mycophenolic acid 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definition	Drug id	CAS RN
	1860	37415-62-6

Description:

Molecule	Description
Molfile Inchi Smiles Synonyms: mycophenolate mycophenolic acid mycophenolate sodium mycophenolic acid monosodium salt sodium mycophenolate	Compound derived from Penicillium stoloniferum and related species. It blocks de novo biosynthesis of purine nucleotides by inhibition of the enzyme inosine monophosphate dehydrogenase (IMP DEHYDROGENASE). Mycophenolic acid exerts selective effects on the immune system in which it prevents the proliferation of T-CELLS, LYMPHOCYTES, and the formation of antibodies from B-CELLS. It may also inhibit recruitment of LEUKOCYTES to sites of INFLAMMATION. Molecular weight: 320.34 Formula: C17H20O6 CLOGP: 2.29 LIPINSKI: 0 HAC: 6 HDO: 2 TPSA: 93.06 ALOGS: -3.96 ROTB: 6 Status: OFP Legend: OFP - off patent OFM - off market ONP - on patent

Molecule

Description

Molfile Inchi Smiles

Synonyms:

mycophenolate
mycophenolic acid
mycophenolate sodium
mycophenolic acid monosodium salt
sodium mycophenolate

Compound derived from Penicillium stoloniferum and related species. It blocks de novo biosynthesis of purine nucleotides by inhibition of the enzyme inosine monophosphate dehydrogenase (IMP DEHYDROGENASE). Mycophenolic acid exerts selective effects on the immune system in which it prevents the proliferation of T-CELLS, LYMPHOCYTES, and the formation of antibodies from B-CELLS. It may also inhibit recruitment of LEUKOCYTES to sites of INFLAMMATION.

Molecular weight: 320.34
Formula: C17H20O6
CLOGP: 2.29
LIPINSKI: 0
HAC: 6
HDO: 2
TPSA: 93.06
ALOGS: -3.96
ROTB: 6

Status: OFP

Legend:
OFP - off patent
OFM - off market
ONP - on patent

Drug dosage:

Dose	Unit	Route
2	g	O
2	g	P

ADMET properties:

Property	Value	Reference
BDDCS (Biopharmaceutical Drug Disposition Classification System)	2	Benet LZ, Broccatelli F, Oprea TI
EoM (Fraction excreted unchanged in urine)	0.50 %	Benet LZ, Broccatelli F, Oprea TI
MRTD (Maximum Recommended Therapeutic Daily Dose)	64.22 µM/kg/day	Contrera JF, Matthews EJ, Kruhlak NL, Benz RD
Vd (Volume of distribution)	0.77 L/kg	Lombardo F, Berellini G, Obach RS
CL (Clearance)	2.33 mL/min/kg	Lombardo F, Berellini G, Obach RS
fu (Fraction unbound in plasma)	0.02 %	Lombardo F, Berellini G, Obach RS
t_half (Half-life)	9.70 hours	Lombardo F, Berellini G, Obach RS

Approvals:

Date	Agency	Company	Orphan
Feb. 27, 2004	FDA	NOVARTIS

FDA Adverse Event Reporting System (Female)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Cytomegalovirus infection	731.77	12.08	305	29551	17657	50557611
Transplant rejection	518.96	12.08	200	29656	9409	50565859
Kidney transplant rejection	426.58	12.08	138	29718	3849	50571419
Post transplant lymphoproliferative disorder	344.33	12.08	119	29737	4085	50571183
Complications of transplanted kidney	306.85	12.08	93	29763	2080	50573188
Polyomavirus-associated nephropathy	234.56	12.08	70	29786	1482	50573786
Thrombotic microangiopathy	222.22	12.08	107	29749	8684	50566584
Cytomegalovirus viraemia	198.45	12.08	82	29774	4627	50570641
BK virus infection	192.04	12.08	70	29786	2811	50572457
Product use in unapproved indication	188.27	12.08	283	29573	115536	50459732
COVID-19	185.91	12.08	180	29676	46482	50528786
Epstein-Barr virus infection	182.43	12.08	87	29769	6910	50568358
Posterior reversible encephalopathy syndrome	176.72	12.08	110	29746	14818	50560450
Immunosuppressant drug level increased	165.79	12.08	64	29792	3018	50572250
Off label use	163.91	12.08	631	29225	473795	50101473
Delayed graft function	158.31	12.08	46	29810	884	50574384
Leukopenia	156.53	12.08	196	29660	67332	50507936
Kidney fibrosis	141.89	12.08	48	29808	1541	50573727
Pneumocystis jirovecii pneumonia	139.02	12.08	94	29762	14569	50560699
Chronic allograft nephropathy	126.94	12.08	36	29820	632	50574636
Parvovirus B19 infection	123.85	12.08	33	29823	454	50574814
Blood creatinine increased	112.27	12.08	178	29678	75982	50499286
Renal impairment	110.38	12.08	176	29680	75485	50499783
Nephropathy toxic	107.42	12.08	64	29792	7965	50567303
Graft versus host disease in skin	99.27	12.08	42	29814	2514	50572754
Trichodysplasia spinulosa	95.15	12.08	27	29829	475	50574793
Graft versus host disease in gastrointestinal tract	92.62	12.08	41	29815	2740	50572528
Histoplasmosis disseminated	92.27	12.08	33	29823	1253	50574015
Multiple organ dysfunction syndrome	91.81	12.08	130	29726	50207	50525061
Escherichia infection	89.33	12.08	64	29792	10877	50564391
Tubulointerstitial nephritis	89.06	12.08	73	29783	15138	50560130
West Nile viral infection	88.46	12.08	24	29832	355	50574913
Cryptococcosis	87.94	12.08	29	29827	859	50574409
Aspergillus infection	87.70	12.08	53	29803	6768	50568500
Renal transplant failure	85.53	12.08	26	29830	587	50574681
Varicella zoster virus infection	83.88	12.08	37	29819	2452	50572816
Lymphocele	83.01	12.08	27	29829	765	50574503
Human herpesvirus 6 infection	82.25	12.08	37	29819	2569	50572699
Epstein-Barr viraemia	80.34	12.08	27	29829	849	50574419
Acute kidney injury	78.82	12.08	304	29552	227754	50347514
Transplant dysfunction	77.81	12.08	43	29813	4641	50570627
Respiratory failure	73.93	12.08	165	29691	91016	50484252
Arthropathy	70.83	12.08	6	29850	157900	50417368
Fatigue	70.35	12.08	201	29655	707400	49867868
Apoptosis	69.38	12.08	15	29841	77	50575191
Pain	67.09	12.08	152	29704	578751	49996517
Graft loss	66.76	12.08	19	29837	338	50574930
Adenovirus infection	66.52	12.08	34	29822	3134	50572134
Liver transplant rejection	66.19	12.08	26	29830	1284	50573984
Polyomavirus viraemia	61.76	12.08	19	29837	447	50574821
Histoplasmosis	58.80	12.08	26	29830	1733	50573535
Post transplant distal limb syndrome	58.41	12.08	15	29841	177	50575091
Aplasia pure red cell	57.43	12.08	34	29822	4181	50571087
Cytomegalovirus colitis	56.52	12.08	26	29830	1901	50573367
Diffuse large B-cell lymphoma	55.34	12.08	37	29819	5625	50569643
Focal segmental glomerulosclerosis	55.30	12.08	23	29833	1318	50573950
JC virus infection	54.84	12.08	25	29831	1790	50573478
Bronchopulmonary aspergillosis	54.28	12.08	41	29815	7551	50567717
Klebsiella infection	54.00	12.08	40	29816	7154	50568114
Renal tubular atrophy	53.68	12.08	18	29838	562	50574706
Drug hypersensitivity	53.35	12.08	42	29814	250968	50324300
Disseminated cryptococcosis	52.10	12.08	16	29840	374	50574894
Human polyomavirus infection	52.08	12.08	15	29841	279	50574989
Ureaplasma infection	51.63	12.08	17	29839	501	50574767
Human ehrlichiosis	50.50	12.08	13	29843	155	50575113
Blastomycosis	49.95	12.08	14	29842	235	50575033
Haemophagocytic lymphohistiocytosis	49.63	12.08	41	29815	8592	50566676
Rash	48.87	12.08	117	29739	437354	50137914
Pancreas transplant rejection	48.00	12.08	12	29844	126	50575142
Drug level increased	47.93	12.08	58	29798	19210	50556058
Arthralgia	46.91	12.08	120	29736	438582	50136686
Graft versus host disease	45.64	12.08	34	29822	6132	50569136
Fall	45.50	12.08	80	29776	334852	50240416
Central nervous system lymphoma	45.06	12.08	20	29836	1345	50573923
Contraindicated product administered	44.71	12.08	16	29840	148942	50426326
Diabetes mellitus	43.44	12.08	92	29764	48941	50526327
Viraemia	42.86	12.08	18	29838	1057	50574211
Angiosarcoma	42.19	12.08	12	29844	213	50575055
Renal tubular necrosis	41.91	12.08	40	29816	10128	50565140
Phaeohyphomycosis	41.57	12.08	12	29844	225	50575043
Injection site pain	40.74	12.08	8	29848	111016	50464252
Renal transplant	40.68	12.08	18	29838	1201	50574067
Proteinuria	39.72	12.08	49	29807	16548	50558720
Immunosuppressant drug level decreased	39.46	12.08	16	29840	859	50574409
Encephalitis viral	39.02	12.08	19	29837	1578	50573690
Joint swelling	38.62	12.08	53	29803	245233	50330035
Toxoplasmosis	38.09	12.08	18	29838	1399	50573869
Nocardiosis	37.92	12.08	19	29837	1679	50573589
Haemolytic uraemic syndrome	37.73	12.08	21	29835	2298	50572970
Disseminated mucormycosis	37.30	12.08	10	29846	141	50575127
Biopsy lung abnormal	37.23	12.08	10	29846	142	50575126
Hypersensitivity	36.44	12.08	44	29812	215117	50360151
Diarrhoea	36.13	12.08	516	29340	587960	49987308
Atypical haemolytic uraemic syndrome	35.14	12.08	13	29843	544	50574724
Renal failure	35.00	12.08	140	29716	106493	50468775
Acute graft versus host disease	34.26	12.08	24	29832	3934	50571334
Interstitial lung disease	34.19	12.08	88	29768	53088	50522180
Enterococcal infection	34.01	12.08	30	29826	6868	50568400
Alveolar proteinosis	33.91	12.08	11	29845	309	50574959
Synovitis	32.83	12.08	16	29840	123849	50451419
Infusion related reaction	32.80	12.08	31	29825	169526	50405742
Wound	32.37	12.08	11	29845	105783	50469485
Acute respiratory distress syndrome	32.00	12.08	50	29806	21049	50554219
Gastroenteritis norovirus	31.69	12.08	17	29839	1730	50573538
Pyrexia	31.65	12.08	353	29503	379850	50195418
Rhodococcus infection	31.42	12.08	8	29848	91	50575177
Dizziness	30.96	12.08	103	29753	346266	50229002
Hypogammaglobulinaemia	30.55	12.08	26	29830	5673	50569595
Escherichia urinary tract infection	30.38	12.08	34	29822	10361	50564907
Pruritus	29.91	12.08	78	29778	283490	50291778
Protein urine present	29.79	12.08	25	29831	5352	50569916
Rheumatoid arthritis	29.68	12.08	46	29810	202504	50372764
Malacoplakia vesicae	29.60	12.08	7	29849	57	50575211
Pseudomonas infection	29.56	12.08	32	29824	9398	50565870
Biloma	29.28	12.08	7	29849	60	50575208
Malacoplakia gastrointestinal	29.07	12.08	7	29849	62	50575206
Swelling	29.07	12.08	46	29810	200826	50374442
Hospitalisation	28.86	12.08	97	29759	67840	50507428
Cystitis haemorrhagic	28.72	12.08	21	29835	3681	50571587
Discomfort	28.72	12.08	14	29842	108366	50466902
Urinary tract infection	28.65	12.08	228	29628	223792	50351476
Stomatitis	28.56	12.08	12	29844	101332	50473936
Brain abscess	28.54	12.08	16	29840	1775	50573493
Vaccination failure	28.41	12.08	10	29846	362	50574906
Microsporidia infection	28.37	12.08	9	29847	235	50575033
Injection site erythema	28.34	12.08	5	29851	74931	50500337
Mycobacterium avium complex infection	28.31	12.08	18	29838	2512	50572756
Haemolytic anaemia	28.20	12.08	31	29825	9261	50566007
Renal tubular injury	27.83	12.08	10	29846	385	50574883
Progressive multifocal leukoencephalopathy	27.70	12.08	34	29822	11423	50563845
Human herpesvirus 6 encephalitis	27.66	12.08	8	29848	151	50575117
Disseminated mycobacterium avium complex infection	27.25	12.08	6	29850	34	50575234
Philadelphia positive chronic myeloid leukaemia	27.11	12.08	6	29850	35	50575233
Acute graft versus host disease in intestine	27.10	12.08	15	29841	1624	50573644
Malignant neoplasm progression	26.98	12.08	4	29852	68120	50507148
Lupus nephritis	26.97	12.08	17	29839	2338	50572930
End stage renal disease	26.40	12.08	24	29832	5713	50569555
Insomnia	26.30	12.08	39	29817	174826	50400442
Pyelonephritis	26.26	12.08	38	29818	14951	50560317
Cytomegalovirus hepatitis	26.05	12.08	9	29847	308	50574960
Bacterial pyelonephritis	25.75	12.08	9	29847	319	50574949
Pemphigus	25.63	12.08	20	29836	120146	50455122
Graft complication	25.47	12.08	8	29848	202	50575066
Anxiety	25.38	12.08	41	29815	177565	50397703
Obliterative bronchiolitis	25.38	12.08	15	29841	1838	50573430
Hepatitis E	25.25	12.08	13	29843	1216	50574052
Lymphopenia	25.06	12.08	38	29818	15583	50559685
Disseminated varicella zoster vaccine virus infection	25.04	12.08	6	29850	52	50575216
Chromoblastomycosis	25.01	12.08	5	29851	16	50575252
Infection reactivation	24.89	12.08	12	29844	975	50574293
Contusion	24.79	12.08	18	29838	112165	50463103
Cytomegalovirus nephritis	24.78	12.08	5	29851	17	50575251
Depression	24.77	12.08	37	29819	165386	50409882
Herpes simplex oesophagitis	24.67	12.08	7	29849	123	50575145
Incision site pain	24.62	12.08	12	29844	999	50574269
Diabetic macroangiopathy	24.57	12.08	7	29849	125	50575143
Hyperammonaemia	24.20	12.08	21	29835	4703	50570565
Intentional overdose	24.01	12.08	4	29852	62500	50512768
Escherichia pyelonephritis	24.01	12.08	9	29847	391	50574877
Urinary fistula	23.95	12.08	5	29851	21	50575247
Alopecia	23.90	12.08	70	29786	244977	50330291
Anogenital warts	23.83	12.08	9	29847	399	50574869
Septic shock	23.73	12.08	81	29775	57094	50518174
Nasopharyngitis	23.60	12.08	49	29807	192878	50382390
Agranulocytosis	23.54	12.08	44	29812	21377	50553891
Coccidioidomycosis	23.33	12.08	11	29845	851	50574417
Psoriasis	23.24	12.08	6	29850	68994	50506274
Liver abscess	23.09	12.08	16	29840	2577	50572691
Osteoarthritis	23.04	12.08	6	29850	68600	50506668
Heart transplant rejection	22.90	12.08	9	29847	445	50574823
Perinephric abscess	22.78	12.08	7	29849	164	50575104
Cytomegalovirus chorioretinitis	22.76	12.08	13	29843	1494	50573774
Drug interaction	22.74	12.08	198	29658	199423	50375845
Cat scratch disease	22.74	12.08	7	29849	165	50575103
Blister	22.68	12.08	11	29845	85407	50489861
Pancytopenia	22.68	12.08	104	29752	83926	50491342
Pyelonephritis acute	22.65	12.08	19	29837	4064	50571204
Enterobacter infection	22.55	12.08	14	29842	1874	50573394
Polyomavirus test positive	22.55	12.08	6	29850	82	50575186
Suicidal ideation	22.53	12.08	3	29853	55382	50519886
Central nervous system lupus	22.39	12.08	8	29848	303	50574965
Cerebral toxoplasmosis	22.30	12.08	10	29846	689	50574579
Cytomegalovirus syndrome	22.22	12.08	6	29850	87	50575181
Balance disorder	22.18	12.08	7	29849	70583	50504685
Necrotising herpetic retinopathy	22.16	12.08	6	29850	88	50575180
Disseminated cytomegaloviral infection	22.13	12.08	7	29849	181	50575087
Mycobacterial infection	22.07	12.08	13	29843	1583	50573685
Systemic candida	22.04	12.08	16	29840	2774	50572494
Abdominal discomfort	21.99	12.08	67	29789	231574	50343694
Lung transplant	21.86	12.08	16	29840	2809	50572459
Urinary tract candidiasis	21.85	12.08	9	29847	503	50574765
Herpes simplex hepatitis	21.85	12.08	8	29848	325	50574943
Papilloma viral infection	21.71	12.08	12	29844	1295	50573973
Hydronephrosis	21.71	12.08	26	29830	8515	50566753
Urinoma	21.68	12.08	5	29851	36	50575232
Sepsis	21.40	12.08	143	29713	132782	50442486
Lung transplant rejection	21.38	12.08	10	29846	759	50574509
Mucormycosis	21.36	12.08	15	29841	2468	50572800
Neutropenia	21.36	12.08	155	29701	147810	50427458
Oesophageal candidiasis	21.25	12.08	20	29836	4974	50570294
Pneumopericardium	21.22	12.08	5	29851	40	50575228
Pyelonephritis fungal	21.07	12.08	6	29850	107	50575161
Complications of transplanted lung	20.89	12.08	7	29849	218	50575050
Rhinovirus infection	20.76	12.08	17	29839	3517	50571751
Human herpesvirus 8 infection	20.71	12.08	7	29849	224	50575044
Transplant failure	20.68	12.08	12	29844	1421	50573847
Candida infection	20.66	12.08	44	29812	23479	50551789
Pain in extremity	20.54	12.08	87	29769	272778	50302490
Acid base balance abnormal	20.25	12.08	7	29849	240	50575028
Dermatitis papillaris capillitii	20.21	12.08	4	29852	12	50575256
Systemic bacterial infection	20.21	12.08	4	29852	12	50575256
Drug level decreased	20.18	12.08	22	29834	6511	50568757
Ureteral necrosis	20.13	12.08	5	29851	51	50575217
Donor specific antibody present	20.10	12.08	6	29850	127	50575141
Nosocomial infection	20.01	12.08	12	29844	1510	50573758
Chronic kidney disease	19.82	12.08	60	29796	39711	50535557
Therapeutic product effect decreased	19.82	12.08	31	29825	136019	50439249
Mucinous adenocarcinoma of appendix	19.74	12.08	4	29852	14	50575254
Pneumonia cytomegaloviral	19.73	12.08	13	29843	1928	50573340
Encephalitis	19.64	12.08	23	29833	7357	50567911
Pericarditis	19.61	12.08	11	29845	78678	50496590
Plasmapheresis	19.59	12.08	7	29849	265	50575003
Mycobacterium chelonae infection	19.56	12.08	8	29848	439	50574829
Helicobacter infection	19.50	12.08	3	29853	49699	50525569
Forced vital capacity decreased	19.47	12.08	10	29846	931	50574337
Back pain	19.24	12.08	66	29790	219964	50355304
Concomitant disease progression	19.11	12.08	13	29843	2032	50573236
Renal lymphocele	19.02	12.08	5	29851	65	50575203
American trypanosomiasis	18.95	12.08	5	29851	66	50575202
Epstein-Barr virus associated lymphoproliferative disorder	18.86	12.08	12	29844	1677	50573591
Pulmonary alveolar haemorrhage	18.83	12.08	17	29839	4010	50571258
Bacillary angiomatosis	18.55	12.08	5	29851	72	50575196
Hypoaesthesia	18.53	12.08	29	29827	127228	50448040
Emphysematous pyelonephritis	18.38	12.08	6	29850	172	50575096
Smooth muscle cell neoplasm	18.32	12.08	9	29847	762	50574506
Irritable bowel syndrome	18.26	12.08	4	29852	51437	50523831
Constipation	18.13	12.08	53	29803	185655	50389613
Encephalitis cytomegalovirus	18.08	12.08	8	29848	534	50574734
Wheezing	18.04	12.08	7	29849	62040	50513228
Tuberculosis gastrointestinal	17.99	12.08	7	29849	337	50574931
Neutrophil count increased	17.96	12.08	31	29825	14164	50561104
Hypertriglyceridaemia	17.86	12.08	19	29837	5472	50569796
Bacteroides bacteraemia	17.84	12.08	4	29852	25	50575243
Glomerulosclerosis	17.79	12.08	7	29849	347	50574921
Hyperamylasaemia	17.76	12.08	7	29849	349	50574919
Acute motor axonal neuropathy	17.70	12.08	4	29852	26	50575242
Fanconi syndrome	17.70	12.08	10	29846	1126	50574142
Red blood cells urine positive	17.69	12.08	14	29842	2761	50572507
Meningitis cryptococcal	17.63	12.08	10	29846	1135	50574133
Bacteraemia	17.58	12.08	31	29825	14402	50560866
Confusional state	17.48	12.08	54	29802	185874	50389394
New onset diabetes after transplantation	17.41	12.08	5	29851	92	50575176
Strongyloidiasis	17.40	12.08	9	29847	850	50574418
Urosepsis	17.29	12.08	32	29824	15433	50559835
COVID-19 pneumonia	17.28	12.08	23	29833	8372	50566896
Oesophageal ulcer	17.18	12.08	16	29840	3929	50571339
Sinusitis	17.14	12.08	48	29808	170510	50404758
Brain natriuretic peptide increased	17.14	12.08	17	29839	4510	50570758
Fibromyalgia	17.01	12.08	3	29853	44975	50530293
Disease recurrence	16.99	12.08	37	29819	20044	50555224
Gastrointestinal mucormycosis	16.85	12.08	6	29850	225	50575043
Nephropathy	16.76	12.08	18	29838	5240	50570028
Hepatic enzyme increased	16.70	12.08	35	29821	137345	50437923
Malacoplakia	16.61	12.08	5	29851	109	50575159
Disseminated tuberculosis	16.56	12.08	13	29843	2533	50572735
Acanthamoeba infection	16.56	12.08	4	29852	36	50575232
Scedosporium infection	16.45	12.08	7	29849	425	50574843
Joint tuberculosis	16.40	12.08	5	29851	114	50575154
Nephrotic syndrome	16.39	12.08	17	29839	4753	50570515
Purulent pericarditis	16.36	12.08	4	29852	38	50575230
Skin hypertrophy	16.35	12.08	14	29842	3081	50572187
Biopsy kidney	16.20	12.08	5	29851	119	50575149
Cardiac murmur functional	16.18	12.08	4	29852	40	50575228
Pneumonia	16.15	12.08	313	29543	378088	50197180
Neuropathy peripheral	16.13	12.08	20	29836	96737	50478531
Drug resistance	16.08	12.08	35	29821	18954	50556314
Pancreatitis necrotising	16.08	12.08	10	29846	1343	50573925
Orbital apex syndrome	16	12.08	4	29852	42	50575226
Epstein-Barr virus associated lymphoma	15.89	12.08	7	29849	462	50574806
Influenza like illness	15.87	12.08	7	29849	57452	50517816
Acute pulmonary histoplasmosis	15.56	12.08	5	29851	136	50575132
Graft versus host disease in liver	15.54	12.08	7	29849	487	50574781
Colitis	15.47	12.08	54	29802	38475	50536793
Cytomegalovirus gastrointestinal infection	15.44	12.08	6	29850	288	50574980
Necrotising retinitis	15.26	12.08	6	29850	297	50574971
Meningitis histoplasma	15.16	12.08	3	29853	9	50575259
Renal disorder	15.14	12.08	43	29813	27462	50547806
Mycobacterium abscessus infection	15.06	12.08	7	29849	524	50574744
Mobility decreased	15	12.08	15	29841	79933	50495335
Urticaria	14.92	12.08	34	29822	129527	50445741
Renal necrosis	14.82	12.08	4	29852	58	50575210
B-cell lymphoma	14.75	12.08	13	29843	2972	50572296
Therapy cessation	14.65	12.08	41	29815	25970	50549298
Cardiac failure congestive	14.54	12.08	17	29839	84365	50490903
Graft versus host disease in eye	14.45	12.08	4	29852	64	50575204
Mucocutaneous leishmaniasis	14.41	12.08	6	29850	345	50574923
Hepatic echinococciasis	14.29	12.08	3	29853	13	50575255
Graft versus host disease in lung	14.29	12.08	6	29850	352	50574916
Bacterial colitis	14.17	12.08	4	29852	69	50575199
Lung diffusion test decreased	14.15	12.08	7	29849	602	50574666
Pneumonia fungal	14.14	12.08	15	29841	4305	50570963
Cytomegalovirus infection reactivation	14.10	12.08	12	29844	2619	50572649
Anorexia nervosa	14.05	12.08	5	29851	187	50575081
Leiomyosarcoma	14	12.08	5	29851	189	50575079
Pathogen resistance	13.94	12.08	17	29839	5672	50569596
Herpes simplex	13.79	12.08	19	29837	7143	50568125
Normocytic anaemia	13.76	12.08	9	29847	1318	50573950
Bronchiectasis	13.72	12.08	23	29833	10260	50565008
Transplant	13.72	12.08	7	29849	643	50574625
Anaemia	13.69	12.08	217	29639	252239	50323029
Gastroenteritis cryptosporidial	13.66	12.08	4	29852	79	50575189
Mycoplasma infection	13.62	12.08	6	29850	396	50574872
Product monitoring error	13.58	12.08	12	29844	2752	50572516
Anuria	13.50	12.08	24	29832	11220	50564048
Histoplasmosis cutaneous	13.34	12.08	3	29853	19	50575249
Pulmonary function test decreased	13.34	12.08	13	29843	3375	50571893
Immunosuppression	13.26	12.08	19	29837	7407	50567861
Pulmonary mucormycosis	13.26	12.08	5	29851	221	50575047
Oesophageal stenosis	13.24	12.08	12	29844	2846	50572422
Myocardial infarction	13.23	12.08	20	29836	89007	50486261
Aphthous ulcer	13.22	12.08	23	29833	10574	50564694
Nephrostomy	13.21	12.08	4	29852	89	50575179
Chronic graft versus host disease	13.21	12.08	12	29844	2855	50572413
Lymphoproliferative disorder	13.17	12.08	12	29844	2865	50572403
Hyperuricaemia	13.15	12.08	15	29841	4665	50570603
Intentional product use issue	13.13	12.08	84	29772	76834	50498434
Gait disturbance	13.10	12.08	45	29811	149960	50425308
Extremity necrosis	12.92	12.08	9	29847	1462	50573806
Organising pneumonia	12.91	12.08	15	29841	4759	50570509
Urinary tract infection bacterial	12.84	12.08	14	29842	4145	50571123
Injection site bruising	12.76	12.08	3	29853	36765	50538503
Bone marrow granuloma	12.73	12.08	3	29853	24	50575244
Sterile pyuria	12.73	12.08	3	29853	24	50575244
Neuroendocrine carcinoma of the skin	12.70	12.08	6	29850	466	50574802
Squamous cell carcinoma	12.66	12.08	19	29837	7720	50567548
Hepatic cyst infection	12.66	12.08	4	29852	103	50575165
Bacterial sepsis	12.64	12.08	13	29843	3599	50571669
Asthenia	12.54	12.08	124	29732	318918	50256350
Fungaemia	12.50	12.08	10	29846	2002	50573266
Weight increased	12.48	12.08	69	29787	201822	50373446
Eye infection viral	12.48	12.08	4	29852	108	50575160
Fungal sepsis	12.39	12.08	8	29848	1146	50574122
Cystitis viral	12.38	12.08	4	29852	111	50575157
Dry skin	12.35	12.08	5	29851	43186	50532082
Poikilocytosis	12.31	12.08	4	29852	113	50575155
Renal haemorrhage	12.26	12.08	7	29849	804	50574464
Genital herpes	12.20	12.08	9	29847	1598	50573670
Superinfection bacterial	12.20	12.08	6	29850	509	50574759
Necrotising fasciitis	12.19	12.08	11	29845	2593	50572675
Wrong technique in product usage process	12.13	12.08	9	29847	55501	50519767
Pneumonia haemophilus	12.08	12.08	6	29850	520	50574748

FDA Adverse Event Reporting System (Male)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Kidney transplant rejection	673.95	12.56	271	35989	6734	29531533
Cytomegalovirus infection	575.86	12.56	357	35903	22858	29515409
Transplant rejection	511.67	12.56	242	36018	8970	29529297
Complications of transplanted kidney	429.30	12.56	167	36093	3787	29534480
COVID-19	395.29	12.56	338	35922	35676	29502591
Polyomavirus-associated nephropathy	308.01	12.56	126	36134	3270	29534997
Post transplant lymphoproliferative disorder	252.92	12.56	127	36133	5366	29532901
Immunosuppressant drug level increased	251.74	12.56	121	36139	4644	29533623
BK virus infection	250.11	12.56	120	36140	4587	29533680
Transplant dysfunction	222.28	12.56	89	36171	2181	29536086
Hepatitis E	207.87	12.56	78	36182	1596	29536671
Renal transplant failure	199.46	12.56	66	36194	917	29537350
Thrombotic microangiopathy	193.75	12.56	125	36135	8556	29529711
Blood creatinine increased	191.09	12.56	360	35900	84742	29453525
Cytomegalovirus viraemia	163.63	12.56	100	36160	6220	29532047
Leukopenia	158.12	12.56	260	36000	54943	29483324
West Nile viral infection	149.54	12.56	48	36212	602	29537665
Delayed graft function	146.27	12.56	63	36197	1864	29536403
JC virus infection	140.65	12.56	61	36199	1836	29536431
Aspergillus infection	140.39	12.56	111	36149	10470	29527797
Product use in unapproved indication	138.06	12.56	319	35941	86556	29451711
Parvovirus B19 infection	136.52	12.56	46	36214	678	29537589
Transplant failure	122.62	12.56	63	36197	2793	29535474
Nephropathy toxic	122.01	12.56	103	36157	10653	29527614
Incision site pain	115.02	12.56	52	36208	1731	29536536
Epstein-Barr virus infection	108.86	12.56	79	36181	6550	29531717
Cryptococcosis	107.44	12.56	51	36209	1901	29536366
Mucormycosis	107.08	12.56	71	36189	5087	29533180
Drug level increased	106.22	12.56	123	36137	18664	29519603
Renal tubular atrophy	102.55	12.56	41	36219	1000	29537267
Nocardiosis	101.18	12.56	58	36202	3202	29535065
Kidney fibrosis	99.15	12.56	49	36211	1998	29536269
Bronchopulmonary aspergillosis	96.57	12.56	96	36164	12248	29526019
Phaeohyphomycosis	94.70	12.56	36	36224	764	29537503
Pseudomonas infection	91.63	12.56	88	36172	10764	29527503
COVID-19 pneumonia	91.54	12.56	83	36177	9439	29528828
Fall	91.26	12.56	52	36208	177126	29361141
Chronic allograft nephropathy	89.57	12.56	38	36222	1082	29537185
Apoptosis	82.13	12.56	24	36236	214	29538053
Proteinuria	78.69	12.56	97	36163	15707	29522560
Off label use	75.48	12.56	627	35633	300173	29238094
Lymphocyte count decreased	75.33	12.56	105	36155	19166	29519101
Fatigue	74.54	12.56	175	36085	316646	29221621
Klebsiella infection	74.48	12.56	66	36194	7283	29530984
Strongyloidiasis	74.08	12.56	42	36218	2270	29535997
Renal impairment	72.55	12.56	242	36018	81091	29457176
Renal artery stenosis	72.09	12.56	39	36221	1922	29536345
Rash	70.90	12.56	77	36183	189742	29348525
Malacoplakia	70.88	12.56	19	36241	119	29538148
Lymphocele	70.87	12.56	34	36226	1298	29536969
Focal segmental glomerulosclerosis	69.40	12.56	37	36223	1770	29536497
Enterococcal infection	67.83	12.56	66	36194	8202	29530065
Blastomycosis	67.53	12.56	22	36238	290	29537977
Cystitis haemorrhagic	66.81	12.56	52	36208	4790	29533477
Pulmonary nocardiosis	65.27	12.56	25	36235	542	29537725
Septic shock	64.78	12.56	196	36064	62364	29475903
Acute kidney injury	64.36	12.56	549	35711	264718	29273549
Histoplasmosis	64.31	12.56	32	36228	1324	29536943
Pneumonia cryptococcal	64.29	12.56	27	36233	749	29537518
Liver transplant rejection	63.62	12.56	36	36224	1938	29536329
Pneumocystis jirovecii pneumonia	63.47	12.56	90	36170	16689	29521578
Graft loss	61.99	12.56	27	36233	821	29537446
Aplasia pure red cell	61.07	12.56	52	36208	5439	29532828
Pneumonia cytomegaloviral	60.76	12.56	39	36221	2643	29535624
Acinetobacter infection	60.25	12.56	28	36232	994	29537273
Pain	60.25	12.56	73	36187	171359	29366908
Red blood cells urine positive	57.98	12.56	32	36228	1641	29536626
Progressive multifocal leukoencephalopathy	57.71	12.56	62	36198	8657	29529610
Encephalitis viral	57.52	12.56	28	36232	1104	29537163
Malignant neoplasm progression	56.45	12.56	11	36249	73848	29464419
Infection reactivation	55.57	12.56	27	36233	1060	29537207
Diabetes mellitus	55.35	12.56	139	36121	39692	29498575
Urinary tract infection	54.77	12.56	204	36056	72150	29466117
Rhodococcus infection	53.85	12.56	16	36244	152	29538115
Cytomegalovirus colitis	53.71	12.56	35	36225	2434	29535833
Pruritus	53.67	12.56	39	36221	116810	29421457
Dizziness	52.77	12.56	95	36165	189589	29348678
Polyomavirus viraemia	51.83	12.56	22	36238	627	29537640
Renal tubular necrosis	51.53	12.56	75	36185	14240	29524027
Depression	51.44	12.56	20	36240	85127	29453140
Posterior reversible encephalopathy syndrome	51.11	12.56	59	36201	8917	29529350
Cryptosporidiosis infection	50.21	12.56	19	36241	398	29537869
Neutrophil count increased	49.84	12.56	75	36185	14667	29523600
Adenovirus infection	49.22	12.56	42	36218	4405	29533862
Scedosporium infection	47.81	12.56	22	36238	763	29537504
Disseminated cryptococcosis	47.73	12.56	25	36235	1153	29537114
Alternaria infection	47.11	12.56	17	36243	310	29537957
Graft versus host disease in lung	46.82	12.56	19	36241	482	29537785
Haemophagocytic lymphohistiocytosis	46.79	12.56	61	36199	10443	29527824
Acanthamoeba infection	46.58	12.56	18	36242	400	29537867
Acute respiratory distress syndrome	46.42	12.56	93	36167	22842	29515425
Ureteric stenosis	46.12	12.56	24	36236	1092	29537175
Graft versus host disease in skin	45.99	12.56	36	36224	3343	29534924
Arthralgia	45.37	12.56	63	36197	139554	29398713
Protein urine present	45.28	12.56	41	36219	4653	29533614
Constipation	45.18	12.56	44	36216	114116	29424151
Brain abscess	44.40	12.56	32	36228	2623	29535644
Gastroenteritis norovirus	43.76	12.56	25	36235	1371	29536896
Syncope	43.10	12.56	23	36237	81348	29456919
Hydronephrosis	42.51	12.56	53	36207	8677	29529590
Graft versus host disease	41.47	12.56	55	36205	9573	29528694
Graft versus host disease in gastrointestinal tract	40.69	12.56	33	36227	3225	29535042
Escherichia urinary tract infection	40.55	12.56	32	36228	3007	29535260
Trichodysplasia spinulosa	39.87	12.56	14	36246	235	29538032
Basal cell carcinoma	39.66	12.56	73	36187	16837	29521430
American trypanosomiasis	39.59	12.56	14	36246	240	29538027
Escherichia infection	39.42	12.56	45	36215	6719	29531548
Lymphopenia	39.02	12.56	64	36196	13469	29524798
Diffuse large B-cell lymphoma	38.70	12.56	43	36217	6233	29532034
Anxiety	38.52	12.56	29	36231	85336	29452931
Drug hypersensitivity	38.23	12.56	18	36242	68388	29469879
Hyperhidrosis	37.61	12.56	16	36244	64524	29473743
Epstein-Barr viraemia	37.49	12.56	20	36240	958	29537309
Dermatophytosis	37.48	12.56	13	36247	210	29538057
Blood urea increased	36.86	12.56	96	36164	28016	29510251
Squamous cell carcinoma	35.86	12.56	53	36207	10198	29528069
Pancreas transplant rejection	35.79	12.56	12	36248	174	29538093
Viraemia	35.73	12.56	20	36240	1054	29537213
Intraductal papillary mucinous neoplasm	35.62	12.56	14	36246	326	29537941
Urinoma	35.17	12.56	12	36248	184	29538083
Pyelonephritis	35.08	12.56	38	36222	5355	29532912
Dyspnoea	34.97	12.56	246	36014	326486	29211781
Papilloma viral infection	34.84	12.56	15	36245	443	29537824
Histoplasmosis disseminated	34.56	12.56	20	36240	1124	29537143
Renal tubular injury	34.49	12.56	17	36243	689	29537578
Acute graft versus host disease	34.37	12.56	39	36221	5785	29532482
Coronavirus infection	34.25	12.56	30	36230	3258	29535009
Smooth muscle cell neoplasm	34.05	12.56	11	36249	141	29538126
Histology abnormal	33.93	12.56	13	36247	282	29537985
Malacoplakia gastrointestinal	33.66	12.56	10	36250	95	29538172
Decreased appetite	33.46	12.56	81	36179	145261	29393006
Somnolence	32.96	12.56	40	36220	93915	29444352
Respiratory failure	32.43	12.56	217	36043	96914	29441353
Candida infection	32.33	12.56	63	36197	15162	29523105
Chronic graft versus host disease in skin	32.02	12.56	17	36243	806	29537461
Chronic graft versus host disease in liver	31.96	12.56	13	36247	332	29537935
Squamous cell carcinoma of skin	31.69	12.56	48	36212	9438	29528829
Chronic obstructive pulmonary disease	31.49	12.56	6	36254	40949	29497318
Trichophytosis	31.25	12.56	12	36248	262	29538005
Renal transplant	30.54	12.56	21	36239	1597	29536670
Graft versus host disease in liver	30.21	12.56	18	36242	1068	29537199
Mycobacterial infection	30.20	12.56	22	36238	1834	29536433
Varicella zoster virus infection	29.97	12.56	20	36240	1448	29536819
Myocardial infarction	29.95	12.56	56	36204	110240	29428027
Meningitis cryptococcal	29.95	12.56	23	36237	2077	29536190
Necrotising oesophagitis	29.84	12.56	14	36246	508	29537759
Epistaxis	29.83	12.56	13	36247	51691	29486576
Donor specific antibody present	29.79	12.56	9	36251	91	29538176
Pyelonephritis acute	29.78	12.56	21	36239	1663	29536604
Immune reconstitution inflammatory syndrome	29.72	12.56	42	36218	7760	29530507
Febrile neutropenia	29.59	12.56	58	36202	112182	29426085
Large intestinal ulcer	29.50	12.56	21	36239	1688	29536579
Heart transplant rejection	29.24	12.56	18	36242	1133	29537134
Intentional product misuse	29.06	12.56	4	36256	34657	29503610
Erythema	28.91	12.56	30	36230	75576	29462691
Postoperative thoracic procedure complication	28.71	12.56	7	36253	28	29538239
Cardiac failure congestive	28.59	12.56	31	36229	76550	29461717
Neutrophil count decreased	28.42	12.56	9	36251	43558	29494709
Pneumonia escherichia	27.95	12.56	12	36248	352	29537915
Rectal prolapse	27.83	12.56	11	36249	260	29538007
Meningoencephalitis amoebic	27.74	12.56	9	36251	117	29538150
Isosporiasis	27.72	12.56	8	36252	68	29538199
Hernial eventration	27.72	12.56	8	36252	68	29538199
Asthenia	27.67	12.56	153	36107	215097	29323170
Coronary artery disease	27.31	12.56	10	36250	44180	29494087
Gastroenteritis sapovirus	27.07	12.56	9	36251	127	29538140
Epstein-Barr virus associated lymphoproliferative disorder	26.92	12.56	20	36240	1718	29536549
Renal cyst haemorrhage	26.72	12.56	12	36248	393	29537874
Malaise	26.70	12.56	103	36157	159499	29378768
Acute myocardial infarction	26.67	12.56	13	36247	48425	29489842
Cerebral aspergillosis	26.54	12.56	18	36242	1338	29536929
Hypersensitivity	26.50	12.56	16	36244	52887	29485380
Vena cava injury	26.49	12.56	10	36250	208	29538059
Ventricular remodelling	26.29	12.56	8	36252	83	29538184
Neuropathy peripheral	26.24	12.56	29	36231	70998	29467269
Nausea	26.14	12.56	228	36032	289027	29249240
SARS-CoV-2 antibody test positive	25.84	12.56	10	36250	223	29538044
Anogenital warts	25.81	12.56	13	36247	552	29537715
Renal vein thrombosis	25.74	12.56	9	36251	149	29538118
Human herpesvirus 6 infection	25.68	12.56	20	36240	1843	29536424
Chronic graft versus host disease	25.52	12.56	28	36232	4001	29534266
Wrong technique in product usage process	25.49	12.56	4	36256	31424	29506843
Urticaria	25.39	12.56	18	36242	54642	29483625
Transplantation complication	25.32	12.56	8	36252	95	29538172
Actinic keratosis	25.19	12.56	27	36233	3759	29534508
Renal graft infection	25.16	12.56	10	36250	240	29538027
Glomerulonephritis	25.08	12.56	19	36241	1681	29536586
Encephalitis	25.06	12.56	35	36225	6395	29531872
Hypotension	25.05	12.56	138	36122	194216	29344051
Perinephric collection	25.00	12.56	9	36251	163	29538104
Non-cirrhotic portal hypertension	24.93	12.56	10	36250	246	29538021
Gastrointestinal mucormycosis	24.52	12.56	8	36252	106	29538161
Drug interaction	24.38	12.56	358	35902	197027	29341240
Procedural pain	24.33	12.56	28	36232	4216	29534051
Immunosuppressant drug level decreased	24.18	12.56	16	36244	1142	29537125
Hyperkalaemia	24.11	12.56	143	36117	61249	29477018
Foetal exposure during pregnancy	23.93	12.56	6	36254	33861	29504406
Blood pressure decreased	23.85	12.56	13	36247	45464	29492803
Diarrhoea	23.80	12.56	554	35706	332144	29206123
Cholangitis	23.58	12.56	37	36223	7500	29530767
Muscle spasms	23.58	12.56	27	36233	65055	29473212
Glomerulonephritis membranoproliferative	23.55	12.56	11	36249	395	29537872
Joint swelling	23.50	12.56	16	36244	49614	29488653
Mycobacterium haemophilum infection	23.36	12.56	6	36254	31	29538236
Cytomegalovirus oesophagitis	23.29	12.56	11	36249	405	29537862
Meningoencephalitis viral	23.19	12.56	8	36252	127	29538140
Urinary tract infection bacterial	23.08	12.56	17	36243	1441	29536826
Cardio-respiratory arrest	23.06	12.56	17	36243	50584	29487683
Inappropriate schedule of product administration	22.91	12.56	13	36247	44459	29493808
Corynebacterium infection	22.90	12.56	11	36249	421	29537846
Vesicoureteral reflux surgery	22.82	12.56	4	36256	0	29538267
Myopathy toxic	22.78	12.56	11	36249	426	29537841
Postoperative wound infection	22.71	12.56	27	36233	4209	29534058
Seroma	22.57	12.56	12	36248	571	29537696
Parvovirus infection	22.50	12.56	11	36249	438	29537829
Fungal infection	22.49	12.56	51	36209	13634	29524633
Insomnia	22.42	12.56	47	36213	88714	29449553
Nasal cavity cancer	22.37	12.56	8	36252	142	29538125
Haemolytic uraemic syndrome	22.36	12.56	19	36241	1981	29536286
Blood creatine phosphokinase increased	22.23	12.56	11	36249	40633	29497634
Bacterial infection	22.12	12.56	49	36211	12899	29525368
Pain in extremity	22.04	12.56	66	36194	110367	29427900
Disseminated mucormycosis	22.03	12.56	10	36250	336	29537931
Renal tubular acidosis	21.96	12.56	18	36242	1785	29536482
Philadelphia positive chronic myeloid leukaemia	21.86	12.56	7	36253	87	29538180
Aortic pseudoaneurysm	21.81	12.56	6	36254	42	29538225
Bacterial pyelonephritis	21.66	12.56	9	36251	243	29538024
Catatonia	21.55	12.56	27	36233	4441	29533826
Cutaneous malacoplakia	21.45	12.56	6	36254	45	29538222
International normalised ratio increased	21.42	12.56	14	36246	44358	29493909
Histoplasmosis cutaneous	21.14	12.56	5	36255	17	29538250
Pneumonia pseudomonal	21.10	12.56	23	36237	3264	29535003
Pneumocystis jirovecii infection	20.96	12.56	16	36244	1432	29536835
Human herpesvirus 8 infection	20.89	12.56	13	36247	834	29537433
Tubulointerstitial nephritis	20.86	12.56	58	36202	17585	29520682
Infective aortitis	20.71	12.56	5	36255	19	29538248
Musculoskeletal stiffness	20.70	12.56	10	36250	37448	29500819
Metastatic squamous cell carcinoma	20.67	12.56	10	36250	389	29537878
Seizure	20.55	12.56	53	36207	93070	29445197
Infected lymphocele	20.50	12.56	5	36255	20	29538247
Back pain	20.50	12.56	61	36199	102223	29436044
Product dose omission issue	20.41	12.56	56	36204	96327	29441940
Asthma	20.35	12.56	8	36252	33841	29504426
Lung transplant	20.28	12.56	17	36243	1739	29536528
Pathogen resistance	20.25	12.56	36	36224	8080	29530187
Lung transplant rejection	20.14	12.56	12	36248	712	29537555
Leishmaniasis	20.06	12.56	9	36251	294	29537973
Necrotising fasciitis fungal	19.94	12.56	5	36255	23	29538244
Prophylaxis against transplant rejection	19.94	12.56	5	36255	23	29538244
Paraesthesia	19.87	12.56	22	36238	53823	29484444
Platelet count decreased	19.86	12.56	64	36196	104608	29433659
Hypoglycaemia	19.85	12.56	18	36242	48328	29489939
Anti-erythropoietin antibody negative	19.71	12.56	8	36252	203	29538064
Drug reaction with eosinophilia and systemic symptoms	19.70	12.56	5	36255	27987	29510280
Intra-abdominal haemorrhage	19.62	12.56	18	36242	2077	29536190
Suicidal ideation	19.60	12.56	9	36251	34707	29503560
Disease recurrence	19.49	12.56	53	36207	15861	29522406
Electrocardiogram QT prolonged	19.44	12.56	10	36250	36127	29502140
Alveolar proteinosis	19.43	12.56	9	36251	317	29537950
Optic discs blurred	19.24	12.56	6	36254	68	29538199
Metabolic acidosis	19.03	12.56	94	36166	37568	29500699
Suicide attempt	19.01	12.56	9	36251	34101	29504166
Chest pain	18.88	12.56	72	36188	111901	29426366
Mediastinitis	18.81	12.56	11	36249	630	29537637
Depressed level of consciousness	18.74	12.56	11	36249	36931	29501336
Urosepsis	18.73	12.56	41	36219	10705	29527562
Cytomegalovirus mucocutaneous ulcer	18.71	12.56	6	36254	75	29538192
Secondary immunodeficiency	18.70	12.56	9	36251	346	29537921
Mouth ulceration	18.61	12.56	40	36220	10315	29527952
Post procedural urine leak	18.52	12.56	7	36253	146	29538121
Impaired healing	18.49	12.56	47	36213	13511	29524756
Hemianopia heteronymous	18.43	12.56	5	36255	33	29538234
Heart rate decreased	18.42	12.56	4	36256	24908	29513359
IgA nephropathy	18.26	12.56	13	36247	1045	29537222
Visceral leishmaniasis	18.24	12.56	10	36250	506	29537761
Neurotoxicity	18.23	12.56	49	36211	14564	29523703
Feeling abnormal	18.23	12.56	24	36236	54421	29483846
Periostitis	18.19	12.56	8	36252	249	29538018
Anorectal varices	18.17	12.56	5	36255	35	29538232
Enterobacter infection	18.13	12.56	17	36243	2017	29536250
Complications of transplanted heart	18.04	12.56	8	36252	254	29538013
Haemoglobinaemia	17.97	12.56	7	36253	159	29538108
Disseminated varicella zoster virus infection	17.97	12.56	7	36253	159	29538108
Eccrine squamous syringometaplasia	17.93	12.56	5	36255	37	29538230
Acute graft versus host disease in intestine	17.92	12.56	18	36242	2323	29535944
Acute graft versus host disease in skin	17.60	12.56	25	36235	4639	29533628
Fungal skin infection	17.56	12.56	18	36242	2380	29535887
Incisional hernia	17.54	12.56	13	36247	1113	29537154
Aggression	17.45	12.56	11	36249	35530	29502737
Bacterial sepsis	17.44	12.56	25	36235	4678	29533589
Hyperparathyroidism	17.42	12.56	13	36247	1124	29537143
Acinetobacter bacteraemia	17.29	12.56	6	36254	97	29538170
Retinal artery occlusion	17.29	12.56	15	36245	1608	29536659
Transmission of an infectious agent via transplant	17.29	12.56	4	36256	12	29538255
Delusion of grandeur	17.12	12.56	9	36251	418	29537849
Ureteral catheterisation	17.12	12.56	3	36257	0	29538267
Biliary anastomosis complication	17.01	12.56	6	36254	102	29538165
Cardiac failure	16.83	12.56	46	36214	79241	29459026
Hallucination	16.79	12.56	18	36242	44694	29493573
Mycobacterium chelonae infection	16.71	12.56	10	36250	598	29537669
Balance disorder	16.68	12.56	12	36248	36158	29502109
End stage renal disease	16.62	12.56	32	36228	7632	29530635
Urinary fistula	16.60	12.56	6	36254	110	29538157
Nephrostomy	16.57	12.56	7	36253	197	29538070
Glomerulonephritis proliferative	16.47	12.56	7	36253	200	29538067
Multiple organ dysfunction syndrome	16.46	12.56	133	36127	62983	29475284
Loss of consciousness	16.45	12.56	42	36218	74014	29464253
Cytomegalovirus nephritis	16.25	12.56	6	36254	117	29538150
Pneumonia klebsiella	16.10	12.56	18	36242	2626	29535641
Renal lymphocele	16.09	12.56	5	36255	56	29538211
Diverticulum intestinal	16.06	12.56	20	36240	3270	29534997
Dysgeusia	16.05	12.56	4	36256	22670	29515597
Argentine haemorrhagic fever	16.02	12.56	4	36256	18	29538249
Gait disturbance	15.98	12.56	42	36218	73307	29464960
Oesophageal stenosis	15.98	12.56	14	36246	1521	29536746
Chronic hepatitis C	15.94	12.56	8	36252	337	29537930
Agitation	15.80	12.56	24	36236	51280	29486987
Respiratory arrest	15.70	12.56	6	36254	25827	29512440
Human polyomavirus infection	15.53	12.56	10	36250	681	29537586
Rhabdomyolysis	15.51	12.56	32	36228	60776	29477491
Staphylococcal infection	15.50	12.56	74	36186	29166	29509101
Upper gastrointestinal haemorrhage	15.26	12.56	4	36256	21910	29516357
Chronic kidney disease-mineral and bone disorder	15.25	12.56	8	36252	370	29537897
Lymphorrhoea	15.20	12.56	5	36255	68	29538199
Cardiac disorder	15.14	12.56	14	36246	37249	29501018
White blood cell count decreased	15.10	12.56	52	36208	83310	29454957
Pyrexia	15.06	12.56	460	35800	287162	29251105
Serratia infection	15.06	12.56	10	36250	718	29537549
Abdominal wall haemorrhage	15.05	12.56	7	36253	249	29538018
Balamuthia infection	15.04	12.56	3	36257	3	29538264
Propionibacterium infection	14.97	12.56	7	36253	252	29538015
Gastrointestinal mucosa hyperaemia	14.82	12.56	7	36253	258	29538009
Graft thrombosis	14.82	12.56	7	36253	258	29538009
Pupillary deformity	14.79	12.56	4	36256	26	29538241
Lymphadenitis fungal	14.58	12.56	3	36257	4	29538263
Epstein-Barr virus associated lymphoma	14.56	12.56	9	36251	571	29537696
Vocal cord thickening	14.54	12.56	4	36256	28	29538239
Cranial nerve paralysis	14.42	12.56	4	36256	29	29538238
Rheumatoid arthritis	14.39	12.56	11	36249	32141	29506126
Herpes zoster cutaneous disseminated	14.33	12.56	6	36254	165	29538102
Hospitalisation	14.29	12.56	101	36159	45887	29492380
Peripheral swelling	14.27	12.56	36	36224	63703	29474564
Injury	14.20	12.56	3	36257	19043	29519224
Flushing	14.19	12.56	9	36251	28983	29509284
New onset diabetes after transplantation	14.18	12.56	4	36256	31	29538236
Wound dehiscence	14.18	12.56	18	36242	2999	29535268
Bilirubin conjugated increased	14.18	12.56	18	36242	2999	29535268
Angioedema	14.18	12.56	11	36249	31904	29506363
Leuconostoc infection	14.18	12.56	3	36257	5	29538262
Arteriovenous fistula aneurysm	14.18	12.56	3	36257	5	29538262
Gastroenteritis cryptosporidial	14.17	12.56	6	36254	170	29538097
Brain compression	14.10	12.56	6	36254	172	29538095
Functional gastrointestinal disorder	14.07	12.56	15	36245	2075	29536192
Pancreas transplant	14.07	12.56	4	36256	32	29538235
Nephrosclerosis	14.05	12.56	10	36250	804	29537463
Hyperparathyroidism secondary	14.02	12.56	12	36248	1263	29537004
Herpes simplex hepatitis	14.02	12.56	5	36255	88	29538179
Neuroendocrine carcinoma of the skin	14.00	12.56	9	36251	611	29537656
Pyuria	13.80	12.56	9	36251	627	29537640
Legionella infection	13.77	12.56	8	36252	453	29537814
Immunoglobulin G4 related disease	13.76	12.56	4	36256	35	29538232
Abdominal wall abscess	13.72	12.56	8	36252	456	29537811
Oesophageal ulcer	13.71	12.56	18	36242	3102	29535165
Passenger lymphocyte syndrome	13.56	12.56	4	36256	37	29538230
Scleroderma	13.52	12.56	12	36248	1326	29536941
Drug level fluctuating	13.36	12.56	8	36252	479	29537788
Capillaritis	13.29	12.56	5	36255	103	29538164
Enterovirus infection	13.28	12.56	9	36251	668	29537599
Drug resistance	13.27	12.56	57	36203	21483	29516784
Confusional state	13.26	12.56	97	36163	127780	29410487
Endocarditis viral	13.23	12.56	3	36257	8	29538259
Transitional cell carcinoma	13.23	12.56	14	36246	1921	29536346
Nodular regenerative hyperplasia	13.21	12.56	9	36251	674	29537593
Cytomegalovirus gastroenteritis	13.21	12.56	6	36254	202	29538065
Bordetella infection	13.20	12.56	5	36255	105	29538162
Gingival hypertrophy	13.11	12.56	13	36247	1652	29536615
Drug withdrawal syndrome	13.07	12.56	3	36257	17981	29520286
Biopsy kidney abnormal	12.98	12.56	5	36255	110	29538157
Pneumonia proteus	12.97	12.56	3	36257	9	29538258
Small intestine gangrene	12.97	12.56	3	36257	9	29538258
Disease progression	12.96	12.56	54	36206	81862	29456405
Herpes zoster oticus	12.94	12.56	5	36255	111	29538156
Phaeohyphomycotic brain abscess	12.94	12.56	4	36256	44	29538223
Cytomegalovirus gastritis	12.94	12.56	6	36254	212	29538055
Cytomegalovirus syndrome	12.90	12.56	5	36255	112	29538155
Toxoplasmosis	12.87	12.56	11	36249	1156	29537111
Streptococcal endocarditis	12.85	12.56	4	36256	45	29538222
Superinfection bacterial	12.83	12.56	9	36251	707	29537560
Liver transplant	12.81	12.56	15	36245	2301	29535966
Stomatitis	12.79	12.56	16	36244	37097	29501170
Carotid arteriosclerosis	12.78	12.56	12	36248	1426	29536841
Stenotrophomonas infection	12.77	12.56	13	36247	1704	29536563
Narrow anterior chamber angle	12.74	12.56	5	36255	116	29538151
Chemical peritonitis	12.66	12.56	5	36255	118	29538149
Central nervous system lymphoma	12.63	12.56	9	36251	725	29537542
Cerebrovascular accident	12.60	12.56	50	36210	76861	29461406
Urine output decreased	12.57	12.56	32	36228	9206	29529061

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Cytomegalovirus infection	1119.03	11.27	587	58656	36612	64402877
Kidney transplant rejection	870.78	11.27	328	58915	9183	64430306
Transplant rejection	857.10	11.27	385	58858	17016	64422473
Post transplant lymphoproliferative disorder	664.77	11.27	270	58973	9274	64430215
Complications of transplanted kidney	599.36	11.27	215	59028	5220	64434269
COVID-19	593.38	11.27	486	58757	64654	64374835
Polyomavirus-associated nephropathy	511.43	11.27	186	59057	4702	64434787
Immunosuppressant drug level increased	407	11.27	176	59067	7083	64432406
BK virus infection	406.73	11.27	177	59066	7235	64432254
Thrombotic microangiopathy	374.17	11.27	217	59026	16438	64423051
Cytomegalovirus viraemia	337.01	11.27	175	59068	10653	64428836
Product use in unapproved indication	321.37	11.27	579	58664	176039	64263450
Delayed graft function	286.14	11.27	107	59136	2929	64436560
Epstein-Barr virus infection	262.82	11.27	156	59087	12332	64427157
Parvovirus B19 infection	261.41	11.27	80	59163	1159	64438330
Transplant dysfunction	260.55	11.27	126	59117	6582	64432907
Leukopenia	259.98	11.27	388	58855	100854	64338635
Blood creatinine increased	245.36	11.27	444	58799	135338	64304151
Renal transplant failure	239.35	11.27	80	59163	1560	64437929
Aspergillus infection	238.24	11.27	162	59081	16217	64423272
Off label use	218.71	11.27	1150	58093	631656	63807833
West Nile viral infection	205.40	11.27	62	59181	855	64438634
JC virus infection	193.49	11.27	83	59160	3272	64436217
Posterior reversible encephalopathy syndrome	191.68	11.27	163	59080	22783	64416706
Cryptococcosis	188.56	11.27	77	59166	2678	64436811
Renal impairment	175.74	11.27	385	58858	134632	64304857
Pneumocystis jirovecii pneumonia	169.41	11.27	165	59078	27469	64412020
Drug level increased	162.36	11.27	178	59065	34018	64405471
Nephropathy toxic	162.03	11.27	132	59111	17382	64422107
Phaeohyphomycosis	155.18	11.27	52	59191	1022	64438467
Chronic allograft nephropathy	152.12	11.27	56	59187	1465	64438024
Apoptosis	151.70	11.27	39	59204	283	64439206
Incision site pain	147.61	11.27	64	59179	2590	64436899
Bronchopulmonary aspergillosis	144.11	11.27	128	59115	18957	64420532
Fall	143.98	11.27	104	59139	416722	64022767
Nocardiosis	142.48	11.27	75	59168	4692	64434797
Pain	142.43	11.27	180	59063	553331	63886158
Fatigue	140.12	11.27	300	58943	748430	63691059
Mucormycosis	137.20	11.27	85	59158	7256	64432233
Acute kidney injury	136.93	11.27	790	58453	448450	63991039
Graft versus host disease in skin	134.40	11.27	75	59168	5272	64434217
Histoplasmosis	133.23	11.27	55	59188	1967	64437522
Epstein-Barr viraemia	129.08	11.27	52	59191	1745	64437744
Graft versus host disease in gastrointestinal tract	128.34	11.27	74	59169	5538	64433951
Histoplasmosis disseminated	127.10	11.27	53	59190	1945	64437544
Lymphocele	126.61	11.27	50	59193	1591	64437898
Focal segmental glomerulosclerosis	125.61	11.27	59	59184	2885	64436604
Pseudomonas infection	123.36	11.27	114	59129	17769	64421720
Graft loss	123.03	11.27	43	59200	964	64438525
Blastomycosis	121.92	11.27	36	59207	458	64439031
Trichodysplasia spinulosa	120.89	11.27	39	59204	677	64438812
Adenovirus infection	120.59	11.27	78	59165	7177	64432312
Transplant failure	119.99	11.27	62	59181	3732	64435757
Varicella zoster virus infection	118.56	11.27	62	59181	3826	64435663
Klebsiella infection	118.46	11.27	98	59145	13183	64426306
Renal tubular atrophy	115.92	11.27	46	59197	1483	64438006
Aplasia pure red cell	115.58	11.27	75	59168	6939	64432550
Kidney fibrosis	113.68	11.27	56	59187	3045	64436444
Liver transplant rejection	112.45	11.27	55	59188	2944	64436545
Cytomegalovirus colitis	112.31	11.27	60	59183	3868	64435621
Arthralgia	111.40	11.27	146	59097	442114	63997375
Escherichia infection	109.13	11.27	99	59144	15069	64424420
Polyomavirus viraemia	106.03	11.27	40	59203	1122	64438367
Hepatitis E	104.59	11.27	49	59194	2382	64437107
Rash	104.01	11.27	163	59080	458386	63981103
Septic shock	102.91	11.27	269	58974	105168	64334321
Cystitis haemorrhagic	102.36	11.27	73	59170	7883	64431606
Enterococcal infection	100.73	11.27	91	59152	13775	64425714
COVID-19 pneumonia	100.12	11.27	98	59145	16406	64423083
Diabetes mellitus	99.71	11.27	201	59042	66273	64373216
Proteinuria	97.84	11.27	124	59119	27599	64411890
Diffuse large B-cell lymphoma	97.75	11.27	79	59164	10282	64429207
Progressive multifocal leukoencephalopathy	97.30	11.27	101	59142	18131	64421358
Strongyloidiasis	93.44	11.27	49	59194	3041	64436448
Renal tubular necrosis	91.18	11.27	107	59136	22003	64417486
Disseminated cryptococcosis	91.13	11.27	39	59204	1528	64437961
Respiratory failure	91.04	11.27	340	58903	160843	64278646
Drug hypersensitivity	90.61	11.27	53	59190	237762	64201727
Malacoplakia	88.01	11.27	24	59219	224	64439265
Human herpesvirus 6 infection	87.25	11.27	54	59189	4600	64434889
Haemophagocytic lymphohistiocytosis	85.90	11.27	93	59150	17516	64421973
Multiple organ dysfunction syndrome	85.27	11.27	245	58998	101168	64338321
Pruritus	83.96	11.27	98	59145	312302	64127187
Rhodococcus infection	83.28	11.27	23	59220	226	64439263
Dizziness	83.02	11.27	169	59074	429994	64009495
Acute respiratory distress syndrome	82.85	11.27	137	59106	38798	64400691
Graft versus host disease	81.89	11.27	81	59162	13732	64425757
Pneumonia cytomegaloviral	80.47	11.27	50	59193	4289	64435200
Infection reactivation	78.43	11.27	38	59205	1992	64437497
Tubulointerstitial nephritis	77.14	11.27	117	59126	30792	64408697
Arthropathy	77.12	11.27	10	59233	120957	64318532
Neutrophil count increased	75.55	11.27	104	59139	25070	64414419
Brain abscess	74.57	11.27	47	59196	4134	64435355
Lymphocyte count decreased	74.53	11.27	134	59109	40565	64398924
Injection site pain	71.53	11.27	9	59234	111399	64328090
Protein urine present	71.48	11.27	62	59181	8894	64430595
Joint swelling	71.33	11.27	56	59187	215326	64224163
Hypersensitivity	70.37	11.27	47	59196	196405	64243084
Gastroenteritis norovirus	69.95	11.27	39	59204	2736	64436753
Pancreas transplant rejection	69.87	11.27	21	59222	285	64439204
Depression	69.58	11.27	41	59202	183250	64256239
Anxiety	69.26	11.27	51	59192	202598	64236891
Renal artery stenosis	67.49	11.27	39	59204	2930	64436559
Graft versus host disease in lung	67.34	11.27	26	59217	778	64438711
Encephalitis viral	67.05	11.27	36	59207	2344	64437145
Red blood cells urine positive	66.79	11.27	45	59198	4433	64435056
Scedosporium infection	65.71	11.27	29	59214	1225	64438264
Lymphopenia	65.28	11.27	98	59145	25559	64413930
Acanthamoeba infection	64.20	11.27	22	59221	464	64439025
Malignant neoplasm progression	63.75	11.27	13	59230	112858	64326631
Malacoplakia gastrointestinal	62.12	11.27	17	59226	161	64439328
Viraemia	61.92	11.27	34	59209	2315	64437174
Renal tubular injury	61.32	11.27	27	59216	1134	64438355
Intentional overdose	60.93	11.27	6	59237	89938	64349551
Pneumonia cryptococcal	59.64	11.27	27	59216	1212	64438277
Blood urea increased	58.59	11.27	127	59116	44026	64395463
Human polyomavirus infection	58.07	11.27	25	59218	994	64438495
Cryptosporidiosis infection	58.05	11.27	22	59221	625	64438864
Malaise	57.51	11.27	180	59063	396067	64043422
Central nervous system lymphoma	56.57	11.27	30	59213	1905	64437584
Alternaria infection	56.42	11.27	21	59222	567	64438922
Urinoma	56.39	11.27	16	59227	175	64439314
Drug interaction	56.15	11.27	543	58700	361540	64077949
Contraindicated product administered	55.79	11.27	15	59228	107814	64331675
American trypanosomiasis	55.61	11.27	18	59225	316	64439173
Ureaplasma infection	55.24	11.27	22	59221	716	64438773
Pulmonary nocardiosis	54.64	11.27	22	59221	737	64438752
Candida infection	54.43	11.27	101	59142	31318	64408171
Escherichia urinary tract infection	54.26	11.27	61	59182	11976	64427513
Synovitis	52.77	11.27	13	59230	99077	64340412
Haemolytic uraemic syndrome	51.97	11.27	37	59206	3984	64435505
Disseminated mucormycosis	51.90	11.27	19	59224	489	64439000
Mycobacterial infection	51.82	11.27	33	59210	2955	64436534
Infusion related reaction	50.46	11.27	46	59197	164421	64275068
Acinetobacter infection	50.20	11.27	30	59213	2399	64437090
Injection site erythema	49.91	11.27	4	59239	70796	64368693
Ureteric stenosis	49.82	11.27	24	59219	1242	64438247
Hydronephrosis	49.55	11.27	63	59180	14062	64425427
Papilloma viral infection	49.42	11.27	25	59218	1439	64438050
Dyspnoea	49.34	11.27	423	58820	718251	63721238
Pain in extremity	48.82	11.27	131	59112	302954	64136535
Constipation	48.64	11.27	85	59158	229252	64210237
Pyelonephritis	48.34	11.27	69	59174	17197	64422292
Graft versus host disease in liver	48.21	11.27	25	59218	1516	64437973
Acute graft versus host disease	47.88	11.27	50	59193	9034	64430455
Coronavirus infection	47.64	11.27	40	59203	5490	64433999
Post transplant distal limb syndrome	47.47	11.27	18	59225	512	64438977
Toxoplasmosis	47.45	11.27	29	59214	2415	64437074
Philadelphia positive chronic myeloid leukaemia	47.42	11.27	13	59230	124	64439365
Immunosuppressant drug level decreased	47.09	11.27	26	59217	1789	64437700
Renal transplant	47.07	11.27	28	59215	2220	64437269
Anogenital warts	46.53	11.27	20	59223	792	64438697
Syncope	46.13	11.27	46	59197	157589	64281900
Human ehrlichiosis	45.35	11.27	16	59227	369	64439120
Insomnia	45.05	11.27	70	59173	197766	64241723
Diarrhoea	44.64	11.27	920	58323	721784	63717705
Donor specific antibody present	44.63	11.27	14	59229	221	64439268
Dermatophytosis	44.52	11.27	16	59227	390	64439099
Meningitis cryptococcal	44.31	11.27	30	59213	2979	64436510
Angiosarcoma	43.88	11.27	16	59227	407	64439082
Rheumatoid arthritis	43.59	11.27	52	59191	164242	64275247
Epstein-Barr virus associated lymphoproliferative disorder	43.33	11.27	30	59213	3089	64436400
Bacterial pyelonephritis	43.31	11.27	17	59226	532	64438957
Squamous cell carcinoma of skin	43.30	11.27	54	59189	11822	64427667
Lung transplant rejection	42.79	11.27	22	59221	1310	64438179
Alveolar proteinosis	42.41	11.27	17	59226	563	64438926
Stomatitis	42.31	11.27	24	59219	109581	64329908
Smooth muscle cell neoplasm	42.09	11.27	19	59224	847	64438642
Therapeutic product effect decreased	42.09	11.27	27	59216	115324	64324165
End stage renal disease	42.04	11.27	50	59193	10425	64429064
Urticaria	41.95	11.27	44	59199	147273	64292216
Chronic graft versus host disease	41.34	11.27	39	59204	6237	64433252
Human herpesvirus 8 infection	41.19	11.27	20	59223	1053	64438436
Contusion	41.14	11.27	27	59216	113938	64325551
Encephalitis	40.86	11.27	54	59189	12517	64426972
Cardiac failure congestive	40.67	11.27	36	59207	130544	64308945
Heart transplant rejection	40.61	11.27	21	59222	1266	64438223
Myocardial infarction	40.36	11.27	56	59187	165765	64273724
Decreased appetite	39.91	11.27	129	59114	281160	64158329
Immune reconstitution inflammatory syndrome	39.66	11.27	53	59190	12417	64427072
Back pain	39.62	11.27	109	59134	250062	64189427
Trichophytosis	39.59	11.27	14	59229	325	64439164
Balance disorder	39.24	11.27	14	59229	83912	64355577
Urinary fistula	39.08	11.27	10	59233	71	64439418
Nausea	39.01	11.27	499	58744	785301	63654188
Asthenia	39.01	11.27	232	59011	427812	64011677
Urinary tract infection	38.68	11.27	353	58890	231243	64208246
Squamous cell carcinoma	38.20	11.27	55	59188	13814	64425675
Erythema	38.16	11.27	71	59172	186999	64252490
Glomerulonephritis	37.97	11.27	27	59216	2901	64436588
Intentional product misuse	37.50	11.27	10	59233	72285	64367204
Gastroenteritis sapovirus	37.18	11.27	11	59232	141	64439348
Peripheral swelling	37.09	11.27	86	59157	209067	64230422
Cytomegalovirus nephritis	37.03	11.27	11	59232	143	64439346
Feeling abnormal	36.82	11.27	41	59202	133561	64305928
Biopsy lung abnormal	36.76	11.27	11	59232	147	64439342
Enterobacter infection	36.61	11.27	29	59214	3667	64435822
Hypogammaglobulinaemia	36.22	11.27	46	59197	10253	64429236
Musculoskeletal stiffness	35.99	11.27	36	59207	123170	64316319
Chronic graft versus host disease in liver	35.83	11.27	15	59228	556	64438933
Hernial eventration	35.80	11.27	9	59234	59	64439430
Gastrointestinal mucormycosis	35.35	11.27	13	59230	339	64439150
Nasopharyngitis	35.26	11.27	80	59163	195993	64243496
Asthma	35.14	11.27	22	59221	95203	64344286
Oesophageal candidiasis	35.07	11.27	40	59203	7977	64431512
Pathogen resistance	34.93	11.27	50	59193	12493	64426996
Suicidal ideation	34.90	11.27	9	59234	66533	64372956
Hyperhidrosis	34.80	11.27	38	59205	124882	64314607
Chronic obstructive pulmonary disease	34.70	11.27	11	59232	71037	64368452
Drug resistance	34.66	11.27	90	59153	35012	64404477
Histoplasmosis cutaneous	34.35	11.27	8	59235	36	64439453
Neutrophil count decreased	34.22	11.27	14	59229	77182	64362307
Bacterial sepsis	33.97	11.27	38	59205	7419	64432070
Alopecia	33.69	11.27	63	59180	165627	64273862
Wrong technique in product usage process	33.68	11.27	9	59234	64965	64374524
Meningoencephalitis amoebic	33.60	11.27	10	59233	131	64439358
Chronic graft versus host disease in skin	33.57	11.27	19	59224	1372	64438117
Pneumocystis jirovecii infection	33.49	11.27	23	59220	2338	64437151
Necrotising oesophagitis	33.10	11.27	15	59228	675	64438814
Mycobacterium avium complex infection	32.91	11.27	28	59215	3912	64435577
Cerebral aspergillosis	32.64	11.27	20	59223	1673	64437816
Chronic kidney disease	32.50	11.27	122	59121	57797	64381692
Oesophageal ulcer	32.41	11.27	34	59209	6176	64433313
Herpes simplex hepatitis	32.39	11.27	13	59230	432	64439057
Wound	32.11	11.27	15	59228	76462	64363027
Stress	32.11	11.27	8	59235	60526	64378963
Pyelonephritis acute	32.10	11.27	31	59212	5103	64434386
Wheezing	32.03	11.27	17	59226	80562	64358927
Actinic keratosis	31.94	11.27	31	59212	5134	64434355
Renal cyst haemorrhage	31.91	11.27	13	59230	449	64439040
Intraductal papillary mucinous neoplasm	31.91	11.27	14	59229	583	64438906
Lung transplant	31.90	11.27	28	59215	4080	64435409
Epstein-Barr virus associated lymphoma	31.69	11.27	16	59227	917	64438572
Hospitalisation	31.64	11.27	145	59098	75062	64364427
Sepsis	31.59	11.27	337	58906	230004	64209485
Mycobacterium haemophilum infection	31.37	11.27	8	59235	56	64439433
Drug reaction with eosinophilia and systemic symptoms	31.12	11.27	6	59237	54211	64385278
Ventricular remodelling	30.88	11.27	9	59234	109	64439380
Discomfort	30.80	11.27	18	59225	80860	64358629
Renal lymphocele	30.66	11.27	9	59234	112	64439377
Disseminated tuberculosis	30.65	11.27	26	59217	3619	64435870
Osteoarthritis	30.59	11.27	10	59233	63326	64376163
Disseminated varicella zoster vaccine virus infection	30.51	11.27	9	59234	114	64439375
Injury	30.49	11.27	7	59236	55985	64383504
Disease recurrence	30.30	11.27	80	59163	31430	64408059
Urinary tract infection bacterial	30.29	11.27	30	59213	5091	64434398
Muscle spasms	30.12	11.27	52	59191	140971	64298518
Malacoplakia vesicae	30.00	11.27	8	59235	68	64439421
Heart rate decreased	29.75	11.27	7	59236	55060	64384429
Oesophageal stenosis	29.51	11.27	26	59217	3808	64435681
Chromoblastomycosis	29.50	11.27	8	59235	73	64439416
Injection site reaction	29.39	11.27	4	59239	46660	64392829
Hypoaesthesia	29.07	11.27	52	59191	139056	64300433
Perinephric collection	29.04	11.27	11	59232	312	64439177
Hypotension	28.91	11.27	218	59025	380756	64058733
Pneumopericardium	28.81	11.27	9	59234	140	64439349
Vena cava injury	28.79	11.27	10	59233	220	64439269
Obliterative bronchiolitis	28.76	11.27	22	59221	2643	64436846
Pyrexia	28.66	11.27	693	58550	557951	63881538
Staphylococcal infection	28.64	11.27	107	59136	50571	64388918
Somnolence	28.44	11.27	94	59149	203551	64235938
Fungal skin infection	28.44	11.27	29	59214	5096	64434393
Biloma	28.35	11.27	9	59234	148	64439341
Swelling	28.29	11.27	66	59177	160152	64279337
Microsporidia infection	28.25	11.27	14	59229	771	64438718
Respiratory arrest	28.11	11.27	7	59236	52978	64386511
Biliary anastomosis complication	28.02	11.27	9	59234	154	64439335
SARS-CoV-2 antibody test positive	28.01	11.27	10	59233	239	64439250
Escherichia pyelonephritis	27.90	11.27	12	59231	476	64439013
Cystitis viral	27.88	11.27	13	59230	625	64438864
Neuroendocrine carcinoma of the skin	27.70	11.27	15	59228	993	64438496
Large intestinal ulcer	27.51	11.27	26	59217	4167	64435322
Gastroenteritis cryptosporidial	27.40	11.27	10	59233	255	64439234
Pancytopenia	27.33	11.27	225	59018	143084	64296405
Cardio-respiratory arrest	27.32	11.27	30	59213	98363	64341126
Electrocardiogram QT prolonged	27.11	11.27	20	59223	79428	64360061
Prophylaxis against transplant rejection	26.97	11.27	7	59236	53	64439436
Atypical haemolytic uraemic syndrome	26.87	11.27	13	59230	679	64438810
Weight increased	26.79	11.27	103	59140	213245	64226244
Suicide attempt	26.76	11.27	16	59227	70991	64368498
Chemical peritonitis	26.73	11.27	10	59233	274	64439215
Chronic hepatitis C	26.67	11.27	12	59231	531	64438958
Paraesthesia	26.60	11.27	52	59191	134470	64305019
Isosporiasis	26.45	11.27	8	59235	111	64439378
Cerebral toxoplasmosis	26.40	11.27	18	59225	1808	64437681
Bacillary angiomatosis	26.34	11.27	9	59234	188	64439301
Cytomegalovirus syndrome	26.26	11.27	10	59233	288	64439201
Necrotising herpetic retinopathy	26.07	11.27	8	59235	117	64439372
Mouth ulceration	25.91	11.27	77	59166	32367	64407122
Bacterial infection	25.70	11.27	65	59178	24885	64414604
Confusional state	25.66	11.27	138	59105	261006	64178483
Complications of transplanted heart	25.66	11.27	10	59233	307	64439182
Neuropathy peripheral	25.41	11.27	43	59200	117482	64322007
Cytomegalovirus hepatitis	25.39	11.27	12	59231	595	64438894
Superinfection bacterial	25.38	11.27	15	59228	1175	64438314
Pneumonia escherichia	25.30	11.27	13	59230	773	64438716
Headache	25.17	11.27	339	58904	529128	63910361
Gait disturbance	25.06	11.27	78	59165	172077	64267412
Encephalitis cytomegalovirus	24.99	11.27	14	59229	991	64438498
Cutaneous malacoplakia	24.97	11.27	7	59236	73	64439416
Rectal prolapse	24.92	11.27	17	59226	1709	64437780
Pulmonary mucormycosis	24.90	11.27	13	59230	799	64438690
Haemoglobin decreased	24.71	11.27	281	58962	194782	64244707
Meningitis bacterial	24.54	11.27	19	59224	2324	64437165
Acute myocardial infarction	24.51	11.27	17	59226	69701	64369788
Injection site pruritus	24.40	11.27	3	59240	37823	64401666
Fungal infection	24.30	11.27	78	59165	34173	64405316
Metabolic acidosis	24.28	11.27	129	59114	70829	64368660
Sinusitis	24.28	11.27	62	59181	145866	64293623
Nephropathy	24.19	11.27	34	59209	8352	64431137
Flushing	24.10	11.27	22	59221	78626	64360863
Pneumonia pseudomonal	24.09	11.27	26	59217	4877	64434612
Lupus nephritis	23.97	11.27	19	59224	2405	64437084
Passenger lymphocyte syndrome	23.85	11.27	7	59236	87	64439402
Mycobacterium chelonae infection	23.85	11.27	18	59225	2119	64437370
Herpes simplex oesophagitis	23.84	11.27	9	59234	253	64439236
Product dose omission issue	23.82	11.27	95	59148	194652	64244837
Cat scratch disease	23.77	11.27	9	59234	255	64439234
Nasal cavity cancer	23.69	11.27	8	59235	161	64439328
Coccidioidomycosis	23.65	11.27	14	59229	1100	64438389
Periostitis	23.65	11.27	11	59232	526	64438963
Inappropriate schedule of product administration	23.63	11.27	30	59213	92256	64347233
Aortic pseudoaneurysm	23.52	11.27	6	59237	42	64439447
Urosepsis	23.21	11.27	58	59185	22036	64417453
Loss of consciousness	23.20	11.27	65	59178	148300	64291189
Blood pressure decreased	23.15	11.27	27	59216	86172	64353317
Infective aortitis	23.05	11.27	6	59237	46	64439443
Mobility decreased	22.93	11.27	27	59216	85813	64353676
Anti-erythropoietin antibody negative	22.86	11.27	9	59234	284	64439205
Postoperative wound infection	22.83	11.27	37	59206	10299	64429190
Human herpesvirus 6 encephalitis	22.80	11.27	10	59233	416	64439073
Epidermodysplasia verruciformis	22.74	11.27	8	59235	183	64439306
Hyperkalaemia	22.73	11.27	165	59078	100964	64338525
Corynebacterium infection	22.70	11.27	13	59230	960	64438529
Fibromyalgia	22.65	11.27	3	59240	35728	64403761
Loss of personal independence in daily activities	22.52	11.27	20	59223	72434	64367055
Renal tubular acidosis	22.52	11.27	20	59223	2959	64436530
Liver abscess	22.51	11.27	26	59217	5254	64434235
Chest pain	22.47	11.27	126	59117	235854	64203635
Acarodermatitis	22.35	11.27	14	59229	1218	64438271
Systemic candida	22.32	11.27	26	59217	5303	64434186
Cytomegalovirus oesophagitis	22.31	11.27	11	59232	599	64438890
Coronary artery disease	22.24	11.27	14	59229	60419	64379070
Hypoglycaemia	22.22	11.27	30	59213	89862	64349627
Metastatic squamous cell carcinoma	22.19	11.27	10	59233	444	64439045
Cytomegalovirus gastrointestinal infection	22.15	11.27	10	59233	446	64439043
Catatonia	22.14	11.27	31	59212	7589	64431900
Blister	22.14	11.27	25	59218	80942	64358547
Hyperuricaemia	21.86	11.27	36	59207	10155	64429334
Postoperative thoracic procedure complication	21.81	11.27	6	59237	58	64439431
Irritable bowel syndrome	21.73	11.27	4	59239	37365	64402124
Acute graft versus host disease in skin	21.59	11.27	29	59214	6826	64432663
Toxic epidermal necrolysis	21.57	11.27	4	59239	37162	64402327
Drug level fluctuating	21.35	11.27	11	59232	658	64438831
Leishmaniasis	21.34	11.27	9	59234	340	64439149
Spindle cell sarcoma	21.32	11.27	8	59235	221	64439268
Necrotising fasciitis fungal	21.20	11.27	5	59238	24	64439465
New onset diabetes after transplantation	21.11	11.27	7	59236	133	64439356
Acute graft versus host disease in intestine	21.09	11.27	21	59222	3588	64435901
Chronic kidney disease-mineral and bone disorder	21.06	11.27	10	59233	501	64438988
Pericarditis	20.99	11.27	16	59227	62500	64376989
Optic discs blurred	20.95	11.27	6	59237	68	64439421
Injection site bruising	20.93	11.27	4	59239	36369	64403120
Diabetic macroangiopathy	20.77	11.27	7	59236	140	64439349
Glomerulonephritis proliferative	20.71	11.27	9	59234	366	64439123
Cytomegalovirus infection reactivation	20.71	11.27	26	59217	5730	64433759
Necrotising fasciitis	20.68	11.27	25	59218	5301	64434188
Emotional distress	20.66	11.27	4	59239	36034	64403455
Drug dependence	20.64	11.27	3	59240	33309	64406180
Hyperparathyroidism secondary	20.37	11.27	17	59226	2313	64437176
Lymphadenitis fungal	20.32	11.27	4	59239	6	64439483
Depressed level of consciousness	20.31	11.27	27	59216	81409	64358080
Epistaxis	20.21	11.27	37	59206	98094	64341395
Meningoencephalitis viral	20.18	11.27	9	59234	390	64439099
Visceral leishmaniasis	20.13	11.27	12	59231	955	64438534
Dysgeusia	20.10	11.27	9	59234	47038	64392451
International normalised ratio increased	19.99	11.27	26	59217	79141	64360348
Complications of transplanted lung	19.90	11.27	9	59234	403	64439086
Renal graft infection	19.88	11.27	9	59234	404	64439085
Eccrine squamous syringometaplasia	19.86	11.27	5	59238	33	64439456
Hepatic fibrosis	19.85	11.27	25	59218	5527	64433962
Disseminated varicella zoster virus infection	19.81	11.27	8	59235	270	64439219
Psoriasis	19.75	11.27	22	59221	71681	64367808
Cytomegalovirus test positive	19.73	11.27	24	59219	5120	64434369
Ureteral necrosis	19.66	11.27	6	59237	86	64439403
Parvovirus infection	19.63	11.27	10	59233	584	64438905
Colitis	19.62	11.27	106	59137	58568	64380921
Anorectal varices	19.60	11.27	5	59238	35	64439454
Mycobacterium abscessus infection	19.60	11.27	12	59231	1002	64438487
Central nervous system lupus	19.49	11.27	8	59235	282	64439207
Serotonin syndrome	19.33	11.27	6	59237	39276	64400213
Lower respiratory tract infection	19.20	11.27	36	59207	94578	64344911
Pneumonia klebsiella	19.13	11.27	21	59222	4016	64435473
Exposure during pregnancy	19.12	11.27	26	59217	77649	64361840
Nosocomial infection	19.12	11.27	17	59226	2520	64436969
Febrile neutropenia	19.08	11.27	98	59145	187559	64251930
Tuberculosis	19.03	11.27	39	59204	12999	64426490
Renal vein thrombosis	19.01	11.27	9	59234	448	64439041
Cytomegalovirus chorioretinitis	18.98	11.27	23	59220	4889	64434600
Histology abnormal	18.90	11.27	8	59235	305	64439184
Liver transplant	18.89	11.27	21	59222	4071	64435418
Propionibacterium infection	18.87	11.27	8	59235	306	64439183
Renal failure	18.80	11.27	252	58991	181436	64258053
Acid base balance abnormal	18.80	11.27	8	59235	309	64439180
Disseminated mycobacterium avium complex infection	18.77	11.27	6	59237	101	64439388
Bilirubin conjugated increased	18.77	11.27	23	59220	4945	64434544
Arthritis	18.73	11.27	30	59213	83784	64355705
Functional gastrointestinal disorder	18.73	11.27	21	59222	4110	64435379
Drug level decreased	18.70	11.27	36	59207	11467	64428022
Abdominal discomfort	18.65	11.27	95	59148	182227	64257262
Hepatitis C	18.56	11.27	35	59208	10980	64428509
Listeriosis	18.54	11.27	15	59228	1955	64437534
Fungaemia	18.47	11.27	20	59223	3765	64435724
Dermatitis papillaris capillitii	18.44	11.27	4	59239	12	64439477
Argentine haemorrhagic fever	18.44	11.27	4	59239	12	64439477
Transmission of an infectious agent via transplant	18.44	11.27	4	59239	12	64439477
Opportunistic infection	18.41	11.27	17	59226	2645	64436844
Vaccination failure	18.40	11.27	11	59232	880	64438609
Blood creatine phosphokinase increased	18.40	11.27	16	59227	58542	64380947
Anti-GAD antibody positive	18.40	11.27	5	59238	46	64439443
Bordetella infection	18.40	11.27	6	59237	108	64439381
Acute graft versus host disease in liver	18.37	11.27	14	59229	1673	64437816
Hallucination	18.28	11.27	24	59219	72764	64366725
Pyelonephritis fungal	18.19	11.27	6	59237	112	64439377
Polyomavirus test positive	18.17	11.27	7	59236	208	64439281
Organising pneumonia	18.11	11.27	31	59212	9024	64430465
IgA nephropathy	18.08	11.27	13	59230	1421	64438068
Transient ischaemic attack	18.04	11.27	9	59234	44173	64395316
Perinephric abscess	18.02	11.27	7	59236	213	64439276
Bronchiectasis	17.99	11.27	40	59203	14100	64425389
Vesicoureteral reflux surgery	17.98	11.27	3	59240	0	64439489
Gingival hypertrophy	17.96	11.27	17	59226	2730	64436759
Respiratory distress	17.81	11.27	95	59148	52236	64387253
Phaeohyphomycotic brain abscess	17.76	11.27	5	59238	53	64439436
Lymphorrhoea	17.71	11.27	6	59237	122	64439367
Serratia infection	17.46	11.27	13	59230	1500	64437989
Emphysematous pyelonephritis	17.46	11.27	7	59236	232	64439257
Acute pulmonary histoplasmosis	17.37	11.27	7	59236	235	64439254
Neurotoxicity	17.30	11.27	60	59183	27344	64412145
Transplantation complication	17.26	11.27	7	59236	239	64439250
Neoplasm progression	17.25	11.27	8	59235	40956	64398533
Dry mouth	17.24	11.27	18	59225	60400	64379089
Herpes simplex	17.16	11.27	33	59210	10503	64428986
Bacteraemia	17.06	11.27	59	59184	26852	64412637
Orthostatic hypotension	16.96	11.27	11	59232	46727	64392762
Haemoglobinaemia	16.86	11.27	7	59236	254	64439235
Drug withdrawal syndrome	16.86	11.27	4	59239	31287	64408202
Haemolytic anaemia	16.72	11.27	42	59201	16011	64423478
Delusion of grandeur	16.69	11.27	9	59234	591	64438898
Plasmapheresis	16.69	11.27	9	59234	591	64438898
Hot flush	16.62	11.27	11	59232	46224	64393265
Aggression	16.62	11.27	11	59232	46221	64393268
Rash pruritic	16.50	11.27	17	59226	57387	64382102
Mucinous adenocarcinoma of appendix	16.36	11.27	4	59239	23	64439466
Agranulocytosis	16.29	11.27	74	59169	38155	64401334
Pneumatosis intestinalis	16.29	11.27	22	59221	5207	64434282
Myopathy toxic	16.16	11.27	10	59233	851	64438638
Hepatic enzyme increased	16.13	11.27	63	59180	129880	64309609
Hyperammonaemia	16.11	11.27	31	59212	9873	64429616
Endocarditis	16.05	11.27	30	59213	9348	64430141
Peritonitis	15.98	11.27	55	59188	24968	64414521
Pneumonia fungal	15.95	11.27	29	59214	8848	64430641
Blood pressure increased	15.95	11.27	93	59150	172459	64267030
Agitation	15.92	11.27	36	59207	88331	64351158
Oral pain	15.87	11.27	3	59240	27490	64411999
Systemic bacterial infection	15.81	11.27	4	59239	27	64439462
Neck pain	15.75	11.27	20	59223	61513	64377976
Hypertriglyceridaemia	15.75	11.27	33	59210	11172	64428317
Incisional hernia	15.74	11.27	14	59229	2076	64437413
Platelet count decreased	15.71	11.27	90	59153	167621	64271868
Pancreatitis necrotising	15.70	11.27	17	59226	3200	64436289
Enterovirus infection	15.66	11.27	12	59231	1445	64438044
Neutropenia	15.66	11.27	308	58935	239316	64200173
Infective tenosynovitis	15.64	11.27	7	59236	306	64439183
Cytomegalovirus mucocutaneous ulcer	15.60	11.27	5	59238	85	64439404
B-cell lymphoma	15.56	11.27	22	59221	5435	64434054
Knee arthroplasty	15.47	11.27	3	59240	26996	64412493
Femur fracture	15.44	11.27	6	59237	34129	64405360
Normocytic anaemia	15.35	11.27	17	59226	3282	64436207
BK polyomavirus test positive	15.28	11.27	5	59238	91	64439398
Tuberculosis gastrointestinal	15.26	11.27	8	59235	496	64438993
Hemianopia heteronymous	15.23	11.27	5	59238	92	64439397
Lymphoproliferative disorder	15.18	11.27	21	59222	5082	64434407
Legionella infection	15.09	11.27	9	59234	717	64438772
Tularaemia	15.08	11.27	5	59238	95	64439394
Bacterial colitis	15.08	11.27	5	59238	95	64439394
Balamuthia infection	15.00	11.27	4	59239	34	64439455
Complications of transplant surgery	14.94	11.27	9	59234	730	64438759
Ejection fraction decreased	14.83	11.27	4	59239	28703	64410786
Pulmonary mass	14.66	11.27	52	59191	23964	64415525
Acinetobacter bacteraemia	14.57	11.27	6	59237	213	64439276
Memory impairment	14.56	11.27	36	59207	85646	64353843
Stenotrophomonas infection	14.55	11.27	16	59227	3064	64436425
Tuberculoma of central nervous system	14.55	11.27	8	59235	546	64438943
Cardiac murmur functional	14.51	11.27	4	59239	39	64439450
Swollen tongue	14.45	11.27	7	59236	34947	64404542
Secondary immunodeficiency	14.37	11.27	15	59228	2709	64436780
Swelling face	14.36	11.27	20	59223	59146	64380343
Fungal sepsis	14.30	11.27	12	59231	1646	64437843
Maternal exposure during pregnancy	14.26	11.27	43	59200	95841	64343648
Pallor	14.25	11.27	9	59234	38772	64400717
Scopulariopsis infection	14.23	11.27	5	59238	114	64439375
Angiocentric lymphoma	14.21	11.27	9	59234	798	64438691
Mediastinitis	14.19	11.27	9	59234	800	64438689
Hypoalbuminaemia	14.16	11.27	42	59201	17632	64421857
Azotaemia	14.11	11.27	25	59218	7477	64432012
Sebaceous carcinoma	14.10	11.27	5	59238	117	64439372
Cardiac failure	14.10	11.27	68	59175	132305	64307184
Endocarditis viral	14.09	11.27	3	59240	8	64439481
Folliculitis	14.08	11.27	5	59238	30072	64409417
Palpitations	14.05	11.27	49	59194	104439	64335050
Anaphylactic reaction	14.04	11.27	26	59217	68638	64370851
Oliguria	14.01	11.27	37	59206	14539	64424950
Sinus tachycardia	14.00	11.27	6	59237	32182	64407307
Helicobacter infection	13.96	11.27	9	59234	38353	64401136
Mycobacterium marinum infection	13.95	11.27	7	59236	396	64439093
Capillaritis	13.95	11.27	6	59237	238	64439251
Cerebrovascular accident	13.89	11.27	72	59171	137511	64301978
Full blood count abnormal	13.84	11.27	5	59238	29752	64409737
Conjunctival neoplasm	13.83	11.27	3	59240	9	64439480
Drug eruption	13.81	11.27	8	59235	36128	64403361
Venous stenosis	13.81	11.27	6	59237	244	64439245
Lip swelling	13.80	11.27	6	59237	31901	64407588
Feeling hot	13.72	11.27	13	59230	45650	64393839
Bacteroides bacteraemia	13.68	11.27	4	59239	49	64439440
Graft thrombosis	13.61	11.27	7	59236	417	64439072
Gastrointestinal mucosa hyperaemia	13.61	11.27	7	59236	417	64439072
Disseminated cytomegaloviral infection	13.60	11.27	7	59236	418	64439071
Abdominal wall haemorrhage	13.60	11.27	7	59236	418	64439071
Hepatic echinococciasis	13.59	11.27	3	59240	10	64439479
CD8 lymphocytes decreased	13.54	11.27	6	59237	256	64439233
Cytomegalovirus gastroenteritis	13.54	11.27	7	59236	422	64439067
Bile duct stenosis	13.53	11.27	12	59231	1772	64437717
Haemodynamic instability	13.47	11.27	37	59206	14875	64424614
Leiomyosarcoma	13.45	11.27	6	59237	260	64439229
Hyperamylasaemia	13.40	11.27	9	59234	882	64438607
Meningitis histoplasma	13.37	11.27	3	59240	11	64439478
Hypervolaemia	13.37	11.27	70	59173	38215	64401274
Graft complication	13.29	11.27	8	59235	648	64438841
Urinary tract candidiasis	13.24	11.27	8	59235	653	64438836
Blood albumin decreased	13.18	11.27	46	59197	21027	64418462
Upper gastrointestinal haemorrhage	13.18	11.27	8	59235	35212	64404277
Palmar-plantar erythrodysaesthesia syndrome	13.14	11.27	5	59238	28814	64410675
Herpes oesophagitis	13.14	11.27	6	59237	275	64439214
Mycoplasma infection	13.14	11.27	8	59235	662	64438827
Aspartate aminotransferase increased	13.07	11.27	61	59182	119727	64319762
Post procedural urine leak	13.06	11.27	5	59238	146	64439343
Medication error	13.04	11.27	16	59227	49950	64389539
Urine output decreased	13.04	11.27	39	59204	16453	64423036
Joint tuberculosis	13.03	11.27	5	59238	147	64439342
Large intestine infection	13.03	11.27	14	59229	2614	64436875
Accidental exposure to product	13.02	11.27	4	59239	26360	64413129
Klebsiella sepsis	13.01	11.27	14	59229	2618	64436871
Purulent pericarditis	13.00	11.27	4	59239	59	64439430
Cognitive disorder	13.00	11.27	19	59224	55068	64384421
Adenoviral hepatitis	12.96	11.27	7	59236	461	64439028
Genital herpes	12.91	11.27	12	59231	1883	64437606
Myeloma cast nephropathy	12.91	11.27	5	59238	151	64439338
Wound complication	12.89	11.27	17	59226	3931	64435558
Steroid diabetes	12.86	11.27	14	59229	2652	64436837
Pancreas transplant	12.82	11.27	4	59239	62	64439427
Glomerulosclerosis	12.75	11.27	9	59234	956	64438533
Dry skin	12.72	11.27	17	59226	51144	64388345
Pneumoperitoneum	12.67	11.27	14	59229	2697	64436792
Graft versus host disease in eye	12.67	11.27	6	59237	299	64439190
Hepatic cyst infection	12.66	11.27	5	59238	159	64439330
Small intestine gangrene	12.62	11.27	3	59240	15	64439474
Intra-abdominal haemorrhage	12.62	11.27	17	59226	4014	64435475
Orf	12.59	11.27	4	59239	66	64439423
Narrow anterior chamber angle	12.43	11.27	5	59238	167	64439322
Orbital apex syndrome	12.42	11.27	4	59239	69	64439420
Obstructive airways disorder	12.42	11.27	3	59240	23182	64416307
Encephalitis fungal	12.40	11.27	5	59238	168	64439321
Pemphigus	12.40	11.27	23	59220	60678	64378811
Splenorenal shunt	12.31	11.27	3	59240	17	64439472
Mesangioproliferative glomerulonephritis	12.26	11.27	4	59239	72	64439417
Brain compression	12.26	11.27	7	59236	514	64438975
Eczema	12.21	11.27	6	59237	29714	64409775
Rhinovirus infection	12.21	11.27	21	59222	6135	64433354
Abdominal wall abscess	12.17	11.27	9	59234	1027	64438462
Urinary tract infection viral	12.16	11.27	4	59239	74	64439415
Intestinal ulcer perforation	12.16	11.27	3	59240	18	64439471
Anorexia nervosa	12.13	11.27	5	59238	178	64439311
Rectal haemorrhage	12.12	11.27	24	59219	61793	64377696
Nephrotic syndrome	12.10	11.27	27	59216	9540	64429949
Hyperparathyroidism	12.09	11.27	14	59229	2838	64436651
Pneumonia adenoviral	12.08	11.27	5	59238	180	64439309
Pneumonia legionella	12.07	11.27	13	59230	2433	64437056
Influenza like illness	12.06	11.27	24	59219	61678	64377811
Carotid arteriosclerosis	11.97	11.27	12	59231	2067	64437422
Paracoccidioides infection	11.97	11.27	4	59239	78	64439411
Gene mutation	11.95	11.27	12	59231	2070	64437419
Granulomatous dermatitis	11.95	11.27	6	59237	340	64439149
Full blood count decreased	11.94	11.27	3	59240	22579	64416910
Thyroid gland abscess	11.92	11.27	4	59239	79	64439410
Alpha haemolytic streptococcal infection	11.90	11.27	11	59232	1714	64437775
Retinal artery occlusion	11.88	11.27	14	59229	2889	64436600
Sleep disorder	11.87	11.27	23	59220	59686	64379803
Burning sensation	11.84	11.27	17	59226	49647	64389842
Neutrophil Pelger-Huet anomaly present	11.83	11.27	6	59237	347	64439142
Vocal cord thickening	11.78	11.27	4	59239	82	64439407
Pulmonary alveolar haemorrhage	11.78	11.27	27	59216	9711	64429778
Leuconostoc infection	11.76	11.27	3	59240	21	64439468
Overdose	11.75	11.27	92	59151	159474	64280015
Arteritis infective	11.73	11.27	4	59239	83	64439406
Oropharyngeal pain	11.73	11.27	42	59201	88825	64350664
Intentional self-injury	11.73	11.27	6	59237	29038	64410451
Vision blurred	11.71	11.27	43	59200	90273	64349216
White blood cell count increased	11.70	11.27	102	59141	65912	64373577
Septic embolus	11.70	11.27	11	59232	1751	64437738
Vascular anastomotic haemorrhage	11.69	11.27	4	59239	84	64439405
Metastatic malignant melanoma	11.66	11.27	13	59230	2528	64436961
Glomerular filtration rate decreased	11.62	11.27	42	59201	19530	64419959
Encapsulating peritoneal sclerosis	11.61	11.27	8	59235	817	64438672
Toxicity to various agents	11.61	11.27	250	58993	363263	64076226
Perineal cyst	11.60	11.27	4	59239	86	64439403
Therapy change	11.54	11.27	21	59222	6413	64433076
Bronchitis	11.50	11.27	56	59187	108687	64330802
Escherichia bacteraemia	11.47	11.27	19	59224	5384	64434105
Mycobacterium fortuitum infection	11.42	11.27	5	59238	207	64439282
Viral skin infection	11.39	11.27	4	59239	91	64439398
Herpes zoster cutaneous disseminated	11.34	11.27	6	59237	379	64439110
Cutaneous tuberculosis	11.31	11.27	5	59238	212	64439277

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

Source	Code	Description
ATC	L04AA06	ANTINEOPLASTIC AND IMMUNOMODULATING AGENTS IMMUNOSUPPRESSANTS IMMUNOSUPPRESSANTS Selective immunosuppressants
MeSH PA	D000900	Anti-Bacterial Agents
MeSH PA	D000890	Anti-Infective Agents
MeSH PA	D000903	Antibiotics, Antineoplastic
MeSH PA	D000904	Antibiotics, Antitubercular
MeSH PA	D000970	Antineoplastic Agents
MeSH PA	D000995	Antitubercular Agents
MeSH PA	D004791	Enzyme Inhibitors
FDA EPC	N0000175613	Antimetabolite Immunosuppressant
CHEBI has role	CHEBI:35705	immunosuppressive agents
CHEBI has role	CHEBI:53746	EC 1.1.1.205 inhibitor
CHEBI has role	CHEBI:25442	mycotoxins
CHEBI has role	CHEBI:33281	antibiotics
CHEBI has role	CHEBI:35610	antineoplastic agents
CHEBI has role	CHEBI:35703	Xenobiotic
CHEBI has role	CHEBI:76964	Penicillium metabolites
CHEBI has role	CHEBI:78298	environmental contaminants
CHEBI has role	CHEBI:149553	anticoronaviral drug

Drug Use | Suggest Off label Use Form| |View source of the data|

Disease	Relation	SNOMED_ID	DOID
Prevention of Liver Transplant Rejection	indication
Prevention of Cardiac Transplant Rejection	indication
Prevention of Kidney Transplant Rejection	indication
Prevention of Lung Transplant Rejection	off-label use
Herpes zoster	contraindication	4740000	DOID:8536
Progressive multifocal leukoencephalopathy	contraindication	22255007	DOID:643
Cytomegalovirus infection	contraindication	28944009
Constitutional aplastic anemia	contraindication	28975000	DOID:1342
Gastrointestinal ulcer	contraindication	40845000
Gastrointestinal perforation	contraindication	51875005
Acute nephropathy	contraindication	58574008
Acute infectious disease	contraindication	63171007
Gastrointestinal hemorrhage	contraindication	74474003
Herpes simplex	contraindication	88594005	DOID:8566
Malignant lymphoma	contraindication	118600007	DOID:0060058
Deficiency of hypoxanthine phosphoribosyltransferase	contraindication	124275001
Disease of liver	contraindication	235856003	DOID:409
Pregnancy, function	contraindication	289908002
Neutropenic disorder	contraindication	303011007	DOID:1227
Bone marrow depression	contraindication	307762000
Primary malignant neoplasm	contraindication	372087000
Malignant neoplasm of skin	contraindication	372130007	DOID:4159
Breastfeeding (mother)	contraindication	413712001
Opportunistic Fungal Infection	contraindication
BK Polyomavirus Reactivation Nephropathy	contraindication

🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation level	Dissociation constant	Type (acidic/basic)
pKa1	4.67	acidic
pKa2	11.03	acidic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

Target	Class	Pharos	UniProt	Action	Type	Activity value (-log[M])	Bioact source	MoA source
Inosine-5'-monophosphate dehydrogenase (IMPDH)	Enzyme	P12268 P20839	IMDH2_HUMAN IMDH1_HUMAN	INHIBITOR	IC50	4.70	CHEMBL	CHEMBL
Inosine-5'-monophosphate dehydrogenase 1	Enzyme	P20839	IMDH1_HUMAN		Ki	7.48	CHEMBL
Inosine-5'-monophosphate dehydrogenase 2	Enzyme	P12268	IMDH2_HUMAN		Ki	8.22	CHEMBL
Inosine-5'-monophosphate dehydrogenase	Unclassified		IMDH_CRYNJ		IC50	6.92	CHEMBL

External reference:

ID	Source
4025608	VUID
N0000176078	NUI
D05095	KEGG_DRUG
4021418	VANDF
4025598	VANDF
4025608	VANDF
C0026933	UMLSCUI
CHEBI:168396	CHEBI
MOA	PDB_CHEM_ID
CHEMBL866	ChEMBL_ID
DB01024	DRUGBANK_ID
CHEMBL2106643	ChEMBL_ID
D009173	MESH_DESCRIPTOR_UI
446541	PUBCHEM_CID
6832	IUPHAR_LIGAND_ID
2950	INN_ID
HU9DX48N0T	UNII
265323	RXNORM
18132	MMSL
210716	MMSL
d05217	MMSL
005013	NDDF
009984	NDDF
409330005	SNOMEDCT_US
409331009	SNOMEDCT_US
426216009	SNOMEDCT_US
24280-93-1	SECONDARY_CAS_RN

Pharmaceutical products:

Product	Category	Ingredients	NDC	Form	Quantity	Route	Marketing	Label
Myfortic	HUMAN PRESCRIPTION DRUG LABEL	1	0078-0385	TABLET, DELAYED RELEASE	180 mg	ORAL	NDA	29 sections
Myfortic	HUMAN PRESCRIPTION DRUG LABEL	1	0078-0385	TABLET, DELAYED RELEASE	180 mg	ORAL	NDA	29 sections
Myfortic	HUMAN PRESCRIPTION DRUG LABEL	1	0078-0386	TABLET, DELAYED RELEASE	360 mg	ORAL	NDA	29 sections
Myfortic	HUMAN PRESCRIPTION DRUG LABEL	1	0078-0386	TABLET, DELAYED RELEASE	360 mg	ORAL	NDA	29 sections
Mycophenolic Acid	HUMAN PRESCRIPTION DRUG LABEL	1	0378-4201	TABLET, DELAYED RELEASE	180 mg	ORAL	ANDA	29 sections
Mycophenolic Acid	HUMAN PRESCRIPTION DRUG LABEL	1	0378-4202	TABLET, DELAYED RELEASE	360 mg	ORAL	ANDA	29 sections
Mycophenolic Acid	HUMAN PRESCRIPTION DRUG LABEL	1	0904-6785	TABLET, DELAYED RELEASE	180 mg	ORAL	ANDA	23 sections
Mycophenolic Acid	HUMAN PRESCRIPTION DRUG LABEL	1	0904-6785	TABLET, DELAYED RELEASE	180 mg	ORAL	ANDA	23 sections
Mycophenolic Acid	HUMAN PRESCRIPTION DRUG LABEL	1	0904-6786	TABLET, DELAYED RELEASE	360 mg	ORAL	ANDA	23 sections
Mycophenolic Acid	HUMAN PRESCRIPTION DRUG LABEL	1	0904-6786	TABLET, DELAYED RELEASE	360 mg	ORAL	ANDA	23 sections
Mycophenolic Acid	HUMAN PRESCRIPTION DRUG LABEL	1	16729-189	TABLET, DELAYED RELEASE	360 mg	ORAL	ANDA	27 sections
Mycophenolic Acid	HUMAN PRESCRIPTION DRUG LABEL	1	16729-261	TABLET, DELAYED RELEASE	180 mg	ORAL	ANDA	27 sections
mycophenolic acid	HUMAN PRESCRIPTION DRUG LABEL	1	24979-160	TABLET, DELAYED RELEASE	180 mg	ORAL	ANDA	29 sections
mycophenolic acid	HUMAN PRESCRIPTION DRUG LABEL	1	24979-161	TABLET, DELAYED RELEASE	360 mg	ORAL	ANDA	29 sections
Mycophenolic Acid	HUMAN PRESCRIPTION DRUG LABEL	1	50268-559	TABLET, DELAYED RELEASE	180 mg	ORAL	ANDA	23 sections
Mycophenolic Acid	HUMAN PRESCRIPTION DRUG LABEL	1	50268-560	TABLET, DELAYED RELEASE	360 mg	ORAL	ANDA	23 sections
Mycophenolic Acid	HUMAN PRESCRIPTION DRUG LABEL	1	51079-508	TABLET, DELAYED RELEASE	180 mg	ORAL	ANDA	29 sections
Mycophenolic Acid	HUMAN PRESCRIPTION DRUG LABEL	1	51079-509	TABLET, DELAYED RELEASE	360 mg	ORAL	ANDA	29 sections
Mycophenolic Acid	HUMAN PRESCRIPTION DRUG LABEL	1	60429-016	TABLET, DELAYED RELEASE	180 mg	ORAL	ANDA	23 sections
Mycophenolic Acid	HUMAN PRESCRIPTION DRUG LABEL	1	60429-017	TABLET, DELAYED RELEASE	360 mg	ORAL	ANDA	23 sections
Mycophenolic Acid	HUMAN PRESCRIPTION DRUG LABEL	1	60505-2965	TABLET, DELAYED RELEASE	180 mg	ORAL	ANDA	23 sections
Mycophenolic Acid	HUMAN PRESCRIPTION DRUG LABEL	1	60505-2965	TABLET, DELAYED RELEASE	180 mg	ORAL	ANDA	23 sections
Mycophenolic Acid	HUMAN PRESCRIPTION DRUG LABEL	1	60505-2966	TABLET, DELAYED RELEASE	360 mg	ORAL	ANDA	23 sections
Mycophenolic Acid	HUMAN PRESCRIPTION DRUG LABEL	1	60505-2966	TABLET, DELAYED RELEASE	360 mg	ORAL	ANDA	23 sections
MYCOPHENOLIC ACID	Human Prescription Drug Label	1	67877-426	TABLET, DELAYED RELEASE	180 mg	ORAL	ANDA	28 sections
MYCOPHENOLIC ACID	Human Prescription Drug Label	1	67877-427	TABLET, DELAYED RELEASE	360 mg	ORAL	ANDA	28 sections
Mycophenolic Acid	HUMAN PRESCRIPTION DRUG LABEL	1	68084-907	TABLET, DELAYED RELEASE	180 mg	ORAL	ANDA	26 sections
Mycophenolic Acid	HUMAN PRESCRIPTION DRUG LABEL	1	68084-918	TABLET, DELAYED RELEASE	360 mg	ORAL	ANDA	26 sections
mycophenolic acid	HUMAN PRESCRIPTION DRUG LABEL	1	68254-5001	TABLET, DELAYED RELEASE	180 mg	ORAL	ANDA	26 sections
mycophenolic acid	HUMAN PRESCRIPTION DRUG LABEL	1	68254-5002	TABLET, DELAYED RELEASE	360 mg	ORAL	ANDA	26 sections