carvedilol ๐Ÿถ Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
vasodilators 522 72956-09-3

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • carvedilol
  • carvedilol phosphate
  • carvediol
  • carvedilol hydrochloride
  • carvedilol HCl
  • BM 14,190
A carbazole and propanol derivative that acts as a non-cardioselective beta blocker and vasodilator. It has blocking activity for ALPHA 1 ADRENERGIC RECEPTORS and, at higher doses, may function as a blocker of CALCIUM CHANNELS; it also has antioxidant properties. Carvedilol is used in the treatment of HYPERTENSION; ANGINA PECTORIS; and HEART FAILURE. It can also reduce the risk of death following MYOCARDIAL INFARCTION.
  • Molecular weight: 406.48
  • Formula: C24H26N2O4
  • CLOGP: 4.04
  • LIPINSKI: 0
  • HAC: 6
  • HDO: 3
  • TPSA: 75.74
  • ALOGS: -4.96
  • ROTB: 10

  • Status: OFP

  • Legend:
    OFP - off patent
    OFM - off market
    ONP - on patent

Drug dosage:

DoseUnitRoute
37.50 mg O

ADMET properties:

PropertyValueReference
BDDCS (Biopharmaceutical Drug Disposition Classification System) 2 Benet LZ, Broccatelli F, Oprea TI
S (Water solubility) 0.01 mg/mL Benet LZ, Broccatelli F, Oprea TI
EoM (Fraction excreted unchanged in urine) 1 % Benet LZ, Broccatelli F, Oprea TI
MRTD (Maximum Recommended Therapeutic Daily Dose) 1.03 ยตM/kg/day Contrera JF, Matthews EJ, Kruhlak NL, Benz RD
Vd (Volume of distribution) 1.30 L/kg Lombardo F, Berellini G, Obach RS
CL (Clearance) 7.80 mL/min/kg Lombardo F, Berellini G, Obach RS
fu (Fraction unbound in plasma) 0.02 % Lombardo F, Berellini G, Obach RS
t_half (Half-life) 2.40 hours Lombardo F, Berellini G, Obach RS

Approvals:

DateAgencyCompanyOrphan
Sept. 14, 1995 FDA SMITHKLINE BEECHAM

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Cardiac failure congestive 1150.09 10.03 1046 87903 83336 50432839
Myocardial infarction 384.40 10.03 615 88334 88412 50427763
Cardiac failure 291.44 10.03 498 88451 75542 50440633
Hypotension 275.23 10.03 974 87975 234495 50281680
Drug ineffective 269.43 10.03 659 88290 818674 49697501
Bradycardia 227.40 10.03 407 88542 64019 50452156
Acute myocardial infarction 169.04 10.03 232 88717 29041 50487134
Synovitis 165.53 10.03 14 88935 123851 50392324
Treatment failure 165.07 10.03 23 88926 137614 50378561
Hyperkalaemia 158.50 10.03 295 88654 47794 50468381
Systemic lupus erythematosus 158.46 10.03 28 88921 140594 50375581
Joint swelling 158.21 10.03 120 88829 245166 50271009
Acute kidney injury 155.26 10.03 801 88148 227257 50288918
Infusion related reaction 150.42 10.03 55 88894 169502 50346673
Rheumatoid arthritis 149.69 10.03 85 88864 202465 50313710
Contraindicated product administered 143.24 10.03 42 88907 148916 50367259
Maternal exposure during pregnancy 141.44 10.03 52 88897 159726 50356449
Cardiomyopathy 139.38 10.03 154 88795 15432 50500743
Hand deformity 137.59 10.03 10 88939 100189 50415986
Glossodynia 136.96 10.03 20 88929 115549 50400626
Gastrointestinal haemorrhage 121.89 10.03 343 88606 72978 50443197
Drug intolerance 119.85 10.03 125 88824 218979 50297196
Chronic kidney disease 117.56 10.03 233 88716 39538 50476637
Ejection fraction decreased 116.41 10.03 153 88796 18367 50497808
Coronary artery disease 115.49 10.03 196 88753 29530 50486645
Lower respiratory tract infection 111.59 10.03 17 88932 95184 50420991
Arthropathy 110.00 10.03 71 88878 157835 50358340
Therapeutic product effect decreased 109.53 10.03 51 88898 135999 50380176
Pain 107.57 10.03 589 88360 578314 49937861
Renal failure 106.61 10.03 420 88529 106213 50409962
Pericarditis 102.14 10.03 10 88939 78679 50437496
Atrial fibrillation 101.11 10.03 400 88549 101345 50414830
Death 99.76 10.03 940 88009 324439 50191736
Hepatic enzyme increased 99.52 10.03 59 88890 137321 50378854
Dyspnoea 97.07 10.03 1423 87526 546185 49969990
Arthralgia 96.02 10.03 421 88528 438281 50077894
Wound 92.63 10.03 35 88914 105759 50410416
Syncope 92.12 10.03 392 88557 102610 50413565
Alopecia 90.57 10.03 184 88765 244863 50271312
Musculoskeletal stiffness 87.80 10.03 59 88890 128422 50387753
Cerebrovascular accident 87.52 10.03 364 88585 94316 50421859
Renal impairment 87.22 10.03 312 88637 75349 50440826
Hypersensitivity 87.02 10.03 153 88796 215008 50301167
Off label use 86.74 10.03 485 88464 473941 50042234
Oedema peripheral 85.53 10.03 522 88427 157439 50358736
International normalised ratio increased 83.93 10.03 214 88735 42938 50473237
Cardiac disorder 78.31 10.03 208 88741 42771 50473404
Hypoglycaemia 76.94 10.03 238 88711 53343 50462832
Chest pain 76.11 10.03 552 88397 176330 50339845
Rash 74.18 10.03 458 88491 437013 50079162
Discomfort 73.73 10.03 50 88899 108330 50407845
Anaemia 72.66 10.03 720 88229 251736 50264439
Hypertensive crisis 69.60 10.03 100 88849 13054 50503121
Helicobacter infection 65.33 10.03 6 88943 49696 50466479
Pulmonary oedema 64.44 10.03 211 88738 48727 50467448
Exposure during pregnancy 63.92 10.03 71 88878 120944 50395231
Dehydration 63.41 10.03 472 88477 151977 50364198
Atrioventricular block 63.15 10.03 67 88882 6411 50509764
Abdominal discomfort 59.68 10.03 208 88741 231433 50284742
Blood glucose increased 59.58 10.03 266 88683 71058 50445117
Blood creatinine increased 59.14 10.03 278 88671 75882 50440293
Mental status changes 57.63 10.03 167 88782 36105 50480070
Congestive cardiomyopathy 57.24 10.03 59 88890 5459 50510716
Folliculitis 56.57 10.03 3 88946 39222 50476953
Cardiomegaly 56.54 10.03 101 88848 15844 50500331
Cardiac arrest 56.18 10.03 293 88656 83358 50432817
Hypervolaemia 55.44 10.03 132 88817 25367 50490808
Cardiogenic shock 54.27 10.03 98 88851 15501 50500674
Fluid retention 54.26 10.03 204 88745 50445 50465730
Blood pressure decreased 53.25 10.03 217 88732 55692 50460483
Product use issue 52.84 10.03 115 88834 149360 50366815
Full blood count decreased 52.22 10.03 119 88830 22227 50493948
Impaired healing 51.89 10.03 29 88920 69757 50446418
Cardioactive drug level increased 51.53 10.03 36 88913 1948 50514227
Haemoglobin decreased 51.26 10.03 391 88558 126825 50389350
Dizziness 51.22 10.03 874 88075 345495 50170680
Infection 50.33 10.03 147 88802 172807 50343368
Cardiac failure chronic 50.01 10.03 45 88904 3518 50512657
Drug abuse 48.81 10.03 22 88927 59824 50456351
Swelling 47.38 10.03 187 88762 200685 50315490
Peritonitis bacterial 46.84 10.03 49 88900 4612 50511563
Drug interaction 45.64 10.03 544 88405 199077 50317098
Asthenia 44.62 10.03 798 88151 318244 50197931
Drug hypersensitivity 44.43 10.03 259 88690 250751 50265424
Glomerular filtration rate decreased 44.15 10.03 76 88873 11576 50504599
Abortion spontaneous 43.51 10.03 10 88939 41762 50474413
Gastrointestinal tract mucosal pigmentation 43.41 10.03 21 88928 563 50515612
Blood loss anaemia 43.24 10.03 62 88887 8077 50508098
Unresponsive to stimuli 43.04 10.03 135 88814 30474 50485701
Mitral valve incompetence 43.02 10.03 95 88854 17376 50498799
Ischaemic cardiomyopathy 42.29 10.03 34 88915 2278 50513897
Arrhythmia 40.20 10.03 139 88810 32993 50483182
Plasma cell myeloma 38.52 10.03 132 88817 31190 50484985
Coronary arterial stent insertion 38.43 10.03 34 88915 2600 50513575
Cardiac failure acute 38.31 10.03 59 88890 8191 50507984
Sleep disorder due to general medical condition, insomnia type 38.27 10.03 5 88944 31442 50484733
Myocardial ischaemia 37.93 10.03 71 88878 11542 50504633
Injection site pain 37.93 10.03 87 88862 110937 50405238
Therapeutic product effect incomplete 37.93 10.03 64 88885 91451 50424724
Pyrexia 37.86 10.03 457 88492 379746 50136429
Pregnancy 37.74 10.03 4 88945 29573 50486602
Renal disorder 37.47 10.03 120 88829 27385 50488790
Sinus bradycardia 37.46 10.03 76 88873 13107 50503068
Glycosylated haemoglobin increased 37.37 10.03 67 88882 10539 50505636
Irritable bowel syndrome 37.35 10.03 22 88927 51419 50464756
Ventricular arrhythmia 37.28 10.03 37 88912 3272 50512903
Blood potassium increased 36.86 10.03 86 88863 16312 50499863
Nasopharyngitis 34.15 10.03 199 88750 192728 50323447
Sinusitis 34.02 10.03 169 88780 170389 50345786
End stage renal disease 33.91 10.03 46 88903 5691 50510484
Calcium deficiency 33.84 10.03 21 88928 929 50515246
Isosthenuria 33.75 10.03 11 88938 98 50516077
Distributive shock 33.60 10.03 20 88929 820 50515355
Blister 33.35 10.03 62 88887 85356 50430819
Spinal epidural haematoma 33.06 10.03 21 88928 968 50515207
Orthopnoea 32.69 10.03 45 88904 5644 50510531
Extradural haematoma 32.62 10.03 25 88924 1562 50514613
Atrioventricular block first degree 32.59 10.03 47 88902 6154 50510021
Ill-defined disorder 32.36 10.03 29 88920 54625 50461550
Gastrointestinal disorder 32.28 10.03 74 88875 94382 50421793
Angina pectoris 31.88 10.03 110 88839 26078 50490097
Pericardial effusion 31.60 10.03 108 88841 25481 50490694
Febrile neutropenia 31.40 10.03 79 88870 97588 50418587
Pulse absent 30.65 10.03 40 88909 4766 50511409
Completed suicide 30.36 10.03 360 88589 131529 50384646
Blood urea increased 29.53 10.03 100 88849 23485 50492690
Fall 28.95 10.03 782 88167 334150 50182025
Stomatitis 28.83 10.03 87 88862 101257 50414918
Myxoedema coma 28.62 10.03 14 88935 385 50515790
Coronary artery occlusion 28.51 10.03 49 88900 7454 50508721
Ventricular hypokinesia 28.35 10.03 35 88914 3945 50512230
Pyelitis 28.24 10.03 11 88938 171 50516004
Ventricular tachycardia 28.23 10.03 76 88873 15745 50500430
Left ventricular dysfunction 28.01 10.03 59 88890 10447 50505728
Blood pressure inadequately controlled 27.23 10.03 36 88913 4344 50511831
Angina unstable 27.08 10.03 45 88904 6661 50509514
Injection site erythema 27.00 10.03 57 88892 74879 50441296
Red blood cell sedimentation rate increased 26.98 10.03 9 88940 29407 50486768
Arterial stenosis 26.62 10.03 15 88934 554 50515621
Bladder hypertrophy 26.26 10.03 11 88938 208 50515967
Acute respiratory failure 26.05 10.03 110 88839 28672 50487503
Subdural haematoma 25.99 10.03 65 88884 12882 50503293
Condition aggravated 25.88 10.03 367 88582 296691 50219484
Ischaemic stroke 25.88 10.03 74 88875 15874 50500301
Electrocardiogram PR shortened 25.65 10.03 11 88938 221 50515954
Respiratory failure 25.64 10.03 259 88690 90922 50425253
Tricuspid valve incompetence 25.51 10.03 64 88885 12706 50503469
Blood glucose decreased 25.30 10.03 80 88869 18131 50498044
Dialysis 25.16 10.03 53 88896 9385 50506790
Vessel puncture site haemorrhage 25.07 10.03 9 88940 110 50516065
Chronic obstructive pulmonary disease 24.82 10.03 170 88779 53265 50462910
Diastolic dysfunction 24.73 10.03 38 88911 5264 50510911
Left ventricular hypertrophy 24.42 10.03 36 88913 4809 50511366
Erythema 24.34 10.03 154 88795 146260 50369915
Loss of consciousness 24.08 10.03 285 88664 104068 50412107
Implantable defibrillator insertion 23.91 10.03 12 88937 349 50515826
Aortic valve incompetence 23.81 10.03 38 88911 5438 50510737
Intracardiac thrombus 23.78 10.03 24 88925 2165 50514010
Injection site reaction 23.61 10.03 32 88917 50000 50466175
Hip arthroplasty 23.56 10.03 12 88937 30417 50485758
Urinary tract infection 23.48 10.03 537 88412 223483 50292692
Genotype drug resistance test positive 23.30 10.03 11 88938 279 50515896
Mobility decreased 23.20 10.03 68 88881 79880 50436295
Melaena 23.03 10.03 101 88848 26763 50489412
Upper gastrointestinal haemorrhage 22.79 10.03 71 88878 15964 50500211
Pneumonia 22.33 10.03 844 88105 377557 50138618
Cerebral infarction 22.29 10.03 86 88863 21518 50494657
Brain natriuretic peptide increased 21.90 10.03 33 88916 4494 50511681
Urticaria 21.67 10.03 136 88813 129425 50386750
Hypovolaemia 21.66 10.03 50 88899 9415 50506760
Haemorrhage intracranial 21.64 10.03 59 88890 12315 50503860
Blood pressure increased 21.47 10.03 341 88608 132791 50383384
Decreased appetite 21.17 10.03 482 88467 200441 50315734
Migraine 21.14 10.03 65 88884 75215 50440960
Suicidal ideation 20.91 10.03 41 88908 55344 50460831
Blood pressure abnormal 20.54 10.03 59 88890 12688 50503487
Pleural effusion 20.38 10.03 226 88723 81228 50434947
Gout 20.37 10.03 55 88894 11415 50504760
Arteriosclerosis 19.74 10.03 47 88902 9030 50507145
Atrial flutter 19.74 10.03 46 88903 8717 50507458
Atrioventricular block complete 19.64 10.03 41 88908 7214 50508961
Left ventricular dilatation 19.26 10.03 11 88938 417 50515758
Basal ganglia haemorrhage 19.19 10.03 12 88937 538 50515637
Neutropenia 19.15 10.03 167 88782 147798 50368377
Cardio-respiratory arrest 19.15 10.03 161 88788 53731 50462444
Nephrogenic anaemia 19.09 10.03 19 88930 1686 50514489
Lower gastrointestinal haemorrhage 18.77 10.03 39 88910 6840 50509335
Device expulsion 18.66 10.03 14 88935 28808 50487367
Platelet dysfunction 18.57 10.03 7 88942 99 50516076
Pulmonary congestion 18.52 10.03 64 88885 15183 50500992
Leukopenia 18.47 10.03 59 88890 67469 50448706
Renal injury 18.09 10.03 44 88905 8567 50507608
Shock 17.98 10.03 78 88871 20572 50495603
Peripheral coldness 17.95 10.03 49 88900 10234 50505941
Pulseless electrical activity 17.75 10.03 38 88911 6803 50509372
Tendonitis 17.39 10.03 4 88945 16701 50499474
Renal hypoplasia 17.34 10.03 5 88944 28 50516147
Electrocardiogram QT shortened 17.24 10.03 7 88942 122 50516053
Femoral artery dissection 17.05 10.03 5 88944 30 50516145
Hypertensive emergency 16.73 10.03 17 88932 1546 50514629
Therapy cessation 16.69 10.03 90 88859 25921 50490254
Product use in unapproved indication 16.68 10.03 127 88822 115692 50400483
Bundle branch block left 16.62 10.03 35 88914 6195 50509980
Injection site swelling 16.58 10.03 30 88919 41743 50474432
Headache 16.56 10.03 725 88224 505810 50010365
Urine albumin/creatinine ratio increased 16.56 10.03 8 88941 214 50515961
Hypouricaemia 16.31 10.03 7 88942 141 50516034
Mucocutaneous haemorrhage 16.24 10.03 6 88943 80 50516095
Creatinine renal clearance increased 16.22 10.03 11 88938 567 50515608
Hypertensive encephalopathy 16.12 10.03 11 88938 573 50515602
Hydrothorax 16.10 10.03 12 88937 719 50515456
Coronary artery bypass 16.07 10.03 20 88929 2273 50513902
Electrocardiogram ST segment 16.04 10.03 3 88946 0 50516175
Vena cava injury 16.04 10.03 3 88946 0 50516175
Unevaluable event 16.04 10.03 137 88812 45929 50470246
Metabolic acidosis 15.99 10.03 120 88829 38705 50477470
Herbal interaction 15.84 10.03 6 88943 86 50516089
Renin increased 15.83 10.03 7 88942 152 50516023
Renal artery stenosis 15.78 10.03 17 88932 1655 50514520
Ventricular fibrillation 15.24 10.03 47 88902 10512 50505663
Pernicious anaemia 15.09 10.03 11 88938 637 50515538
Electrocardiogram abnormal 15.07 10.03 38 88911 7567 50508608
Toxic neuropathy 15.03 10.03 9 88940 373 50515802
Vascular stent stenosis 15.02 10.03 10 88939 500 50515675
Oropharyngeal pain 14.98 10.03 78 88871 77723 50438452
Haematocrit decreased 14.91 10.03 109 88840 34867 50481308
Embolic stroke 14.91 10.03 24 88925 3460 50512715
Cognitive disorder 14.72 10.03 35 88914 44088 50472087
Subdural haemorrhage 14.69 10.03 21 88928 2728 50513447
Transfusion 14.67 10.03 53 88896 12852 50503323
Diarrhoea 14.63 10.03 1212 87737 587264 49928911
Nephropathy 14.57 10.03 30 88919 5228 50510947
Medication error 14.54 10.03 111 88838 35993 50480182
Occult blood positive 14.53 10.03 23 88926 3268 50512907
Cardiac operation 14.42 10.03 21 88928 2774 50513401
Psoriatic arthropathy 14.38 10.03 39 88910 46993 50469182
Asthma 14.31 10.03 95 88854 89242 50426933
Basal cell carcinoma 14.30 10.03 12 88937 23344 50492831
Foot deformity 14.25 10.03 8 88941 19202 50496973
Hyperglycaemia 14.14 10.03 111 88838 36294 50479881
Renal atrophy 14.08 10.03 14 88935 1241 50514934
Inflammation 14.03 10.03 52 88897 56860 50459315
Intentional self-injury 14.00 10.03 12 88937 23100 50493075
Urine output decreased 13.77 10.03 45 88904 10376 50505799
Presyncope 13.72 10.03 81 88868 24117 50492058
Lethargy 13.69 10.03 140 88809 49292 50466883
Chronic left ventricular failure 13.62 10.03 8 88941 320 50515855
Loss of personal independence in daily activities 13.61 10.03 70 88879 69980 50446195
Insulin-requiring type 2 diabetes mellitus 13.51 10.03 5 88944 67 50516108
Oral herpes 13.51 10.03 10 88939 20715 50495460
Paraplegia 13.49 10.03 19 88930 2435 50513740
Foetal exposure during pregnancy 13.42 10.03 17 88932 27342 50488833
Palpitations 13.37 10.03 237 88712 94269 50421906
Hypophagia 13.34 10.03 89 88860 27639 50488536
Intentional product use issue 13.24 10.03 80 88869 76838 50439337
Fibromyalgia 13.23 10.03 38 88911 44940 50471235
Cholestatic liver injury 13.17 10.03 17 88932 2004 50514171
C-reactive protein increased 13.16 10.03 66 88883 66408 50449767
Muscle spasticity 12.97 10.03 7 88942 17177 50498998
Body temperature increased 12.90 10.03 22 88927 31319 50484856
Pulmonary arterial pressure increased 12.90 10.03 22 88927 3326 50512849
Subarachnoid haemorrhage 12.89 10.03 45 88904 10731 50505444
Hyponatraemia 12.86 10.03 239 88710 95900 50420275
Arterial occlusive disease 12.82 10.03 27 88922 4781 50511394
Haematuria 12.80 10.03 83 88866 25530 50490645
Injection site pruritus 12.74 10.03 33 88916 40378 50475797
Supraventricular extrasystoles 12.74 10.03 24 88925 3920 50512255
Gastritis erosive 12.73 10.03 28 88921 5106 50511069
Fear 12.70 10.03 55 88894 14494 50501681
Peripheral vascular disorder 12.64 10.03 29 88920 5438 50510737
Hypertension 12.64 10.03 472 88477 210731 50305444
Angioedema 12.57 10.03 111 88838 37565 50478610
Azotaemia 12.47 10.03 24 88925 3984 50512191
Transient ischaemic attack 12.40 10.03 98 88851 32112 50484063
Catheterisation cardiac 12.33 10.03 24 88925 4016 50512159
Drug dependence 12.28 10.03 10 88939 19749 50496426
Renal tubular injury 12.25 10.03 8 88941 387 50515788
N-terminal prohormone brain natriuretic peptide increased 12.12 10.03 15 88934 1695 50514480
Long QT syndrome 12.10 10.03 20 88929 2947 50513228
Hospitalisation 12.09 10.03 177 88772 67760 50448415
Breast cancer recurrent 12.09 10.03 23 88926 3785 50512390
Intercepted product dispensing error 12.01 10.03 5 88944 93 50516082
Cardiac murmur 12.01 10.03 44 88905 10740 50505435
Refractory anaemia with an excess of blasts 12.00 10.03 8 88941 401 50515774
Gastrointestinal arteriovenous malformation 11.96 10.03 9 88940 547 50515628
Extrapyramidal disorder 11.90 10.03 3 88946 11767 50504408
Traumatic renal injury 11.89 10.03 3 88946 9 50516166
Hip fracture 11.74 10.03 82 88867 25849 50490326
Bone marrow failure 11.73 10.03 19 88930 27605 50488570
Aortic stenosis 11.70 10.03 24 88925 4170 50512005
Blood aldosterone abnormal 11.69 10.03 4 88945 42 50516133
Bursitis 11.66 10.03 13 88936 22122 50494053
Malignant neoplasm progression 11.65 10.03 71 88878 68053 50448122
Diarrhoea infectious 11.59 10.03 11 88938 921 50515254
Electrocardiogram QRS complex shortened 11.56 10.03 8 88941 426 50515749
Carbohydrate antigen 15-3 increased 11.55 10.03 12 88937 1120 50515055
Cardiac pacemaker insertion 11.52 10.03 22 88927 3631 50512544
Premature labour 11.46 10.03 3 88946 11473 50504702
Epinephrine increased 11.44 10.03 3 88946 11 50516164
Hypovolaemic shock 11.43 10.03 27 88922 5161 50511014
Arteriovenous fistula thrombosis 11.38 10.03 6 88943 194 50515981
Thrombosis 11.37 10.03 149 88800 55684 50460491
Anti-neutrophil cytoplasmic antibody positive vasculitis 11.34 10.03 17 88932 2305 50513870
Platelet count decreased 11.34 10.03 244 88705 100482 50415693
Torsade de pointes 11.31 10.03 46 88903 11789 50504386
Ischaemia 11.30 10.03 24 88925 4273 50511902
Breath sounds 11.29 10.03 5 88944 109 50516066
Cytomegalovirus infection 11.28 10.03 9 88940 17953 50498222
Vascular pseudoaneurysm 11.22 10.03 13 88936 1371 50514804
Hypercapnia 11.21 10.03 25 88924 4602 50511573
Arthritis 11.16 10.03 98 88851 86623 50429552
Hypochloraemia 10.96 10.03 14 88935 1633 50514542
Ventricular extrasystoles 10.96 10.03 42 88907 10474 50505701
Bradyarrhythmia 10.94 10.03 15 88934 1875 50514300
Pulmonary hypertension 10.91 10.03 98 88851 33319 50482856
Blood blister 10.87 10.03 14 88935 1646 50514529
Glomerulonephritis rapidly progressive 10.82 10.03 10 88939 809 50515366
Oral cavity fistula 10.80 10.03 9 88940 634 50515541
Post procedural hypothyroidism 10.77 10.03 5 88944 122 50516053
Multiple sclerosis relapse 10.75 10.03 39 88910 42925 50473250
Injection site urticaria 10.75 10.03 4 88945 12213 50503962
Electrocardiogram T wave inversion 10.73 10.03 20 88929 3241 50512934
Sleep disorder 10.71 10.03 58 88891 57225 50458950
Phaeochromocytoma crisis 10.66 10.03 6 88943 221 50515954
Prothrombin time prolonged 10.65 10.03 37 88912 8801 50507374
Sinus arrest 10.62 10.03 14 88935 1684 50514491
Carcinoembryonic antigen increased 10.56 10.03 13 88936 1461 50514714
Rhabdomyolysis 10.55 10.03 110 88839 38917 50477258
Herpes zoster 10.48 10.03 77 88872 70709 50445466
Quadriplegia 10.46 10.03 14 88935 1709 50514466
Sudden cardiac death 10.44 10.03 15 88934 1957 50514218
Product dose omission issue 10.32 10.03 408 88541 183430 50332745
Ectopic ACTH syndrome 10.30 10.03 5 88944 135 50516040
Hepatocellular carcinoma 10.29 10.03 15 88934 1984 50514191
Retinopathy hypertensive 10.28 10.03 6 88943 237 50515938
Chemotherapeutic drug level increased 10.27 10.03 5 88944 136 50516039
Right aortic arch 10.26 10.03 6 88943 238 50515937
Product residue present 10.23 10.03 21 88928 3651 50512524
Joint stiffness 10.14 10.03 24 88925 30284 50485891
Dyspnoea exertional 10.13 10.03 136 88813 51097 50465078
Hypercreatininaemia 10.10 10.03 7 88942 374 50515801

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Cardiac failure congestive 1088.13 10.46 1334 101435 75247 29396511
Myocardial infarction 400.77 10.46 1057 101712 109239 29362519
Cardiac failure 384.73 10.46 850 101919 78437 29393321
Hypotension 381.32 10.46 1507 101262 192847 29278911
Bradycardia 289.77 10.46 678 102091 64951 29406807
Ejection fraction decreased 181.88 10.46 250 102519 15728 29456030
Coronary artery disease 163.62 10.46 427 102342 43763 29427995
Off label use 160.75 10.46 524 102245 300276 29171482
Hyperkalaemia 153.54 10.46 516 102253 60876 29410882
Drug abuse 150.97 10.46 45 102724 79838 29391920
Acute myocardial infarction 143.85 10.46 432 102337 48006 29423752
Syncope 130.90 10.46 595 102174 80776 29390982
Cardiac failure chronic 129.59 10.46 135 102634 6332 29465426
Ischaemic cardiomyopathy 128.16 10.46 126 102643 5512 29466246
Mitral valve incompetence 123.58 10.46 189 102580 13104 29458654
Dizziness 116.80 10.46 1087 101682 188597 29283161
Dyspnoea 107.29 10.46 1660 101109 325072 29146686
Atrial fibrillation 106.76 10.46 680 102089 104966 29366792
Ventricular tachycardia 104.72 10.46 238 102531 22336 29449422
Cardiac failure acute 98.88 10.46 140 102629 9052 29462706
Pyrexia 96.14 10.46 596 102173 287026 29184732
Blood pressure decreased 95.45 10.46 361 102408 45116 29426642
Foetal exposure during pregnancy 93.89 10.46 6 102763 33861 29437897
Gastrointestinal haemorrhage 93.10 10.46 532 102237 79001 29392757
Drug ineffective 92.94 10.46 812 101957 362358 29109400
Cardiac disorder 91.15 10.46 311 102458 36952 29434806
Neutropenia 90.79 10.46 202 102567 131509 29340249
Febrile neutropenia 90.43 10.46 157 102612 112083 29359675
Cardiomyopathy 83.66 10.46 169 102600 14618 29457140
Chronic kidney disease 80.52 10.46 294 102475 36122 29435636
International normalised ratio increased 76.97 10.46 332 102437 44040 29427718
Cardiomegaly 72.70 10.46 153 102616 13623 29458135
Blood potassium increased 64.13 10.46 151 102618 14500 29457258
Cerebrovascular accident 63.35 10.46 471 102298 76440 29395318
Computerised tomogram coronary artery abnormal 60.79 10.46 24 102745 184 29471574
Completed suicide 58.83 10.46 524 102245 89722 29382036
Congestive cardiomyopathy 57.07 10.46 91 102678 6539 29465219
Left ventricular dilatation 56.83 10.46 33 102736 637 29471121
Treatment failure 56.27 10.46 29 102740 36910 29434848
Bundle branch block left 56.20 10.46 80 102689 5197 29466561
Toxicity to various agents 55.22 10.46 365 102404 173296 29298462
Tricuspid valve incompetence 52.40 10.46 100 102669 8294 29463464
Pulmonary oedema 51.36 10.46 288 102481 42447 29429311
Ventricular hypokinesia 51.29 10.46 71 102698 4494 29467264
Blood creatinine increased 49.85 10.46 483 102286 84619 29387139
Rheumatoid arthritis 49.33 10.46 25 102744 32127 29439631
Orthopnoea 48.37 10.46 69 102700 4491 29467267
Product use in unapproved indication 47.79 10.46 149 102620 86726 29385032
Presyncope 47.24 10.46 143 102626 15946 29455812
Coronary arterial stent insertion 45.88 10.46 62 102707 3835 29467923
Renal impairment 45.87 10.46 458 102311 80875 29390883
Oedema peripheral 45.07 10.46 554 102215 103003 29368755
N-terminal prohormone brain natriuretic peptide abnormal 44.65 10.46 19 102750 180 29471578
Coronary artery bypass 44.08 10.46 67 102702 4618 29467140
Suicidal ideation 42.36 10.46 35 102734 34681 29437077
Fluid retention 42.16 10.46 178 102591 23382 29448376
Chest pain 42.02 10.46 583 102186 111390 29360368
N-terminal prohormone brain natriuretic peptide increased 41.73 10.46 42 102727 1890 29469868
Drug reaction with eosinophilia and systemic symptoms 41.13 10.46 23 102746 27969 29443789
Cardiac arrest 40.81 10.46 466 102303 85125 29386633
Malignant neoplasm progression 40.39 10.46 127 102642 73732 29398026
Hypoglycaemia 40.30 10.46 297 102472 48049 29423709
Premature baby 40.24 10.46 6 102763 17274 29454484
Leukopenia 40.20 10.46 82 102687 55121 29416637
Atrioventricular block 39.73 10.46 80 102689 6902 29464856
Suicide attempt 39.66 10.46 36 102733 34074 29437684
Acute kidney injury 39.49 10.46 1203 101566 264064 29207694
Blood loss anaemia 38.68 10.46 81 102688 7185 29464573
Angina pectoris 38.44 10.46 195 102574 27655 29444103
Agitation 37.53 10.46 76 102693 51228 29420530
Mucosal inflammation 37.15 10.46 33 102736 31562 29440196
Arthralgia 36.01 10.46 311 102458 139306 29332452
Sinus bradycardia 35.84 10.46 105 102664 11498 29460260
Drug dependence 35.82 10.46 14 102755 20967 29450791
Peritonitis bacterial 35.22 10.46 68 102701 5688 29466070
Diastolic dysfunction 34.96 10.46 63 102706 5001 29466757
Electrocardiogram abnormal 34.84 10.46 78 102691 7244 29464514
Renal failure 33.97 10.46 590 102179 118009 29353749
Rales 33.51 10.46 78 102691 7432 29464326
Carotid sinus syndrome 33.40 10.46 10 102759 28 29471730
Aggression 33.10 10.46 45 102724 35496 29436262
Left ventricular dysfunction 32.88 10.46 86 102683 8816 29462942
Blood pressure inadequately controlled 32.83 10.46 41 102728 2345 29469413
Hypervolaemia 32.52 10.46 134 102635 17411 29454347
Fractured coccyx 31.39 10.46 14 102755 150 29471608
Heart rate decreased 31.33 10.46 170 102599 24742 29447016
Depression 31.20 10.46 171 102598 84976 29386782
Type V hyperlipidaemia 31.20 10.46 23 102746 674 29471084
Asthenia 31.14 10.46 973 101796 214277 29257481
Brain natriuretic peptide abnormal 30.38 10.46 17 102752 305 29471453
Ventricular internal diameter abnormal 30.28 10.46 12 102757 93 29471665
Arrhythmia 29.99 10.46 199 102570 31114 29440644
Mouth breathing 29.87 10.46 11 102758 68 29471690
Therapeutic product effect incomplete 29.80 10.46 57 102712 39248 29432510
Intentional self-injury 29.78 10.46 4 102765 12457 29459301
Lower respiratory tract infection 29.60 10.46 29 102740 26473 29445285
Rash 29.15 10.46 474 102295 189345 29282413
Intentional overdose 29.10 10.46 56 102713 38472 29433286
Cardiogenic shock 29.08 10.46 138 102631 19052 29452706
Nodal rhythm 29.07 10.46 29 102740 1291 29470467
Hepatocellular injury 29.05 10.46 19 102750 21224 29450534
Pulmonary valve disease 28.84 10.46 16 102753 282 29471476
Sudden cardiac death 28.80 10.46 45 102724 3177 29468581
Bradyarrhythmia 28.75 10.46 35 102734 1950 29469808
Cardioactive drug level increased 28.71 10.46 32 102737 1621 29470137
Pancytopenia 28.33 10.46 171 102598 82997 29388761
Cholestasis 28.20 10.46 24 102745 23438 29448320
Infusion related reaction 28.03 10.46 70 102699 43816 29427942
Alanine aminotransferase increased 27.94 10.46 139 102630 70805 29400953
Death 27.76 10.46 1453 101316 340631 29131127
Intentional product use issue 27.76 10.46 67 102702 42431 29429327
Generalised tonic-clonic seizure 27.72 10.46 16 102753 19123 29452635
Pericardial disease 27.68 10.46 17 102752 365 29471393
Neutrophil count decreased 27.43 10.46 70 102699 43497 29428261
Nodal arrhythmia 26.88 10.46 22 102747 754 29471004
Sinus arrest 26.85 10.46 29 102740 1418 29470340
Thrombocytopenia 26.62 10.46 320 102449 134503 29337255
Blood urea increased 26.52 10.46 178 102591 27934 29443824
Ventricular arrhythmia 26.49 10.46 53 102716 4551 29467207
Blood glucose decreased 26.29 10.46 97 102672 11972 29459786
Pulmonary hypertension 26.17 10.46 131 102638 18477 29453281
Seizure 26.01 10.46 203 102566 92920 29378838
Coma 25.92 10.46 62 102707 39388 29432370
Electrocardiogram QRS complex abnormal 25.67 10.46 15 102754 293 29471465
Shock 25.54 10.46 144 102625 21260 29450498
Orthostatic hypotension 25.53 10.46 150 102619 22479 29449279
Injection site pain 25.53 10.46 46 102723 32400 29439358
Pulmonary arterial pressure abnormal 25.41 10.46 13 102756 193 29471565
Musculoskeletal stiffness 25.31 10.46 58 102711 37400 29434358
Suspected suicide 25.22 10.46 48 102721 3972 29467786
Fall 25.09 10.46 799 101970 176379 29295379
Blood thyroid stimulating hormone abnormal 24.97 10.46 14 102755 252 29471506
Glomerular filtration rate decreased 24.92 10.46 91 102678 11175 29460583
Drug resistance 24.72 10.46 23 102746 21517 29450241
Sedation 24.58 10.46 15 102754 17390 29454368
Jugular vein distension 24.38 10.46 19 102750 606 29471152
Cardiac discomfort 24.27 10.46 17 102752 459 29471299
Cytomegalovirus infection 24.13 10.46 27 102742 23188 29448570
Neuroleptic malignant syndrome 24.11 10.46 13 102756 16135 29455623
Erythema 23.93 10.46 159 102610 75447 29396311
Brain natriuretic peptide increased 23.51 10.46 48 102721 4182 29467576
Dyspnoea at rest 23.49 10.46 41 102728 3173 29468585
Cardio-respiratory arrest 23.42 10.46 274 102495 50327 29421431
Rash maculo-papular 23.39 10.46 30 102739 24259 29447499
Neutrophil count increased 23.31 10.46 11 102758 14731 29457027
Candida infection 23.11 10.46 12 102757 15213 29456545
Agranulocytosis 23.02 10.46 22 102747 20318 29451440
Blood glucose increased 22.86 10.46 309 102460 58675 29413083
Oesophageal discomfort 22.81 10.46 8 102761 42 29471716
Nephrogenic anaemia 22.49 10.46 31 102738 1954 29469804
Haemorrhage intracranial 22.34 10.46 105 102664 14437 29457321
Hypertensive crisis 22.33 10.46 69 102700 7779 29463979
Cerebral infarction 21.95 10.46 154 102615 24521 29447237
Renal cyst haemorrhage 21.90 10.46 15 102754 390 29471368
Glomerular filtration rate abnormal 21.48 10.46 19 102750 725 29471033
Oxygen saturation increased 21.42 10.46 13 102756 273 29471485
Lymphadenopathy 21.10 10.46 34 102735 25015 29446743
Graft versus host disease 20.97 10.46 4 102765 9624 29462134
Angina unstable 20.94 10.46 84 102685 10781 29460977
Serotonin syndrome 20.94 10.46 18 102751 17494 29454264
Drug withdrawal syndrome 20.88 10.46 19 102750 17965 29453793
Bone marrow failure 20.64 10.46 40 102729 27409 29444349
Conjunctival scar 20.41 10.46 8 102761 60 29471698
Dyspnoea exertional 20.31 10.46 205 102564 36285 29435473
Mitral valve calcification 20.27 10.46 16 102753 520 29471238
Loss of personal independence in daily activities 20.07 10.46 36 102733 25404 29446354
Lymphopenia 20.05 10.46 11 102758 13522 29458236
Respiratory depression 20.03 10.46 11 102758 13512 29458246
Dizziness postural 19.98 10.46 52 102717 5315 29466443
Pulmonary embolism 19.92 10.46 170 102599 76364 29395394
Bundle branch block 19.90 10.46 19 102750 801 29470957
Ventricular fibrillation 19.87 10.46 108 102661 15725 29456033
Neutropenic sepsis 19.73 10.46 8 102761 11719 29460039
Atrioventricular block complete 19.69 10.46 67 102702 7944 29463814
End stage renal disease 19.64 10.46 65 102704 7599 29464159
Physical examination abnormal 19.32 10.46 12 102757 263 29471495
Hyperparathyroidism secondary 19.31 10.46 23 102746 1252 29470506
Glycosylated haemoglobin increased 19.08 10.46 74 102695 9352 29462406
Fatigue 18.92 10.46 1310 101459 315511 29156247
Vomiting 18.79 10.46 578 102191 211682 29260076
Arteriosclerosis 18.74 10.46 78 102691 10178 29461580
Full blood count decreased 18.69 10.46 107 102662 15885 29455873
Hepatitis 18.67 10.46 27 102742 20756 29451002
Oedema 18.64 10.46 219 102550 40264 29431494
Mitral valve disease 18.61 10.46 22 102747 1188 29470570
Ejection fraction abnormal 18.44 10.46 18 102751 780 29470978
Torsade de pointes 18.43 10.46 58 102711 6603 29465155
Concomitant disease progression 18.42 10.46 31 102738 2330 29469428
Progressive multifocal leukoencephalopathy 18.20 10.46 4 102765 8715 29463043
Aspergillus infection 18.16 10.46 7 102762 10574 29461184
Haemophagocytic lymphohistiocytosis 17.95 10.46 7 102762 10497 29461261
Stenosis 17.82 10.46 20 102749 1021 29470737
Drug hypersensitivity 17.77 10.46 152 102617 68254 29403504
Tremor 17.54 10.46 167 102602 73371 29398387
Epilepsy 17.50 10.46 23 102746 18409 29453349
Arterial spasm 17.44 10.46 8 102761 92 29471666
Gingival hypertrophy 17.38 10.46 25 102744 1640 29470118
Myocardial ischaemia 17.28 10.46 105 102664 15923 29455835
Osteonecrosis 17.28 10.46 13 102756 13506 29458252
Urticaria 17.26 10.46 115 102654 54545 29417213
Gallbladder oedema 17.22 10.46 10 102759 193 29471565
Abnormal behaviour 17.13 10.46 34 102735 23093 29448665
Left atrial dilatation 17.06 10.46 25 102744 1668 29470090
Implantable defibrillator insertion 16.99 10.46 16 102753 663 29471095
Rectal prolapse 16.98 10.46 11 102758 260 29471498
Hypovolaemia 16.97 10.46 64 102705 7981 29463777
Bronchopulmonary aspergillosis 16.93 10.46 11 102758 12333 29459425
Tumour lysis syndrome 16.93 10.46 14 102755 13870 29457888
Pneumocystis jirovecii pneumonia 16.91 10.46 20 102749 16759 29454999
Conduction disorder 16.87 10.46 26 102743 1814 29469944
Psychotic disorder 16.79 10.46 28 102741 20326 29451432
Vena cava injury 16.56 10.46 10 102759 208 29471550
Atrioventricular block second degree 16.50 10.46 35 102734 3133 29468625
Pulse waveform abnormal 16.44 10.46 4 102765 3 29471755
Pathogen resistance 16.39 10.46 4 102765 8112 29463646
Vascular graft 16.31 10.46 22 102747 1358 29470400
Acute pulmonary oedema 16.06 10.46 56 102713 6723 29465035
Cardiac pacemaker insertion 16.05 10.46 30 102739 2449 29469309
Mitral valve thickening 16.00 10.46 12 102757 361 29471397
Ventricular extrasystoles 15.96 10.46 76 102693 10506 29461252
SARS-CoV-2 antibody test positive 15.95 10.46 10 102759 223 29471535
Pulmonary renal syndrome 15.91 10.46 9 102760 165 29471593
Extrapyramidal disorder 15.76 10.46 9 102760 10822 29460936
Carotid arteriosclerosis 15.61 10.46 22 102747 1416 29470342
Immune reconstitution inflammatory syndrome 15.46 10.46 4 102765 7798 29463960
Carotid artery stenosis 15.32 10.46 42 102727 4427 29467331
Upper gastrointestinal haemorrhage 15.16 10.46 129 102640 21785 29449973
C-reactive protein increased 15.07 10.46 91 102678 44172 29427586
Cerebral haemorrhage 14.91 10.46 171 102598 31255 29440503
Azotaemia 14.81 10.46 42 102727 4515 29467243
Intraductal papillary mucinous neoplasm 14.72 10.46 11 102758 329 29471429
Disturbance in attention 14.61 10.46 33 102736 21391 29450367
Anger 14.54 10.46 10 102759 10880 29460878
Mouth ulceration 14.51 10.46 9 102760 10346 29461412
Substance abuse 14.40 10.46 3 102766 6784 29464974
Periodontitis 14.36 10.46 24 102745 1793 29469965
Cardiac ventricular thrombosis 14.32 10.46 17 102752 922 29470836
Osteonecrosis of jaw 14.29 10.46 22 102747 16488 29455270
Cardioversion 14.16 10.46 16 102753 823 29470935
Subdural haematoma 14.16 10.46 110 102659 18083 29453675
Coronary artery occlusion 14.15 10.46 71 102698 10023 29461735
Oral candidiasis 14.11 10.46 10 102759 10712 29461046
Myelosuppression 14.10 10.46 13 102756 12214 29459544
Aspartate aminotransferase increased 14.08 10.46 136 102633 59589 29412169
Epstein-Barr virus infection 13.92 10.46 3 102766 6626 29465132
Intracardiac thrombus 13.90 10.46 27 102742 2268 29469490
Pulmonary arterial pressure increased 13.90 10.46 18 102751 1068 29470690
Stomatitis 13.87 10.46 74 102695 37039 29434719
Cardioactive drug level above therapeutic 13.73 10.46 6 102763 61 29471697
Gastrointestinal endoscopic therapy 13.69 10.46 4 102765 10 29471748
Systolic dysfunction 13.66 10.46 26 102743 2152 29469606
Gravitational oedema 13.62 10.46 13 102756 548 29471210
Atrioventricular block first degree 13.53 10.46 45 102724 5274 29466484
Blood pressure abnormal 13.49 10.46 53 102716 6737 29465021
Tachycardia induced cardiomyopathy 13.44 10.46 7 102762 108 29471650
Diverticulum intestinal 13.42 10.46 33 102736 3257 29468501
Hallucination 13.17 10.46 96 102673 44616 29427142
Atrial flutter 13.12 10.46 88 102681 13806 29457952
Renal artery stenosis 13.03 10.46 24 102745 1937 29469821
Colitis 13.01 10.46 60 102709 31188 29440570
Symblepharon 12.84 10.46 7 102762 119 29471639
Acute respiratory distress syndrome 12.83 10.46 39 102730 22896 29448862
Dilatation atrial 12.69 10.46 23 102746 1834 29469924
Cardiac output decreased 12.65 10.46 15 102754 813 29470945
Miosis 12.63 10.46 6 102763 8003 29463755
Non-compaction cardiomyopathy 12.59 10.46 5 102764 39 29471719
Atrial septal defect 12.50 10.46 4 102765 6785 29464973
Embolic stroke 12.47 10.46 34 102735 3572 29468186
Aortic valve incompetence 12.39 10.46 42 102727 4971 29466787
Heart rate abnormal 12.38 10.46 21 102748 1588 29470170
Eczema 12.38 10.46 18 102751 13808 29457950
Posterior reversible encephalopathy syndrome 12.31 10.46 8 102761 8968 29462790
Human ehrlichiosis 12.13 10.46 8 102761 195 29471563
Supraventricular tachycardia 12.12 10.46 67 102702 9817 29461941
Injection site swelling 12.11 10.46 9 102760 9408 29462350
Left atrial enlargement 12.10 10.46 14 102755 739 29471019
Blood pressure systolic decreased 12.07 10.46 35 102734 3809 29467949
Hydrothorax 12.07 10.46 11 102758 437 29471321
Hypoglycaemic unconsciousness 11.95 10.46 14 102755 749 29471009
Procedural hypotension 11.78 10.46 15 102754 875 29470883
Somnolence 11.76 10.46 243 102526 93712 29378046
Internal haemorrhage 11.75 10.46 38 102731 4389 29467369
Inspiratory capacity decreased 11.73 10.46 6 102763 89 29471669
Lower gastrointestinal haemorrhage 11.68 10.46 58 102711 8155 29463603
Injection site reaction 11.64 10.46 13 102756 11175 29460583
Cerebellar haemorrhage 11.63 10.46 19 102750 1393 29470365
Hyperuricaemia 11.52 10.46 51 102718 6838 29464920
Sexual dysfunction 11.48 10.46 3 102766 5811 29465947
Eosinophilia 11.48 10.46 39 102730 22122 29449636
Gout 11.41 10.46 99 102670 16812 29454946
Tubulointerstitial nephritis 11.37 10.46 28 102741 17615 29454143
Labile blood pressure 11.34 10.46 12 102757 573 29471185
Incarcerated hernia 11.33 10.46 7 102762 152 29471606
Chronic left ventricular failure 11.32 10.46 10 102759 381 29471377
Haematochezia 11.30 10.46 186 102583 36797 29434961
Pain 11.26 10.46 484 102285 170948 29300810
Chills 11.26 10.46 177 102592 71123 29400635
Hepatic enzyme increased 11.23 10.46 70 102699 33729 29438029
Ventricular dysfunction 11.12 10.46 31 102738 3300 29468458
Inflammation 11.11 10.46 41 102728 22687 29449071
Goitre 11.10 10.46 19 102750 1448 29470310
Dialysis 11.09 10.46 67 102702 10141 29461617
Toxic goitre 11.07 10.46 3 102766 5 29471753
Electrocardiogram Q wave abnormal 11.06 10.46 9 102760 306 29471452
Low cardiac output syndrome 11.02 10.46 11 102758 490 29471268
Anti-neutrophil cytoplasmic antibody positive vasculitis 10.98 10.46 13 102756 703 29471055
Coagulation factor increased 10.94 10.46 5 102764 57 29471701
Bronchostenosis 10.89 10.46 8 102761 233 29471525
Multiple organ dysfunction syndrome 10.89 10.46 154 102615 62962 29408796
Klebsiella infection 10.85 10.46 6 102763 7343 29464415
Acute generalised exanthematous pustulosis 10.80 10.46 3 102766 5580 29466178
Periorbital haemorrhage 10.80 10.46 6 102763 106 29471652
Large intestinal haemorrhage 10.72 10.46 19 102750 1488 29470270
Overdose 10.72 10.46 204 102565 79615 29392143
Hepatic cytolysis 10.70 10.46 8 102761 8339 29463419
Shunt occlusion 10.70 10.46 13 102756 723 29471035
Delusion 10.64 10.46 14 102755 11202 29460556
Sepsis 10.62 10.46 397 102372 142285 29329473
Lymphocyte count decreased 10.62 10.46 33 102736 19238 29452520
Haemorrhagic cerebral infarction 10.60 10.46 13 102756 730 29471028
Haematotoxicity 10.59 10.46 5 102764 6694 29465064
Product use issue 10.56 10.46 121 102648 51323 29420435
Hepatitis B 10.55 10.46 3 102766 5494 29466264
Toxic skin eruption 10.53 10.46 11 102758 9746 29462012
Dilatation ventricular 10.51 10.46 25 102744 2415 29469343
Sinusitis 10.48 10.46 73 102696 34277 29437481
Dyspnoea paroxysmal nocturnal 10.47 10.46 18 102751 1376 29470382
Echocardiogram abnormal 10.47 10.46 14 102755 857 29470901

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Cardiac failure congestive 2150.99 9.67 2080 155289 128500 64212863
Myocardial infarction 825.68 9.67 1463 155906 164358 64177005
Cardiac failure 643.26 9.67 1156 156213 131217 64210146
Hypotension 586.33 9.67 2149 155220 378825 63962538
Bradycardia 547.11 9.67 1011 156358 117208 64224155
Hyperkalaemia 347.09 9.67 764 156605 100365 64240998
Acute myocardial infarction 334.62 9.67 606 156763 69112 64272251
Coronary artery disease 308.91 9.67 540 156829 59893 64281470
Drug ineffective 263.16 9.67 1108 156261 839139 63502224
Ejection fraction decreased 253.31 9.67 331 157038 28376 64312987
Syncope 231.27 9.67 877 156492 156758 64184605
Gastrointestinal haemorrhage 204.78 9.67 749 156620 131563 64209800
Synovitis 193.90 9.67 12 157357 99078 64242285
Atrial fibrillation 193.67 9.67 879 156490 170210 64171153
Off label use 192.41 9.67 843 156526 631963 63709400
Rheumatoid arthritis 192.26 9.67 80 157289 164214 64177149
Acute kidney injury 189.55 9.67 1798 155571 447442 63893921
Cardiac failure chronic 179.15 9.67 160 157209 8881 64332482
Ischaemic cardiomyopathy 176.67 9.67 141 157228 6697 64334666
Infusion related reaction 169.70 9.67 95 157274 164372 64176991
Dyspnoea 169.31 9.67 2573 154796 716101 63625262
Drug abuse 167.33 9.67 57 157312 132317 64209046
Cardiomyopathy 165.31 9.67 253 157116 25103 64316260
International normalised ratio increased 165.21 9.67 496 156873 78671 64262692
Chronic kidney disease 161.91 9.67 404 156965 57515 64283848
Treatment failure 158.99 9.67 44 157325 116772 64224591
Mitral valve incompetence 156.99 9.67 248 157121 25290 64316073
Joint swelling 156.28 9.67 177 157192 215205 64126158
Arthralgia 151.30 9.67 562 156807 441698 63899665
Death 148.14 9.67 1813 155556 480892 63860471
Ventricular tachycardia 137.36 9.67 276 157093 33989 64307374
Cerebrovascular accident 136.09 9.67 680 156689 136903 64204460
Drug intolerance 134.73 9.67 156 157213 187836 64153527
Cardiac failure acute 134.25 9.67 182 157187 16162 64325201
Renal impairment 134.03 9.67 668 156701 134349 64207014
Cardiomegaly 131.98 9.67 220 157149 23464 64317899
Cardiac disorder 130.21 9.67 364 157005 55452 64285911
Lower respiratory tract infection 126.23 9.67 37 157332 94577 64246786
Blood creatinine increased 125.16 9.67 658 156711 135124 64206239
Hand deformity 124.62 9.67 7 157362 62764 64278599
Renal failure 121.99 9.67 810 156559 180878 64160485
Oedema peripheral 120.97 9.67 903 156466 209414 64131949
Blood pressure decreased 119.28 9.67 471 156898 85728 64255635
Maternal exposure during pregnancy 118.22 9.67 43 157326 95841 64245522
Hypoglycaemia 117.07 9.67 482 156887 89410 64251953
Systemic lupus erythematosus 115.88 9.67 24 157345 77588 64263775
Pain 115.37 9.67 834 156535 552677 63788686
Pulmonary oedema 108.94 9.67 430 156939 78244 64263119
Arthropathy 108.27 9.67 82 157287 120885 64220478
Therapeutic product effect decreased 106.08 9.67 76 157293 115275 64226088
Rash 103.86 9.67 674 156695 457875 63883488
Dizziness 101.18 9.67 1541 155828 428622 63912741
Chest pain 100.93 9.67 948 156421 235032 64106331
Hepatic enzyme increased 100.66 9.67 101 157268 129842 64211521
Alopecia 99.92 9.67 156 157213 165534 64175829
Congestive cardiomyopathy 98.67 9.67 124 157245 10220 64331143
Musculoskeletal stiffness 97.47 9.67 94 157275 123112 64218251
Pericarditis 96.12 9.67 18 157351 62498 64278865
Atrioventricular block 95.97 9.67 132 157237 11883 64329480
Coronary arterial stent insertion 95.86 9.67 92 157277 5600 64335763
Pyrexia 93.96 9.67 891 156478 557753 63783610
Hypersensitivity 90.57 9.67 217 157152 196235 64145128
Cardiac arrest 90.53 9.67 665 156704 153399 64187964
Febrile neutropenia 89.14 9.67 204 157165 187453 64153910
Cardiogenic shock 87.26 9.67 223 157146 32204 64309159
Completed suicide 84.49 9.67 878 156491 223536 64117827
Tricuspid valve incompetence 84.32 9.67 150 157219 16853 64324510
Glossodynia 83.23 9.67 27 157342 64669 64276694
Contraindicated product administered 82.15 9.67 85 157284 107744 64233619
Drug hypersensitivity 79.33 9.67 305 157064 237510 64103853
Blood potassium increased 78.74 9.67 187 157182 25793 64315570
Sinusitis 77.39 9.67 149 157220 145779 64195584
Bundle branch block left 76.80 9.67 108 157261 9926 64331437
Angina pectoris 76.34 9.67 263 157106 44818 64296545
Neutropenia 75.70 9.67 314 157055 239310 64102053
Injection site pain 74.97 9.67 97 157272 111311 64230052
Sinus bradycardia 74 9.67 169 157200 22724 64318639
Discomfort 70.86 9.67 56 157313 80822 64260541
Hypertensive crisis 70.76 9.67 145 157224 18103 64323260
Anaemia 70.74 9.67 1307 156062 377373 63963990
Wound 69.50 9.67 51 157318 76426 64264937
Blood loss anaemia 69.46 9.67 123 157246 13769 64327594
Computerised tomogram coronary artery abnormal 69.06 9.67 24 157345 184 64341179
Hypervolaemia 68.92 9.67 228 157141 38057 64303306
Left ventricular dilatation 68.49 9.67 37 157332 895 64340468
Glomerular filtration rate decreased 68.33 9.67 149 157220 19423 64321940
Ventricular hypokinesia 67.61 9.67 89 157280 7680 64333683
Coronary artery bypass 65.75 9.67 76 157293 5739 64335624
Duodenal ulcer perforation 65.37 9.67 5 157364 34620 64306743
Nasopharyngitis 65.02 9.67 252 157117 195821 64145542
Myocardial ischaemia 62.66 9.67 160 157209 23091 64318272
Orthopnoea 62.17 9.67 93 157276 9041 64332322
Cardioactive drug level increased 62.16 9.67 58 157311 3407 64337956
Presyncope 61.42 9.67 207 157162 34882 64306481
Infection 60.42 9.67 239 157130 184641 64156722
Ventricular arrhythmia 60.03 9.67 82 157287 7333 64334030
Arrhythmia 59.78 9.67 272 157097 52672 64288691
N-terminal prohormone brain natriuretic peptide increased 58.94 9.67 57 157312 3502 64337861
Peritonitis bacterial 58.61 9.67 90 157279 8953 64332410
Blood urea increased 58.44 9.67 238 157131 43915 64297448
Asthenia 57.44 9.67 1408 155961 426636 63914727
Drug interaction 57.27 9.67 1219 156150 360864 63980499
Helicobacter infection 56.97 9.67 12 157357 38350 64303013
Dehydration 56.91 9.67 792 156577 215971 64125392
Left ventricular dysfunction 55.73 9.67 126 157243 16828 64324535
Blood glucose increased 55.68 9.67 420 156949 97653 64243710
Diastolic dysfunction 55.66 9.67 87 157282 8788 64332575
Therapeutic product effect incomplete 55.43 9.67 105 157264 103377 64237986
Erythema 54.28 9.67 253 157116 186817 64154546
Exposure during pregnancy 53.95 9.67 66 157303 77609 64263754
Product use in unapproved indication 53.56 9.67 235 157134 176383 64164980
Angina unstable 53.15 9.67 117 157252 15350 64326013
Fluid retention 52.91 9.67 286 157083 59320 64282043
Cerebral infarction 52.55 9.67 219 157150 40825 64300538
Muscle injury 52.31 9.67 3 157366 26434 64314929
Shock 51.30 9.67 207 157162 38033 64303330
Haemorrhage intracranial 51.07 9.67 151 157218 23733 64317630
Glycosylated haemoglobin increased 50.39 9.67 117 157252 15902 64325461
Electrocardiogram abnormal 49.79 9.67 105 157264 13376 64327987
Mental status changes 48.69 9.67 285 157084 60877 64280486
Haemoglobin decreased 48.11 9.67 705 156664 194358 64147005
Leukopenia 48.09 9.67 110 157259 101132 64240231
Suicidal ideation 47.86 9.67 55 157314 66487 64274876
Serotonin syndrome 47.76 9.67 18 157351 39264 64302099
Folliculitis 47.67 9.67 8 157361 30069 64311294
N-terminal prohormone brain natriuretic peptide abnormal 46.66 9.67 19 157350 235 64341128
Subdural haematoma 45.18 9.67 161 157208 27893 64313470
Brain natriuretic peptide increased 43.99 9.67 72 157297 7561 64333802
Atrioventricular block complete 43.93 9.67 104 157265 14314 64327049
Upper gastrointestinal haemorrhage 43.59 9.67 186 157183 35034 64306329
Stomatitis 43.00 9.67 131 157238 109474 64231889
Cardio-respiratory arrest 42.34 9.67 396 156973 97997 64243366
Product use issue 41.21 9.67 210 157159 151505 64189858
Ventricular internal diameter abnormal 40.59 9.67 15 157354 140 64341223
Headache 40.58 9.67 983 156386 528484 63812879
End stage renal disease 40.33 9.67 83 157286 10392 64330971
Red blood cell sedimentation rate increased 40.23 9.67 13 157356 31222 64310141
Nephrogenic anaemia 40.21 9.67 45 157324 3280 64338083
Nodal rhythm 40.20 9.67 42 157327 2832 64338531
Atrioventricular block first degree 40.10 9.67 84 157285 10650 64330713
Injection site reaction 40.01 9.67 33 157336 46631 64294732
Urticaria 39.96 9.67 204 157165 147113 64194250
Blood pressure inadequately controlled 39.80 9.67 57 157312 5327 64336036
Spinal epidural haematoma 39.53 9.67 29 157340 1213 64340150
Arteriosclerosis 39.45 9.67 106 157263 15771 64325592
Ventricular fibrillation 38.48 9.67 137 157232 23723 64317640
Impaired healing 38.30 9.67 55 157314 60418 64280945
Hypovolaemia 38.09 9.67 103 157266 15383 64325980
Drug dependence 37.69 9.67 17 157352 33295 64308068
Sinus arrest 37.68 9.67 42 157327 3048 64338315
Malignant neoplasm progression 37.43 9.67 145 157224 112726 64228637
Unresponsive to stimuli 37.03 9.67 230 157139 50163 64291200
Gastrointestinal disorder 36.79 9.67 105 157264 89604 64251759
Pregnancy 36.74 9.67 4 157365 20861 64320502
Pulmonary valve disease 36.10 9.67 16 157353 247 64341116
Injection site erythema 36.04 9.67 74 157295 70726 64270637
Migraine 35.89 9.67 61 157308 62616 64278747
Intentional product use issue 35.28 9.67 117 157252 95247 64246116
Dialysis 35.25 9.67 106 157263 16814 64324549
Coronary artery occlusion 34.78 9.67 93 157276 13798 64327565
Sudden cardiac death 34.55 9.67 49 157320 4538 64336825
C-reactive protein abnormal 34.18 9.67 14 157355 29033 64312330
Ischaemic stroke 34.14 9.67 151 157218 28884 64312479
Ventricular extrasystoles 33.90 9.67 107 157262 17422 64323941
Sleep disorder due to general medical condition, insomnia type 33.72 9.67 11 157358 26259 64315104
Brain natriuretic peptide abnormal 33.68 9.67 21 157348 669 64340694
Agitation 33.68 9.67 107 157262 88260 64253103
Fibromyalgia 33.55 9.67 23 157346 35708 64305655
Implantable defibrillator insertion 33.47 9.67 22 157347 769 64340594
Injection site swelling 33.33 9.67 31 157338 41322 64300041
Abortion spontaneous 33.22 9.67 10 157359 25133 64316230
Suicide attempt 33.03 9.67 78 157291 70929 64270434
Pulmonary hypertension 33.03 9.67 199 157170 42940 64298423
Carotid sinus syndrome 32.89 9.67 10 157359 47 64341316
Type V hyperlipidaemia 32.72 9.67 23 157346 899 64340464
Drug reaction with eosinophilia and systemic symptoms 32.70 9.67 51 157318 54166 64287197
Suspected suicide 32.65 9.67 68 157301 8586 64332777
Bradyarrhythmia 32.62 9.67 43 157326 3715 64337648
Swelling 32.45 9.67 243 157126 159975 64181388
Cytomegalovirus infection 32.27 9.67 26 157343 37173 64304190
Oropharyngeal pain 32.21 9.67 110 157259 88757 64252606
Atrial flutter 31.88 9.67 112 157257 19268 64322095
Blood glucose decreased 31.67 9.67 126 157243 22997 64318366
Irritable bowel syndrome 31.33 9.67 27 157342 37342 64304021
Mobility decreased 31.29 9.67 106 157263 85734 64255629
Sedation 31.21 9.67 33 157336 41429 64299934
Intentional self-injury 31.06 9.67 16 157353 29028 64312335
Aortic valve incompetence 31.05 9.67 65 157304 8236 64333127
Torsade de pointes 30.89 9.67 103 157266 17260 64324103
Renal cyst haemorrhage 30.26 9.67 17 157352 445 64340918
Coma 30.06 9.67 111 157258 87504 64253859
Calcium deficiency 29.95 9.67 20 157349 718 64340645
Stenosis 29.93 9.67 29 157340 1786 64339577
Isosthenuria 29.92 9.67 11 157358 101 64341262
Melaena 29.64 9.67 228 157141 53320 64288043
Nodal arrhythmia 29.55 9.67 29 157340 1814 64339549
Rales 29.49 9.67 93 157276 15136 64326227
Intracardiac thrombus 29.39 9.67 41 157328 3740 64337623
Bone marrow failure 29.02 9.67 45 157324 47907 64293456
Loss of consciousness 28.98 9.67 516 156853 147849 64193514
Osteoporosis 28.96 9.67 36 157333 42044 64299319
Fall 28.90 9.67 1268 156101 415558 63925805
Pericardial disease 28.88 9.67 17 157352 487 64340876
Lower gastrointestinal haemorrhage 28.74 9.67 87 157282 13852 64327511
Inflammation 28.60 9.67 74 157295 65226 64276137
Vena cava injury 28.42 9.67 13 157356 217 64341146
Loss of personal independence in daily activities 28.12 9.67 87 157282 72367 64268996
Gastrointestinal tract mucosal pigmentation 28.06 9.67 21 157348 906 64340457
Embolic stroke 28.02 9.67 55 157314 6656 64334707
Cerebral haemorrhage 27.98 9.67 217 157152 50873 64290490
Mouth breathing 27.92 9.67 11 157358 124 64341239
Hepatocellular injury 27.80 9.67 42 157327 45193 64296170
Abdominal discomfort 27.53 9.67 298 157071 182024 64159339
Oral herpes 27.18 9.67 10 157359 22142 64319221
Neutrophil count decreased 27.01 9.67 97 157272 77099 64264264
Full blood count decreased 26.98 9.67 118 157251 22464 64318899
Blister 26.85 9.67 104 157265 80863 64260500
Pleural effusion 26.46 9.67 445 156924 126114 64215249
Renal injury 26.10 9.67 90 157279 15339 64326024
Renal artery stenosis 25.82 9.67 34 157335 2935 64338428
Asthma 25.74 9.67 132 157237 95093 64246270
Jugular vein distension 25.41 9.67 23 157346 1299 64340064
Azotaemia 24.93 9.67 56 157313 7446 64333917
Blood pressure fluctuation 24.92 9.67 56 157313 51815 64289548
Electrocardiogram QRS complex abnormal 24.89 9.67 16 157353 538 64340825
Plasma cell myeloma 24.84 9.67 195 157174 45880 64295483
Haematochezia 24.60 9.67 259 157110 66114 64275249
Pulse absent 24.56 9.67 62 157307 8884 64332479
Progressive multifocal leukoencephalopathy 24.54 9.67 7 157362 18225 64323138
Lymphadenopathy 24.44 9.67 48 157321 46638 64294725
Herpes zoster 24.20 9.67 105 157264 79082 64262281
Oedema 24.12 9.67 336 157033 91599 64249764
Rash maculo-papular 24.06 9.67 49 157320 46977 64294386
Physical examination abnormal 24.05 9.67 12 157357 245 64341118
Depression 24.04 9.67 309 157060 182982 64158381
Psoriatic arthropathy 23.98 9.67 43 157326 43238 64298125
Hyperparathyroidism secondary 23.94 9.67 29 157340 2301 64339062
Arthritis 23.91 9.67 114 157255 83700 64257663
Extradural haematoma 23.82 9.67 31 157338 2645 64338718
Dyspnoea exertional 23.81 9.67 280 157089 73450 64267913
Extrapyramidal disorder 23.70 9.67 9 157360 19543 64321820
Neuroleptic malignant syndrome 23.58 9.67 16 157353 24980 64316383
Acute respiratory failure 23.53 9.67 205 157164 49729 64291634
Haemophagocytic lymphohistiocytosis 23.27 9.67 7 157362 17602 64323761
Left ventricular hypertrophy 23.15 9.67 63 157306 9443 64331920
Orthostatic hypotension 23.14 9.67 194 157175 46544 64294819
Dyspnoea at rest 23.03 9.67 49 157320 6280 64335083
Acute pulmonary oedema 22.80 9.67 76 157293 12733 64328630
Poisoning deliberate 22.66 9.67 3 157366 13455 64327908
Injection site pruritus 22.41 9.67 36 157333 37790 64303573
Femoral artery dissection 22.35 9.67 7 157362 37 64341326
Hyperuricaemia 22.33 9.67 65 157304 10126 64331237
Mucosal inflammation 22.32 9.67 78 157291 62506 64278857
Cholestasis 21.92 9.67 48 157321 44824 64296539
Peripheral coldness 21.91 9.67 78 157291 13506 64327857
Therapy cessation 21.85 9.67 145 157224 32344 64309019
Multiple sclerosis relapse 21.79 9.67 42 157327 41093 64300270
Myelosuppression 21.50 9.67 16 157353 23814 64317549
Pulmonary congestion 21.47 9.67 115 157254 23765 64317598
Heart rate decreased 21.41 9.67 217 157152 54850 64286513
Pulmonary arterial pressure increased 21.30 9.67 37 157332 4079 64337284
Hypertensive emergency 21.25 9.67 27 157342 2249 64339114
Cardiac discomfort 21.04 9.67 19 157350 1070 64340293
Haematuria 21.03 9.67 233 157136 60238 64281125
Foot deformity 21.02 9.67 7 157362 16497 64324866
Rheumatoid nodule 20.88 9.67 3 157366 12648 64328715
Carotid artery stenosis 20.73 9.67 54 157315 7887 64333476
Device expulsion 20.66 9.67 13 157356 21123 64320240
Hydrothorax 20.57 9.67 20 157349 1237 64340126
Electrocardiogram PR shortened 20.55 9.67 11 157358 261 64341102
Tremor 20.52 9.67 247 157122 147983 64193380
Epstein-Barr virus infection 20.52 9.67 3 157366 12485 64328878
Conjunctival scar 20.48 9.67 8 157361 88 64341275
Pruritus 20.44 9.67 593 156776 311807 64029556
Vomiting 20.44 9.67 1118 156251 549999 63791364
Chronic obstructive pulmonary disease 20.43 9.67 264 157105 70784 64270579
Cardiac ventricular thrombosis 20.31 9.67 21 157348 1399 64339964
Neutrophil count increased 20.13 9.67 19 157350 25155 64316208
Anti-neutrophil cytoplasmic antibody positive vasculitis 20.13 9.67 30 157339 2906 64338457
Bundle branch block 20.06 9.67 21 157348 1419 64339944
Pericardial effusion 20 9.67 164 157205 39090 64302273
Pyelitis 19.93 9.67 11 157358 278 64341085
Bladder hypertrophy 19.85 9.67 14 157355 550 64340813
Cardiac tamponade 19.78 9.67 54 157315 8110 64333253
Osteonecrosis 19.58 9.67 24 157345 28205 64313158
Myxoedema coma 19.55 9.67 15 157354 672 64340691
Renal hypoplasia 19.30 9.67 5 157364 11 64341352
Neutropenic sepsis 19.28 9.67 17 157352 23255 64318108
Renal atrophy 19.24 9.67 22 157347 1642 64339721
Cardiac murmur 19.17 9.67 67 157302 11496 64329867
Tendonitis 19.11 9.67 13 157356 20269 64321094
Concomitant disease progression 19.06 9.67 31 157338 3238 64338125
Mitral valve thickening 19.06 9.67 12 157357 389 64340974
Fungal infection 19 9.67 34 157335 34217 64307146
Mania 18.92 9.67 8 157361 16278 64325085
Oxygen saturation increased 18.91 9.67 13 157356 490 64340873
Gastric cancer 18.88 9.67 46 157323 6447 64334916
Mitral valve calcification 18.81 9.67 20 157349 1376 64339987
C-reactive protein increased 18.71 9.67 145 157224 94764 64246599
Basal ganglia haemorrhage 18.69 9.67 20 157349 1386 64339977
SARS-CoV-2 antibody test positive 18.62 9.67 10 157359 239 64341124
Procedural hypotension 18.61 9.67 23 157346 1863 64339500
Bone erosion 18.56 9.67 3 157366 11592 64329771
Chills 18.51 9.67 230 157139 137034 64204329
Gout 18.49 9.67 102 157267 21311 64320052
Chronic left ventricular failure 18.49 9.67 15 157354 729 64340634
Conduction disorder 18.48 9.67 29 157340 2939 64338424
Blood thyroid stimulating hormone abnormal 18.46 9.67 15 157354 731 64340632
Cardiac pacemaker insertion 18.40 9.67 39 157330 4984 64336379
Dizziness postural 18.38 9.67 59 157310 9693 64331670
Carotid arteriosclerosis 18.38 9.67 24 157345 2055 64339308
Supraventricular tachycardia 18.34 9.67 93 157276 18814 64322549
Vessel puncture site haemorrhage 18.29 9.67 9 157360 178 64341185
Ventricular dysfunction 18.26 9.67 40 157329 5230 64336133
Pallor 18.16 9.67 159 157210 38622 64302741
Pulseless electrical activity 17.92 9.67 70 157299 12669 64328694
Internal haemorrhage 17.87 9.67 50 157319 7617 64333746
Gastrointestinal arteriovenous malformation 17.69 9.67 16 157353 903 64340460
Pulmonary arterial pressure abnormal 17.68 9.67 14 157355 657 64340706
Alanine aminotransferase increased 17.63 9.67 236 157133 138795 64202568
Pneumocystis jirovecii pneumonia 17.63 9.67 25 157344 27609 64313754
Lymphopenia 17.60 9.67 22 157347 25635 64315728
Gravitational oedema 17.49 9.67 21 157348 1651 64339712
Cognitive disorder 17.48 9.67 72 157297 55015 64286348
Bursitis 17.44 9.67 16 157353 21469 64319894
Shunt occlusion 17.28 9.67 18 157351 1209 64340154
Pulmonary renal syndrome 17.27 9.67 13 157356 566 64340797
Hip arthroplasty 17.21 9.67 16 157353 21335 64320028
Lymphocyte count decreased 17.15 9.67 47 157322 40652 64300711
Blood pressure diastolic abnormal 17.14 9.67 4 157365 11913 64329450
Transfusion 17.10 9.67 88 157281 17906 64323457
Fractured coccyx 17.00 9.67 16 157353 950 64340413
Glomerular filtration rate abnormal 16.90 9.67 18 157351 1241 64340122
Drug resistance 16.77 9.67 38 157331 35064 64306299
Mitral valve disease 16.74 9.67 26 157343 2612 64338751
Subarachnoid haemorrhage 16.72 9.67 89 157280 18349 64323014
Dilatation ventricular 16.50 9.67 32 157337 3838 64337525
Arterial spasm 16.46 9.67 8 157361 154 64341209
Cardiac aneurysm 16.43 9.67 18 157351 1281 64340082
Condition aggravated 16.41 9.67 742 156627 371684 63969679
Immune reconstitution inflammatory syndrome 16.40 9.67 5 157364 12465 64328898
Aortic stenosis 16.33 9.67 43 157326 6322 64335041
Ill-defined disorder 16.32 9.67 54 157315 43998 64297365
Drug ineffective for unapproved indication 16.30 9.67 32 157337 31101 64310262
Abdominal pain 16.17 9.67 611 156758 311764 64029599
Left atrial enlargement 16.11 9.67 16 157353 1016 64340347
Blood pressure systolic increased 16.09 9.67 64 157305 49389 64291974
Psychotic disorder 16.07 9.67 38 157331 34540 64306823
Dyspnoea paroxysmal nocturnal 15.98 9.67 22 157347 1982 64339381
Benign prostatic hyperplasia 15.97 9.67 54 157315 9111 64332252
Aplastic anaemia 15.91 9.67 7 157362 13913 64327450
Vascular graft 15.72 9.67 21 157348 1838 64339525
Peripheral vascular disorder 15.61 9.67 46 157323 7215 64334148
Mouth ulceration 15.60 9.67 35 157334 32409 64308954
Pulmonary embolism 15.59 9.67 257 157112 146099 64195264
Distributive shock 15.58 9.67 21 157348 1854 64339509
Oesophageal discomfort 15.54 9.67 9 157360 250 64341113
Blood pressure abnormal 15.43 9.67 73 157296 14362 64327001
Sinus node dysfunction 15.40 9.67 44 157325 6784 64334579
Gastritis erosive 15.39 9.67 55 157314 9540 64331823
Impaired work ability 15.38 9.67 9 157360 15210 64326153
Osteoarthritis 15.36 9.67 91 157278 63245 64278118
Dilatation atrial 15.29 9.67 29 157340 3421 64337942
Joint stiffness 15.28 9.67 32 157337 30372 64310991
Shunt thrombosis 15.24 9.67 7 157362 118 64341245
Gastric ulcer haemorrhage 15.10 9.67 49 157320 8094 64333269
Platelet dysfunction 15.08 9.67 10 157359 355 64341008
Electrocardiogram ST segment 15.06 9.67 3 157366 0 64341363
Renal disorder 15.03 9.67 142 157227 35223 64306140
Pericardial haemorrhage 15.02 9.67 32 157337 4104 64337259
Hypoglycaemic unconsciousness 15.00 9.67 16 157353 1105 64340258
Aggression 14.93 9.67 60 157309 46172 64295191
Sleep disorder 14.90 9.67 85 157284 59624 64281739
Therapeutic response decreased 14.87 9.67 71 157298 52117 64289246
Drug withdrawal syndrome 14.85 9.67 34 157335 31257 64310106
Ascites 14.83 9.67 223 157146 61778 64279585
Bronchiectasis 14.81 9.67 8 157361 14132 64327231
Creatinine renal clearance increased 14.73 9.67 14 157355 842 64340521
Inappropriate antidiuretic hormone secretion 14.70 9.67 99 157270 22190 64319173
Generalised tonic-clonic seizure 14.67 9.67 49 157320 39808 64301555
Gingival hypertrophy 14.61 9.67 25 157344 2722 64338641
Heart alternation 14.56 9.67 4 157365 12 64341351
Tachycardia induced cardiomyopathy 14.53 9.67 7 157362 132 64341231
Intercepted product dispensing error 14.53 9.67 7 157362 132 64341231
Coronary artery stenosis 14.38 9.67 60 157309 11188 64330175
Immunodeficiency 14.33 9.67 11 157358 16113 64325250
Non-compaction cardiomyopathy 14.31 9.67 5 157364 39 64341324
Hospice care 14.25 9.67 46 157323 7579 64333784
Body temperature increased 14.24 9.67 44 157325 36622 64304741
Hypoxic-ischaemic encephalopathy 14.15 9.67 44 157325 7108 64334255
Epilepsy 13.92 9.67 39 157330 33492 64307871
Urine output decreased 13.87 9.67 78 157291 16414 64324949
Arterial stenosis 13.84 9.67 17 157352 1368 64339995
Peripheral arterial occlusive disease 13.83 9.67 43 157326 6944 64334419
Subdural haemorrhage 13.78 9.67 36 157333 5267 64336096
Substance abuse 13.61 9.67 3 157366 9289 64332074
Uveitis 13.59 9.67 7 157362 12701 64328662
Joint effusion 13.57 9.67 8 157361 13465 64327898
Toxic goitre 13.48 9.67 4 157365 17 64341346
Candida infection 13.45 9.67 36 157333 31383 64309980
Unevaluable event 13.43 9.67 185 157184 50304 64291059
Faeces discoloured 13.38 9.67 108 157261 25621 64315742
Large intestinal haemorrhage 13.31 9.67 23 157346 2524 64338839
Pathogen resistance 13.28 9.67 7 157362 12536 64328827
Troponin I increased 13.23 9.67 29 157340 3792 64337571
Cardioactive drug level above therapeutic 13.20 9.67 8 157361 242 64341121
Diverticulum intestinal 13.18 9.67 44 157325 7376 64333987
Small intestinal haemorrhage 13.17 9.67 29 157340 3804 64337559
Epistaxis 13.16 9.67 323 157046 97808 64243555
Inspiratory capacity decreased 13.07 9.67 6 157363 101 64341262
Liver injury 13.04 9.67 34 157335 29898 64311465
Atrioventricular block second degree 13.04 9.67 40 157329 6414 64334949
Decreased appetite 13.03 9.67 824 156545 280465 64060898
Electrocardiogram T wave peaked 13.03 9.67 13 157356 830 64340533
Traumatic renal injury 12.98 9.67 3 157366 3 64341360
Pulmonary fibrosis 12.97 9.67 34 157335 29844 64311519
Haemorrhagic cerebral infarction 12.93 9.67 16 157353 1298 64340065
Aortic dissection 12.88 9.67 27 157342 3425 64337938
Symblepharon 12.86 9.67 7 157362 172 64341191
Rash erythematous 12.81 9.67 68 157301 48565 64292798
Injection site mass 12.71 9.67 14 157355 17256 64324107
Intraductal papillary mucinous neoplasm 12.70 9.67 11 157358 586 64340777
Seizure 12.68 9.67 310 157059 166582 64174781
Thrombocytopenia 12.65 9.67 433 156936 223368 64117995
Hypophagia 12.63 9.67 150 157219 39437 64301926
Rhabdomyolysis 12.62 9.67 303 157066 91423 64249940
Injection site bruising 12.52 9.67 46 157323 36327 64305036
Hepatorenal syndrome 12.49 9.67 28 157341 3718 64337645
Large intestine polyp 12.47 9.67 56 157313 10781 64330582
Peritonitis 12.45 9.67 104 157265 24919 64316444
Wheezing 12.43 9.67 131 157238 80448 64260915
Angioedema 12.41 9.67 216 157153 61605 64279758
Metastases to lymph nodes 12.39 9.67 3 157366 8714 64332649
Dyslipidaemia 12.37 9.67 50 157319 9192 64332171
Scrotal oedema 12.37 9.67 15 157354 1192 64340171
Fear 12.36 9.67 88 157281 20083 64321280
Pain in extremity 12.31 9.67 609 156760 302476 64038887
Toxicity to various agents 12.26 9.67 744 156625 362769 63978594
Hepatotoxicity 12.20 9.67 53 157316 39909 64301454
Injection site urticaria 12.20 9.67 6 157363 11175 64330188
Schizophrenia 12.17 9.67 6 157363 11162 64330201
Haematocrit decreased 12.09 9.67 194 157175 54461 64286902
Medication error 12.06 9.67 180 157189 49786 64291577
Rectal haemorrhage 12.06 9.67 215 157154 61602 64279761
Auditory disorder 12.01 9.67 9 157360 389 64340974
Tumour lysis syndrome 11.99 9.67 18 157351 19422 64321941
Gastrointestinal endoscopic therapy 11.99 9.67 5 157364 66 64341297
Oesophageal varices haemorrhage 11.96 9.67 27 157342 3602 64337761
Haemodialysis 11.96 9.67 77 157292 17000 64324363
Respiratory failure 11.95 9.67 494 156875 160689 64180674
Left atrial dilatation 11.95 9.67 23 157346 2743 64338620
Heart transplant 11.94 9.67 15 157354 1236 64340127
Paraesthesia 11.89 9.67 244 157125 134278 64207085
Ovarian cyst 11.89 9.67 6 157363 11012 64330351
Infective pulmonary exacerbation of cystic fibrosis 11.89 9.67 7 157362 11789 64329574
Tinnitus 11.86 9.67 43 157326 34090 64307273
Lacunar infarction 11.85 9.67 35 157334 5497 64335866
Low cardiac output syndrome 11.81 9.67 12 157357 783 64340580
Aortic aneurysm 11.80 9.67 43 157326 7531 64333832
Hypovolaemic shock 11.77 9.67 53 157316 10213 64331150
Haemorrhagic transformation stroke 11.75 9.67 21 157348 2368 64338995
Eye infection 11.71 9.67 4 157365 9277 64332086
Pulmonary valve incompetence 11.71 9.67 17 157352 1609 64339754
Beta 2 microglobulin urine increased 11.70 9.67 6 157363 130 64341233
Oliguria 11.64 9.67 68 157301 14508 64326855
Periodontitis 11.60 9.67 29 157340 4130 64337233
Blood cholesterol increased 11.58 9.67 73 157296 49993 64291370
Electrocardiogram QRS complex prolonged 11.58 9.67 49 157320 9195 64332168
Nipple swelling 11.46 9.67 3 157366 7 64341356
Panic attack 11.44 9.67 21 157348 20932 64320431
Renin increased 11.40 9.67 7 157362 217 64341146
Vascular stent stenosis 11.40 9.67 15 157354 1294 64340069
Ear pain 11.38 9.67 28 157341 25108 64316255
Cardiac operation 11.35 9.67 29 157340 4185 64337178
Neuropathy peripheral 11.35 9.67 210 157159 117315 64224048
Chest discomfort 11.33 9.67 367 157002 115739 64225624
Product monitoring error 11.20 9.67 34 157335 5420 64335943
Diabetes mellitus 11.18 9.67 226 157143 66248 64275115
Cardioversion 11.16 9.67 18 157351 1867 64339496
Pernicious anaemia 11.13 9.67 10 157359 559 64340804
Cardiac output decreased 11.10 9.67 17 157352 1687 64339676
Hypoglycaemic coma 11.09 9.67 29 157340 4245 64337118
Coagulation factor increased 11.06 9.67 5 157364 81 64341282
Bundle branch block right 11.03 9.67 52 157317 10217 64331146
Hypertension 11.02 9.67 754 156615 258507 64082856
Fistula 11.01 9.67 5 157364 9756 64331607
Activated partial thromboplastin time prolonged 11 9.67 61 157308 12770 64328593
Depressed mood 10.99 9.67 57 157312 40955 64300408
Dyskinesia 10.98 9.67 54 157315 39334 64302029
Panniculitis 10.91 9.67 4 157365 8875 64332488
Iron deficiency anaemia 10.91 9.67 91 157278 21798 64319565
Agranulocytosis 10.90 9.67 52 157317 38177 64303186
Hepatocellular carcinoma 10.88 9.67 45 157324 8358 64333005
Osteonecrosis of jaw 10.87 9.67 55 157314 39770 64301593
Hypoperfusion 10.75 9.67 20 157349 2326 64339037
Genotype drug resistance test positive 10.74 9.67 13 157356 1031 64340332
Rebound tachycardia 10.68 9.67 3 157366 10 64341353
Epinephrine increased 10.68 9.67 3 157366 10 64341353
Device breakage 10.66 9.67 4 157365 8751 64332612
Mood altered 10.65 9.67 14 157355 15965 64325398
Klebsiella infection 10.65 9.67 10 157359 13271 64328092
Post procedural hypothyroidism 10.64 9.67 5 157364 89 64341274
Miosis 10.62 9.67 10 157359 13256 64328107
Eczema 10.62 9.67 37 157332 29683 64311680
Acute coronary syndrome 10.56 9.67 82 157287 19228 64322135
Ejection fraction abnormal 10.50 9.67 15 157354 1398 64339965
Sciatica 10.46 9.67 21 157348 20243 64321120
International normalised ratio decreased 10.44 9.67 41 157328 7437 64333926
Diverticulum intestinal haemorrhagic 10.42 9.67 24 157345 3245 64338118
Blood aldosterone abnormal 10.41 9.67 4 157365 42 64341321
Cytokine release syndrome 10.40 9.67 22 157347 20807 64320556
Haemorrhagic stroke 10.40 9.67 50 157319 9901 64331462
Personality change 10.34 9.67 4 157365 8589 64332774
Neck pain 10.34 9.67 98 157271 61435 64279928
Thalamus haemorrhage 10.33 9.67 16 157353 1603 64339760
Injection site rash 10.28 9.67 14 157355 15728 64325635
Injection site haemorrhage 10.26 9.67 28 157341 24250 64317113
Blood cyanide increased 10.24 9.67 4 157365 44 64341319
Incarcerated hernia 10.22 9.67 8 157361 369 64340994
Hyperglycaemia 10.16 9.67 207 157162 60761 64280602
Hyperlipidaemia 10.14 9.67 93 157276 22883 64318480
Atrial tachycardia 10.12 9.67 25 157344 3534 64337829
Premature labour 10.12 9.67 3 157366 7617 64333746
Human ehrlichiosis 10.08 9.67 8 157361 377 64340986
Knee arthroplasty 10.07 9.67 33 157336 26966 64314397
Gangrene 10.06 9.67 40 157329 7298 64334065
Mucocutaneous haemorrhage 10.04 9.67 6 157363 177 64341186
Osteopenia 9.97 9.67 14 157355 15526 64325837
Toxic skin eruption 9.94 9.67 20 157349 19264 64322099
Idiopathic interstitial pneumonia 9.89 9.67 6 157363 182 64341181
Delusion 9.89 9.67 18 157351 17996 64323367
Blood sodium increased 9.87 9.67 28 157341 4298 64337065
Fungal peritonitis 9.84 9.67 12 157357 959 64340404
Thyroiditis 9.83 9.67 25 157344 3599 64337764
Injection site warmth 9.81 9.67 11 157358 13451 64327912
Traumatic haemothorax 9.81 9.67 8 157361 392 64340971
Tongue disorder 9.80 9.67 9 157360 12071 64329292
Hepatojugular reflux 9.80 9.67 9 157360 518 64340845
Device inappropriate shock delivery 9.78 9.67 4 157365 50 64341313
Coagulopathy 9.76 9.67 120 157249 31800 64309563
Pneumonia 9.76 9.67 1531 155838 558045 63783318
Exercise tolerance decreased 9.76 9.67 41 157328 7669 64333694
Photophobia 9.74 9.67 17 157352 17276 64324087
Haemorrhage subcutaneous 9.73 9.67 28 157341 4333 64337030
Musculoskeletal disorder 9.73 9.67 18 157351 17888 64323475
Extrasystoles 9.70 9.67 37 157332 6621 64334742
Carbohydrate antigen 15-3 increased 9.68 9.67 12 157357 975 64340388
Ventricular dyskinesia 9.67 9.67 8 157361 400 64340963

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
ATC C07AG02 CARDIOVASCULAR SYSTEM
BETA BLOCKING AGENTS
BETA BLOCKING AGENTS
Alpha and beta blocking agents
ATC C07FX06 CARDIOVASCULAR SYSTEM
BETA BLOCKING AGENTS
BETA BLOCKING AGENTS, OTHER COMBINATIONS
Beta blocking agents, other combinations
FDA MoA N0000000099 Adrenergic alpha-Antagonists
FDA MoA N0000009923 Adrenergic beta1-Antagonists
FDA MoA N0000009924 Adrenergic beta2-Antagonists
FDA EPC N0000175553 alpha-Adrenergic Blocker
FDA EPC N0000175556 beta-Adrenergic Blocker
CHEBI has role CHEBI:35530 beta-adrenergic blockers
CHEBI has role CHEBI:35554 cardiovascular agent
CHEBI has role CHEBI:35620 vasodilator agents
CHEBI has role CHEBI:35674 antihypertensive drugs
CHEBI has role CHEBI:37890 alpha-adrenergic receptor blockaders
MeSH PA D018663 Adrenergic Agents
MeSH PA D058668 Adrenergic alpha-1 Receptor Antagonists
MeSH PA D000317 Adrenergic alpha-Antagonists
MeSH PA D018674 Adrenergic Antagonists
MeSH PA D000319 Adrenergic beta-Antagonists
MeSH PA D000959 Antihypertensive Agents
MeSH PA D000975 Antioxidants
MeSH PA D002121 Calcium Channel Blockers
MeSH PA D000077264 Calcium-Regulating Hormones and Agents
MeSH PA D002317 Cardiovascular Agents
MeSH PA D049990 Membrane Transport Modulators
MeSH PA D018377 Neurotransmitter Agents
MeSH PA D020011 Protective Agents
MeSH PA D014665 Vasodilator Agents

Drug Use | Suggest Off label Use Form| |View source of the data|

DiseaseRelationSNOMED_IDDOID
Hypertensive disorder indication 38341003 DOID:10763
Chronic heart failure indication 48447003
Left ventricular cardiac dysfunction indication 429589006
Atrial fibrillation off-label use 49436004 DOID:0060224
Diastolic heart failure off-label use 418304008 DOID:9775
Prevention of Post Cardio-Thoracic Surgery Atrial Fibrillation off-label use
Bronchospasm contraindication 4386001
Complete atrioventricular block contraindication 27885002
Sick sinus syndrome contraindication 36083008 DOID:13884
Anaphylaxis contraindication 39579001
Low blood pressure contraindication 45007003
Sinus bradycardia contraindication 49710005
Hepatic failure contraindication 59927004
Chronic bronchitis contraindication 63480004 DOID:6132
Diabetes mellitus contraindication 73211009 DOID:9351
Prinzmetal angina contraindication 87343002
Pulmonary emphysema contraindication 87433001
Cardiogenic shock contraindication 89138009
Second degree atrioventricular block contraindication 195042002
Asthma contraindication 195967001 DOID:2841
Pregnancy, function contraindication 289908002
Peripheral vascular disease contraindication 400047006
Intraoperative floppy iris syndrome contraindication 418801006
Acutely Decompensated HF Requiring Parenteral Inotropic Therapy contraindication




๐Ÿถ Veterinary Drug Use

None

๐Ÿถ Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 12.13 acidic
pKa2 7.88 Basic

Orange Book patent data (new drug applications)

Formulation strengthTrade nameApplicantApplication numberApproval dateTypeDose formRoutePatent numberPatent expiration datePatent use
10MG COREG CR WOODWARD N022012 Oct. 20, 2006 RX CAPSULE, EXTENDED RELEASE ORAL 7268156 June 27, 2023 TREATMENT OF CONGESTIVE HEART FAILURE
10MG COREG CR WOODWARD N022012 Oct. 20, 2006 RX CAPSULE, EXTENDED RELEASE ORAL 7268156 June 27, 2023 TREATMENT OF HYPERTENSION
20MG COREG CR WOODWARD N022012 Oct. 20, 2006 RX CAPSULE, EXTENDED RELEASE ORAL 7268156 June 27, 2023 TREATMENT OF CONGESTIVE HEART FAILURE
20MG COREG CR WOODWARD N022012 Oct. 20, 2006 RX CAPSULE, EXTENDED RELEASE ORAL 7268156 June 27, 2023 TREATMENT OF HYPERTENSION
40MG COREG CR WOODWARD N022012 Oct. 20, 2006 RX CAPSULE, EXTENDED RELEASE ORAL 7268156 June 27, 2023 TREATMENT OF CONGESTIVE HEART FAILURE
40MG COREG CR WOODWARD N022012 Oct. 20, 2006 RX CAPSULE, EXTENDED RELEASE ORAL 7268156 June 27, 2023 TREATMENT OF HYPERTENSION
80MG COREG CR WOODWARD N022012 Oct. 20, 2006 RX CAPSULE, EXTENDED RELEASE ORAL 7268156 June 27, 2023 TREATMENT OF CONGESTIVE HEART FAILURE
80MG COREG CR WOODWARD N022012 Oct. 20, 2006 RX CAPSULE, EXTENDED RELEASE ORAL 7268156 June 27, 2023 TREATMENT OF HYPERTENSION

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
Beta-1 adrenergic receptor GPCR ANTAGONIST Ki 9.50 IUPHAR CHEMBL
Beta-2 adrenergic receptor GPCR ANTAGONIST Ki 9.90 IUPHAR CHEMBL
D(1A) dopamine receptor GPCR Ki 6.13 DRUG MATRIX
D(2) dopamine receptor GPCR Ki 7.31 DRUG MATRIX
Alpha-2A adrenergic receptor GPCR Ki 7.40 DRUG MATRIX
Potassium voltage-gated channel subfamily H member 2 Ion channel IC50 6.46 CHEMBL
Sodium-dependent serotonin transporter Transporter Ki 6.93 DRUG MATRIX
Sodium-dependent noradrenaline transporter Transporter Ki 6.27 DRUG MATRIX
5-hydroxytryptamine receptor 1A GPCR Ki 8.48 DRUG MATRIX
5-hydroxytryptamine receptor 2A GPCR Ki 6.93 DRUG MATRIX
5-hydroxytryptamine receptor 2B GPCR Ki 7.82 DRUG MATRIX
5-hydroxytryptamine receptor 2C GPCR Ki 7.22 DRUG MATRIX
5-hydroxytryptamine receptor 6 GPCR Ki 6.15 DRUG MATRIX
Alpha-1A adrenergic receptor GPCR ANTAGONIST Ki 8.66 WOMBAT-PK
Alpha-2B adrenergic receptor GPCR Ki 7.37 DRUG MATRIX
D(3) dopamine receptor GPCR Ki 6.71 DRUG MATRIX
Beta-3 adrenergic receptor GPCR ANTAGONIST Ki 9.40 IUPHAR
Alpha-2C adrenergic receptor GPCR Ki 7.89 DRUG MATRIX
Sodium-dependent dopamine transporter Transporter Ki 6.17 DRUG MATRIX
Alpha-1D adrenergic receptor GPCR ANTAGONIST Ki 9.05 DRUG MATRIX
Potassium channel subfamily K member 2 Ion channel IC50 5.80 CHEMBL
Solute carrier family 22 member 1 Transporter IC50 5.47 CHEMBL
Potassium channel subfamily K member 10 Ion channel IC50 5.12 CHEMBL
Solute carrier family 22 member 2 Transporter IC50 5.12 CHEMBL
Multidrug and toxin extrusion protein 1 Transporter IC50 4.03 CHEMBL
Toll-like receptor 4 Membrane receptor IC50 4.49 CHEMBL
Ryanodine receptor 2 Ion channel INHIBITOR IC50 4.80 IUPHAR
Amyloid beta A4 protein Unclassified IC50 4.52 CHEMBL
Alpha-1B adrenergic receptor GPCR Ki 8.71 DRUG MATRIX
5-hydroxytryptamine receptor 1B GPCR Ki 6.23 DRUG MATRIX
Alpha-1A adrenergic receptor GPCR IC50 8.11 CHEMBL
5-hydroxytryptamine receptor 1A GPCR Ki 8.50 CHEMBL
Beta-1 adrenergic receptor GPCR Ki 9.09 CHEMBL
5-hydroxytryptamine receptor 4 GPCR Ki 6.74 DRUG MATRIX

External reference:

IDSource
4021041 VUID
N0000148505 NUI
D00255 KEGG_DRUG
610309-89-2 SECONDARY_CAS_RN
20352 RXNORM
4021041 VANDF
4026028 VANDF
C0054836 UMLSCUI
CHEBI:3441 CHEBI
CVD PDB_CHEM_ID
CHEMBL723 ChEMBL_ID
CHEMBL1201167 ChEMBL_ID
D000077261 MESH_DESCRIPTOR_UI
DB01136 DRUGBANK_ID
2585 PUBCHEM_CID
551 IUPHAR_LIGAND_ID
5333 INN_ID
374779-41-6 SECONDARY_CAS_RN
0K47UL67F2 UNII
119032 MMSL
22339 MMSL
265288 MMSL
4363 MMSL
d03847 MMSL
004167 NDDF
011844 NDDF
108551001 SNOMEDCT_US
386870007 SNOMEDCT_US
426471008 SNOMEDCT_US

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
COREGCR HUMAN PRESCRIPTION DRUG LABEL 1 0007-3370 CAPSULE, EXTENDED RELEASE 10 mg ORAL NDA 26 sections
COREGCR HUMAN PRESCRIPTION DRUG LABEL 1 0007-3371 CAPSULE, EXTENDED RELEASE 20 mg ORAL NDA 26 sections
COREGCR HUMAN PRESCRIPTION DRUG LABEL 1 0007-3372 CAPSULE, EXTENDED RELEASE 40 mg ORAL NDA 26 sections
COREGCR HUMAN PRESCRIPTION DRUG LABEL 1 0007-3373 CAPSULE, EXTENDED RELEASE 80 mg ORAL NDA 26 sections
COREGCR HUMAN PRESCRIPTION DRUG LABEL 1 0007-3383 CAPSULE, EXTENDED RELEASE 10 mg ORAL NDA 26 sections
COREGCR HUMAN PRESCRIPTION DRUG LABEL 1 0007-3385 CAPSULE, EXTENDED RELEASE 20 mg ORAL NDA 26 sections
COREGCR HUMAN PRESCRIPTION DRUG LABEL 1 0007-3387 CAPSULE, EXTENDED RELEASE 40 mg ORAL NDA 26 sections
COREGCR HUMAN PRESCRIPTION DRUG LABEL 1 0007-3388 CAPSULE, EXTENDED RELEASE 80 mg ORAL NDA 26 sections
COREG HUMAN PRESCRIPTION DRUG LABEL 1 0007-4139 TABLET, FILM COATED 3.13 mg ORAL NDA 26 sections
COREG HUMAN PRESCRIPTION DRUG LABEL 1 0007-4140 TABLET, FILM COATED 6.25 mg ORAL NDA 26 sections
COREG HUMAN PRESCRIPTION DRUG LABEL 1 0007-4141 TABLET, FILM COATED 12.50 mg ORAL NDA 26 sections
COREG HUMAN PRESCRIPTION DRUG LABEL 1 0007-4142 TABLET, FILM COATED 25 mg ORAL NDA 26 sections
Carvedilol HUMAN PRESCRIPTION DRUG LABEL 1 0093-0051 TABLET, FILM COATED 3.13 mg ORAL ANDA 26 sections
Carvedilol HUMAN PRESCRIPTION DRUG LABEL 1 0093-0135 TABLET, FILM COATED 6.25 mg ORAL ANDA 26 sections
Carvedilol HUMAN PRESCRIPTION DRUG LABEL 1 0093-7295 TABLET, FILM COATED 12.50 mg ORAL ANDA 26 sections
Carvedilol HUMAN PRESCRIPTION DRUG LABEL 1 0093-7296 TABLET, FILM COATED 25 mg ORAL ANDA 26 sections
Carvedilol HUMAN PRESCRIPTION DRUG LABEL 1 0378-3631 TABLET, FILM COATED 3.13 mg ORAL ANDA 26 sections
Carvedilol HUMAN PRESCRIPTION DRUG LABEL 1 0378-3632 TABLET, FILM COATED 6.25 mg ORAL ANDA 26 sections
Carvedilol HUMAN PRESCRIPTION DRUG LABEL 1 0378-3633 TABLET, FILM COATED 12.50 mg ORAL ANDA 26 sections
Carvedilol HUMAN PRESCRIPTION DRUG LABEL 1 0378-3634 TABLET, FILM COATED 25 mg ORAL ANDA 26 sections
Carvedilol HUMAN PRESCRIPTION DRUG LABEL 1 0615-7944 TABLET, FILM COATED 3.13 mg ORAL ANDA 27 sections
Carvedilol HUMAN PRESCRIPTION DRUG LABEL 1 0615-7945 TABLET, FILM COATED 12.50 mg ORAL ANDA 27 sections
Carvedilol HUMAN PRESCRIPTION DRUG LABEL 1 0615-7946 TABLET, FILM COATED 25 mg ORAL ANDA 27 sections
Carvedilol HUMAN PRESCRIPTION DRUG LABEL 1 0615-8018 TABLET, FILM COATED 6.25 mg ORAL ANDA 27 sections
Carvedilol HUMAN PRESCRIPTION DRUG LABEL 1 0615-8387 TABLET, FILM COATED 3.13 mg ORAL ANDA 26 sections
Carvedilol HUMAN PRESCRIPTION DRUG LABEL 1 0615-8388 TABLET, FILM COATED 6.25 mg ORAL ANDA 26 sections
Carvedilol HUMAN PRESCRIPTION DRUG LABEL 1 0615-8389 TABLET, FILM COATED 12.50 mg ORAL ANDA 26 sections
Carvedilol HUMAN PRESCRIPTION DRUG LABEL 1 0615-8390 TABLET, FILM COATED 25 mg ORAL ANDA 26 sections
Carvedilol HUMAN PRESCRIPTION DRUG LABEL 1 0781-5221 TABLET, FILM COATED 3.13 mg ORAL ANDA 25 sections
Carvedilol HUMAN PRESCRIPTION DRUG LABEL 1 0781-5222 TABLET, FILM COATED 6.25 mg ORAL ANDA 25 sections