mycophenolic acid Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definition	Drug id	CAS RN
	1860	37415-62-6

Description:

Molecule

Description

Molfile Inchi Smiles Synonyms: mycophenolate mycophenolic acid mycophenolate sodium mycophenolic acid monosodium salt sodium mycophenolate

Compound derived from Penicillium stoloniferum and related species. It blocks de novo biosynthesis of purine nucleotides by inhibition of the enzyme inosine monophosphate dehydrogenase (IMP DEHYDROGENASE). Mycophenolic acid exerts selective effects on the immune system in which it prevents the proliferation of T-CELLS, LYMPHOCYTES, and the formation of antibodies from B-CELLS. It may also inhibit recruitment of LEUKOCYTES to sites of INFLAMMATION. Molecular weight: 320.34 Formula: C17H20O6 CLOGP: 2.29 LIPINSKI: 0 HAC: 6 HDO: 2 TPSA: 93.06 ALOGS: -3.96 ROTB: 6 Status: OFP Legend: OFP - off patent OFM - off market ONP - on patent

Drug dosage:

Dose	Unit	Route
2	g	O
2	g	P

ADMET properties:

Property	Value	Reference
BDDCS (Biopharmaceutical Drug Disposition Classification System)	2	Benet LZ, Broccatelli F, Oprea TI
EoM (Fraction excreted unchanged in urine)	0.50 %	Benet LZ, Broccatelli F, Oprea TI
MRTD (Maximum Recommended Therapeutic Daily Dose)	64.22 µM/kg/day	Contrera JF, Matthews EJ, Kruhlak NL, Benz RD
Vd (Volume of distribution)	0.77 L/kg	Lombardo F, Berellini G, Obach RS
CL (Clearance)	2.33 mL/min/kg	Lombardo F, Berellini G, Obach RS
fu (Fraction unbound in plasma)	0.02 %	Lombardo F, Berellini G, Obach RS
t_half (Half-life)	9.70 hours	Lombardo F, Berellini G, Obach RS

Approvals:

Date	Agency	Company	Orphan
Feb. 27, 2004	FDA	NOVARTIS

FDA Adverse Event Reporting System (Female)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Cytomegalovirus infection	663.43	12.22	283	26506	17861	46641412
Transplant rejection	488.96	12.22	190	26599	9406	46649867
Kidney transplant rejection	405.73	12.22	133	26656	3985	46655288
Post transplant lymphoproliferative disorder	314.32	12.22	108	26681	3748	46655525
Complications of transplanted kidney	292.92	12.22	90	26699	2173	46657100
Thrombotic microangiopathy	246.56	12.22	112	26677	8194	46651079
Polyomavirus-associated nephropathy	230.52	12.22	68	26721	1422	46657851
Product use in unapproved indication	196.06	12.22	250	26539	90023	46569250
BK virus infection	190.96	12.22	69	26720	2780	46656493
Cytomegalovirus viraemia	177.33	12.22	74	26715	4404	46654869
COVID-19	176.58	12.22	118	26671	18457	46640816
Epstein-Barr virus infection	168.87	12.22	81	26708	6703	46652570
Posterior reversible encephalopathy syndrome	165.52	12.22	105	26684	15036	46644237
Leukopenia	155.83	12.22	194	26595	68149	46591124
Immunosuppressant drug level increased	153.10	12.22	61	26728	3221	46656052
Delayed graft function	131.29	12.22	40	26749	937	46658336
Kidney fibrosis	128.24	12.22	43	26746	1382	46657891
Chronic allograft nephropathy	123.93	12.22	35	26754	623	46658650
Off label use	119.81	12.22	482	26307	379359	46279914
Pneumocystis jirovecii pneumonia	112.59	12.22	83	26706	15165	46644108
Blood creatinine increased	108.64	12.22	173	26616	76230	46583043
Renal impairment	91.74	12.22	158	26631	74214	46585059
West Nile viral infection	88.13	12.22	24	26765	371	46658902
Varicella zoster virus infection	87.02	12.22	37	26752	2306	46656967
Lymphocele	82.25	12.22	27	26762	811	46658462
Tubulointerstitial nephritis	82.07	12.22	68	26721	14720	46644553
Aspergillus infection	80.86	12.22	50	26739	6840	46652433
Renal transplant failure	80.17	12.22	25	26764	634	46658639
Nephropathy toxic	79.72	12.22	51	26738	7403	46651870
Multiple organ dysfunction syndrome	78.91	12.22	121	26668	51589	46607684
Epstein-Barr viraemia	77.42	12.22	25	26764	712	46658561
Post transplant distal limb syndrome	76.75	12.22	19	26770	197	46659076
Histoplasmosis disseminated	74.53	12.22	27	26762	1095	46658178
Escherichia infection	73.44	12.22	56	26733	10761	46648512
Apoptosis	71.16	12.22	15	26774	69	46659204
Graft versus host disease in skin	70.48	12.22	32	26757	2335	46656938
Graft loss	70.24	12.22	20	26769	367	46658906
Human herpesvirus 6 infection	69.56	12.22	32	26757	2407	46656866
Graft versus host disease in gastrointestinal tract	68.20	12.22	32	26757	2518	46656755
Graft versus host disease	67.80	12.22	44	26745	6544	46652729
Transplant dysfunction	65.38	12.22	38	26751	4644	46654629
Trichodysplasia spinulosa	63.83	12.22	19	26770	410	46658863
Liver transplant rejection	62.06	12.22	25	26764	1358	46657915
Central nervous system lymphoma	57.42	12.22	23	26766	1231	46658042
Polyomavirus viraemia	56.72	12.22	17	26772	376	46658897
Adenovirus infection	56.23	12.22	29	26760	2801	46656472
Klebsiella infection	55.43	12.22	39	26750	6623	46652650
Ureaplasma infection	54.04	12.22	17	26772	444	46658829
Respiratory failure	53.68	12.22	147	26642	94669	46564604
Renal transplant	53.12	12.22	22	26767	1283	46657990
Fall	51.66	12.22	68	26721	329029	46330244
Renal tubular atrophy	51.65	12.22	17	26772	515	46658758
Drug hypersensitivity	51.28	12.22	39	26750	243786	46415487
Fatigue	50.49	12.22	180	26609	608517	46050756
Parvovirus B19 infection	50.12	12.22	15	26774	330	46658943
Blastomycosis	49.58	12.22	14	26775	249	46659024
Acute kidney injury	48.05	12.22	264	26525	235591	46423682
JC virus infection	48.01	12.22	22	26767	1640	46657633
Pancreas transplant rejection	47.74	12.22	12	26777	133	46659140
Human ehrlichiosis	47.73	12.22	13	26776	201	46659072
Viraemia	47.46	12.22	19	26770	1015	46658258
Cryptococcosis	47.40	12.22	18	26771	834	46658439
Cytomegalovirus colitis	47.11	12.22	22	26767	1713	46657560
Bronchopulmonary aspergillosis	46.95	12.22	37	26752	7459	46651814
Diffuse large B-cell lymphoma	43.10	12.22	32	26757	5906	46653367
Focal segmental glomerulosclerosis	41.64	12.22	19	26770	1402	46657871
Pain	40.85	12.22	139	26650	476809	46182464
Disseminated mucormycosis	39.45	12.22	10	26779	115	46659158
Haemolytic uraemic syndrome	39.39	12.22	22	26767	2492	46656781
Diabetes mellitus	39.31	12.22	88	26701	49977	46609296
Encephalitis viral	39.16	12.22	19	26770	1611	46657662
Immunosuppressant drug level decreased	38.92	12.22	16	26773	916	46658357
Histoplasmosis	38.50	12.22	19	26770	1671	46657602
Alveolar proteinosis	38.27	12.22	12	26777	310	46658963
Drug level increased	38.26	12.22	50	26739	18391	46640882
Biopsy lung abnormal	37.84	12.22	10	26779	137	46659136
Pyrexia	37.52	12.22	334	26455	348468	46310805
Phaeohyphomycosis	37.24	12.22	11	26778	231	46659042
Atypical haemolytic uraemic syndrome	37.18	12.22	13	26776	475	46658798
Nocardiosis	36.31	12.22	18	26771	1599	46657674
Renal tubular necrosis	35.45	12.22	37	26752	10722	46648551
Rheumatoid arthritis	35.29	12.22	52	26737	240163	46419110
Injection site pain	35.24	12.22	9	26780	107143	46552130
Human polyomavirus infection	33.90	12.22	10	26779	209	46659064
Toxoplasmosis	32.74	12.22	16	26773	1378	46657895
Aplasia pure red cell	32.46	12.22	24	26765	4401	46654872
Enterococcal infection	32.40	12.22	29	26760	6958	46652315
Arthropathy	32.27	12.22	5	26784	84695	46574578
Injection site erythema	31.77	12.22	3	26786	74424	46584849
Rhodococcus infection	31.64	12.22	8	26781	91	46659182
Hepatitis E	31.45	12.22	15	26774	1224	46658049
Diarrhoea	31.36	12.22	472	26317	559130	46100143
Arthralgia	31.34	12.22	106	26683	364497	46294776
Dizziness	31.32	12.22	96	26693	340318	46318955
Depression	31.14	12.22	31	26758	170073	46489200
Interstitial lung disease	30.86	12.22	84	26705	53865	46605408
Malacoplakia vesicae	30.48	12.22	7	26782	51	46659222
Rash	30.40	12.22	104	26685	356408	46302865
Human herpesvirus 6 encephalitis	30.11	12.22	8	26781	112	46659161
Cystitis haemorrhagic	30.05	12.22	21	26768	3526	46655747
Proteinuria	29.95	12.22	42	26747	16511	46642762
Acute graft versus host disease	29.88	12.22	22	26767	4008	46655265
Acute graft versus host disease in intestine	29.78	12.22	16	26773	1679	46657594
Biloma	29.47	12.22	7	26782	60	46659213
Malacoplakia gastrointestinal	29.17	12.22	7	26782	63	46659210
Haemolytic anaemia	29.17	12.22	32	26757	9810	46649463
Psoriasis	29.14	12.22	5	26784	78599	46580674
Obliterative bronchiolitis	29.09	12.22	16	26773	1759	46657514
Microsporidia infection	28.65	12.22	9	26780	234	46659039
Gastroenteritis norovirus	28.06	12.22	15	26774	1558	46657715
Escherichia urinary tract infection	27.91	12.22	32	26757	10291	46648982
Donor specific antibody present	27.57	12.22	6	26783	33	46659240
Progressive multifocal leukoencephalopathy	27.09	12.22	33	26756	11313	46647960
Disseminated mycobacterium avium complex infection	26.46	12.22	6	26783	41	46659232
End stage renal disease	26.45	12.22	24	26765	5862	46653411
Anxiety	26.11	12.22	40	26749	181917	46477356
Graft complication	26.03	12.22	8	26781	193	46659080
Hydronephrosis	25.70	12.22	28	26761	8517	46650756
Mycobacterium avium complex infection	25.58	12.22	17	26772	2631	46656642
Bacterial pyelonephritis	25.48	12.22	9	26780	339	46658934
Constipation	25.24	12.22	38	26751	174059	46485214
Cytomegalovirus nephritis	24.92	12.22	5	26784	17	46659256
Hyperammonaemia	24.74	12.22	21	26768	4695	46654578
Anogenital warts	24.52	12.22	9	26780	379	46658894
Malignant neoplasm progression	24.35	12.22	4	26785	64922	46594351
Incision site pain	24.32	12.22	12	26777	1055	46658218
Pseudomonas infection	24.31	12.22	29	26760	9729	46649544
Herpes simplex oesophagitis	24.21	12.22	7	26782	136	46659137
Disseminated varicella zoster vaccine virus infection	24.17	12.22	6	26783	63	46659210
Brain abscess	24.16	12.22	14	26775	1701	46657572
Hypogammaglobulinaemia	24.10	12.22	22	26767	5416	46653857
Perinephric abscess	23.79	12.22	7	26782	145	46659128
Urinary fistula	23.72	12.22	5	26784	23	46659250
Acute respiratory distress syndrome	23.69	12.22	44	26745	21878	46637395
Pyelonephritis	23.49	12.22	36	26753	15321	46643952
Coccidioidomycosis	23.36	12.22	11	26778	872	46658401
Pruritus	23.24	12.22	67	26722	242285	46416988
Necrotising herpetic retinopathy	23.21	12.22	6	26783	75	46659198
Lupus nephritis	23.11	12.22	15	26774	2231	46657042
Renal failure	22.96	12.22	127	26662	113467	46545806
Insomnia	22.95	12.22	37	26752	164887	46494386
Pyelonephritis acute	22.91	12.22	19	26770	4115	46655158
Herpes simplex hepatitis	22.83	12.22	8	26781	294	46658979
Haemophagocytic lymphohistiocytosis	22.79	12.22	26	26763	8316	46650957
Polyomavirus test positive	22.45	12.22	6	26783	86	46659187
Cytomegalovirus hepatitis	22.23	12.22	8	26781	318	46658955
Mycobacterial infection	22.13	12.22	13	26776	1620	46657653
Agranulocytosis	22.09	12.22	43	26746	22142	46637131
Lung transplant	21.92	12.22	16	26773	2876	46656397
Hospitalisation	21.89	12.22	83	26706	63302	46595971
Papilloma viral infection	21.61	12.22	12	26777	1344	46657929
Tuberculosis gastrointestinal	21.42	12.22	8	26781	354	46658919
Hypoaesthesia	21.36	12.22	22	26767	118847	46540426
Disseminated cytomegaloviral infection	21.34	12.22	6	26783	105	46659168
Infection reactivation	21.31	12.22	10	26779	787	46658486
Cytomegalovirus syndrome	21.18	12.22	6	26783	108	46659165
Back pain	20.92	12.22	57	26732	209982	46449291
Mucinous adenocarcinoma of appendix	20.85	12.22	4	26785	10	46659263
Lymphopenia	20.84	12.22	34	26755	15259	46644014
Liver abscess	20.81	12.22	15	26774	2644	46656629
Escherichia pyelonephritis	20.80	12.22	8	26781	384	46658889
Osteoarthritis	20.80	12.22	5	26784	62020	46597253
Urinoma	20.73	12.22	5	26784	46	46659227
Complications of transplanted lung	20.67	12.22	7	26782	232	46659041
Pneumopericardium	20.54	12.22	5	26784	48	46659225
Systemic candida	20.47	12.22	15	26774	2712	46656561
Cytomegalovirus chorioretinitis	20.43	12.22	12	26777	1495	46657778
Mucormycosis	20.43	12.22	14	26775	2278	46656995
Pain in extremity	20.34	12.22	78	26711	258602	46400671
Intentional overdose	20.33	12.22	6	26783	64938	46594335
Systemic bacterial infection	20.32	12.22	4	26785	12	46659261
Dermatitis papillaris capillitii	20.32	12.22	4	26785	12	46659261
Urinary tract infection	20.17	12.22	204	26585	220062	46439211
Septic shock	20.15	12.22	76	26713	57817	46601456
Pyelonephritis fungal	20.13	12.22	6	26783	130	46659143
Nephrotic syndrome	20.05	12.22	19	26770	4902	46654371
Suicidal ideation	20.01	12.22	4	26785	56378	46602895
Diabetic macroangiopathy	19.88	12.22	6	26783	136	46659137
Chronic kidney disease	19.84	12.22	60	26729	40811	46618462
Transplant failure	19.72	12.22	11	26778	1243	46658030
Mycobacterium chelonae infection	19.71	12.22	8	26781	443	46658830
Ureteral necrosis	19.68	12.22	5	26784	58	46659215
American trypanosomiasis	19.45	12.22	5	26784	61	46659212
Epstein-Barr virus associated lymphoma	19.30	12.22	7	26782	285	46658988
Disseminated cryptococcosis	19.27	12.22	7	26782	286	46658987
Heart transplant rejection	19.16	12.22	8	26781	476	46658797
Acute motor axonal neuropathy	19.05	12.22	4	26785	18	46659255
Drug level decreased	18.88	12.22	20	26769	5892	46653381
Red blood cells urine positive	18.81	12.22	14	26775	2593	46656680
Concomitant disease progression	18.79	12.22	13	26776	2149	46657124
Cat scratch disease	18.78	12.22	6	26783	165	46659108
Gastrointestinal mucormycosis	18.78	12.22	6	26783	165	46659108
Rhinovirus infection	18.69	12.22	16	26773	3620	46655653
Lung transplant rejection	18.58	12.22	9	26780	760	46658513
Emphysematous pyelonephritis	18.44	12.22	6	26783	175	46659098
Urinary tract candidiasis	18.39	12.22	8	26781	527	46658746
Balance disorder	18.38	12.22	7	26782	64514	46594759
Bacillary angiomatosis	18.32	12.22	5	26784	78	46659195
Chronic graft versus host disease	18.26	12.22	14	26775	2711	46656562
Joint swelling	18.13	12.22	43	26746	166030	46493243
Smooth muscle cell neoplasm	18.00	12.22	8	26781	555	46658718
Human herpesvirus 8 infection	17.89	12.22	6	26783	193	46659080
Malacoplakia	17.86	12.22	5	26784	86	46659187
Renal lymphocele	17.81	12.22	5	26784	87	46659186
Pulmonary mucormycosis	17.55	12.22	5	26784	92	46659181
Intentional product use issue	17.31	12.22	68	26721	52712	46606561
Neutrophil count increased	17.18	12.22	30	26759	14223	46645050
Sepsis	17.08	12.22	135	26654	135879	46523394
Purulent pericarditis	16.87	12.22	4	26785	34	46659239
Pulmonary alveolar haemorrhage	16.82	12.22	16	26773	4146	46655127
Encephalitis	16.71	12.22	21	26768	7427	46651846
Joint tuberculosis	16.54	12.22	5	26784	114	46659159
Myocardial infarction	16.46	12.22	19	26770	97509	46561764
Pancytopenia	16.46	12.22	94	26695	84964	46574309
Colitis	16.44	12.22	53	26736	37294	46621979
Biopsy kidney	16.33	12.22	5	26784	119	46659154
Cardiac murmur functional	16.29	12.22	4	26785	40	46659233
Graft versus host disease in liver	16.24	12.22	7	26782	451	46658822
Orbital apex syndrome	16.20	12.22	4	26785	41	46659232
Acid base balance abnormal	16.10	12.22	6	26783	264	46659009
Chronic kidney disease-mineral and bone disorder	16.10	12.22	6	26783	264	46659009
Bacteraemia	16.00	12.22	29	26760	14150	46645123
Disseminated tuberculosis	15.99	12.22	13	26776	2739	46656534
Plasmapheresis	15.97	12.22	6	26783	270	46659003
Nephrostomy	15.94	12.22	4	26785	44	46659229
Somnolence	15.93	12.22	42	26747	156479	46502794
Contusion	15.93	12.22	16	26773	87471	46571802
Bronchiectasis	15.91	12.22	23	26766	9293	46649980
Cytomegalovirus gastrointestinal infection	15.78	12.22	6	26783	279	46658994
Acanthamoeba infection	15.78	12.22	4	26785	46	46659227
Necrotising retinitis	15.62	12.22	6	26783	287	46658986
Pancreatitis necrotising	15.58	12.22	10	26779	1459	46657814
Epstein-Barr virus associated lymphoproliferative disorder	15.52	12.22	10	26779	1469	46657804
Encephalitis cytomegalovirus	15.36	12.22	7	26782	515	46658758
Cardiac failure congestive	15.35	12.22	18	26771	91732	46567541
Brain natriuretic peptide increased	15.33	12.22	16	26773	4634	46654639
Scedosporium infection	15.31	12.22	7	26782	519	46658754
Drug resistance	15.31	12.22	32	26757	17336	46641937
Asthma	15.27	12.22	18	26771	91524	46567749
Meningitis histoplasma	15.24	12.22	3	26786	9	46659264
Chronic obstructive pulmonary disease	15.21	12.22	7	26782	57626	46601647
Pneumonia cytomegaloviral	15.21	12.22	11	26778	1949	46657324
Fungal sepsis	15.20	12.22	9	26780	1138	46658135
Influenza like illness	15.19	12.22	7	26782	57563	46601710
Fungaemia	15.06	12.22	11	26778	1980	46657293
Dermatomyositis	14.91	12.22	11	26778	2010	46657263
Graft versus host disease in lung	14.86	12.22	6	26783	328	46658945
Mucocutaneous leishmaniasis	14.80	12.22	6	26783	331	46658942
Hypersensitivity	14.80	12.22	41	26748	150280	46508993
Strongyloidiasis	14.74	12.22	8	26781	857	46658416
Bacterial colitis	14.68	12.22	4	26785	62	46659211
Organising pneumonia	14.63	12.22	16	26773	4886	46654387
Nosocomial infection	14.60	12.22	10	26779	1625	46657648
Graft versus host disease in eye	14.56	12.22	4	26785	64	46659209
Anorexia nervosa	14.40	12.22	5	26784	179	46659094
Urosepsis	14.37	12.22	29	26760	15324	46643949
Hyperamylasaemia	14.26	12.22	6	26783	364	46658909
Reversible cerebral vasoconstriction syndrome	14.16	12.22	10	26779	1707	46657566
Lymphoproliferative disorder	14.15	12.22	12	26777	2680	46656593
Mycobacterium abscessus infection	14.15	12.22	7	26782	619	46658654
Contraindicated product administered	14.12	12.22	15	26774	79932	46579341
Herpes simplex	14.08	12.22	19	26770	7204	46652069
Aphthous ulcer	14.07	12.22	22	26767	9526	46649747
Protein urine present	14.03	12.22	16	26773	5115	46654158
Gastroenteritis cryptosporidial	13.97	12.22	4	26785	75	46659198
B-cell lymphoma	13.96	12.22	13	26776	3281	46655992
Asthenia	13.92	12.22	113	26676	310962	46348311
Transplant	13.83	12.22	7	26782	650	46658623
Renal disorder	13.73	12.22	40	26749	26646	46632627
Superinfection bacterial	13.73	12.22	6	26783	400	46658873
Anuria	13.70	12.22	24	26765	11407	46647866
Histoplasmosis cutaneous	13.43	12.22	3	26786	19	46659254
Mycoplasma infection	13.41	12.22	6	26783	423	46658850
Hyperuricaemia	13.39	12.22	15	26774	4702	46654571
Bacteroides bacteraemia	13.17	12.22	3	26786	21	46659252
Urinary tract infection bacterial	13.14	12.22	14	26775	4151	46655122
Pneumonia	13.09	12.22	295	26494	376025	46283248
Bacterial sepsis	13.08	12.22	13	26776	3554	46655719
Neuroendocrine carcinoma of the skin	13.08	12.22	6	26783	448	46658825
Angiosarcoma	12.84	12.22	5	26784	248	46659025
Therapy cessation	12.83	12.22	39	26750	26590	46632683
Sterile pyuria	12.81	12.22	3	26786	24	46659249
Typhoid fever	12.81	12.22	3	26786	24	46659249
Bone marrow granuloma	12.81	12.22	3	26786	24	46659249
Neutropenia	12.79	12.22	132	26657	143072	46516201
Normocytic anaemia	12.69	12.22	8	26781	1131	46658142
Suicide attempt	12.61	12.22	8	26781	55028	46604245
Genital herpes	12.57	12.22	9	26780	1570	46657703
Renal haemorrhage	12.48	12.22	7	26782	799	46658474
Necrotising fasciitis	12.39	12.22	11	26778	2612	46656661
Femur fracture	12.37	12.22	3	26786	36994	46622279
Extremity necrosis	12.30	12.22	9	26780	1624	46657649
Epstein-Barr virus antibody positive	12.25	12.22	5	26784	281	46658992

FDA Adverse Event Reporting System (Male)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Kidney transplant rejection	680.90	13.10	269	32229	7240	29912740
Cytomegalovirus infection	521.79	13.10	323	32175	23351	29896629
Transplant rejection	486.50	13.10	225	32273	8981	29910999
Complications of transplanted kidney	425.19	13.10	162	32336	3939	29916041
COVID-19	353.91	13.10	228	32270	17650	29902330
Polyomavirus-associated nephropathy	312.92	13.10	121	32377	3064	29916916
BK virus infection	234.63	13.10	108	32390	4256	29915724
Immunosuppressant drug level increased	230.00	13.10	109	32389	4593	29915387
Transplant dysfunction	229.78	13.10	89	32409	2263	29917717
Post transplant lymphoproliferative disorder	220.43	13.10	110	32388	5196	29914784
Blood creatinine increased	204.44	13.10	360	32138	91015	29828965
Hepatitis E	185.57	13.10	69	32429	1563	29918417
Renal transplant failure	178.98	13.10	60	32438	991	29918989
Product use in unapproved indication	161.69	13.10	288	32210	73405	29846575
Thrombotic microangiopathy	153.70	13.10	103	32395	8507	29911473
JC virus infection	151.27	13.10	61	32437	1729	29918251
Nephropathy toxic	138.50	13.10	105	32393	10534	29909446
West Nile viral infection	129.47	13.10	41	32457	560	29919420
Transplant failure	122.30	13.10	58	32440	2446	29917534
Cytomegalovirus viraemia	120.57	13.10	76	32422	5653	29914327
Aspergillus infection	120.30	13.10	95	32403	10119	29909861
Leukopenia	118.66	13.10	216	32282	55943	29864037
Delayed graft function	115.50	13.10	50	32448	1699	29918281
Incision site pain	115.29	13.10	52	32446	1952	29918028
Epstein-Barr virus infection	114.38	13.10	78	32420	6628	29913352
Mucormycosis	108.65	13.10	69	32429	5199	29914781
Renal tubular atrophy	106.62	13.10	41	32457	1021	29918959
Kidney fibrosis	104.00	13.10	49	32449	2036	29917944
Drug level increased	96.33	13.10	109	32389	18245	29901735
Cryptococcosis	94.99	13.10	44	32454	1758	29918222
Chronic allograft nephropathy	89.19	13.10	37	32461	1129	29918851
Phaeohyphomycosis	87.23	13.10	33	32465	785	29919195
Lymphocyte count decreased	86.42	13.10	105	32393	18950	29901030
Nocardiosis	85.92	13.10	51	32447	3404	29916576
Proteinuria	83.23	13.10	95	32403	16050	29903930
Apoptosis	82.73	13.10	23	32475	193	29919787
Bronchopulmonary aspergillosis	80.38	13.10	82	32416	12202	29907778
Strongyloidiasis	78.31	13.10	42	32456	2304	29917676
Fall	77.65	13.10	51	32447	181821	29738159
Klebsiella infection	76.71	13.10	62	32436	6825	29913155
Histoplasmosis	73.30	13.10	33	32465	1233	29918747
COVID-19 pneumonia	70.83	13.10	50	32448	4490	29915490
Cystitis haemorrhagic	70.73	13.10	51	32447	4736	29915244
Off label use	70.01	13.10	486	32012	248804	29671176
Focal segmental glomerulosclerosis	67.49	13.10	35	32463	1792	29918188
Blastomycosis	67.26	13.10	21	32477	273	29919707
Liver transplant rejection	66.85	13.10	37	32461	2161	29917819
Lymphocele	65.78	13.10	32	32466	1428	29918552
Fatigue	65.76	13.10	158	32340	320515	29599465
Pneumonia cryptococcal	65.71	13.10	26	32472	700	29919280
Rash	65.54	13.10	67	32431	191822	29728158
Graft loss	64.50	13.10	27	32471	843	29919137
Acute kidney injury	64.47	13.10	512	31986	273330	29646650
Progressive multifocal leukoencephalopathy	64.19	13.10	63	32435	8950	29911030
Red blood cells urine positive	62.68	13.10	32	32466	1585	29918395
Encephalitis viral	62.31	13.10	29	32469	1171	29918809
Enterococcal infection	61.41	13.10	59	32439	8165	29911815
Parvovirus B19 infection	60.80	13.10	23	32475	547	29919433
Posterior reversible encephalopathy syndrome	58.56	13.10	59	32439	8648	29911332
Graft versus host disease in skin	57.66	13.10	39	32459	3268	29916712
Acinetobacter infection	57.44	13.10	26	32472	984	29918996
Urinary tract infection	57.28	13.10	193	32305	73466	29846514
Diabetes mellitus	56.51	13.10	134	32364	41731	29878249
Cytomegalovirus colitis	56.25	13.10	34	32464	2345	29917635
Scedosporium infection	55.74	13.10	23	32475	692	29919288
Adenovirus infection	55.26	13.10	42	32456	4226	29915754
Malacoplakia	55.03	13.10	15	32483	116	29919864
Neutrophil count increased	54.67	13.10	75	32423	15248	29904732
Pseudomonas infection	54.56	13.10	62	32436	10420	29909560
Dizziness	53.01	13.10	81	32417	194828	29725152
Graft versus host disease	52.77	13.10	60	32438	10090	29909890
Renal impairment	52.27	13.10	205	32293	83979	29836001
Graft versus host disease in lung	52.23	13.10	20	32478	492	29919488
Renal tubular necrosis	51.95	13.10	73	32425	15178	29904802
Septic shock	51.53	13.10	169	32329	63438	29856542
Disseminated cryptococcosis	51.20	13.10	24	32474	985	29918995
Graft versus host disease in gastrointestinal tract	50.68	13.10	35	32463	3034	29916946
Hydronephrosis	49.95	13.10	55	32443	8928	29911052
Ureteric stenosis	49.58	13.10	25	32473	1206	29918774
Protein urine present	49.01	13.10	41	32457	4734	29915246
Pneumonia cytomegaloviral	48.81	13.10	33	32465	2763	29917217
Renal artery stenosis	47.97	13.10	28	32470	1811	29918169
Pruritus	46.64	13.10	36	32462	118168	29801812
Depression	46.41	13.10	20	32478	90417	29829563
Infection reactivation	46.33	13.10	22	32476	930	29919050
Acanthamoeba infection	46.04	13.10	18	32480	469	29919511
Malignant neoplasm progression	45.89	13.10	11	32487	72276	29847704
Pulmonary nocardiosis	45.84	13.10	17	32481	382	29919598
Pneumocystis jirovecii pneumonia	45.53	13.10	73	32425	17047	29902933
Pain	44.79	13.10	74	32424	172567	29747413
Alternaria infection	41.98	13.10	15	32483	302	29919678
Acute graft versus host disease	41.77	13.10	41	32457	5823	29914157
Polyomavirus viraemia	41.72	13.10	17	32481	495	29919485
Blood urea increased	40.78	13.10	99	32399	31282	29888698
Escherichia infection	40.53	13.10	42	32456	6363	29913617
Anxiety	39.95	13.10	24	32474	89847	29830133
Chronic graft versus host disease in skin	39.26	13.10	18	32480	702	29919278
Histology abnormal	38.99	13.10	14	32484	286	29919694
Trichodysplasia spinulosa	38.81	13.10	13	32485	214	29919766
Brain abscess	38.32	13.10	28	32470	2653	29917327
Chronic graft versus host disease	37.46	13.10	33	32465	4086	29915894
Pancreas transplant rejection	37.36	13.10	12	32486	172	29919808
Cryptosporidiosis infection	37.12	13.10	14	32484	330	29919650
Mycobacterial infection	36.63	13.10	23	32475	1698	29918282
Chronic graft versus host disease in liver	36.23	13.10	13	32485	265	29919715
Acute respiratory distress syndrome	35.95	13.10	79	32419	23393	29896587
Coronavirus infection	35.83	13.10	30	32468	3468	29916512
Renal transplant	35.82	13.10	23	32475	1765	29918215
Pyelonephritis acute	35.70	13.10	22	32476	1571	29918409
Constipation	35.64	13.10	42	32456	112864	29807116
Urinoma	35.20	13.10	12	32486	209	29919771
Smooth muscle cell neoplasm	34.96	13.10	10	32488	94	29919886
Syncope	34.58	13.10	25	32473	84878	29835102
Graft versus host disease in liver	33.61	13.10	18	32480	984	29918996
Viraemia	33.55	13.10	19	32479	1160	29918820
Pyelonephritis	33.29	13.10	35	32463	5391	29914589
Basal cell carcinoma	32.86	13.10	61	32437	16007	29903973
Gastroenteritis norovirus	32.66	13.10	20	32478	1412	29918568
Hyperhidrosis	32.60	13.10	16	32482	67074	29852906
Myocardial infarction	32.41	13.10	54	32444	125571	29794409
Drug hypersensitivity	32.31	13.10	17	32481	68502	29851478
Varicella zoster virus infection	32.26	13.10	19	32479	1249	29918731
Squamous cell carcinoma	31.88	13.10	47	32451	10203	29909777
American trypanosomiasis	31.83	13.10	11	32487	200	29919780
Escherichia urinary tract infection	31.81	13.10	26	32472	2906	29917074
Somnolence	31.62	13.10	35	32463	96728	29823252
Dyspnoea	31.61	13.10	222	32276	333073	29586907
Chronic obstructive pulmonary disease	31.35	13.10	6	32492	46120	29873860
Arthralgia	30.92	13.10	63	32435	135728	29784252
Lymphopenia	30.80	13.10	53	32445	13110	29906870
Haemophagocytic lymphohistiocytosis	30.61	13.10	45	32453	9746	29910234
Donor specific antibody present	30.53	13.10	9	32489	95	29919885
Pneumonia escherichia	29.66	13.10	12	32486	343	29919637
Rhodococcus infection	29.50	13.10	10	32488	171	29919809
Papilloma viral infection	28.96	13.10	12	32486	365	29919615
Meningoencephalitis amoebic	28.41	13.10	9	32489	123	29919857
Decreased appetite	28.18	13.10	77	32421	149833	29770147
Trichophytosis	27.84	13.10	11	32487	295	29919685
Ventricular remodelling	27.80	13.10	8	32490	77	29919903
Necrotising oesophagitis	27.60	13.10	12	32486	412	29919568
Immune reconstitution inflammatory syndrome	27.26	13.10	41	32457	9060	29910920
Immunosuppressant drug level decreased	27.23	13.10	17	32481	1242	29918738
Cardiac failure congestive	27.06	13.10	31	32467	84376	29835604
Human herpesvirus 6 infection	26.97	13.10	20	32478	1938	29918042
Dermatophytosis	26.95	13.10	10	32488	225	29919755
Diarrhoea	26.95	13.10	510	31988	333593	29586387
Epstein-Barr virus associated lymphoproliferative disorder	26.88	13.10	19	32479	1709	29918271
Meningitis cryptococcal	26.38	13.10	20	32478	2004	29917976
Cerebral aspergillosis	26.05	13.10	17	32481	1341	29918639
Renal tubular injury	25.98	13.10	13	32485	617	29919363
Neuropathy peripheral	25.88	13.10	23	32475	70452	29849528
Non-cirrhotic portal hypertension	25.78	13.10	10	32488	255	29919725
Perinephric collection	25.57	13.10	9	32489	173	29919807
Aplasia pure red cell	25.49	13.10	31	32467	5595	29914385
Anogenital warts	25.41	13.10	12	32486	501	29919479
Mycobacterium haemophilum infection	25.33	13.10	6	32492	24	29919956
Epistaxis	25.19	13.10	13	32485	52968	29867012
Respiratory failure	25.09	13.10	191	32307	100451	29819529
Candida infection	25	13.10	53	32445	15309	29904671
Heart transplant rejection	24.81	13.10	16	32482	1237	29918743
Rheumatoid arthritis	24.74	13.10	7	32491	41190	29878790
Malaise	24.31	13.10	96	32402	166866	29753114
Nausea	24.26	13.10	206	32292	296751	29623229
Hernial eventration	24.08	13.10	7	32491	70	29919910
Coronary artery disease	23.93	13.10	12	32486	49700	29870280
Tubulointerstitial nephritis	23.83	13.10	57	32441	17834	29902146
Glomerulonephritis	23.82	13.10	18	32480	1795	29918185
Pneumocystis jirovecii infection	23.78	13.10	16	32482	1329	29918651
Encephalitis	23.71	13.10	32	32466	6404	29913576
Acute myocardial infarction	23.70	13.10	14	32484	52925	29867055
Nasal cavity cancer	23.64	13.10	8	32490	136	29919844
Wrong technique in product usage process	23.55	13.10	3	32495	31152	29888828
Nephrotic syndrome	23.51	13.10	33	32465	6852	29913128
Renal vein thrombosis	23.43	13.10	8	32490	140	29919840
Necrotising fasciitis fungal	23.33	13.10	5	32493	11	29919969
Vesicoureteral reflux surgery	23.31	13.10	4	32494	0	29919980
Seroma	23.23	13.10	12	32486	609	29919371
Erythema	23.18	13.10	30	32468	77421	29842559
Cholangitis	23.16	13.10	35	32463	7767	29912213
Disseminated varicella zoster virus infection	23.10	13.10	14	32484	970	29919010
Diffuse large B-cell lymphoma	23.02	13.10	35	32463	7806	29912174
Intentional product misuse	22.54	13.10	5	32493	34662	29885318
Isosporiasis	22.42	13.10	7	32491	91	29919889
Renal graft infection	22.41	13.10	9	32489	252	29919728
Insomnia	22.36	13.10	42	32456	93294	29826686
Cutaneous malacoplakia	22.29	13.10	6	32492	44	29919936
Hyperkalaemia	22.26	13.10	135	32363	65875	29854105
Fungal infection	22.22	13.10	47	32451	13553	29906427
Urinary tract infection bacterial	22.20	13.10	16	32482	1484	29918496
Transplantation complication	22.07	13.10	7	32491	96	29919884
Asthma	22.00	13.10	6	32492	36168	29883812
Glomerulonephritis membranoproliferative	21.91	13.10	10	32488	386	29919594
Hypersensitivity	21.87	13.10	16	32482	54012	29865968
Histoplasmosis cutaneous	21.75	13.10	5	32493	17	29919963
Renal tubular acidosis	21.56	13.10	17	32481	1805	29918175
Intra-abdominal haemorrhage	21.47	13.10	18	32480	2084	29917896
Plasma cell myeloma	21.43	13.10	16	32482	53446	29866534
Procedural pain	21.30	13.10	27	32471	5082	29914898
Drug interaction	21.29	13.10	319	32179	199249	29720731
Myopathy toxic	21.25	13.10	10	32488	414	29919566
Alveolar proteinosis	21.23	13.10	9	32489	290	29919690
Bacterial infection	21.09	13.10	44	32454	12566	29907414
Urticaria	21.05	13.10	17	32481	54589	29865391
Disease recurrence	20.93	13.10	47	32451	14114	29905866
Neurotoxicity	20.90	13.10	45	32453	13137	29906843
IgA nephropathy	20.83	13.10	13	32485	949	29919031
Neutrophil count decreased	20.81	13.10	10	32488	42444	29877536
Loss of consciousness	20.56	13.10	34	32464	79341	29840639
Large intestinal ulcer	20.53	13.10	16	32482	1670	29918310
Seizure	20.49	13.10	48	32450	98427	29821553
Bacterial sepsis	20.48	13.10	26	32472	4900	29915080
Gastroenteritis sapovirus	20.47	13.10	7	32491	123	29919857
Parvovirus infection	20.23	13.10	10	32488	462	29919518
End stage renal disease	20.17	13.10	32	32466	7403	29912577
Infected lymphocele	19.89	13.10	5	32493	27	29919953
Urosepsis	19.80	13.10	39	32459	10693	29909287
Chronic graft versus host disease in intestine	19.66	13.10	8	32490	232	29919748
Cardio-respiratory arrest	19.52	13.10	20	32478	57286	29862694
Death	19.49	13.10	272	32226	357011	29562969
Delusion of grandeur	19.44	13.10	9	32489	359	29919621
Complications of transplanted heart	19.41	13.10	8	32490	240	29919740
Acute graft versus host disease in intestine	19.38	13.10	18	32480	2387	29917593
Scleroderma	19.29	13.10	14	32484	1313	29918667
Herpes zoster oticus	19.29	13.10	6	32492	77	29919903
Asthenia	19.19	13.10	151	32347	221139	29698841
Febrile neutropenia	19.15	13.10	56	32442	106637	29813343
Optic discs blurred	19.08	13.10	6	32492	80	29919900
Blood creatine phosphokinase increased	19.07	13.10	12	32486	43836	29876144
Hemianopia heteronymous	19.03	13.10	5	32493	33	29919947
Blood pressure decreased	18.98	13.10	14	32484	47061	29872919
Eccrine squamous syringometaplasia	18.90	13.10	5	32493	34	29919946
Bacterial pyelonephritis	18.67	13.10	8	32490	265	29919715
Cardiac disorder	18.65	13.10	10	32488	39883	29880097
Suicidal ideation	18.49	13.10	8	32490	36106	29883874
Post procedural urine leak	18.48	13.10	7	32491	167	29919813
Retinal artery occlusion	18.41	13.10	15	32483	1669	29918311
Haemoglobinaemia	18.33	13.10	7	32491	171	29919809
Myocardial strain	18.25	13.10	6	32492	93	29919887
International normalised ratio increased	18.23	13.10	15	32483	47724	29872256
Haemolytic uraemic syndrome	18.13	13.10	16	32482	1986	29917994
Anorectal varices	18.09	13.10	5	32493	41	29919939
Feeling abnormal	18.01	13.10	21	32477	56735	29863245
Cardiac failure	17.89	13.10	40	32458	83378	29836602
Enterobacter infection	17.69	13.10	16	32482	2050	29917930
Pemphigus	17.64	13.10	13	32485	1248	29918732
Joint swelling	17.62	13.10	15	32483	46931	29873049
Muscle spasms	17.52	13.10	27	32471	64811	29855169
Chest pain	17.51	13.10	67	32431	117560	29802420
Ureteral catheterisation	17.48	13.10	3	32495	0	29919980
Acute graft versus host disease in skin	17.47	13.10	23	32475	4493	29915487
Suicide attempt	17.45	13.10	9	32489	36688	29883292
Paraesthesia	17.35	13.10	20	32478	54307	29865673
Hypotension	17.32	13.10	137	32361	200428	29719552
Fungal skin infection	17.31	13.10	17	32481	2415	29917565
Leishmaniasis	17.28	13.10	8	32490	319	29919661
Anti-erythropoietin antibody negative	17.27	13.10	7	32491	201	29919779
Systemic candida	17.26	13.10	18	32480	2746	29917234
Human polyomavirus infection	17.23	13.10	10	32488	640	29919340
Hypoglycaemia	17.13	13.10	18	32480	50963	29869017
Inappropriate schedule of product administration	17.10	13.10	11	32487	39717	29880263
Renal cancer stage I	17.09	13.10	4	32494	15	29919965
Liver transplant	17.06	13.10	18	32480	2784	29917196
Pneumonia pseudomonal	16.95	13.10	20	32478	3498	29916482
Superinfection bacterial	16.89	13.10	9	32489	487	29919493
Cytomegalovirus nephritis	16.87	13.10	6	32492	119	29919861
Secondary immunodeficiency	16.85	13.10	8	32490	338	29919642
Hallucination	16.85	13.10	17	32481	49042	29870938
Glomerulonephritis proliferative	16.83	13.10	7	32491	215	29919765
Biliary anastomosis complication	16.83	13.10	6	32492	120	29919860
Drug reaction with eosinophilia and systemic symptoms	16.81	13.10	5	32493	28483	29891497
Platelet count decreased	16.75	13.10	59	32439	106070	29813910
Lung transplant	16.73	13.10	15	32483	1901	29918079
Incisional hernia	16.72	13.10	12	32486	1106	29918874
Human herpesvirus 8 infection	16.68	13.10	10	32488	679	29919301
Nephrostomy	16.56	13.10	7	32491	224	29919756
Argentine haemorrhagic fever	16.51	13.10	4	32494	18	29919962
Renal lymphocele	16.45	13.10	5	32493	59	29919921
Urinary fistula	16.38	13.10	6	32492	130	29919850
Hypogammaglobulinaemia	16.21	13.10	24	32474	5228	29914752
Back pain	16.21	13.10	57	32441	102539	29817441
Postoperative wound infection	16.18	13.10	22	32476	4433	29915547
Epstein-Barr virus associated lymphoma	16.02	13.10	9	32489	541	29919439
Periostitis	15.95	13.10	7	32491	246	29919734
Chronic kidney disease-mineral and bone disorder	15.94	13.10	8	32490	382	29919598
Functional gastrointestinal disorder	15.93	13.10	15	32483	2024	29917956
Depressed level of consciousness	15.89	13.10	11	32487	38211	29881769
Product dose omission issue	15.79	13.10	49	32449	91582	29828398
Respiratory arrest	15.76	13.10	6	32492	29252	29890728
Metastatic squamous cell carcinoma	15.71	13.10	8	32490	394	29919586
Propionibacterium infection	15.66	13.10	7	32491	257	29919723
Pyrexia	15.65	13.10	424	32074	294065	29625915
Lung transplant rejection	15.64	13.10	10	32488	762	29919218
Metabolic acidosis	15.53	13.10	81	32417	37380	29882600
Angioedema	15.52	13.10	9	32489	34375	29885605
Enterovirus infection	15.46	13.10	9	32489	579	29919401
Cranial nerve paralysis	15.41	13.10	4	32494	25	29919955
Balamuthia infection	15.41	13.10	3	32495	3	29919977
Musculoskeletal stiffness	15.35	13.10	10	32488	35871	29884109
Electrocardiogram QT prolonged	15.31	13.10	10	32488	35825	29884155
Dysgeusia	15.29	13.10	4	32494	24797	29895183
Mycobacterium chelonae infection	15.22	13.10	9	32489	596	29919384
Creatinine urine increased	15.18	13.10	6	32492	161	29919819
Urine output decreased	15.18	13.10	33	32465	9696	29910284
Malacoplakia gastrointestinal	15.12	13.10	5	32493	79	29919901
Peripheral swelling	15.05	13.10	27	32471	61047	29858933
Multiple organ dysfunction syndrome	14.98	13.10	119	32379	63368	29856612
Catatonia	14.96	13.10	21	32477	4359	29915621
Leuconostoc infection	14.94	13.10	3	32495	4	29919976
Aggression	14.84	13.10	11	32487	36896	29883084
Foetal exposure during pregnancy	14.82	13.10	11	32487	36860	29883120
Lymphorrhoea	14.78	13.10	5	32493	85	29919895
Herpes zoster cutaneous disseminated	14.75	13.10	6	32492	174	29919806
Stenotrophomonas infection	14.74	13.10	13	32485	1611	29918369
Gingival hypertrophy	14.68	13.10	13	32485	1620	29918360
Drug level fluctuating	14.60	13.10	8	32490	458	29919522
Prophylaxis against transplant rejection	14.56	13.10	4	32494	32	29919948
Central nervous system lesion	14.55	13.10	22	32476	4884	29915096
Arteriovenous fistula aneurysm	14.55	13.10	3	32495	5	29919975
Pyuria	14.54	13.10	9	32489	648	29919332
Hospitalisation	14.53	13.10	90	32408	44229	29875751
Spindle cell sarcoma	14.46	13.10	5	32493	91	29919889
Epidermodysplasia verruciformis	14.45	13.10	4	32494	33	29919947
Herpes simplex hepatitis	14.41	13.10	5	32493	92	29919888
Staphylococcal infection	14.40	13.10	68	32430	30156	29889824
Injury	14.40	13.10	3	32495	21728	29898252
Mouth ulceration	14.34	13.10	34	32464	10575	29909405
Abdominal wall abscess	14.15	13.10	8	32490	487	29919493
Brain compression	14.14	13.10	6	32492	194	29919786
Visceral leishmaniasis	14.13	13.10	8	32490	488	29919492
Cerebrovascular accident	14.13	13.10	45	32453	83432	29836548
Gastroenteritis cryptosporidial	14.11	13.10	6	32492	195	29919785
Epstein-Barr viraemia	14.08	13.10	10	32488	906	29919074
Chronic hepatitis C	14.07	13.10	8	32490	492	29919488
Pancreas transplant	13.95	13.10	4	32494	38	29919942
Pain in extremity	13.81	13.10	67	32431	110154	29809826
Cytomegalovirus gastroenteritis	13.75	13.10	6	32492	208	29919772
Skin necrosis	13.74	13.10	21	32477	4706	29915274
White blood cell count decreased	13.69	13.10	46	32452	83901	29836079
Cutaneous mucormycosis	13.67	13.10	4	32494	41	29919939
Intestine transplant rejection	13.67	13.10	4	32494	41	29919939
Biopsy kidney abnormal	13.66	13.10	5	32493	108	29919872
Histoplasmosis disseminated	13.62	13.10	10	32488	954	29919026
Acinetobacter bacteraemia	13.62	13.10	5	32493	109	29919871
Endocarditis viral	13.59	13.10	3	32495	8	29919972
Meningoencephalitis viral	13.54	13.10	5	32493	111	29919869
Cytomegalovirus mucocutaneous ulcer	13.42	13.10	4	32494	44	29919936
Nodular regenerative hyperplasia	13.40	13.10	9	32489	745	29919235
Cytomegalovirus syndrome	13.37	13.10	5	32493	115	29919865
Low density lipoprotein increased	13.34	13.10	19	32479	3997	29915983
Herpes zoster	13.29	13.10	66	32432	29877	29890103
Balance disorder	13.28	13.10	12	32486	36481	29883499
Ureteric anastomosis complication	13.18	13.10	4	32494	47	29919933
Oesophageal ulcer	13.16	13.10	17	32481	3260	29916720

Pharmacologic Action:

Source	Code	Description
ATC	L04AA06	ANTINEOPLASTIC AND IMMUNOMODULATING AGENTS IMMUNOSUPPRESSANTS IMMUNOSUPPRESSANTS Selective immunosuppressants
FDA EPC	N0000175613	Antimetabolite Immunosuppressant
MeSH PA	D000900	Anti-Bacterial Agents
MeSH PA	D000890	Anti-Infective Agents
MeSH PA	D000903	Antibiotics, Antineoplastic
MeSH PA	D000904	Antibiotics, Antitubercular
MeSH PA	D000970	Antineoplastic Agents
MeSH PA	D000995	Antitubercular Agents
MeSH PA	D004791	Enzyme Inhibitors
CHEBI has role	CHEBI:35705	immunosuppressant
CHEBI has role	CHEBI:53746	imp dehydrogenase (ec 1.1.1.205) inhibitor
CHEBI has role	CHEBI:25442	mycotoxins
CHEBI has role	CHEBI:33281	antibiotics
CHEBI has role	CHEBI:35610	cytostatic
CHEBI has role	CHEBI:35703	xenobiotic
CHEBI has role	CHEBI:76964	penicillium metabolites
CHEBI has role	CHEBI:78298	environmental contaminants
CHEBI has role	CHEBI:149553	anti-coronaviral agents

Drug Use (View source of the data)

Disease	Relation	SNOMED_ID	DOID
Prevention of Liver Transplant Rejection	indication
Prevention of Cardiac Transplant Rejection	indication
Prevention of Kidney Transplant Rejection	indication
Prevention of Lung Transplant Rejection	off-label use
Herpes zoster	contraindication	4740000	DOID:8536
Progressive multifocal leukoencephalopathy	contraindication	22255007	DOID:643
Cytomegalovirus infection	contraindication	28944009
Constitutional aplastic anemia	contraindication	28975000	DOID:1342
Gastrointestinal ulcer	contraindication	40845000
Gastrointestinal perforation	contraindication	51875005
Acute nephropathy	contraindication	58574008
Acute infectious disease	contraindication	63171007
Gastrointestinal hemorrhage	contraindication	74474003
Herpes simplex	contraindication	88594005	DOID:8566
Malignant lymphoma	contraindication	118600007	DOID:0060058
Deficiency of hypoxanthine phosphoribosyltransferase	contraindication	124275001
Disease of liver	contraindication	235856003	DOID:409
Pregnancy, function	contraindication	289908002
Neutropenic disorder	contraindication	303011007	DOID:1227
Bone marrow depression	contraindication	307762000
Primary malignant neoplasm	contraindication	372087000
Malignant neoplasm of skin	contraindication	372130007	DOID:4159
Breastfeeding (mother)	contraindication	413712001
Opportunistic Fungal Infection	contraindication
BK Polyomavirus Reactivation Nephropathy	contraindication

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation level	Dissociation constant	Type (acidic/basic)
pKa1	4.67	acidic
pKa2	11.03	acidic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

Target	Class	Pharos	UniProt	Action	Type	Activity value (-log[M])	Mechanism action	Bioact source	MoA source
Inosine-5'-monophosphate dehydrogenase (IMPDH)	Enzyme	P12268 P20839	IMDH1_HUMAN IMDH2_HUMAN	INHIBITOR	IC50	4.70		CHEMBL	CHEMBL
Inosine-5'-monophosphate dehydrogenase 2	Enzyme	P12268	IMDH2_HUMAN		Ki	8.22		CHEMBL
Inosine-5'-monophosphate dehydrogenase 1	Enzyme	P20839	IMDH1_HUMAN		Ki	7.48		CHEMBL

External reference:

ID	Source
4025608	VUID
N0000176078	NUI
D05095	KEGG_DRUG
24280-93-1	SECONDARY_CAS_RN
4021418	VANDF
4025598	VANDF
4025608	VANDF
C0883242	UMLSCUI
CHEBI:168396	CHEBI
MOA	PDB_CHEM_ID
CHEMBL2106643	ChEMBL_ID
CHEMBL866	ChEMBL_ID
D009173	MESH_DESCRIPTOR_UI
DB01024	DRUGBANK_ID
6832	IUPHAR_LIGAND_ID
2950	INN_ID
WX877SQI1G	UNII
446541	PUBCHEM_CID
265323	RXNORM
18132	MMSL
210716	MMSL
d05217	MMSL
005013	NDDF
009984	NDDF
409330005	SNOMEDCT_US
409331009	SNOMEDCT_US
426216009	SNOMEDCT_US

Pharmaceutical products:

Product	Category	Ingredients	NDC	Form	Quantity	Route	Marketing	Label
Myfortic	HUMAN PRESCRIPTION DRUG LABEL	1	0078-0385	TABLET, DELAYED RELEASE	180 mg	ORAL	NDA	29 sections
Myfortic	HUMAN PRESCRIPTION DRUG LABEL	1	0078-0386	TABLET, DELAYED RELEASE	360 mg	ORAL	NDA	29 sections
Mycophenolic Acid	HUMAN PRESCRIPTION DRUG LABEL	1	0378-4201	TABLET, DELAYED RELEASE	180 mg	ORAL	ANDA	29 sections
Mycophenolic Acid	HUMAN PRESCRIPTION DRUG LABEL	1	0378-4202	TABLET, DELAYED RELEASE	360 mg	ORAL	ANDA	29 sections
Mycophenolic Acid	HUMAN PRESCRIPTION DRUG LABEL	1	0904-6785	TABLET, DELAYED RELEASE	180 mg	ORAL	ANDA	20 sections
Mycophenolic Acid	HUMAN PRESCRIPTION DRUG LABEL	1	0904-6786	TABLET, DELAYED RELEASE	360 mg	ORAL	ANDA	20 sections
Mycophenolic Acid	HUMAN PRESCRIPTION DRUG LABEL	1	16729-189	TABLET, DELAYED RELEASE	360 mg	ORAL	ANDA	27 sections
Mycophenolic Acid	HUMAN PRESCRIPTION DRUG LABEL	1	16729-261	TABLET, DELAYED RELEASE	180 mg	ORAL	ANDA	27 sections
Mycophenolic Acid	HUMAN PRESCRIPTION DRUG LABEL	1	50268-559	TABLET, DELAYED RELEASE	180 mg	ORAL	ANDA	23 sections
Mycophenolic Acid	HUMAN PRESCRIPTION DRUG LABEL	1	50268-560	TABLET, DELAYED RELEASE	360 mg	ORAL	ANDA	23 sections
Mycophenolic Acid	HUMAN PRESCRIPTION DRUG LABEL	1	51079-508	TABLET, DELAYED RELEASE	180 mg	ORAL	ANDA	28 sections
Mycophenolic Acid	HUMAN PRESCRIPTION DRUG LABEL	1	51079-509	TABLET, DELAYED RELEASE	360 mg	ORAL	ANDA	28 sections
Mycophenolic Acid	HUMAN PRESCRIPTION DRUG LABEL	1	60429-016	TABLET, DELAYED RELEASE	180 mg	ORAL	ANDA	23 sections
Mycophenolic Acid	HUMAN PRESCRIPTION DRUG LABEL	1	60429-017	TABLET, DELAYED RELEASE	360 mg	ORAL	ANDA	23 sections
Mycophenolic Acid	HUMAN PRESCRIPTION DRUG LABEL	1	60505-2965	TABLET, DELAYED RELEASE	180 mg	ORAL	ANDA	23 sections
Mycophenolic Acid	HUMAN PRESCRIPTION DRUG LABEL	1	60505-2966	TABLET, DELAYED RELEASE	360 mg	ORAL	ANDA	23 sections
Mycophenolic Acid	HUMAN PRESCRIPTION DRUG LABEL	1	68084-907	TABLET, DELAYED RELEASE	180 mg	ORAL	ANDA	20 sections
Mycophenolic Acid	HUMAN PRESCRIPTION DRUG LABEL	1	68084-918	TABLET, DELAYED RELEASE	360 mg	ORAL	ANDA	20 sections
mycophenolic acid	HUMAN PRESCRIPTION DRUG LABEL	1	68254-5001	TABLET, DELAYED RELEASE	180 mg	ORAL	ANDA	26 sections
mycophenolic acid	HUMAN PRESCRIPTION DRUG LABEL	1	68254-5002	TABLET, DELAYED RELEASE	360 mg	ORAL	ANDA	26 sections
Mycophenolic Acid	HUMAN PRESCRIPTION DRUG LABEL	1	70436-172	TABLET, DELAYED RELEASE	180 mg	ORAL	ANDA	29 sections
Mycophenolic Acid	HUMAN PRESCRIPTION DRUG LABEL	1	70436-173	TABLET, DELAYED RELEASE	360 mg	ORAL	ANDA	29 sections
mycophenolic acid	HUMAN PRESCRIPTION DRUG LABEL	1	70748-217	TABLET, DELAYED RELEASE	180 mg	ORAL	ANDA	26 sections
mycophenolic acid	HUMAN PRESCRIPTION DRUG LABEL	1	70748-218	TABLET, DELAYED RELEASE	360 mg	ORAL	ANDA	26 sections