fluorouracil Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |
| Stem definition | Drug id | CAS RN |
|---|---|---|
| uracil type antineoplastics | 26 | 51-21-8 |
Description:
| Molecule | Description |
|---|---|
|
Synonyms:
|
A pyrimidine analog that is an antineoplastic antimetabolite. It interferes with DNA synthesis by blocking the THYMIDYLATE SYNTHETASE conversion of deoxyuridylic acid to thymidylic acid.
Legend: OFP - off patent OFM - off market ONP - on patent |
Drug dosage:
None
ADMET properties:
| Property | Value | Reference |
|---|---|---|
| BDDCS (Biopharmaceutical Drug Disposition Classification System) | 1 | Benet LZ, Broccatelli F, Oprea TI |
| S (Water solubility) | 12.20 mg/mL | Benet LZ, Broccatelli F, Oprea TI |
| EoM (Fraction excreted unchanged in urine) | 5 % | Benet LZ, Broccatelli F, Oprea TI |
| MRTD (Maximum Recommended Therapeutic Daily Dose) | 92.25 µM/kg/day | Contrera JF, Matthews EJ, Kruhlak NL, Benz RD |
| BA (Bioavailability) | 28 % | Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H |
| Vd (Volume of distribution) | 0.23 L/kg | Lombardo F, Berellini G, Obach RS |
| CL (Clearance) | 26 mL/min/kg | Lombardo F, Berellini G, Obach RS |
| fu (Fraction unbound in plasma) | 0.64 % | Lombardo F, Berellini G, Obach RS |
| t_half (Half-life) | 0.12 hours | Lombardo F, Berellini G, Obach RS |
Approvals:
| Date | Agency | Company | Orphan |
|---|---|---|---|
| April 25, 1962 | FDA | SPECTRUM PHARMS |
FDA Adverse Event Reporting System (Female)
| MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
|---|---|---|---|---|---|---|
| Neutropenia | 1554.48 | 13.08 | 1475 | 70713 | 141729 | 46472145 |
| Febrile neutropenia | 872.47 | 13.08 | 893 | 71295 | 93734 | 46520140 |
| Mucosal inflammation | 831.98 | 13.08 | 596 | 71592 | 38380 | 46575494 |
| Neuropathy peripheral | 604.10 | 13.08 | 723 | 71465 | 90170 | 46523704 |
| Diarrhoea | 579.38 | 13.08 | 2034 | 70154 | 557568 | 46056306 |
| Disease progression | 533.81 | 13.08 | 681 | 71507 | 90619 | 46523255 |
| Palmar-plantar erythrodysaesthesia syndrome | 495.06 | 13.08 | 338 | 71850 | 20113 | 46593761 |
| Thrombocytopenia | 439.27 | 13.08 | 738 | 71450 | 125843 | 46488031 |
| Leukopenia | 436.42 | 13.08 | 533 | 71655 | 67810 | 46546064 |
| Neurotoxicity | 425.82 | 13.08 | 265 | 71923 | 13452 | 46600422 |
| Stomatitis | 409.36 | 13.08 | 516 | 71672 | 67781 | 46546093 |
| Metastases to liver | 380.19 | 13.08 | 283 | 71905 | 19302 | 46594572 |
| Dermatitis acneiform | 370.66 | 13.08 | 162 | 72026 | 3908 | 46609966 |
| Malignant neoplasm progression | 350.68 | 13.08 | 466 | 71722 | 64460 | 46549414 |
| Drug ineffective | 325.45 | 13.08 | 343 | 71845 | 677495 | 45936379 |
| Bone marrow failure | 309.68 | 13.08 | 300 | 71888 | 29369 | 46584505 |
| Skin toxicity | 305.57 | 13.08 | 137 | 72051 | 3517 | 46610357 |
| Neoplasm progression | 295.92 | 13.08 | 279 | 71909 | 26404 | 46587470 |
| Metastases to lung | 264.04 | 13.08 | 179 | 72009 | 10517 | 46603357 |
| Vomiting | 260.49 | 13.08 | 1381 | 70807 | 451413 | 46162461 |
| Metastases to bone | 237.64 | 13.08 | 205 | 71983 | 17271 | 46596603 |
| Acute myeloid leukaemia | 230.77 | 13.08 | 193 | 71995 | 15585 | 46598289 |
| Neutrophil count decreased | 213.60 | 13.08 | 298 | 71890 | 43128 | 46570746 |
| Completed suicide | 210.01 | 13.08 | 3 | 72185 | 145917 | 46467957 |
| Posterior reversible encephalopathy syndrome | 200.59 | 13.08 | 175 | 72013 | 14966 | 46598908 |
| Product dose omission issue | 200.34 | 13.08 | 16 | 72172 | 168504 | 46445370 |
| Gastrointestinal toxicity | 199.06 | 13.08 | 108 | 72080 | 4223 | 46609651 |
| Breast cancer | 198.48 | 13.08 | 295 | 71893 | 45223 | 46568651 |
| Peripheral sensory neuropathy | 195.92 | 13.08 | 124 | 72064 | 6479 | 46607395 |
| Ejection fraction decreased | 188.30 | 13.08 | 182 | 72006 | 17755 | 46596119 |
| Metastasis | 182.96 | 13.08 | 102 | 72086 | 4210 | 46609664 |
| Gastrointestinal perforation | 177.99 | 13.08 | 91 | 72097 | 3146 | 46610728 |
| Polyneuropathy | 177.69 | 13.08 | 146 | 72042 | 11498 | 46602376 |
| Second primary malignancy | 176.50 | 13.08 | 116 | 72072 | 6468 | 46607406 |
| Haematotoxicity | 175.83 | 13.08 | 118 | 72070 | 6815 | 46607059 |
| Acute promyelocytic leukaemia | 173.41 | 13.08 | 62 | 72126 | 859 | 46613015 |
| Arthralgia | 172.51 | 13.08 | 186 | 72002 | 364417 | 46249457 |
| Fall | 170.48 | 13.08 | 155 | 72033 | 328942 | 46284932 |
| Pyrexia | 168.35 | 13.08 | 1016 | 71172 | 347786 | 46266088 |
| Joint swelling | 164.90 | 13.08 | 29 | 72159 | 166044 | 46447830 |
| Arteriospasm coronary | 162.83 | 13.08 | 89 | 72099 | 3532 | 46610342 |
| Colorectal cancer metastatic | 160.63 | 13.08 | 55 | 72133 | 665 | 46613209 |
| Cardiomyopathy | 159.22 | 13.08 | 158 | 72030 | 15915 | 46597959 |
| Cardiotoxicity | 157.63 | 13.08 | 109 | 72079 | 6613 | 46607261 |
| Hyperammonaemia | 156.22 | 13.08 | 95 | 72093 | 4621 | 46609253 |
| Headache | 151.08 | 13.08 | 322 | 71866 | 478030 | 46135844 |
| Laryngospasm | 149.99 | 13.08 | 78 | 72110 | 2795 | 46611079 |
| General physical health deterioration | 148.06 | 13.08 | 454 | 71734 | 115315 | 46498559 |
| Interstitial lung disease | 146.40 | 13.08 | 283 | 71905 | 53666 | 46560208 |
| Paronychia | 146.19 | 13.08 | 90 | 72098 | 4476 | 46609398 |
| Disease recurrence | 140.95 | 13.08 | 158 | 72030 | 18313 | 46595561 |
| Drug hypersensitivity | 138.30 | 13.08 | 105 | 72083 | 243720 | 46370154 |
| Nausea | 135.15 | 13.08 | 1637 | 70551 | 685817 | 45928057 |
| Neutropenic sepsis | 134.93 | 13.08 | 128 | 72060 | 12196 | 46601678 |
| Pulmonary embolism | 130.69 | 13.08 | 417 | 71771 | 108168 | 46505706 |
| Injection site pain | 127.78 | 13.08 | 10 | 72178 | 107142 | 46506732 |
| Metastases to lymph nodes | 126.80 | 13.08 | 95 | 72093 | 6536 | 46607338 |
| Dehydration | 123.34 | 13.08 | 531 | 71657 | 159009 | 46454865 |
| Weight increased | 123.28 | 13.08 | 50 | 72138 | 164423 | 46449451 |
| Proteinuria | 116.84 | 13.08 | 136 | 72052 | 16417 | 46597457 |
| Decreased appetite | 114.02 | 13.08 | 596 | 71592 | 193240 | 46420634 |
| Sinusitis | 111.96 | 13.08 | 31 | 72157 | 129737 | 46484137 |
| Abdominal discomfort | 106.86 | 13.08 | 50 | 72138 | 151115 | 46462759 |
| Nasopharyngitis | 104.23 | 13.08 | 54 | 72134 | 153944 | 46459930 |
| Hypomagnesaemia | 104.10 | 13.08 | 149 | 72039 | 22061 | 46591813 |
| Pain | 103.10 | 13.08 | 385 | 71803 | 476563 | 46137311 |
| Pain in extremity | 101.34 | 13.08 | 152 | 72036 | 258528 | 46355346 |
| Psoriasis | 100.68 | 13.08 | 5 | 72183 | 78599 | 46535275 |
| Depression | 100.62 | 13.08 | 70 | 72118 | 170034 | 46443840 |
| Abdominal pain | 97.59 | 13.08 | 649 | 71539 | 229382 | 46384492 |
| Anaemia | 93.51 | 13.08 | 696 | 71492 | 255083 | 46358791 |
| Paraesthesia | 91.55 | 13.08 | 392 | 71796 | 117045 | 46496829 |
| Large intestine perforation | 91.23 | 13.08 | 83 | 72105 | 7497 | 46606377 |
| Stress cardiomyopathy | 89.34 | 13.08 | 83 | 72105 | 7701 | 46606173 |
| Hypokalaemia | 85.66 | 13.08 | 315 | 71873 | 87709 | 46526165 |
| Systemic lupus erythematosus | 83.94 | 13.08 | 4 | 72184 | 65176 | 46548698 |
| Enteritis | 83.33 | 13.08 | 75 | 72113 | 6680 | 46607194 |
| Drug abuse | 81.31 | 13.08 | 4 | 72184 | 63404 | 46550470 |
| Peripheral swelling | 81.01 | 13.08 | 75 | 72113 | 157996 | 46455878 |
| Injection site erythema | 80.73 | 13.08 | 10 | 72178 | 74417 | 46539457 |
| Focal nodular hyperplasia | 79.56 | 13.08 | 29 | 72159 | 426 | 46613448 |
| Death | 79.48 | 13.08 | 830 | 71358 | 334718 | 46279156 |
| Contraindicated product administered | 79.21 | 13.08 | 14 | 72174 | 79933 | 46533941 |
| Adenocarcinoma of colon | 78.39 | 13.08 | 46 | 72142 | 2094 | 46611780 |
| Ileus | 77.44 | 13.08 | 102 | 72086 | 13962 | 46599912 |
| Colon cancer | 77.14 | 13.08 | 83 | 72105 | 9186 | 46604688 |
| Therapeutic product effect decreased | 76.52 | 13.08 | 17 | 72171 | 82584 | 46531290 |
| Influenza | 75.73 | 13.08 | 22 | 72166 | 89248 | 46524626 |
| Intestinal perforation | 74.65 | 13.08 | 88 | 72100 | 10763 | 46603111 |
| Neutropenic colitis | 74.02 | 13.08 | 45 | 72143 | 2187 | 46611687 |
| Extravasation | 73.65 | 13.08 | 44 | 72144 | 2071 | 46611803 |
| Hyperammonaemic encephalopathy | 73.65 | 13.08 | 43 | 72145 | 1939 | 46611935 |
| Portal hypertension | 73.59 | 13.08 | 53 | 72135 | 3430 | 46610444 |
| Anxiety | 73.07 | 13.08 | 105 | 72083 | 181852 | 46432022 |
| Hospitalisation | 72.59 | 13.08 | 7 | 72181 | 63378 | 46550496 |
| Drug interaction | 72.30 | 13.08 | 127 | 72061 | 202967 | 46410907 |
| Ascites | 71.53 | 13.08 | 168 | 72020 | 36416 | 46577458 |
| Myelosuppression | 71.29 | 13.08 | 73 | 72115 | 7630 | 46606244 |
| Bronchitis | 70.44 | 13.08 | 38 | 72150 | 105941 | 46507933 |
| Breast cancer recurrent | 70.29 | 13.08 | 54 | 72134 | 3857 | 46610017 |
| Musculoskeletal stiffness | 69.86 | 13.08 | 32 | 72156 | 97961 | 46515913 |
| Insomnia | 69.40 | 13.08 | 92 | 72096 | 164832 | 46449042 |
| Colon cancer metastatic | 69.12 | 13.08 | 35 | 72153 | 1185 | 46612689 |
| Breast cancer metastatic | 68.90 | 13.08 | 95 | 72093 | 13583 | 46600291 |
| Swelling | 68.75 | 13.08 | 55 | 72133 | 124456 | 46489418 |
| Migraine | 67.78 | 13.08 | 13 | 72175 | 70013 | 46543861 |
| Product use issue | 67.32 | 13.08 | 31 | 72157 | 94613 | 46519261 |
| Dihydropyrimidine dehydrogenase deficiency | 66.61 | 13.08 | 17 | 72171 | 64 | 46613810 |
| Left ventricular dysfunction | 65.36 | 13.08 | 80 | 72108 | 10175 | 46603699 |
| Pneumonia | 64.59 | 13.08 | 331 | 71857 | 375989 | 46237885 |
| Hypertransaminasaemia | 64.53 | 13.08 | 49 | 72139 | 3439 | 46610435 |
| Dizziness | 64.48 | 13.08 | 289 | 71899 | 340125 | 46273749 |
| Contusion | 63.25 | 13.08 | 28 | 72160 | 87459 | 46526415 |
| Metastases to pleura | 60.80 | 13.08 | 31 | 72157 | 1065 | 46612809 |
| Rectal perforation | 60.40 | 13.08 | 23 | 72165 | 384 | 46613490 |
| Arthritis | 60.38 | 13.08 | 22 | 72166 | 77294 | 46536580 |
| Arthropathy | 59.84 | 13.08 | 28 | 72160 | 84672 | 46529202 |
| Colorectal cancer | 59.06 | 13.08 | 29 | 72159 | 918 | 46612956 |
| Asthenia | 58.09 | 13.08 | 735 | 71453 | 310340 | 46303534 |
| Suicidal ideation | 57.79 | 13.08 | 9 | 72179 | 56373 | 46557501 |
| Feeling abnormal | 57.62 | 13.08 | 65 | 72123 | 124995 | 46488879 |
| Condition aggravated | 57.32 | 13.08 | 191 | 71997 | 244861 | 46369013 |
| Intentional product misuse | 57.30 | 13.08 | 4 | 72184 | 47124 | 46566750 |
| Osteoarthritis | 56.97 | 13.08 | 13 | 72175 | 62012 | 46551862 |
| Intestinal obstruction | 56.81 | 13.08 | 125 | 72063 | 25950 | 46587924 |
| Pruritus | 55.93 | 13.08 | 190 | 71998 | 242162 | 46371712 |
| Stress | 55.72 | 13.08 | 7 | 72181 | 51544 | 46562330 |
| Chronic obstructive pulmonary disease | 55.15 | 13.08 | 11 | 72177 | 57622 | 46556252 |
| Enterocutaneous fistula | 55.12 | 13.08 | 30 | 72158 | 1180 | 46612694 |
| Female genital tract fistula | 54.47 | 13.08 | 43 | 72145 | 3196 | 46610678 |
| Leukoencephalopathy | 54.47 | 13.08 | 47 | 72141 | 3957 | 46609917 |
| Pancytopenia | 54.42 | 13.08 | 268 | 71920 | 84790 | 46529084 |
| Subacute cutaneous lupus erythematosus | 54.41 | 13.08 | 35 | 72153 | 1880 | 46611994 |
| Carcinoembryonic antigen increased | 53.50 | 13.08 | 31 | 72157 | 1378 | 46612496 |
| Febrile bone marrow aplasia | 52.85 | 13.08 | 59 | 72129 | 6803 | 46607071 |
| Fluid retention | 52.65 | 13.08 | 8 | 72180 | 51038 | 46562836 |
| Device related thrombosis | 51.98 | 13.08 | 29 | 72159 | 1198 | 46612676 |
| Splenomegaly | 51.39 | 13.08 | 69 | 72119 | 9619 | 46604255 |
| Metastases to central nervous system | 50.71 | 13.08 | 74 | 72114 | 11147 | 46602727 |
| Cardiac failure | 49.79 | 13.08 | 250 | 71938 | 79698 | 46534176 |
| Dysarthria | 48.73 | 13.08 | 148 | 72040 | 37350 | 46576524 |
| Loss of personal independence in daily activities | 48.66 | 13.08 | 14 | 72174 | 57169 | 46556705 |
| Asthma | 48.59 | 13.08 | 42 | 72146 | 91500 | 46522374 |
| White blood cell count decreased | 48.28 | 13.08 | 318 | 71870 | 111913 | 46501961 |
| Disseminated intravascular coagulation | 48.25 | 13.08 | 97 | 72091 | 18908 | 46594966 |
| Congestive cardiomyopathy | 47.26 | 13.08 | 51 | 72137 | 5662 | 46608212 |
| Colony stimulating factor therapy | 47.19 | 13.08 | 18 | 72170 | 302 | 46613572 |
| Gait disturbance | 47.12 | 13.08 | 96 | 72092 | 145167 | 46468707 |
| Somnolence | 47 | 13.08 | 108 | 72080 | 156413 | 46457461 |
| Metastases to skin | 46.22 | 13.08 | 28 | 72160 | 1352 | 46612522 |
| Injection site reaction | 46.06 | 13.08 | 9 | 72179 | 47840 | 46566034 |
| Suicide attempt | 45.87 | 13.08 | 14 | 72174 | 55022 | 46558852 |
| Pemphigus | 44.68 | 13.08 | 8 | 72180 | 45266 | 46568608 |
| Mobility decreased | 44.42 | 13.08 | 19 | 72169 | 60575 | 46553299 |
| Metastases to peritoneum | 44.20 | 13.08 | 35 | 72153 | 2613 | 46611261 |
| Wound | 43.48 | 13.08 | 7 | 72181 | 42795 | 46571079 |
| Maternal exposure during pregnancy | 43.32 | 13.08 | 57 | 72131 | 102492 | 46511382 |
| Haemolytic anaemia | 43.16 | 13.08 | 64 | 72124 | 9778 | 46604096 |
| Overdose | 42.76 | 13.08 | 57 | 72131 | 101922 | 46511952 |
| Cholangitis | 42.72 | 13.08 | 44 | 72144 | 4630 | 46609244 |
| Myocarditis | 42.40 | 13.08 | 56 | 72132 | 7683 | 46606191 |
| Injection site swelling | 42.33 | 13.08 | 6 | 72182 | 40321 | 46573553 |
| Tumour perforation | 41.49 | 13.08 | 12 | 72176 | 79 | 46613795 |
| Peritonitis | 41.44 | 13.08 | 96 | 72092 | 20618 | 46593256 |
| Aortic thrombosis | 40.75 | 13.08 | 23 | 72165 | 972 | 46612902 |
| Cholinergic syndrome | 40.67 | 13.08 | 17 | 72171 | 366 | 46613508 |
| Malignant respiratory tract neoplasm | 40.42 | 13.08 | 11 | 72177 | 56 | 46613818 |
| Memory impairment | 40.41 | 13.08 | 36 | 72152 | 77301 | 46536573 |
| Abortion spontaneous | 40.38 | 13.08 | 9 | 72179 | 43637 | 46570237 |
| Steatohepatitis | 40.28 | 13.08 | 18 | 72170 | 458 | 46613416 |
| Chills | 40.03 | 13.08 | 270 | 71918 | 95762 | 46518112 |
| Haemolytic uraemic syndrome | 39.35 | 13.08 | 32 | 72156 | 2482 | 46611392 |
| Short-bowel syndrome | 39.15 | 13.08 | 17 | 72171 | 403 | 46613471 |
| Proctalgia | 38.26 | 13.08 | 42 | 72146 | 4754 | 46609120 |
| Troponin I increased | 38.07 | 13.08 | 28 | 72160 | 1872 | 46612002 |
| Balance disorder | 37.51 | 13.08 | 27 | 72161 | 64494 | 46549380 |
| Factor VII deficiency | 37.34 | 13.08 | 9 | 72179 | 25 | 46613849 |
| Injury | 37.05 | 13.08 | 11 | 72177 | 44016 | 46569858 |
| Embolism | 36.59 | 13.08 | 50 | 72138 | 7088 | 46606786 |
| Urticaria | 36.48 | 13.08 | 80 | 72108 | 117812 | 46496062 |
| Unevaluable event | 36.28 | 13.08 | 13 | 72175 | 46162 | 46567712 |
| Mucosal toxicity | 36.27 | 13.08 | 15 | 72173 | 314 | 46613560 |
| Rhabdomyolysis | 36.14 | 13.08 | 10 | 72178 | 41899 | 46571975 |
| Aortitis | 35.95 | 13.08 | 19 | 72169 | 704 | 46613170 |
| Incorrect dose administered | 35.49 | 13.08 | 13 | 72175 | 45537 | 46568337 |
| Wrong technique in product usage process | 35.44 | 13.08 | 20 | 72168 | 54402 | 46559472 |
| Renal salt-wasting syndrome | 35.41 | 13.08 | 13 | 72175 | 195 | 46613679 |
| Nasal congestion | 35.40 | 13.08 | 15 | 72173 | 48098 | 46565776 |
| Cataract | 35.32 | 13.08 | 13 | 72175 | 45402 | 46568472 |
| Immune thrombocytopenia | 35.30 | 13.08 | 53 | 72135 | 8188 | 46605686 |
| Cystitis radiation | 35.09 | 13.08 | 10 | 72178 | 62 | 46613812 |
| White blood cell count abnormal | 34.28 | 13.08 | 41 | 72147 | 5091 | 46608783 |
| Sleep disorder | 33.78 | 13.08 | 15 | 72173 | 46780 | 46567094 |
| Atypical haemolytic uraemic syndrome | 33.62 | 13.08 | 16 | 72172 | 472 | 46613402 |
| Bladder tamponade | 33.57 | 13.08 | 10 | 72178 | 74 | 46613800 |
| Nephritis bacterial | 33.52 | 13.08 | 8 | 72180 | 21 | 46613853 |
| Metastases to spine | 33.40 | 13.08 | 30 | 72158 | 2664 | 46611210 |
| Cough | 33.23 | 13.08 | 214 | 71974 | 230035 | 46383839 |
| Hypertensive crisis | 32.80 | 13.08 | 68 | 72120 | 13547 | 46600327 |
| Subileus | 32.50 | 13.08 | 31 | 72157 | 2972 | 46610902 |
| Organising pneumonia | 32.47 | 13.08 | 39 | 72149 | 4863 | 46609011 |
| Adverse drug reaction | 32.37 | 13.08 | 14 | 72174 | 44348 | 46569526 |
| Neuromyotonia | 32.27 | 13.08 | 9 | 72179 | 51 | 46613823 |
| Non-cirrhotic portal hypertension | 31.95 | 13.08 | 10 | 72178 | 89 | 46613785 |
| Deep vein thrombosis | 31.88 | 13.08 | 222 | 71966 | 79551 | 46534323 |
| Venous thrombosis | 31.73 | 13.08 | 38 | 72150 | 4724 | 46609150 |
| Product quality issue | 31.70 | 13.08 | 8 | 72180 | 35640 | 46578234 |
| Colitis | 31.66 | 13.08 | 128 | 72060 | 37219 | 46576655 |
| Urinary tract infection | 31.64 | 13.08 | 205 | 71983 | 220061 | 46393813 |
| Myelodysplastic syndrome | 31.63 | 13.08 | 73 | 72115 | 15638 | 46598236 |
| Treatment failure | 31.48 | 13.08 | 60 | 72128 | 93027 | 46520847 |
| Drug withdrawal syndrome | 31.41 | 13.08 | 3 | 72185 | 27381 | 46586493 |
| Large intestinal obstruction | 31.37 | 13.08 | 25 | 72163 | 1884 | 46611990 |
| Stridor | 31.27 | 13.08 | 31 | 72157 | 3116 | 46610758 |
| Hypertension | 31.23 | 13.08 | 451 | 71737 | 195905 | 46417969 |
| Fluid overload | 31.13 | 13.08 | 3 | 72185 | 27182 | 46586692 |
| Miller Fisher syndrome | 31.09 | 13.08 | 10 | 72178 | 98 | 46613776 |
| Venous pressure jugular decreased | 30.96 | 13.08 | 8 | 72180 | 32 | 46613842 |
| Skin fissures | 30.93 | 13.08 | 48 | 72140 | 7632 | 46606242 |
| Osteonecrosis of jaw | 30.85 | 13.08 | 120 | 72068 | 34282 | 46579592 |
| Trichomegaly | 30.77 | 13.08 | 8 | 72180 | 33 | 46613841 |
| Vena cava thrombosis | 30.50 | 13.08 | 26 | 72162 | 2153 | 46611721 |
| Gastrointestinal necrosis | 30.33 | 13.08 | 29 | 72159 | 2789 | 46611085 |
| Small intestinal obstruction | 30.23 | 13.08 | 73 | 72115 | 16099 | 46597775 |
| Agranulocytosis | 30.18 | 13.08 | 89 | 72099 | 22096 | 46591778 |
| Venoocclusive liver disease | 30.11 | 13.08 | 35 | 72153 | 4216 | 46609658 |
| Bradycardia | 29.93 | 13.08 | 35 | 72153 | 66263 | 46547611 |
| Liver abscess | 29.83 | 13.08 | 28 | 72160 | 2631 | 46611243 |
| Oesophageal fistula | 29.81 | 13.08 | 10 | 72178 | 113 | 46613761 |
| Malignant pleural effusion | 29.74 | 13.08 | 27 | 72161 | 2431 | 46611443 |
| Dermatitis | 29.69 | 13.08 | 67 | 72121 | 14141 | 46599733 |
| Tumour ulceration | 29.66 | 13.08 | 10 | 72178 | 115 | 46613759 |
| Plasma cell myeloma | 29.46 | 13.08 | 16 | 72172 | 44462 | 46569412 |
| Hypophagia | 29.42 | 13.08 | 106 | 72082 | 29200 | 46584674 |
| Dysaesthesia | 29.25 | 13.08 | 30 | 72158 | 3141 | 46610733 |
| Septic shock | 29.24 | 13.08 | 171 | 72017 | 57722 | 46556152 |
| Metastases to meninges | 29.05 | 13.08 | 24 | 72164 | 1903 | 46611971 |
| Hormone receptor positive breast cancer | 29.02 | 13.08 | 14 | 72174 | 426 | 46613448 |
| Nicotinic acid deficiency | 28.73 | 13.08 | 8 | 72180 | 45 | 46613829 |
| Epistaxis | 28.73 | 13.08 | 184 | 72004 | 64121 | 46549753 |
| Heart rate decreased | 28.44 | 13.08 | 7 | 72181 | 31716 | 46582158 |
| Thrombocytopenic purpura | 28.41 | 13.08 | 20 | 72168 | 1248 | 46612626 |
| Metastases to the mediastinum | 28.23 | 13.08 | 14 | 72174 | 453 | 46613421 |
| Upper respiratory tract infection | 28.21 | 13.08 | 34 | 72154 | 63522 | 46550352 |
| Glossodynia | 27.91 | 13.08 | 17 | 72171 | 44356 | 46569518 |
| Therapy cessation | 27.86 | 13.08 | 4 | 72184 | 26625 | 46587249 |
| Subclavian vein thrombosis | 27.85 | 13.08 | 23 | 72165 | 1823 | 46612051 |
| Rectal cancer | 27.68 | 13.08 | 23 | 72165 | 1839 | 46612035 |
| Device related infection | 27.29 | 13.08 | 83 | 72105 | 20958 | 46592916 |
| Hydrothorax | 27.15 | 13.08 | 15 | 72173 | 608 | 46613266 |
| Emotional distress | 27.09 | 13.08 | 7 | 72181 | 30700 | 46583174 |
| Electrocardiogram QT prolonged | 26.68 | 13.08 | 24 | 72164 | 51301 | 46562573 |
| Conjunctival filtering bleb leak | 26.61 | 13.08 | 6 | 72182 | 11 | 46613863 |
| No adverse event | 26.28 | 13.08 | 10 | 72178 | 34221 | 46579653 |
| Metastases to reproductive organ | 26.27 | 13.08 | 6 | 72182 | 12 | 46613862 |
| Rectal cancer recurrent | 26.17 | 13.08 | 7 | 72181 | 33 | 46613841 |
| Tumour lysis syndrome | 26.09 | 13.08 | 43 | 72145 | 7193 | 46606681 |
| Gastrooesophageal reflux disease | 25.95 | 13.08 | 47 | 72141 | 74297 | 46539577 |
| Wheezing | 25.40 | 13.08 | 27 | 72161 | 53359 | 46560515 |
| Drug intolerance | 25.33 | 13.08 | 129 | 72059 | 146920 | 46466954 |
| Multiple sclerosis | 25.30 | 13.08 | 4 | 72184 | 24787 | 46589087 |
| Hypocapnia | 25.00 | 13.08 | 12 | 72176 | 361 | 46613513 |
| Hyperbilirubinaemia | 24.99 | 13.08 | 52 | 72136 | 10386 | 46603488 |
| Ocular toxicity | 24.94 | 13.08 | 13 | 72175 | 468 | 46613406 |
| ECG signs of myocardial ischaemia | 24.91 | 13.08 | 8 | 72180 | 78 | 46613796 |
| Blood creatine increased | 24.82 | 13.08 | 33 | 72155 | 4557 | 46609317 |
| Inferior vena cava stenosis | 24.81 | 13.08 | 6 | 72182 | 17 | 46613857 |
| Irritability | 24.78 | 13.08 | 7 | 72181 | 28939 | 46584935 |
| Soft tissue necrosis | 24.20 | 13.08 | 12 | 72176 | 388 | 46613486 |
| Diabetes mellitus | 24.18 | 13.08 | 25 | 72163 | 50040 | 46563834 |
| Jugular vein thrombosis | 24.16 | 13.08 | 25 | 72163 | 2645 | 46611229 |
| Tumour necrosis | 24.11 | 13.08 | 15 | 72173 | 760 | 46613114 |
| Coronary artery disease | 24.07 | 13.08 | 11 | 72177 | 33741 | 46580133 |
| Hepatic enzyme increased | 24.07 | 13.08 | 57 | 72131 | 81730 | 46532144 |
| Hepatic failure | 24.06 | 13.08 | 109 | 72079 | 33307 | 46580567 |
| Hallucination | 24.06 | 13.08 | 25 | 72163 | 49926 | 46563948 |
| Full blood count decreased | 24.04 | 13.08 | 3 | 72185 | 22208 | 46591666 |
| Vision blurred | 23.90 | 13.08 | 55 | 72133 | 79653 | 46534221 |
| Palpitations | 23.80 | 13.08 | 72 | 72116 | 95187 | 46518687 |
| Encephalopathy | 23.76 | 13.08 | 109 | 72079 | 33480 | 46580394 |
| Hyperkalaemia | 23.73 | 13.08 | 26 | 72162 | 50683 | 46563191 |
| Xerosis | 23.63 | 13.08 | 14 | 72174 | 649 | 46613225 |
| Biliary tract infection | 23.49 | 13.08 | 12 | 72176 | 414 | 46613460 |
| Tympanic membrane disorder | 23.49 | 13.08 | 9 | 72179 | 153 | 46613721 |
| Acute lymphocytic leukaemia | 23.37 | 13.08 | 25 | 72163 | 2748 | 46611126 |
| Acute leukaemia | 23.32 | 13.08 | 17 | 72171 | 1121 | 46612753 |
| Anastomotic leak | 23.23 | 13.08 | 12 | 72176 | 424 | 46613450 |
| Acute interstitial pneumonitis | 23.11 | 13.08 | 14 | 72174 | 676 | 46613198 |
| Sepsis | 23.05 | 13.08 | 316 | 71872 | 135698 | 46478176 |
| Aplasia | 22.95 | 13.08 | 28 | 72160 | 3548 | 46610326 |
| Fistula | 22.91 | 13.08 | 43 | 72145 | 7967 | 46605907 |
| Ear infection | 22.85 | 13.08 | 4 | 72184 | 23009 | 46590865 |
| Catabolic state | 22.81 | 13.08 | 7 | 72181 | 58 | 46613816 |
| Therapy partial responder | 22.80 | 13.08 | 32 | 72156 | 4650 | 46609224 |
| Throat tightness | 22.75 | 13.08 | 77 | 72111 | 20562 | 46593312 |
| Sedation | 22.71 | 13.08 | 4 | 72184 | 22906 | 46590968 |
| Metastases to ovary | 22.70 | 13.08 | 11 | 72177 | 338 | 46613536 |
| Aortic intramural haematoma | 22.70 | 13.08 | 7 | 72181 | 59 | 46613815 |
| Gastrointestinal stoma complication | 22.62 | 13.08 | 19 | 72169 | 1542 | 46612332 |
| Hepatic lesion | 22.60 | 13.08 | 29 | 72159 | 3868 | 46610006 |
| Dry skin | 22.59 | 13.08 | 124 | 72064 | 40892 | 46572982 |
| Superior vena cava syndrome | 22.55 | 13.08 | 13 | 72175 | 572 | 46613302 |
| Aggression | 22.48 | 13.08 | 4 | 72184 | 22740 | 46591134 |
| Stomatitis haemorrhagic | 22.48 | 13.08 | 6 | 72182 | 28 | 46613846 |
| Cardiac ventricular thrombosis | 22.35 | 13.08 | 12 | 72176 | 459 | 46613415 |
| Psychotic disorder | 22.31 | 13.08 | 4 | 72184 | 22617 | 46591257 |
| Aortic dissection | 22.29 | 13.08 | 19 | 72169 | 1573 | 46612301 |
| Amnesia | 22.20 | 13.08 | 19 | 72169 | 41612 | 46572262 |
| Tumour haemorrhage | 22.12 | 13.08 | 18 | 72170 | 1397 | 46612477 |
| Xerophthalmia | 21.90 | 13.08 | 10 | 72178 | 268 | 46613606 |
| Nasal septum perforation | 21.88 | 13.08 | 14 | 72174 | 745 | 46613129 |
| Visual impairment | 21.67 | 13.08 | 44 | 72144 | 66645 | 46547229 |
| Gastrointestinal stoma output increased | 21.60 | 13.08 | 9 | 72179 | 192 | 46613682 |
| Myocardial ischaemia | 21.16 | 13.08 | 55 | 72133 | 12694 | 46601180 |
| Head injury | 21.01 | 13.08 | 6 | 72182 | 24630 | 46589244 |
| Device issue | 20.90 | 13.08 | 3 | 72185 | 19977 | 46593897 |
| Cardiomyopathy acute | 20.90 | 13.08 | 9 | 72179 | 209 | 46613665 |
| Type 2 diabetes mellitus | 20.76 | 13.08 | 3 | 72185 | 19872 | 46594002 |
| Cachexia | 20.75 | 13.08 | 31 | 72157 | 4768 | 46609106 |
| Hepatic vein stenosis | 20.71 | 13.08 | 5 | 72183 | 14 | 46613860 |
| Pregnancy | 20.71 | 13.08 | 8 | 72180 | 27129 | 46586745 |
| Tonic clonic movements | 20.66 | 13.08 | 16 | 72172 | 1156 | 46612718 |
| Red blood cell sedimentation rate increased | 20.61 | 13.08 | 5 | 72183 | 22884 | 46590990 |
| Oesophageal carcinoma | 20.60 | 13.08 | 14 | 72174 | 825 | 46613049 |
| Bone marrow infiltration | 20.58 | 13.08 | 11 | 72177 | 417 | 46613457 |
| Liver function test abnormal | 20.49 | 13.08 | 25 | 72163 | 46462 | 46567412 |
| Neutrophil count abnormal | 20.49 | 13.08 | 22 | 72166 | 2428 | 46611446 |
| Gait apraxia | 20.46 | 13.08 | 5 | 72183 | 15 | 46613859 |
| Pigmentation disorder | 20.43 | 13.08 | 27 | 72161 | 3706 | 46610168 |
| Foot fracture | 20.35 | 13.08 | 3 | 72185 | 19579 | 46594295 |
| Carbohydrate antigen 19-9 increased | 20.30 | 13.08 | 8 | 72180 | 147 | 46613727 |
| Duodenal perforation | 20.30 | 13.08 | 14 | 72174 | 845 | 46613029 |
| Gastric disorder | 20.17 | 13.08 | 8 | 72180 | 26697 | 46587177 |
| Platelet count decreased | 20.17 | 13.08 | 240 | 71948 | 99784 | 46514090 |
| Gait inability | 20.11 | 13.08 | 15 | 72173 | 35188 | 46578686 |
| Muscle spasms | 20.08 | 13.08 | 110 | 72078 | 123003 | 46490871 |
| Portal vein dilatation | 19.99 | 13.08 | 5 | 72183 | 17 | 46613857 |
| HER2 positive breast cancer | 19.98 | 13.08 | 7 | 72181 | 91 | 46613783 |
| Confusional state | 19.92 | 13.08 | 155 | 72033 | 159737 | 46454137 |
| International normalised ratio increased | 19.85 | 13.08 | 26 | 72162 | 46857 | 46567017 |
| Eczema herpeticum | 19.84 | 13.08 | 7 | 72181 | 93 | 46613781 |
| Heart rate increased | 19.80 | 13.08 | 55 | 72133 | 74736 | 46539138 |
| Blood glucose increased | 19.78 | 13.08 | 52 | 72136 | 71961 | 46541913 |
| Dyskinesia | 19.75 | 13.08 | 10 | 72178 | 28915 | 46584959 |
| Pulmonary fistula | 19.66 | 13.08 | 4 | 72184 | 3 | 46613871 |
| Blood phosphorus decreased | 19.62 | 13.08 | 27 | 72161 | 3853 | 46610021 |
| Herpes zoster | 19.42 | 13.08 | 48 | 72140 | 67824 | 46546050 |
| Wound decomposition | 19.35 | 13.08 | 5 | 72183 | 20 | 46613854 |
| Treatment noncompliance | 19.25 | 13.08 | 11 | 72177 | 29720 | 46584154 |
| Myeloproliferative neoplasm | 19.17 | 13.08 | 11 | 72177 | 480 | 46613394 |
| Protein urine | 19.14 | 13.08 | 12 | 72176 | 616 | 46613258 |
| Electrocardiogram ST segment elevation | 19.11 | 13.08 | 26 | 72162 | 3669 | 46610205 |
| Nodular regenerative hyperplasia | 18.99 | 13.08 | 9 | 72179 | 263 | 46613611 |
| Nephrolithiasis | 18.99 | 13.08 | 14 | 72174 | 33037 | 46580837 |
| Acute abdomen | 18.87 | 13.08 | 17 | 72171 | 1515 | 46612359 |
| Oesophagitis | 18.79 | 13.08 | 55 | 72133 | 13596 | 46600278 |
| Drug level increased | 18.76 | 13.08 | 3 | 72185 | 18438 | 46595436 |
| Recurrent cancer | 18.74 | 13.08 | 18 | 72170 | 1741 | 46612133 |
| Blood pressure fluctuation | 18.69 | 13.08 | 12 | 72176 | 30436 | 46583438 |
| Lymphangiosis carcinomatosa | 18.61 | 13.08 | 15 | 72173 | 1149 | 46612725 |
| Tumour marker increased | 18.44 | 13.08 | 25 | 72163 | 3516 | 46610358 |
| Withdrawal syndrome | 18.34 | 13.08 | 3 | 72185 | 18131 | 46595743 |
| Blood creatine phosphokinase increased | 18.32 | 13.08 | 10 | 72178 | 27714 | 46586160 |
| Chronic villitis of unknown etiology | 18.24 | 13.08 | 4 | 72184 | 6 | 46613868 |
| Dysgeusia | 18.16 | 13.08 | 116 | 72072 | 40375 | 46573499 |
| Cardiac arrest | 18.12 | 13.08 | 75 | 72113 | 90324 | 46523550 |
| Radiation skin injury | 18.01 | 13.08 | 13 | 72175 | 844 | 46613030 |
| Anal inflammation | 17.95 | 13.08 | 7 | 72181 | 125 | 46613749 |
| Myalgia | 17.94 | 13.08 | 114 | 72074 | 122974 | 46490900 |
| Pelvic fluid collection | 17.76 | 13.08 | 13 | 72175 | 863 | 46613011 |
| Proctitis | 17.75 | 13.08 | 17 | 72171 | 1638 | 46612236 |
| Vesical fistula | 17.64 | 13.08 | 6 | 72182 | 71 | 46613803 |
| Respiratory failure | 17.60 | 13.08 | 224 | 71964 | 94592 | 46519282 |
| Pelvic abscess | 17.57 | 13.08 | 16 | 72172 | 1446 | 46612428 |
| Splenic marginal zone lymphoma recurrent | 17.51 | 13.08 | 4 | 72184 | 8 | 46613866 |
| Recall phenomenon | 17.51 | 13.08 | 11 | 72177 | 567 | 46613307 |
| Diaphragmatic paralysis | 17.40 | 13.08 | 11 | 72177 | 573 | 46613301 |
| Device dislocation | 17.36 | 13.08 | 6 | 72182 | 21796 | 46592078 |
| Respiratory arrest | 17.35 | 13.08 | 16 | 72172 | 33800 | 46580074 |
| Rib fracture | 17.35 | 13.08 | 4 | 72184 | 18950 | 46594924 |
| Vitamin B1 deficiency | 17.26 | 13.08 | 8 | 72180 | 222 | 46613652 |
| Intercepted product administration error | 17.20 | 13.08 | 6 | 72182 | 77 | 46613797 |
| K-ras gene mutation | 17.19 | 13.08 | 4 | 72184 | 9 | 46613865 |
| Portal shunt | 17.19 | 13.08 | 4 | 72184 | 9 | 46613865 |
| Cutaneous tuberculosis | 17.17 | 13.08 | 7 | 72181 | 141 | 46613733 |
| Lymphadenopathy mediastinal | 17.17 | 13.08 | 20 | 72168 | 2414 | 46611460 |
| Gastric perforation | 17.14 | 13.08 | 15 | 72173 | 1287 | 46612587 |
| Osteonecrosis | 17.08 | 13.08 | 82 | 72106 | 25662 | 46588212 |
| Wernicke's encephalopathy | 17.02 | 13.08 | 5 | 72183 | 35 | 46613839 |
| Productive cough | 16.87 | 13.08 | 33 | 72155 | 50682 | 46563192 |
| Metastases to chest wall | 16.87 | 13.08 | 10 | 72178 | 464 | 46613410 |
| Depressed mood | 16.82 | 13.08 | 16 | 72172 | 33303 | 46580571 |
| Surgery | 16.79 | 13.08 | 12 | 72176 | 28773 | 46585101 |
| Ocular vasculitis | 16.78 | 13.08 | 5 | 72183 | 37 | 46613837 |
| Neck pain | 16.71 | 13.08 | 38 | 72150 | 55268 | 46558606 |
| Osteoporosis | 16.70 | 13.08 | 23 | 72165 | 40585 | 46573289 |
| Chemotherapy | 16.65 | 13.08 | 15 | 72173 | 1337 | 46612537 |
| Endocardial fibrosis | 16.62 | 13.08 | 4 | 72184 | 11 | 46613863 |
| Pneumatosis intestinalis | 16.61 | 13.08 | 18 | 72170 | 2007 | 46611867 |
| Localised infection | 16.60 | 13.08 | 8 | 72180 | 23793 | 46590081 |
| Lower respiratory tract infection | 16.52 | 13.08 | 38 | 72150 | 55051 | 46558823 |
| Mental disorder | 16.48 | 13.08 | 7 | 72181 | 22418 | 46591456 |
| Hiatus hernia | 16.48 | 13.08 | 4 | 72184 | 18298 | 46595576 |
| SAPHO syndrome | 16.47 | 13.08 | 6 | 72182 | 88 | 46613786 |
| Road traffic accident | 16.47 | 13.08 | 8 | 72180 | 23683 | 46590191 |
| Endometrial dysplasia | 16.37 | 13.08 | 4 | 72184 | 12 | 46613862 |
| Nail disorder | 16.24 | 13.08 | 37 | 72151 | 7859 | 46606015 |
| Multiple organ dysfunction syndrome | 16.22 | 13.08 | 136 | 72052 | 51574 | 46562300 |
| Hypocalcaemia | 16.13 | 13.08 | 83 | 72105 | 26702 | 46587172 |
| Dandy-Walker syndrome | 16.11 | 13.08 | 6 | 72182 | 94 | 46613780 |
| Tongue oedema | 16.08 | 13.08 | 25 | 72163 | 3981 | 46609893 |
| Adenocarcinoma | 16.01 | 13.08 | 19 | 72169 | 2340 | 46611534 |
| Dry eye | 15.97 | 13.08 | 14 | 72174 | 30308 | 46583566 |
| Blood count abnormal | 15.92 | 13.08 | 4 | 72184 | 17874 | 46596000 |
| Aorto-oesophageal fistula | 15.90 | 13.08 | 4 | 72184 | 14 | 46613860 |
| Eosinophilia | 15.81 | 13.08 | 5 | 72183 | 19212 | 46594662 |
| Menopause | 15.81 | 13.08 | 18 | 72170 | 2121 | 46611753 |
| Pulmonary toxicity | 15.74 | 13.08 | 27 | 72161 | 4666 | 46609208 |
| Hypophosphataemia | 15.68 | 13.08 | 35 | 72153 | 7332 | 46606542 |
| Small intestinal perforation | 15.67 | 13.08 | 14 | 72174 | 1234 | 46612640 |
| Metastases to neck | 15.64 | 13.08 | 5 | 72183 | 48 | 46613826 |
| Anaemia of malignant disease | 15.64 | 13.08 | 9 | 72179 | 395 | 46613479 |
| Performance status decreased | 15.58 | 13.08 | 22 | 72166 | 3215 | 46610659 |
| Metastases to breast | 15.58 | 13.08 | 8 | 72180 | 279 | 46613595 |
| Pulmonary fibrosis | 15.57 | 13.08 | 67 | 72121 | 20025 | 46593849 |
| Adverse event | 15.48 | 13.08 | 18 | 72170 | 34166 | 46579708 |
| Back pain | 15.47 | 13.08 | 230 | 71958 | 209809 | 46404065 |
| Vaginal fistula | 15.47 | 13.08 | 9 | 72179 | 403 | 46613471 |
| Colon cancer recurrent | 15.46 | 13.08 | 5 | 72183 | 50 | 46613824 |
| Hydronephrosis | 15.36 | 13.08 | 38 | 72150 | 8507 | 46605367 |
| Fistula of small intestine | 15.32 | 13.08 | 8 | 72180 | 289 | 46613585 |
| Hypermetabolism | 15.24 | 13.08 | 6 | 72182 | 110 | 46613764 |
| Agitation | 15.23 | 13.08 | 40 | 72148 | 55375 | 46558499 |
| Restless legs syndrome | 15.20 | 13.08 | 3 | 72185 | 15840 | 46598034 |
| Monoparesis | 15.20 | 13.08 | 15 | 72173 | 1500 | 46612374 |
| Hyperpyrexia | 15.13 | 13.08 | 20 | 72168 | 2746 | 46611128 |
| Herpes simplex encephalitis | 15.12 | 13.08 | 8 | 72180 | 297 | 46613577 |
| Hypoglycaemia | 15.11 | 13.08 | 39 | 72149 | 54310 | 46559564 |
| Enterocolitis | 15.08 | 13.08 | 31 | 72157 | 6137 | 46607737 |
| Left ventricular dilatation | 15.07 | 13.08 | 8 | 72180 | 299 | 46613575 |
| Night sweats | 15.07 | 13.08 | 12 | 72176 | 27238 | 46586636 |
| Systolic dysfunction | 15.06 | 13.08 | 14 | 72174 | 1300 | 46612574 |
| Carbohydrate antigen 15-3 increased | 14.97 | 13.08 | 12 | 72176 | 912 | 46612962 |
| Gastroenteropancreatic neuroendocrine tumour disease | 14.95 | 13.08 | 5 | 72183 | 56 | 46613818 |
| Facial discomfort | 14.93 | 13.08 | 4 | 72184 | 19 | 46613855 |
| Marchiafava-Bignami disease | 14.93 | 13.08 | 4 | 72184 | 19 | 46613855 |
| Acute coronary syndrome | 14.90 | 13.08 | 42 | 72146 | 10162 | 46603712 |
| Sopor | 14.88 | 13.08 | 6 | 72182 | 19822 | 46594052 |
| Red blood cell nucleated morphology present | 14.76 | 13.08 | 4 | 72184 | 20 | 46613854 |
| Ankle fracture | 14.75 | 13.08 | 3 | 72185 | 15508 | 46598366 |
| Multiple-drug resistance | 14.73 | 13.08 | 19 | 72169 | 2546 | 46611328 |
| Hypothyroidism | 14.73 | 13.08 | 16 | 72172 | 31322 | 46582552 |
| Off label use | 14.72 | 13.08 | 723 | 71465 | 379118 | 46234756 |
| Intracardiac thrombus | 14.70 | 13.08 | 18 | 72170 | 2290 | 46611584 |
| Oesophageal stenosis | 14.67 | 13.08 | 20 | 72168 | 2829 | 46611045 |
| Acute polyneuropathy | 14.63 | 13.08 | 7 | 72181 | 209 | 46613665 |
| Venous thrombosis limb | 14.59 | 13.08 | 20 | 72168 | 2843 | 46611031 |
| Skin exfoliation | 14.55 | 13.08 | 94 | 72094 | 32844 | 46581030 |
| Nasal crusting | 14.54 | 13.08 | 7 | 72181 | 212 | 46613662 |
| Anal erosion | 14.44 | 13.08 | 4 | 72184 | 22 | 46613852 |
| Percussion test abnormal | 14.35 | 13.08 | 3 | 72185 | 3 | 46613871 |
| Tumour obstruction | 14.35 | 13.08 | 3 | 72185 | 3 | 46613871 |
| Stoma site haemorrhage | 14.33 | 13.08 | 12 | 72176 | 970 | 46612904 |
| Blood pressure systolic increased | 14.32 | 13.08 | 14 | 72174 | 28773 | 46585101 |
| Cardiac myxoma | 14.30 | 13.08 | 7 | 72181 | 220 | 46613654 |
| Toxic cardiomyopathy | 14.27 | 13.08 | 6 | 72182 | 131 | 46613743 |
| Administration site extravasation | 14.26 | 13.08 | 10 | 72178 | 620 | 46613254 |
| Toxic encephalopathy | 14.26 | 13.08 | 27 | 72161 | 5035 | 46608839 |
| Joint range of motion decreased | 14.23 | 13.08 | 3 | 72185 | 15121 | 46598753 |
| Musculoskeletal pain | 14.16 | 13.08 | 58 | 72130 | 70070 | 46543804 |
| Pleural effusion | 14.15 | 13.08 | 193 | 71995 | 82759 | 46531115 |
| Discomfort | 14.15 | 13.08 | 32 | 72156 | 46638 | 46567236 |
| Skin disorder | 14.12 | 13.08 | 70 | 72118 | 22193 | 46591681 |
| Necrosis | 14.10 | 13.08 | 26 | 72162 | 4754 | 46609120 |
| Rash | 14.05 | 13.08 | 432 | 71756 | 356080 | 46257794 |
| Oesophageal varices haemorrhage | 13.95 | 13.08 | 13 | 72175 | 1210 | 46612664 |
| Periodontal disease | 13.94 | 13.08 | 15 | 72173 | 1660 | 46612214 |
| Cholelithiasis | 13.90 | 13.08 | 24 | 72164 | 38657 | 46575217 |
| T-cell type acute leukaemia | 13.87 | 13.08 | 5 | 72183 | 71 | 46613803 |
| Duodenal obstruction | 13.82 | 13.08 | 7 | 72181 | 237 | 46613637 |
| Chronic myeloid leukaemia | 13.80 | 13.08 | 18 | 72170 | 2440 | 46611434 |
| Portal vein thrombosis | 13.74 | 13.08 | 18 | 72170 | 2449 | 46611425 |
| Vascular pain | 13.74 | 13.08 | 10 | 72178 | 658 | 46613216 |
| Rash pustular | 13.73 | 13.08 | 32 | 72156 | 6897 | 46606977 |
| Erythema | 13.73 | 13.08 | 303 | 71885 | 142517 | 46471357 |
| Hypertensive encephalopathy | 13.70 | 13.08 | 10 | 72178 | 661 | 46613213 |
| Oral pain | 13.67 | 13.08 | 75 | 72113 | 24722 | 46589152 |
| Gallbladder disorder | 13.62 | 13.08 | 5 | 72183 | 17493 | 46596381 |
| Metastases to bone marrow | 13.61 | 13.08 | 7 | 72181 | 245 | 46613629 |
| Viral infection | 13.60 | 13.08 | 16 | 72172 | 30219 | 46583655 |
| Malignant neoplasm of pleura | 13.56 | 13.08 | 5 | 72183 | 76 | 46613798 |
| Metastases to abdominal wall | 13.56 | 13.08 | 5 | 72183 | 76 | 46613798 |
| Peripheral nerve injury | 13.54 | 13.08 | 8 | 72180 | 369 | 46613505 |
| Tremor | 13.52 | 13.08 | 114 | 72074 | 115525 | 46498349 |
| Systemic infection | 13.43 | 13.08 | 10 | 72178 | 681 | 46613193 |
| Spinal cord compression | 13.43 | 13.08 | 22 | 72166 | 3662 | 46610212 |
| Enterocolitis infectious | 13.39 | 13.08 | 14 | 72174 | 1499 | 46612375 |
| Pneumothorax spontaneous | 13.37 | 13.08 | 9 | 72179 | 522 | 46613352 |
| Accidental exposure to product | 13.36 | 13.08 | 8 | 72180 | 21073 | 46592801 |
| Bursitis | 13.34 | 13.08 | 7 | 72181 | 19835 | 46594039 |
| Red cell fragmentation syndrome | 13.27 | 13.08 | 4 | 72184 | 31 | 46613843 |
| Product intolerance | 13.27 | 13.08 | 4 | 72184 | 31 | 46613843 |
| Gingival atrophy | 13.27 | 13.08 | 4 | 72184 | 31 | 46613843 |
| Encapsulating peritoneal sclerosis | 13.25 | 13.08 | 8 | 72180 | 384 | 46613490 |
| Chronic kidney disease | 13.24 | 13.08 | 27 | 72161 | 40844 | 46573030 |
| Haemolysis | 13.14 | 13.08 | 29 | 72159 | 6030 | 46607844 |
| Optic disc hyperaemia | 13.13 | 13.08 | 3 | 72185 | 6 | 46613868 |
| Lhermitte's sign | 13.13 | 13.08 | 3 | 72185 | 6 | 46613868 |
| Periportal sinus dilatation | 13.13 | 13.08 | 3 | 72185 | 6 | 46613868 |
| Type II hypersensitivity | 13.13 | 13.08 | 3 | 72185 | 6 | 46613868 |
| Scintillating scotoma | 13.13 | 13.08 | 6 | 72182 | 161 | 46613713 |
| Pulmonary artery thrombosis | 13.12 | 13.08 | 10 | 72178 | 706 | 46613168 |
| Cerebral infarction | 13.10 | 13.08 | 71 | 72117 | 23295 | 46590579 |
FDA Adverse Event Reporting System (Male)
| MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
|---|---|---|---|---|---|---|
| Neutropenia | 1137.12 | 13.60 | 1555 | 79062 | 126985 | 29744876 |
| Diarrhoea | 936.45 | 13.60 | 2466 | 78151 | 331637 | 29540224 |
| Dermatitis acneiform | 814.94 | 13.60 | 367 | 80250 | 5322 | 29866539 |
| Mucosal inflammation | 737.94 | 13.60 | 630 | 79987 | 29864 | 29841997 |
| Neuropathy peripheral | 706.73 | 13.60 | 908 | 79709 | 69567 | 29802294 |
| Stomatitis | 623.99 | 13.60 | 627 | 79990 | 36652 | 29835209 |
| Disease progression | 512.65 | 13.60 | 833 | 79784 | 79041 | 29792820 |
| Arteriospasm coronary | 486.51 | 13.60 | 203 | 80414 | 2415 | 29869446 |
| Palmar-plantar erythrodysaesthesia syndrome | 458.30 | 13.60 | 354 | 80263 | 14516 | 29857345 |
| Skin toxicity | 447.52 | 13.60 | 204 | 80413 | 3045 | 29868816 |
| Paronychia | 401.98 | 13.60 | 185 | 80432 | 2826 | 29869035 |
| Thrombocytopenia | 378.80 | 13.60 | 1010 | 79607 | 136034 | 29735827 |
| Interstitial lung disease | 378.06 | 13.60 | 622 | 79995 | 59575 | 29812286 |
| Metastases to liver | 366.84 | 13.60 | 284 | 80333 | 11681 | 29860180 |
| Neurotoxicity | 342.59 | 13.60 | 284 | 80333 | 12898 | 29858963 |
| Leukopenia | 315.14 | 13.60 | 552 | 80065 | 55607 | 29816254 |
| Nausea | 286.83 | 13.60 | 1561 | 79056 | 295396 | 29576465 |
| Decreased appetite | 281.05 | 13.60 | 964 | 79653 | 148946 | 29722915 |
| Febrile neutropenia | 252.74 | 13.60 | 744 | 79873 | 105949 | 29765912 |
| Peripheral sensory neuropathy | 249.03 | 13.60 | 170 | 80447 | 5731 | 29866130 |
| Vomiting | 244.00 | 13.60 | 1202 | 79415 | 218616 | 29653245 |
| Completed suicide | 239.42 | 13.60 | 6 | 80611 | 99486 | 29772375 |
| Cardiotoxicity | 224.77 | 13.60 | 143 | 80474 | 4271 | 29867590 |
| Drug ineffective | 224.66 | 13.60 | 357 | 80260 | 340030 | 29531831 |
| Hyperammonaemia | 214.11 | 13.60 | 151 | 80466 | 5369 | 29866492 |
| Colorectal cancer metastatic | 211.04 | 13.60 | 85 | 80532 | 917 | 29870944 |
| Gastrointestinal perforation | 206.48 | 13.60 | 126 | 80491 | 3490 | 29868371 |
| Proteinuria | 205.33 | 13.60 | 235 | 80382 | 15910 | 29855951 |
| Bone marrow failure | 204.86 | 13.60 | 321 | 80296 | 29464 | 29842397 |
| Colorectal cancer | 199.67 | 13.60 | 97 | 80520 | 1682 | 29870179 |
| Metastases to lung | 198.68 | 13.60 | 167 | 80450 | 7728 | 29864133 |
| Gastrointestinal toxicity | 194.34 | 13.60 | 99 | 80518 | 1909 | 29869952 |
| Drug interaction | 189.16 | 13.60 | 156 | 80461 | 199412 | 29672449 |
| Hyperammonaemic encephalopathy | 175.81 | 13.60 | 90 | 80527 | 1754 | 29870107 |
| Dehydration | 168.16 | 13.60 | 718 | 79899 | 122821 | 29749040 |
| Arthralgia | 164.45 | 13.60 | 80 | 80537 | 135711 | 29736150 |
| Hypomagnesaemia | 161.42 | 13.60 | 211 | 80406 | 16387 | 29855474 |
| Polyneuropathy | 158.69 | 13.60 | 177 | 80440 | 11646 | 29860215 |
| Neutrophil count decreased | 156.41 | 13.60 | 350 | 80267 | 42104 | 29829757 |
| General physical health deterioration | 150.21 | 13.60 | 599 | 80018 | 99345 | 29772516 |
| Product dose omission issue | 149.56 | 13.60 | 32 | 80585 | 91599 | 29780262 |
| Intestinal obstruction | 146.11 | 13.60 | 217 | 80400 | 18995 | 29852866 |
| Alopecia | 145.57 | 13.60 | 217 | 80400 | 19058 | 29852803 |
| Carcinoembryonic antigen increased | 132.97 | 13.60 | 54 | 80563 | 596 | 29871265 |
| Headache | 132.79 | 13.60 | 178 | 80439 | 182128 | 29689733 |
| Fall | 129.02 | 13.60 | 181 | 80436 | 181691 | 29690170 |
| Abdominal pain | 123.40 | 13.60 | 703 | 79914 | 134951 | 29736910 |
| Skin reaction | 122.77 | 13.60 | 100 | 80517 | 4425 | 29867436 |
| Portal venous gas | 122.13 | 13.60 | 42 | 80575 | 278 | 29871583 |
| Pulmonary embolism | 115.48 | 13.60 | 466 | 80151 | 77669 | 29794192 |
| Pneumatosis intestinalis | 114.68 | 13.60 | 78 | 80539 | 2612 | 29869249 |
| Portal hypertension | 114.48 | 13.60 | 90 | 80527 | 3783 | 29868078 |
| Cardiac failure congestive | 112.82 | 13.60 | 43 | 80574 | 84364 | 29787497 |
| Rhabdomyolysis | 106.21 | 13.60 | 21 | 80596 | 63559 | 29808302 |
| Anxiety | 104.17 | 13.60 | 56 | 80561 | 89815 | 29782046 |
| Pyrexia | 103.43 | 13.60 | 1228 | 79389 | 293261 | 29578600 |
| Myalgia | 100.89 | 13.60 | 40 | 80577 | 76627 | 29795234 |
| Paraesthesia | 100.22 | 13.60 | 348 | 80269 | 53979 | 29817882 |
| Somnolence | 92.29 | 13.60 | 75 | 80542 | 96688 | 29775173 |
| Depression | 91.47 | 13.60 | 66 | 80551 | 90371 | 29781490 |
| Haematotoxicity | 90.84 | 13.60 | 97 | 80520 | 6073 | 29865788 |
| Weight increased | 90.80 | 13.60 | 44 | 80573 | 74869 | 29796992 |
| Neoplasm progression | 90.54 | 13.60 | 169 | 80448 | 17854 | 29854007 |
| Malignant neoplasm progression | 88.98 | 13.60 | 408 | 80209 | 71879 | 29799982 |
| Ileus | 88.53 | 13.60 | 154 | 80463 | 15401 | 29856460 |
| Pain in extremity | 88.16 | 13.60 | 100 | 80517 | 110121 | 29761740 |
| Psoriasis | 87.92 | 13.60 | 7 | 80610 | 42499 | 29829362 |
| Hospitalisation | 87.10 | 13.60 | 9 | 80608 | 44310 | 29827551 |
| Enteritis | 84.93 | 13.60 | 97 | 80520 | 6548 | 29865313 |
| Large intestine perforation | 83.44 | 13.60 | 103 | 80514 | 7548 | 29864313 |
| Hiccups | 82.64 | 13.60 | 114 | 80503 | 9320 | 29862541 |
| Oesophageal fistula | 82.64 | 13.60 | 28 | 80589 | 176 | 29871685 |
| Aggression | 82.54 | 13.60 | 4 | 80613 | 36903 | 29834958 |
| Ileal perforation | 82.15 | 13.60 | 40 | 80577 | 697 | 29871164 |
| Insomnia | 81.01 | 13.60 | 79 | 80538 | 93257 | 29778604 |
| Pelvic abscess | 80.85 | 13.60 | 43 | 80574 | 909 | 29870952 |
| Extravasation | 80.30 | 13.60 | 54 | 80563 | 1774 | 29870087 |
| Toxicity to various agents | 80.29 | 13.60 | 229 | 80388 | 176954 | 29694907 |
| Chills | 79.39 | 13.60 | 395 | 80222 | 71943 | 29799918 |
| Rheumatoid arthritis | 79.35 | 13.60 | 9 | 80608 | 41188 | 29830673 |
| Death | 78.95 | 13.60 | 601 | 80016 | 356682 | 29515179 |
| Necrotising fasciitis | 78.71 | 13.60 | 69 | 80548 | 3380 | 29868481 |
| Pneumonia | 76.87 | 13.60 | 556 | 80061 | 333750 | 29538111 |
| Intentional product misuse | 76.76 | 13.60 | 4 | 80613 | 34663 | 29837198 |
| Small intestinal obstruction | 76.13 | 13.60 | 134 | 80483 | 13525 | 29858336 |
| Colon cancer | 76.11 | 13.60 | 103 | 80514 | 8269 | 29863592 |
| Peritonitis | 75.08 | 13.60 | 173 | 80444 | 21202 | 29850659 |
| Suicidal ideation | 74.54 | 13.60 | 6 | 80611 | 36108 | 29835753 |
| Anastomotic complication | 73.94 | 13.60 | 29 | 80588 | 290 | 29871571 |
| Leukoencephalopathy | 73.69 | 13.60 | 71 | 80546 | 3931 | 29867930 |
| Hallucination | 72.51 | 13.60 | 21 | 80596 | 49038 | 29822823 |
| Overdose | 72.47 | 13.60 | 72 | 80545 | 84265 | 29787596 |
| Asthma | 71.99 | 13.60 | 7 | 80610 | 36167 | 29835694 |
| Aorto-oesophageal fistula | 70.99 | 13.60 | 18 | 80599 | 30 | 29871831 |
| Chronic obstructive pulmonary disease | 69.55 | 13.60 | 19 | 80598 | 46107 | 29825754 |
| Peripheral swelling | 69.37 | 13.60 | 39 | 80578 | 61035 | 29810826 |
| Electrocardiogram ST segment elevation | 69.25 | 13.60 | 72 | 80545 | 4370 | 29867491 |
| Subileus | 68.93 | 13.60 | 61 | 80556 | 3026 | 29868835 |
| Hypokalaemia | 68.32 | 13.60 | 292 | 80325 | 49900 | 29821961 |
| Colon cancer metastatic | 67.45 | 13.60 | 47 | 80570 | 1638 | 29870223 |
| Device related infection | 66.83 | 13.60 | 144 | 80473 | 16871 | 29854990 |
| Metastases to lymph nodes | 66.61 | 13.60 | 67 | 80550 | 3910 | 29867951 |
| Dermatitis | 66.29 | 13.60 | 95 | 80522 | 8047 | 29863814 |
| Blood glucose increased | 66.08 | 13.60 | 42 | 80575 | 61488 | 29810373 |
| Ascites | 65.26 | 13.60 | 229 | 80388 | 35692 | 29836169 |
| Focal nodular hyperplasia | 65.11 | 13.60 | 22 | 80595 | 137 | 29871724 |
| Small intestinal perforation | 64.78 | 13.60 | 46 | 80571 | 1653 | 29870208 |
| Septic shock | 63.97 | 13.60 | 339 | 80278 | 63268 | 29808593 |
| Anastomotic leak | 63.85 | 13.60 | 32 | 80585 | 595 | 29871266 |
| Injection site pain | 62.66 | 13.60 | 5 | 80612 | 30305 | 29841556 |
| Folliculitis | 62.21 | 13.60 | 62 | 80555 | 3578 | 29868283 |
| Confusional state | 61.96 | 13.60 | 173 | 80444 | 134661 | 29737200 |
| Dizziness | 61.86 | 13.60 | 292 | 80325 | 194617 | 29677244 |
| Influenza | 61.57 | 13.60 | 20 | 80597 | 43378 | 29828483 |
| Cholangitis | 60.56 | 13.60 | 89 | 80528 | 7713 | 29864148 |
| Coronary artery disease | 60.53 | 13.60 | 29 | 80588 | 49683 | 29822178 |
| Dry skin | 60.22 | 13.60 | 164 | 80453 | 22290 | 29849571 |
| Myocardial infarction | 59.35 | 13.60 | 159 | 80458 | 125466 | 29746395 |
| Cholinergic syndrome | 58.34 | 13.60 | 28 | 80589 | 472 | 29871389 |
| Joint swelling | 57.75 | 13.60 | 27 | 80590 | 46919 | 29824942 |
| Rash pustular | 57.45 | 13.60 | 69 | 80548 | 4914 | 29866947 |
| Tumour necrosis | 57.11 | 13.60 | 36 | 80581 | 1057 | 29870804 |
| Feeling abnormal | 56.61 | 13.60 | 42 | 80575 | 56714 | 29815147 |
| Muscle spasms | 56.09 | 13.60 | 55 | 80562 | 64783 | 29807078 |
| Intestinal perforation | 56.02 | 13.60 | 90 | 80527 | 8429 | 29863432 |
| Rectal cancer metastatic | 56.00 | 13.60 | 22 | 80595 | 221 | 29871640 |
| Disseminated intravascular coagulation | 55.58 | 13.60 | 158 | 80459 | 22013 | 29849848 |
| Agitation | 55.25 | 13.60 | 39 | 80578 | 54034 | 29817827 |
| Metastases to peritoneum | 54.44 | 13.60 | 40 | 80577 | 1517 | 29870344 |
| Adenocarcinoma of colon | 54.29 | 13.60 | 55 | 80562 | 3237 | 29868624 |
| Intravascular haemolysis | 54.12 | 13.60 | 25 | 80592 | 385 | 29871476 |
| Epistaxis | 53.69 | 13.60 | 283 | 80334 | 52698 | 29819163 |
| Incorrect drug administration rate | 53.39 | 13.60 | 35 | 80582 | 1101 | 29870760 |
| Venous thrombosis | 53.28 | 13.60 | 54 | 80563 | 3180 | 29868681 |
| Asthenia | 53.09 | 13.60 | 863 | 79754 | 220427 | 29651434 |
| Tumour perforation | 52.76 | 13.60 | 22 | 80595 | 261 | 29871600 |
| Tremor | 52.33 | 13.60 | 76 | 80541 | 75287 | 29796574 |
| Bradycardia | 50.68 | 13.60 | 61 | 80556 | 65465 | 29806396 |
| Anastomotic fistula | 49.59 | 13.60 | 14 | 80603 | 42 | 29871819 |
| Carbohydrate antigen 19-9 increased | 49.44 | 13.60 | 19 | 80598 | 179 | 29871682 |
| Anal haemorrhage | 48.85 | 13.60 | 39 | 80578 | 1676 | 29870185 |
| Contusion | 48.84 | 13.60 | 12 | 80605 | 31268 | 29840593 |
| Sinusitis | 47.95 | 13.60 | 15 | 80602 | 33330 | 29838531 |
| Malignant ascites | 47.90 | 13.60 | 23 | 80594 | 388 | 29871473 |
| Oesophagitis | 47.89 | 13.60 | 98 | 80519 | 11073 | 29860788 |
| Conjunctivitis | 47.87 | 13.60 | 81 | 80536 | 7919 | 29863942 |
| Therapeutic product effect decreased | 47.71 | 13.60 | 10 | 80607 | 29066 | 29842795 |
| Disturbance in attention | 47.62 | 13.60 | 3 | 80614 | 22126 | 29849735 |
| Fluid retention | 46.80 | 13.60 | 6 | 80611 | 24992 | 29846869 |
| Injury | 46.60 | 13.60 | 3 | 80614 | 21728 | 29850133 |
| Rectal perforation | 46.31 | 13.60 | 22 | 80595 | 362 | 29871499 |
| Unevaluable event | 46.24 | 13.60 | 14 | 80603 | 31771 | 29840090 |
| Subclavian vein thrombosis | 46.02 | 13.60 | 29 | 80588 | 851 | 29871010 |
| Incorrect dose administered | 46.02 | 13.60 | 14 | 80603 | 31672 | 29840189 |
| Vena cava thrombosis | 45.87 | 13.60 | 31 | 80586 | 1027 | 29870834 |
| Foetal exposure during pregnancy | 45.66 | 13.60 | 21 | 80596 | 36850 | 29835011 |
| Mucosal toxicity | 45.54 | 13.60 | 18 | 80599 | 184 | 29871677 |
| Fistula | 45.02 | 13.60 | 62 | 80555 | 5060 | 29866801 |
| Cardiac disorder | 44.54 | 13.60 | 26 | 80591 | 39867 | 29831994 |
| Dysphonia | 44.21 | 13.60 | 132 | 80485 | 18900 | 29852961 |
| Electrocardiogram QT prolonged | 43.47 | 13.60 | 21 | 80596 | 35814 | 29836047 |
| Memory impairment | 43.28 | 13.60 | 23 | 80594 | 37151 | 29834710 |
| Pulmonary artery thrombosis | 42.89 | 13.60 | 25 | 80592 | 635 | 29871226 |
| Treatment noncompliance | 42.87 | 13.60 | 8 | 80609 | 25245 | 29846616 |
| Stress | 42.78 | 13.60 | 3 | 80614 | 20232 | 29851629 |
| Administration site extravasation | 42.72 | 13.60 | 21 | 80596 | 374 | 29871487 |
| Wheezing | 42.59 | 13.60 | 15 | 80602 | 30923 | 29840938 |
| Hypoglycaemia | 42.10 | 13.60 | 45 | 80572 | 50936 | 29820925 |
| Large intestinal obstruction | 41.97 | 13.60 | 33 | 80584 | 1387 | 29870474 |
| Cytomegalovirus oesophagitis | 41.90 | 13.60 | 18 | 80599 | 231 | 29871630 |
| Transdifferentiation of neoplasm | 41.01 | 13.60 | 13 | 80604 | 64 | 29871797 |
| Product use issue | 41.00 | 13.60 | 38 | 80579 | 45978 | 29825883 |
| Bacterial translocation | 40.96 | 13.60 | 18 | 80599 | 245 | 29871616 |
| Rectal cancer | 40.81 | 13.60 | 39 | 80578 | 2137 | 29869724 |
| Acral peeling skin syndrome | 40.68 | 13.60 | 12 | 80605 | 44 | 29871817 |
| Proteus infection | 40.37 | 13.60 | 25 | 80592 | 711 | 29871150 |
| Drug hypersensitivity | 40.24 | 13.60 | 77 | 80540 | 68442 | 29803419 |
| Nicotinic acid deficiency | 40.05 | 13.60 | 13 | 80604 | 70 | 29871791 |
| Irritability | 39.79 | 13.60 | 7 | 80610 | 23043 | 29848818 |
| Myelosuppression | 39.72 | 13.60 | 71 | 80546 | 7251 | 29864610 |
| Abnormal behaviour | 39.68 | 13.60 | 10 | 80607 | 25613 | 29846248 |
| Tumour haemorrhage | 39.45 | 13.60 | 41 | 80576 | 2487 | 29869374 |
| Aortic thrombosis | 39.44 | 13.60 | 24 | 80593 | 661 | 29871200 |
| Colon cancer recurrent | 39.32 | 13.60 | 14 | 80603 | 104 | 29871757 |
| Acute coronary syndrome | 39.29 | 13.60 | 102 | 80515 | 13471 | 29858390 |
| Nasopharyngitis | 39.25 | 13.60 | 61 | 80556 | 58788 | 29813073 |
| Cytomegalovirus infection | 39.14 | 13.60 | 8 | 80609 | 23666 | 29848195 |
| Liver abscess | 38.97 | 13.60 | 46 | 80571 | 3216 | 29868645 |
| Intestinal ischaemia | 38.86 | 13.60 | 68 | 80549 | 6829 | 29865032 |
| Skin fissures | 38.63 | 13.60 | 47 | 80570 | 3392 | 29868469 |
| Odynophagia | 38.59 | 13.60 | 54 | 80563 | 4473 | 29867388 |
| Enterovesical fistula | 38.37 | 13.60 | 23 | 80594 | 616 | 29871245 |
| Pelvic fluid collection | 38.32 | 13.60 | 14 | 80603 | 113 | 29871748 |
| Musculoskeletal stiffness | 37.82 | 13.60 | 25 | 80592 | 35856 | 29836005 |
| Therapy partial responder | 37.55 | 13.60 | 48 | 80569 | 3643 | 29868218 |
| International normalised ratio increased | 37.38 | 13.60 | 44 | 80573 | 47695 | 29824166 |
| Hyperkalaemia | 37.19 | 13.60 | 76 | 80541 | 65934 | 29805927 |
| Hyperbilirubinaemia | 37.01 | 13.60 | 115 | 80502 | 16827 | 29855034 |
| Gastric perforation | 36.59 | 13.60 | 36 | 80581 | 2045 | 29869816 |
| Off label use | 36.50 | 13.60 | 903 | 79714 | 248387 | 29623474 |
| Skin disorder | 36.49 | 13.60 | 90 | 80527 | 11518 | 29860343 |
| Perforation | 36.42 | 13.60 | 15 | 80602 | 172 | 29871689 |
| Oesophagobronchial fistula | 36.14 | 13.60 | 14 | 80603 | 135 | 29871726 |
| Venoocclusive liver disease | 35.72 | 13.60 | 64 | 80553 | 6549 | 29865312 |
| Respiratory arrest | 35.71 | 13.60 | 17 | 80600 | 29241 | 29842620 |
| Diabetes mellitus | 35.64 | 13.60 | 36 | 80581 | 41829 | 29830032 |
| Duodenal perforation | 35.63 | 13.60 | 28 | 80589 | 1176 | 29870685 |
| Stress cardiomyopathy | 35.37 | 13.60 | 31 | 80586 | 1518 | 29870343 |
| Cellulitis | 34.66 | 13.60 | 45 | 80572 | 46739 | 29825122 |
| Tumour marker increased | 34.63 | 13.60 | 20 | 80597 | 499 | 29871362 |
| Subacute cutaneous lupus erythematosus | 34.57 | 13.60 | 22 | 80595 | 657 | 29871204 |
| Induration | 34.55 | 13.60 | 24 | 80593 | 832 | 29871029 |
| Hypertransaminasaemia | 34.10 | 13.60 | 47 | 80570 | 3838 | 29868023 |
| Abdominal discomfort | 34.06 | 13.60 | 49 | 80568 | 48742 | 29823119 |
| Gastrointestinal necrosis | 33.82 | 13.60 | 43 | 80574 | 3246 | 29868615 |
| Hypersensitivity | 33.72 | 13.60 | 255 | 80362 | 53773 | 29818088 |
| Oesophageal perforation | 33.63 | 13.60 | 19 | 80598 | 454 | 29871407 |
| Arthritis | 33.30 | 13.60 | 12 | 80605 | 24389 | 29847472 |
| White blood cell count decreased | 33.28 | 13.60 | 359 | 80258 | 83588 | 29788273 |
| Renal disorder | 33.21 | 13.60 | 11 | 80606 | 23573 | 29848288 |
| Laryngospasm | 32.94 | 13.60 | 28 | 80589 | 1315 | 29870546 |
| Pain | 32.70 | 13.60 | 302 | 80315 | 172339 | 29699522 |
| Blood creatine phosphokinase increased | 32.66 | 13.60 | 42 | 80575 | 43806 | 29828055 |
| Influenza like illness | 32.62 | 13.60 | 14 | 80603 | 25591 | 29846270 |
| Hallucination, visual | 32.37 | 13.60 | 3 | 80614 | 16110 | 29855751 |
| Left ventricular dysfunction | 32.36 | 13.60 | 72 | 80545 | 8619 | 29863242 |
| Psychotic disorder | 32.17 | 13.60 | 9 | 80608 | 21506 | 29850355 |
| Gait disturbance | 32.09 | 13.60 | 99 | 80518 | 74678 | 29797183 |
| Chronic kidney disease | 31.68 | 13.60 | 33 | 80584 | 37805 | 29834056 |
| Acne | 31.63 | 13.60 | 75 | 80542 | 9361 | 29862500 |
| Neutropenic sepsis | 31.26 | 13.60 | 84 | 80533 | 11325 | 29860536 |
| Colitis microscopic | 30.95 | 13.60 | 30 | 80587 | 1673 | 29870188 |
| Oesophageal stenosis | 30.88 | 13.60 | 29 | 80588 | 1554 | 29870307 |
| Enterocutaneous fistula | 30.67 | 13.60 | 21 | 80596 | 711 | 29871150 |
| Stoma site haemorrhage | 30.65 | 13.60 | 23 | 80594 | 901 | 29870960 |
| Portal vein thrombosis | 30.55 | 13.60 | 42 | 80575 | 3422 | 29868439 |
| Tumour lysis syndrome | 30.53 | 13.60 | 90 | 80527 | 12795 | 29859066 |
| Vasospasm | 30.05 | 13.60 | 16 | 80601 | 339 | 29871522 |
| Hypertension | 30.03 | 13.60 | 476 | 80141 | 120878 | 29750983 |
| Hypophagia | 29.95 | 13.60 | 129 | 80488 | 22107 | 29849754 |
| Lung neoplasm malignant | 29.91 | 13.60 | 3 | 80614 | 15129 | 29856732 |
| Peritoneal neoplasm | 29.70 | 13.60 | 9 | 80608 | 37 | 29871824 |
| Bronchitis | 29.63 | 13.60 | 37 | 80580 | 39088 | 29832773 |
| Recall phenomenon | 29.48 | 13.60 | 19 | 80598 | 580 | 29871281 |
| Liver function test abnormal | 29.46 | 13.60 | 24 | 80593 | 30926 | 29840935 |
| Nephrolithiasis | 29.39 | 13.60 | 15 | 80602 | 24795 | 29847066 |
| Oral pain | 29.32 | 13.60 | 73 | 80544 | 9396 | 29862465 |
| Balance disorder | 29.25 | 13.60 | 33 | 80584 | 36460 | 29835401 |
| Hepatic lesion | 29.14 | 13.60 | 39 | 80578 | 3097 | 29868764 |
| Anal fissure | 29.04 | 13.60 | 34 | 80583 | 2357 | 29869504 |
| Hypovolaemic shock | 29.02 | 13.60 | 58 | 80559 | 6442 | 29865419 |
| Proctitis | 28.71 | 13.60 | 32 | 80585 | 2102 | 29869759 |
| Dysphagia | 28.59 | 13.60 | 255 | 80362 | 56443 | 29815418 |
| Subdural haematoma | 28.25 | 13.60 | 8 | 80609 | 18964 | 29852897 |
| Cerebrovascular accident | 28.25 | 13.60 | 122 | 80495 | 83355 | 29788506 |
| Acute abdomen | 28.13 | 13.60 | 29 | 80588 | 1742 | 29870119 |
| Mouth ulceration | 27.95 | 13.60 | 77 | 80540 | 10532 | 29861329 |
| Dyspnoea | 27.87 | 13.60 | 684 | 79933 | 332611 | 29539250 |
| Nodular regenerative hyperplasia | 27.79 | 13.60 | 20 | 80597 | 734 | 29871127 |
| Hypoalbuminaemia | 27.75 | 13.60 | 79 | 80538 | 11013 | 29860848 |
| Catheter site thrombosis | 27.63 | 13.60 | 8 | 80609 | 27 | 29871834 |
| Head injury | 27.62 | 13.60 | 6 | 80611 | 17014 | 29854847 |
| Aphthous ulcer | 27.57 | 13.60 | 44 | 80573 | 4097 | 29867764 |
| Colitis | 27.44 | 13.60 | 159 | 80458 | 30661 | 29841200 |
| Jugular vein thrombosis | 27.43 | 13.60 | 26 | 80591 | 1410 | 29870451 |
| Proctalgia | 27.14 | 13.60 | 45 | 80572 | 4327 | 29867534 |
| Drug level increased | 26.85 | 13.60 | 8 | 80609 | 18346 | 29853515 |
| Nail toxicity | 26.77 | 13.60 | 8 | 80609 | 31 | 29871830 |
| Emotional distress | 26.75 | 13.60 | 5 | 80612 | 15760 | 29856101 |
| Pneumonitis | 26.67 | 13.60 | 145 | 80472 | 27309 | 29844552 |
| Urticaria | 26.60 | 13.60 | 68 | 80549 | 54538 | 29817323 |
| Device related thrombosis | 26.53 | 13.60 | 20 | 80597 | 789 | 29871072 |
| PIK3CA-activated mutation | 26.42 | 13.60 | 10 | 80607 | 90 | 29871771 |
| Anaemia of malignant disease | 26.35 | 13.60 | 16 | 80601 | 439 | 29871422 |
| Cough | 26.34 | 13.60 | 214 | 80403 | 125428 | 29746433 |
| Pancreatitis | 26.11 | 13.60 | 36 | 80581 | 36454 | 29835407 |
| Biliary tract infection | 26.09 | 13.60 | 16 | 80601 | 447 | 29871414 |
| Anaemia | 25.95 | 13.60 | 738 | 79879 | 207254 | 29664607 |
| Seizure | 25.90 | 13.60 | 157 | 80460 | 98318 | 29773543 |
| Dihydropyrimidine dehydrogenase deficiency | 25.86 | 13.60 | 9 | 80608 | 62 | 29871799 |
| Hepatitis B | 25.71 | 13.60 | 53 | 80564 | 6019 | 29865842 |
| Nephrotic syndrome | 25.59 | 13.60 | 57 | 80560 | 6828 | 29865033 |
| Carbohydrate antigen 15-3 increased | 25.38 | 13.60 | 9 | 80608 | 66 | 29871795 |
| Sleep apnoea syndrome | 25.30 | 13.60 | 7 | 80610 | 16850 | 29855011 |
| Protein urine | 25.29 | 13.60 | 18 | 80599 | 649 | 29871212 |
| Toxic erythema of chemotherapy | 24.97 | 13.60 | 8 | 80609 | 41 | 29871820 |
| Gastrointestinal ischaemia | 24.91 | 13.60 | 12 | 80605 | 204 | 29871657 |
| Pneumonitis chemical | 24.88 | 13.60 | 11 | 80606 | 152 | 29871709 |
| Nail disorder | 24.67 | 13.60 | 27 | 80590 | 1738 | 29870123 |
| Anal erythema | 24.60 | 13.60 | 9 | 80608 | 73 | 29871788 |
| Adenocarcinoma | 24.57 | 13.60 | 27 | 80590 | 1746 | 29870115 |
| Adverse drug reaction | 24.56 | 13.60 | 16 | 80601 | 23129 | 29848732 |
| Pneumoperitoneum | 24.52 | 13.60 | 26 | 80591 | 1614 | 29870247 |
| Splenomegaly | 24.52 | 13.60 | 86 | 80531 | 13394 | 29858467 |
| Enterocolitis | 24.45 | 13.60 | 55 | 80562 | 6632 | 29865229 |
| Injection site erythema | 24.32 | 13.60 | 4 | 80613 | 13830 | 29858031 |
| Neutropenic colitis | 24.28 | 13.60 | 30 | 80587 | 2200 | 29869661 |
| Rectal adenocarcinoma | 24.22 | 13.60 | 19 | 80598 | 796 | 29871065 |
| Sedation | 24.20 | 13.60 | 7 | 80610 | 16366 | 29855495 |
| Eosinophilia | 23.95 | 13.60 | 15 | 80602 | 22145 | 29849716 |
| Soft tissue disorder | 23.76 | 13.60 | 17 | 80600 | 618 | 29871243 |
| Prothrombin level decreased | 23.73 | 13.60 | 22 | 80595 | 1160 | 29870701 |
| Conjunctival filtering bleb leak | 23.66 | 13.60 | 6 | 80611 | 10 | 29871851 |
| Deep vein thrombosis | 23.63 | 13.60 | 258 | 80359 | 60243 | 29811618 |
| Haematoma | 23.52 | 13.60 | 18 | 80599 | 23935 | 29847926 |
| Perforation bile duct | 23.52 | 13.60 | 8 | 80609 | 51 | 29871810 |
| Koebner phenomenon | 23.52 | 13.60 | 8 | 80609 | 51 | 29871810 |
| Fluid overload | 23.44 | 13.60 | 11 | 80606 | 19081 | 29852780 |
| Abdominal pain lower | 23.32 | 13.60 | 64 | 80553 | 8734 | 29863127 |
| Pulmonary fibrosis | 22.81 | 13.60 | 94 | 80523 | 15796 | 29856065 |
| Embolism | 22.73 | 13.60 | 55 | 80562 | 6954 | 29864907 |
| Cachexia | 22.65 | 13.60 | 53 | 80564 | 6558 | 29865303 |
| Perineal disorder | 22.52 | 13.60 | 8 | 80609 | 59 | 29871802 |
| Retroperitoneal abscess | 22.47 | 13.60 | 11 | 80606 | 194 | 29871667 |
| Xerosis | 22.43 | 13.60 | 15 | 80602 | 488 | 29871373 |
| Venous thrombosis limb | 22.37 | 13.60 | 26 | 80591 | 1788 | 29870073 |
| Drug intolerance | 22.37 | 13.60 | 56 | 80561 | 45235 | 29826626 |
| Necrotising oesophagitis | 22.24 | 13.60 | 14 | 80603 | 410 | 29871451 |
| Pachymeningitis | 22.11 | 13.60 | 9 | 80608 | 100 | 29871761 |
| Blood cholesterol increased | 22.06 | 13.60 | 9 | 80608 | 16961 | 29854900 |
| Pseudocirrhosis | 22.05 | 13.60 | 6 | 80611 | 15 | 29871846 |
| Wrong technique in product usage process | 22.02 | 13.60 | 31 | 80586 | 31124 | 29840737 |
| Abdominal abscess | 21.94 | 13.60 | 39 | 80578 | 3965 | 29867896 |
| Erythema | 21.94 | 13.60 | 311 | 80306 | 77140 | 29794721 |
| Metastasis | 21.90 | 13.60 | 35 | 80582 | 3263 | 29868598 |
| Diabetes mellitus inadequate control | 21.75 | 13.60 | 4 | 80613 | 12758 | 29859103 |
| Superior vena cava syndrome | 21.74 | 13.60 | 14 | 80603 | 427 | 29871434 |
| Cell-mediated cytotoxicity | 21.67 | 13.60 | 7 | 80610 | 37 | 29871824 |
| Colitis ulcerative | 21.65 | 13.60 | 6 | 80611 | 14428 | 29857433 |
| Rectosigmoid cancer | 21.65 | 13.60 | 10 | 80607 | 154 | 29871707 |
| Perioral dermatitis | 21.64 | 13.60 | 9 | 80608 | 106 | 29871755 |
| Blood pressure fluctuation | 21.62 | 13.60 | 10 | 80607 | 17493 | 29854368 |
| Balanoposthitis | 21.55 | 13.60 | 20 | 80597 | 1056 | 29870805 |
| Bacteraemia | 21.52 | 13.60 | 91 | 80526 | 15469 | 29856392 |
| Blood pressure increased | 21.46 | 13.60 | 110 | 80507 | 71818 | 29800043 |
| Hepatectomy | 21.43 | 13.60 | 8 | 80609 | 69 | 29871792 |
| Mobility decreased | 21.40 | 13.60 | 23 | 80594 | 25976 | 29845885 |
| Condition aggravated | 21.26 | 13.60 | 253 | 80364 | 137613 | 29734248 |
| Interventricular septum rupture | 21.25 | 13.60 | 6 | 80611 | 18 | 29871843 |
| Pulmonary oedema | 21.23 | 13.60 | 55 | 80562 | 43920 | 29827941 |
| Gout | 21.22 | 13.60 | 10 | 80607 | 17305 | 29854556 |
| Prostate cancer | 21.08 | 13.60 | 20 | 80597 | 23937 | 29847924 |
| Peritoneal adhesions | 21.08 | 13.60 | 7 | 80610 | 41 | 29871820 |
| Delirium | 21.04 | 13.60 | 49 | 80568 | 40582 | 29831279 |
| Ectropion | 21.04 | 13.60 | 8 | 80609 | 73 | 29871788 |
| Toxic epidermal necrolysis | 21.02 | 13.60 | 11 | 80606 | 17929 | 29853932 |
| Herpes zoster | 20.96 | 13.60 | 30 | 80587 | 29913 | 29841948 |
| Muscular weakness | 20.93 | 13.60 | 94 | 80523 | 63551 | 29808310 |
| Hepatitis C | 20.74 | 13.60 | 5 | 80612 | 13200 | 29858661 |
| Cataract | 20.69 | 13.60 | 17 | 80600 | 21818 | 29850043 |
| Anorectal discomfort | 20.68 | 13.60 | 25 | 80592 | 1792 | 29870069 |
| Hyperlipidaemia | 20.45 | 13.60 | 6 | 80611 | 13901 | 29857960 |
| Blood glucose decreased | 20.39 | 13.60 | 5 | 80612 | 13048 | 29858813 |
| Sepsis | 20.38 | 13.60 | 527 | 80090 | 145868 | 29725993 |
| Vestibular neuronitis | 20.31 | 13.60 | 8 | 80609 | 81 | 29871780 |
| Stevens-Johnson syndrome | 20.23 | 13.60 | 11 | 80606 | 17545 | 29854316 |
| Wound dehiscence | 20.22 | 13.60 | 34 | 80583 | 3307 | 29868554 |
| Acute respiratory distress syndrome | 20.19 | 13.60 | 120 | 80497 | 23352 | 29848509 |
| Anger | 20.03 | 13.60 | 3 | 80614 | 11117 | 29860744 |
| Prinzmetal angina | 20.03 | 13.60 | 18 | 80599 | 911 | 29870950 |
| Vocal cord paralysis | 19.97 | 13.60 | 17 | 80600 | 800 | 29871061 |
| Guillain-Barre syndrome | 19.93 | 13.60 | 43 | 80574 | 5040 | 29866821 |
| Metastases to pelvis | 19.93 | 13.60 | 11 | 80606 | 251 | 29871610 |
| Hepatic atrophy | 19.90 | 13.60 | 10 | 80607 | 187 | 29871674 |
| Stoma site pain | 19.75 | 13.60 | 16 | 80601 | 702 | 29871159 |
| Vision blurred | 19.66 | 13.60 | 53 | 80564 | 41763 | 29830098 |
| Perihepatic abscess | 19.64 | 13.60 | 8 | 80609 | 89 | 29871772 |
| Pancreatic carcinoma metastatic | 19.59 | 13.60 | 33 | 80584 | 3214 | 29868647 |
| Clostridial infection | 19.47 | 13.60 | 35 | 80582 | 3590 | 29868271 |
| Lower respiratory tract infection | 19.47 | 13.60 | 26 | 80591 | 26688 | 29845173 |
| Drug ineffective for unapproved indication | 19.45 | 13.60 | 3 | 80614 | 10877 | 29860984 |
| Pelvic venous thrombosis | 19.40 | 13.60 | 14 | 80603 | 516 | 29871345 |
| Full blood count decreased | 19.38 | 13.60 | 9 | 80608 | 15708 | 29856153 |
| Bacterial colitis | 19.19 | 13.60 | 6 | 80611 | 28 | 29871833 |
| Ischiorectal hernia | 19.14 | 13.60 | 5 | 80612 | 10 | 29871851 |
| Myoclonus | 19.11 | 13.60 | 6 | 80611 | 13306 | 29858555 |
| Varices oesophageal | 19 | 13.60 | 34 | 80583 | 3475 | 29868386 |
| Accidental overdose | 18.90 | 13.60 | 13 | 80604 | 18262 | 29853599 |
| Intestinal strangulation | 18.85 | 13.60 | 6 | 80611 | 30 | 29871831 |
| Lymph node abscess | 18.82 | 13.60 | 5 | 80612 | 11 | 29871850 |
| Product quality issue | 18.57 | 13.60 | 14 | 80603 | 18760 | 29853101 |
| Erectile dysfunction | 18.55 | 13.60 | 13 | 80604 | 18089 | 29853772 |
| Colorectal cancer recurrent | 18.53 | 13.60 | 6 | 80611 | 32 | 29871829 |
| Radiation mucositis | 18.53 | 13.60 | 8 | 80609 | 104 | 29871757 |
| Peritoneal haematoma | 18.49 | 13.60 | 7 | 80610 | 63 | 29871798 |
| Peritonitis bacterial | 18.49 | 13.60 | 4 | 80613 | 11374 | 29860487 |
| Dyskinesia | 18.32 | 13.60 | 19 | 80598 | 21815 | 29850046 |
| Thrombotic thrombocytopenic purpura | 18.31 | 13.60 | 33 | 80584 | 3392 | 29868469 |
| Underdose | 18.30 | 13.60 | 5 | 80612 | 12136 | 29859725 |
| Radiation skin injury | 18.19 | 13.60 | 15 | 80602 | 675 | 29871186 |
| Contraindicated product administered | 18.16 | 13.60 | 12 | 80605 | 17219 | 29854642 |
| Colony stimulating factor therapy | 18.12 | 13.60 | 9 | 80608 | 164 | 29871697 |
| Fixed eruption | 18.11 | 13.60 | 19 | 80598 | 1165 | 29870696 |
| Oesophageal haemorrhage | 18.06 | 13.60 | 19 | 80598 | 1169 | 29870692 |
| Gastrointestinal inflammation | 18.06 | 13.60 | 30 | 80587 | 2889 | 29868972 |
| Pancreatic neuroendocrine tumour metastatic | 17.88 | 13.60 | 9 | 80608 | 169 | 29871692 |
| Hypercreatininaemia | 17.88 | 13.60 | 13 | 80604 | 485 | 29871376 |
| Treatment failure | 17.82 | 13.60 | 42 | 80575 | 34637 | 29837224 |
| Rib fracture | 17.79 | 13.60 | 6 | 80611 | 12714 | 29859147 |
| Visceral venous thrombosis | 17.71 | 13.60 | 5 | 80612 | 15 | 29871846 |
| Mental disorder | 17.70 | 13.60 | 7 | 80610 | 13442 | 29858419 |
| Acute cutaneous lupus erythematosus | 17.67 | 13.60 | 7 | 80610 | 72 | 29871789 |
| Refeeding syndrome | 17.67 | 13.60 | 6 | 80611 | 38 | 29871823 |
| Nail ridging | 17.67 | 13.60 | 6 | 80611 | 38 | 29871823 |
| K-ras gene mutation | 17.47 | 13.60 | 5 | 80612 | 16 | 29871845 |
| Portal vein embolisation | 17.45 | 13.60 | 4 | 80613 | 3 | 29871858 |
| Gastrointestinal obstruction | 17.37 | 13.60 | 15 | 80602 | 720 | 29871141 |
| Enterocolitis haemorrhagic | 17.36 | 13.60 | 17 | 80600 | 960 | 29870901 |
| Oesophageal cancer metastatic | 17.30 | 13.60 | 10 | 80607 | 250 | 29871611 |
| Performance status decreased | 17.30 | 13.60 | 35 | 80582 | 3922 | 29867939 |
| Duodenal ulcer perforation | 17.21 | 13.60 | 22 | 80595 | 1670 | 29870191 |
| Adverse event | 17.12 | 13.60 | 10 | 80607 | 15331 | 29856530 |
| Primitive neuroectodermal tumour | 17.10 | 13.60 | 7 | 80610 | 79 | 29871782 |
| Premature baby | 17.09 | 13.60 | 12 | 80605 | 16679 | 29855182 |
| Dysaesthesia pharynx | 17.04 | 13.60 | 6 | 80611 | 43 | 29871818 |
| Unresponsive to stimuli | 17.02 | 13.60 | 28 | 80589 | 26391 | 29845470 |
| Pulmonary infarction | 16.98 | 13.60 | 18 | 80599 | 1117 | 29870744 |
| Inferior vena cava dilatation | 16.97 | 13.60 | 9 | 80608 | 189 | 29871672 |
| Tubulointerstitial nephritis | 16.87 | 13.60 | 14 | 80603 | 17877 | 29853984 |
| COVID-19 | 16.84 | 13.60 | 14 | 80603 | 17864 | 29853997 |
| Tetany | 16.83 | 13.60 | 15 | 80602 | 751 | 29871110 |
| Viral infection | 16.80 | 13.60 | 10 | 80607 | 15175 | 29856686 |
| Acute motor-sensory axonal neuropathy | 16.77 | 13.60 | 8 | 80609 | 133 | 29871728 |
| Gastrointestinal anastomotic leak | 16.75 | 13.60 | 11 | 80606 | 347 | 29871514 |
| Gastrointestinal stoma complication | 16.74 | 13.60 | 19 | 80598 | 1273 | 29870588 |
| Myopathy | 16.64 | 13.60 | 4 | 80613 | 10582 | 29861279 |
| Pulmonary hypertension | 16.62 | 13.60 | 16 | 80601 | 19020 | 29852841 |
| VIth nerve disorder | 16.61 | 13.60 | 5 | 80612 | 20 | 29871841 |
| Road traffic accident | 16.54 | 13.60 | 13 | 80604 | 17058 | 29854803 |
| Osteoarthritis | 16.52 | 13.60 | 15 | 80602 | 18334 | 29853527 |
| Lymphangiosis carcinomatosa | 16.49 | 13.60 | 16 | 80601 | 893 | 29870968 |
| Anaphylactic shock | 16.46 | 13.60 | 78 | 80539 | 13915 | 29857946 |
| Renal salt-wasting syndrome | 16.45 | 13.60 | 8 | 80609 | 139 | 29871722 |
| Rectal abscess | 16.45 | 13.60 | 16 | 80601 | 896 | 29870965 |
| Hypersomnia | 16.43 | 13.60 | 5 | 80612 | 11311 | 29860550 |
| Fistula of small intestine | 16.37 | 13.60 | 11 | 80606 | 361 | 29871500 |
| B-cell small lymphocytic lymphoma | 16.30 | 13.60 | 8 | 80609 | 142 | 29871719 |
| Prostatic specific antigen increased | 16.21 | 13.60 | 6 | 80611 | 11998 | 29859863 |
| Duodenal stenosis | 16.20 | 13.60 | 9 | 80608 | 208 | 29871653 |
| Diffuse alveolar damage | 16.18 | 13.60 | 23 | 80594 | 1933 | 29869928 |
| Swelling face | 16.11 | 13.60 | 20 | 80597 | 21184 | 29850677 |
| Oesophageal squamous cell carcinoma metastatic | 16.03 | 13.60 | 4 | 80613 | 6 | 29871855 |
| Cerebral haemorrhage | 15.98 | 13.60 | 41 | 80576 | 32846 | 29839015 |
| Product prescribing error | 15.89 | 13.60 | 13 | 80604 | 16720 | 29855141 |
| Blood triglycerides increased | 15.83 | 13.60 | 9 | 80608 | 14008 | 29857853 |
| Monocytopenia | 15.81 | 13.60 | 7 | 80610 | 97 | 29871764 |
| Osteomyelitis | 15.78 | 13.60 | 10 | 80607 | 14671 | 29857190 |
| Periportal sinus dilatation | 15.71 | 13.60 | 5 | 80612 | 25 | 29871836 |
| Product use in unapproved indication | 15.67 | 13.60 | 125 | 80492 | 73568 | 29798293 |
| Hepatic artery occlusion | 15.66 | 13.60 | 6 | 80611 | 56 | 29871805 |
| Pigmentation disorder | 15.56 | 13.60 | 23 | 80594 | 2003 | 29869858 |
| Accidental exposure to product | 15.56 | 13.60 | 4 | 80613 | 10111 | 29861750 |
| Paraesthesia oral | 15.55 | 13.60 | 32 | 80585 | 3629 | 29868232 |
| Visual impairment | 15.53 | 13.60 | 37 | 80580 | 30401 | 29841460 |
| Neoplasm recurrence | 15.51 | 13.60 | 22 | 80595 | 1845 | 29870016 |
| Heart rate increased | 15.40 | 13.60 | 53 | 80564 | 38668 | 29833193 |
| Product substitution issue | 15.37 | 13.60 | 4 | 80613 | 10031 | 29861830 |
| Neurosarcoidosis | 15.35 | 13.60 | 8 | 80609 | 162 | 29871699 |
| Hepatic enzyme increased | 15.33 | 13.60 | 43 | 80574 | 33451 | 29838410 |
| Intrahepatic portal hepatic venous fistula | 15.31 | 13.60 | 4 | 80613 | 8 | 29871853 |
| Oral dysaesthesia | 15.30 | 13.60 | 6 | 80611 | 60 | 29871801 |
| Pneumoretroperitoneum | 15.30 | 13.60 | 6 | 80611 | 60 | 29871801 |
| Arthropathy | 15.28 | 13.60 | 20 | 80597 | 20707 | 29851154 |
| Injection site reaction | 15.18 | 13.60 | 5 | 80612 | 10755 | 29861106 |
| Rectal stenosis | 15.17 | 13.60 | 8 | 80609 | 166 | 29871695 |
| Product administration error | 15.17 | 13.60 | 10 | 80607 | 14367 | 29857494 |
| Heart rate irregular | 15.15 | 13.60 | 7 | 80610 | 12252 | 29859609 |
| Respiratory depression | 15.12 | 13.60 | 6 | 80611 | 11497 | 29860364 |
| Angioedema | 15.11 | 13.60 | 45 | 80572 | 34339 | 29837522 |
| Obstructive airways disorder | 15.10 | 13.60 | 3 | 80614 | 9056 | 29862805 |
| Tracheal stenosis | 15.04 | 13.60 | 8 | 80609 | 169 | 29871692 |
| Rectal ulcer | 15.04 | 13.60 | 15 | 80602 | 866 | 29870995 |
| Device related sepsis | 14.93 | 13.60 | 24 | 80593 | 2248 | 29869613 |
| Gastroenteritis radiation | 14.88 | 13.60 | 10 | 80607 | 328 | 29871533 |
| Dysgeusia | 14.87 | 13.60 | 116 | 80501 | 24685 | 29847176 |
| Laboratory test abnormal | 14.84 | 13.60 | 15 | 80602 | 17427 | 29854434 |
| Jaundice | 14.80 | 13.60 | 143 | 80474 | 32343 | 29839518 |
| No adverse event | 14.80 | 13.60 | 15 | 80602 | 17404 | 29854457 |
| Chemotherapy | 14.79 | 13.60 | 12 | 80605 | 528 | 29871333 |
| Abscess | 14.77 | 13.60 | 60 | 80557 | 10018 | 29861843 |
| Herpes simplex meningomyelitis | 14.76 | 13.60 | 3 | 80614 | 0 | 29871861 |
| Pneumomediastinum | 14.73 | 13.60 | 21 | 80596 | 1770 | 29870091 |
| Heart rate decreased | 14.73 | 13.60 | 21 | 80596 | 20973 | 29850888 |
| Tumour fistulisation | 14.70 | 13.60 | 4 | 80613 | 10 | 29871851 |
| Vascular device infection | 14.57 | 13.60 | 21 | 80596 | 1788 | 29870073 |
| Radiation interaction | 14.55 | 13.60 | 5 | 80612 | 33 | 29871828 |
| Non-cirrhotic portal hypertension | 14.53 | 13.60 | 9 | 80608 | 256 | 29871605 |
| Device infusion issue | 14.52 | 13.60 | 12 | 80605 | 542 | 29871319 |
| Swelling | 14.47 | 13.60 | 49 | 80568 | 35926 | 29835935 |
| Astringent therapy | 14.42 | 13.60 | 4 | 80613 | 11 | 29871850 |
| Cardiac ventricular thrombosis | 14.41 | 13.60 | 14 | 80603 | 783 | 29871078 |
| Evans syndrome | 14.38 | 13.60 | 9 | 80608 | 261 | 29871600 |
| Limbic encephalitis | 14.25 | 13.60 | 9 | 80608 | 265 | 29871596 |
| Stress ulcer | 14.25 | 13.60 | 6 | 80611 | 73 | 29871788 |
| Axillary vein thrombosis | 14.24 | 13.60 | 8 | 80609 | 189 | 29871672 |
| Drug-induced liver injury | 14.22 | 13.60 | 22 | 80595 | 21252 | 29850609 |
| Hernia | 14.22 | 13.60 | 3 | 80614 | 8683 | 29863178 |
| Sarcoidosis | 14.21 | 13.60 | 26 | 80591 | 2703 | 29869158 |
| Trichomegaly | 14.17 | 13.60 | 4 | 80613 | 12 | 29871849 |
| Temperature difference of extremities | 14.17 | 13.60 | 4 | 80613 | 12 | 29871849 |
| Oedema peripheral | 14.17 | 13.60 | 200 | 80417 | 105632 | 29766229 |
| Swollen tongue | 14.16 | 13.60 | 9 | 80608 | 13183 | 29858678 |
| Eye pain | 14.15 | 13.60 | 7 | 80610 | 11782 | 29860079 |
| Fatigue | 14.14 | 13.60 | 1023 | 79594 | 319650 | 29552211 |
| Intestinal mucosal hypertrophy | 14.11 | 13.60 | 6 | 80611 | 75 | 29871786 |
| Rectal haemorrhage | 14.10 | 13.60 | 150 | 80467 | 34789 | 29837072 |
| Productive cough | 14.05 | 13.60 | 38 | 80579 | 29915 | 29841946 |
| Bacteriuria | 14.05 | 13.60 | 9 | 80608 | 272 | 29871589 |
| Procedural vomiting | 14.02 | 13.60 | 7 | 80610 | 129 | 29871732 |
| Aspergillus infection | 13.97 | 13.60 | 5 | 80612 | 10209 | 29861652 |
| Hyperthermia | 13.91 | 13.60 | 59 | 80558 | 10040 | 29861821 |
| Localised infection | 13.90 | 13.60 | 10 | 80607 | 13727 | 29858134 |
| Suture rupture | 13.82 | 13.60 | 10 | 80607 | 370 | 29871491 |
| Necrotising colitis | 13.76 | 13.60 | 15 | 80602 | 961 | 29870900 |
| Anal fistula | 13.70 | 13.60 | 32 | 80585 | 3954 | 29867907 |
| Pulmonary arterial hypertension | 13.70 | 13.60 | 4 | 80613 | 9297 | 29862564 |
| Neck pain | 13.68 | 13.60 | 22 | 80595 | 20922 | 29850939 |
| Hepatic failure | 13.66 | 13.60 | 146 | 80471 | 33897 | 29837964 |
Pharmacologic Action:
| Source | Code | Description |
|---|---|---|
| ATC | L01BC02 | ANTINEOPLASTIC AND IMMUNOMODULATING AGENTS ANTINEOPLASTIC AGENTS ANTIMETABOLITES Pyrimidine analogues |
| ATC | L01BC52 | ANTINEOPLASTIC AND IMMUNOMODULATING AGENTS ANTINEOPLASTIC AGENTS ANTIMETABOLITES Pyrimidine analogues |
| FDA MoA | N0000000233 | Nucleic Acid Synthesis Inhibitors |
| FDA EPC | N0000175595 | Nucleoside Metabolic Inhibitor |
| MeSH PA | D000963 | Antimetabolites |
| MeSH PA | D000964 | Antimetabolites, Antineoplastic |
| MeSH PA | D000970 | Antineoplastic Agents |
| MeSH PA | D007155 | Immunologic Factors |
| MeSH PA | D007166 | Immunosuppressive Agents |
| MeSH PA | D009676 | Noxae |
| CHEBI has role | CHEBI:35221 | antimetabolite |
| CHEBI has role | CHEBI:35610 | cytostatic |
| CHEBI has role | CHEBI:35703 | xenobiotic |
| CHEBI has role | CHEBI:35705 | immunosuppressant |
| CHEBI has role | CHEBI:78298 | environmental contaminants |
| CHEBI has role | CHEBI:132992 | radiosensitizers |
Drug Use (View source of the data)
| Disease | Relation | SNOMED_ID | DOID |
|---|---|---|---|
| Actinic keratosis | indication | 201101007 | DOID:8866 |
| Metastasis from malignant tumor of colon | indication | 314998002 | |
| Malignant tumor of stomach | indication | 363349007 | DOID:10534 |
| Malignant tumor of colon | indication | 363406005 | DOID:219 |
| Superficial basal cell carcinoma | indication | 403914000 | |
| Adenocarcinoma of pancreas | indication | 700423003 | DOID:4074 |
| Metastatic Breast Carcinoma | indication | ||
| Carcinoid syndrome | off-label use | 35868009 | |
| Actinic cheilitis | off-label use | 46795000 | |
| Radiation dermatitis | off-label use | 49084001 | |
| Neoplasm of glans penis | off-label use | 126898002 | |
| Carcinoma of breast | off-label use | 254838004 | DOID:3459 |
| Malignant tumor of head and/or neck | off-label use | 255056009 | |
| Malignant tumor of cervix | off-label use | 363354003 | DOID:4362 |
| Malignant tumor of esophagus | off-label use | 363402007 | |
| Malignant tumor of anus | off-label use | 363490009 | DOID:14110 |
| Malignant tumor of urinary bladder | off-label use | 399326009 | DOID:11054 |
| Leukoplakia of oral mucosa | off-label use | 414603003 | |
| Biliary Tract Malignancy | off-label use | ||
| Metastatic Malignant Tumor of Anus | off-label use | ||
| Pancreatic Neuroendocrine Tumor | off-label use | ||
| Nutritional disorder | contraindication | 2492009 | DOID:374 |
| Acute vomiting | contraindication | 23971007 | |
| Stomatitis | contraindication | 61170000 | DOID:9637 |
| Diarrhea | contraindication | 62315008 | |
| Acute infectious disease | contraindication | 63171007 | |
| Gastrointestinal hemorrhage | contraindication | 74474003 | |
| Dihydrouracil dehydrogenase (NADP^+^) deficiency | contraindication | 77365006 | DOID:14218 |
| Leukopenia | contraindication | 84828003 | DOID:615 |
| Kidney disease | contraindication | 90708001 | DOID:557 |
| Superficial ulcer of skin | contraindication | 93448009 | |
| Secondary malignant neoplasm of bone marrow | contraindication | 94217008 | |
| Bleeding | contraindication | 131148009 | |
| Angina pectoris | contraindication | 194828000 | |
| Disease of liver | contraindication | 235856003 | DOID:409 |
| Pregnancy, function | contraindication | 289908002 | |
| Thrombocytopenic disorder | contraindication | 302215000 | DOID:1588 |
| Neutropenic disorder | contraindication | 303011007 | DOID:1227 |
| Bone marrow depression | contraindication | 307762000 | |
| Pharyngitis | contraindication | 405737000 | DOID:2275 |
| Breastfeeding (mother) | contraindication | 413712001 | |
| Palmar-Plantar Erythrodysesthesia | contraindication |
Acid dissociation constants calculated using MoKa v3.0.0
| Dissociation level | Dissociation constant | Type (acidic/basic) |
|---|---|---|
| pKa1 | 8.02 | acidic |
Orange Book patent data (new drug applications)
None
Orange Book exclusivity data (new drug applications)
None
Bioactivity Summary:
| Target | Class | Pharos | UniProt | Action | Type | Activity value (-log[M]) | Mechanism action | Bioact source | MoA source |
|---|---|---|---|---|---|---|---|---|---|
| Thymidylate synthase | Enzyme | INHIBITOR | WOMBAT-PK | CHEMBL | |||||
| ATP-binding cassette sub-family C member 11 | Transporter | WOMBAT-PK | |||||||
| Multidrug resistance-associated protein 5 | Transporter | WOMBAT-PK | |||||||
| Thymidylate synthase | Enzyme | IC50 | 7.70 | CHEMBL | |||||
| Uracil phosphoribosyltransferase | Unclassified | Ki | 4.89 | CHEMBL |
External reference:
| ID | Source |
|---|---|
| 4017806 | VUID |
| N0000146166 | NUI |
| D00584 | KEGG_DRUG |
| C0016360 | UMLSCUI |
| CHEBI:46345 | CHEBI |
| URF | PDB_CHEM_ID |
| CHEMBL185 | ChEMBL_ID |
| 3385 | PUBCHEM_CID |
| DB00544 | DRUGBANK_ID |
| D005472 | MESH_DESCRIPTOR_UI |
| 4789 | IUPHAR_LIGAND_ID |
| 1421 | INN_ID |
| U3P01618RT | UNII |
| 202632 | RXNORM |
| 4694 | MMSL |
| 4745 | MMSL |
| 6969 | MMSL |
| d00235 | MMSL |
| 002646 | NDDF |
| 3127006 | SNOMEDCT_US |
| 387172005 | SNOMEDCT_US |
| 4017806 | VANDF |
Pharmaceutical products:
| Product | Category | Ingredients | NDC | Form | Quantity | Route | Marketing | Label |
|---|---|---|---|---|---|---|---|---|
| Efudex | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0187-3202 | SOLUTION | 0.50 g | TOPICAL | NDA | 19 sections |
| Efudex | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0187-3203 | SOLUTION | 1.25 g | TOPICAL | NDA | 19 sections |
| Efudex | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0187-3204 | CREAM | 2 g | TOPICAL | NDA | 19 sections |
| Carac | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0187-5200 | CREAM | 5 mg | TOPICAL | NDA | 24 sections |
| Fluorouracil | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0378-4791 | CREAM | 5 mg | TOPICAL | NDA authorized generic | 19 sections |
| Fluorouracil Cream | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0378-8078 | CREAM | 5 mg | TOPICAL | NDA authorized generic | 22 sections |
| Fluoroplex | HUMAN PRESCRIPTION DRUG LABEL | 1 | 16110-812 | CREAM | 10 mg | TOPICAL | NDA | 23 sections |
| Fluorouracil | HUMAN PRESCRIPTION DRUG LABEL | 1 | 16729-276 | INJECTION, SOLUTION | 50 mg | INTRAVENOUS | ANDA | 24 sections |
| Fluorouracil | HUMAN PRESCRIPTION DRUG LABEL | 1 | 16729-276 | INJECTION, SOLUTION | 50 mg | INTRAVENOUS | ANDA | 24 sections |
| FLUOROURACIL | HUMAN PRESCRIPTION DRUG LABEL | 1 | 21695-829 | CREAM | 50 mg | TOPICAL | ANDA | 18 sections |
| fluorouracil | HUMAN PRESCRIPTION DRUG LABEL | 1 | 25021-215 | INJECTION, SOLUTION | 50 mg | INTRAVENOUS | ANDA | 26 sections |
| TOLAK | HUMAN PRESCRIPTION DRUG LABEL | 1 | 28105-421 | CREAM | 0.04 g | TOPICAL | NDA | 26 sections |
| Fluorouracil | HUMAN PRESCRIPTION DRUG LABEL | 1 | 50090-4264 | CREAM | 50 mg | TOPICAL | ANDA | 20 sections |
| FLUOROURACIL | HUMAN PRESCRIPTION DRUG LABEL | 1 | 50742-423 | INJECTION, SOLUTION | 50 mg | INTRAVENOUS | ANDA | 23 sections |
| FLUOROURACIL | HUMAN PRESCRIPTION DRUG LABEL | 1 | 50742-481 | INJECTION, SOLUTION | 50 mg | INTRAVENOUS | ANDA | 23 sections |
| FLUOROURACIL | HUMAN PRESCRIPTION DRUG LABEL | 1 | 50742-482 | INJECTION, SOLUTION | 2.50 g | INTRAVENOUS | ANDA | 24 sections |
| FLUOROURACIL | HUMAN PRESCRIPTION DRUG LABEL | 1 | 50742-483 | INJECTION, SOLUTION | 5 g | INTRAVENOUS | ANDA | 24 sections |
| Fluorouracil | HUMAN PRESCRIPTION DRUG LABEL | 1 | 51672-4062 | SOLUTION | 20 mg | TOPICAL | ANDA | 21 sections |
| Fluorouracil | HUMAN PRESCRIPTION DRUG LABEL | 1 | 51672-4063 | SOLUTION | 50 mg | TOPICAL | ANDA | 21 sections |
| Fluorouracil | HUMAN PRESCRIPTION DRUG LABEL | 1 | 51672-4118 | CREAM | 50 mg | TOPICAL | ANDA | 21 sections |
| FLUOROURACIL | HUMAN PRESCRIPTION DRUG LABEL | 1 | 51862-362 | CREAM | 50 mg | TOPICAL | ANDA | 21 sections |
| Fluorouracil | HUMAN PRESCRIPTION DRUG LABEL | 1 | 52549-4118 | CREAM | 50 mg | TOPICAL | ANDA | 21 sections |
| FLUOROURACIL | Human Prescription Drug Label | 1 | 54868-6293 | CREAM | 50 mg | TOPICAL | ANDA | 18 sections |
| Fluorouracil | Human Prescription Drug Label | 1 | 63323-117 | INJECTION, SOLUTION | 50 mg | INTRAVENOUS | ANDA | 25 sections |
| Fluorouracil | Human Prescription Drug Label | 1 | 63323-117 | INJECTION, SOLUTION | 50 mg | INTRAVENOUS | ANDA | 25 sections |
| Fluorouracil | Human Prescription Drug Label | 1 | 63323-117 | INJECTION, SOLUTION | 50 mg | INTRAVENOUS | ANDA | 25 sections |
| Fluorouracil | Human Prescription Drug Label | 1 | 63323-117 | INJECTION, SOLUTION | 50 mg | INTRAVENOUS | ANDA | 25 sections |
| Fluorouracil | Human Prescription Drug Label | 1 | 63323-117 | INJECTION, SOLUTION | 50 mg | INTRAVENOUS | ANDA | 25 sections |
| Fluorouracil | Human Prescription Drug Label | 1 | 63323-117 | INJECTION, SOLUTION | 50 mg | INTRAVENOUS | ANDA | 25 sections |
| FLUOROURACIL | Human Prescription Drug Label | 1 | 66530-249 | CREAM | 50 mg | TOPICAL | ANDA | 18 sections |