Stem definition | Drug id | CAS RN |
---|---|---|
phosphodiesterase IV (PDE IV) inhibitors | 4829 | 608141-41-9 |
Dose | Unit | Route |
---|---|---|
60 | mg | O |
Property | Value | Reference |
---|---|---|
CL (Clearance) | 2.38 mL/min/kg | Lombardo F, Berellini G, Obach RS |
fu (Fraction unbound in plasma) | 0.32 % | Lombardo F, Berellini G, Obach RS |
t_half (Half-life) | 6.03 hours | Lombardo F, Berellini G, Obach RS |
Date | Agency | Company | Orphan |
---|---|---|---|
Sept. 20, 2019 | PMDA | Celgene K.K. | |
March 21, 2014 | FDA | CELGENE CORP | |
Nov. 20, 2014 | EMA |
MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
---|---|---|---|---|---|---|
Psoriasis | 18840.35 | 26.16 | 7084 | 107601 | 71520 | 46499857 |
Diarrhoea | 10405.22 | 26.16 | 9434 | 105251 | 550168 | 46021209 |
Nausea | 8890.80 | 26.16 | 9509 | 105176 | 677945 | 45893432 |
Headache | 6846.76 | 26.16 | 7015 | 107670 | 471337 | 46100040 |
Product dose omission issue | 5603.74 | 26.16 | 4026 | 110659 | 164494 | 46406883 |
Psoriatic arthropathy | 4853.71 | 26.16 | 2168 | 112517 | 34211 | 46537166 |
Abdominal discomfort | 2545.71 | 26.16 | 2441 | 112244 | 148724 | 46422653 |
Drug ineffective | 1773.73 | 26.16 | 4596 | 110089 | 673242 | 45898135 |
Adverse drug reaction | 1302.46 | 26.16 | 988 | 113697 | 43374 | 46528003 |
Depression | 1147.55 | 26.16 | 1726 | 112959 | 168378 | 46402999 |
Therapy non-responder | 800.23 | 26.16 | 722 | 113963 | 40430 | 46530947 |
Abdominal pain upper | 751.58 | 26.16 | 1308 | 113377 | 143997 | 46427380 |
Weight decreased | 726.56 | 26.16 | 1599 | 113086 | 209250 | 46362127 |
Gastric disorder | 600.33 | 26.16 | 509 | 114176 | 26196 | 46545181 |
Frequent bowel movements | 558.82 | 26.16 | 362 | 114323 | 12270 | 46559107 |
Migraine | 550.14 | 26.16 | 765 | 113920 | 69261 | 46502116 |
Acute kidney injury | 542.90 | 26.16 | 7 | 114678 | 235848 | 46335529 |
Toxicity to various agents | 475.84 | 26.16 | 9 | 114676 | 211757 | 46359620 |
Dyspnoea | 463.60 | 26.16 | 355 | 114330 | 515193 | 46056184 |
Anaemia | 431.18 | 26.16 | 59 | 114626 | 255720 | 46315657 |
Hypotension | 395.91 | 26.16 | 52 | 114633 | 232537 | 46338840 |
Rash | 382.90 | 26.16 | 1809 | 112876 | 354703 | 46216674 |
Drug interaction | 366.58 | 26.16 | 37 | 114648 | 203057 | 46368320 |
Dyspepsia | 355.30 | 26.16 | 618 | 114067 | 67854 | 46503523 |
Pyrexia | 338.14 | 26.16 | 221 | 114464 | 348581 | 46222796 |
Neutropenia | 326.04 | 26.16 | 5 | 114680 | 143199 | 46428178 |
Tension headache | 322.78 | 26.16 | 149 | 114536 | 2525 | 46568852 |
Thrombocytopenia | 285.71 | 26.16 | 5 | 114680 | 126576 | 46444801 |
Vomiting | 275.09 | 26.16 | 1976 | 112709 | 450818 | 46120559 |
Stress | 273.52 | 26.16 | 470 | 114215 | 51081 | 46520296 |
Gastrointestinal disorder | 261.20 | 26.16 | 500 | 114185 | 59076 | 46512301 |
Confusional state | 255.19 | 26.16 | 43 | 114642 | 159849 | 46411528 |
Insomnia | 236.72 | 26.16 | 915 | 113770 | 164009 | 46407368 |
Haemoglobin decreased | 236.47 | 26.16 | 22 | 114663 | 128927 | 46442450 |
Oedema peripheral | 220.14 | 26.16 | 60 | 114625 | 159646 | 46411731 |
Exposure during pregnancy | 220.07 | 26.16 | 11 | 114674 | 108201 | 46463176 |
Faeces soft | 217.31 | 26.16 | 124 | 114561 | 3324 | 46568053 |
Overdose | 211.83 | 26.16 | 9 | 114676 | 101970 | 46469407 |
Therapeutic response decreased | 210.24 | 26.16 | 379 | 114306 | 42766 | 46528611 |
White blood cell count decreased | 206.16 | 26.16 | 19 | 114666 | 112212 | 46459165 |
Upper respiratory tract infection | 202.32 | 26.16 | 468 | 114217 | 63088 | 46508289 |
Fall | 199.50 | 26.16 | 313 | 114372 | 328784 | 46242593 |
Death | 198.84 | 26.16 | 324 | 114361 | 335224 | 46236153 |
Therapeutic product effect decreased | 195.90 | 26.16 | 544 | 114141 | 82057 | 46489320 |
Cardiac arrest | 194.60 | 26.16 | 6 | 114679 | 90393 | 46480984 |
Pancytopenia | 193.40 | 26.16 | 3 | 114682 | 85055 | 46486322 |
Pneumonia | 193.09 | 26.16 | 397 | 114288 | 375923 | 46195454 |
Pleural effusion | 188.29 | 26.16 | 3 | 114682 | 82949 | 46488428 |
Sepsis | 185.74 | 26.16 | 52 | 114633 | 135962 | 46435415 |
Seizure | 181.69 | 26.16 | 40 | 114645 | 123014 | 46448363 |
Respiratory failure | 176.99 | 26.16 | 15 | 114670 | 94801 | 46476576 |
Platelet count decreased | 175.76 | 26.16 | 20 | 114665 | 100004 | 46471373 |
Asthenia | 174.48 | 26.16 | 311 | 114374 | 310764 | 46260613 |
Maternal exposure during pregnancy | 167.09 | 26.16 | 26 | 114659 | 102523 | 46468854 |
Pulmonary embolism | 160.89 | 26.16 | 35 | 114650 | 108550 | 46462827 |
Renal failure | 155.87 | 26.16 | 43 | 114642 | 113551 | 46457826 |
Disease progression | 151.38 | 26.16 | 22 | 114663 | 91278 | 46480099 |
Loss of consciousness | 150.34 | 26.16 | 40 | 114645 | 108198 | 46463179 |
Enthesopathy | 149.76 | 26.16 | 110 | 114575 | 4580 | 46566797 |
Leukopenia | 145.43 | 26.16 | 5 | 114680 | 68338 | 46503039 |
Arthralgia | 144.59 | 26.16 | 1448 | 113237 | 363155 | 46208222 |
Deep vein thrombosis | 142.56 | 26.16 | 15 | 114670 | 79758 | 46491619 |
Intentional overdose | 140.90 | 26.16 | 4 | 114681 | 64940 | 46506437 |
Malignant neoplasm progression | 140.85 | 26.16 | 4 | 114681 | 64922 | 46506455 |
Syncope | 139.50 | 26.16 | 42 | 114643 | 104761 | 46466616 |
Product supply issue | 138.40 | 26.16 | 59 | 114626 | 819 | 46570558 |
Oxygen saturation decreased | 137.57 | 26.16 | 8 | 114677 | 69156 | 46502221 |
Drug hypersensitivity | 135.49 | 26.16 | 245 | 114440 | 243580 | 46327797 |
Decreased appetite | 130.01 | 26.16 | 868 | 113817 | 192968 | 46378409 |
Coma | 128.82 | 26.16 | 3 | 114682 | 58346 | 46513031 |
Unevaluable event | 128.63 | 26.16 | 323 | 114362 | 45852 | 46525525 |
Tachycardia | 125.40 | 26.16 | 44 | 114641 | 99578 | 46471799 |
Injection site pain | 122.30 | 26.16 | 55 | 114630 | 107097 | 46464280 |
Cardiac failure | 119.99 | 26.16 | 25 | 114660 | 79923 | 46491454 |
Off label use | 119.47 | 26.16 | 504 | 114181 | 379337 | 46192040 |
Injection site erythema | 118.69 | 26.16 | 20 | 114665 | 74407 | 46496970 |
Somnolence | 114.90 | 26.16 | 129 | 114556 | 156392 | 46414985 |
Cardiac failure congestive | 114.66 | 26.16 | 41 | 114644 | 91709 | 46479668 |
Hypoxia | 113.16 | 26.16 | 3 | 114682 | 51835 | 46519542 |
Chest pain | 113.13 | 26.16 | 161 | 114524 | 176163 | 46395214 |
Multiple organ dysfunction syndrome | 112.86 | 26.16 | 3 | 114682 | 51707 | 46519670 |
Septic shock | 111.27 | 26.16 | 8 | 114677 | 57885 | 46513492 |
Hyperkalaemia | 110.45 | 26.16 | 3 | 114682 | 50706 | 46520671 |
Product use in unapproved indication | 110.01 | 26.16 | 42 | 114643 | 90231 | 46481146 |
Pruritus | 109.00 | 26.16 | 989 | 113696 | 241363 | 46330014 |
Flatulence | 108.08 | 26.16 | 227 | 114458 | 28651 | 46542726 |
Therapeutic product effect incomplete | 104.96 | 26.16 | 425 | 114260 | 77728 | 46493649 |
Infusion related reaction | 104.91 | 26.16 | 59 | 114626 | 101149 | 46470228 |
Gastrointestinal haemorrhage | 101.16 | 26.16 | 32 | 114653 | 77341 | 46494036 |
Dehydration | 101.03 | 26.16 | 147 | 114538 | 159393 | 46411984 |
Oedema | 100.59 | 26.16 | 21 | 114664 | 67050 | 46504327 |
Hypoglycaemia | 100.30 | 26.16 | 9 | 114676 | 54340 | 46517037 |
Atrial fibrillation | 98.21 | 26.16 | 67 | 114618 | 103523 | 46467854 |
Neuropathy peripheral | 97.10 | 26.16 | 51 | 114634 | 90842 | 46480535 |
Plasma cell myeloma | 95.53 | 26.16 | 3 | 114682 | 44475 | 46526902 |
Interstitial lung disease | 89.41 | 26.16 | 13 | 114672 | 53936 | 46517441 |
Mood altered | 87.25 | 26.16 | 132 | 114553 | 12875 | 46558502 |
Pulmonary oedema | 85.42 | 26.16 | 12 | 114673 | 51093 | 46520284 |
Hypertension | 84.54 | 26.16 | 227 | 114458 | 196129 | 46375248 |
Blood alkaline phosphatase increased | 83.90 | 26.16 | 3 | 114682 | 39606 | 46531771 |
Mucosal inflammation | 82.39 | 26.16 | 3 | 114682 | 38973 | 46532404 |
Anaphylactic reaction | 80.95 | 26.16 | 16 | 114669 | 53096 | 46518281 |
Dysphagia | 80.21 | 26.16 | 45 | 114640 | 77267 | 46494110 |
Rebound psoriasis | 79.78 | 26.16 | 21 | 114664 | 50 | 46571327 |
Nasopharyngitis | 79.38 | 26.16 | 648 | 114037 | 153350 | 46418027 |
Tenosynovitis | 79.12 | 26.16 | 95 | 114590 | 7420 | 46563957 |
Alanine aminotransferase increased | 78.90 | 26.16 | 61 | 114624 | 88390 | 46482987 |
Muscle spasms | 78.66 | 26.16 | 545 | 114140 | 122568 | 46448809 |
Product use issue | 78.58 | 26.16 | 70 | 114615 | 94574 | 46476803 |
Delirium | 78.23 | 26.16 | 3 | 114682 | 37225 | 46534152 |
Ascites | 76.70 | 26.16 | 3 | 114682 | 36581 | 46534796 |
Pulmonary hypertension | 75.30 | 26.16 | 3 | 114682 | 35990 | 46535387 |
Mental status changes | 73.95 | 26.16 | 5 | 114680 | 38083 | 46533294 |
Weight increased | 70.88 | 26.16 | 190 | 114495 | 164283 | 46407094 |
Pemphigus | 70.35 | 26.16 | 13 | 114672 | 45261 | 46526116 |
Hyperglycaemia | 69.90 | 26.16 | 4 | 114681 | 35067 | 46536310 |
Muscular weakness | 69.22 | 26.16 | 74 | 114611 | 91770 | 46479607 |
Blood creatinine increased | 69.02 | 26.16 | 52 | 114633 | 76351 | 46495026 |
Liver function test abnormal | 68.79 | 26.16 | 15 | 114670 | 46472 | 46524905 |
Paraesthesia | 67.85 | 26.16 | 115 | 114570 | 117322 | 46454055 |
Dysarthria | 67.11 | 26.16 | 7 | 114678 | 37491 | 46533886 |
Cerebrovascular accident | 67.01 | 26.16 | 90 | 114595 | 100949 | 46470428 |
Balance disorder | 66.29 | 26.16 | 38 | 114647 | 64483 | 46506894 |
Dyspnoea exertional | 65.37 | 26.16 | 21 | 114664 | 50268 | 46521109 |
Pneumonia aspiration | 64.90 | 26.16 | 3 | 114682 | 31602 | 46539775 |
Influenza | 64.76 | 26.16 | 408 | 114277 | 88862 | 46482515 |
Aspartate aminotransferase increased | 64.38 | 26.16 | 59 | 114626 | 78641 | 46492736 |
Blood pressure decreased | 64.16 | 26.16 | 30 | 114655 | 57129 | 46514248 |
Coronary artery disease | 63.90 | 26.16 | 5 | 114680 | 33747 | 46537630 |
Injury | 63.56 | 26.16 | 15 | 114670 | 44012 | 46527365 |
Multiple sclerosis relapse | 63.55 | 26.16 | 13 | 114672 | 42112 | 46529265 |
Injection site pruritus | 62.65 | 26.16 | 11 | 114674 | 39732 | 46531645 |
Flushing | 62.29 | 26.16 | 41 | 114644 | 64573 | 46506804 |
Systemic lupus erythematosus | 61.97 | 26.16 | 42 | 114643 | 65138 | 46506239 |
Femur fracture | 61.10 | 26.16 | 9 | 114676 | 36988 | 46534389 |
Chronic kidney disease | 60.86 | 26.16 | 13 | 114672 | 40858 | 46530519 |
Hepatic failure | 60.42 | 26.16 | 6 | 114679 | 33410 | 46537967 |
Injection site swelling | 59.70 | 26.16 | 13 | 114672 | 40314 | 46531063 |
Respiratory distress | 59.66 | 26.16 | 5 | 114680 | 31911 | 46539466 |
Hallucination | 59.59 | 26.16 | 24 | 114661 | 49927 | 46521450 |
Acute respiratory failure | 59.08 | 26.16 | 3 | 114682 | 29135 | 46542242 |
Myocardial infarction | 58.67 | 26.16 | 93 | 114592 | 97435 | 46473942 |
Glossodynia | 58.62 | 26.16 | 18 | 114667 | 44355 | 46527022 |
Dyskinesia | 58.58 | 26.16 | 3 | 114682 | 28922 | 46542455 |
Renal impairment | 58.22 | 26.16 | 58 | 114627 | 74314 | 46497063 |
Angioedema | 57.60 | 26.16 | 13 | 114672 | 39329 | 46532048 |
Adverse reaction | 56.97 | 26.16 | 84 | 114601 | 8006 | 46563371 |
Cognitive disorder | 56.44 | 26.16 | 11 | 114674 | 36872 | 46534505 |
Thrombosis | 56.22 | 26.16 | 34 | 114651 | 56035 | 46515342 |
Vision blurred | 55.96 | 26.16 | 68 | 114617 | 79640 | 46491737 |
Intentional product use issue | 55.79 | 26.16 | 30 | 114655 | 52750 | 46518627 |
Fluid retention | 55.46 | 26.16 | 28 | 114657 | 51018 | 46520359 |
Hepatitis | 55.18 | 26.16 | 7 | 114678 | 32208 | 46539169 |
No adverse event | 55.00 | 26.16 | 9 | 114676 | 34222 | 46537155 |
Lower respiratory tract infection | 54.41 | 26.16 | 34 | 114651 | 55055 | 46516322 |
Discomfort | 54.26 | 26.16 | 243 | 114442 | 46427 | 46524950 |
Drug reaction with eosinophilia and systemic symptoms | 54.23 | 26.16 | 5 | 114680 | 29543 | 46541834 |
Heart rate decreased | 54.08 | 26.16 | 7 | 114678 | 31716 | 46539661 |
Gastrooesophageal reflux disease | 54.05 | 26.16 | 340 | 114345 | 74004 | 46497373 |
Red blood cell count decreased | 53.73 | 26.16 | 8 | 114677 | 32615 | 46538762 |
Blood creatine phosphokinase increased | 52.78 | 26.16 | 4 | 114681 | 27720 | 46543657 |
Medication error | 52.27 | 26.16 | 7 | 114678 | 30904 | 46540473 |
Sinus headache | 52.10 | 26.16 | 61 | 114624 | 4639 | 46566738 |
Suicide attempt | 51.60 | 26.16 | 36 | 114649 | 55000 | 46516377 |
Osteonecrosis | 51.11 | 26.16 | 3 | 114682 | 25741 | 46545636 |
Disorientation | 50.56 | 26.16 | 14 | 114671 | 36904 | 46534473 |
Arthritis | 50.37 | 26.16 | 344 | 114341 | 76972 | 46494405 |
Haematoma | 49.85 | 26.16 | 9 | 114676 | 31863 | 46539514 |
Gamma-glutamyltransferase increased | 49.56 | 26.16 | 9 | 114676 | 31731 | 46539646 |
Aphasia | 49.44 | 26.16 | 6 | 114679 | 28561 | 46542816 |
Hepatotoxicity | 49.39 | 26.16 | 3 | 114682 | 25006 | 46546371 |
Gait disturbance | 49.13 | 26.16 | 187 | 114498 | 145076 | 46426301 |
Bone erosion | 48.60 | 26.16 | 85 | 114600 | 9358 | 46562019 |
Visual impairment | 47.76 | 26.16 | 56 | 114629 | 66633 | 46504744 |
Melaena | 47.65 | 26.16 | 6 | 114679 | 27766 | 46543611 |
Chills | 47.63 | 26.16 | 103 | 114582 | 95929 | 46475448 |
Blood urea increased | 47.31 | 26.16 | 4 | 114681 | 25348 | 46546029 |
Hepatic function abnormal | 47.24 | 26.16 | 13 | 114672 | 34408 | 46536969 |
Agitation | 47.18 | 26.16 | 40 | 114645 | 55375 | 46516002 |
Chest discomfort | 47.14 | 26.16 | 94 | 114591 | 90175 | 46481202 |
Urinary incontinence | 46.98 | 26.16 | 7 | 114678 | 28523 | 46542854 |
Urinary retention | 46.29 | 26.16 | 5 | 114680 | 26056 | 46545321 |
Pancreatitis acute | 46.21 | 26.16 | 4 | 114681 | 24868 | 46546509 |
White blood cell count increased | 45.48 | 26.16 | 26 | 114659 | 44193 | 46527184 |
Lymphocyte count decreased | 45.22 | 26.16 | 5 | 114680 | 25584 | 46545793 |
Memory impairment | 45.09 | 26.16 | 335 | 114350 | 77002 | 46494375 |
Haemorrhage | 45.03 | 26.16 | 41 | 114644 | 54828 | 46516549 |
Epistaxis | 44.99 | 26.16 | 55 | 114630 | 64250 | 46507127 |
Hypoaesthesia | 44.90 | 26.16 | 146 | 114539 | 118723 | 46452654 |
Hypothyroidism | 44.60 | 26.16 | 11 | 114674 | 31327 | 46540050 |
Hand deformity | 43.95 | 26.16 | 15 | 114670 | 34559 | 46536818 |
Rash maculo-papular | 43.31 | 26.16 | 8 | 114677 | 27866 | 46543511 |
Haematuria | 43.29 | 26.16 | 7 | 114678 | 26851 | 46544526 |
Sinusitis | 43.08 | 26.16 | 498 | 114187 | 129270 | 46442107 |
Swelling | 42.93 | 26.16 | 159 | 114526 | 124352 | 46447025 |
Cerebral infarction | 42.76 | 26.16 | 4 | 114681 | 23362 | 46548015 |
Cerebral haemorrhage | 42.29 | 26.16 | 9 | 114676 | 28362 | 46543015 |
Speech disorder | 42.13 | 26.16 | 18 | 114667 | 36149 | 46535228 |
Blood sodium decreased | 41.75 | 26.16 | 3 | 114682 | 21723 | 46549654 |
Impaired healing | 41.68 | 26.16 | 19 | 114666 | 36724 | 46534653 |
Hospitalisation | 41.47 | 26.16 | 57 | 114628 | 63328 | 46508049 |
Abortion spontaneous | 40.33 | 26.16 | 29 | 114656 | 43617 | 46527760 |
Erythema | 40.25 | 26.16 | 197 | 114488 | 142623 | 46428754 |
Red blood cell sedimentation rate | 40.23 | 26.16 | 34 | 114651 | 1739 | 46569638 |
Palmoplantar pustulosis | 40.17 | 26.16 | 19 | 114666 | 341 | 46571036 |
Device related infection | 40.16 | 26.16 | 3 | 114682 | 21038 | 46550339 |
Exostosis | 39.94 | 26.16 | 82 | 114603 | 10181 | 46561196 |
Visual acuity reduced | 39.90 | 26.16 | 4 | 114681 | 22109 | 46549268 |
Pallor | 39.76 | 26.16 | 5 | 114680 | 23161 | 46548216 |
Rhinorrhoea | 39.10 | 26.16 | 225 | 114460 | 47440 | 46523937 |
Epilepsy | 38.68 | 26.16 | 6 | 114679 | 23732 | 46547645 |
Asthma | 38.47 | 26.16 | 107 | 114578 | 91435 | 46479942 |
Lung disorder | 38.43 | 26.16 | 30 | 114655 | 43274 | 46528103 |
Rheumatoid arthritis | 38.34 | 26.16 | 391 | 114294 | 239824 | 46331553 |
Injection site bruising | 38.03 | 26.16 | 20 | 114665 | 35616 | 46535761 |
Cholelithiasis | 38.02 | 26.16 | 24 | 114661 | 38657 | 46532720 |
Therapy partial responder | 37.97 | 26.16 | 52 | 114633 | 4630 | 46566747 |
Gastroenteritis viral | 37.75 | 26.16 | 114 | 114571 | 18005 | 46553372 |
Stevens-Johnson syndrome | 37.71 | 26.16 | 6 | 114679 | 23291 | 46548086 |
Mood swings | 37.45 | 26.16 | 106 | 114579 | 16146 | 46555231 |
Joint dislocation | 37.36 | 26.16 | 84 | 114601 | 11102 | 46560275 |
Constipation | 36.92 | 26.16 | 263 | 114422 | 173834 | 46397543 |
Blood potassium decreased | 36.89 | 26.16 | 24 | 114661 | 38039 | 46533338 |
Joint stiffness | 36.82 | 26.16 | 148 | 114537 | 26960 | 46544417 |
Metastases to liver | 36.80 | 26.16 | 3 | 114682 | 19582 | 46551795 |
Arrhythmia | 36.53 | 26.16 | 20 | 114665 | 34821 | 46536556 |
Aggression | 36.49 | 26.16 | 6 | 114679 | 22738 | 46548639 |
Circulatory collapse | 36.31 | 26.16 | 5 | 114680 | 21619 | 46549758 |
Wheezing | 35.95 | 26.16 | 47 | 114638 | 53339 | 46518038 |
Haemoptysis | 35.73 | 26.16 | 10 | 114675 | 26179 | 46545198 |
Skin exfoliation | 35.69 | 26.16 | 168 | 114517 | 32770 | 46538607 |
Transient ischaemic attack | 35.22 | 26.16 | 21 | 114664 | 34882 | 46536495 |
Pneumonitis | 34.98 | 26.16 | 13 | 114672 | 28407 | 46542970 |
Blood parathyroid hormone decreased | 34.54 | 26.16 | 48 | 114637 | 4333 | 46567044 |
Injection site reaction | 34.45 | 26.16 | 40 | 114645 | 47809 | 46523568 |
Dry skin | 33.89 | 26.16 | 194 | 114491 | 40822 | 46530555 |
Loss of personal independence in daily activities | 33.49 | 26.16 | 248 | 114437 | 56935 | 46514442 |
Sleep apnoea syndrome | 33.18 | 26.16 | 7 | 114678 | 22194 | 46549183 |
Hallucination, visual | 32.86 | 26.16 | 3 | 114682 | 17870 | 46553507 |
Abnormal behaviour | 32.81 | 26.16 | 6 | 114679 | 21052 | 46550325 |
Blood pressure fluctuation | 32.62 | 26.16 | 17 | 114668 | 30431 | 46540946 |
Orthostatic hypotension | 32.57 | 26.16 | 10 | 114675 | 24648 | 46546729 |
Malaise | 32.17 | 26.16 | 1052 | 113633 | 330180 | 46241197 |
Urinary tract infection | 32.14 | 26.16 | 366 | 114319 | 219900 | 46351477 |
Psychotic disorder | 32.07 | 26.16 | 8 | 114677 | 22613 | 46548764 |
Rash pruritic | 31.99 | 26.16 | 202 | 114483 | 44013 | 46527364 |
Granuloma skin | 31.93 | 26.16 | 41 | 114644 | 3429 | 46567948 |
Defaecation urgency | 31.89 | 26.16 | 36 | 114649 | 2631 | 46568746 |
Chronic obstructive pulmonary disease | 31.85 | 26.16 | 58 | 114627 | 57575 | 46513802 |
Rash macular | 31.84 | 26.16 | 112 | 114573 | 19148 | 46552229 |
Dactylitis | 31.52 | 26.16 | 25 | 114660 | 1168 | 46570209 |
Lethargy | 31.52 | 26.16 | 48 | 114637 | 51123 | 46520254 |
Multiple allergies | 31.20 | 26.16 | 61 | 114624 | 7310 | 46564067 |
Accidental exposure to product | 30.79 | 26.16 | 7 | 114678 | 21074 | 46550303 |
Intestinal obstruction | 30.33 | 26.16 | 13 | 114672 | 26062 | 46545315 |
General physical health deterioration | 30.17 | 26.16 | 164 | 114521 | 115605 | 46455772 |
Proteinuria | 29.85 | 26.16 | 3 | 114682 | 16550 | 46554827 |
Tongue disorder | 29.72 | 26.16 | 59 | 114626 | 7151 | 46564226 |
Swelling face | 29.67 | 26.16 | 53 | 114632 | 53006 | 46518371 |
Underdose | 29.57 | 26.16 | 6 | 114679 | 19552 | 46551825 |
Hepatic enzyme increased | 29.14 | 26.16 | 103 | 114582 | 81684 | 46489693 |
Adverse event | 29.11 | 26.16 | 163 | 114522 | 34021 | 46537356 |
Electrolyte imbalance | 28.89 | 26.16 | 4 | 114681 | 17222 | 46554155 |
Cardiomyopathy | 28.76 | 26.16 | 3 | 114682 | 16070 | 46555307 |
Amnesia | 28.70 | 26.16 | 36 | 114649 | 41595 | 46529782 |
Withdrawal syndrome | 28.62 | 26.16 | 5 | 114680 | 18129 | 46553248 |
Alopecia | 28.27 | 26.16 | 558 | 114127 | 161856 | 46409521 |
Therapy cessation | 28.25 | 26.16 | 135 | 114550 | 26494 | 46544883 |
Dandruff | 28.18 | 26.16 | 12 | 114673 | 166 | 46571211 |
Wrong technique in product usage process | 28.12 | 26.16 | 57 | 114628 | 54365 | 46517012 |
Blood calcium decreased | 27.85 | 26.16 | 3 | 114682 | 15670 | 46555707 |
Bowel movement irregularity | 27.71 | 26.16 | 38 | 114647 | 3387 | 46567990 |
Pregnancy | 27.65 | 26.16 | 136 | 114549 | 27001 | 46544376 |
Panniculitis | 27.62 | 26.16 | 50 | 114635 | 5654 | 46565723 |
Mobility decreased | 27.61 | 26.16 | 68 | 114617 | 60526 | 46510851 |
COVID-19 | 27.32 | 26.16 | 104 | 114581 | 18471 | 46552906 |
Contraindicated product administered | 26.96 | 26.16 | 103 | 114582 | 79844 | 46491533 |
Drug resistance | 26.95 | 26.16 | 5 | 114680 | 17363 | 46554014 |
Injection site haemorrhage | 26.29 | 26.16 | 9 | 114676 | 20700 | 46550677 |
Sinus disorder | 26.26 | 26.16 | 95 | 114590 | 16468 | 46554909 |
MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
---|---|---|---|---|---|---|
Psoriasis | 11562.56 | 34.13 | 3889 | 50588 | 38617 | 29859384 |
Diarrhoea | 6345.05 | 34.13 | 5007 | 49470 | 329096 | 29568905 |
Headache | 3829.10 | 34.13 | 2921 | 51556 | 179385 | 29718616 |
Product dose omission issue | 3805.40 | 34.13 | 2247 | 52230 | 89384 | 29808617 |
Nausea | 3408.32 | 34.13 | 3366 | 51111 | 293591 | 29604410 |
Abdominal discomfort | 2842.77 | 34.13 | 1498 | 52979 | 47293 | 29850708 |
Drug ineffective | 2368.01 | 34.13 | 2976 | 51501 | 337411 | 29560590 |
Psoriatic arthropathy | 2314.15 | 34.13 | 922 | 53555 | 14839 | 29883162 |
Depression | 819.75 | 34.13 | 912 | 53565 | 89525 | 29808476 |
Adverse drug reaction | 818.83 | 34.13 | 515 | 53962 | 22630 | 29875371 |
Abdominal pain upper | 665.15 | 34.13 | 687 | 53790 | 61864 | 29836137 |
Therapy non-responder | 610.26 | 34.13 | 472 | 54005 | 28981 | 29869020 |
Weight decreased | 524.57 | 34.13 | 963 | 53514 | 149958 | 29748043 |
Frequent bowel movements | 524.05 | 34.13 | 271 | 54206 | 8134 | 29889867 |
Therapeutic product effect decreased | 504.44 | 34.13 | 420 | 54057 | 28656 | 29869345 |
Gastric disorder | 414.20 | 34.13 | 251 | 54226 | 10292 | 29887709 |
Acute kidney injury | 406.41 | 34.13 | 23 | 54454 | 273819 | 29624182 |
Rash | 315.97 | 34.13 | 912 | 53565 | 190977 | 29707024 |
Drug interaction | 289.01 | 34.13 | 19 | 54458 | 199549 | 29698452 |
Anaemia | 278.53 | 34.13 | 28 | 54449 | 207964 | 29690037 |
Hypotension | 265.95 | 34.13 | 28 | 54449 | 200537 | 29697464 |
Faeces soft | 262.00 | 34.13 | 111 | 54366 | 2088 | 29895913 |
Gastrointestinal disorder | 259.54 | 34.13 | 287 | 54190 | 27850 | 29870151 |
Therapeutic response decreased | 257.43 | 34.13 | 267 | 54210 | 24082 | 29873919 |
Pyrexia | 253.16 | 34.13 | 110 | 54367 | 294379 | 29603622 |
Dyspepsia | 217.58 | 34.13 | 272 | 54205 | 30057 | 29867944 |
Dyspnoea | 202.08 | 34.13 | 186 | 54291 | 333109 | 29564892 |
Thrombocytopenia | 195.45 | 34.13 | 14 | 54463 | 137030 | 29760971 |
Arthralgia | 186.11 | 34.13 | 606 | 53871 | 135185 | 29762816 |
Flatulence | 183.01 | 34.13 | 194 | 54283 | 17935 | 29880066 |
Tension headache | 176.75 | 34.13 | 72 | 54405 | 1221 | 29896780 |
Pneumonia | 175.17 | 34.13 | 211 | 54266 | 334095 | 29563906 |
Febrile neutropenia | 167.52 | 34.13 | 6 | 54471 | 106687 | 29791314 |
Mood altered | 161.51 | 34.13 | 128 | 54349 | 8122 | 29889879 |
Respiratory failure | 156.83 | 34.13 | 6 | 54471 | 100636 | 29797365 |
Haemoglobin decreased | 156.12 | 34.13 | 14 | 54463 | 114084 | 29783917 |
Therapeutic product effect incomplete | 155.35 | 34.13 | 245 | 54232 | 33589 | 29864412 |
Confusional state | 146.46 | 34.13 | 33 | 54444 | 134801 | 29763200 |
Nasopharyngitis | 140.11 | 34.13 | 322 | 54155 | 58527 | 29839474 |
Cardiac arrest | 139.83 | 34.13 | 7 | 54470 | 92843 | 29805158 |
Migraine | 139.30 | 34.13 | 143 | 54334 | 12731 | 29885270 |
Overdose | 138.80 | 34.13 | 3 | 54474 | 84334 | 29813667 |
Memory impairment | 138.33 | 34.13 | 245 | 54232 | 36929 | 29861072 |
Sepsis | 138.19 | 34.13 | 47 | 54430 | 146348 | 29751653 |
Platelet count decreased | 135.01 | 34.13 | 17 | 54460 | 106112 | 29791889 |
Enthesopathy | 134.61 | 34.13 | 77 | 54400 | 2829 | 29895172 |
Completed suicide | 133.98 | 34.13 | 13 | 54464 | 99479 | 29798522 |
Upper respiratory tract infection | 130.34 | 34.13 | 202 | 54275 | 27274 | 29870727 |
Blood creatinine increased | 122.87 | 34.13 | 12 | 54465 | 91363 | 29806638 |
Pleural effusion | 120.46 | 34.13 | 3 | 54474 | 74063 | 29823938 |
Renal failure | 118.95 | 34.13 | 43 | 54434 | 128923 | 29769078 |
Pruritus | 116.36 | 34.13 | 474 | 54003 | 117730 | 29780271 |
Oedema peripheral | 114.69 | 34.13 | 26 | 54451 | 105806 | 29792195 |
Fall | 114.07 | 34.13 | 98 | 54379 | 181774 | 29716227 |
Product supply issue | 110.21 | 34.13 | 34 | 54443 | 239 | 29897762 |
Discomfort | 109.74 | 34.13 | 133 | 54344 | 14223 | 29883778 |
Pancytopenia | 109.68 | 34.13 | 13 | 54464 | 85039 | 29812962 |
Pulmonary embolism | 108.44 | 34.13 | 9 | 54468 | 78126 | 29819875 |
Seizure | 107.09 | 34.13 | 24 | 54453 | 98451 | 29799550 |
Hyperkalaemia | 102.58 | 34.13 | 4 | 54473 | 66006 | 29831995 |
Bradycardia | 101.72 | 34.13 | 4 | 54473 | 65522 | 29832479 |
Arthritis | 100.16 | 34.13 | 168 | 54309 | 24233 | 29873768 |
White blood cell count decreased | 98.53 | 34.13 | 17 | 54460 | 83930 | 29814071 |
Tenosynovitis | 96.84 | 34.13 | 67 | 54410 | 3448 | 29894553 |
Death | 96.48 | 34.13 | 331 | 54146 | 356952 | 29541049 |
Deep vein thrombosis | 96.34 | 34.13 | 3 | 54474 | 60498 | 29837503 |
Multiple organ dysfunction syndrome | 94.88 | 34.13 | 5 | 54472 | 63482 | 29834519 |
Product use in unapproved indication | 93.21 | 34.13 | 12 | 54465 | 73681 | 29824320 |
Gastrointestinal haemorrhage | 91.40 | 34.13 | 20 | 54457 | 83426 | 29814575 |
Asthenia | 89.09 | 34.13 | 167 | 54310 | 221123 | 29676878 |
Syncope | 87.78 | 34.13 | 23 | 54454 | 84880 | 29813121 |
Unevaluable event | 84.68 | 34.13 | 182 | 54295 | 31603 | 29866398 |
Tachycardia | 84.23 | 34.13 | 16 | 54461 | 73723 | 29824278 |
Plasma cell myeloma | 83.88 | 34.13 | 3 | 54474 | 53459 | 29844542 |
Interstitial lung disease | 83.33 | 34.13 | 7 | 54470 | 60190 | 29837811 |
Insomnia | 82.99 | 34.13 | 363 | 54114 | 92973 | 29805028 |
Disease progression | 80.02 | 34.13 | 23 | 54454 | 79851 | 29818150 |
Septic shock | 74.37 | 34.13 | 13 | 54464 | 63594 | 29834407 |
Dehydration | 73.28 | 34.13 | 70 | 54407 | 123469 | 29774532 |
Hypokalaemia | 71.83 | 34.13 | 5 | 54472 | 50187 | 29847814 |
Cardiac failure congestive | 71.48 | 34.13 | 32 | 54445 | 84375 | 29813626 |
General physical health deterioration | 70.03 | 34.13 | 48 | 54429 | 99896 | 29798105 |
Tongue disorder | 69.83 | 34.13 | 60 | 54417 | 4262 | 29893739 |
Renal impairment | 68.08 | 34.13 | 34 | 54443 | 84150 | 29813851 |
Neuropathy peripheral | 67.51 | 34.13 | 22 | 54455 | 70453 | 29827548 |
Rhinorrhoea | 67.35 | 34.13 | 129 | 54348 | 20625 | 29877376 |
Pain | 67.25 | 34.13 | 540 | 53937 | 172101 | 29725900 |
Off label use | 67.08 | 34.13 | 231 | 54246 | 249059 | 29648942 |
Mood swings | 65.49 | 34.13 | 75 | 54402 | 7551 | 29890450 |
Sinus headache | 64.69 | 34.13 | 33 | 54444 | 960 | 29897041 |
Loss of consciousness | 64.27 | 34.13 | 32 | 54445 | 79343 | 29818658 |
C-reactive protein abnormal | 63.91 | 34.13 | 64 | 54413 | 5529 | 29892472 |
Acute myocardial infarction | 63.71 | 34.13 | 10 | 54467 | 52929 | 29845072 |
Hypoxia | 62.45 | 34.13 | 7 | 54470 | 47847 | 29850154 |
Tendonitis | 60.67 | 34.13 | 74 | 54403 | 7962 | 29890039 |
Atrial fibrillation | 58.75 | 34.13 | 66 | 54411 | 108058 | 29789943 |
Cardiac failure | 58.51 | 34.13 | 40 | 54437 | 83378 | 29814623 |
Infusion related reaction | 58.16 | 34.13 | 4 | 54473 | 40560 | 29857441 |
Myocardial infarction | 55.75 | 34.13 | 89 | 54388 | 125536 | 29772465 |
Drug intolerance | 55.53 | 34.13 | 195 | 54282 | 45096 | 29852905 |
Hepatic function abnormal | 55.08 | 34.13 | 6 | 54471 | 41939 | 29856062 |
Treatment failure | 54.93 | 34.13 | 163 | 54314 | 34516 | 29863485 |
Alanine aminotransferase abnormal | 54.20 | 34.13 | 42 | 54435 | 2577 | 29895424 |
Haematuria | 52.76 | 34.13 | 9 | 54468 | 44825 | 29853176 |
Coronary artery disease | 52.26 | 34.13 | 13 | 54464 | 49699 | 29848302 |
Synovitis | 52.17 | 34.13 | 76 | 54401 | 9707 | 29888294 |
Arthropathy | 52.14 | 34.13 | 116 | 54361 | 20611 | 29877390 |
Sinusitis | 52.12 | 34.13 | 156 | 54321 | 33189 | 29864812 |
Loss of personal independence in daily activities | 51.36 | 34.13 | 118 | 54359 | 21417 | 29876584 |
Leukopenia | 51.25 | 34.13 | 19 | 54458 | 56140 | 29841861 |
Oedema | 49.78 | 34.13 | 9 | 54468 | 42984 | 29855017 |
Decreased appetite | 49.43 | 34.13 | 452 | 54025 | 149458 | 29748543 |
Pulmonary oedema | 49.23 | 34.13 | 10 | 54467 | 43965 | 29854036 |
Feeling abnormal | 49.07 | 34.13 | 219 | 54258 | 56537 | 29841464 |
Chest pain | 48.81 | 34.13 | 87 | 54390 | 117540 | 29780461 |
Blood bilirubin increased | 48.72 | 34.13 | 5 | 54472 | 36631 | 29861370 |
Coma | 47.86 | 34.13 | 8 | 54469 | 40441 | 29857560 |
Therapy partial responder | 47.34 | 34.13 | 45 | 54432 | 3646 | 29894355 |
Mental status changes | 46.96 | 34.13 | 6 | 54471 | 37073 | 29860928 |
Blood alkaline phosphatase increased | 45.45 | 34.13 | 3 | 54474 | 31484 | 29866517 |
Epistaxis | 44.97 | 34.13 | 20 | 54457 | 52961 | 29845040 |
Dyspnoea exertional | 44.23 | 34.13 | 6 | 54471 | 35424 | 29862577 |
Encephalopathy | 43.87 | 34.13 | 4 | 54473 | 32201 | 29865800 |
Hyperglycaemia | 43.85 | 34.13 | 6 | 54471 | 35194 | 29862807 |
Product use issue | 42.95 | 34.13 | 15 | 54462 | 46001 | 29852000 |
Chills | 42.84 | 34.13 | 41 | 54436 | 72297 | 29825704 |
Dysphagia | 42.75 | 34.13 | 25 | 54452 | 56673 | 29841328 |
Stomatitis | 42.74 | 34.13 | 8 | 54469 | 37271 | 29860730 |
Muscular weakness | 42.68 | 34.13 | 32 | 54445 | 63613 | 29834388 |
Somnolence | 42.49 | 34.13 | 69 | 54408 | 96694 | 29801307 |
Blood urea increased | 42.47 | 34.13 | 4 | 54473 | 31377 | 29866624 |
Hallucination | 42.46 | 34.13 | 18 | 54459 | 49041 | 29848960 |
Lactic acidosis | 42.18 | 34.13 | 4 | 54473 | 31209 | 29866792 |
Gamma-glutamyltransferase increased | 41.77 | 34.13 | 3 | 54474 | 29347 | 29868654 |
Jaundice | 41.76 | 34.13 | 5 | 54472 | 32481 | 29865520 |
Chronic kidney disease | 41.54 | 34.13 | 9 | 54468 | 37829 | 29860172 |
Weight increased | 39.30 | 34.13 | 47 | 54430 | 74866 | 29823135 |
Bowel movement irregularity | 38.74 | 34.13 | 33 | 54444 | 2316 | 29895685 |
Pneumonitis | 38.52 | 34.13 | 3 | 54474 | 27451 | 29870550 |
Depressed mood | 38.08 | 34.13 | 91 | 54386 | 16938 | 29881063 |
Influenza | 37.91 | 34.13 | 168 | 54309 | 43230 | 29854771 |
Rash macular | 36.83 | 34.13 | 67 | 54410 | 10300 | 29887701 |
Stress | 36.80 | 34.13 | 100 | 54377 | 20135 | 29877866 |
Cerebral infarction | 36.67 | 34.13 | 3 | 54474 | 26370 | 29871631 |
Acute respiratory failure | 35.78 | 34.13 | 3 | 54474 | 25847 | 29872154 |
Intentional product use issue | 35.55 | 34.13 | 11 | 54466 | 36429 | 29861572 |
Cerebrovascular accident | 35.28 | 34.13 | 61 | 54416 | 83416 | 29814585 |
Muscle swelling | 35.17 | 34.13 | 16 | 54461 | 359 | 29897642 |
Hepatocellular injury | 35.13 | 34.13 | 3 | 54474 | 25468 | 29872533 |
Rash maculo-papular | 35.04 | 34.13 | 3 | 54474 | 25415 | 29872586 |
Skin fissures | 35.03 | 34.13 | 37 | 54440 | 3402 | 29894599 |
Liver function test abnormal | 34.72 | 34.13 | 7 | 54470 | 30943 | 29867058 |
Anaphylactic reaction | 34.31 | 34.13 | 5 | 54472 | 27977 | 29870024 |
Suicide attempt | 34.18 | 34.13 | 12 | 54465 | 36685 | 29861316 |
Source | Code | Description |
---|---|---|
ATC | L04AA32 | ANTINEOPLASTIC AND IMMUNOMODULATING AGENTS IMMUNOSUPPRESSANTS IMMUNOSUPPRESSANTS Selective immunosuppressants |
MeSH PA | D000700 | Analgesics |
MeSH PA | D018712 | Analgesics, Non-Narcotic |
MeSH PA | D000893 | Anti-Inflammatory Agents |
MeSH PA | D000894 | Anti-Inflammatory Agents, Non-Steroidal |
MeSH PA | D018501 | Antirheumatic Agents |
MeSH PA | D004791 | Enzyme Inhibitors |
MeSH PA | D018373 | Peripheral Nervous System Agents |
MeSH PA | D058988 | Phosphodiesterase 4 Inhibitors |
MeSH PA | D010726 | Phosphodiesterase Inhibitors |
MeSH PA | D018689 | Sensory System Agents |
CHEBI has role | CHEBI:35475 | non-steroidal anti-inflammatory drugs |
CHEBI has role | CHEBI:68844 | pde4 inhibitors |
Disease | Relation | SNOMED_ID | DOID |
---|---|---|---|
Psoriasis with arthropathy | indication | 33339001 | |
Plaque psoriasis | indication | 200965009 | |
Behçet's disease affecting oral mucosa | indication | 403443000 |
None
None
Formulation strength | Trade name | Applicant | Application number | Approval date | Type | Dose form | Route | Exclusivity date | Description |
---|---|---|---|---|---|---|---|---|---|
10MG | OTEZLA | AMGEN INC | N205437 | March 21, 2014 | RX | TABLET | ORAL | July 19, 2022 | TREATMENT OF ADULT PATIENTS WITH ORAL ULCERS ASSOCIATED WITH BEHCETS DISEASE |
20MG | OTEZLA | AMGEN INC | N205437 | March 21, 2014 | RX | TABLET | ORAL | July 19, 2022 | TREATMENT OF ADULT PATIENTS WITH ORAL ULCERS ASSOCIATED WITH BEHCETS DISEASE |
30MG | OTEZLA | AMGEN INC | N205437 | March 21, 2014 | RX | TABLET | ORAL | July 19, 2022 | TREATMENT OF ADULT PATIENTS WITH ORAL ULCERS ASSOCIATED WITH BEHCETS DISEASE |
10MG | OTEZLA | AMGEN INC | N205437 | March 21, 2014 | RX | TABLET | ORAL | April 10, 2023 | INFORMATION ADDED TO THE CLINICAL STUDIES SECTION OF THE LABELING REGARDING THE USE OF PLAQUE PSORIASIS OF THE SCALP |
20MG | OTEZLA | AMGEN INC | N205437 | March 21, 2014 | RX | TABLET | ORAL | April 10, 2023 | INFORMATION ADDED TO THE CLINICAL STUDIES SECTION OF THE LABELING REGARDING THE USE OF PLAQUE PSORIASIS OF THE SCALP |
30MG | OTEZLA | AMGEN INC | N205437 | March 21, 2014 | RX | TABLET | ORAL | April 10, 2023 | INFORMATION ADDED TO THE CLINICAL STUDIES SECTION OF THE LABELING REGARDING THE USE OF PLAQUE PSORIASIS OF THE SCALP |
10MG | OTEZLA | AMGEN INC | N205437 | March 21, 2014 | RX | TABLET | ORAL | July 19, 2026 | TREATMENT OF ADULT PATIENTS WITH ORAL ULCERS ASSOCIATED WITH BEHCETS DISEASE |
20MG | OTEZLA | AMGEN INC | N205437 | March 21, 2014 | RX | TABLET | ORAL | July 19, 2026 | TREATMENT OF ADULT PATIENTS WITH ORAL ULCERS ASSOCIATED WITH BEHCETS DISEASE |
30MG | OTEZLA | AMGEN INC | N205437 | March 21, 2014 | RX | TABLET | ORAL | July 19, 2026 | TREATMENT OF ADULT PATIENTS WITH ORAL ULCERS ASSOCIATED WITH BEHCETS DISEASE |
Target | Class | Pharos | UniProt | Action | Type | Activity value (-log[M]) | Mechanism action | Bioact source | MoA source |
---|---|---|---|---|---|---|---|---|---|
cAMP-specific 3',5'-cyclic phosphodiesterase 4D | Enzyme | INHIBITOR | IC50 | 7.13 | SCIENTIFIC LITERATURE | SCIENTIFIC LITERATURE | |||
cAMP-specific 3',5'-cyclic phosphodiesterase 4A | Enzyme | INHIBITOR | IC50 | 7.85 | IUPHAR | ||||
cAMP-specific 3',5'-cyclic phosphodiesterase 4C | Enzyme | INHIBITOR | IC50 | 6.93 | IUPHAR | ||||
cAMP-specific 3',5'-cyclic phosphodiesterase 4B | Enzyme | INHIBITOR | IC50 | 7.57 | IUPHAR |
ID | Source |
---|---|
UP7QBP99PN | UNII |
D08860 | KEGG_DRUG |
4033216 | VUID |
N0000190644 | NUI |
4033216 | VANDF |
C1678805 | UMLSCUI |
CHEBI:78540 | CHEBI |
A9L | PDB_CHEM_ID |
CHEMBL514800 | ChEMBL_ID |
DB05676 | DRUGBANK_ID |
11561674 | PUBCHEM_CID |
8872 | INN_ID |
C505730 | MESH_SUPPLEMENTAL_RECORD_UI |
7372 | IUPHAR_LIGAND_ID |
1492727 | RXNORM |
213427 | MMSL |
30225 | MMSL |
d08247 | MMSL |
015411 | NDDF |
703350008 | SNOMEDCT_US |
714684002 | SNOMEDCT_US |
Product | Category | Ingredients | NDC | Form | Quantity | Route | Marketing | Label |
---|---|---|---|---|---|---|---|---|
Otezla | HUMAN PRESCRIPTION DRUG LABEL | 1 | 55513-137 | TABLET, FILM COATED | 30 mg | ORAL | NDA | 29 sections |
OTEZLA | HUMAN PRESCRIPTION DRUG LABEL | 1 | 59572-631 | TABLET, FILM COATED | 30 mg | ORAL | NDA | 25 sections |