	315517	19984	79408870
Cardiac disorder	35.98	18.04	136	315398	65621	79363233
Micturition urgency	35.92	18.04	4	315530	12637	79416217
Impaired gastric emptying	35.75	18.04	106	315428	10247	79418607
Skin reaction	35.69	18.04	142	315392	15926	79412928
Mood altered	35.62	18.04	13	315521	17834	79411020
Transaminases increased	35.30	18.04	97	315437	51646	79377208
Pruritus	35.06	18.04	1903	313631	392745	79036109
Cold sweat	35.06	18.04	15	315519	18684	79410170
Metastases to lung	34.97	18.04	14	315520	18149	79410705
Cutaneous vasculitis	34.93	18.04	91	315443	8161	79420693
Investigation abnormal	34.91	18.04	42	315492	2024	79426830
Bedridden	34.66	18.04	116	315418	11963	79416891
Productive cough	34.64	18.04	206	315328	88125	79340729
Bundle branch block left	34.40	18.04	3	315531	11510	79417344
Hyperaesthesia	34.39	18.04	4	315530	12218	79416636
Intestinal polyp	34.30	18.04	42	315492	2062	79426792
Fracture delayed union	34.20	18.04	42	315492	2068	79426786
Sinus congestion	34.17	18.04	18	315516	19878	79408976
Atrioventricular block	34.06	18.04	7	315527	14034	79414820
Myocarditis	34.01	18.04	22	315512	21711	79407143
Lymphadenopathy	34.00	18.04	103	315431	53144	79375710
Enteritis	33.90	18.04	8	315526	14575	79414279
Petechiae	33.31	18.04	20	315514	20545	79408309
Headache	33.30	18.04	3011	312523	650761	78778093
Mouth ulceration	33.28	18.04	263	315271	38131	79390723
Multiple allergies	33.22	18.04	104	315430	10356	79418498
Left ventricular hypertrophy	33.21	18.04	3	315531	11188	79417666
Shoulder arthroplasty	33.13	18.04	52	315482	3230	79425624
Device occlusion	33.10	18.04	4	315530	11862	79416992
Drug specific antibody present	33.06	18.04	78	315456	6574	79422280
Post procedural haemorrhage	33.04	18.04	7	315527	13737	79415117
Diverticulum	33.03	18.04	9	315525	14887	79413967
Eye disorder	32.89	18.04	181	315353	23231	79405623
Pulseless electrical activity	32.46	18.04	8	315526	14152	79414702
Fistula	32.34	18.04	6	315528	12934	79415920
Psoriasis	32.26	18.04	516	315018	89071	79339783
Intervertebral disc space narrowing	32.19	18.04	37	315497	1698	79427156
Product temperature excursion issue	32.15	18.04	17	315517	236	79428618
Aspergillus infection	31.94	18.04	18	315516	19143	79409711
Soft tissue disorder	31.82	18.04	53	315481	3462	79425392
Diastolic dysfunction	31.81	18.04	3	315531	10808	79418046
Systemic inflammatory response syndrome	31.65	18.04	4	315530	11461	79417393
Graft versus host disease	31.63	18.04	10	315524	15016	79413838
Dysstasia	31.48	18.04	38	315496	27708	79401146
Abnormal dreams	31.46	18.04	4	315530	11408	79417446
Intestinal ischaemia	31.41	18.04	7	315527	13263	79415591
Pulmonary toxicity	31.03	18.04	117	315417	12797	79416057
Renal disorder	30.96	18.04	76	315458	42029	79386825
Injection site warmth	30.91	18.04	10	315524	14797	79414057
Alanine aminotransferase increased	30.77	18.04	455	315079	162115	79266739
Coronary artery stenosis	30.75	18.04	6	315528	12478	79416376
Respiratory acidosis	30.70	18.04	4	315530	11196	79417658
Cerebral ischaemia	30.68	18.04	4	315530	11191	79417663
Failure to thrive	30.68	18.04	5	315529	11839	79417015
Apathy	30.40	18.04	7	315527	12970	79415884
Nervous system disorder	30.24	18.04	37	315497	26819	79402035
Bone density abnormal	30.22	18.04	48	315486	3012	79425842
Haemorrhagic stroke	30.15	18.04	4	315530	11042	79417812
Upper-airway cough syndrome	30.15	18.04	5	315529	11688	79417166
Body temperature increased	30.01	18.04	288	315246	44132	79384722
Rash pruritic	29.84	18.04	423	315111	71206	79357648
Angina unstable	29.82	18.04	14	315520	16513	79412341
Polyneuropathy	29.67	18.04	31	315503	24120	79404734
Nerve injury	29.48	18.04	93	315441	9299	79419555
C-reactive protein decreased	29.37	18.04	44	315490	2624	79426230
Product quality issue	29.32	18.04	56	315478	33884	79394970
Therapeutic response shortened	29.30	18.04	13	315521	15850	79413004
Immune thrombocytopenia	29.29	18.04	17	315517	17788	79411066
Skin papilloma	29.23	18.04	69	315465	5817	79423037
Granulocytopenia	29.22	18.04	5	315529	11426	79417428
Skin plaque	29.06	18.04	4	315530	10741	79418113
Cholecystitis	29.03	18.04	27	315507	22185	79406669
Acute pulmonary oedema	29.03	18.04	10	315524	14220	79414634
Increased appetite	29.00	18.04	6	315528	11972	79416882
Injury	28.90	18.04	449	315085	77047	79351807
Caesarean section	28.90	18.04	7	315527	12528	79416326
Haemorrhoids	28.89	18.04	44	315490	29084	79399770
Cartilage atrophy	28.86	18.04	14	315520	160	79428694
Hepatitis C	28.81	18.04	6	315528	11919	79416935
Neoplasm malignant	28.73	18.04	220	315314	31590	79397264
Hypertensive crisis	28.65	18.04	24	315510	20746	79408108
Malignant melanoma	28.62	18.04	125	315409	14616	79414238
Hepatitis B reactivation	28.61	18.04	70	315464	6038	79422816
Sensory loss	28.52	18.04	8	315526	12983	79415871
Bacterial infection	28.46	18.04	50	315484	31230	79397624
Hot flush	28.43	18.04	116	315418	54761	79374093
Vasculitic rash	28.42	18.04	39	315495	2145	79426709
Congestive cardiomyopathy	28.31	18.04	6	315528	11774	79417080
Muscle tightness	28.27	18.04	8	315526	12906	79415948
COVID-19 pneumonia	28.21	18.04	44	315490	28805	79400049
Cardiac failure chronic	28.18	18.04	5	315529	11130	79417724
Progressive multifocal leukoencephalopathy	28.17	18.04	24	315510	20576	79408278
Eye pruritus	28.09	18.04	24	315510	20546	79408308
Tooth infection	28.08	18.04	148	315386	18684	79410170
General physical health deterioration	28.06	18.04	1345	314189	273893	79154961
Hypovolaemic shock	28.02	18.04	7	315527	12269	79416585
Drug level below therapeutic	27.99	18.04	3	315531	9767	79419087
Viral upper respiratory tract infection	27.98	18.04	89	315445	8937	79419917
Abortion spontaneous	27.92	18.04	46	315488	29461	79399393
Eyelid ptosis	27.86	18.04	5	315529	11039	79417815
Walking aid user	27.84	18.04	96	315438	10052	79418802
Myasthenia gravis	27.83	18.04	4	315530	10395	79418459
Prostatic specific antigen increased	27.78	18.04	4	315530	10382	79418472
Temperature intolerance	27.75	18.04	3	315531	9702	79419152
Rheumatoid factor	27.51	18.04	18	315516	378	79428476
Appendicitis	27.50	18.04	25	315509	20769	79408085
Sleep disorder due to a general medical condition	27.50	18.04	11	315523	14266	79414588
Tooth disorder	27.48	18.04	188	315346	26045	79402809
Facial paralysis	27.09	18.04	26	315508	21046	79407808
Necrosis	26.98	18.04	3	315531	9490	79419364
Infusion site erythema	26.86	18.04	3	315531	9457	79419397
Large intestine perforation	26.81	18.04	12	315522	14555	79414299
Injection site swelling	26.76	18.04	96	315438	47036	79381818
Spinal fusion surgery	26.67	18.04	62	315472	5176	79423678
Cholecystitis acute	26.51	18.04	10	315524	13441	79415413
Antibody test positive	26.49	18.04	43	315491	2749	79426105
Proctalgia	26.41	18.04	4	315530	9997	79418857
Bladder cancer	26.40	18.04	23	315511	19503	79409351
Overlap syndrome	26.39	18.04	26	315508	998	79427856
Precancerous cells present	26.30	18.04	28	315506	1179	79427675
Emotional disorder	26.25	18.04	12	315522	14375	79414479
Respiratory rate increased	26.23	18.04	28	315506	21572	79407282
Deafness neurosensory	26.11	18.04	73	315461	6825	79422029
Throat tightness	25.94	18.04	44	315490	27863	79400991
Oesophageal carcinoma	25.93	18.04	6	315528	11078	79417776
Multiple sclerosis	25.83	18.04	30	315504	22252	79406602
Metabolic disorder	25.81	18.04	3	315531	9167	79419687
Staphylococcal sepsis	25.77	18.04	13	315521	14713	79414141
Dermatitis contact	25.75	18.04	6	315528	11027	79417827
Lung disorder	25.71	18.04	455	315079	80102	79348752
Mean cell volume decreased	25.67	18.04	59	315475	4888	79423966
Paralysis	25.63	18.04	10	315524	13167	79415687
Blood calcium increased	25.61	18.04	5	315529	10395	79418459
Off label use	25.58	18.04	4024	311510	903191	78525663
Pulmonary alveolar haemorrhage	25.26	18.04	7	315527	11450	79417404
Tendon disorder	25.22	18.04	74	315460	7112	79421742
Head discomfort	25.08	18.04	13	315521	14489	79414365
Lung consolidation	25.00	18.04	3	315531	8944	79419910
Injection site mass	24.69	18.04	26	315508	20158	79408696
Mean cell haemoglobin decreased	24.69	18.04	67	315467	6157	79422697
Lupus vulgaris	24.53	18.04	46	315488	3300	79425554
Muscle atrophy	24.51	18.04	7	315527	11225	79417629
Eye pain	24.49	18.04	72	315462	37506	79391348
Neck pain	24.44	18.04	427	315107	74990	79353864
Fungal infection	24.39	18.04	84	315450	41664	79387190
Ankle fracture	24.38	18.04	132	315402	16837	79412017
Cholangitis	24.35	18.04	10	315524	12766	79416088
Hiccups	24.33	18.04	5	315529	10026	79418828
Blood pressure diastolic abnormal	24.33	18.04	24	315510	19178	79409676
Stress cardiomyopathy	24.29	18.04	7	315527	11159	79417695
Lacrimation increased	24.23	18.04	32	315502	22445	79406409
Hepatic enzyme abnormal	24.20	18.04	77	315457	7733	79421121
Product label confusion	24.18	18.04	31	315503	1595	79427259
Interstitial lung disease	24.16	18.04	600	314934	112000	79316854
Blood glucose abnormal	24.16	18.04	6	315528	10560	79418294
Eyelid oedema	24.08	18.04	12	315522	13675	79415179
Benign prostatic hyperplasia	23.97	18.04	8	315526	11604	79417250
Gout	23.96	18.04	38	315496	24711	79404143
Nephrolithiasis	23.94	18.04	319	315215	52972	79375882
Hypokinesia	23.94	18.04	24	315510	19036	79409818
Colorectal cancer	23.91	18.04	3	315531	8644	79420210
Short stature	23.88	18.04	21	315513	696	79428158
Faecaloma	23.81	18.04	8	315526	11556	79417298
Uterine disorder	23.73	18.04	36	315498	2171	79426683
Bronchitis	23.69	18.04	681	314853	129963	79298891
Incorrect product administration duration	23.59	18.04	9	315525	12013	79416841
Food intolerance	23.50	18.04	49	315485	3799	79425055
Cystitis haemorrhagic	23.47	18.04	4	315530	9168	79419686
Metabolic encephalopathy	23.38	18.04	4	315530	9143	79419711
Nephropathy	23.32	18.04	5	315529	9733	79419121
Pregnancy	23.31	18.04	184	315350	26667	79402187
Hypertransaminasaemia	23.27	18.04	9	315525	11915	79416939
Protein total decreased	23.19	18.04	4	315530	9088	79419766
Kidney infection	23.13	18.04	157	315377	21694	79407160
Hydronephrosis	23.07	18.04	21	315513	17433	79411421
Lower gastrointestinal haemorrhage	23.03	18.04	18	315516	16107	79412747
Pruritus allergic	22.93	18.04	28	315506	1371	79427483
Personality change	22.82	18.04	6	315528	10164	79418690
Dementia	22.81	18.04	39	315495	24620	79404234
Major depression	22.80	18.04	4	315530	8976	79419878
Diabetes mellitus inadequate control	22.79	18.04	38	315496	24226	79404628
Rhinitis allergic	22.75	18.04	10	315524	12259	79416595
Muscle strain	22.69	18.04	5	315529	9550	79419304
Poor venous access	22.67	18.04	136	315398	18013	79410841
Unevaluable event	22.66	18.04	128	315406	55457	79373397
Extremity contracture	22.64	18.04	31	315503	1701	79427153
Aortic valve incompetence	22.61	18.04	5	315529	9525	79419329
Staphylococcal bacteraemia	22.59	18.04	10	315524	12208	79416646
Azotaemia	22.58	18.04	3	315531	8273	79420581
Endocarditis	22.40	18.04	7	315527	10590	79418264
Retinal haemorrhage	22.37	18.04	3	315531	8214	79420640
Peripheral ischaemia	22.36	18.04	5	315529	9452	79419402
Sneezing	22.28	18.04	27	315507	19656	79409198
Localised infection	22.20	18.04	237	315297	37338	79391516
Heavy menstrual bleeding	22.18	18.04	14	315520	13997	79414857
Ear infection	22.16	18.04	221	315313	34211	79394643
Spinal meningioma benign	22.13	18.04	10	315524	96	79428758
Body temperature decreased	22.12	18.04	60	315474	32085	79396769
Accident	22.05	18.04	81	315453	8750	79420104
Fear	22.01	18.04	33	315501	21953	79406901
Brain injury	21.97	18.04	9	315525	11508	79417346
Nodular regenerative hyperplasia	21.92	18.04	27	315507	1334	79427520
Ischaemia	21.86	18.04	3	315531	8072	79420782
Skin haemorrhage	21.85	18.04	10	315524	11971	79416883
Device leakage	21.80	18.04	93	315441	10763	79418091
Lesion excision	21.78	18.04	11	315523	138	79428716
Fibrin D dimer increased	21.66	18.04	4	315530	8650	79420204
Renal cyst	21.61	18.04	16	315518	14716	79414138
Cyst	21.49	18.04	110	315424	13730	79415124
Duodenitis	21.47	18.04	3	315531	7964	79420890
Infusion site pain	21.31	18.04	15	315519	14161	79414693
Autoimmune hepatitis	21.23	18.04	10	315524	11773	79417081
Device breakage	20.93	18.04	8	315526	10667	79418187
Joint lock	20.80	18.04	42	315492	3183	79425671
Injection related reaction	20.77	18.04	23	315511	1013	79427841
Intestinal perforation	20.70	18.04	23	315511	17403	79411451
Dermatitis atopic	20.63	18.04	7	315527	10049	79418805
Allergy to chemicals	20.63	18.04	37	315497	2565	79426289
Incoherent	20.49	18.04	3	315531	7689	79421165
Sputum discoloured	20.47	18.04	34	315500	21709	79407145
Acute graft versus host disease in skin	20.37	18.04	3	315531	7655	79421199
Post transplant lymphoproliferative disorder	20.24	18.04	10	315524	11454	79417400
BK virus infection	20.13	18.04	5	315529	8799	79420055
Thrombosis	20.13	18.04	224	315310	83876	79344978
Nerve block	20.06	18.04	19	315515	694	79428160
Metastases to lymph nodes	20.04	18.04	8	315526	10389	79418465
Blindness unilateral	19.89	18.04	4	315530	8142	79420712
Rash pustular	19.77	18.04	10	315524	11301	79417553
Glucose tolerance impaired	19.67	18.04	4	315530	8080	79420774
Cerebral atrophy	19.64	18.04	4	315530	8071	79420783
Peripheral vascular disorder	19.49	18.04	4	315530	8026	79420828
Lymphoma	19.41	18.04	127	315407	17333	79411521
Skin disorder	19.36	18.04	69	315465	33874	79394980
Blood test abnormal	19.31	18.04	25	315509	17685	79411169
Atrioventricular block second degree	19.13	18.04	3	315531	7309	79421545
Skin hyperpigmentation	19.10	18.04	3	315531	7300	79421554
Visual field defect	19.08	18.04	6	315528	9039	79419815
Cachexia	19.07	18.04	10	315524	11073	79417781
Rheumatic disorder	19.04	18.04	40	315494	3118	79425736
Neuralgia	18.95	18.04	68	315466	33316	79395538
Ketoacidosis	18.88	18.04	4	315530	7850	79421004
Extra dose administered	18.82	18.04	5	315529	8410	79420444
Infusion site swelling	18.78	18.04	4	315530	7822	79421032
Cataract operation	18.78	18.04	54	315480	5131	79423723
Hypoxic-ischaemic encephalopathy	18.76	18.04	4	315530	7816	79421038
Paronychia	18.72	18.04	4	315530	7804	79421050
Amyotrophic lateral sclerosis	18.66	18.04	29	315505	1786	79427068
Facial pain	18.66	18.04	13	315521	12337	79416517
Disseminated large cell lymphoma	18.65	18.04	8	315526	67	79428787
Keratitis	18.64	18.04	48	315486	4274	79424580
Diarrhoea haemorrhagic	18.61	18.04	15	315519	13219	79415635
Neck surgery	18.61	18.04	29	315505	1790	79427064
Enterocolitis	18.54	18.04	18	315516	14494	79414360
Device use error	18.39	18.04	3	315531	7098	79421756
Injection site induration	18.21	18.04	8	315526	9811	79419043
Psychiatric symptom	18.15	18.04	3	315531	7032	79421822
Vaginal prolapse repair	18.15	18.04	4	315530	0	79428854
Pulmonary function test decreased	18.13	18.04	4	315530	7633	79421221
Ventricular hypokinesia	18.12	18.04	7	315527	9272	79419582

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

Source	Code	Description
ATC	L04AA24	ANTINEOPLASTIC AND IMMUNOMODULATING AGENTS IMMUNOSUPPRESSANTS IMMUNOSUPPRESSANTS Selective immunosuppressants
FDA CS	M0018640	Recombinant Fusion Proteins
FDA PE	N0000008571	Decreased Cytokine Activity
MeSH PA	D000970	Antineoplastic Agents
MeSH PA	D000074322	Antineoplastic Agents, Immunological
MeSH PA	D018501	Antirheumatic Agents
MeSH PA	D000082082	Immune Checkpoint Inhibitors
MeSH PA	D007155	Immunologic Factors
MeSH PA	D007166	Immunosuppressive Agents
FDA EPC	N0000182159	Selective T Cell Costimulation Modulator

Drug Use | Suggest Off label Use Form| |View source of the data|

Disease	Relation	SNOMED_ID	DOID
Rheumatoid arthritis	indication	69896004	DOID:7148
Juvenile idiopathic arthritis	indication	410502007

🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

None

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

Target	Class	Pharos	UniProt	Action	Type	Activity value (-log[M])	Mechanism action	Bioact source	MoA source
T-lymphocyte activation antigen CD80	Surface antigen	P33681	CD80_HUMAN	INHIBITOR	Kd	7.92		IUPHAR	DRUG LABEL
T-lymphocyte activation antigen CD86	Surface antigen	P42081	CD86_HUMAN	INHIBITOR	Kd	7.92		IUPHAR	DRUG LABEL

External reference:

ID	Source
7D0YB67S97	UNII
D03203	KEGG_DRUG
4025085	VANDF
C1619966	UMLSCUI
CHEMBL1201823	ChEMBL_ID
DB01281	DRUGBANK_ID
D000069594	MESH_DESCRIPTOR_UI
8495	INN_ID
6891	IUPHAR_LIGAND_ID
614391	RXNORM
20795	MMSL
73627	MMSL
d05694	MMSL
011175	NDDF
421412005	SNOMEDCT_US
421777009	SNOMEDCT_US

Pharmaceutical products:

Product	Category	Ingredients	NDC	Form	Quantity	Route	Marketing	Label
ORENCIA	HUMAN PRESCRIPTION DRUG LABEL	1	0003-2187	INJECTION, POWDER, LYOPHILIZED, FOR SOLUTION	250 mg	INTRAVENOUS	BLA	30 sections
ORENCIA	HUMAN PRESCRIPTION DRUG LABEL	1	0003-2187	INJECTION, POWDER, LYOPHILIZED, FOR SOLUTION	250 mg	INTRAVENOUS	BLA	30 sections
ORENCIA	HUMAN PRESCRIPTION DRUG LABEL	1	0003-2187	INJECTION, POWDER, LYOPHILIZED, FOR SOLUTION	250 mg	INTRAVENOUS	BLA	30 sections
ORENCIA	HUMAN PRESCRIPTION DRUG LABEL	1	0003-2188	INJECTION, SOLUTION	125 mg	SUBCUTANEOUS	BLA	30 sections
ORENCIA	HUMAN PRESCRIPTION DRUG LABEL	1	0003-2188	INJECTION, SOLUTION	125 mg	SUBCUTANEOUS	BLA	30 sections
ORENCIA	HUMAN PRESCRIPTION DRUG LABEL	1	0003-2188	INJECTION, SOLUTION	125 mg	SUBCUTANEOUS	BLA	30 sections
ORENCIA	HUMAN PRESCRIPTION DRUG LABEL	1	0003-2814	INJECTION, SOLUTION	50 mg	SUBCUTANEOUS	BLA	30 sections
ORENCIA	HUMAN PRESCRIPTION DRUG LABEL	1	0003-2814	INJECTION, SOLUTION	50 mg	SUBCUTANEOUS	BLA	30 sections
ORENCIA	HUMAN PRESCRIPTION DRUG LABEL	1	0003-2814	INJECTION, SOLUTION	50 mg	SUBCUTANEOUS	BLA	30 sections
ORENCIA	HUMAN PRESCRIPTION DRUG LABEL	1	0003-2818	INJECTION, SOLUTION	87.50 mg	SUBCUTANEOUS	BLA	30 sections
ORENCIA	HUMAN PRESCRIPTION DRUG LABEL	1	0003-2818	INJECTION, SOLUTION	87.50 mg	SUBCUTANEOUS	BLA	30 sections
ORENCIA	HUMAN PRESCRIPTION DRUG LABEL	1	0003-2818	INJECTION, SOLUTION	87.50 mg	SUBCUTANEOUS	BLA	30 sections