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carmofur 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | PK/Tox | Related Drugs | BioActivity |
| Stem definition | Drug id | CAS RN |
|---|---|---|
| uridine derivatives used as antiviral agents and as antineoplastics | 511 | 61422-45-5 |
Description:
| Molecule | Description |
|---|---|
|
Synonyms:
|
|
Drug dosage:
None
ADMET properties:
None
Predicted pharmacokinetic/toxicological properties (PK-AZ):
| Property | Description | Value | Unit | Confidence | Similarity |
|---|---|---|---|---|---|
| kinase-safety-class | ACVR2A,ACVR2B,ALK,AURKA,AXL,BRAF,BTK,CAMK2B,CAMK2D,CDK5,CDK9,CHEK1,CSF1R,DDR1,DYRK1B,EIF2AK3,ERBB2,FLT3,GRK2,GRK3,GSK3B,IGF1R,ITK,JAK1,JAK2,MAP3K21,MAP3K7,MAP4K1,MAPK7,MAPK9,MARK4,MTOR,NTRK2,PDK1,PDK2,PIK3CB,PIK3CD,PIM2,PLK1,PLK2,PLK3,PLK4,PRKCD,PRKDC,PTK2,SIK2,SIK3,STK33,TEK,TTK,ULK1,ULK2 | 52 | |||
| kinase-selectivity-class | AXL,BRAF,CAMK2D,CDK9,EPHB4,GRK2,MAPK12,MAPK7,PLK1,PLK2,PLK3,PLK4,SIK2,SIK3,STK33,TEK | 16 | |||
| pfas-class | PFAS structural alert (1 = True, 0 = False) | 0 |
Approvals:
None
FDA Adverse Event Reporting System (Female)
None
FDA Adverse Event Reporting System (Male)
None
FDA Adverse Event Reporting System (Geriatric)
None
FDA Adverse Event Reporting System (Pediatric)
None
Pharmacologic Action:
| Source | Code | Description |
|---|---|---|
| ATC | L01BC04 | ANTINEOPLASTIC AND IMMUNOMODULATING AGENTS ANTINEOPLASTIC AGENTS ANTIMETABOLITES Pyrimidine analogues |
| MeSH PA | D000970 | Antineoplastic Agents |
| CHEBI has role | CHEBI:35610 | antineoplastic agent |
Related Drugs by ATC class:
L01BC Pyrimidine analogues 9 drugs
Drug Use | Suggest Off label Use Form| |View source of the data|
| Disease | Relation | SNOMED_ID | DOID |
|---|---|---|---|
| Malignant tumor of colon | indication | 363406005 | DOID:219 |
🐶 Veterinary Drug Use
None
🐶 Veterinary products
None
Acid dissociation constants calculated using MoKa v3.0.0
| Dissociation level | Dissociation constant | Type (acidic/basic) |
|---|---|---|
| pKa1 | 6.55 | acidic |
| pKa2 | 13.95 | acidic |
Orange Book patent data (new drug applications)
None
Orange Book exclusivity data (new drug applications)
None
Bioactivity Summary:
| Target | Class | Pharos | UniProt | Action | Type | Activity value (-log[M]) | Mechanism action | Bioact source | MoA source |
|---|---|---|---|---|---|---|---|---|---|
| Cytochrome P450 2D6 | Enzyme | IC50 | 5.30 | DRUG MATRIX | |||||
| Mitogen-activated protein kinase 3 | Kinase | IC50 | 5.21 | DRUG MATRIX | |||||
| Acid ceramidase | Enzyme | IC50 | 7.68 | CHEMBL | |||||
| Sulfide:quinone oxidoreductase, mitochondrial | Enzyme | IC50 | 4.70 | CHEMBL | |||||
| Fatty-acid amide hydrolase 1 | Enzyme | IC50 | 7.60 | CHEMBL | |||||
| Acid ceramidase | Enzyme | IC50 | 7.54 | CHEMBL | |||||
| Replicase polyprotein 1ab | Enzyme | IC50 | 5.74 | CHEMBL |
External reference:
| ID | Source |
|---|---|
| D01784 | KEGG_DRUG |
| C0044401 | UMLSCUI |
| CHEBI:31360 | CHEBI |
| CHEMBL460499 | ChEMBL_ID |
| DB09010 | DRUGBANK_ID |
| C017367 | MESH_SUPPLEMENTAL_RECORD_UI |
| 2577 | PUBCHEM_CID |
| 5042 | INN_ID |
| HA82M3RAB2 | UNII |
| 010893 | NDDF |
Pharmaceutical products:
None