gusperimus 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
immunosuppressants (other than antineoplastics) 1347 98629-43-7

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • deoxyspergualin
  • gusperimus hydrochloride
  • gusperimus trihydrochloride
  • gusperimus
  • (+/-)-Deoxyspergualin
  • gusperimus HCl
synthesized by chemical modification of spergualin; in combination with cyclosporin A prevents diabetes in predisposed NOD mice; structure given in first source; RN given refers to (-)-isomer trihydrochloride
  • Molecular weight: 387.53
  • Formula: C17H37N7O3
  • CLOGP: -0.09
  • LIPINSKI: 1
  • HAC: 10
  • HDO: 8
  • TPSA: 178.38
  • ALOGS: -3.48
  • ROTB: 17

Drug dosage:

None

ADMET properties:

None

Approvals:

None

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

None

FDA Adverse Event Reporting System (Geriatric)

None

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
ATC L04AA19 ANTINEOPLASTIC AND IMMUNOMODULATING AGENTS
IMMUNOSUPPRESSANTS
IMMUNOSUPPRESSANTS
Selective immunosuppressants
MeSH PA D000903 Antibiotics, Antineoplastic
MeSH PA D000970 Antineoplastic Agents
MeSH PA D007004 Hypoglycemic Agents
MeSH PA D007155 Immunologic Factors
MeSH PA D007166 Immunosuppressive Agents
MeSH PA D020011 Protective Agents
MeSH PA D011837 Radiation-Protective Agents

Drug Use (View source of the data)

None




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 12.9 acidic
pKa2 13.96 acidic
pKa3 10.25 Basic
pKa4 9.6 Basic
pKa5 8.52 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

None

External reference:

IDSource
D01566 KEGG_DRUG
89149-10-0 SECONDARY_CAS_RN
85468-01-5 SECONDARY_CAS_RN
C0284559 UMLSCUI
CHEBI:135609 CHEBI
CHEMBL406117 ChEMBL_ID
CHEMBL2356648 ChEMBL_ID
CHEMBL1996913 ChEMBL_ID
DB12692 DRUGBANK_ID
C037258 MESH_SUPPLEMENTAL_RECORD_UI
55362 PUBCHEM_CID
6941 INN_ID
UJ0ZJ76DO9 UNII
DB12991 DRUGBANK_ID

Pharmaceutical products:

None