mycophenolic acid ๐Ÿถ Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
1860 37415-62-6

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • mycophenolate
  • mycophenolic acid
  • mycophenolate sodium
  • mycophenolic acid monosodium salt
  • sodium mycophenolate
Compound derived from Penicillium stoloniferum and related species. It blocks de novo biosynthesis of purine nucleotides by inhibition of the enzyme inosine monophosphate dehydrogenase (IMP DEHYDROGENASE). Mycophenolic acid exerts selective effects on the immune system in which it prevents the proliferation of T-CELLS, LYMPHOCYTES, and the formation of antibodies from B-CELLS. It may also inhibit recruitment of LEUKOCYTES to sites of INFLAMMATION.
  • Molecular weight: 320.34
  • Formula: C17H20O6
  • CLOGP: 2.29
  • LIPINSKI: 0
  • HAC: 6
  • HDO: 2
  • TPSA: 93.06
  • ALOGS: -3.96
  • ROTB: 6

  • Status: OFP

  • Legend:
    OFP - off patent
    OFM - off market
    ONP - on patent

Drug dosage:

DoseUnitRoute
2 g O
2 g P

ADMET properties:

PropertyValueReference
BDDCS (Biopharmaceutical Drug Disposition Classification System) 2 Benet LZ, Broccatelli F, Oprea TI
EoM (Fraction excreted unchanged in urine) 0.50 % Benet LZ, Broccatelli F, Oprea TI
MRTD (Maximum Recommended Therapeutic Daily Dose) 64.22 ยตM/kg/day Contrera JF, Matthews EJ, Kruhlak NL, Benz RD
Vd (Volume of distribution) 0.77 L/kg Lombardo F, Berellini G, Obach RS
CL (Clearance) 2.33 mL/min/kg Lombardo F, Berellini G, Obach RS
fu (Fraction unbound in plasma) 0.02 % Lombardo F, Berellini G, Obach RS
t_half (Half-life) 9.70 hours Lombardo F, Berellini G, Obach RS

Approvals:

DateAgencyCompanyOrphan
Feb. 27, 2004 FDA NOVARTIS

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Cytomegalovirus infection 731.77 12.08 305 29551 17657 50557611
Transplant rejection 518.96 12.08 200 29656 9409 50565859
Kidney transplant rejection 426.58 12.08 138 29718 3849 50571419
Post transplant lymphoproliferative disorder 344.33 12.08 119 29737 4085 50571183
Complications of transplanted kidney 306.85 12.08 93 29763 2080 50573188
Polyomavirus-associated nephropathy 234.56 12.08 70 29786 1482 50573786
Thrombotic microangiopathy 222.22 12.08 107 29749 8684 50566584
Cytomegalovirus viraemia 198.45 12.08 82 29774 4627 50570641
BK virus infection 192.04 12.08 70 29786 2811 50572457
Product use in unapproved indication 188.27 12.08 283 29573 115536 50459732
COVID-19 185.91 12.08 180 29676 46482 50528786
Epstein-Barr virus infection 182.43 12.08 87 29769 6910 50568358
Posterior reversible encephalopathy syndrome 176.72 12.08 110 29746 14818 50560450
Immunosuppressant drug level increased 165.79 12.08 64 29792 3018 50572250
Off label use 163.91 12.08 631 29225 473795 50101473
Delayed graft function 158.31 12.08 46 29810 884 50574384
Leukopenia 156.53 12.08 196 29660 67332 50507936
Kidney fibrosis 141.89 12.08 48 29808 1541 50573727
Pneumocystis jirovecii pneumonia 139.02 12.08 94 29762 14569 50560699
Chronic allograft nephropathy 126.94 12.08 36 29820 632 50574636
Parvovirus B19 infection 123.85 12.08 33 29823 454 50574814
Blood creatinine increased 112.27 12.08 178 29678 75982 50499286
Renal impairment 110.38 12.08 176 29680 75485 50499783
Nephropathy toxic 107.42 12.08 64 29792 7965 50567303
Graft versus host disease in skin 99.27 12.08 42 29814 2514 50572754
Trichodysplasia spinulosa 95.15 12.08 27 29829 475 50574793
Graft versus host disease in gastrointestinal tract 92.62 12.08 41 29815 2740 50572528
Histoplasmosis disseminated 92.27 12.08 33 29823 1253 50574015
Multiple organ dysfunction syndrome 91.81 12.08 130 29726 50207 50525061
Escherichia infection 89.33 12.08 64 29792 10877 50564391
Tubulointerstitial nephritis 89.06 12.08 73 29783 15138 50560130
West Nile viral infection 88.46 12.08 24 29832 355 50574913
Cryptococcosis 87.94 12.08 29 29827 859 50574409
Aspergillus infection 87.70 12.08 53 29803 6768 50568500
Renal transplant failure 85.53 12.08 26 29830 587 50574681
Varicella zoster virus infection 83.88 12.08 37 29819 2452 50572816
Lymphocele 83.01 12.08 27 29829 765 50574503
Human herpesvirus 6 infection 82.25 12.08 37 29819 2569 50572699
Epstein-Barr viraemia 80.34 12.08 27 29829 849 50574419
Acute kidney injury 78.82 12.08 304 29552 227754 50347514
Transplant dysfunction 77.81 12.08 43 29813 4641 50570627
Respiratory failure 73.93 12.08 165 29691 91016 50484252
Arthropathy 70.83 12.08 6 29850 157900 50417368
Fatigue 70.35 12.08 201 29655 707400 49867868
Apoptosis 69.38 12.08 15 29841 77 50575191
Pain 67.09 12.08 152 29704 578751 49996517
Graft loss 66.76 12.08 19 29837 338 50574930
Adenovirus infection 66.52 12.08 34 29822 3134 50572134
Liver transplant rejection 66.19 12.08 26 29830 1284 50573984
Polyomavirus viraemia 61.76 12.08 19 29837 447 50574821
Histoplasmosis 58.80 12.08 26 29830 1733 50573535
Post transplant distal limb syndrome 58.41 12.08 15 29841 177 50575091
Aplasia pure red cell 57.43 12.08 34 29822 4181 50571087
Cytomegalovirus colitis 56.52 12.08 26 29830 1901 50573367
Diffuse large B-cell lymphoma 55.34 12.08 37 29819 5625 50569643
Focal segmental glomerulosclerosis 55.30 12.08 23 29833 1318 50573950
JC virus infection 54.84 12.08 25 29831 1790 50573478
Bronchopulmonary aspergillosis 54.28 12.08 41 29815 7551 50567717
Klebsiella infection 54.00 12.08 40 29816 7154 50568114
Renal tubular atrophy 53.68 12.08 18 29838 562 50574706
Drug hypersensitivity 53.35 12.08 42 29814 250968 50324300
Disseminated cryptococcosis 52.10 12.08 16 29840 374 50574894
Human polyomavirus infection 52.08 12.08 15 29841 279 50574989
Ureaplasma infection 51.63 12.08 17 29839 501 50574767
Human ehrlichiosis 50.50 12.08 13 29843 155 50575113
Blastomycosis 49.95 12.08 14 29842 235 50575033
Haemophagocytic lymphohistiocytosis 49.63 12.08 41 29815 8592 50566676
Rash 48.87 12.08 117 29739 437354 50137914
Pancreas transplant rejection 48.00 12.08 12 29844 126 50575142
Drug level increased 47.93 12.08 58 29798 19210 50556058
Arthralgia 46.91 12.08 120 29736 438582 50136686
Graft versus host disease 45.64 12.08 34 29822 6132 50569136
Fall 45.50 12.08 80 29776 334852 50240416
Central nervous system lymphoma 45.06 12.08 20 29836 1345 50573923
Contraindicated product administered 44.71 12.08 16 29840 148942 50426326
Diabetes mellitus 43.44 12.08 92 29764 48941 50526327
Viraemia 42.86 12.08 18 29838 1057 50574211
Angiosarcoma 42.19 12.08 12 29844 213 50575055
Renal tubular necrosis 41.91 12.08 40 29816 10128 50565140
Phaeohyphomycosis 41.57 12.08 12 29844 225 50575043
Injection site pain 40.74 12.08 8 29848 111016 50464252
Renal transplant 40.68 12.08 18 29838 1201 50574067
Proteinuria 39.72 12.08 49 29807 16548 50558720
Immunosuppressant drug level decreased 39.46 12.08 16 29840 859 50574409
Encephalitis viral 39.02 12.08 19 29837 1578 50573690
Joint swelling 38.62 12.08 53 29803 245233 50330035
Toxoplasmosis 38.09 12.08 18 29838 1399 50573869
Nocardiosis 37.92 12.08 19 29837 1679 50573589
Haemolytic uraemic syndrome 37.73 12.08 21 29835 2298 50572970
Disseminated mucormycosis 37.30 12.08 10 29846 141 50575127
Biopsy lung abnormal 37.23 12.08 10 29846 142 50575126
Hypersensitivity 36.44 12.08 44 29812 215117 50360151
Diarrhoea 36.13 12.08 516 29340 587960 49987308
Atypical haemolytic uraemic syndrome 35.14 12.08 13 29843 544 50574724
Renal failure 35.00 12.08 140 29716 106493 50468775
Acute graft versus host disease 34.26 12.08 24 29832 3934 50571334
Interstitial lung disease 34.19 12.08 88 29768 53088 50522180
Enterococcal infection 34.01 12.08 30 29826 6868 50568400
Alveolar proteinosis 33.91 12.08 11 29845 309 50574959
Synovitis 32.83 12.08 16 29840 123849 50451419
Infusion related reaction 32.80 12.08 31 29825 169526 50405742
Wound 32.37 12.08 11 29845 105783 50469485
Acute respiratory distress syndrome 32.00 12.08 50 29806 21049 50554219
Gastroenteritis norovirus 31.69 12.08 17 29839 1730 50573538
Pyrexia 31.65 12.08 353 29503 379850 50195418
Rhodococcus infection 31.42 12.08 8 29848 91 50575177
Dizziness 30.96 12.08 103 29753 346266 50229002
Hypogammaglobulinaemia 30.55 12.08 26 29830 5673 50569595
Escherichia urinary tract infection 30.38 12.08 34 29822 10361 50564907
Pruritus 29.91 12.08 78 29778 283490 50291778
Protein urine present 29.79 12.08 25 29831 5352 50569916
Rheumatoid arthritis 29.68 12.08 46 29810 202504 50372764
Malacoplakia vesicae 29.60 12.08 7 29849 57 50575211
Pseudomonas infection 29.56 12.08 32 29824 9398 50565870
Biloma 29.28 12.08 7 29849 60 50575208
Malacoplakia gastrointestinal 29.07 12.08 7 29849 62 50575206
Swelling 29.07 12.08 46 29810 200826 50374442
Hospitalisation 28.86 12.08 97 29759 67840 50507428
Cystitis haemorrhagic 28.72 12.08 21 29835 3681 50571587
Discomfort 28.72 12.08 14 29842 108366 50466902
Urinary tract infection 28.65 12.08 228 29628 223792 50351476
Stomatitis 28.56 12.08 12 29844 101332 50473936
Brain abscess 28.54 12.08 16 29840 1775 50573493
Vaccination failure 28.41 12.08 10 29846 362 50574906
Microsporidia infection 28.37 12.08 9 29847 235 50575033
Injection site erythema 28.34 12.08 5 29851 74931 50500337
Mycobacterium avium complex infection 28.31 12.08 18 29838 2512 50572756
Haemolytic anaemia 28.20 12.08 31 29825 9261 50566007
Renal tubular injury 27.83 12.08 10 29846 385 50574883
Progressive multifocal leukoencephalopathy 27.70 12.08 34 29822 11423 50563845
Human herpesvirus 6 encephalitis 27.66 12.08 8 29848 151 50575117
Disseminated mycobacterium avium complex infection 27.25 12.08 6 29850 34 50575234
Philadelphia positive chronic myeloid leukaemia 27.11 12.08 6 29850 35 50575233
Acute graft versus host disease in intestine 27.10 12.08 15 29841 1624 50573644
Malignant neoplasm progression 26.98 12.08 4 29852 68120 50507148
Lupus nephritis 26.97 12.08 17 29839 2338 50572930
End stage renal disease 26.40 12.08 24 29832 5713 50569555
Insomnia 26.30 12.08 39 29817 174826 50400442
Pyelonephritis 26.26 12.08 38 29818 14951 50560317
Cytomegalovirus hepatitis 26.05 12.08 9 29847 308 50574960
Bacterial pyelonephritis 25.75 12.08 9 29847 319 50574949
Pemphigus 25.63 12.08 20 29836 120146 50455122
Graft complication 25.47 12.08 8 29848 202 50575066
Anxiety 25.38 12.08 41 29815 177565 50397703
Obliterative bronchiolitis 25.38 12.08 15 29841 1838 50573430
Hepatitis E 25.25 12.08 13 29843 1216 50574052
Lymphopenia 25.06 12.08 38 29818 15583 50559685
Disseminated varicella zoster vaccine virus infection 25.04 12.08 6 29850 52 50575216
Chromoblastomycosis 25.01 12.08 5 29851 16 50575252
Infection reactivation 24.89 12.08 12 29844 975 50574293
Contusion 24.79 12.08 18 29838 112165 50463103
Cytomegalovirus nephritis 24.78 12.08 5 29851 17 50575251
Depression 24.77 12.08 37 29819 165386 50409882
Herpes simplex oesophagitis 24.67 12.08 7 29849 123 50575145
Incision site pain 24.62 12.08 12 29844 999 50574269
Diabetic macroangiopathy 24.57 12.08 7 29849 125 50575143
Hyperammonaemia 24.20 12.08 21 29835 4703 50570565
Intentional overdose 24.01 12.08 4 29852 62500 50512768
Escherichia pyelonephritis 24.01 12.08 9 29847 391 50574877
Urinary fistula 23.95 12.08 5 29851 21 50575247
Alopecia 23.90 12.08 70 29786 244977 50330291
Anogenital warts 23.83 12.08 9 29847 399 50574869
Septic shock 23.73 12.08 81 29775 57094 50518174
Nasopharyngitis 23.60 12.08 49 29807 192878 50382390
Agranulocytosis 23.54 12.08 44 29812 21377 50553891
Coccidioidomycosis 23.33 12.08 11 29845 851 50574417
Psoriasis 23.24 12.08 6 29850 68994 50506274
Liver abscess 23.09 12.08 16 29840 2577 50572691
Osteoarthritis 23.04 12.08 6 29850 68600 50506668
Heart transplant rejection 22.90 12.08 9 29847 445 50574823
Perinephric abscess 22.78 12.08 7 29849 164 50575104
Cytomegalovirus chorioretinitis 22.76 12.08 13 29843 1494 50573774
Drug interaction 22.74 12.08 198 29658 199423 50375845
Cat scratch disease 22.74 12.08 7 29849 165 50575103
Blister 22.68 12.08 11 29845 85407 50489861
Pancytopenia 22.68 12.08 104 29752 83926 50491342
Pyelonephritis acute 22.65 12.08 19 29837 4064 50571204
Enterobacter infection 22.55 12.08 14 29842 1874 50573394
Polyomavirus test positive 22.55 12.08 6 29850 82 50575186
Suicidal ideation 22.53 12.08 3 29853 55382 50519886
Central nervous system lupus 22.39 12.08 8 29848 303 50574965
Cerebral toxoplasmosis 22.30 12.08 10 29846 689 50574579
Cytomegalovirus syndrome 22.22 12.08 6 29850 87 50575181
Balance disorder 22.18 12.08 7 29849 70583 50504685
Necrotising herpetic retinopathy 22.16 12.08 6 29850 88 50575180
Disseminated cytomegaloviral infection 22.13 12.08 7 29849 181 50575087
Mycobacterial infection 22.07 12.08 13 29843 1583 50573685
Systemic candida 22.04 12.08 16 29840 2774 50572494
Abdominal discomfort 21.99 12.08 67 29789 231574 50343694
Lung transplant 21.86 12.08 16 29840 2809 50572459
Urinary tract candidiasis 21.85 12.08 9 29847 503 50574765
Herpes simplex hepatitis 21.85 12.08 8 29848 325 50574943
Papilloma viral infection 21.71 12.08 12 29844 1295 50573973
Hydronephrosis 21.71 12.08 26 29830 8515 50566753
Urinoma 21.68 12.08 5 29851 36 50575232
Sepsis 21.40 12.08 143 29713 132782 50442486
Lung transplant rejection 21.38 12.08 10 29846 759 50574509
Mucormycosis 21.36 12.08 15 29841 2468 50572800
Neutropenia 21.36 12.08 155 29701 147810 50427458
Oesophageal candidiasis 21.25 12.08 20 29836 4974 50570294
Pneumopericardium 21.22 12.08 5 29851 40 50575228
Pyelonephritis fungal 21.07 12.08 6 29850 107 50575161
Complications of transplanted lung 20.89 12.08 7 29849 218 50575050
Rhinovirus infection 20.76 12.08 17 29839 3517 50571751
Human herpesvirus 8 infection 20.71 12.08 7 29849 224 50575044
Transplant failure 20.68 12.08 12 29844 1421 50573847
Candida infection 20.66 12.08 44 29812 23479 50551789
Pain in extremity 20.54 12.08 87 29769 272778 50302490
Acid base balance abnormal 20.25 12.08 7 29849 240 50575028
Dermatitis papillaris capillitii 20.21 12.08 4 29852 12 50575256
Systemic bacterial infection 20.21 12.08 4 29852 12 50575256
Drug level decreased 20.18 12.08 22 29834 6511 50568757
Ureteral necrosis 20.13 12.08 5 29851 51 50575217
Donor specific antibody present 20.10 12.08 6 29850 127 50575141
Nosocomial infection 20.01 12.08 12 29844 1510 50573758
Chronic kidney disease 19.82 12.08 60 29796 39711 50535557
Therapeutic product effect decreased 19.82 12.08 31 29825 136019 50439249
Mucinous adenocarcinoma of appendix 19.74 12.08 4 29852 14 50575254
Pneumonia cytomegaloviral 19.73 12.08 13 29843 1928 50573340
Encephalitis 19.64 12.08 23 29833 7357 50567911
Pericarditis 19.61 12.08 11 29845 78678 50496590
Plasmapheresis 19.59 12.08 7 29849 265 50575003
Mycobacterium chelonae infection 19.56 12.08 8 29848 439 50574829
Helicobacter infection 19.50 12.08 3 29853 49699 50525569
Forced vital capacity decreased 19.47 12.08 10 29846 931 50574337
Back pain 19.24 12.08 66 29790 219964 50355304
Concomitant disease progression 19.11 12.08 13 29843 2032 50573236
Renal lymphocele 19.02 12.08 5 29851 65 50575203
American trypanosomiasis 18.95 12.08 5 29851 66 50575202
Epstein-Barr virus associated lymphoproliferative disorder 18.86 12.08 12 29844 1677 50573591
Pulmonary alveolar haemorrhage 18.83 12.08 17 29839 4010 50571258
Bacillary angiomatosis 18.55 12.08 5 29851 72 50575196
Hypoaesthesia 18.53 12.08 29 29827 127228 50448040
Emphysematous pyelonephritis 18.38 12.08 6 29850 172 50575096
Smooth muscle cell neoplasm 18.32 12.08 9 29847 762 50574506
Irritable bowel syndrome 18.26 12.08 4 29852 51437 50523831
Constipation 18.13 12.08 53 29803 185655 50389613
Encephalitis cytomegalovirus 18.08 12.08 8 29848 534 50574734
Wheezing 18.04 12.08 7 29849 62040 50513228
Tuberculosis gastrointestinal 17.99 12.08 7 29849 337 50574931
Neutrophil count increased 17.96 12.08 31 29825 14164 50561104
Hypertriglyceridaemia 17.86 12.08 19 29837 5472 50569796
Bacteroides bacteraemia 17.84 12.08 4 29852 25 50575243
Glomerulosclerosis 17.79 12.08 7 29849 347 50574921
Hyperamylasaemia 17.76 12.08 7 29849 349 50574919
Acute motor axonal neuropathy 17.70 12.08 4 29852 26 50575242
Fanconi syndrome 17.70 12.08 10 29846 1126 50574142
Red blood cells urine positive 17.69 12.08 14 29842 2761 50572507
Meningitis cryptococcal 17.63 12.08 10 29846 1135 50574133
Bacteraemia 17.58 12.08 31 29825 14402 50560866
Confusional state 17.48 12.08 54 29802 185874 50389394
New onset diabetes after transplantation 17.41 12.08 5 29851 92 50575176
Strongyloidiasis 17.40 12.08 9 29847 850 50574418
Urosepsis 17.29 12.08 32 29824 15433 50559835
COVID-19 pneumonia 17.28 12.08 23 29833 8372 50566896
Oesophageal ulcer 17.18 12.08 16 29840 3929 50571339
Sinusitis 17.14 12.08 48 29808 170510 50404758
Brain natriuretic peptide increased 17.14 12.08 17 29839 4510 50570758
Fibromyalgia 17.01 12.08 3 29853 44975 50530293
Disease recurrence 16.99 12.08 37 29819 20044 50555224
Gastrointestinal mucormycosis 16.85 12.08 6 29850 225 50575043
Nephropathy 16.76 12.08 18 29838 5240 50570028
Hepatic enzyme increased 16.70 12.08 35 29821 137345 50437923
Malacoplakia 16.61 12.08 5 29851 109 50575159
Disseminated tuberculosis 16.56 12.08 13 29843 2533 50572735
Acanthamoeba infection 16.56 12.08 4 29852 36 50575232
Scedosporium infection 16.45 12.08 7 29849 425 50574843
Joint tuberculosis 16.40 12.08 5 29851 114 50575154
Nephrotic syndrome 16.39 12.08 17 29839 4753 50570515
Purulent pericarditis 16.36 12.08 4 29852 38 50575230
Skin hypertrophy 16.35 12.08 14 29842 3081 50572187
Biopsy kidney 16.20 12.08 5 29851 119 50575149
Cardiac murmur functional 16.18 12.08 4 29852 40 50575228
Pneumonia 16.15 12.08 313 29543 378088 50197180
Neuropathy peripheral 16.13 12.08 20 29836 96737 50478531
Drug resistance 16.08 12.08 35 29821 18954 50556314
Pancreatitis necrotising 16.08 12.08 10 29846 1343 50573925
Orbital apex syndrome 16 12.08 4 29852 42 50575226
Epstein-Barr virus associated lymphoma 15.89 12.08 7 29849 462 50574806
Influenza like illness 15.87 12.08 7 29849 57452 50517816
Acute pulmonary histoplasmosis 15.56 12.08 5 29851 136 50575132
Graft versus host disease in liver 15.54 12.08 7 29849 487 50574781
Colitis 15.47 12.08 54 29802 38475 50536793
Cytomegalovirus gastrointestinal infection 15.44 12.08 6 29850 288 50574980
Necrotising retinitis 15.26 12.08 6 29850 297 50574971
Meningitis histoplasma 15.16 12.08 3 29853 9 50575259
Renal disorder 15.14 12.08 43 29813 27462 50547806
Mycobacterium abscessus infection 15.06 12.08 7 29849 524 50574744
Mobility decreased 15 12.08 15 29841 79933 50495335
Urticaria 14.92 12.08 34 29822 129527 50445741
Renal necrosis 14.82 12.08 4 29852 58 50575210
B-cell lymphoma 14.75 12.08 13 29843 2972 50572296
Therapy cessation 14.65 12.08 41 29815 25970 50549298
Cardiac failure congestive 14.54 12.08 17 29839 84365 50490903
Graft versus host disease in eye 14.45 12.08 4 29852 64 50575204
Mucocutaneous leishmaniasis 14.41 12.08 6 29850 345 50574923
Hepatic echinococciasis 14.29 12.08 3 29853 13 50575255
Graft versus host disease in lung 14.29 12.08 6 29850 352 50574916
Bacterial colitis 14.17 12.08 4 29852 69 50575199
Lung diffusion test decreased 14.15 12.08 7 29849 602 50574666
Pneumonia fungal 14.14 12.08 15 29841 4305 50570963
Cytomegalovirus infection reactivation 14.10 12.08 12 29844 2619 50572649
Anorexia nervosa 14.05 12.08 5 29851 187 50575081
Leiomyosarcoma 14 12.08 5 29851 189 50575079
Pathogen resistance 13.94 12.08 17 29839 5672 50569596
Herpes simplex 13.79 12.08 19 29837 7143 50568125
Normocytic anaemia 13.76 12.08 9 29847 1318 50573950
Bronchiectasis 13.72 12.08 23 29833 10260 50565008
Transplant 13.72 12.08 7 29849 643 50574625
Anaemia 13.69 12.08 217 29639 252239 50323029
Gastroenteritis cryptosporidial 13.66 12.08 4 29852 79 50575189
Mycoplasma infection 13.62 12.08 6 29850 396 50574872
Product monitoring error 13.58 12.08 12 29844 2752 50572516
Anuria 13.50 12.08 24 29832 11220 50564048
Histoplasmosis cutaneous 13.34 12.08 3 29853 19 50575249
Pulmonary function test decreased 13.34 12.08 13 29843 3375 50571893
Immunosuppression 13.26 12.08 19 29837 7407 50567861
Pulmonary mucormycosis 13.26 12.08 5 29851 221 50575047
Oesophageal stenosis 13.24 12.08 12 29844 2846 50572422
Myocardial infarction 13.23 12.08 20 29836 89007 50486261
Aphthous ulcer 13.22 12.08 23 29833 10574 50564694
Nephrostomy 13.21 12.08 4 29852 89 50575179
Chronic graft versus host disease 13.21 12.08 12 29844 2855 50572413
Lymphoproliferative disorder 13.17 12.08 12 29844 2865 50572403
Hyperuricaemia 13.15 12.08 15 29841 4665 50570603
Intentional product use issue 13.13 12.08 84 29772 76834 50498434
Gait disturbance 13.10 12.08 45 29811 149960 50425308
Extremity necrosis 12.92 12.08 9 29847 1462 50573806
Organising pneumonia 12.91 12.08 15 29841 4759 50570509
Urinary tract infection bacterial 12.84 12.08 14 29842 4145 50571123
Injection site bruising 12.76 12.08 3 29853 36765 50538503
Bone marrow granuloma 12.73 12.08 3 29853 24 50575244
Sterile pyuria 12.73 12.08 3 29853 24 50575244
Neuroendocrine carcinoma of the skin 12.70 12.08 6 29850 466 50574802
Squamous cell carcinoma 12.66 12.08 19 29837 7720 50567548
Hepatic cyst infection 12.66 12.08 4 29852 103 50575165
Bacterial sepsis 12.64 12.08 13 29843 3599 50571669
Asthenia 12.54 12.08 124 29732 318918 50256350
Fungaemia 12.50 12.08 10 29846 2002 50573266
Weight increased 12.48 12.08 69 29787 201822 50373446
Eye infection viral 12.48 12.08 4 29852 108 50575160
Fungal sepsis 12.39 12.08 8 29848 1146 50574122
Cystitis viral 12.38 12.08 4 29852 111 50575157
Dry skin 12.35 12.08 5 29851 43186 50532082
Poikilocytosis 12.31 12.08 4 29852 113 50575155
Renal haemorrhage 12.26 12.08 7 29849 804 50574464
Genital herpes 12.20 12.08 9 29847 1598 50573670
Superinfection bacterial 12.20 12.08 6 29850 509 50574759
Necrotising fasciitis 12.19 12.08 11 29845 2593 50572675
Wrong technique in product usage process 12.13 12.08 9 29847 55501 50519767
Pneumonia haemophilus 12.08 12.08 6 29850 520 50574748

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Kidney transplant rejection 673.95 12.56 271 35989 6734 29531533
Cytomegalovirus infection 575.86 12.56 357 35903 22858 29515409
Transplant rejection 511.67 12.56 242 36018 8970 29529297
Complications of transplanted kidney 429.30 12.56 167 36093 3787 29534480
COVID-19 395.29 12.56 338 35922 35676 29502591
Polyomavirus-associated nephropathy 308.01 12.56 126 36134 3270 29534997
Post transplant lymphoproliferative disorder 252.92 12.56 127 36133 5366 29532901
Immunosuppressant drug level increased 251.74 12.56 121 36139 4644 29533623
BK virus infection 250.11 12.56 120 36140 4587 29533680
Transplant dysfunction 222.28 12.56 89 36171 2181 29536086
Hepatitis E 207.87 12.56 78 36182 1596 29536671
Renal transplant failure 199.46 12.56 66 36194 917 29537350
Thrombotic microangiopathy 193.75 12.56 125 36135 8556 29529711
Blood creatinine increased 191.09 12.56 360 35900 84742 29453525
Cytomegalovirus viraemia 163.63 12.56 100 36160 6220 29532047
Leukopenia 158.12 12.56 260 36000 54943 29483324
West Nile viral infection 149.54 12.56 48 36212 602 29537665
Delayed graft function 146.27 12.56 63 36197 1864 29536403
JC virus infection 140.65 12.56 61 36199 1836 29536431
Aspergillus infection 140.39 12.56 111 36149 10470 29527797
Product use in unapproved indication 138.06 12.56 319 35941 86556 29451711
Parvovirus B19 infection 136.52 12.56 46 36214 678 29537589
Transplant failure 122.62 12.56 63 36197 2793 29535474
Nephropathy toxic 122.01 12.56 103 36157 10653 29527614
Incision site pain 115.02 12.56 52 36208 1731 29536536
Epstein-Barr virus infection 108.86 12.56 79 36181 6550 29531717
Cryptococcosis 107.44 12.56 51 36209 1901 29536366
Mucormycosis 107.08 12.56 71 36189 5087 29533180
Drug level increased 106.22 12.56 123 36137 18664 29519603
Renal tubular atrophy 102.55 12.56 41 36219 1000 29537267
Nocardiosis 101.18 12.56 58 36202 3202 29535065
Kidney fibrosis 99.15 12.56 49 36211 1998 29536269
Bronchopulmonary aspergillosis 96.57 12.56 96 36164 12248 29526019
Phaeohyphomycosis 94.70 12.56 36 36224 764 29537503
Pseudomonas infection 91.63 12.56 88 36172 10764 29527503
COVID-19 pneumonia 91.54 12.56 83 36177 9439 29528828
Fall 91.26 12.56 52 36208 177126 29361141
Chronic allograft nephropathy 89.57 12.56 38 36222 1082 29537185
Apoptosis 82.13 12.56 24 36236 214 29538053
Proteinuria 78.69 12.56 97 36163 15707 29522560
Off label use 75.48 12.56 627 35633 300173 29238094
Lymphocyte count decreased 75.33 12.56 105 36155 19166 29519101
Fatigue 74.54 12.56 175 36085 316646 29221621
Klebsiella infection 74.48 12.56 66 36194 7283 29530984
Strongyloidiasis 74.08 12.56 42 36218 2270 29535997
Renal impairment 72.55 12.56 242 36018 81091 29457176
Renal artery stenosis 72.09 12.56 39 36221 1922 29536345
Rash 70.90 12.56 77 36183 189742 29348525
Malacoplakia 70.88 12.56 19 36241 119 29538148
Lymphocele 70.87 12.56 34 36226 1298 29536969
Focal segmental glomerulosclerosis 69.40 12.56 37 36223 1770 29536497
Enterococcal infection 67.83 12.56 66 36194 8202 29530065
Blastomycosis 67.53 12.56 22 36238 290 29537977
Cystitis haemorrhagic 66.81 12.56 52 36208 4790 29533477
Pulmonary nocardiosis 65.27 12.56 25 36235 542 29537725
Septic shock 64.78 12.56 196 36064 62364 29475903
Acute kidney injury 64.36 12.56 549 35711 264718 29273549
Histoplasmosis 64.31 12.56 32 36228 1324 29536943
Pneumonia cryptococcal 64.29 12.56 27 36233 749 29537518
Liver transplant rejection 63.62 12.56 36 36224 1938 29536329
Pneumocystis jirovecii pneumonia 63.47 12.56 90 36170 16689 29521578
Graft loss 61.99 12.56 27 36233 821 29537446
Aplasia pure red cell 61.07 12.56 52 36208 5439 29532828
Pneumonia cytomegaloviral 60.76 12.56 39 36221 2643 29535624
Acinetobacter infection 60.25 12.56 28 36232 994 29537273
Pain 60.25 12.56 73 36187 171359 29366908
Red blood cells urine positive 57.98 12.56 32 36228 1641 29536626
Progressive multifocal leukoencephalopathy 57.71 12.56 62 36198 8657 29529610
Encephalitis viral 57.52 12.56 28 36232 1104 29537163
Malignant neoplasm progression 56.45 12.56 11 36249 73848 29464419
Infection reactivation 55.57 12.56 27 36233 1060 29537207
Diabetes mellitus 55.35 12.56 139 36121 39692 29498575
Urinary tract infection 54.77 12.56 204 36056 72150 29466117
Rhodococcus infection 53.85 12.56 16 36244 152 29538115
Cytomegalovirus colitis 53.71 12.56 35 36225 2434 29535833
Pruritus 53.67 12.56 39 36221 116810 29421457
Dizziness 52.77 12.56 95 36165 189589 29348678
Polyomavirus viraemia 51.83 12.56 22 36238 627 29537640
Renal tubular necrosis 51.53 12.56 75 36185 14240 29524027
Depression 51.44 12.56 20 36240 85127 29453140
Posterior reversible encephalopathy syndrome 51.11 12.56 59 36201 8917 29529350
Cryptosporidiosis infection 50.21 12.56 19 36241 398 29537869
Neutrophil count increased 49.84 12.56 75 36185 14667 29523600
Adenovirus infection 49.22 12.56 42 36218 4405 29533862
Scedosporium infection 47.81 12.56 22 36238 763 29537504
Disseminated cryptococcosis 47.73 12.56 25 36235 1153 29537114
Alternaria infection 47.11 12.56 17 36243 310 29537957
Graft versus host disease in lung 46.82 12.56 19 36241 482 29537785
Haemophagocytic lymphohistiocytosis 46.79 12.56 61 36199 10443 29527824
Acanthamoeba infection 46.58 12.56 18 36242 400 29537867
Acute respiratory distress syndrome 46.42 12.56 93 36167 22842 29515425
Ureteric stenosis 46.12 12.56 24 36236 1092 29537175
Graft versus host disease in skin 45.99 12.56 36 36224 3343 29534924
Arthralgia 45.37 12.56 63 36197 139554 29398713
Protein urine present 45.28 12.56 41 36219 4653 29533614
Constipation 45.18 12.56 44 36216 114116 29424151
Brain abscess 44.40 12.56 32 36228 2623 29535644
Gastroenteritis norovirus 43.76 12.56 25 36235 1371 29536896
Syncope 43.10 12.56 23 36237 81348 29456919
Hydronephrosis 42.51 12.56 53 36207 8677 29529590
Graft versus host disease 41.47 12.56 55 36205 9573 29528694
Graft versus host disease in gastrointestinal tract 40.69 12.56 33 36227 3225 29535042
Escherichia urinary tract infection 40.55 12.56 32 36228 3007 29535260
Trichodysplasia spinulosa 39.87 12.56 14 36246 235 29538032
Basal cell carcinoma 39.66 12.56 73 36187 16837 29521430
American trypanosomiasis 39.59 12.56 14 36246 240 29538027
Escherichia infection 39.42 12.56 45 36215 6719 29531548
Lymphopenia 39.02 12.56 64 36196 13469 29524798
Diffuse large B-cell lymphoma 38.70 12.56 43 36217 6233 29532034
Anxiety 38.52 12.56 29 36231 85336 29452931
Drug hypersensitivity 38.23 12.56 18 36242 68388 29469879
Hyperhidrosis 37.61 12.56 16 36244 64524 29473743
Epstein-Barr viraemia 37.49 12.56 20 36240 958 29537309
Dermatophytosis 37.48 12.56 13 36247 210 29538057
Blood urea increased 36.86 12.56 96 36164 28016 29510251
Squamous cell carcinoma 35.86 12.56 53 36207 10198 29528069
Pancreas transplant rejection 35.79 12.56 12 36248 174 29538093
Viraemia 35.73 12.56 20 36240 1054 29537213
Intraductal papillary mucinous neoplasm 35.62 12.56 14 36246 326 29537941
Urinoma 35.17 12.56 12 36248 184 29538083
Pyelonephritis 35.08 12.56 38 36222 5355 29532912
Dyspnoea 34.97 12.56 246 36014 326486 29211781
Papilloma viral infection 34.84 12.56 15 36245 443 29537824
Histoplasmosis disseminated 34.56 12.56 20 36240 1124 29537143
Renal tubular injury 34.49 12.56 17 36243 689 29537578
Acute graft versus host disease 34.37 12.56 39 36221 5785 29532482
Coronavirus infection 34.25 12.56 30 36230 3258 29535009
Smooth muscle cell neoplasm 34.05 12.56 11 36249 141 29538126
Histology abnormal 33.93 12.56 13 36247 282 29537985
Malacoplakia gastrointestinal 33.66 12.56 10 36250 95 29538172
Decreased appetite 33.46 12.56 81 36179 145261 29393006
Somnolence 32.96 12.56 40 36220 93915 29444352
Respiratory failure 32.43 12.56 217 36043 96914 29441353
Candida infection 32.33 12.56 63 36197 15162 29523105
Chronic graft versus host disease in skin 32.02 12.56 17 36243 806 29537461
Chronic graft versus host disease in liver 31.96 12.56 13 36247 332 29537935
Squamous cell carcinoma of skin 31.69 12.56 48 36212 9438 29528829
Chronic obstructive pulmonary disease 31.49 12.56 6 36254 40949 29497318
Trichophytosis 31.25 12.56 12 36248 262 29538005
Renal transplant 30.54 12.56 21 36239 1597 29536670
Graft versus host disease in liver 30.21 12.56 18 36242 1068 29537199
Mycobacterial infection 30.20 12.56 22 36238 1834 29536433
Varicella zoster virus infection 29.97 12.56 20 36240 1448 29536819
Myocardial infarction 29.95 12.56 56 36204 110240 29428027
Meningitis cryptococcal 29.95 12.56 23 36237 2077 29536190
Necrotising oesophagitis 29.84 12.56 14 36246 508 29537759
Epistaxis 29.83 12.56 13 36247 51691 29486576
Donor specific antibody present 29.79 12.56 9 36251 91 29538176
Pyelonephritis acute 29.78 12.56 21 36239 1663 29536604
Immune reconstitution inflammatory syndrome 29.72 12.56 42 36218 7760 29530507
Febrile neutropenia 29.59 12.56 58 36202 112182 29426085
Large intestinal ulcer 29.50 12.56 21 36239 1688 29536579
Heart transplant rejection 29.24 12.56 18 36242 1133 29537134
Intentional product misuse 29.06 12.56 4 36256 34657 29503610
Erythema 28.91 12.56 30 36230 75576 29462691
Postoperative thoracic procedure complication 28.71 12.56 7 36253 28 29538239
Cardiac failure congestive 28.59 12.56 31 36229 76550 29461717
Neutrophil count decreased 28.42 12.56 9 36251 43558 29494709
Pneumonia escherichia 27.95 12.56 12 36248 352 29537915
Rectal prolapse 27.83 12.56 11 36249 260 29538007
Meningoencephalitis amoebic 27.74 12.56 9 36251 117 29538150
Isosporiasis 27.72 12.56 8 36252 68 29538199
Hernial eventration 27.72 12.56 8 36252 68 29538199
Asthenia 27.67 12.56 153 36107 215097 29323170
Coronary artery disease 27.31 12.56 10 36250 44180 29494087
Gastroenteritis sapovirus 27.07 12.56 9 36251 127 29538140
Epstein-Barr virus associated lymphoproliferative disorder 26.92 12.56 20 36240 1718 29536549
Renal cyst haemorrhage 26.72 12.56 12 36248 393 29537874
Malaise 26.70 12.56 103 36157 159499 29378768
Acute myocardial infarction 26.67 12.56 13 36247 48425 29489842
Cerebral aspergillosis 26.54 12.56 18 36242 1338 29536929
Hypersensitivity 26.50 12.56 16 36244 52887 29485380
Vena cava injury 26.49 12.56 10 36250 208 29538059
Ventricular remodelling 26.29 12.56 8 36252 83 29538184
Neuropathy peripheral 26.24 12.56 29 36231 70998 29467269
Nausea 26.14 12.56 228 36032 289027 29249240
SARS-CoV-2 antibody test positive 25.84 12.56 10 36250 223 29538044
Anogenital warts 25.81 12.56 13 36247 552 29537715
Renal vein thrombosis 25.74 12.56 9 36251 149 29538118
Human herpesvirus 6 infection 25.68 12.56 20 36240 1843 29536424
Chronic graft versus host disease 25.52 12.56 28 36232 4001 29534266
Wrong technique in product usage process 25.49 12.56 4 36256 31424 29506843
Urticaria 25.39 12.56 18 36242 54642 29483625
Transplantation complication 25.32 12.56 8 36252 95 29538172
Actinic keratosis 25.19 12.56 27 36233 3759 29534508
Renal graft infection 25.16 12.56 10 36250 240 29538027
Glomerulonephritis 25.08 12.56 19 36241 1681 29536586
Encephalitis 25.06 12.56 35 36225 6395 29531872
Hypotension 25.05 12.56 138 36122 194216 29344051
Perinephric collection 25.00 12.56 9 36251 163 29538104
Non-cirrhotic portal hypertension 24.93 12.56 10 36250 246 29538021
Gastrointestinal mucormycosis 24.52 12.56 8 36252 106 29538161
Drug interaction 24.38 12.56 358 35902 197027 29341240
Procedural pain 24.33 12.56 28 36232 4216 29534051
Immunosuppressant drug level decreased 24.18 12.56 16 36244 1142 29537125
Hyperkalaemia 24.11 12.56 143 36117 61249 29477018
Foetal exposure during pregnancy 23.93 12.56 6 36254 33861 29504406
Blood pressure decreased 23.85 12.56 13 36247 45464 29492803
Diarrhoea 23.80 12.56 554 35706 332144 29206123
Cholangitis 23.58 12.56 37 36223 7500 29530767
Muscle spasms 23.58 12.56 27 36233 65055 29473212
Glomerulonephritis membranoproliferative 23.55 12.56 11 36249 395 29537872
Joint swelling 23.50 12.56 16 36244 49614 29488653
Mycobacterium haemophilum infection 23.36 12.56 6 36254 31 29538236
Cytomegalovirus oesophagitis 23.29 12.56 11 36249 405 29537862
Meningoencephalitis viral 23.19 12.56 8 36252 127 29538140
Urinary tract infection bacterial 23.08 12.56 17 36243 1441 29536826
Cardio-respiratory arrest 23.06 12.56 17 36243 50584 29487683
Inappropriate schedule of product administration 22.91 12.56 13 36247 44459 29493808
Corynebacterium infection 22.90 12.56 11 36249 421 29537846
Vesicoureteral reflux surgery 22.82 12.56 4 36256 0 29538267
Myopathy toxic 22.78 12.56 11 36249 426 29537841
Postoperative wound infection 22.71 12.56 27 36233 4209 29534058
Seroma 22.57 12.56 12 36248 571 29537696
Parvovirus infection 22.50 12.56 11 36249 438 29537829
Fungal infection 22.49 12.56 51 36209 13634 29524633
Insomnia 22.42 12.56 47 36213 88714 29449553
Nasal cavity cancer 22.37 12.56 8 36252 142 29538125
Haemolytic uraemic syndrome 22.36 12.56 19 36241 1981 29536286
Blood creatine phosphokinase increased 22.23 12.56 11 36249 40633 29497634
Bacterial infection 22.12 12.56 49 36211 12899 29525368
Pain in extremity 22.04 12.56 66 36194 110367 29427900
Disseminated mucormycosis 22.03 12.56 10 36250 336 29537931
Renal tubular acidosis 21.96 12.56 18 36242 1785 29536482
Philadelphia positive chronic myeloid leukaemia 21.86 12.56 7 36253 87 29538180
Aortic pseudoaneurysm 21.81 12.56 6 36254 42 29538225
Bacterial pyelonephritis 21.66 12.56 9 36251 243 29538024
Catatonia 21.55 12.56 27 36233 4441 29533826
Cutaneous malacoplakia 21.45 12.56 6 36254 45 29538222
International normalised ratio increased 21.42 12.56 14 36246 44358 29493909
Histoplasmosis cutaneous 21.14 12.56 5 36255 17 29538250
Pneumonia pseudomonal 21.10 12.56 23 36237 3264 29535003
Pneumocystis jirovecii infection 20.96 12.56 16 36244 1432 29536835
Human herpesvirus 8 infection 20.89 12.56 13 36247 834 29537433
Tubulointerstitial nephritis 20.86 12.56 58 36202 17585 29520682
Infective aortitis 20.71 12.56 5 36255 19 29538248
Musculoskeletal stiffness 20.70 12.56 10 36250 37448 29500819
Metastatic squamous cell carcinoma 20.67 12.56 10 36250 389 29537878
Seizure 20.55 12.56 53 36207 93070 29445197
Infected lymphocele 20.50 12.56 5 36255 20 29538247
Back pain 20.50 12.56 61 36199 102223 29436044
Product dose omission issue 20.41 12.56 56 36204 96327 29441940
Asthma 20.35 12.56 8 36252 33841 29504426
Lung transplant 20.28 12.56 17 36243 1739 29536528
Pathogen resistance 20.25 12.56 36 36224 8080 29530187
Lung transplant rejection 20.14 12.56 12 36248 712 29537555
Leishmaniasis 20.06 12.56 9 36251 294 29537973
Necrotising fasciitis fungal 19.94 12.56 5 36255 23 29538244
Prophylaxis against transplant rejection 19.94 12.56 5 36255 23 29538244
Paraesthesia 19.87 12.56 22 36238 53823 29484444
Platelet count decreased 19.86 12.56 64 36196 104608 29433659
Hypoglycaemia 19.85 12.56 18 36242 48328 29489939
Anti-erythropoietin antibody negative 19.71 12.56 8 36252 203 29538064
Drug reaction with eosinophilia and systemic symptoms 19.70 12.56 5 36255 27987 29510280
Intra-abdominal haemorrhage 19.62 12.56 18 36242 2077 29536190
Suicidal ideation 19.60 12.56 9 36251 34707 29503560
Disease recurrence 19.49 12.56 53 36207 15861 29522406
Electrocardiogram QT prolonged 19.44 12.56 10 36250 36127 29502140
Alveolar proteinosis 19.43 12.56 9 36251 317 29537950
Optic discs blurred 19.24 12.56 6 36254 68 29538199
Metabolic acidosis 19.03 12.56 94 36166 37568 29500699
Suicide attempt 19.01 12.56 9 36251 34101 29504166
Chest pain 18.88 12.56 72 36188 111901 29426366
Mediastinitis 18.81 12.56 11 36249 630 29537637
Depressed level of consciousness 18.74 12.56 11 36249 36931 29501336
Urosepsis 18.73 12.56 41 36219 10705 29527562
Cytomegalovirus mucocutaneous ulcer 18.71 12.56 6 36254 75 29538192
Secondary immunodeficiency 18.70 12.56 9 36251 346 29537921
Mouth ulceration 18.61 12.56 40 36220 10315 29527952
Post procedural urine leak 18.52 12.56 7 36253 146 29538121
Impaired healing 18.49 12.56 47 36213 13511 29524756
Hemianopia heteronymous 18.43 12.56 5 36255 33 29538234
Heart rate decreased 18.42 12.56 4 36256 24908 29513359
IgA nephropathy 18.26 12.56 13 36247 1045 29537222
Visceral leishmaniasis 18.24 12.56 10 36250 506 29537761
Neurotoxicity 18.23 12.56 49 36211 14564 29523703
Feeling abnormal 18.23 12.56 24 36236 54421 29483846
Periostitis 18.19 12.56 8 36252 249 29538018
Anorectal varices 18.17 12.56 5 36255 35 29538232
Enterobacter infection 18.13 12.56 17 36243 2017 29536250
Complications of transplanted heart 18.04 12.56 8 36252 254 29538013
Haemoglobinaemia 17.97 12.56 7 36253 159 29538108
Disseminated varicella zoster virus infection 17.97 12.56 7 36253 159 29538108
Eccrine squamous syringometaplasia 17.93 12.56 5 36255 37 29538230
Acute graft versus host disease in intestine 17.92 12.56 18 36242 2323 29535944
Acute graft versus host disease in skin 17.60 12.56 25 36235 4639 29533628
Fungal skin infection 17.56 12.56 18 36242 2380 29535887
Incisional hernia 17.54 12.56 13 36247 1113 29537154
Aggression 17.45 12.56 11 36249 35530 29502737
Bacterial sepsis 17.44 12.56 25 36235 4678 29533589
Hyperparathyroidism 17.42 12.56 13 36247 1124 29537143
Acinetobacter bacteraemia 17.29 12.56 6 36254 97 29538170
Retinal artery occlusion 17.29 12.56 15 36245 1608 29536659
Transmission of an infectious agent via transplant 17.29 12.56 4 36256 12 29538255
Delusion of grandeur 17.12 12.56 9 36251 418 29537849
Ureteral catheterisation 17.12 12.56 3 36257 0 29538267
Biliary anastomosis complication 17.01 12.56 6 36254 102 29538165
Cardiac failure 16.83 12.56 46 36214 79241 29459026
Hallucination 16.79 12.56 18 36242 44694 29493573
Mycobacterium chelonae infection 16.71 12.56 10 36250 598 29537669
Balance disorder 16.68 12.56 12 36248 36158 29502109
End stage renal disease 16.62 12.56 32 36228 7632 29530635
Urinary fistula 16.60 12.56 6 36254 110 29538157
Nephrostomy 16.57 12.56 7 36253 197 29538070
Glomerulonephritis proliferative 16.47 12.56 7 36253 200 29538067
Multiple organ dysfunction syndrome 16.46 12.56 133 36127 62983 29475284
Loss of consciousness 16.45 12.56 42 36218 74014 29464253
Cytomegalovirus nephritis 16.25 12.56 6 36254 117 29538150
Pneumonia klebsiella 16.10 12.56 18 36242 2626 29535641
Renal lymphocele 16.09 12.56 5 36255 56 29538211
Diverticulum intestinal 16.06 12.56 20 36240 3270 29534997
Dysgeusia 16.05 12.56 4 36256 22670 29515597
Argentine haemorrhagic fever 16.02 12.56 4 36256 18 29538249
Gait disturbance 15.98 12.56 42 36218 73307 29464960
Oesophageal stenosis 15.98 12.56 14 36246 1521 29536746
Chronic hepatitis C 15.94 12.56 8 36252 337 29537930
Agitation 15.80 12.56 24 36236 51280 29486987
Respiratory arrest 15.70 12.56 6 36254 25827 29512440
Human polyomavirus infection 15.53 12.56 10 36250 681 29537586
Rhabdomyolysis 15.51 12.56 32 36228 60776 29477491
Staphylococcal infection 15.50 12.56 74 36186 29166 29509101
Upper gastrointestinal haemorrhage 15.26 12.56 4 36256 21910 29516357
Chronic kidney disease-mineral and bone disorder 15.25 12.56 8 36252 370 29537897
Lymphorrhoea 15.20 12.56 5 36255 68 29538199
Cardiac disorder 15.14 12.56 14 36246 37249 29501018
White blood cell count decreased 15.10 12.56 52 36208 83310 29454957
Pyrexia 15.06 12.56 460 35800 287162 29251105
Serratia infection 15.06 12.56 10 36250 718 29537549
Abdominal wall haemorrhage 15.05 12.56 7 36253 249 29538018
Balamuthia infection 15.04 12.56 3 36257 3 29538264
Propionibacterium infection 14.97 12.56 7 36253 252 29538015
Gastrointestinal mucosa hyperaemia 14.82 12.56 7 36253 258 29538009
Graft thrombosis 14.82 12.56 7 36253 258 29538009
Pupillary deformity 14.79 12.56 4 36256 26 29538241
Lymphadenitis fungal 14.58 12.56 3 36257 4 29538263
Epstein-Barr virus associated lymphoma 14.56 12.56 9 36251 571 29537696
Vocal cord thickening 14.54 12.56 4 36256 28 29538239
Cranial nerve paralysis 14.42 12.56 4 36256 29 29538238
Rheumatoid arthritis 14.39 12.56 11 36249 32141 29506126
Herpes zoster cutaneous disseminated 14.33 12.56 6 36254 165 29538102
Hospitalisation 14.29 12.56 101 36159 45887 29492380
Peripheral swelling 14.27 12.56 36 36224 63703 29474564
Injury 14.20 12.56 3 36257 19043 29519224
Flushing 14.19 12.56 9 36251 28983 29509284
New onset diabetes after transplantation 14.18 12.56 4 36256 31 29538236
Wound dehiscence 14.18 12.56 18 36242 2999 29535268
Bilirubin conjugated increased 14.18 12.56 18 36242 2999 29535268
Angioedema 14.18 12.56 11 36249 31904 29506363
Leuconostoc infection 14.18 12.56 3 36257 5 29538262
Arteriovenous fistula aneurysm 14.18 12.56 3 36257 5 29538262
Gastroenteritis cryptosporidial 14.17 12.56 6 36254 170 29538097
Brain compression 14.10 12.56 6 36254 172 29538095
Functional gastrointestinal disorder 14.07 12.56 15 36245 2075 29536192
Pancreas transplant 14.07 12.56 4 36256 32 29538235
Nephrosclerosis 14.05 12.56 10 36250 804 29537463
Hyperparathyroidism secondary 14.02 12.56 12 36248 1263 29537004
Herpes simplex hepatitis 14.02 12.56 5 36255 88 29538179
Neuroendocrine carcinoma of the skin 14.00 12.56 9 36251 611 29537656
Pyuria 13.80 12.56 9 36251 627 29537640
Legionella infection 13.77 12.56 8 36252 453 29537814
Immunoglobulin G4 related disease 13.76 12.56 4 36256 35 29538232
Abdominal wall abscess 13.72 12.56 8 36252 456 29537811
Oesophageal ulcer 13.71 12.56 18 36242 3102 29535165
Passenger lymphocyte syndrome 13.56 12.56 4 36256 37 29538230
Scleroderma 13.52 12.56 12 36248 1326 29536941
Drug level fluctuating 13.36 12.56 8 36252 479 29537788
Capillaritis 13.29 12.56 5 36255 103 29538164
Enterovirus infection 13.28 12.56 9 36251 668 29537599
Drug resistance 13.27 12.56 57 36203 21483 29516784
Confusional state 13.26 12.56 97 36163 127780 29410487
Endocarditis viral 13.23 12.56 3 36257 8 29538259
Transitional cell carcinoma 13.23 12.56 14 36246 1921 29536346
Nodular regenerative hyperplasia 13.21 12.56 9 36251 674 29537593
Cytomegalovirus gastroenteritis 13.21 12.56 6 36254 202 29538065
Bordetella infection 13.20 12.56 5 36255 105 29538162
Gingival hypertrophy 13.11 12.56 13 36247 1652 29536615
Drug withdrawal syndrome 13.07 12.56 3 36257 17981 29520286
Biopsy kidney abnormal 12.98 12.56 5 36255 110 29538157
Pneumonia proteus 12.97 12.56 3 36257 9 29538258
Small intestine gangrene 12.97 12.56 3 36257 9 29538258
Disease progression 12.96 12.56 54 36206 81862 29456405
Herpes zoster oticus 12.94 12.56 5 36255 111 29538156
Phaeohyphomycotic brain abscess 12.94 12.56 4 36256 44 29538223
Cytomegalovirus gastritis 12.94 12.56 6 36254 212 29538055
Cytomegalovirus syndrome 12.90 12.56 5 36255 112 29538155
Toxoplasmosis 12.87 12.56 11 36249 1156 29537111
Streptococcal endocarditis 12.85 12.56 4 36256 45 29538222
Superinfection bacterial 12.83 12.56 9 36251 707 29537560
Liver transplant 12.81 12.56 15 36245 2301 29535966
Stomatitis 12.79 12.56 16 36244 37097 29501170
Carotid arteriosclerosis 12.78 12.56 12 36248 1426 29536841
Stenotrophomonas infection 12.77 12.56 13 36247 1704 29536563
Narrow anterior chamber angle 12.74 12.56 5 36255 116 29538151
Chemical peritonitis 12.66 12.56 5 36255 118 29538149
Central nervous system lymphoma 12.63 12.56 9 36251 725 29537542
Cerebrovascular accident 12.60 12.56 50 36210 76861 29461406
Urine output decreased 12.57 12.56 32 36228 9206 29529061

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Cytomegalovirus infection 1119.03 11.27 587 58656 36612 64402877
Kidney transplant rejection 870.78 11.27 328 58915 9183 64430306
Transplant rejection 857.10 11.27 385 58858 17016 64422473
Post transplant lymphoproliferative disorder 664.77 11.27 270 58973 9274 64430215
Complications of transplanted kidney 599.36 11.27 215 59028 5220 64434269
COVID-19 593.38 11.27 486 58757 64654 64374835
Polyomavirus-associated nephropathy 511.43 11.27 186 59057 4702 64434787
Immunosuppressant drug level increased 407 11.27 176 59067 7083 64432406
BK virus infection 406.73 11.27 177 59066 7235 64432254
Thrombotic microangiopathy 374.17 11.27 217 59026 16438 64423051
Cytomegalovirus viraemia 337.01 11.27 175 59068 10653 64428836
Product use in unapproved indication 321.37 11.27 579 58664 176039 64263450
Delayed graft function 286.14 11.27 107 59136 2929 64436560
Epstein-Barr virus infection 262.82 11.27 156 59087 12332 64427157
Parvovirus B19 infection 261.41 11.27 80 59163 1159 64438330
Transplant dysfunction 260.55 11.27 126 59117 6582 64432907
Leukopenia 259.98 11.27 388 58855 100854 64338635
Blood creatinine increased 245.36 11.27 444 58799 135338 64304151
Renal transplant failure 239.35 11.27 80 59163 1560 64437929
Aspergillus infection 238.24 11.27 162 59081 16217 64423272
Off label use 218.71 11.27 1150 58093 631656 63807833
West Nile viral infection 205.40 11.27 62 59181 855 64438634
JC virus infection 193.49 11.27 83 59160 3272 64436217
Posterior reversible encephalopathy syndrome 191.68 11.27 163 59080 22783 64416706
Cryptococcosis 188.56 11.27 77 59166 2678 64436811
Renal impairment 175.74 11.27 385 58858 134632 64304857
Pneumocystis jirovecii pneumonia 169.41 11.27 165 59078 27469 64412020
Drug level increased 162.36 11.27 178 59065 34018 64405471
Nephropathy toxic 162.03 11.27 132 59111 17382 64422107
Phaeohyphomycosis 155.18 11.27 52 59191 1022 64438467
Chronic allograft nephropathy 152.12 11.27 56 59187 1465 64438024
Apoptosis 151.70 11.27 39 59204 283 64439206
Incision site pain 147.61 11.27 64 59179 2590 64436899
Bronchopulmonary aspergillosis 144.11 11.27 128 59115 18957 64420532
Fall 143.98 11.27 104 59139 416722 64022767
Nocardiosis 142.48 11.27 75 59168 4692 64434797
Pain 142.43 11.27 180 59063 553331 63886158
Fatigue 140.12 11.27 300 58943 748430 63691059
Mucormycosis 137.20 11.27 85 59158 7256 64432233
Acute kidney injury 136.93 11.27 790 58453 448450 63991039
Graft versus host disease in skin 134.40 11.27 75 59168 5272 64434217
Histoplasmosis 133.23 11.27 55 59188 1967 64437522
Epstein-Barr viraemia 129.08 11.27 52 59191 1745 64437744
Graft versus host disease in gastrointestinal tract 128.34 11.27 74 59169 5538 64433951
Histoplasmosis disseminated 127.10 11.27 53 59190 1945 64437544
Lymphocele 126.61 11.27 50 59193 1591 64437898
Focal segmental glomerulosclerosis 125.61 11.27 59 59184 2885 64436604
Pseudomonas infection 123.36 11.27 114 59129 17769 64421720
Graft loss 123.03 11.27 43 59200 964 64438525
Blastomycosis 121.92 11.27 36 59207 458 64439031
Trichodysplasia spinulosa 120.89 11.27 39 59204 677 64438812
Adenovirus infection 120.59 11.27 78 59165 7177 64432312
Transplant failure 119.99 11.27 62 59181 3732 64435757
Varicella zoster virus infection 118.56 11.27 62 59181 3826 64435663
Klebsiella infection 118.46 11.27 98 59145 13183 64426306
Renal tubular atrophy 115.92 11.27 46 59197 1483 64438006
Aplasia pure red cell 115.58 11.27 75 59168 6939 64432550
Kidney fibrosis 113.68 11.27 56 59187 3045 64436444
Liver transplant rejection 112.45 11.27 55 59188 2944 64436545
Cytomegalovirus colitis 112.31 11.27 60 59183 3868 64435621
Arthralgia 111.40 11.27 146 59097 442114 63997375
Escherichia infection 109.13 11.27 99 59144 15069 64424420
Polyomavirus viraemia 106.03 11.27 40 59203 1122 64438367
Hepatitis E 104.59 11.27 49 59194 2382 64437107
Rash 104.01 11.27 163 59080 458386 63981103
Septic shock 102.91 11.27 269 58974 105168 64334321
Cystitis haemorrhagic 102.36 11.27 73 59170 7883 64431606
Enterococcal infection 100.73 11.27 91 59152 13775 64425714
COVID-19 pneumonia 100.12 11.27 98 59145 16406 64423083
Diabetes mellitus 99.71 11.27 201 59042 66273 64373216
Proteinuria 97.84 11.27 124 59119 27599 64411890
Diffuse large B-cell lymphoma 97.75 11.27 79 59164 10282 64429207
Progressive multifocal leukoencephalopathy 97.30 11.27 101 59142 18131 64421358
Strongyloidiasis 93.44 11.27 49 59194 3041 64436448
Renal tubular necrosis 91.18 11.27 107 59136 22003 64417486
Disseminated cryptococcosis 91.13 11.27 39 59204 1528 64437961
Respiratory failure 91.04 11.27 340 58903 160843 64278646
Drug hypersensitivity 90.61 11.27 53 59190 237762 64201727
Malacoplakia 88.01 11.27 24 59219 224 64439265
Human herpesvirus 6 infection 87.25 11.27 54 59189 4600 64434889
Haemophagocytic lymphohistiocytosis 85.90 11.27 93 59150 17516 64421973
Multiple organ dysfunction syndrome 85.27 11.27 245 58998 101168 64338321
Pruritus 83.96 11.27 98 59145 312302 64127187
Rhodococcus infection 83.28 11.27 23 59220 226 64439263
Dizziness 83.02 11.27 169 59074 429994 64009495
Acute respiratory distress syndrome 82.85 11.27 137 59106 38798 64400691
Graft versus host disease 81.89 11.27 81 59162 13732 64425757
Pneumonia cytomegaloviral 80.47 11.27 50 59193 4289 64435200
Infection reactivation 78.43 11.27 38 59205 1992 64437497
Tubulointerstitial nephritis 77.14 11.27 117 59126 30792 64408697
Arthropathy 77.12 11.27 10 59233 120957 64318532
Neutrophil count increased 75.55 11.27 104 59139 25070 64414419
Brain abscess 74.57 11.27 47 59196 4134 64435355
Lymphocyte count decreased 74.53 11.27 134 59109 40565 64398924
Injection site pain 71.53 11.27 9 59234 111399 64328090
Protein urine present 71.48 11.27 62 59181 8894 64430595
Joint swelling 71.33 11.27 56 59187 215326 64224163
Hypersensitivity 70.37 11.27 47 59196 196405 64243084
Gastroenteritis norovirus 69.95 11.27 39 59204 2736 64436753
Pancreas transplant rejection 69.87 11.27 21 59222 285 64439204
Depression 69.58 11.27 41 59202 183250 64256239
Anxiety 69.26 11.27 51 59192 202598 64236891
Renal artery stenosis 67.49 11.27 39 59204 2930 64436559
Graft versus host disease in lung 67.34 11.27 26 59217 778 64438711
Encephalitis viral 67.05 11.27 36 59207 2344 64437145
Red blood cells urine positive 66.79 11.27 45 59198 4433 64435056
Scedosporium infection 65.71 11.27 29 59214 1225 64438264
Lymphopenia 65.28 11.27 98 59145 25559 64413930
Acanthamoeba infection 64.20 11.27 22 59221 464 64439025
Malignant neoplasm progression 63.75 11.27 13 59230 112858 64326631
Malacoplakia gastrointestinal 62.12 11.27 17 59226 161 64439328
Viraemia 61.92 11.27 34 59209 2315 64437174
Renal tubular injury 61.32 11.27 27 59216 1134 64438355
Intentional overdose 60.93 11.27 6 59237 89938 64349551
Pneumonia cryptococcal 59.64 11.27 27 59216 1212 64438277
Blood urea increased 58.59 11.27 127 59116 44026 64395463
Human polyomavirus infection 58.07 11.27 25 59218 994 64438495
Cryptosporidiosis infection 58.05 11.27 22 59221 625 64438864
Malaise 57.51 11.27 180 59063 396067 64043422
Central nervous system lymphoma 56.57 11.27 30 59213 1905 64437584
Alternaria infection 56.42 11.27 21 59222 567 64438922
Urinoma 56.39 11.27 16 59227 175 64439314
Drug interaction 56.15 11.27 543 58700 361540 64077949
Contraindicated product administered 55.79 11.27 15 59228 107814 64331675
American trypanosomiasis 55.61 11.27 18 59225 316 64439173
Ureaplasma infection 55.24 11.27 22 59221 716 64438773
Pulmonary nocardiosis 54.64 11.27 22 59221 737 64438752
Candida infection 54.43 11.27 101 59142 31318 64408171
Escherichia urinary tract infection 54.26 11.27 61 59182 11976 64427513
Synovitis 52.77 11.27 13 59230 99077 64340412
Haemolytic uraemic syndrome 51.97 11.27 37 59206 3984 64435505
Disseminated mucormycosis 51.90 11.27 19 59224 489 64439000
Mycobacterial infection 51.82 11.27 33 59210 2955 64436534
Infusion related reaction 50.46 11.27 46 59197 164421 64275068
Acinetobacter infection 50.20 11.27 30 59213 2399 64437090
Injection site erythema 49.91 11.27 4 59239 70796 64368693
Ureteric stenosis 49.82 11.27 24 59219 1242 64438247
Hydronephrosis 49.55 11.27 63 59180 14062 64425427
Papilloma viral infection 49.42 11.27 25 59218 1439 64438050
Dyspnoea 49.34 11.27 423 58820 718251 63721238
Pain in extremity 48.82 11.27 131 59112 302954 64136535
Constipation 48.64 11.27 85 59158 229252 64210237
Pyelonephritis 48.34 11.27 69 59174 17197 64422292
Graft versus host disease in liver 48.21 11.27 25 59218 1516 64437973
Acute graft versus host disease 47.88 11.27 50 59193 9034 64430455
Coronavirus infection 47.64 11.27 40 59203 5490 64433999
Post transplant distal limb syndrome 47.47 11.27 18 59225 512 64438977
Toxoplasmosis 47.45 11.27 29 59214 2415 64437074
Philadelphia positive chronic myeloid leukaemia 47.42 11.27 13 59230 124 64439365
Immunosuppressant drug level decreased 47.09 11.27 26 59217 1789 64437700
Renal transplant 47.07 11.27 28 59215 2220 64437269
Anogenital warts 46.53 11.27 20 59223 792 64438697
Syncope 46.13 11.27 46 59197 157589 64281900
Human ehrlichiosis 45.35 11.27 16 59227 369 64439120
Insomnia 45.05 11.27 70 59173 197766 64241723
Diarrhoea 44.64 11.27 920 58323 721784 63717705
Donor specific antibody present 44.63 11.27 14 59229 221 64439268
Dermatophytosis 44.52 11.27 16 59227 390 64439099
Meningitis cryptococcal 44.31 11.27 30 59213 2979 64436510
Angiosarcoma 43.88 11.27 16 59227 407 64439082
Rheumatoid arthritis 43.59 11.27 52 59191 164242 64275247
Epstein-Barr virus associated lymphoproliferative disorder 43.33 11.27 30 59213 3089 64436400
Bacterial pyelonephritis 43.31 11.27 17 59226 532 64438957
Squamous cell carcinoma of skin 43.30 11.27 54 59189 11822 64427667
Lung transplant rejection 42.79 11.27 22 59221 1310 64438179
Alveolar proteinosis 42.41 11.27 17 59226 563 64438926
Stomatitis 42.31 11.27 24 59219 109581 64329908
Smooth muscle cell neoplasm 42.09 11.27 19 59224 847 64438642
Therapeutic product effect decreased 42.09 11.27 27 59216 115324 64324165
End stage renal disease 42.04 11.27 50 59193 10425 64429064
Urticaria 41.95 11.27 44 59199 147273 64292216
Chronic graft versus host disease 41.34 11.27 39 59204 6237 64433252
Human herpesvirus 8 infection 41.19 11.27 20 59223 1053 64438436
Contusion 41.14 11.27 27 59216 113938 64325551
Encephalitis 40.86 11.27 54 59189 12517 64426972
Cardiac failure congestive 40.67 11.27 36 59207 130544 64308945
Heart transplant rejection 40.61 11.27 21 59222 1266 64438223
Myocardial infarction 40.36 11.27 56 59187 165765 64273724
Decreased appetite 39.91 11.27 129 59114 281160 64158329
Immune reconstitution inflammatory syndrome 39.66 11.27 53 59190 12417 64427072
Back pain 39.62 11.27 109 59134 250062 64189427
Trichophytosis 39.59 11.27 14 59229 325 64439164
Balance disorder 39.24 11.27 14 59229 83912 64355577
Urinary fistula 39.08 11.27 10 59233 71 64439418
Nausea 39.01 11.27 499 58744 785301 63654188
Asthenia 39.01 11.27 232 59011 427812 64011677
Urinary tract infection 38.68 11.27 353 58890 231243 64208246
Squamous cell carcinoma 38.20 11.27 55 59188 13814 64425675
Erythema 38.16 11.27 71 59172 186999 64252490
Glomerulonephritis 37.97 11.27 27 59216 2901 64436588
Intentional product misuse 37.50 11.27 10 59233 72285 64367204
Gastroenteritis sapovirus 37.18 11.27 11 59232 141 64439348
Peripheral swelling 37.09 11.27 86 59157 209067 64230422
Cytomegalovirus nephritis 37.03 11.27 11 59232 143 64439346
Feeling abnormal 36.82 11.27 41 59202 133561 64305928
Biopsy lung abnormal 36.76 11.27 11 59232 147 64439342
Enterobacter infection 36.61 11.27 29 59214 3667 64435822
Hypogammaglobulinaemia 36.22 11.27 46 59197 10253 64429236
Musculoskeletal stiffness 35.99 11.27 36 59207 123170 64316319
Chronic graft versus host disease in liver 35.83 11.27 15 59228 556 64438933
Hernial eventration 35.80 11.27 9 59234 59 64439430
Gastrointestinal mucormycosis 35.35 11.27 13 59230 339 64439150
Nasopharyngitis 35.26 11.27 80 59163 195993 64243496
Asthma 35.14 11.27 22 59221 95203 64344286
Oesophageal candidiasis 35.07 11.27 40 59203 7977 64431512
Pathogen resistance 34.93 11.27 50 59193 12493 64426996
Suicidal ideation 34.90 11.27 9 59234 66533 64372956
Hyperhidrosis 34.80 11.27 38 59205 124882 64314607
Chronic obstructive pulmonary disease 34.70 11.27 11 59232 71037 64368452
Drug resistance 34.66 11.27 90 59153 35012 64404477
Histoplasmosis cutaneous 34.35 11.27 8 59235 36 64439453
Neutrophil count decreased 34.22 11.27 14 59229 77182 64362307
Bacterial sepsis 33.97 11.27 38 59205 7419 64432070
Alopecia 33.69 11.27 63 59180 165627 64273862
Wrong technique in product usage process 33.68 11.27 9 59234 64965 64374524
Meningoencephalitis amoebic 33.60 11.27 10 59233 131 64439358
Chronic graft versus host disease in skin 33.57 11.27 19 59224 1372 64438117
Pneumocystis jirovecii infection 33.49 11.27 23 59220 2338 64437151
Necrotising oesophagitis 33.10 11.27 15 59228 675 64438814
Mycobacterium avium complex infection 32.91 11.27 28 59215 3912 64435577
Cerebral aspergillosis 32.64 11.27 20 59223 1673 64437816
Chronic kidney disease 32.50 11.27 122 59121 57797 64381692
Oesophageal ulcer 32.41 11.27 34 59209 6176 64433313
Herpes simplex hepatitis 32.39 11.27 13 59230 432 64439057
Wound 32.11 11.27 15 59228 76462 64363027
Stress 32.11 11.27 8 59235 60526 64378963
Pyelonephritis acute 32.10 11.27 31 59212 5103 64434386
Wheezing 32.03 11.27 17 59226 80562 64358927
Actinic keratosis 31.94 11.27 31 59212 5134 64434355
Renal cyst haemorrhage 31.91 11.27 13 59230 449 64439040
Intraductal papillary mucinous neoplasm 31.91 11.27 14 59229 583 64438906
Lung transplant 31.90 11.27 28 59215 4080 64435409
Epstein-Barr virus associated lymphoma 31.69 11.27 16 59227 917 64438572
Hospitalisation 31.64 11.27 145 59098 75062 64364427
Sepsis 31.59 11.27 337 58906 230004 64209485
Mycobacterium haemophilum infection 31.37 11.27 8 59235 56 64439433
Drug reaction with eosinophilia and systemic symptoms 31.12 11.27 6 59237 54211 64385278
Ventricular remodelling 30.88 11.27 9 59234 109 64439380
Discomfort 30.80 11.27 18 59225 80860 64358629
Renal lymphocele 30.66 11.27 9 59234 112 64439377
Disseminated tuberculosis 30.65 11.27 26 59217 3619 64435870
Osteoarthritis 30.59 11.27 10 59233 63326 64376163
Disseminated varicella zoster vaccine virus infection 30.51 11.27 9 59234 114 64439375
Injury 30.49 11.27 7 59236 55985 64383504
Disease recurrence 30.30 11.27 80 59163 31430 64408059
Urinary tract infection bacterial 30.29 11.27 30 59213 5091 64434398
Muscle spasms 30.12 11.27 52 59191 140971 64298518
Malacoplakia vesicae 30.00 11.27 8 59235 68 64439421
Heart rate decreased 29.75 11.27 7 59236 55060 64384429
Oesophageal stenosis 29.51 11.27 26 59217 3808 64435681
Chromoblastomycosis 29.50 11.27 8 59235 73 64439416
Injection site reaction 29.39 11.27 4 59239 46660 64392829
Hypoaesthesia 29.07 11.27 52 59191 139056 64300433
Perinephric collection 29.04 11.27 11 59232 312 64439177
Hypotension 28.91 11.27 218 59025 380756 64058733
Pneumopericardium 28.81 11.27 9 59234 140 64439349
Vena cava injury 28.79 11.27 10 59233 220 64439269
Obliterative bronchiolitis 28.76 11.27 22 59221 2643 64436846
Pyrexia 28.66 11.27 693 58550 557951 63881538
Staphylococcal infection 28.64 11.27 107 59136 50571 64388918
Somnolence 28.44 11.27 94 59149 203551 64235938
Fungal skin infection 28.44 11.27 29 59214 5096 64434393
Biloma 28.35 11.27 9 59234 148 64439341
Swelling 28.29 11.27 66 59177 160152 64279337
Microsporidia infection 28.25 11.27 14 59229 771 64438718
Respiratory arrest 28.11 11.27 7 59236 52978 64386511
Biliary anastomosis complication 28.02 11.27 9 59234 154 64439335
SARS-CoV-2 antibody test positive 28.01 11.27 10 59233 239 64439250
Escherichia pyelonephritis 27.90 11.27 12 59231 476 64439013
Cystitis viral 27.88 11.27 13 59230 625 64438864
Neuroendocrine carcinoma of the skin 27.70 11.27 15 59228 993 64438496
Large intestinal ulcer 27.51 11.27 26 59217 4167 64435322
Gastroenteritis cryptosporidial 27.40 11.27 10 59233 255 64439234
Pancytopenia 27.33 11.27 225 59018 143084 64296405
Cardio-respiratory arrest 27.32 11.27 30 59213 98363 64341126
Electrocardiogram QT prolonged 27.11 11.27 20 59223 79428 64360061
Prophylaxis against transplant rejection 26.97 11.27 7 59236 53 64439436
Atypical haemolytic uraemic syndrome 26.87 11.27 13 59230 679 64438810
Weight increased 26.79 11.27 103 59140 213245 64226244
Suicide attempt 26.76 11.27 16 59227 70991 64368498
Chemical peritonitis 26.73 11.27 10 59233 274 64439215
Chronic hepatitis C 26.67 11.27 12 59231 531 64438958
Paraesthesia 26.60 11.27 52 59191 134470 64305019
Isosporiasis 26.45 11.27 8 59235 111 64439378
Cerebral toxoplasmosis 26.40 11.27 18 59225 1808 64437681
Bacillary angiomatosis 26.34 11.27 9 59234 188 64439301
Cytomegalovirus syndrome 26.26 11.27 10 59233 288 64439201
Necrotising herpetic retinopathy 26.07 11.27 8 59235 117 64439372
Mouth ulceration 25.91 11.27 77 59166 32367 64407122
Bacterial infection 25.70 11.27 65 59178 24885 64414604
Confusional state 25.66 11.27 138 59105 261006 64178483
Complications of transplanted heart 25.66 11.27 10 59233 307 64439182
Neuropathy peripheral 25.41 11.27 43 59200 117482 64322007
Cytomegalovirus hepatitis 25.39 11.27 12 59231 595 64438894
Superinfection bacterial 25.38 11.27 15 59228 1175 64438314
Pneumonia escherichia 25.30 11.27 13 59230 773 64438716
Headache 25.17 11.27 339 58904 529128 63910361
Gait disturbance 25.06 11.27 78 59165 172077 64267412
Encephalitis cytomegalovirus 24.99 11.27 14 59229 991 64438498
Cutaneous malacoplakia 24.97 11.27 7 59236 73 64439416
Rectal prolapse 24.92 11.27 17 59226 1709 64437780
Pulmonary mucormycosis 24.90 11.27 13 59230 799 64438690
Haemoglobin decreased 24.71 11.27 281 58962 194782 64244707
Meningitis bacterial 24.54 11.27 19 59224 2324 64437165
Acute myocardial infarction 24.51 11.27 17 59226 69701 64369788
Injection site pruritus 24.40 11.27 3 59240 37823 64401666
Fungal infection 24.30 11.27 78 59165 34173 64405316
Metabolic acidosis 24.28 11.27 129 59114 70829 64368660
Sinusitis 24.28 11.27 62 59181 145866 64293623
Nephropathy 24.19 11.27 34 59209 8352 64431137
Flushing 24.10 11.27 22 59221 78626 64360863
Pneumonia pseudomonal 24.09 11.27 26 59217 4877 64434612
Lupus nephritis 23.97 11.27 19 59224 2405 64437084
Passenger lymphocyte syndrome 23.85 11.27 7 59236 87 64439402
Mycobacterium chelonae infection 23.85 11.27 18 59225 2119 64437370
Herpes simplex oesophagitis 23.84 11.27 9 59234 253 64439236
Product dose omission issue 23.82 11.27 95 59148 194652 64244837
Cat scratch disease 23.77 11.27 9 59234 255 64439234
Nasal cavity cancer 23.69 11.27 8 59235 161 64439328
Coccidioidomycosis 23.65 11.27 14 59229 1100 64438389
Periostitis 23.65 11.27 11 59232 526 64438963
Inappropriate schedule of product administration 23.63 11.27 30 59213 92256 64347233
Aortic pseudoaneurysm 23.52 11.27 6 59237 42 64439447
Urosepsis 23.21 11.27 58 59185 22036 64417453
Loss of consciousness 23.20 11.27 65 59178 148300 64291189
Blood pressure decreased 23.15 11.27 27 59216 86172 64353317
Infective aortitis 23.05 11.27 6 59237 46 64439443
Mobility decreased 22.93 11.27 27 59216 85813 64353676
Anti-erythropoietin antibody negative 22.86 11.27 9 59234 284 64439205
Postoperative wound infection 22.83 11.27 37 59206 10299 64429190
Human herpesvirus 6 encephalitis 22.80 11.27 10 59233 416 64439073
Epidermodysplasia verruciformis 22.74 11.27 8 59235 183 64439306
Hyperkalaemia 22.73 11.27 165 59078 100964 64338525
Corynebacterium infection 22.70 11.27 13 59230 960 64438529
Fibromyalgia 22.65 11.27 3 59240 35728 64403761
Loss of personal independence in daily activities 22.52 11.27 20 59223 72434 64367055
Renal tubular acidosis 22.52 11.27 20 59223 2959 64436530
Liver abscess 22.51 11.27 26 59217 5254 64434235
Chest pain 22.47 11.27 126 59117 235854 64203635
Acarodermatitis 22.35 11.27 14 59229 1218 64438271
Systemic candida 22.32 11.27 26 59217 5303 64434186
Cytomegalovirus oesophagitis 22.31 11.27 11 59232 599 64438890
Coronary artery disease 22.24 11.27 14 59229 60419 64379070
Hypoglycaemia 22.22 11.27 30 59213 89862 64349627
Metastatic squamous cell carcinoma 22.19 11.27 10 59233 444 64439045
Cytomegalovirus gastrointestinal infection 22.15 11.27 10 59233 446 64439043
Catatonia 22.14 11.27 31 59212 7589 64431900
Blister 22.14 11.27 25 59218 80942 64358547
Hyperuricaemia 21.86 11.27 36 59207 10155 64429334
Postoperative thoracic procedure complication 21.81 11.27 6 59237 58 64439431
Irritable bowel syndrome 21.73 11.27 4 59239 37365 64402124
Acute graft versus host disease in skin 21.59 11.27 29 59214 6826 64432663
Toxic epidermal necrolysis 21.57 11.27 4 59239 37162 64402327
Drug level fluctuating 21.35 11.27 11 59232 658 64438831
Leishmaniasis 21.34 11.27 9 59234 340 64439149
Spindle cell sarcoma 21.32 11.27 8 59235 221 64439268
Necrotising fasciitis fungal 21.20 11.27 5 59238 24 64439465
New onset diabetes after transplantation 21.11 11.27 7 59236 133 64439356
Acute graft versus host disease in intestine 21.09 11.27 21 59222 3588 64435901
Chronic kidney disease-mineral and bone disorder 21.06 11.27 10 59233 501 64438988
Pericarditis 20.99 11.27 16 59227 62500 64376989
Optic discs blurred 20.95 11.27 6 59237 68 64439421
Injection site bruising 20.93 11.27 4 59239 36369 64403120
Diabetic macroangiopathy 20.77 11.27 7 59236 140 64439349
Glomerulonephritis proliferative 20.71 11.27 9 59234 366 64439123
Cytomegalovirus infection reactivation 20.71 11.27 26 59217 5730 64433759
Necrotising fasciitis 20.68 11.27 25 59218 5301 64434188
Emotional distress 20.66 11.27 4 59239 36034 64403455
Drug dependence 20.64 11.27 3 59240 33309 64406180
Hyperparathyroidism secondary 20.37 11.27 17 59226 2313 64437176
Lymphadenitis fungal 20.32 11.27 4 59239 6 64439483
Depressed level of consciousness 20.31 11.27 27 59216 81409 64358080
Epistaxis 20.21 11.27 37 59206 98094 64341395
Meningoencephalitis viral 20.18 11.27 9 59234 390 64439099
Visceral leishmaniasis 20.13 11.27 12 59231 955 64438534
Dysgeusia 20.10 11.27 9 59234 47038 64392451
International normalised ratio increased 19.99 11.27 26 59217 79141 64360348
Complications of transplanted lung 19.90 11.27 9 59234 403 64439086
Renal graft infection 19.88 11.27 9 59234 404 64439085
Eccrine squamous syringometaplasia 19.86 11.27 5 59238 33 64439456
Hepatic fibrosis 19.85 11.27 25 59218 5527 64433962
Disseminated varicella zoster virus infection 19.81 11.27 8 59235 270 64439219
Psoriasis 19.75 11.27 22 59221 71681 64367808
Cytomegalovirus test positive 19.73 11.27 24 59219 5120 64434369
Ureteral necrosis 19.66 11.27 6 59237 86 64439403
Parvovirus infection 19.63 11.27 10 59233 584 64438905
Colitis 19.62 11.27 106 59137 58568 64380921
Anorectal varices 19.60 11.27 5 59238 35 64439454
Mycobacterium abscessus infection 19.60 11.27 12 59231 1002 64438487
Central nervous system lupus 19.49 11.27 8 59235 282 64439207
Serotonin syndrome 19.33 11.27 6 59237 39276 64400213
Lower respiratory tract infection 19.20 11.27 36 59207 94578 64344911
Pneumonia klebsiella 19.13 11.27 21 59222 4016 64435473
Exposure during pregnancy 19.12 11.27 26 59217 77649 64361840
Nosocomial infection 19.12 11.27 17 59226 2520 64436969
Febrile neutropenia 19.08 11.27 98 59145 187559 64251930
Tuberculosis 19.03 11.27 39 59204 12999 64426490
Renal vein thrombosis 19.01 11.27 9 59234 448 64439041
Cytomegalovirus chorioretinitis 18.98 11.27 23 59220 4889 64434600
Histology abnormal 18.90 11.27 8 59235 305 64439184
Liver transplant 18.89 11.27 21 59222 4071 64435418
Propionibacterium infection 18.87 11.27 8 59235 306 64439183
Renal failure 18.80 11.27 252 58991 181436 64258053
Acid base balance abnormal 18.80 11.27 8 59235 309 64439180
Disseminated mycobacterium avium complex infection 18.77 11.27 6 59237 101 64439388
Bilirubin conjugated increased 18.77 11.27 23 59220 4945 64434544
Arthritis 18.73 11.27 30 59213 83784 64355705
Functional gastrointestinal disorder 18.73 11.27 21 59222 4110 64435379
Drug level decreased 18.70 11.27 36 59207 11467 64428022
Abdominal discomfort 18.65 11.27 95 59148 182227 64257262
Hepatitis C 18.56 11.27 35 59208 10980 64428509
Listeriosis 18.54 11.27 15 59228 1955 64437534
Fungaemia 18.47 11.27 20 59223 3765 64435724
Dermatitis papillaris capillitii 18.44 11.27 4 59239 12 64439477
Argentine haemorrhagic fever 18.44 11.27 4 59239 12 64439477
Transmission of an infectious agent via transplant 18.44 11.27 4 59239 12 64439477
Opportunistic infection 18.41 11.27 17 59226 2645 64436844
Vaccination failure 18.40 11.27 11 59232 880 64438609
Blood creatine phosphokinase increased 18.40 11.27 16 59227 58542 64380947
Anti-GAD antibody positive 18.40 11.27 5 59238 46 64439443
Bordetella infection 18.40 11.27 6 59237 108 64439381
Acute graft versus host disease in liver 18.37 11.27 14 59229 1673 64437816
Hallucination 18.28 11.27 24 59219 72764 64366725
Pyelonephritis fungal 18.19 11.27 6 59237 112 64439377
Polyomavirus test positive 18.17 11.27 7 59236 208 64439281
Organising pneumonia 18.11 11.27 31 59212 9024 64430465
IgA nephropathy 18.08 11.27 13 59230 1421 64438068
Transient ischaemic attack 18.04 11.27 9 59234 44173 64395316
Perinephric abscess 18.02 11.27 7 59236 213 64439276
Bronchiectasis 17.99 11.27 40 59203 14100 64425389
Vesicoureteral reflux surgery 17.98 11.27 3 59240 0 64439489
Gingival hypertrophy 17.96 11.27 17 59226 2730 64436759
Respiratory distress 17.81 11.27 95 59148 52236 64387253
Phaeohyphomycotic brain abscess 17.76 11.27 5 59238 53 64439436
Lymphorrhoea 17.71 11.27 6 59237 122 64439367
Serratia infection 17.46 11.27 13 59230 1500 64437989
Emphysematous pyelonephritis 17.46 11.27 7 59236 232 64439257
Acute pulmonary histoplasmosis 17.37 11.27 7 59236 235 64439254
Neurotoxicity 17.30 11.27 60 59183 27344 64412145
Transplantation complication 17.26 11.27 7 59236 239 64439250
Neoplasm progression 17.25 11.27 8 59235 40956 64398533
Dry mouth 17.24 11.27 18 59225 60400 64379089
Herpes simplex 17.16 11.27 33 59210 10503 64428986
Bacteraemia 17.06 11.27 59 59184 26852 64412637
Orthostatic hypotension 16.96 11.27 11 59232 46727 64392762
Haemoglobinaemia 16.86 11.27 7 59236 254 64439235
Drug withdrawal syndrome 16.86 11.27 4 59239 31287 64408202
Haemolytic anaemia 16.72 11.27 42 59201 16011 64423478
Delusion of grandeur 16.69 11.27 9 59234 591 64438898
Plasmapheresis 16.69 11.27 9 59234 591 64438898
Hot flush 16.62 11.27 11 59232 46224 64393265
Aggression 16.62 11.27 11 59232 46221 64393268
Rash pruritic 16.50 11.27 17 59226 57387 64382102
Mucinous adenocarcinoma of appendix 16.36 11.27 4 59239 23 64439466
Agranulocytosis 16.29 11.27 74 59169 38155 64401334
Pneumatosis intestinalis 16.29 11.27 22 59221 5207 64434282
Myopathy toxic 16.16 11.27 10 59233 851 64438638
Hepatic enzyme increased 16.13 11.27 63 59180 129880 64309609
Hyperammonaemia 16.11 11.27 31 59212 9873 64429616
Endocarditis 16.05 11.27 30 59213 9348 64430141
Peritonitis 15.98 11.27 55 59188 24968 64414521
Pneumonia fungal 15.95 11.27 29 59214 8848 64430641
Blood pressure increased 15.95 11.27 93 59150 172459 64267030
Agitation 15.92 11.27 36 59207 88331 64351158
Oral pain 15.87 11.27 3 59240 27490 64411999
Systemic bacterial infection 15.81 11.27 4 59239 27 64439462
Neck pain 15.75 11.27 20 59223 61513 64377976
Hypertriglyceridaemia 15.75 11.27 33 59210 11172 64428317
Incisional hernia 15.74 11.27 14 59229 2076 64437413
Platelet count decreased 15.71 11.27 90 59153 167621 64271868
Pancreatitis necrotising 15.70 11.27 17 59226 3200 64436289
Enterovirus infection 15.66 11.27 12 59231 1445 64438044
Neutropenia 15.66 11.27 308 58935 239316 64200173
Infective tenosynovitis 15.64 11.27 7 59236 306 64439183
Cytomegalovirus mucocutaneous ulcer 15.60 11.27 5 59238 85 64439404
B-cell lymphoma 15.56 11.27 22 59221 5435 64434054
Knee arthroplasty 15.47 11.27 3 59240 26996 64412493
Femur fracture 15.44 11.27 6 59237 34129 64405360
Normocytic anaemia 15.35 11.27 17 59226 3282 64436207
BK polyomavirus test positive 15.28 11.27 5 59238 91 64439398
Tuberculosis gastrointestinal 15.26 11.27 8 59235 496 64438993
Hemianopia heteronymous 15.23 11.27 5 59238 92 64439397
Lymphoproliferative disorder 15.18 11.27 21 59222 5082 64434407
Legionella infection 15.09 11.27 9 59234 717 64438772
Tularaemia 15.08 11.27 5 59238 95 64439394
Bacterial colitis 15.08 11.27 5 59238 95 64439394
Balamuthia infection 15.00 11.27 4 59239 34 64439455
Complications of transplant surgery 14.94 11.27 9 59234 730 64438759
Ejection fraction decreased 14.83 11.27 4 59239 28703 64410786
Pulmonary mass 14.66 11.27 52 59191 23964 64415525
Acinetobacter bacteraemia 14.57 11.27 6 59237 213 64439276
Memory impairment 14.56 11.27 36 59207 85646 64353843
Stenotrophomonas infection 14.55 11.27 16 59227 3064 64436425
Tuberculoma of central nervous system 14.55 11.27 8 59235 546 64438943
Cardiac murmur functional 14.51 11.27 4 59239 39 64439450
Swollen tongue 14.45 11.27 7 59236 34947 64404542
Secondary immunodeficiency 14.37 11.27 15 59228 2709 64436780
Swelling face 14.36 11.27 20 59223 59146 64380343
Fungal sepsis 14.30 11.27 12 59231 1646 64437843
Maternal exposure during pregnancy 14.26 11.27 43 59200 95841 64343648
Pallor 14.25 11.27 9 59234 38772 64400717
Scopulariopsis infection 14.23 11.27 5 59238 114 64439375
Angiocentric lymphoma 14.21 11.27 9 59234 798 64438691
Mediastinitis 14.19 11.27 9 59234 800 64438689
Hypoalbuminaemia 14.16 11.27 42 59201 17632 64421857
Azotaemia 14.11 11.27 25 59218 7477 64432012
Sebaceous carcinoma 14.10 11.27 5 59238 117 64439372
Cardiac failure 14.10 11.27 68 59175 132305 64307184
Endocarditis viral 14.09 11.27 3 59240 8 64439481
Folliculitis 14.08 11.27 5 59238 30072 64409417
Palpitations 14.05 11.27 49 59194 104439 64335050
Anaphylactic reaction 14.04 11.27 26 59217 68638 64370851
Oliguria 14.01 11.27 37 59206 14539 64424950
Sinus tachycardia 14.00 11.27 6 59237 32182 64407307
Helicobacter infection 13.96 11.27 9 59234 38353 64401136
Mycobacterium marinum infection 13.95 11.27 7 59236 396 64439093
Capillaritis 13.95 11.27 6 59237 238 64439251
Cerebrovascular accident 13.89 11.27 72 59171 137511 64301978
Full blood count abnormal 13.84 11.27 5 59238 29752 64409737
Conjunctival neoplasm 13.83 11.27 3 59240 9 64439480
Drug eruption 13.81 11.27 8 59235 36128 64403361
Venous stenosis 13.81 11.27 6 59237 244 64439245
Lip swelling 13.80 11.27 6 59237 31901 64407588
Feeling hot 13.72 11.27 13 59230 45650 64393839
Bacteroides bacteraemia 13.68 11.27 4 59239 49 64439440
Graft thrombosis 13.61 11.27 7 59236 417 64439072
Gastrointestinal mucosa hyperaemia 13.61 11.27 7 59236 417 64439072
Disseminated cytomegaloviral infection 13.60 11.27 7 59236 418 64439071
Abdominal wall haemorrhage 13.60 11.27 7 59236 418 64439071
Hepatic echinococciasis 13.59 11.27 3 59240 10 64439479
CD8 lymphocytes decreased 13.54 11.27 6 59237 256 64439233
Cytomegalovirus gastroenteritis 13.54 11.27 7 59236 422 64439067
Bile duct stenosis 13.53 11.27 12 59231 1772 64437717
Haemodynamic instability 13.47 11.27 37 59206 14875 64424614
Leiomyosarcoma 13.45 11.27 6 59237 260 64439229
Hyperamylasaemia 13.40 11.27 9 59234 882 64438607
Meningitis histoplasma 13.37 11.27 3 59240 11 64439478
Hypervolaemia 13.37 11.27 70 59173 38215 64401274
Graft complication 13.29 11.27 8 59235 648 64438841
Urinary tract candidiasis 13.24 11.27 8 59235 653 64438836
Blood albumin decreased 13.18 11.27 46 59197 21027 64418462
Upper gastrointestinal haemorrhage 13.18 11.27 8 59235 35212 64404277
Palmar-plantar erythrodysaesthesia syndrome 13.14 11.27 5 59238 28814 64410675
Herpes oesophagitis 13.14 11.27 6 59237 275 64439214
Mycoplasma infection 13.14 11.27 8 59235 662 64438827
Aspartate aminotransferase increased 13.07 11.27 61 59182 119727 64319762
Post procedural urine leak 13.06 11.27 5 59238 146 64439343
Medication error 13.04 11.27 16 59227 49950 64389539
Urine output decreased 13.04 11.27 39 59204 16453 64423036
Joint tuberculosis 13.03 11.27 5 59238 147 64439342
Large intestine infection 13.03 11.27 14 59229 2614 64436875
Accidental exposure to product 13.02 11.27 4 59239 26360 64413129
Klebsiella sepsis 13.01 11.27 14 59229 2618 64436871
Purulent pericarditis 13.00 11.27 4 59239 59 64439430
Cognitive disorder 13.00 11.27 19 59224 55068 64384421
Adenoviral hepatitis 12.96 11.27 7 59236 461 64439028
Genital herpes 12.91 11.27 12 59231 1883 64437606
Myeloma cast nephropathy 12.91 11.27 5 59238 151 64439338
Wound complication 12.89 11.27 17 59226 3931 64435558
Steroid diabetes 12.86 11.27 14 59229 2652 64436837
Pancreas transplant 12.82 11.27 4 59239 62 64439427
Glomerulosclerosis 12.75 11.27 9 59234 956 64438533
Dry skin 12.72 11.27 17 59226 51144 64388345
Pneumoperitoneum 12.67 11.27 14 59229 2697 64436792
Graft versus host disease in eye 12.67 11.27 6 59237 299 64439190
Hepatic cyst infection 12.66 11.27 5 59238 159 64439330
Small intestine gangrene 12.62 11.27 3 59240 15 64439474
Intra-abdominal haemorrhage 12.62 11.27 17 59226 4014 64435475
Orf 12.59 11.27 4 59239 66 64439423
Narrow anterior chamber angle 12.43 11.27 5 59238 167 64439322
Orbital apex syndrome 12.42 11.27 4 59239 69 64439420
Obstructive airways disorder 12.42 11.27 3 59240 23182 64416307
Encephalitis fungal 12.40 11.27 5 59238 168 64439321
Pemphigus 12.40 11.27 23 59220 60678 64378811
Splenorenal shunt 12.31 11.27 3 59240 17 64439472
Mesangioproliferative glomerulonephritis 12.26 11.27 4 59239 72 64439417
Brain compression 12.26 11.27 7 59236 514 64438975
Eczema 12.21 11.27 6 59237 29714 64409775
Rhinovirus infection 12.21 11.27 21 59222 6135 64433354
Abdominal wall abscess 12.17 11.27 9 59234 1027 64438462
Urinary tract infection viral 12.16 11.27 4 59239 74 64439415
Intestinal ulcer perforation 12.16 11.27 3 59240 18 64439471
Anorexia nervosa 12.13 11.27 5 59238 178 64439311
Rectal haemorrhage 12.12 11.27 24 59219 61793 64377696
Nephrotic syndrome 12.10 11.27 27 59216 9540 64429949
Hyperparathyroidism 12.09 11.27 14 59229 2838 64436651
Pneumonia adenoviral 12.08 11.27 5 59238 180 64439309
Pneumonia legionella 12.07 11.27 13 59230 2433 64437056
Influenza like illness 12.06 11.27 24 59219 61678 64377811
Carotid arteriosclerosis 11.97 11.27 12 59231 2067 64437422
Paracoccidioides infection 11.97 11.27 4 59239 78 64439411
Gene mutation 11.95 11.27 12 59231 2070 64437419
Granulomatous dermatitis 11.95 11.27 6 59237 340 64439149
Full blood count decreased 11.94 11.27 3 59240 22579 64416910
Thyroid gland abscess 11.92 11.27 4 59239 79 64439410
Alpha haemolytic streptococcal infection 11.90 11.27 11 59232 1714 64437775
Retinal artery occlusion 11.88 11.27 14 59229 2889 64436600
Sleep disorder 11.87 11.27 23 59220 59686 64379803
Burning sensation 11.84 11.27 17 59226 49647 64389842
Neutrophil Pelger-Huet anomaly present 11.83 11.27 6 59237 347 64439142
Vocal cord thickening 11.78 11.27 4 59239 82 64439407
Pulmonary alveolar haemorrhage 11.78 11.27 27 59216 9711 64429778
Leuconostoc infection 11.76 11.27 3 59240 21 64439468
Overdose 11.75 11.27 92 59151 159474 64280015
Arteritis infective 11.73 11.27 4 59239 83 64439406
Oropharyngeal pain 11.73 11.27 42 59201 88825 64350664
Intentional self-injury 11.73 11.27 6 59237 29038 64410451
Vision blurred 11.71 11.27 43 59200 90273 64349216
White blood cell count increased 11.70 11.27 102 59141 65912 64373577
Septic embolus 11.70 11.27 11 59232 1751 64437738
Vascular anastomotic haemorrhage 11.69 11.27 4 59239 84 64439405
Metastatic malignant melanoma 11.66 11.27 13 59230 2528 64436961
Glomerular filtration rate decreased 11.62 11.27 42 59201 19530 64419959
Encapsulating peritoneal sclerosis 11.61 11.27 8 59235 817 64438672
Toxicity to various agents 11.61 11.27 250 58993 363263 64076226
Perineal cyst 11.60 11.27 4 59239 86 64439403
Therapy change 11.54 11.27 21 59222 6413 64433076
Bronchitis 11.50 11.27 56 59187 108687 64330802
Escherichia bacteraemia 11.47 11.27 19 59224 5384 64434105
Mycobacterium fortuitum infection 11.42 11.27 5 59238 207 64439282
Viral skin infection 11.39 11.27 4 59239 91 64439398
Herpes zoster cutaneous disseminated 11.34 11.27 6 59237 379 64439110
Cutaneous tuberculosis 11.31 11.27 5 59238 212 64439277

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
ATC L04AA06 ANTINEOPLASTIC AND IMMUNOMODULATING AGENTS
IMMUNOSUPPRESSANTS
IMMUNOSUPPRESSANTS
Selective immunosuppressants
MeSH PA D000900 Anti-Bacterial Agents
MeSH PA D000890 Anti-Infective Agents
MeSH PA D000903 Antibiotics, Antineoplastic
MeSH PA D000904 Antibiotics, Antitubercular
MeSH PA D000970 Antineoplastic Agents
MeSH PA D000995 Antitubercular Agents
MeSH PA D004791 Enzyme Inhibitors
FDA EPC N0000175613 Antimetabolite Immunosuppressant
CHEBI has role CHEBI:35705 immunosuppressive agents
CHEBI has role CHEBI:53746 EC 1.1.1.205 inhibitor
CHEBI has role CHEBI:25442 mycotoxins
CHEBI has role CHEBI:33281 antibiotics
CHEBI has role CHEBI:35610 antineoplastic agents
CHEBI has role CHEBI:35703 Xenobiotic
CHEBI has role CHEBI:76964 Penicillium metabolites
CHEBI has role CHEBI:78298 environmental contaminants
CHEBI has role CHEBI:149553 anticoronaviral drug

Drug Use | Suggest Off label Use Form| |View source of the data|

DiseaseRelationSNOMED_IDDOID
Prevention of Liver Transplant Rejection indication
Prevention of Cardiac Transplant Rejection indication
Prevention of Kidney Transplant Rejection indication
Prevention of Lung Transplant Rejection off-label use
Herpes zoster contraindication 4740000 DOID:8536
Progressive multifocal leukoencephalopathy contraindication 22255007 DOID:643
Cytomegalovirus infection contraindication 28944009
Constitutional aplastic anemia contraindication 28975000 DOID:1342
Gastrointestinal ulcer contraindication 40845000
Gastrointestinal perforation contraindication 51875005
Acute nephropathy contraindication 58574008
Acute infectious disease contraindication 63171007
Gastrointestinal hemorrhage contraindication 74474003
Herpes simplex contraindication 88594005 DOID:8566
Malignant lymphoma contraindication 118600007 DOID:0060058
Deficiency of hypoxanthine phosphoribosyltransferase contraindication 124275001
Disease of liver contraindication 235856003 DOID:409
Pregnancy, function contraindication 289908002
Neutropenic disorder contraindication 303011007 DOID:1227
Bone marrow depression contraindication 307762000
Primary malignant neoplasm contraindication 372087000
Malignant neoplasm of skin contraindication 372130007 DOID:4159
Breastfeeding (mother) contraindication 413712001
Opportunistic Fungal Infection contraindication
BK Polyomavirus Reactivation Nephropathy contraindication




๐Ÿถ Veterinary Drug Use

None

๐Ÿถ Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 4.67 acidic
pKa2 11.03 acidic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
Inosine-5'-monophosphate dehydrogenase (IMPDH) Enzyme INHIBITOR IC50 4.70 CHEMBL CHEMBL
Inosine-5'-monophosphate dehydrogenase 1 Enzyme Ki 7.48 CHEMBL
Inosine-5'-monophosphate dehydrogenase 2 Enzyme Ki 8.22 CHEMBL
Inosine-5'-monophosphate dehydrogenase Unclassified IC50 6.92 CHEMBL

External reference:

IDSource
4025608 VUID
N0000176078 NUI
D05095 KEGG_DRUG
4021418 VANDF
4025598 VANDF
4025608 VANDF
C0026933 UMLSCUI
CHEBI:168396 CHEBI
MOA PDB_CHEM_ID
CHEMBL866 ChEMBL_ID
DB01024 DRUGBANK_ID
CHEMBL2106643 ChEMBL_ID
D009173 MESH_DESCRIPTOR_UI
446541 PUBCHEM_CID
6832 IUPHAR_LIGAND_ID
2950 INN_ID
HU9DX48N0T UNII
265323 RXNORM
18132 MMSL
210716 MMSL
d05217 MMSL
005013 NDDF
009984 NDDF
409330005 SNOMEDCT_US
409331009 SNOMEDCT_US
426216009 SNOMEDCT_US
24280-93-1 SECONDARY_CAS_RN

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
Myfortic HUMAN PRESCRIPTION DRUG LABEL 1 0078-0385 TABLET, DELAYED RELEASE 180 mg ORAL NDA 29 sections
Myfortic HUMAN PRESCRIPTION DRUG LABEL 1 0078-0385 TABLET, DELAYED RELEASE 180 mg ORAL NDA 29 sections
Myfortic HUMAN PRESCRIPTION DRUG LABEL 1 0078-0386 TABLET, DELAYED RELEASE 360 mg ORAL NDA 29 sections
Myfortic HUMAN PRESCRIPTION DRUG LABEL 1 0078-0386 TABLET, DELAYED RELEASE 360 mg ORAL NDA 29 sections
Mycophenolic Acid HUMAN PRESCRIPTION DRUG LABEL 1 0378-4201 TABLET, DELAYED RELEASE 180 mg ORAL ANDA 29 sections
Mycophenolic Acid HUMAN PRESCRIPTION DRUG LABEL 1 0378-4202 TABLET, DELAYED RELEASE 360 mg ORAL ANDA 29 sections
Mycophenolic Acid HUMAN PRESCRIPTION DRUG LABEL 1 0904-6785 TABLET, DELAYED RELEASE 180 mg ORAL ANDA 23 sections
Mycophenolic Acid HUMAN PRESCRIPTION DRUG LABEL 1 0904-6785 TABLET, DELAYED RELEASE 180 mg ORAL ANDA 23 sections
Mycophenolic Acid HUMAN PRESCRIPTION DRUG LABEL 1 0904-6786 TABLET, DELAYED RELEASE 360 mg ORAL ANDA 23 sections
Mycophenolic Acid HUMAN PRESCRIPTION DRUG LABEL 1 0904-6786 TABLET, DELAYED RELEASE 360 mg ORAL ANDA 23 sections
Mycophenolic Acid HUMAN PRESCRIPTION DRUG LABEL 1 16729-189 TABLET, DELAYED RELEASE 360 mg ORAL ANDA 27 sections
Mycophenolic Acid HUMAN PRESCRIPTION DRUG LABEL 1 16729-261 TABLET, DELAYED RELEASE 180 mg ORAL ANDA 27 sections
mycophenolic acid HUMAN PRESCRIPTION DRUG LABEL 1 24979-160 TABLET, DELAYED RELEASE 180 mg ORAL ANDA 29 sections
mycophenolic acid HUMAN PRESCRIPTION DRUG LABEL 1 24979-161 TABLET, DELAYED RELEASE 360 mg ORAL ANDA 29 sections
Mycophenolic Acid HUMAN PRESCRIPTION DRUG LABEL 1 50268-559 TABLET, DELAYED RELEASE 180 mg ORAL ANDA 23 sections
Mycophenolic Acid HUMAN PRESCRIPTION DRUG LABEL 1 50268-560 TABLET, DELAYED RELEASE 360 mg ORAL ANDA 23 sections
Mycophenolic Acid HUMAN PRESCRIPTION DRUG LABEL 1 51079-508 TABLET, DELAYED RELEASE 180 mg ORAL ANDA 29 sections
Mycophenolic Acid HUMAN PRESCRIPTION DRUG LABEL 1 51079-509 TABLET, DELAYED RELEASE 360 mg ORAL ANDA 29 sections
Mycophenolic Acid HUMAN PRESCRIPTION DRUG LABEL 1 60429-016 TABLET, DELAYED RELEASE 180 mg ORAL ANDA 23 sections
Mycophenolic Acid HUMAN PRESCRIPTION DRUG LABEL 1 60429-017 TABLET, DELAYED RELEASE 360 mg ORAL ANDA 23 sections
Mycophenolic Acid HUMAN PRESCRIPTION DRUG LABEL 1 60505-2965 TABLET, DELAYED RELEASE 180 mg ORAL ANDA 23 sections
Mycophenolic Acid HUMAN PRESCRIPTION DRUG LABEL 1 60505-2965 TABLET, DELAYED RELEASE 180 mg ORAL ANDA 23 sections
Mycophenolic Acid HUMAN PRESCRIPTION DRUG LABEL 1 60505-2966 TABLET, DELAYED RELEASE 360 mg ORAL ANDA 23 sections
Mycophenolic Acid HUMAN PRESCRIPTION DRUG LABEL 1 60505-2966 TABLET, DELAYED RELEASE 360 mg ORAL ANDA 23 sections
MYCOPHENOLIC ACID Human Prescription Drug Label 1 67877-426 TABLET, DELAYED RELEASE 180 mg ORAL ANDA 28 sections
MYCOPHENOLIC ACID Human Prescription Drug Label 1 67877-427 TABLET, DELAYED RELEASE 360 mg ORAL ANDA 28 sections
Mycophenolic Acid HUMAN PRESCRIPTION DRUG LABEL 1 68084-907 TABLET, DELAYED RELEASE 180 mg ORAL ANDA 26 sections
Mycophenolic Acid HUMAN PRESCRIPTION DRUG LABEL 1 68084-918 TABLET, DELAYED RELEASE 360 mg ORAL ANDA 26 sections
mycophenolic acid HUMAN PRESCRIPTION DRUG LABEL 1 68254-5001 TABLET, DELAYED RELEASE 180 mg ORAL ANDA 26 sections
mycophenolic acid HUMAN PRESCRIPTION DRUG LABEL 1 68254-5002 TABLET, DELAYED RELEASE 360 mg ORAL ANDA 26 sections