mycophenolic acid Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
1860 37415-62-6

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • mycophenolate
  • mycophenolic acid
  • mycophenolate sodium
  • mycophenolic acid monosodium salt
  • sodium mycophenolate
Compound derived from Penicillium stoloniferum and related species. It blocks de novo biosynthesis of purine nucleotides by inhibition of the enzyme inosine monophosphate dehydrogenase (IMP DEHYDROGENASE). Mycophenolic acid exerts selective effects on the immune system in which it prevents the proliferation of T-CELLS, LYMPHOCYTES, and the formation of antibodies from B-CELLS. It may also inhibit recruitment of LEUKOCYTES to sites of INFLAMMATION.
  • Molecular weight: 320.34
  • Formula: C17H20O6
  • CLOGP: 2.29
  • LIPINSKI: 0
  • HAC: 6
  • HDO: 2
  • TPSA: 93.06
  • ALOGS: -3.96
  • ROTB: 6

  • Status: OFP

  • Legend:
    OFP - off patent
    OFM - off market
    ONP - on patent

Drug dosage:

DoseUnitRoute
2 g O
2 g P

ADMET properties:

PropertyValueReference
BDDCS (Biopharmaceutical Drug Disposition Classification System) 2 Benet LZ, Broccatelli F, Oprea TI
EoM (Fraction excreted unchanged in urine) 0.50 % Benet LZ, Broccatelli F, Oprea TI
MRTD (Maximum Recommended Therapeutic Daily Dose) 64.22 ┬ÁM/kg/day Contrera JF, Matthews EJ, Kruhlak NL, Benz RD
Vd (Volume of distribution) 0.77 L/kg Lombardo F, Berellini G, Obach RS
CL (Clearance) 2.33 mL/min/kg Lombardo F, Berellini G, Obach RS
fu (Fraction unbound in plasma) 0.02 % Lombardo F, Berellini G, Obach RS
t_half (Half-life) 9.70 hours Lombardo F, Berellini G, Obach RS

Approvals:

DateAgencyCompanyOrphan
Feb. 27, 2004 FDA NOVARTIS

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Cytomegalovirus infection 663.43 12.22 283 26506 17861 46641412
Transplant rejection 488.96 12.22 190 26599 9406 46649867
Kidney transplant rejection 405.73 12.22 133 26656 3985 46655288
Post transplant lymphoproliferative disorder 314.32 12.22 108 26681 3748 46655525
Complications of transplanted kidney 292.92 12.22 90 26699 2173 46657100
Thrombotic microangiopathy 246.56 12.22 112 26677 8194 46651079
Polyomavirus-associated nephropathy 230.52 12.22 68 26721 1422 46657851
Product use in unapproved indication 196.06 12.22 250 26539 90023 46569250
BK virus infection 190.96 12.22 69 26720 2780 46656493
Cytomegalovirus viraemia 177.33 12.22 74 26715 4404 46654869
COVID-19 176.58 12.22 118 26671 18457 46640816
Epstein-Barr virus infection 168.87 12.22 81 26708 6703 46652570
Posterior reversible encephalopathy syndrome 165.52 12.22 105 26684 15036 46644237
Leukopenia 155.83 12.22 194 26595 68149 46591124
Immunosuppressant drug level increased 153.10 12.22 61 26728 3221 46656052
Delayed graft function 131.29 12.22 40 26749 937 46658336
Kidney fibrosis 128.24 12.22 43 26746 1382 46657891
Chronic allograft nephropathy 123.93 12.22 35 26754 623 46658650
Off label use 119.81 12.22 482 26307 379359 46279914
Pneumocystis jirovecii pneumonia 112.59 12.22 83 26706 15165 46644108
Blood creatinine increased 108.64 12.22 173 26616 76230 46583043
Renal impairment 91.74 12.22 158 26631 74214 46585059
West Nile viral infection 88.13 12.22 24 26765 371 46658902
Varicella zoster virus infection 87.02 12.22 37 26752 2306 46656967
Lymphocele 82.25 12.22 27 26762 811 46658462
Tubulointerstitial nephritis 82.07 12.22 68 26721 14720 46644553
Aspergillus infection 80.86 12.22 50 26739 6840 46652433
Renal transplant failure 80.17 12.22 25 26764 634 46658639
Nephropathy toxic 79.72 12.22 51 26738 7403 46651870
Multiple organ dysfunction syndrome 78.91 12.22 121 26668 51589 46607684
Epstein-Barr viraemia 77.42 12.22 25 26764 712 46658561
Post transplant distal limb syndrome 76.75 12.22 19 26770 197 46659076
Histoplasmosis disseminated 74.53 12.22 27 26762 1095 46658178
Escherichia infection 73.44 12.22 56 26733 10761 46648512
Apoptosis 71.16 12.22 15 26774 69 46659204
Graft versus host disease in skin 70.48 12.22 32 26757 2335 46656938
Graft loss 70.24 12.22 20 26769 367 46658906
Human herpesvirus 6 infection 69.56 12.22 32 26757 2407 46656866
Graft versus host disease in gastrointestinal tract 68.20 12.22 32 26757 2518 46656755
Graft versus host disease 67.80 12.22 44 26745 6544 46652729
Transplant dysfunction 65.38 12.22 38 26751 4644 46654629
Trichodysplasia spinulosa 63.83 12.22 19 26770 410 46658863
Liver transplant rejection 62.06 12.22 25 26764 1358 46657915
Central nervous system lymphoma 57.42 12.22 23 26766 1231 46658042
Polyomavirus viraemia 56.72 12.22 17 26772 376 46658897
Adenovirus infection 56.23 12.22 29 26760 2801 46656472
Klebsiella infection 55.43 12.22 39 26750 6623 46652650
Ureaplasma infection 54.04 12.22 17 26772 444 46658829
Respiratory failure 53.68 12.22 147 26642 94669 46564604
Renal transplant 53.12 12.22 22 26767 1283 46657990
Fall 51.66 12.22 68 26721 329029 46330244
Renal tubular atrophy 51.65 12.22 17 26772 515 46658758
Drug hypersensitivity 51.28 12.22 39 26750 243786 46415487
Fatigue 50.49 12.22 180 26609 608517 46050756
Parvovirus B19 infection 50.12 12.22 15 26774 330 46658943
Blastomycosis 49.58 12.22 14 26775 249 46659024
Acute kidney injury 48.05 12.22 264 26525 235591 46423682
JC virus infection 48.01 12.22 22 26767 1640 46657633
Pancreas transplant rejection 47.74 12.22 12 26777 133 46659140
Human ehrlichiosis 47.73 12.22 13 26776 201 46659072
Viraemia 47.46 12.22 19 26770 1015 46658258
Cryptococcosis 47.40 12.22 18 26771 834 46658439
Cytomegalovirus colitis 47.11 12.22 22 26767 1713 46657560
Bronchopulmonary aspergillosis 46.95 12.22 37 26752 7459 46651814
Diffuse large B-cell lymphoma 43.10 12.22 32 26757 5906 46653367
Focal segmental glomerulosclerosis 41.64 12.22 19 26770 1402 46657871
Pain 40.85 12.22 139 26650 476809 46182464
Disseminated mucormycosis 39.45 12.22 10 26779 115 46659158
Haemolytic uraemic syndrome 39.39 12.22 22 26767 2492 46656781
Diabetes mellitus 39.31 12.22 88 26701 49977 46609296
Encephalitis viral 39.16 12.22 19 26770 1611 46657662
Immunosuppressant drug level decreased 38.92 12.22 16 26773 916 46658357
Histoplasmosis 38.50 12.22 19 26770 1671 46657602
Alveolar proteinosis 38.27 12.22 12 26777 310 46658963
Drug level increased 38.26 12.22 50 26739 18391 46640882
Biopsy lung abnormal 37.84 12.22 10 26779 137 46659136
Pyrexia 37.52 12.22 334 26455 348468 46310805
Phaeohyphomycosis 37.24 12.22 11 26778 231 46659042
Atypical haemolytic uraemic syndrome 37.18 12.22 13 26776 475 46658798
Nocardiosis 36.31 12.22 18 26771 1599 46657674
Renal tubular necrosis 35.45 12.22 37 26752 10722 46648551
Rheumatoid arthritis 35.29 12.22 52 26737 240163 46419110
Injection site pain 35.24 12.22 9 26780 107143 46552130
Human polyomavirus infection 33.90 12.22 10 26779 209 46659064
Toxoplasmosis 32.74 12.22 16 26773 1378 46657895
Aplasia pure red cell 32.46 12.22 24 26765 4401 46654872
Enterococcal infection 32.40 12.22 29 26760 6958 46652315
Arthropathy 32.27 12.22 5 26784 84695 46574578
Injection site erythema 31.77 12.22 3 26786 74424 46584849
Rhodococcus infection 31.64 12.22 8 26781 91 46659182
Hepatitis E 31.45 12.22 15 26774 1224 46658049
Diarrhoea 31.36 12.22 472 26317 559130 46100143
Arthralgia 31.34 12.22 106 26683 364497 46294776
Dizziness 31.32 12.22 96 26693 340318 46318955
Depression 31.14 12.22 31 26758 170073 46489200
Interstitial lung disease 30.86 12.22 84 26705 53865 46605408
Malacoplakia vesicae 30.48 12.22 7 26782 51 46659222
Rash 30.40 12.22 104 26685 356408 46302865
Human herpesvirus 6 encephalitis 30.11 12.22 8 26781 112 46659161
Cystitis haemorrhagic 30.05 12.22 21 26768 3526 46655747
Proteinuria 29.95 12.22 42 26747 16511 46642762
Acute graft versus host disease 29.88 12.22 22 26767 4008 46655265
Acute graft versus host disease in intestine 29.78 12.22 16 26773 1679 46657594
Biloma 29.47 12.22 7 26782 60 46659213
Malacoplakia gastrointestinal 29.17 12.22 7 26782 63 46659210
Haemolytic anaemia 29.17 12.22 32 26757 9810 46649463
Psoriasis 29.14 12.22 5 26784 78599 46580674
Obliterative bronchiolitis 29.09 12.22 16 26773 1759 46657514
Microsporidia infection 28.65 12.22 9 26780 234 46659039
Gastroenteritis norovirus 28.06 12.22 15 26774 1558 46657715
Escherichia urinary tract infection 27.91 12.22 32 26757 10291 46648982
Donor specific antibody present 27.57 12.22 6 26783 33 46659240
Progressive multifocal leukoencephalopathy 27.09 12.22 33 26756 11313 46647960
Disseminated mycobacterium avium complex infection 26.46 12.22 6 26783 41 46659232
End stage renal disease 26.45 12.22 24 26765 5862 46653411
Anxiety 26.11 12.22 40 26749 181917 46477356
Graft complication 26.03 12.22 8 26781 193 46659080
Hydronephrosis 25.70 12.22 28 26761 8517 46650756
Mycobacterium avium complex infection 25.58 12.22 17 26772 2631 46656642
Bacterial pyelonephritis 25.48 12.22 9 26780 339 46658934
Constipation 25.24 12.22 38 26751 174059 46485214
Cytomegalovirus nephritis 24.92 12.22 5 26784 17 46659256
Hyperammonaemia 24.74 12.22 21 26768 4695 46654578
Anogenital warts 24.52 12.22 9 26780 379 46658894
Malignant neoplasm progression 24.35 12.22 4 26785 64922 46594351
Incision site pain 24.32 12.22 12 26777 1055 46658218
Pseudomonas infection 24.31 12.22 29 26760 9729 46649544
Herpes simplex oesophagitis 24.21 12.22 7 26782 136 46659137
Disseminated varicella zoster vaccine virus infection 24.17 12.22 6 26783 63 46659210
Brain abscess 24.16 12.22 14 26775 1701 46657572
Hypogammaglobulinaemia 24.10 12.22 22 26767 5416 46653857
Perinephric abscess 23.79 12.22 7 26782 145 46659128
Urinary fistula 23.72 12.22 5 26784 23 46659250
Acute respiratory distress syndrome 23.69 12.22 44 26745 21878 46637395
Pyelonephritis 23.49 12.22 36 26753 15321 46643952
Coccidioidomycosis 23.36 12.22 11 26778 872 46658401
Pruritus 23.24 12.22 67 26722 242285 46416988
Necrotising herpetic retinopathy 23.21 12.22 6 26783 75 46659198
Lupus nephritis 23.11 12.22 15 26774 2231 46657042
Renal failure 22.96 12.22 127 26662 113467 46545806
Insomnia 22.95 12.22 37 26752 164887 46494386
Pyelonephritis acute 22.91 12.22 19 26770 4115 46655158
Herpes simplex hepatitis 22.83 12.22 8 26781 294 46658979
Haemophagocytic lymphohistiocytosis 22.79 12.22 26 26763 8316 46650957
Polyomavirus test positive 22.45 12.22 6 26783 86 46659187
Cytomegalovirus hepatitis 22.23 12.22 8 26781 318 46658955
Mycobacterial infection 22.13 12.22 13 26776 1620 46657653
Agranulocytosis 22.09 12.22 43 26746 22142 46637131
Lung transplant 21.92 12.22 16 26773 2876 46656397
Hospitalisation 21.89 12.22 83 26706 63302 46595971
Papilloma viral infection 21.61 12.22 12 26777 1344 46657929
Tuberculosis gastrointestinal 21.42 12.22 8 26781 354 46658919
Hypoaesthesia 21.36 12.22 22 26767 118847 46540426
Disseminated cytomegaloviral infection 21.34 12.22 6 26783 105 46659168
Infection reactivation 21.31 12.22 10 26779 787 46658486
Cytomegalovirus syndrome 21.18 12.22 6 26783 108 46659165
Back pain 20.92 12.22 57 26732 209982 46449291
Mucinous adenocarcinoma of appendix 20.85 12.22 4 26785 10 46659263
Lymphopenia 20.84 12.22 34 26755 15259 46644014
Liver abscess 20.81 12.22 15 26774 2644 46656629
Escherichia pyelonephritis 20.80 12.22 8 26781 384 46658889
Osteoarthritis 20.80 12.22 5 26784 62020 46597253
Urinoma 20.73 12.22 5 26784 46 46659227
Complications of transplanted lung 20.67 12.22 7 26782 232 46659041
Pneumopericardium 20.54 12.22 5 26784 48 46659225
Systemic candida 20.47 12.22 15 26774 2712 46656561
Cytomegalovirus chorioretinitis 20.43 12.22 12 26777 1495 46657778
Mucormycosis 20.43 12.22 14 26775 2278 46656995
Pain in extremity 20.34 12.22 78 26711 258602 46400671
Intentional overdose 20.33 12.22 6 26783 64938 46594335
Systemic bacterial infection 20.32 12.22 4 26785 12 46659261
Dermatitis papillaris capillitii 20.32 12.22 4 26785 12 46659261
Urinary tract infection 20.17 12.22 204 26585 220062 46439211
Septic shock 20.15 12.22 76 26713 57817 46601456
Pyelonephritis fungal 20.13 12.22 6 26783 130 46659143
Nephrotic syndrome 20.05 12.22 19 26770 4902 46654371
Suicidal ideation 20.01 12.22 4 26785 56378 46602895
Diabetic macroangiopathy 19.88 12.22 6 26783 136 46659137
Chronic kidney disease 19.84 12.22 60 26729 40811 46618462
Transplant failure 19.72 12.22 11 26778 1243 46658030
Mycobacterium chelonae infection 19.71 12.22 8 26781 443 46658830
Ureteral necrosis 19.68 12.22 5 26784 58 46659215
American trypanosomiasis 19.45 12.22 5 26784 61 46659212
Epstein-Barr virus associated lymphoma 19.30 12.22 7 26782 285 46658988
Disseminated cryptococcosis 19.27 12.22 7 26782 286 46658987
Heart transplant rejection 19.16 12.22 8 26781 476 46658797
Acute motor axonal neuropathy 19.05 12.22 4 26785 18 46659255
Drug level decreased 18.88 12.22 20 26769 5892 46653381
Red blood cells urine positive 18.81 12.22 14 26775 2593 46656680
Concomitant disease progression 18.79 12.22 13 26776 2149 46657124
Cat scratch disease 18.78 12.22 6 26783 165 46659108
Gastrointestinal mucormycosis 18.78 12.22 6 26783 165 46659108
Rhinovirus infection 18.69 12.22 16 26773 3620 46655653
Lung transplant rejection 18.58 12.22 9 26780 760 46658513
Emphysematous pyelonephritis 18.44 12.22 6 26783 175 46659098
Urinary tract candidiasis 18.39 12.22 8 26781 527 46658746
Balance disorder 18.38 12.22 7 26782 64514 46594759
Bacillary angiomatosis 18.32 12.22 5 26784 78 46659195
Chronic graft versus host disease 18.26 12.22 14 26775 2711 46656562
Joint swelling 18.13 12.22 43 26746 166030 46493243
Smooth muscle cell neoplasm 18.00 12.22 8 26781 555 46658718
Human herpesvirus 8 infection 17.89 12.22 6 26783 193 46659080
Malacoplakia 17.86 12.22 5 26784 86 46659187
Renal lymphocele 17.81 12.22 5 26784 87 46659186
Pulmonary mucormycosis 17.55 12.22 5 26784 92 46659181
Intentional product use issue 17.31 12.22 68 26721 52712 46606561
Neutrophil count increased 17.18 12.22 30 26759 14223 46645050
Sepsis 17.08 12.22 135 26654 135879 46523394
Purulent pericarditis 16.87 12.22 4 26785 34 46659239
Pulmonary alveolar haemorrhage 16.82 12.22 16 26773 4146 46655127
Encephalitis 16.71 12.22 21 26768 7427 46651846
Joint tuberculosis 16.54 12.22 5 26784 114 46659159
Myocardial infarction 16.46 12.22 19 26770 97509 46561764
Pancytopenia 16.46 12.22 94 26695 84964 46574309
Colitis 16.44 12.22 53 26736 37294 46621979
Biopsy kidney 16.33 12.22 5 26784 119 46659154
Cardiac murmur functional 16.29 12.22 4 26785 40 46659233
Graft versus host disease in liver 16.24 12.22 7 26782 451 46658822
Orbital apex syndrome 16.20 12.22 4 26785 41 46659232
Acid base balance abnormal 16.10 12.22 6 26783 264 46659009
Chronic kidney disease-mineral and bone disorder 16.10 12.22 6 26783 264 46659009
Bacteraemia 16.00 12.22 29 26760 14150 46645123
Disseminated tuberculosis 15.99 12.22 13 26776 2739 46656534
Plasmapheresis 15.97 12.22 6 26783 270 46659003
Nephrostomy 15.94 12.22 4 26785 44 46659229
Somnolence 15.93 12.22 42 26747 156479 46502794
Contusion 15.93 12.22 16 26773 87471 46571802
Bronchiectasis 15.91 12.22 23 26766 9293 46649980
Cytomegalovirus gastrointestinal infection 15.78 12.22 6 26783 279 46658994
Acanthamoeba infection 15.78 12.22 4 26785 46 46659227
Necrotising retinitis 15.62 12.22 6 26783 287 46658986
Pancreatitis necrotising 15.58 12.22 10 26779 1459 46657814
Epstein-Barr virus associated lymphoproliferative disorder 15.52 12.22 10 26779 1469 46657804
Encephalitis cytomegalovirus 15.36 12.22 7 26782 515 46658758
Cardiac failure congestive 15.35 12.22 18 26771 91732 46567541
Brain natriuretic peptide increased 15.33 12.22 16 26773 4634 46654639
Scedosporium infection 15.31 12.22 7 26782 519 46658754
Drug resistance 15.31 12.22 32 26757 17336 46641937
Asthma 15.27 12.22 18 26771 91524 46567749
Meningitis histoplasma 15.24 12.22 3 26786 9 46659264
Chronic obstructive pulmonary disease 15.21 12.22 7 26782 57626 46601647
Pneumonia cytomegaloviral 15.21 12.22 11 26778 1949 46657324
Fungal sepsis 15.20 12.22 9 26780 1138 46658135
Influenza like illness 15.19 12.22 7 26782 57563 46601710
Fungaemia 15.06 12.22 11 26778 1980 46657293
Dermatomyositis 14.91 12.22 11 26778 2010 46657263
Graft versus host disease in lung 14.86 12.22 6 26783 328 46658945
Mucocutaneous leishmaniasis 14.80 12.22 6 26783 331 46658942
Hypersensitivity 14.80 12.22 41 26748 150280 46508993
Strongyloidiasis 14.74 12.22 8 26781 857 46658416
Bacterial colitis 14.68 12.22 4 26785 62 46659211
Organising pneumonia 14.63 12.22 16 26773 4886 46654387
Nosocomial infection 14.60 12.22 10 26779 1625 46657648
Graft versus host disease in eye 14.56 12.22 4 26785 64 46659209
Anorexia nervosa 14.40 12.22 5 26784 179 46659094
Urosepsis 14.37 12.22 29 26760 15324 46643949
Hyperamylasaemia 14.26 12.22 6 26783 364 46658909
Reversible cerebral vasoconstriction syndrome 14.16 12.22 10 26779 1707 46657566
Lymphoproliferative disorder 14.15 12.22 12 26777 2680 46656593
Mycobacterium abscessus infection 14.15 12.22 7 26782 619 46658654
Contraindicated product administered 14.12 12.22 15 26774 79932 46579341
Herpes simplex 14.08 12.22 19 26770 7204 46652069
Aphthous ulcer 14.07 12.22 22 26767 9526 46649747
Protein urine present 14.03 12.22 16 26773 5115 46654158
Gastroenteritis cryptosporidial 13.97 12.22 4 26785 75 46659198
B-cell lymphoma 13.96 12.22 13 26776 3281 46655992
Asthenia 13.92 12.22 113 26676 310962 46348311
Transplant 13.83 12.22 7 26782 650 46658623
Renal disorder 13.73 12.22 40 26749 26646 46632627
Superinfection bacterial 13.73 12.22 6 26783 400 46658873
Anuria 13.70 12.22 24 26765 11407 46647866
Histoplasmosis cutaneous 13.43 12.22 3 26786 19 46659254
Mycoplasma infection 13.41 12.22 6 26783 423 46658850
Hyperuricaemia 13.39 12.22 15 26774 4702 46654571
Bacteroides bacteraemia 13.17 12.22 3 26786 21 46659252
Urinary tract infection bacterial 13.14 12.22 14 26775 4151 46655122
Pneumonia 13.09 12.22 295 26494 376025 46283248
Bacterial sepsis 13.08 12.22 13 26776 3554 46655719
Neuroendocrine carcinoma of the skin 13.08 12.22 6 26783 448 46658825
Angiosarcoma 12.84 12.22 5 26784 248 46659025
Therapy cessation 12.83 12.22 39 26750 26590 46632683
Sterile pyuria 12.81 12.22 3 26786 24 46659249
Typhoid fever 12.81 12.22 3 26786 24 46659249
Bone marrow granuloma 12.81 12.22 3 26786 24 46659249
Neutropenia 12.79 12.22 132 26657 143072 46516201
Normocytic anaemia 12.69 12.22 8 26781 1131 46658142
Suicide attempt 12.61 12.22 8 26781 55028 46604245
Genital herpes 12.57 12.22 9 26780 1570 46657703
Renal haemorrhage 12.48 12.22 7 26782 799 46658474
Necrotising fasciitis 12.39 12.22 11 26778 2612 46656661
Femur fracture 12.37 12.22 3 26786 36994 46622279
Extremity necrosis 12.30 12.22 9 26780 1624 46657649
Epstein-Barr virus antibody positive 12.25 12.22 5 26784 281 46658992

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Kidney transplant rejection 680.90 13.10 269 32229 7240 29912740
Cytomegalovirus infection 521.79 13.10 323 32175 23351 29896629
Transplant rejection 486.50 13.10 225 32273 8981 29910999
Complications of transplanted kidney 425.19 13.10 162 32336 3939 29916041
COVID-19 353.91 13.10 228 32270 17650 29902330
Polyomavirus-associated nephropathy 312.92 13.10 121 32377 3064 29916916
BK virus infection 234.63 13.10 108 32390 4256 29915724
Immunosuppressant drug level increased 230.00 13.10 109 32389 4593 29915387
Transplant dysfunction 229.78 13.10 89 32409 2263 29917717
Post transplant lymphoproliferative disorder 220.43 13.10 110 32388 5196 29914784
Blood creatinine increased 204.44 13.10 360 32138 91015 29828965
Hepatitis E 185.57 13.10 69 32429 1563 29918417
Renal transplant failure 178.98 13.10 60 32438 991 29918989
Product use in unapproved indication 161.69 13.10 288 32210 73405 29846575
Thrombotic microangiopathy 153.70 13.10 103 32395 8507 29911473
JC virus infection 151.27 13.10 61 32437 1729 29918251
Nephropathy toxic 138.50 13.10 105 32393 10534 29909446
West Nile viral infection 129.47 13.10 41 32457 560 29919420
Transplant failure 122.30 13.10 58 32440 2446 29917534
Cytomegalovirus viraemia 120.57 13.10 76 32422 5653 29914327
Aspergillus infection 120.30 13.10 95 32403 10119 29909861
Leukopenia 118.66 13.10 216 32282 55943 29864037
Delayed graft function 115.50 13.10 50 32448 1699 29918281
Incision site pain 115.29 13.10 52 32446 1952 29918028
Epstein-Barr virus infection 114.38 13.10 78 32420 6628 29913352
Mucormycosis 108.65 13.10 69 32429 5199 29914781
Renal tubular atrophy 106.62 13.10 41 32457 1021 29918959
Kidney fibrosis 104.00 13.10 49 32449 2036 29917944
Drug level increased 96.33 13.10 109 32389 18245 29901735
Cryptococcosis 94.99 13.10 44 32454 1758 29918222
Chronic allograft nephropathy 89.19 13.10 37 32461 1129 29918851
Phaeohyphomycosis 87.23 13.10 33 32465 785 29919195
Lymphocyte count decreased 86.42 13.10 105 32393 18950 29901030
Nocardiosis 85.92 13.10 51 32447 3404 29916576
Proteinuria 83.23 13.10 95 32403 16050 29903930
Apoptosis 82.73 13.10 23 32475 193 29919787
Bronchopulmonary aspergillosis 80.38 13.10 82 32416 12202 29907778
Strongyloidiasis 78.31 13.10 42 32456 2304 29917676
Fall 77.65 13.10 51 32447 181821 29738159
Klebsiella infection 76.71 13.10 62 32436 6825 29913155
Histoplasmosis 73.30 13.10 33 32465 1233 29918747
COVID-19 pneumonia 70.83 13.10 50 32448 4490 29915490
Cystitis haemorrhagic 70.73 13.10 51 32447 4736 29915244
Off label use 70.01 13.10 486 32012 248804 29671176
Focal segmental glomerulosclerosis 67.49 13.10 35 32463 1792 29918188
Blastomycosis 67.26 13.10 21 32477 273 29919707
Liver transplant rejection 66.85 13.10 37 32461 2161 29917819
Lymphocele 65.78 13.10 32 32466 1428 29918552
Fatigue 65.76 13.10 158 32340 320515 29599465
Pneumonia cryptococcal 65.71 13.10 26 32472 700 29919280
Rash 65.54 13.10 67 32431 191822 29728158
Graft loss 64.50 13.10 27 32471 843 29919137
Acute kidney injury 64.47 13.10 512 31986 273330 29646650
Progressive multifocal leukoencephalopathy 64.19 13.10 63 32435 8950 29911030
Red blood cells urine positive 62.68 13.10 32 32466 1585 29918395
Encephalitis viral 62.31 13.10 29 32469 1171 29918809
Enterococcal infection 61.41 13.10 59 32439 8165 29911815
Parvovirus B19 infection 60.80 13.10 23 32475 547 29919433
Posterior reversible encephalopathy syndrome 58.56 13.10 59 32439 8648 29911332
Graft versus host disease in skin 57.66 13.10 39 32459 3268 29916712
Acinetobacter infection 57.44 13.10 26 32472 984 29918996
Urinary tract infection 57.28 13.10 193 32305 73466 29846514
Diabetes mellitus 56.51 13.10 134 32364 41731 29878249
Cytomegalovirus colitis 56.25 13.10 34 32464 2345 29917635
Scedosporium infection 55.74 13.10 23 32475 692 29919288
Adenovirus infection 55.26 13.10 42 32456 4226 29915754
Malacoplakia 55.03 13.10 15 32483 116 29919864
Neutrophil count increased 54.67 13.10 75 32423 15248 29904732
Pseudomonas infection 54.56 13.10 62 32436 10420 29909560
Dizziness 53.01 13.10 81 32417 194828 29725152
Graft versus host disease 52.77 13.10 60 32438 10090 29909890
Renal impairment 52.27 13.10 205 32293 83979 29836001
Graft versus host disease in lung 52.23 13.10 20 32478 492 29919488
Renal tubular necrosis 51.95 13.10 73 32425 15178 29904802
Septic shock 51.53 13.10 169 32329 63438 29856542
Disseminated cryptococcosis 51.20 13.10 24 32474 985 29918995
Graft versus host disease in gastrointestinal tract 50.68 13.10 35 32463 3034 29916946
Hydronephrosis 49.95 13.10 55 32443 8928 29911052
Ureteric stenosis 49.58 13.10 25 32473 1206 29918774
Protein urine present 49.01 13.10 41 32457 4734 29915246
Pneumonia cytomegaloviral 48.81 13.10 33 32465 2763 29917217
Renal artery stenosis 47.97 13.10 28 32470 1811 29918169
Pruritus 46.64 13.10 36 32462 118168 29801812
Depression 46.41 13.10 20 32478 90417 29829563
Infection reactivation 46.33 13.10 22 32476 930 29919050
Acanthamoeba infection 46.04 13.10 18 32480 469 29919511
Malignant neoplasm progression 45.89 13.10 11 32487 72276 29847704
Pulmonary nocardiosis 45.84 13.10 17 32481 382 29919598
Pneumocystis jirovecii pneumonia 45.53 13.10 73 32425 17047 29902933
Pain 44.79 13.10 74 32424 172567 29747413
Alternaria infection 41.98 13.10 15 32483 302 29919678
Acute graft versus host disease 41.77 13.10 41 32457 5823 29914157
Polyomavirus viraemia 41.72 13.10 17 32481 495 29919485
Blood urea increased 40.78 13.10 99 32399 31282 29888698
Escherichia infection 40.53 13.10 42 32456 6363 29913617
Anxiety 39.95 13.10 24 32474 89847 29830133
Chronic graft versus host disease in skin 39.26 13.10 18 32480 702 29919278
Histology abnormal 38.99 13.10 14 32484 286 29919694
Trichodysplasia spinulosa 38.81 13.10 13 32485 214 29919766
Brain abscess 38.32 13.10 28 32470 2653 29917327
Chronic graft versus host disease 37.46 13.10 33 32465 4086 29915894
Pancreas transplant rejection 37.36 13.10 12 32486 172 29919808
Cryptosporidiosis infection 37.12 13.10 14 32484 330 29919650
Mycobacterial infection 36.63 13.10 23 32475 1698 29918282
Chronic graft versus host disease in liver 36.23 13.10 13 32485 265 29919715
Acute respiratory distress syndrome 35.95 13.10 79 32419 23393 29896587
Coronavirus infection 35.83 13.10 30 32468 3468 29916512
Renal transplant 35.82 13.10 23 32475 1765 29918215
Pyelonephritis acute 35.70 13.10 22 32476 1571 29918409
Constipation 35.64 13.10 42 32456 112864 29807116
Urinoma 35.20 13.10 12 32486 209 29919771
Smooth muscle cell neoplasm 34.96 13.10 10 32488 94 29919886
Syncope 34.58 13.10 25 32473 84878 29835102
Graft versus host disease in liver 33.61 13.10 18 32480 984 29918996
Viraemia 33.55 13.10 19 32479 1160 29918820
Pyelonephritis 33.29 13.10 35 32463 5391 29914589
Basal cell carcinoma 32.86 13.10 61 32437 16007 29903973
Gastroenteritis norovirus 32.66 13.10 20 32478 1412 29918568
Hyperhidrosis 32.60 13.10 16 32482 67074 29852906
Myocardial infarction 32.41 13.10 54 32444 125571 29794409
Drug hypersensitivity 32.31 13.10 17 32481 68502 29851478
Varicella zoster virus infection 32.26 13.10 19 32479 1249 29918731
Squamous cell carcinoma 31.88 13.10 47 32451 10203 29909777
American trypanosomiasis 31.83 13.10 11 32487 200 29919780
Escherichia urinary tract infection 31.81 13.10 26 32472 2906 29917074
Somnolence 31.62 13.10 35 32463 96728 29823252
Dyspnoea 31.61 13.10 222 32276 333073 29586907
Chronic obstructive pulmonary disease 31.35 13.10 6 32492 46120 29873860
Arthralgia 30.92 13.10 63 32435 135728 29784252
Lymphopenia 30.80 13.10 53 32445 13110 29906870
Haemophagocytic lymphohistiocytosis 30.61 13.10 45 32453 9746 29910234
Donor specific antibody present 30.53 13.10 9 32489 95 29919885
Pneumonia escherichia 29.66 13.10 12 32486 343 29919637
Rhodococcus infection 29.50 13.10 10 32488 171 29919809
Papilloma viral infection 28.96 13.10 12 32486 365 29919615
Meningoencephalitis amoebic 28.41 13.10 9 32489 123 29919857
Decreased appetite 28.18 13.10 77 32421 149833 29770147
Trichophytosis 27.84 13.10 11 32487 295 29919685
Ventricular remodelling 27.80 13.10 8 32490 77 29919903
Necrotising oesophagitis 27.60 13.10 12 32486 412 29919568
Immune reconstitution inflammatory syndrome 27.26 13.10 41 32457 9060 29910920
Immunosuppressant drug level decreased 27.23 13.10 17 32481 1242 29918738
Cardiac failure congestive 27.06 13.10 31 32467 84376 29835604
Human herpesvirus 6 infection 26.97 13.10 20 32478 1938 29918042
Dermatophytosis 26.95 13.10 10 32488 225 29919755
Diarrhoea 26.95 13.10 510 31988 333593 29586387
Epstein-Barr virus associated lymphoproliferative disorder 26.88 13.10 19 32479 1709 29918271
Meningitis cryptococcal 26.38 13.10 20 32478 2004 29917976
Cerebral aspergillosis 26.05 13.10 17 32481 1341 29918639
Renal tubular injury 25.98 13.10 13 32485 617 29919363
Neuropathy peripheral 25.88 13.10 23 32475 70452 29849528
Non-cirrhotic portal hypertension 25.78 13.10 10 32488 255 29919725
Perinephric collection 25.57 13.10 9 32489 173 29919807
Aplasia pure red cell 25.49 13.10 31 32467 5595 29914385
Anogenital warts 25.41 13.10 12 32486 501 29919479
Mycobacterium haemophilum infection 25.33 13.10 6 32492 24 29919956
Epistaxis 25.19 13.10 13 32485 52968 29867012
Respiratory failure 25.09 13.10 191 32307 100451 29819529
Candida infection 25 13.10 53 32445 15309 29904671
Heart transplant rejection 24.81 13.10 16 32482 1237 29918743
Rheumatoid arthritis 24.74 13.10 7 32491 41190 29878790
Malaise 24.31 13.10 96 32402 166866 29753114
Nausea 24.26 13.10 206 32292 296751 29623229
Hernial eventration 24.08 13.10 7 32491 70 29919910
Coronary artery disease 23.93 13.10 12 32486 49700 29870280
Tubulointerstitial nephritis 23.83 13.10 57 32441 17834 29902146
Glomerulonephritis 23.82 13.10 18 32480 1795 29918185
Pneumocystis jirovecii infection 23.78 13.10 16 32482 1329 29918651
Encephalitis 23.71 13.10 32 32466 6404 29913576
Acute myocardial infarction 23.70 13.10 14 32484 52925 29867055
Nasal cavity cancer 23.64 13.10 8 32490 136 29919844
Wrong technique in product usage process 23.55 13.10 3 32495 31152 29888828
Nephrotic syndrome 23.51 13.10 33 32465 6852 29913128
Renal vein thrombosis 23.43 13.10 8 32490 140 29919840
Necrotising fasciitis fungal 23.33 13.10 5 32493 11 29919969
Vesicoureteral reflux surgery 23.31 13.10 4 32494 0 29919980
Seroma 23.23 13.10 12 32486 609 29919371
Erythema 23.18 13.10 30 32468 77421 29842559
Cholangitis 23.16 13.10 35 32463 7767 29912213
Disseminated varicella zoster virus infection 23.10 13.10 14 32484 970 29919010
Diffuse large B-cell lymphoma 23.02 13.10 35 32463 7806 29912174
Intentional product misuse 22.54 13.10 5 32493 34662 29885318
Isosporiasis 22.42 13.10 7 32491 91 29919889
Renal graft infection 22.41 13.10 9 32489 252 29919728
Insomnia 22.36 13.10 42 32456 93294 29826686
Cutaneous malacoplakia 22.29 13.10 6 32492 44 29919936
Hyperkalaemia 22.26 13.10 135 32363 65875 29854105
Fungal infection 22.22 13.10 47 32451 13553 29906427
Urinary tract infection bacterial 22.20 13.10 16 32482 1484 29918496
Transplantation complication 22.07 13.10 7 32491 96 29919884
Asthma 22.00 13.10 6 32492 36168 29883812
Glomerulonephritis membranoproliferative 21.91 13.10 10 32488 386 29919594
Hypersensitivity 21.87 13.10 16 32482 54012 29865968
Histoplasmosis cutaneous 21.75 13.10 5 32493 17 29919963
Renal tubular acidosis 21.56 13.10 17 32481 1805 29918175
Intra-abdominal haemorrhage 21.47 13.10 18 32480 2084 29917896
Plasma cell myeloma 21.43 13.10 16 32482 53446 29866534
Procedural pain 21.30 13.10 27 32471 5082 29914898
Drug interaction 21.29 13.10 319 32179 199249 29720731
Myopathy toxic 21.25 13.10 10 32488 414 29919566
Alveolar proteinosis 21.23 13.10 9 32489 290 29919690
Bacterial infection 21.09 13.10 44 32454 12566 29907414
Urticaria 21.05 13.10 17 32481 54589 29865391
Disease recurrence 20.93 13.10 47 32451 14114 29905866
Neurotoxicity 20.90 13.10 45 32453 13137 29906843
IgA nephropathy 20.83 13.10 13 32485 949 29919031
Neutrophil count decreased 20.81 13.10 10 32488 42444 29877536
Loss of consciousness 20.56 13.10 34 32464 79341 29840639
Large intestinal ulcer 20.53 13.10 16 32482 1670 29918310
Seizure 20.49 13.10 48 32450 98427 29821553
Bacterial sepsis 20.48 13.10 26 32472 4900 29915080
Gastroenteritis sapovirus 20.47 13.10 7 32491 123 29919857
Parvovirus infection 20.23 13.10 10 32488 462 29919518
End stage renal disease 20.17 13.10 32 32466 7403 29912577
Infected lymphocele 19.89 13.10 5 32493 27 29919953
Urosepsis 19.80 13.10 39 32459 10693 29909287
Chronic graft versus host disease in intestine 19.66 13.10 8 32490 232 29919748
Cardio-respiratory arrest 19.52 13.10 20 32478 57286 29862694
Death 19.49 13.10 272 32226 357011 29562969
Delusion of grandeur 19.44 13.10 9 32489 359 29919621
Complications of transplanted heart 19.41 13.10 8 32490 240 29919740
Acute graft versus host disease in intestine 19.38 13.10 18 32480 2387 29917593
Scleroderma 19.29 13.10 14 32484 1313 29918667
Herpes zoster oticus 19.29 13.10 6 32492 77 29919903
Asthenia 19.19 13.10 151 32347 221139 29698841
Febrile neutropenia 19.15 13.10 56 32442 106637 29813343
Optic discs blurred 19.08 13.10 6 32492 80 29919900
Blood creatine phosphokinase increased 19.07 13.10 12 32486 43836 29876144
Hemianopia heteronymous 19.03 13.10 5 32493 33 29919947
Blood pressure decreased 18.98 13.10 14 32484 47061 29872919
Eccrine squamous syringometaplasia 18.90 13.10 5 32493 34 29919946
Bacterial pyelonephritis 18.67 13.10 8 32490 265 29919715
Cardiac disorder 18.65 13.10 10 32488 39883 29880097
Suicidal ideation 18.49 13.10 8 32490 36106 29883874
Post procedural urine leak 18.48 13.10 7 32491 167 29919813
Retinal artery occlusion 18.41 13.10 15 32483 1669 29918311
Haemoglobinaemia 18.33 13.10 7 32491 171 29919809
Myocardial strain 18.25 13.10 6 32492 93 29919887
International normalised ratio increased 18.23 13.10 15 32483 47724 29872256
Haemolytic uraemic syndrome 18.13 13.10 16 32482 1986 29917994
Anorectal varices 18.09 13.10 5 32493 41 29919939
Feeling abnormal 18.01 13.10 21 32477 56735 29863245
Cardiac failure 17.89 13.10 40 32458 83378 29836602
Enterobacter infection 17.69 13.10 16 32482 2050 29917930
Pemphigus 17.64 13.10 13 32485 1248 29918732
Joint swelling 17.62 13.10 15 32483 46931 29873049
Muscle spasms 17.52 13.10 27 32471 64811 29855169
Chest pain 17.51 13.10 67 32431 117560 29802420
Ureteral catheterisation 17.48 13.10 3 32495 0 29919980
Acute graft versus host disease in skin 17.47 13.10 23 32475 4493 29915487
Suicide attempt 17.45 13.10 9 32489 36688 29883292
Paraesthesia 17.35 13.10 20 32478 54307 29865673
Hypotension 17.32 13.10 137 32361 200428 29719552
Fungal skin infection 17.31 13.10 17 32481 2415 29917565
Leishmaniasis 17.28 13.10 8 32490 319 29919661
Anti-erythropoietin antibody negative 17.27 13.10 7 32491 201 29919779
Systemic candida 17.26 13.10 18 32480 2746 29917234
Human polyomavirus infection 17.23 13.10 10 32488 640 29919340
Hypoglycaemia 17.13 13.10 18 32480 50963 29869017
Inappropriate schedule of product administration 17.10 13.10 11 32487 39717 29880263
Renal cancer stage I 17.09 13.10 4 32494 15 29919965
Liver transplant 17.06 13.10 18 32480 2784 29917196
Pneumonia pseudomonal 16.95 13.10 20 32478 3498 29916482
Superinfection bacterial 16.89 13.10 9 32489 487 29919493
Cytomegalovirus nephritis 16.87 13.10 6 32492 119 29919861
Secondary immunodeficiency 16.85 13.10 8 32490 338 29919642
Hallucination 16.85 13.10 17 32481 49042 29870938
Glomerulonephritis proliferative 16.83 13.10 7 32491 215 29919765
Biliary anastomosis complication 16.83 13.10 6 32492 120 29919860
Drug reaction with eosinophilia and systemic symptoms 16.81 13.10 5 32493 28483 29891497
Platelet count decreased 16.75 13.10 59 32439 106070 29813910
Lung transplant 16.73 13.10 15 32483 1901 29918079
Incisional hernia 16.72 13.10 12 32486 1106 29918874
Human herpesvirus 8 infection 16.68 13.10 10 32488 679 29919301
Nephrostomy 16.56 13.10 7 32491 224 29919756
Argentine haemorrhagic fever 16.51 13.10 4 32494 18 29919962
Renal lymphocele 16.45 13.10 5 32493 59 29919921
Urinary fistula 16.38 13.10 6 32492 130 29919850
Hypogammaglobulinaemia 16.21 13.10 24 32474 5228 29914752
Back pain 16.21 13.10 57 32441 102539 29817441
Postoperative wound infection 16.18 13.10 22 32476 4433 29915547
Epstein-Barr virus associated lymphoma 16.02 13.10 9 32489 541 29919439
Periostitis 15.95 13.10 7 32491 246 29919734
Chronic kidney disease-mineral and bone disorder 15.94 13.10 8 32490 382 29919598
Functional gastrointestinal disorder 15.93 13.10 15 32483 2024 29917956
Depressed level of consciousness 15.89 13.10 11 32487 38211 29881769
Product dose omission issue 15.79 13.10 49 32449 91582 29828398
Respiratory arrest 15.76 13.10 6 32492 29252 29890728
Metastatic squamous cell carcinoma 15.71 13.10 8 32490 394 29919586
Propionibacterium infection 15.66 13.10 7 32491 257 29919723
Pyrexia 15.65 13.10 424 32074 294065 29625915
Lung transplant rejection 15.64 13.10 10 32488 762 29919218
Metabolic acidosis 15.53 13.10 81 32417 37380 29882600
Angioedema 15.52 13.10 9 32489 34375 29885605
Enterovirus infection 15.46 13.10 9 32489 579 29919401
Cranial nerve paralysis 15.41 13.10 4 32494 25 29919955
Balamuthia infection 15.41 13.10 3 32495 3 29919977
Musculoskeletal stiffness 15.35 13.10 10 32488 35871 29884109
Electrocardiogram QT prolonged 15.31 13.10 10 32488 35825 29884155
Dysgeusia 15.29 13.10 4 32494 24797 29895183
Mycobacterium chelonae infection 15.22 13.10 9 32489 596 29919384
Creatinine urine increased 15.18 13.10 6 32492 161 29919819
Urine output decreased 15.18 13.10 33 32465 9696 29910284
Malacoplakia gastrointestinal 15.12 13.10 5 32493 79 29919901
Peripheral swelling 15.05 13.10 27 32471 61047 29858933
Multiple organ dysfunction syndrome 14.98 13.10 119 32379 63368 29856612
Catatonia 14.96 13.10 21 32477 4359 29915621
Leuconostoc infection 14.94 13.10 3 32495 4 29919976
Aggression 14.84 13.10 11 32487 36896 29883084
Foetal exposure during pregnancy 14.82 13.10 11 32487 36860 29883120
Lymphorrhoea 14.78 13.10 5 32493 85 29919895
Herpes zoster cutaneous disseminated 14.75 13.10 6 32492 174 29919806
Stenotrophomonas infection 14.74 13.10 13 32485 1611 29918369
Gingival hypertrophy 14.68 13.10 13 32485 1620 29918360
Drug level fluctuating 14.60 13.10 8 32490 458 29919522
Prophylaxis against transplant rejection 14.56 13.10 4 32494 32 29919948
Central nervous system lesion 14.55 13.10 22 32476 4884 29915096
Arteriovenous fistula aneurysm 14.55 13.10 3 32495 5 29919975
Pyuria 14.54 13.10 9 32489 648 29919332
Hospitalisation 14.53 13.10 90 32408 44229 29875751
Spindle cell sarcoma 14.46 13.10 5 32493 91 29919889
Epidermodysplasia verruciformis 14.45 13.10 4 32494 33 29919947
Herpes simplex hepatitis 14.41 13.10 5 32493 92 29919888
Staphylococcal infection 14.40 13.10 68 32430 30156 29889824
Injury 14.40 13.10 3 32495 21728 29898252
Mouth ulceration 14.34 13.10 34 32464 10575 29909405
Abdominal wall abscess 14.15 13.10 8 32490 487 29919493
Brain compression 14.14 13.10 6 32492 194 29919786
Visceral leishmaniasis 14.13 13.10 8 32490 488 29919492
Cerebrovascular accident 14.13 13.10 45 32453 83432 29836548
Gastroenteritis cryptosporidial 14.11 13.10 6 32492 195 29919785
Epstein-Barr viraemia 14.08 13.10 10 32488 906 29919074
Chronic hepatitis C 14.07 13.10 8 32490 492 29919488
Pancreas transplant 13.95 13.10 4 32494 38 29919942
Pain in extremity 13.81 13.10 67 32431 110154 29809826
Cytomegalovirus gastroenteritis 13.75 13.10 6 32492 208 29919772
Skin necrosis 13.74 13.10 21 32477 4706 29915274
White blood cell count decreased 13.69 13.10 46 32452 83901 29836079
Cutaneous mucormycosis 13.67 13.10 4 32494 41 29919939
Intestine transplant rejection 13.67 13.10 4 32494 41 29919939
Biopsy kidney abnormal 13.66 13.10 5 32493 108 29919872
Histoplasmosis disseminated 13.62 13.10 10 32488 954 29919026
Acinetobacter bacteraemia 13.62 13.10 5 32493 109 29919871
Endocarditis viral 13.59 13.10 3 32495 8 29919972
Meningoencephalitis viral 13.54 13.10 5 32493 111 29919869
Cytomegalovirus mucocutaneous ulcer 13.42 13.10 4 32494 44 29919936
Nodular regenerative hyperplasia 13.40 13.10 9 32489 745 29919235
Cytomegalovirus syndrome 13.37 13.10 5 32493 115 29919865
Low density lipoprotein increased 13.34 13.10 19 32479 3997 29915983
Herpes zoster 13.29 13.10 66 32432 29877 29890103
Balance disorder 13.28 13.10 12 32486 36481 29883499
Ureteric anastomosis complication 13.18 13.10 4 32494 47 29919933
Oesophageal ulcer 13.16 13.10 17 32481 3260 29916720

Pharmacologic Action:

SourceCodeDescription
ATC L04AA06 ANTINEOPLASTIC AND IMMUNOMODULATING AGENTS
IMMUNOSUPPRESSANTS
IMMUNOSUPPRESSANTS
Selective immunosuppressants
FDA EPC N0000175613 Antimetabolite Immunosuppressant
MeSH PA D000900 Anti-Bacterial Agents
MeSH PA D000890 Anti-Infective Agents
MeSH PA D000903 Antibiotics, Antineoplastic
MeSH PA D000904 Antibiotics, Antitubercular
MeSH PA D000970 Antineoplastic Agents
MeSH PA D000995 Antitubercular Agents
MeSH PA D004791 Enzyme Inhibitors
CHEBI has role CHEBI:35705 immunosuppressant
CHEBI has role CHEBI:53746 imp dehydrogenase (ec 1.1.1.205) inhibitor
CHEBI has role CHEBI:25442 mycotoxins
CHEBI has role CHEBI:33281 antibiotics
CHEBI has role CHEBI:35610 cytostatic
CHEBI has role CHEBI:35703 xenobiotic
CHEBI has role CHEBI:76964 penicillium metabolites
CHEBI has role CHEBI:78298 environmental contaminants
CHEBI has role CHEBI:149553 anti-coronaviral agents

Drug Use (View source of the data)

DiseaseRelationSNOMED_IDDOID
Prevention of Liver Transplant Rejection indication
Prevention of Cardiac Transplant Rejection indication
Prevention of Kidney Transplant Rejection indication
Prevention of Lung Transplant Rejection off-label use
Herpes zoster contraindication 4740000 DOID:8536
Progressive multifocal leukoencephalopathy contraindication 22255007 DOID:643
Cytomegalovirus infection contraindication 28944009
Constitutional aplastic anemia contraindication 28975000 DOID:1342
Gastrointestinal ulcer contraindication 40845000
Gastrointestinal perforation contraindication 51875005
Acute nephropathy contraindication 58574008
Acute infectious disease contraindication 63171007
Gastrointestinal hemorrhage contraindication 74474003
Herpes simplex contraindication 88594005 DOID:8566
Malignant lymphoma contraindication 118600007 DOID:0060058
Deficiency of hypoxanthine phosphoribosyltransferase contraindication 124275001
Disease of liver contraindication 235856003 DOID:409
Pregnancy, function contraindication 289908002
Neutropenic disorder contraindication 303011007 DOID:1227
Bone marrow depression contraindication 307762000
Primary malignant neoplasm contraindication 372087000
Malignant neoplasm of skin contraindication 372130007 DOID:4159
Breastfeeding (mother) contraindication 413712001
Opportunistic Fungal Infection contraindication
BK Polyomavirus Reactivation Nephropathy contraindication

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 4.67 acidic
pKa2 11.03 acidic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
Inosine-5'-monophosphate dehydrogenase (IMPDH) Enzyme INHIBITOR IC50 4.70 CHEMBL CHEMBL
Inosine-5'-monophosphate dehydrogenase 2 Enzyme Ki 8.22 CHEMBL
Inosine-5'-monophosphate dehydrogenase 1 Enzyme Ki 7.48 CHEMBL

External reference:

IDSource
4025608 VUID
N0000176078 NUI
D05095 KEGG_DRUG
24280-93-1 SECONDARY_CAS_RN
4021418 VANDF
4025598 VANDF
4025608 VANDF
C0883242 UMLSCUI
CHEBI:168396 CHEBI
MOA PDB_CHEM_ID
CHEMBL2106643 ChEMBL_ID
CHEMBL866 ChEMBL_ID
D009173 MESH_DESCRIPTOR_UI
DB01024 DRUGBANK_ID
6832 IUPHAR_LIGAND_ID
2950 INN_ID
WX877SQI1G UNII
446541 PUBCHEM_CID
265323 RXNORM
18132 MMSL
210716 MMSL
d05217 MMSL
005013 NDDF
009984 NDDF
409330005 SNOMEDCT_US
409331009 SNOMEDCT_US
426216009 SNOMEDCT_US

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
Myfortic HUMAN PRESCRIPTION DRUG LABEL 1 0078-0385 TABLET, DELAYED RELEASE 180 mg ORAL NDA 29 sections
Myfortic HUMAN PRESCRIPTION DRUG LABEL 1 0078-0386 TABLET, DELAYED RELEASE 360 mg ORAL NDA 29 sections
Mycophenolic Acid HUMAN PRESCRIPTION DRUG LABEL 1 0378-4201 TABLET, DELAYED RELEASE 180 mg ORAL ANDA 29 sections
Mycophenolic Acid HUMAN PRESCRIPTION DRUG LABEL 1 0378-4202 TABLET, DELAYED RELEASE 360 mg ORAL ANDA 29 sections
Mycophenolic Acid HUMAN PRESCRIPTION DRUG LABEL 1 0904-6785 TABLET, DELAYED RELEASE 180 mg ORAL ANDA 20 sections
Mycophenolic Acid HUMAN PRESCRIPTION DRUG LABEL 1 0904-6786 TABLET, DELAYED RELEASE 360 mg ORAL ANDA 20 sections
Mycophenolic Acid HUMAN PRESCRIPTION DRUG LABEL 1 16729-189 TABLET, DELAYED RELEASE 360 mg ORAL ANDA 27 sections
Mycophenolic Acid HUMAN PRESCRIPTION DRUG LABEL 1 16729-261 TABLET, DELAYED RELEASE 180 mg ORAL ANDA 27 sections
Mycophenolic Acid HUMAN PRESCRIPTION DRUG LABEL 1 50268-559 TABLET, DELAYED RELEASE 180 mg ORAL ANDA 23 sections
Mycophenolic Acid HUMAN PRESCRIPTION DRUG LABEL 1 50268-560 TABLET, DELAYED RELEASE 360 mg ORAL ANDA 23 sections
Mycophenolic Acid HUMAN PRESCRIPTION DRUG LABEL 1 51079-508 TABLET, DELAYED RELEASE 180 mg ORAL ANDA 28 sections
Mycophenolic Acid HUMAN PRESCRIPTION DRUG LABEL 1 51079-509 TABLET, DELAYED RELEASE 360 mg ORAL ANDA 28 sections
Mycophenolic Acid HUMAN PRESCRIPTION DRUG LABEL 1 60429-016 TABLET, DELAYED RELEASE 180 mg ORAL ANDA 23 sections
Mycophenolic Acid HUMAN PRESCRIPTION DRUG LABEL 1 60429-017 TABLET, DELAYED RELEASE 360 mg ORAL ANDA 23 sections
Mycophenolic Acid HUMAN PRESCRIPTION DRUG LABEL 1 60505-2965 TABLET, DELAYED RELEASE 180 mg ORAL ANDA 23 sections
Mycophenolic Acid HUMAN PRESCRIPTION DRUG LABEL 1 60505-2966 TABLET, DELAYED RELEASE 360 mg ORAL ANDA 23 sections
Mycophenolic Acid HUMAN PRESCRIPTION DRUG LABEL 1 68084-907 TABLET, DELAYED RELEASE 180 mg ORAL ANDA 20 sections
Mycophenolic Acid HUMAN PRESCRIPTION DRUG LABEL 1 68084-918 TABLET, DELAYED RELEASE 360 mg ORAL ANDA 20 sections
mycophenolic acid HUMAN PRESCRIPTION DRUG LABEL 1 68254-5001 TABLET, DELAYED RELEASE 180 mg ORAL ANDA 26 sections
mycophenolic acid HUMAN PRESCRIPTION DRUG LABEL 1 68254-5002 TABLET, DELAYED RELEASE 360 mg ORAL ANDA 26 sections
Mycophenolic Acid HUMAN PRESCRIPTION DRUG LABEL 1 70436-172 TABLET, DELAYED RELEASE 180 mg ORAL ANDA 29 sections
Mycophenolic Acid HUMAN PRESCRIPTION DRUG LABEL 1 70436-173 TABLET, DELAYED RELEASE 360 mg ORAL ANDA 29 sections
mycophenolic acid HUMAN PRESCRIPTION DRUG LABEL 1 70748-217 TABLET, DELAYED RELEASE 180 mg ORAL ANDA 26 sections
mycophenolic acid HUMAN PRESCRIPTION DRUG LABEL 1 70748-218 TABLET, DELAYED RELEASE 360 mg ORAL ANDA 26 sections