Stem definition | Drug id | CAS RN |
---|---|---|
uracil type antineoplastics | 26 | 51-21-8 |
None
Property | Value | Reference |
---|---|---|
BDDCS (Biopharmaceutical Drug Disposition Classification System) | 1 | Benet LZ, Broccatelli F, Oprea TI |
S (Water solubility) | 12.20 mg/mL | Benet LZ, Broccatelli F, Oprea TI |
EoM (Fraction excreted unchanged in urine) | 5 % | Benet LZ, Broccatelli F, Oprea TI |
MRTD (Maximum Recommended Therapeutic Daily Dose) | 92.25 ยตM/kg/day | Contrera JF, Matthews EJ, Kruhlak NL, Benz RD |
BA (Bioavailability) | 28 % | Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H |
Vd (Volume of distribution) | 0.23 L/kg | Lombardo F, Berellini G, Obach RS |
CL (Clearance) | 26 mL/min/kg | Lombardo F, Berellini G, Obach RS |
fu (Fraction unbound in plasma) | 0.64 % | Lombardo F, Berellini G, Obach RS |
t_half (Half-life) | 0.12 hours | Lombardo F, Berellini G, Obach RS |
Date | Agency | Company | Orphan |
---|---|---|---|
April 25, 1962 | FDA | SPECTRUM PHARMS | |
Sept. 21, 2018 | PMDA | Kyowa Hakko Kirin Co., Ltd. |
MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
---|---|---|---|---|---|---|
Neutropenia | 1805.39 | 13.43 | 1584 | 72045 | 146381 | 50385114 |
Febrile neutropenia | 974.83 | 13.43 | 936 | 72693 | 96731 | 50434764 |
Mucosal inflammation | 914.68 | 13.43 | 624 | 73005 | 39518 | 50491977 |
Neuropathy peripheral | 775.96 | 13.43 | 824 | 72805 | 95933 | 50435562 |
Diarrhoea | 701.99 | 13.43 | 2155 | 71474 | 586321 | 49945174 |
Thrombocytopenia | 566.77 | 13.43 | 807 | 72822 | 126866 | 50404629 |
Disease progression | 562.74 | 13.43 | 695 | 72934 | 95171 | 50436324 |
Palmar-plantar erythrodysaesthesia syndrome | 551.24 | 13.43 | 351 | 73278 | 19747 | 50511748 |
Leukopenia | 509.10 | 13.43 | 557 | 73072 | 66971 | 50464524 |
Neurotoxicity | 461.29 | 13.43 | 280 | 73349 | 14460 | 50517035 |
Dermatitis acneiform | 451.55 | 13.43 | 183 | 73446 | 3874 | 50527621 |
Malignant neoplasm progression | 424.05 | 13.43 | 509 | 73120 | 67615 | 50463880 |
Skin toxicity | 416.69 | 13.43 | 171 | 73458 | 3742 | 50527753 |
Metastases to liver | 375.40 | 13.43 | 277 | 73352 | 19827 | 50511668 |
Drug ineffective | 367.40 | 13.43 | 393 | 73236 | 818940 | 49712555 |
Vomiting | 344.75 | 13.43 | 1452 | 72177 | 459306 | 50072189 |
Bone marrow failure | 335.66 | 13.43 | 296 | 73333 | 27328 | 50504167 |
Stomatitis | 292.67 | 13.43 | 527 | 73102 | 100817 | 50430678 |
Metastases to lung | 273.93 | 13.43 | 181 | 73448 | 10839 | 50520656 |
Acute myeloid leukaemia | 259.80 | 13.43 | 198 | 73431 | 14876 | 50516619 |
Joint swelling | 234.46 | 13.43 | 38 | 73591 | 245248 | 50286247 |
Neutrophil count decreased | 233.94 | 13.43 | 311 | 73318 | 45715 | 50485780 |
Metastases to bone | 218.91 | 13.43 | 193 | 73436 | 17802 | 50513693 |
Polyneuropathy | 214.92 | 13.43 | 162 | 73467 | 11969 | 50519526 |
Nausea | 214.34 | 13.43 | 1751 | 71878 | 703647 | 49827848 |
Neoplasm progression | 213.41 | 13.43 | 237 | 73392 | 28920 | 50502575 |
Arthralgia | 208.68 | 13.43 | 199 | 73430 | 438503 | 50092992 |
Gastrointestinal toxicity | 208.58 | 13.43 | 112 | 73517 | 4565 | 50526930 |
Product dose omission issue | 204.06 | 13.43 | 17 | 73612 | 183821 | 50347674 |
Metastasis | 201.38 | 13.43 | 107 | 73522 | 4268 | 50527227 |
Posterior reversible encephalopathy syndrome | 199.60 | 13.43 | 169 | 73460 | 14759 | 50516736 |
Haematotoxicity | 199.44 | 13.43 | 131 | 73498 | 7764 | 50523731 |
Gastrointestinal perforation | 197.17 | 13.43 | 94 | 73535 | 2967 | 50528528 |
Peripheral sensory neuropathy | 195.42 | 13.43 | 121 | 73508 | 6470 | 50525025 |
Ejection fraction decreased | 187.05 | 13.43 | 179 | 73450 | 18341 | 50513154 |
Second primary malignancy | 185.14 | 13.43 | 119 | 73510 | 6795 | 50524700 |
Abdominal discomfort | 184.69 | 13.43 | 54 | 73575 | 231587 | 50299908 |
Systemic lupus erythematosus | 177.69 | 13.43 | 6 | 73623 | 140616 | 50390879 |
Cardiomyopathy | 177.38 | 13.43 | 161 | 73468 | 15425 | 50516070 |
Paronychia | 175.19 | 13.43 | 99 | 73530 | 4465 | 50527030 |
Arteriospasm coronary | 173.14 | 13.43 | 89 | 73540 | 3313 | 50528182 |
Interstitial lung disease | 169.53 | 13.43 | 289 | 73340 | 52887 | 50478608 |
Acute promyelocytic leukaemia | 168.03 | 13.43 | 59 | 73570 | 825 | 50530670 |
Contraindicated product administered | 164.66 | 13.43 | 14 | 73615 | 148944 | 50382551 |
Laryngospasm | 162.40 | 13.43 | 79 | 73550 | 2609 | 50528886 |
Cardiotoxicity | 161.62 | 13.43 | 110 | 73519 | 6917 | 50524578 |
Pain | 158.90 | 13.43 | 383 | 73246 | 578520 | 49952975 |
Pulmonary embolism | 158.33 | 13.43 | 412 | 73217 | 101292 | 50430203 |
Swelling | 157.96 | 13.43 | 48 | 73581 | 200824 | 50330671 |
Weight increased | 157.40 | 13.43 | 49 | 73580 | 201842 | 50329653 |
Disease recurrence | 156.97 | 13.43 | 169 | 73460 | 19912 | 50511583 |
Sinusitis | 155.10 | 13.43 | 30 | 73599 | 170528 | 50360967 |
Pyrexia | 155.09 | 13.43 | 1014 | 72615 | 379189 | 50152306 |
Hyperammonaemia | 150.99 | 13.43 | 91 | 73538 | 4633 | 50526862 |
Fall | 150.97 | 13.43 | 159 | 73470 | 334773 | 50196722 |
Dehydration | 150.63 | 13.43 | 526 | 73103 | 151923 | 50379572 |
Headache | 145.42 | 13.43 | 327 | 73302 | 506208 | 50025287 |
Decreased appetite | 144.53 | 13.43 | 627 | 73002 | 200296 | 50331199 |
Therapeutic product effect decreased | 144.48 | 13.43 | 15 | 73614 | 136035 | 50395460 |
Anaemia | 143.07 | 13.43 | 735 | 72894 | 251721 | 50279774 |
Arthropathy | 141.00 | 13.43 | 29 | 73600 | 157877 | 50373618 |
Pemphigus | 139.33 | 13.43 | 9 | 73620 | 120157 | 50411338 |
Myelosuppression | 135.27 | 13.43 | 130 | 73499 | 13387 | 50518108 |
Nasopharyngitis | 134.78 | 13.43 | 56 | 73573 | 192871 | 50338624 |
Abdominal pain | 134.69 | 13.43 | 689 | 72940 | 235539 | 50295956 |
Metastases to lymph nodes | 131.56 | 13.43 | 97 | 73532 | 6927 | 50524568 |
Wound | 128.61 | 13.43 | 6 | 73623 | 105788 | 50425707 |
Neutropenic sepsis | 124.76 | 13.43 | 127 | 73502 | 14020 | 50517475 |
Hypomagnesaemia | 124.63 | 13.43 | 161 | 73468 | 22995 | 50508500 |
General physical health deterioration | 122.58 | 13.43 | 470 | 73159 | 141964 | 50389531 |
Glossodynia | 119.51 | 13.43 | 14 | 73615 | 115555 | 50415940 |
Drug hypersensitivity | 118.92 | 13.43 | 114 | 73515 | 250896 | 50280599 |
Product use issue | 116.96 | 13.43 | 36 | 73593 | 149439 | 50382056 |
Hypokalaemia | 116.52 | 13.43 | 336 | 73293 | 87656 | 50443839 |
Injection site pain | 115.93 | 13.43 | 13 | 73616 | 111011 | 50420484 |
Large intestine perforation | 115.16 | 13.43 | 92 | 73537 | 7402 | 50524093 |
Enteritis | 114.21 | 13.43 | 89 | 73540 | 6906 | 50524589 |
Paraesthesia | 112.80 | 13.43 | 408 | 73221 | 119835 | 50411660 |
Proteinuria | 111.38 | 13.43 | 129 | 73500 | 16468 | 50515027 |
Peripheral swelling | 109.12 | 13.43 | 84 | 73545 | 205852 | 50325643 |
Pain in extremity | 100.45 | 13.43 | 151 | 73478 | 272714 | 50258781 |
Musculoskeletal stiffness | 98.62 | 13.43 | 32 | 73597 | 128449 | 50403046 |
Asthenia | 98.23 | 13.43 | 796 | 72833 | 318246 | 50213249 |
Stress cardiomyopathy | 94.72 | 13.43 | 84 | 73545 | 7803 | 50523692 |
Colorectal cancer metastatic | 92.67 | 13.43 | 33 | 73596 | 482 | 50531013 |
Neutropenic colitis | 91.61 | 13.43 | 52 | 73577 | 2365 | 50529130 |
Non-cirrhotic portal hypertension | 90.36 | 13.43 | 25 | 73604 | 147 | 50531348 |
Contusion | 87.77 | 13.43 | 27 | 73602 | 112156 | 50419339 |
Death | 87.60 | 13.43 | 788 | 72841 | 324591 | 50206904 |
Portal hypertension | 87.41 | 13.43 | 57 | 73572 | 3335 | 50528160 |
Hypertransaminasaemia | 86.56 | 13.43 | 58 | 73571 | 3553 | 50527942 |
Ileus | 85.72 | 13.43 | 101 | 73528 | 13128 | 50518367 |
Depression | 85.68 | 13.43 | 69 | 73560 | 165354 | 50366141 |
Ascites | 85.45 | 13.43 | 172 | 73457 | 35689 | 50495806 |
Maternal exposure during pregnancy | 84.83 | 13.43 | 65 | 73564 | 159713 | 50371782 |
Focal nodular hyperplasia | 82.49 | 13.43 | 30 | 73599 | 467 | 50531028 |
Intestinal perforation | 81.55 | 13.43 | 88 | 73541 | 10391 | 50521104 |
Psoriasis | 80.46 | 13.43 | 5 | 73624 | 68995 | 50462500 |
Discomfort | 79.70 | 13.43 | 29 | 73600 | 108351 | 50423144 |
Extravasation | 78.39 | 13.43 | 44 | 73585 | 1958 | 50529537 |
Cardiac failure | 75.53 | 13.43 | 263 | 73366 | 75777 | 50455718 |
Hospitalisation | 73.37 | 13.43 | 7 | 73622 | 67930 | 50463565 |
Hyperammonaemic encephalopathy | 73.06 | 13.43 | 42 | 73587 | 1957 | 50529538 |
Injection site erythema | 72.86 | 13.43 | 11 | 73618 | 74925 | 50456570 |
Left ventricular dysfunction | 72.75 | 13.43 | 83 | 73546 | 10423 | 50521072 |
Condition aggravated | 71.70 | 13.43 | 209 | 73420 | 296849 | 50234646 |
Influenza | 71.03 | 13.43 | 21 | 73608 | 89517 | 50441978 |
Drug abuse | 70.80 | 13.43 | 4 | 73625 | 59842 | 50471653 |
Drug intolerance | 70.64 | 13.43 | 132 | 73497 | 218972 | 50312523 |
Pruritus | 70.27 | 13.43 | 197 | 73432 | 283371 | 50248124 |
Arthritis | 69.41 | 13.43 | 20 | 73609 | 86701 | 50444794 |
Insomnia | 68.01 | 13.43 | 93 | 73536 | 174772 | 50356723 |
Dysarthria | 67.05 | 13.43 | 160 | 73469 | 37243 | 50494252 |
Intestinal obstruction | 67.02 | 13.43 | 130 | 73499 | 26253 | 50505242 |
Migraine | 66.79 | 13.43 | 14 | 73615 | 75266 | 50456229 |
Hepatic enzyme increased | 66.62 | 13.43 | 61 | 73568 | 137319 | 50394176 |
Enterocutaneous fistula | 66.17 | 13.43 | 33 | 73596 | 1151 | 50530344 |
Haemolytic anaemia | 65.34 | 13.43 | 74 | 73555 | 9218 | 50522277 |
Bronchitis | 63.89 | 13.43 | 36 | 73593 | 104123 | 50427372 |
Loss of personal independence in daily activities | 62.20 | 13.43 | 13 | 73616 | 70037 | 50461458 |
Peritonitis | 61.41 | 13.43 | 93 | 73536 | 15393 | 50516102 |
Mobility decreased | 61.17 | 13.43 | 20 | 73609 | 79928 | 50451567 |
Osteoarthritis | 60.37 | 13.43 | 13 | 73616 | 68593 | 50462902 |
Pancytopenia | 60.09 | 13.43 | 262 | 73367 | 83768 | 50447727 |
Helicobacter infection | 59.80 | 13.43 | 3 | 73626 | 49699 | 50481796 |
Therapy partial responder | 59.63 | 13.43 | 60 | 73569 | 6531 | 50524964 |
Suicidal ideation | 59.04 | 13.43 | 6 | 73623 | 55379 | 50476116 |
Anxiety | 58.11 | 13.43 | 106 | 73523 | 177500 | 50353995 |
Dihydropyrimidine dehydrogenase deficiency | 57.82 | 13.43 | 15 | 73614 | 66 | 50531429 |
Drug interaction | 57.74 | 13.43 | 128 | 73501 | 199493 | 50332002 |
Device related thrombosis | 57.44 | 13.43 | 31 | 73598 | 1276 | 50530219 |
Rectal perforation | 55.67 | 13.43 | 21 | 73608 | 364 | 50531131 |
Oesophageal fistula | 55.20 | 13.43 | 16 | 73613 | 114 | 50531381 |
Leukoencephalopathy | 54.04 | 13.43 | 45 | 73584 | 3838 | 50527657 |
Treatment failure | 53.70 | 13.43 | 73 | 73556 | 137564 | 50393931 |
Deep vein thrombosis | 53.51 | 13.43 | 230 | 73399 | 73074 | 50458421 |
Cholangitis | 53.46 | 13.43 | 48 | 73581 | 4531 | 50526964 |
Disseminated intravascular coagulation | 53.08 | 13.43 | 92 | 73537 | 17043 | 50514452 |
Pericarditis | 53.05 | 13.43 | 24 | 73605 | 78665 | 50452830 |
Pneumonia | 53.02 | 13.43 | 328 | 73301 | 378073 | 50153422 |
Dizziness | 52.91 | 13.43 | 292 | 73337 | 346077 | 50185418 |
Lower respiratory tract infection | 52.74 | 13.43 | 37 | 73592 | 95164 | 50436331 |
White blood cell count decreased | 52.71 | 13.43 | 320 | 73309 | 116402 | 50415093 |
Intentional product misuse | 52.69 | 13.43 | 4 | 73625 | 46730 | 50484765 |
Chronic obstructive pulmonary disease | 51.59 | 13.43 | 8 | 73621 | 53427 | 50478068 |
Congestive cardiomyopathy | 51.33 | 13.43 | 51 | 73578 | 5467 | 50526028 |
Gastrointestinal necrosis | 51.19 | 13.43 | 37 | 73592 | 2561 | 50528934 |
Immune thrombocytopenia | 50.56 | 13.43 | 64 | 73565 | 8953 | 50522542 |
Splenomegaly | 50.15 | 13.43 | 66 | 73563 | 9594 | 50521901 |
Feeling abnormal | 49.52 | 13.43 | 66 | 73563 | 125426 | 50406069 |
Suicide attempt | 49.37 | 13.43 | 8 | 73621 | 51724 | 50479771 |
Subacute cutaneous lupus erythematosus | 49.34 | 13.43 | 34 | 73595 | 2181 | 50529314 |
Chills | 48.80 | 13.43 | 273 | 73356 | 96414 | 50435081 |
Carcinoembryonic antigen increased | 48.68 | 13.43 | 29 | 73600 | 1445 | 50530050 |
Tumour perforation | 48.64 | 13.43 | 14 | 73615 | 97 | 50531398 |
Breast cancer recurrent | 48.62 | 13.43 | 42 | 73587 | 3766 | 50527729 |
Colony stimulating factor therapy | 48.36 | 13.43 | 18 | 73611 | 300 | 50531195 |
Metastases to peritoneum | 48.33 | 13.43 | 37 | 73592 | 2796 | 50528699 |
Breast cancer metastatic | 48.02 | 13.43 | 67 | 73562 | 10297 | 50521198 |
Injury | 47.98 | 13.43 | 7 | 73622 | 48918 | 50482577 |
Fluid retention | 47.96 | 13.43 | 8 | 73621 | 50641 | 50480854 |
Agranulocytosis | 47.78 | 13.43 | 100 | 73529 | 21321 | 50510174 |
Stress | 47.72 | 13.43 | 10 | 73619 | 53783 | 50477712 |
Febrile bone marrow aplasia | 47.36 | 13.43 | 52 | 73577 | 6259 | 50525236 |
Colitis | 47.02 | 13.43 | 143 | 73486 | 38386 | 50493109 |
Gait disturbance | 46.89 | 13.43 | 92 | 73537 | 149913 | 50381582 |
Metastases to pleura | 46.56 | 13.43 | 27 | 73602 | 1279 | 50530216 |
Troponin I increased | 46.32 | 13.43 | 31 | 73598 | 1895 | 50529600 |
Duodenal ulcer perforation | 45.97 | 13.43 | 6 | 73623 | 45605 | 50485890 |
Female genital tract fistula | 45.93 | 13.43 | 40 | 73589 | 3626 | 50527869 |
Haemolytic uraemic syndrome | 45.63 | 13.43 | 33 | 73596 | 2286 | 50529209 |
Adverse drug reaction | 45.56 | 13.43 | 12 | 73617 | 55210 | 50476285 |
Myocarditis | 45.51 | 13.43 | 57 | 73572 | 7890 | 50523605 |
Myelodysplastic syndrome | 45.26 | 13.43 | 80 | 73549 | 15052 | 50516443 |
Cholinergic syndrome | 45.16 | 13.43 | 18 | 73611 | 364 | 50531131 |
Metastases to skin | 45.13 | 13.43 | 27 | 73602 | 1356 | 50530139 |
Injection site reaction | 45.01 | 13.43 | 9 | 73620 | 50023 | 50481472 |
Mucosal toxicity | 44.53 | 13.43 | 17 | 73612 | 305 | 50531190 |
Sleep disorder | 44.40 | 13.43 | 14 | 73615 | 57269 | 50474226 |
Malignant respiratory tract neoplasm | 43.04 | 13.43 | 11 | 73618 | 45 | 50531450 |
Administration site extravasation | 42.98 | 13.43 | 21 | 73608 | 700 | 50530795 |
Balance disorder | 42.42 | 13.43 | 25 | 73604 | 70565 | 50460930 |
Epistaxis | 42.39 | 13.43 | 195 | 73434 | 63759 | 50467736 |
Urticaria | 41.76 | 13.43 | 78 | 73551 | 129483 | 50402012 |
Steatohepatitis | 41.15 | 13.43 | 18 | 73611 | 463 | 50531032 |
Somnolence | 41.11 | 13.43 | 104 | 73525 | 154881 | 50376614 |
Injection site swelling | 40.91 | 13.43 | 6 | 73623 | 41767 | 50489728 |
Metastases to central nervous system | 40.88 | 13.43 | 65 | 73564 | 11217 | 50520278 |
COVID-19 | 40.73 | 13.43 | 9 | 73620 | 46653 | 50484842 |
Short-bowel syndrome | 40.71 | 13.43 | 17 | 73612 | 389 | 50531106 |
Asthma | 40.59 | 13.43 | 42 | 73587 | 89295 | 50442200 |
Trichomegaly | 40.14 | 13.43 | 10 | 73619 | 36 | 50531459 |
Embolism | 39.93 | 13.43 | 50 | 73579 | 6918 | 50524577 |
Nodular regenerative hyperplasia | 39.92 | 13.43 | 15 | 73614 | 257 | 50531238 |
Aortic thrombosis | 39.44 | 13.43 | 22 | 73607 | 967 | 50530528 |
Memory impairment | 38.73 | 13.43 | 35 | 73594 | 79325 | 50452170 |
Splenic artery thrombosis | 38.01 | 13.43 | 10 | 73619 | 47 | 50531448 |
Factor VII deficiency | 37.88 | 13.43 | 9 | 73620 | 25 | 50531470 |
Hypertensive crisis | 37.37 | 13.43 | 68 | 73561 | 13086 | 50518409 |
Proctalgia | 37.16 | 13.43 | 41 | 73588 | 4962 | 50526533 |
Septic shock | 36.91 | 13.43 | 173 | 73456 | 57002 | 50474493 |
Aplasia | 36.88 | 13.43 | 36 | 73593 | 3777 | 50527718 |
Hypophagia | 36.77 | 13.43 | 106 | 73523 | 27622 | 50503873 |
Blister | 36.76 | 13.43 | 42 | 73587 | 85376 | 50446119 |
Aortitis | 36.43 | 13.43 | 20 | 73609 | 852 | 50530643 |
Subileus | 36.39 | 13.43 | 31 | 73598 | 2728 | 50528767 |
Tumour ulceration | 36.30 | 13.43 | 12 | 73617 | 138 | 50531357 |
Rash | 36.20 | 13.43 | 435 | 73194 | 437036 | 50094459 |
Type 2 diabetes mellitus | 35.93 | 13.43 | 4 | 73625 | 34371 | 50497124 |
Dermatitis | 35.92 | 13.43 | 70 | 73559 | 14181 | 50517314 |
Cataract | 35.88 | 13.43 | 12 | 73617 | 47288 | 50484207 |
Hyperbilirubinaemia | 35.87 | 13.43 | 56 | 73573 | 9514 | 50521981 |
Wheezing | 35.86 | 13.43 | 23 | 73606 | 62024 | 50469471 |
Cystitis radiation | 35.69 | 13.43 | 10 | 73619 | 62 | 50531433 |
Dysaesthesia | 35.63 | 13.43 | 35 | 73594 | 3700 | 50527795 |
Venous pressure jugular decreased | 35.58 | 13.43 | 9 | 73620 | 35 | 50531460 |
Incorrect dose administered | 35.50 | 13.43 | 13 | 73616 | 48401 | 50483094 |
Infusion related hypersensitivity reaction | 35.29 | 13.43 | 10 | 73619 | 65 | 50531430 |
Overdose | 34.89 | 13.43 | 57 | 73572 | 99670 | 50431825 |
Hormone receptor positive breast cancer | 34.62 | 13.43 | 16 | 73613 | 470 | 50531025 |
Abortion spontaneous | 34.61 | 13.43 | 9 | 73620 | 41763 | 50489732 |
Bladder tamponade | 34.53 | 13.43 | 10 | 73619 | 71 | 50531424 |
Unevaluable event | 34.40 | 13.43 | 12 | 73617 | 46054 | 50485441 |
White blood cell count abnormal | 34.36 | 13.43 | 41 | 73588 | 5399 | 50526096 |
Nasal congestion | 33.82 | 13.43 | 16 | 73613 | 51104 | 50480391 |
Large intestinal obstruction | 33.43 | 13.43 | 25 | 73604 | 1824 | 50529671 |
Confusional state | 33.36 | 13.43 | 148 | 73481 | 185780 | 50345715 |
Miller Fisher syndrome | 32.95 | 13.43 | 10 | 73619 | 85 | 50531410 |
Jugular vein thrombosis | 32.94 | 13.43 | 29 | 73600 | 2667 | 50528828 |
Ocular toxicity | 32.87 | 13.43 | 16 | 73613 | 529 | 50530966 |
Neuromyotonia | 32.66 | 13.43 | 9 | 73620 | 52 | 50531443 |
Atypical haemolytic uraemic syndrome | 32.54 | 13.43 | 16 | 73613 | 541 | 50530954 |
Nephritis bacterial | 32.51 | 13.43 | 8 | 73621 | 27 | 50531468 |
Heart rate decreased | 31.93 | 13.43 | 7 | 73622 | 36490 | 50495005 |
Liver abscess | 31.90 | 13.43 | 28 | 73601 | 2565 | 50528930 |
Organising pneumonia | 31.84 | 13.43 | 37 | 73592 | 4737 | 50526758 |
Venoocclusive liver disease | 31.79 | 13.43 | 35 | 73594 | 4226 | 50527269 |
Sepsis | 31.67 | 13.43 | 314 | 73315 | 132611 | 50398884 |
Metastases to meninges | 31.66 | 13.43 | 25 | 73604 | 1977 | 50529518 |
Hepatic failure | 31.46 | 13.43 | 111 | 73518 | 32172 | 50499323 |
Acute lymphocytic leukaemia | 31.25 | 13.43 | 26 | 73603 | 2215 | 50529280 |
Rhabdomyolysis | 31.22 | 13.43 | 9 | 73620 | 39018 | 50492477 |
Hydrothorax | 31.18 | 13.43 | 17 | 73612 | 714 | 50530781 |
Sedation | 30.91 | 13.43 | 4 | 73625 | 30606 | 50500889 |
Stridor | 30.80 | 13.43 | 30 | 73599 | 3139 | 50528356 |
Cough | 30.76 | 13.43 | 215 | 73414 | 241049 | 50290446 |
Hypertension | 30.63 | 13.43 | 454 | 73175 | 210749 | 50320746 |
Anastomotic leak | 30.58 | 13.43 | 14 | 73615 | 402 | 50531093 |
Venous thrombosis | 30.44 | 13.43 | 35 | 73594 | 4431 | 50527064 |
Toxic leukoencephalopathy | 30.36 | 13.43 | 16 | 73613 | 627 | 50530868 |
Wrong technique in product usage process | 30.18 | 13.43 | 22 | 73607 | 55488 | 50476007 |
Osteonecrosis of jaw | 30.13 | 13.43 | 110 | 73519 | 32416 | 50499079 |
Skin fissures | 30.12 | 13.43 | 49 | 73580 | 8619 | 50522876 |
Thrombocytopenic purpura | 29.83 | 13.43 | 20 | 73609 | 1226 | 50530269 |
Renal salt-wasting syndrome | 29.82 | 13.43 | 12 | 73617 | 249 | 50531246 |
Vena cava thrombosis | 29.33 | 13.43 | 24 | 73605 | 1997 | 50529498 |
Red blood cell sedimentation rate increased | 29.33 | 13.43 | 4 | 73625 | 29412 | 50502083 |
Device related infection | 29.19 | 13.43 | 81 | 73548 | 20654 | 50510841 |
Dysgeusia | 29.07 | 13.43 | 123 | 73506 | 38793 | 50492702 |
Small intestinal obstruction | 29.07 | 13.43 | 69 | 73560 | 15999 | 50515496 |
Nicotinic acid deficiency | 29.07 | 13.43 | 8 | 73621 | 46 | 50531449 |
Metastases to reproductive organ | 29.06 | 13.43 | 6 | 73623 | 6 | 50531489 |
Rash pustular | 28.70 | 13.43 | 41 | 73588 | 6440 | 50525055 |
Cachexia | 28.36 | 13.43 | 34 | 73595 | 4499 | 50526996 |
Malignant pleural effusion | 28.34 | 13.43 | 25 | 73604 | 2305 | 50529190 |
Ileal perforation | 28.31 | 13.43 | 13 | 73616 | 376 | 50531119 |
Upper respiratory tract infection | 27.71 | 13.43 | 33 | 73596 | 65865 | 50465630 |
Dry skin | 27.37 | 13.43 | 130 | 73499 | 43061 | 50488434 |
Encephalopathy | 27.11 | 13.43 | 109 | 73520 | 33602 | 50497893 |
Acute abdomen | 27.02 | 13.43 | 20 | 73609 | 1436 | 50530059 |
Conjunctival filtering bleb leak | 26.97 | 13.43 | 6 | 73623 | 11 | 50531484 |
Intentional product use issue | 26.87 | 13.43 | 44 | 73585 | 76874 | 50454621 |
ECG signs of myocardial ischaemia | 26.57 | 13.43 | 8 | 73621 | 66 | 50531429 |
Gastrooesophageal reflux disease | 26.44 | 13.43 | 44 | 73585 | 76384 | 50455111 |
Metastases to ovary | 26.43 | 13.43 | 12 | 73617 | 338 | 50531157 |
Bradycardia | 26.31 | 13.43 | 33 | 73596 | 64393 | 50467102 |
Emotional distress | 26.11 | 13.43 | 5 | 73624 | 28658 | 50502837 |
Metastases to spine | 26.03 | 13.43 | 26 | 73603 | 2805 | 50528690 |
Throat tightness | 26.02 | 13.43 | 78 | 73551 | 20769 | 50510726 |
Metastases to the mediastinum | 25.97 | 13.43 | 13 | 73616 | 457 | 50531038 |
Tumour necrosis | 25.70 | 13.43 | 15 | 73614 | 719 | 50530776 |
Cardiac ventricular thrombosis | 25.56 | 13.43 | 13 | 73616 | 473 | 50531022 |
Subclavian vein thrombosis | 25.35 | 13.43 | 21 | 73608 | 1778 | 50529717 |
Aortic dissection | 25.31 | 13.43 | 20 | 73609 | 1583 | 50529912 |
Acute interstitial pneumonitis | 25.23 | 13.43 | 14 | 73615 | 609 | 50530886 |
Inferior vena cava stenosis | 25.17 | 13.43 | 6 | 73623 | 17 | 50531478 |
Urinary tract infection | 25.06 | 13.43 | 207 | 73422 | 223813 | 50307682 |
Therapy cessation | 24.86 | 13.43 | 4 | 73625 | 26007 | 50505488 |
Soft tissue necrosis | 24.81 | 13.43 | 12 | 73617 | 391 | 50531104 |
Blood creatine increased | 24.77 | 13.43 | 33 | 73596 | 4854 | 50526641 |
Tumour lysis syndrome | 24.51 | 13.43 | 41 | 73588 | 7380 | 50524115 |
Respiratory failure | 24.50 | 13.43 | 221 | 73408 | 90960 | 50440535 |
Myocardial ischaemia | 24.49 | 13.43 | 53 | 73576 | 11560 | 50519935 |
Osteonecrosis | 24.20 | 13.43 | 80 | 73549 | 22437 | 50509058 |
Gastrointestinal stoma complication | 24.19 | 13.43 | 19 | 73610 | 1491 | 50530004 |
Enterocolitis | 24.02 | 13.43 | 38 | 73591 | 6529 | 50524966 |
Vision blurred | 23.90 | 13.43 | 49 | 73580 | 78598 | 50452897 |
Pleural effusion | 23.74 | 13.43 | 201 | 73428 | 81253 | 50450242 |
Nasal septum perforation | 23.73 | 13.43 | 14 | 73615 | 685 | 50530810 |
Diaphragmatic paralysis | 23.72 | 13.43 | 13 | 73616 | 552 | 50530943 |
Encapsulating peritoneal sclerosis | 23.68 | 13.43 | 11 | 73618 | 327 | 50531168 |
Hepatic lesion | 23.35 | 13.43 | 29 | 73600 | 3979 | 50527516 |
Hypocapnia | 23.34 | 13.43 | 11 | 73618 | 338 | 50531157 |
Catabolic state | 23.33 | 13.43 | 7 | 73622 | 57 | 50531438 |
Pregnancy | 23.33 | 13.43 | 7 | 73622 | 29570 | 50501925 |
Electrocardiogram ST segment elevation | 23.30 | 13.43 | 27 | 73602 | 3446 | 50528049 |
Gastric disorder | 23.30 | 13.43 | 7 | 73622 | 29541 | 50501954 |
Product quality issue | 23.11 | 13.43 | 8 | 73621 | 30850 | 50500645 |
Tonic clonic movements | 22.98 | 13.43 | 17 | 73612 | 1220 | 50530275 |
Adverse event | 22.95 | 13.43 | 18 | 73611 | 43745 | 50487750 |
Aortic intramural haematoma | 22.91 | 13.43 | 7 | 73622 | 61 | 50531434 |
Stomatitis haemorrhagic | 22.84 | 13.43 | 6 | 73623 | 28 | 50531467 |
Pelvic abscess | 22.83 | 13.43 | 18 | 73611 | 1420 | 50530075 |
Tympanic membrane disorder | 22.76 | 13.43 | 9 | 73620 | 178 | 50531317 |
Acute leukaemia | 22.70 | 13.43 | 16 | 73613 | 1064 | 50530431 |
Ear infection | 22.68 | 13.43 | 5 | 73624 | 25965 | 50505530 |
Oesophagitis | 22.64 | 13.43 | 56 | 73573 | 13327 | 50518168 |
Platelet count decreased | 22.57 | 13.43 | 235 | 73394 | 100491 | 50431004 |
Xerosis | 22.26 | 13.43 | 13 | 73616 | 624 | 50530871 |
Type II hypersensitivity | 22.19 | 13.43 | 5 | 73624 | 10 | 50531485 |
Cardiomyopathy acute | 22.13 | 13.43 | 9 | 73620 | 192 | 50531303 |
Hypervolaemia | 22.09 | 13.43 | 5 | 73624 | 25494 | 50506001 |
Adenocarcinoma of colon | 22.02 | 13.43 | 21 | 73608 | 2141 | 50529354 |
Irritability | 21.93 | 13.43 | 7 | 73622 | 28419 | 50503076 |
Gastrointestinal stoma output increased | 21.92 | 13.43 | 9 | 73620 | 197 | 50531298 |
Recurrent cancer | 21.67 | 13.43 | 19 | 73610 | 1738 | 50529757 |
Pulmonary alveolar haemorrhage | 21.66 | 13.43 | 28 | 73601 | 3999 | 50527496 |
Portal vein thrombosis | 21.61 | 13.43 | 21 | 73608 | 2191 | 50529304 |
Tumour haemorrhage | 21.60 | 13.43 | 17 | 73612 | 1338 | 50530157 |
Amnesia | 21.39 | 13.43 | 18 | 73611 | 42242 | 50489253 |
Depilation | 21.29 | 13.43 | 5 | 73624 | 13 | 50531482 |
Nephrolithiasis | 21.25 | 13.43 | 12 | 73617 | 34681 | 50496814 |
Left ventricular dilatation | 21.21 | 13.43 | 11 | 73618 | 417 | 50531078 |
Recall phenomenon | 21.17 | 13.43 | 12 | 73617 | 544 | 50530951 |
Blood pressure fluctuation | 21.08 | 13.43 | 13 | 73616 | 35810 | 50495685 |
Radiation skin injury | 21.02 | 13.43 | 14 | 73615 | 849 | 50530646 |
Aorto-oesophageal fistula | 21.02 | 13.43 | 5 | 73624 | 14 | 50531481 |
Duodenal perforation | 20.77 | 13.43 | 13 | 73616 | 708 | 50530787 |
Gait apraxia | 20.76 | 13.43 | 5 | 73624 | 15 | 50531480 |
Myeloproliferative neoplasm | 20.33 | 13.43 | 11 | 73618 | 455 | 50531040 |
Hyperkalaemia | 20.30 | 13.43 | 24 | 73605 | 48065 | 50483430 |
K-ras gene mutation | 20.29 | 13.43 | 5 | 73624 | 17 | 50531478 |
Rectal cancer recurrent | 20.29 | 13.43 | 5 | 73624 | 17 | 50531478 |
Hypocalcaemia | 20.22 | 13.43 | 85 | 73544 | 26731 | 50504764 |
Carbohydrate antigen 19-9 increased | 20.20 | 13.43 | 8 | 73621 | 159 | 50531336 |
Chronic myeloid leukaemia | 20.19 | 13.43 | 20 | 73609 | 2136 | 50529359 |
Oral pain | 20.18 | 13.43 | 81 | 73548 | 24952 | 50506543 |
Coronary artery disease | 20.13 | 13.43 | 9 | 73620 | 29717 | 50501778 |
Protein urine | 20.10 | 13.43 | 12 | 73617 | 600 | 50530895 |
Acute coronary syndrome | 20.02 | 13.43 | 43 | 73586 | 9331 | 50522164 |
Xerophthalmia | 20.02 | 13.43 | 10 | 73619 | 350 | 50531145 |
Hallucination | 20.01 | 13.43 | 23 | 73606 | 46634 | 50484861 |
Pigmentation disorder | 19.98 | 13.43 | 26 | 73603 | 3738 | 50527757 |
Renal tubular disorder | 19.90 | 13.43 | 21 | 73608 | 2416 | 50529079 |
Blood phosphorus decreased | 19.84 | 13.43 | 26 | 73603 | 3763 | 50527732 |
Pelvic fluid collection | 19.79 | 13.43 | 13 | 73616 | 770 | 50530725 |
Gait inability | 19.71 | 13.43 | 15 | 73614 | 37012 | 50494483 |
Gastric varices haemorrhage | 19.61 | 13.43 | 7 | 73622 | 103 | 50531392 |
Adenocarcinoma | 19.59 | 13.43 | 21 | 73608 | 2460 | 50529035 |
Heart rate increased | 19.58 | 13.43 | 53 | 73576 | 77197 | 50454298 |
Tumour marker increased | 19.57 | 13.43 | 26 | 73603 | 3814 | 50527681 |
Dyskinesia | 19.56 | 13.43 | 8 | 73621 | 27853 | 50503642 |
Visual impairment | 19.53 | 13.43 | 44 | 73585 | 68231 | 50463264 |
Folliculitis | 19.49 | 13.43 | 17 | 73612 | 39208 | 50492287 |
Gastrointestinal anastomotic leak | 19.49 | 13.43 | 8 | 73621 | 175 | 50531320 |
Psychotic disorder | 19.46 | 13.43 | 4 | 73625 | 21808 | 50509687 |
Foot fracture | 19.41 | 13.43 | 3 | 73626 | 20088 | 50511407 |
Varices oesophageal | 19.25 | 13.43 | 22 | 73607 | 2767 | 50528728 |
Wernicke's encephalopathy | 19.09 | 13.43 | 5 | 73624 | 23 | 50531472 |
Fistula | 19.07 | 13.43 | 39 | 73590 | 8179 | 50523316 |
Fistula of small intestine | 18.91 | 13.43 | 9 | 73620 | 283 | 50531212 |
Vaginal fistula | 18.91 | 13.43 | 10 | 73619 | 395 | 50531100 |
Oesophageal varices haemorrhage | 18.78 | 13.43 | 14 | 73615 | 1016 | 50530479 |
Road traffic accident | 18.78 | 13.43 | 6 | 73623 | 24346 | 50507149 |
Vesical fistula | 18.73 | 13.43 | 6 | 73623 | 62 | 50531433 |
Colon cancer metastatic | 18.66 | 13.43 | 14 | 73615 | 1026 | 50530469 |
No adverse event | 18.65 | 13.43 | 13 | 73616 | 33565 | 50497930 |
Night sweats | 18.65 | 13.43 | 13 | 73616 | 33561 | 50497934 |
Portal vein dilatation | 18.59 | 13.43 | 5 | 73624 | 26 | 50531469 |
Aggression | 18.57 | 13.43 | 4 | 73625 | 21112 | 50510383 |
Productive cough | 18.53 | 13.43 | 30 | 73599 | 52664 | 50478831 |
Anastomotic complication | 18.52 | 13.43 | 7 | 73622 | 122 | 50531373 |
Head injury | 18.38 | 13.43 | 6 | 73623 | 24014 | 50507481 |
Osteoporosis | 18.31 | 13.43 | 23 | 73606 | 44856 | 50486639 |
Erythema | 18.27 | 13.43 | 307 | 73322 | 146107 | 50385388 |
Rib fracture | 18.27 | 13.43 | 3 | 73626 | 19218 | 50512277 |
Retroperitoneal abscess | 18.21 | 13.43 | 7 | 73622 | 128 | 50531367 |
Toxic cardiomyopathy | 18.16 | 13.43 | 7 | 73622 | 129 | 50531366 |
Necrosis | 18.15 | 13.43 | 28 | 73601 | 4708 | 50526787 |
Biliary tract infection | 18.13 | 13.43 | 10 | 73619 | 430 | 50531065 |
Cardiac myxoma | 18.07 | 13.43 | 8 | 73621 | 212 | 50531283 |
Blood pressure systolic increased | 18.06 | 13.43 | 15 | 73614 | 35434 | 50496061 |
Neutrophil count abnormal | 18.00 | 13.43 | 20 | 73609 | 2439 | 50529056 |
Multiple organ dysfunction syndrome | 17.86 | 13.43 | 130 | 73499 | 50207 | 50481288 |
Chemical burns of eye | 17.85 | 13.43 | 6 | 73623 | 73 | 50531422 |
Liver function test abnormal | 17.80 | 13.43 | 23 | 73606 | 44316 | 50487179 |
Multiple sclerosis | 17.79 | 13.43 | 4 | 73625 | 20489 | 50511006 |
Hyperpyrexia | 17.67 | 13.43 | 22 | 73607 | 3027 | 50528468 |
Treatment noncompliance | 17.66 | 13.43 | 11 | 73618 | 30139 | 50501356 |
Hepatic vein stenosis | 17.58 | 13.43 | 5 | 73624 | 33 | 50531462 |
Ill-defined disorder | 17.51 | 13.43 | 33 | 73596 | 54621 | 50476874 |
Splenic marginal zone lymphoma recurrent | 17.44 | 13.43 | 4 | 73625 | 9 | 50531486 |
Marchiafava-Bignami disease | 17.44 | 13.43 | 4 | 73625 | 9 | 50531486 |
Respiratory disorder | 17.42 | 13.43 | 12 | 73617 | 31175 | 50500320 |
Anal inflammation | 17.41 | 13.43 | 7 | 73622 | 145 | 50531350 |
Joint range of motion decreased | 17.35 | 13.43 | 3 | 73626 | 18509 | 50512986 |
Illness | 17.31 | 13.43 | 7 | 73622 | 24533 | 50506962 |
Blood glucose increased | 17.28 | 13.43 | 50 | 73579 | 71274 | 50460221 |
Cutaneous tuberculosis | 17.19 | 13.43 | 7 | 73622 | 150 | 50531345 |
Vasospasm | 17.17 | 13.43 | 11 | 73618 | 624 | 50530871 |
Diabetes mellitus | 17.17 | 13.43 | 28 | 73601 | 49005 | 50482490 |
Menopause | 17.16 | 13.43 | 19 | 73610 | 2308 | 50529187 |
Dysphonia | 17.14 | 13.43 | 106 | 73523 | 38786 | 50492709 |
Device issue | 17.13 | 13.43 | 4 | 73625 | 19968 | 50511527 |
SAPHO syndrome | 17.08 | 13.43 | 6 | 73623 | 84 | 50531411 |
Palpitations | 17.07 | 13.43 | 75 | 73554 | 94431 | 50437064 |
Pulmonary artery thrombosis | 16.98 | 13.43 | 11 | 73618 | 636 | 50530859 |
Pneumatosis intestinalis | 16.96 | 13.43 | 18 | 73611 | 2085 | 50529410 |
Venous thrombosis limb | 16.95 | 13.43 | 20 | 73609 | 2602 | 50528893 |
Intercepted product administration error | 16.89 | 13.43 | 6 | 73623 | 87 | 50531408 |
Endocardial fibrosis | 16.87 | 13.43 | 4 | 73625 | 11 | 50531484 |
Localised infection | 16.82 | 13.43 | 8 | 73621 | 25477 | 50506018 |
Malignant peritoneal neoplasm | 16.77 | 13.43 | 11 | 73618 | 650 | 50530845 |
International normalised ratio increased | 16.70 | 13.43 | 23 | 73606 | 43129 | 50488366 |
Ocular vasculitis | 16.64 | 13.43 | 5 | 73624 | 41 | 50531454 |
Endometrial dysplasia | 16.61 | 13.43 | 4 | 73625 | 12 | 50531483 |
Vascular access site swelling | 16.60 | 13.43 | 3 | 73626 | 0 | 50531495 |
Percussion test abnormal | 16.60 | 13.43 | 3 | 73626 | 0 | 50531495 |
Dandy-Walker syndrome | 16.58 | 13.43 | 6 | 73623 | 92 | 50531403 |
Tongue oedema | 16.58 | 13.43 | 24 | 73605 | 3815 | 50527680 |
Proctitis | 16.44 | 13.43 | 17 | 73612 | 1911 | 50529584 |
Monoparesis | 16.41 | 13.43 | 15 | 73614 | 1449 | 50530046 |
Gastric perforation | 16.36 | 13.43 | 15 | 73614 | 1455 | 50530040 |
Skin exfoliation | 16.34 | 13.43 | 94 | 73535 | 33518 | 50497977 |
Blood creatine phosphokinase increased | 16.32 | 13.43 | 9 | 73620 | 26358 | 50505137 |
Multiple-drug resistance | 16.22 | 13.43 | 22 | 73607 | 3292 | 50528203 |
Withdrawal syndrome | 16.17 | 13.43 | 3 | 73626 | 17587 | 50513908 |
Intravascular haemolysis | 16.15 | 13.43 | 8 | 73621 | 275 | 50531220 |
Bursitis | 16.13 | 13.43 | 6 | 73623 | 22129 | 50509366 |
Colon cancer recurrent | 16.03 | 13.43 | 5 | 73624 | 47 | 50531448 |
Full blood count abnormal | 15.97 | 13.43 | 7 | 73622 | 23381 | 50508114 |
Malignant neoplasm of pleura | 15.94 | 13.43 | 5 | 73624 | 48 | 50531447 |
Portal shunt | 15.93 | 13.43 | 4 | 73625 | 15 | 50531480 |
Cerebral infarction | 15.91 | 13.43 | 68 | 73561 | 21536 | 50509959 |
Vitamin B1 deficiency | 15.78 | 13.43 | 8 | 73621 | 289 | 50531206 |
T-cell type acute leukaemia | 15.76 | 13.43 | 5 | 73624 | 50 | 50531445 |
Duodenal ulcer | 15.54 | 13.43 | 32 | 73597 | 6743 | 50524752 |
Cardiogenic shock | 15.51 | 13.43 | 54 | 73575 | 15545 | 50515950 |
Carbohydrate antigen 15-3 increased | 15.51 | 13.43 | 13 | 73616 | 1119 | 50530376 |
Hypertensive encephalopathy | 15.51 | 13.43 | 10 | 73619 | 574 | 50530921 |
Herpes zoster | 15.47 | 13.43 | 52 | 73577 | 70734 | 50460761 |
Depressed mood | 15.44 | 13.43 | 16 | 73613 | 34007 | 50497488 |
Herpes simplex encephalitis | 15.41 | 13.43 | 8 | 73621 | 304 | 50531191 |
Anaemia of malignant disease | 15.39 | 13.43 | 9 | 73620 | 433 | 50531062 |
Performance status decreased | 15.32 | 13.43 | 21 | 73608 | 3174 | 50528321 |
Chemotherapy | 15.29 | 13.43 | 14 | 73615 | 1355 | 50530140 |
Joint stiffness | 15.23 | 13.43 | 13 | 73616 | 30295 | 50501200 |
Acute pulmonary oedema | 15.14 | 13.43 | 33 | 73596 | 7234 | 50524261 |
Obesity | 15.12 | 13.43 | 3 | 73626 | 16772 | 50514723 |
Surgery | 15.12 | 13.43 | 13 | 73616 | 30192 | 50501303 |
Superior vena cava syndrome | 15.11 | 13.43 | 10 | 73619 | 600 | 50530895 |
Thrombotic microangiopathy | 15.10 | 13.43 | 37 | 73592 | 8754 | 50522741 |
Hypophosphataemia | 15.08 | 13.43 | 36 | 73593 | 8378 | 50523117 |
Tendonitis | 15.03 | 13.43 | 3 | 73626 | 16702 | 50514793 |
Gastrointestinal motility disorder | 15.01 | 13.43 | 25 | 73604 | 4484 | 50527011 |
Hyperthermia | 14.96 | 13.43 | 34 | 73595 | 7662 | 50523833 |
Bone marrow infiltration | 14.92 | 13.43 | 9 | 73620 | 459 | 50531036 |
Pulmonary toxicity | 14.85 | 13.43 | 28 | 73601 | 5534 | 50525961 |
Acute polyneuropathy | 14.83 | 13.43 | 7 | 73622 | 216 | 50531279 |
Metastases to chest wall | 14.74 | 13.43 | 9 | 73620 | 469 | 50531026 |
Nail disorder | 14.74 | 13.43 | 39 | 73590 | 9669 | 50521826 |
Hydronephrosis | 14.72 | 13.43 | 36 | 73593 | 8505 | 50522990 |
Red blood cell nucleated morphology present | 14.68 | 13.43 | 4 | 73625 | 22 | 50531473 |
Anal fistula | 14.65 | 13.43 | 19 | 73610 | 2723 | 50528772 |
Tumour obstruction | 14.53 | 13.43 | 3 | 73626 | 3 | 50531492 |
Pulmonary fistula | 14.53 | 13.43 | 3 | 73626 | 3 | 50531492 |
Haemolysis | 14.50 | 13.43 | 29 | 73600 | 5987 | 50525508 |
Musculoskeletal pain | 14.46 | 13.43 | 55 | 73574 | 72122 | 50459373 |
Intestinal ischaemia | 14.44 | 13.43 | 31 | 73598 | 6726 | 50524769 |
Systolic dysfunction | 14.43 | 13.43 | 14 | 73615 | 1458 | 50530037 |
Extrasystoles | 14.42 | 13.43 | 25 | 73604 | 4630 | 50526865 |
Abdominal abscess | 14.39 | 13.43 | 23 | 73606 | 3985 | 50527510 |
Enterocolitis infectious | 14.38 | 13.43 | 14 | 73615 | 1464 | 50530031 |
Mental disorder | 14.36 | 13.43 | 7 | 73622 | 21984 | 50509511 |
Spinal cord compression | 14.32 | 13.43 | 22 | 73607 | 3687 | 50527808 |
Skin disorder | 14.27 | 13.43 | 71 | 73558 | 23959 | 50507536 |
Dysphagia | 14.25 | 13.43 | 174 | 73455 | 77344 | 50454151 |
Metastases to pelvis | 14.23 | 13.43 | 8 | 73621 | 357 | 50531138 |
Dysaesthesia pharynx | 14.18 | 13.43 | 6 | 73623 | 142 | 50531353 |
Metastases to neck | 14.17 | 13.43 | 5 | 73624 | 71 | 50531424 |
Arterial thrombosis | 14.15 | 13.43 | 13 | 73616 | 1264 | 50530231 |
Periodontal disease | 14.13 | 13.43 | 14 | 73615 | 1496 | 50529999 |
Nasal crusting | 14.12 | 13.43 | 7 | 73622 | 241 | 50531254 |
Anal erosion | 14.12 | 13.43 | 4 | 73625 | 26 | 50531469 |
Accidental exposure to product | 14.08 | 13.43 | 8 | 73621 | 23049 | 50508446 |
Scintillating scotoma | 14.06 | 13.43 | 6 | 73623 | 145 | 50531350 |
Oesophageal stenosis | 14.03 | 13.43 | 19 | 73610 | 2839 | 50528656 |
Restless legs syndrome | 14.01 | 13.43 | 3 | 73626 | 15894 | 50515601 |
Small intestinal perforation | 13.97 | 13.43 | 13 | 73616 | 1285 | 50530210 |
Gingival atrophy | 13.86 | 13.43 | 4 | 73625 | 28 | 50531467 |
Neck pain | 13.83 | 13.43 | 40 | 73589 | 57027 | 50474468 |
Therapy interrupted | 13.81 | 13.43 | 6 | 73623 | 20146 | 50511349 |
Hepatic cytolysis | 13.80 | 13.43 | 34 | 73595 | 8069 | 50523426 |
Ankle fracture | 13.78 | 13.43 | 3 | 73626 | 15719 | 50515776 |
Onycholysis | 13.72 | 13.43 | 13 | 73616 | 1315 | 50530180 |
Hypermetabolism | 13.69 | 13.43 | 6 | 73623 | 155 | 50531340 |
Eosinophilia | 13.68 | 13.43 | 5 | 73624 | 18647 | 50512848 |
Transaminases increased | 13.65 | 13.43 | 78 | 73551 | 27746 | 50503749 |
HER2 gene amplification | 13.62 | 13.43 | 4 | 73625 | 30 | 50531465 |
Product intolerance | 13.62 | 13.43 | 4 | 73625 | 30 | 50531465 |
Enterobacter sepsis | 13.58 | 13.43 | 7 | 73622 | 262 | 50531233 |
Dry eye | 13.57 | 13.43 | 16 | 73613 | 32079 | 50499416 |
Drug ineffective for unapproved indication | 13.56 | 13.43 | 7 | 73622 | 21274 | 50510221 |
Bronchospasm | 13.56 | 13.43 | 50 | 73579 | 14804 | 50516691 |
Peripheral nerve injury | 13.51 | 13.43 | 8 | 73621 | 394 | 50531101 |
Back pain | 13.48 | 13.43 | 232 | 73397 | 219798 | 50311697 |
Thrombotic thrombocytopenic purpura | 13.47 | 13.43 | 21 | 73608 | 3564 | 50527931 |
MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
---|---|---|---|---|---|---|
Neutropenia | 1206.12 | 13.44 | 1661 | 81884 | 130050 | 29360932 |
Diarrhoea | 947.84 | 13.44 | 2547 | 80998 | 330151 | 29160831 |
Dermatitis acneiform | 861.39 | 13.44 | 383 | 83162 | 5108 | 29485874 |
Neuropathy peripheral | 737.47 | 13.44 | 954 | 82591 | 70073 | 29420909 |
Mucosal inflammation | 727.74 | 13.44 | 648 | 82897 | 30947 | 29460035 |
Stomatitis | 583.01 | 13.44 | 617 | 82928 | 36496 | 29454486 |
Skin toxicity | 549.91 | 13.44 | 250 | 83295 | 3521 | 29487461 |
Arteriospasm coronary | 501.13 | 13.44 | 209 | 83336 | 2356 | 29488626 |
Disease progression | 496.17 | 13.44 | 855 | 82690 | 81061 | 29409921 |
Palmar-plantar erythrodysaesthesia syndrome | 445.47 | 13.44 | 354 | 83191 | 14405 | 29476577 |
Paronychia | 437.62 | 13.44 | 198 | 83347 | 2755 | 29488227 |
Thrombocytopenia | 424.23 | 13.44 | 1075 | 82470 | 133748 | 29357234 |
Interstitial lung disease | 359.09 | 13.44 | 610 | 82935 | 57108 | 29433874 |
Neurotoxicity | 344.67 | 13.44 | 304 | 83241 | 14309 | 29476673 |
Leukopenia | 336.24 | 13.44 | 578 | 82967 | 54625 | 29436357 |
Metastases to liver | 335.74 | 13.44 | 274 | 83271 | 11582 | 29479400 |
Decreased appetite | 289.52 | 13.44 | 985 | 82560 | 144357 | 29346625 |
Nausea | 268.60 | 13.44 | 1559 | 81986 | 287696 | 29203286 |
Febrile neutropenia | 255.16 | 13.44 | 796 | 82749 | 111444 | 29379538 |
Peripheral sensory neuropathy | 254.61 | 13.44 | 176 | 83369 | 5763 | 29485219 |
Vomiting | 242.11 | 13.44 | 1211 | 82334 | 211049 | 29279933 |
Drug ineffective | 229.46 | 13.44 | 424 | 83121 | 362746 | 29128236 |
Hyperammonaemia | 229.18 | 13.44 | 162 | 83383 | 5501 | 29485481 |
Completed suicide | 226.81 | 13.44 | 6 | 83539 | 90240 | 29400742 |
Cardiotoxicity | 211.43 | 13.44 | 144 | 83401 | 4600 | 29486382 |
Proteinuria | 210.22 | 13.44 | 241 | 83304 | 15563 | 29475419 |
Gastrointestinal toxicity | 209.89 | 13.44 | 108 | 83437 | 2023 | 29488959 |
Gastrointestinal perforation | 205.21 | 13.44 | 126 | 83419 | 3357 | 29487625 |
Bone marrow failure | 194.68 | 13.44 | 308 | 83237 | 27141 | 29463841 |
Metastases to lung | 194.41 | 13.44 | 168 | 83377 | 7687 | 29483295 |
Drug interaction | 193.83 | 13.44 | 164 | 83381 | 197221 | 29293761 |
Arthralgia | 184.20 | 13.44 | 82 | 83463 | 139535 | 29351447 |
Polyneuropathy | 183.44 | 13.44 | 198 | 83347 | 11954 | 29479028 |
Hyperammonaemic encephalopathy | 182.09 | 13.44 | 96 | 83449 | 1894 | 29489088 |
Hypomagnesaemia | 178.21 | 13.44 | 233 | 83312 | 17235 | 29473747 |
General physical health deterioration | 175.35 | 13.44 | 663 | 82882 | 102194 | 29388788 |
Product dose omission issue | 174.26 | 13.44 | 31 | 83514 | 96352 | 29394630 |
Dehydration | 171.73 | 13.44 | 710 | 82835 | 114038 | 29376944 |
Alopecia | 163.62 | 13.44 | 234 | 83311 | 18850 | 29472132 |
Intestinal obstruction | 153.12 | 13.44 | 228 | 83317 | 19049 | 29471933 |
Neutrophil count decreased | 153.05 | 13.44 | 363 | 83182 | 43204 | 29447778 |
Skin reaction | 150.74 | 13.44 | 114 | 83431 | 4303 | 29486679 |
Portal hypertension | 137.07 | 13.44 | 98 | 83447 | 3388 | 29487594 |
Pneumatosis intestinalis | 133.68 | 13.44 | 93 | 83452 | 3076 | 29487906 |
Fall | 129.01 | 13.44 | 188 | 83357 | 176990 | 29313992 |
Headache | 127.32 | 13.44 | 184 | 83361 | 173823 | 29317159 |
Carcinoembryonic antigen increased | 125.77 | 13.44 | 52 | 83493 | 572 | 29490410 |
Abdominal pain | 119.36 | 13.44 | 721 | 82824 | 134636 | 29356346 |
Enteritis | 119.26 | 13.44 | 120 | 83425 | 6671 | 29484311 |
Pyrexia | 118.82 | 13.44 | 1287 | 82258 | 286335 | 29204647 |
Myelosuppression | 116.87 | 13.44 | 158 | 83387 | 12069 | 29478913 |
Portal venous gas | 113.41 | 13.44 | 41 | 83504 | 303 | 29490679 |
Pulmonary embolism | 108.45 | 13.44 | 466 | 83079 | 76068 | 29414914 |
Neoplasm progression | 108.08 | 13.44 | 191 | 83354 | 18421 | 29472561 |
Paraesthesia | 107.75 | 13.44 | 366 | 83179 | 53479 | 29437503 |
Rhabdomyolysis | 106.78 | 13.44 | 21 | 83524 | 60787 | 29430195 |
Cardiac failure congestive | 105.67 | 13.44 | 42 | 83503 | 76539 | 29414443 |
Myalgia | 104.78 | 13.44 | 39 | 83506 | 73980 | 29417002 |
Anxiety | 103.59 | 13.44 | 56 | 83489 | 85309 | 29405673 |
Malignant neoplasm progression | 101.04 | 13.44 | 445 | 83100 | 73414 | 29417568 |
Haematotoxicity | 100.82 | 13.44 | 109 | 83436 | 6590 | 29484392 |
Weight increased | 99.48 | 13.44 | 46 | 83499 | 76621 | 29414361 |
Chills | 98.61 | 13.44 | 431 | 83114 | 70869 | 29420113 |
Somnolence | 97.12 | 13.44 | 74 | 83471 | 93881 | 29397101 |
Ileus | 94.43 | 13.44 | 156 | 83389 | 14246 | 29476736 |
Peritonitis | 93.76 | 13.44 | 158 | 83387 | 14666 | 29476316 |
Depression | 91.98 | 13.44 | 64 | 83481 | 85083 | 29405899 |
Hospitalisation | 91.84 | 13.44 | 11 | 83534 | 45977 | 29445005 |
Hiccups | 87.04 | 13.44 | 116 | 83429 | 8737 | 29482245 |
Tumour necrosis | 85.03 | 13.44 | 48 | 83497 | 1089 | 29489893 |
Rash pustular | 84.40 | 13.44 | 84 | 83461 | 4607 | 29486375 |
Death | 82.66 | 13.44 | 597 | 82948 | 341487 | 29149495 |
Extravasation | 82.31 | 13.44 | 54 | 83491 | 1618 | 29489364 |
Oesophageal fistula | 82.27 | 13.44 | 28 | 83517 | 169 | 29490813 |
Insomnia | 80.68 | 13.44 | 79 | 83466 | 88682 | 29402300 |
Aggression | 80.46 | 13.44 | 5 | 83540 | 35536 | 29455446 |
Anastomotic complication | 76.89 | 13.44 | 31 | 83514 | 318 | 29490664 |
Toxicity to various agents | 76.53 | 13.44 | 244 | 83301 | 173417 | 29317565 |
Pelvic abscess | 75.81 | 13.44 | 41 | 83504 | 853 | 29490129 |
Ileal perforation | 75.69 | 13.44 | 38 | 83507 | 674 | 29490308 |
Pain in extremity | 75.64 | 13.44 | 122 | 83423 | 110311 | 29380671 |
Electrocardiogram ST segment elevation | 74.55 | 13.44 | 77 | 83468 | 4415 | 29486567 |
Small intestinal obstruction | 74.49 | 13.44 | 133 | 83412 | 12928 | 29478054 |
Overdose | 73.74 | 13.44 | 70 | 83475 | 79749 | 29411233 |
Hypokalaemia | 73.63 | 13.44 | 309 | 83236 | 49894 | 29441088 |
Large intestine perforation | 73.27 | 13.44 | 97 | 83448 | 7259 | 29483723 |
Anastomotic leak | 72.89 | 13.44 | 35 | 83510 | 561 | 29490421 |
Peripheral swelling | 72.77 | 13.44 | 45 | 83500 | 63694 | 29427288 |
Suicidal ideation | 72.64 | 13.44 | 7 | 83538 | 34709 | 29456273 |
Subileus | 72.63 | 13.44 | 62 | 83483 | 2788 | 29488194 |
Intentional product misuse | 72.50 | 13.44 | 7 | 83538 | 34654 | 29456328 |
Injection site pain | 72.16 | 13.44 | 5 | 83540 | 32441 | 29458541 |
Septic shock | 71.65 | 13.44 | 358 | 83187 | 62202 | 29428780 |
Hallucination | 71.39 | 13.44 | 19 | 83526 | 44693 | 29446289 |
Metastases to lymph nodes | 70.56 | 13.44 | 71 | 83474 | 3946 | 29487036 |
Asthma | 70.37 | 13.44 | 7 | 83538 | 33842 | 29457140 |
Therapy partial responder | 70.32 | 13.44 | 80 | 83465 | 5119 | 29485863 |
Pneumonia | 70.11 | 13.44 | 574 | 82971 | 319598 | 29171384 |
Joint swelling | 68.80 | 13.44 | 27 | 83518 | 49603 | 29441379 |
Focal nodular hyperplasia | 68.55 | 13.44 | 23 | 83522 | 132 | 29490850 |
Aorto-oesophageal fistula | 68.36 | 13.44 | 18 | 83527 | 35 | 29490947 |
Chronic obstructive pulmonary disease | 68.10 | 13.44 | 16 | 83529 | 40939 | 29450043 |
Colorectal cancer metastatic | 65.76 | 13.44 | 32 | 83513 | 529 | 29490453 |
Device related infection | 65.73 | 13.44 | 140 | 83405 | 15496 | 29475486 |
Necrotising fasciitis | 65.67 | 13.44 | 63 | 83482 | 3302 | 29487680 |
Intravascular haemolysis | 65.42 | 13.44 | 29 | 83516 | 383 | 29490599 |
Disseminated intravascular coagulation | 65.32 | 13.44 | 162 | 83383 | 19818 | 29471164 |
Leukoencephalopathy | 65.10 | 13.44 | 66 | 83479 | 3701 | 29487281 |
Ascites | 64.70 | 13.44 | 239 | 83306 | 36380 | 29454602 |
Dermatitis | 64.45 | 13.44 | 94 | 83451 | 7704 | 29483278 |
Cholangitis | 63.96 | 13.44 | 92 | 83453 | 7445 | 29483537 |
Psoriasis | 63.63 | 13.44 | 8 | 83537 | 32219 | 29458763 |
Dizziness | 62.74 | 13.44 | 299 | 83246 | 189385 | 29301597 |
Confusional state | 62.57 | 13.44 | 171 | 83374 | 127706 | 29363276 |
Blood glucose increased | 61.50 | 13.44 | 46 | 83499 | 58938 | 29432044 |
Influenza | 61.06 | 13.44 | 21 | 83524 | 41860 | 29449122 |
Rheumatoid arthritis | 61.06 | 13.44 | 9 | 83536 | 32143 | 29458839 |
Incorrect dose administered | 60.90 | 13.44 | 10 | 83535 | 32974 | 29458008 |
Cholinergic syndrome | 60.84 | 13.44 | 29 | 83516 | 457 | 29490525 |
Metastases to peritoneum | 60.38 | 13.44 | 43 | 83502 | 1477 | 29489505 |
Feeling abnormal | 60.01 | 13.44 | 40 | 83505 | 54405 | 29436577 |
Administration site extravasation | 59.94 | 13.44 | 29 | 83516 | 473 | 29490509 |
Asthenia | 59.13 | 13.44 | 894 | 82651 | 214356 | 29276626 |
Dry skin | 59.07 | 13.44 | 172 | 83373 | 23135 | 29467847 |
Bradycardia | 58.94 | 13.44 | 59 | 83486 | 65570 | 29425412 |
Therapeutic product effect decreased | 58.90 | 13.44 | 7 | 83538 | 29444 | 29461538 |
Acute coronary syndrome | 58.46 | 13.44 | 116 | 83429 | 12209 | 29478773 |
Muscle spasms | 56.76 | 13.44 | 60 | 83485 | 65022 | 29425960 |
Folliculitis | 56.15 | 13.44 | 62 | 83483 | 3838 | 29487144 |
Agitation | 56.13 | 13.44 | 38 | 83507 | 51266 | 29439716 |
Sinusitis | 55.97 | 13.44 | 14 | 83531 | 34336 | 29456646 |
Conjunctivitis | 55.64 | 13.44 | 89 | 83456 | 7909 | 29483073 |
Venous thrombosis | 55.10 | 13.44 | 55 | 83490 | 3027 | 29487955 |
Coronary artery disease | 55.04 | 13.44 | 28 | 83517 | 44162 | 29446820 |
Wheezing | 53.29 | 13.44 | 14 | 83531 | 33226 | 29457756 |
Small intestinal perforation | 53.22 | 13.44 | 41 | 83504 | 1591 | 29489391 |
Product use issue | 52.51 | 13.44 | 41 | 83504 | 51403 | 29439579 |
Contusion | 51.99 | 13.44 | 12 | 83533 | 31083 | 29459899 |
Tremor | 51.50 | 13.44 | 80 | 83465 | 73458 | 29417524 |
Electrocardiogram QT prolonged | 51.18 | 13.44 | 19 | 83526 | 36118 | 29454864 |
Intestinal perforation | 50.88 | 13.44 | 86 | 83459 | 8000 | 29482982 |
Rectal perforation | 50.30 | 13.44 | 24 | 83521 | 379 | 29490603 |
Memory impairment | 50.28 | 13.44 | 20 | 83525 | 36450 | 29454532 |
Tumour perforation | 50.08 | 13.44 | 21 | 83524 | 240 | 29490742 |
Oesophagitis | 49.24 | 13.44 | 106 | 83439 | 11817 | 29479165 |
Epistaxis | 49.04 | 13.44 | 281 | 83264 | 51423 | 29439559 |
Nasopharyngitis | 48.75 | 13.44 | 58 | 83487 | 59607 | 29431375 |
Stress | 48.71 | 13.44 | 3 | 83542 | 21487 | 29469495 |
Large intestinal obstruction | 48.54 | 13.44 | 36 | 83509 | 1318 | 29489664 |
Disturbance in attention | 48.53 | 13.44 | 3 | 83542 | 21421 | 29469561 |
Mucosal toxicity | 48.45 | 13.44 | 19 | 83526 | 180 | 29490802 |
Hypertransaminasaemia | 47.94 | 13.44 | 55 | 83490 | 3551 | 29487431 |
Fistula | 46.97 | 13.44 | 65 | 83480 | 5074 | 29485908 |
Anastomotic fistula | 46.44 | 13.44 | 14 | 83531 | 53 | 29490929 |
Hypoglycaemia | 46.29 | 13.44 | 41 | 83504 | 48305 | 29442677 |
Incorrect drug administration rate | 46.09 | 13.44 | 33 | 83512 | 1143 | 29489839 |
Pulmonary artery thrombosis | 46.09 | 13.44 | 26 | 83519 | 589 | 29490393 |
Foetal exposure during pregnancy | 45.99 | 13.44 | 19 | 83526 | 33848 | 29457134 |
Hyperbilirubinaemia | 45.59 | 13.44 | 118 | 83427 | 14816 | 29476166 |
Unevaluable event | 45.22 | 13.44 | 14 | 83531 | 29837 | 29461145 |
Musculoskeletal stiffness | 44.78 | 13.44 | 25 | 83520 | 37433 | 29453549 |
Myocardial infarction | 43.75 | 13.44 | 162 | 83383 | 110134 | 29380848 |
Subclavian vein thrombosis | 43.64 | 13.44 | 28 | 83517 | 807 | 29490175 |
Aortic thrombosis | 43.63 | 13.44 | 26 | 83519 | 655 | 29490327 |
Bacterial translocation | 43.53 | 13.44 | 18 | 83527 | 198 | 29490784 |
Dysphonia | 43.32 | 13.44 | 136 | 83409 | 19060 | 29471922 |
Vena cava thrombosis | 43.23 | 13.44 | 30 | 83515 | 988 | 29489994 |
Neutropenic colitis | 43.05 | 13.44 | 43 | 83502 | 2368 | 29488614 |
Malignant ascites | 42.68 | 13.44 | 21 | 83524 | 356 | 29490626 |
Irritability | 42.53 | 13.44 | 6 | 83539 | 22146 | 29468836 |
Injury | 42.16 | 13.44 | 3 | 83542 | 19043 | 29471939 |
Carbohydrate antigen 19-9 increased | 42.02 | 13.44 | 17 | 83528 | 176 | 29490806 |
Duodenal perforation | 41.42 | 13.44 | 31 | 83514 | 1151 | 29489831 |
Treatment noncompliance | 41.20 | 13.44 | 9 | 83536 | 24218 | 29466764 |
Cytomegalovirus infection | 40.77 | 13.44 | 8 | 83537 | 23207 | 29467775 |
Colon cancer recurrent | 40.26 | 13.44 | 14 | 83531 | 91 | 29490891 |
Transdifferentiation of neoplasm | 40.23 | 13.44 | 13 | 83532 | 65 | 29490917 |
Acral peeling skin syndrome | 40.11 | 13.44 | 12 | 83533 | 44 | 29490938 |
Nicotinic acid deficiency | 39.59 | 13.44 | 13 | 83532 | 69 | 29490913 |
Arthritis | 39.24 | 13.44 | 11 | 83534 | 25008 | 29465974 |
Cellulitis | 39.13 | 13.44 | 43 | 83502 | 45797 | 29445185 |
Venoocclusive liver disease | 38.88 | 13.44 | 70 | 83475 | 6847 | 29484135 |
Skin disorder | 38.81 | 13.44 | 95 | 83450 | 11523 | 29479459 |
Anal haemorrhage | 38.79 | 13.44 | 37 | 83508 | 1925 | 29489057 |
Anal erythema | 38.55 | 13.44 | 13 | 83532 | 76 | 29490906 |
Abnormal behaviour | 38.51 | 13.44 | 9 | 83536 | 23118 | 29467864 |
Skin fissures | 37.98 | 13.44 | 51 | 83494 | 3868 | 29487114 |
Intestinal ischaemia | 37.97 | 13.44 | 68 | 83477 | 6624 | 29484358 |
Fluid retention | 37.62 | 13.44 | 10 | 83535 | 23550 | 29467432 |
Anaemia | 37.08 | 13.44 | 784 | 82761 | 200167 | 29290815 |
Drug hypersensitivity | 36.88 | 13.44 | 87 | 83458 | 68319 | 29422663 |
Tumour haemorrhage | 36.63 | 13.44 | 40 | 83505 | 2445 | 29488537 |
Pelvic fluid collection | 35.97 | 13.44 | 13 | 83532 | 96 | 29490886 |
Nodular regenerative hyperplasia | 35.93 | 13.44 | 23 | 83522 | 660 | 29490322 |
Hyperkalaemia | 35.61 | 13.44 | 75 | 83470 | 61317 | 29429665 |
Abdominal discomfort | 35.58 | 13.44 | 50 | 83495 | 47853 | 29443129 |
Balance disorder | 35.44 | 13.44 | 30 | 83515 | 36140 | 29454842 |
Proteus infection | 35.32 | 13.44 | 25 | 83520 | 850 | 29490132 |
Cardiac disorder | 35.19 | 13.44 | 32 | 83513 | 37231 | 29453751 |
Perforation | 35.12 | 13.44 | 15 | 83530 | 180 | 29490802 |
Laryngospasm | 34.80 | 13.44 | 29 | 83516 | 1261 | 29489721 |
Liver abscess | 34.76 | 13.44 | 45 | 83500 | 3293 | 29487689 |
Biliary tract infection | 34.72 | 13.44 | 20 | 83525 | 472 | 29490510 |
Chronic kidney disease | 34.72 | 13.44 | 31 | 83514 | 36385 | 29454597 |
Acute abdomen | 34.64 | 13.44 | 33 | 83512 | 1714 | 29489268 |
Diabetes mellitus | 34.40 | 13.44 | 37 | 83508 | 39794 | 29451188 |
Respiratory arrest | 34.27 | 13.44 | 15 | 83530 | 25818 | 29465164 |
Hypersensitivity | 34.05 | 13.44 | 261 | 83284 | 52642 | 29438340 |
Psychotic disorder | 33.73 | 13.44 | 8 | 83537 | 20346 | 29470636 |
Dysphagia | 33.71 | 13.44 | 268 | 83277 | 54658 | 29436324 |
White blood cell count decreased | 33.69 | 13.44 | 372 | 83173 | 82990 | 29407992 |
Vasospasm | 33.59 | 13.44 | 17 | 83528 | 307 | 29490675 |
Aphthous ulcer | 33.56 | 13.44 | 49 | 83496 | 4019 | 29486963 |
Portal vein thrombosis | 33.51 | 13.44 | 44 | 83501 | 3265 | 29487717 |
Prinzmetal angina | 33.43 | 13.44 | 24 | 83521 | 835 | 29490147 |
Hypophagia | 33.38 | 13.44 | 132 | 83413 | 20740 | 29470242 |
Hypoalbuminaemia | 33.09 | 13.44 | 83 | 83462 | 10222 | 29480760 |
Enterovesical fistula | 33.08 | 13.44 | 21 | 83524 | 594 | 29490388 |
Induration | 33.01 | 13.44 | 24 | 83521 | 852 | 29490130 |
Gait disturbance | 32.98 | 13.44 | 102 | 83443 | 73247 | 29417735 |
Tumour lysis syndrome | 32.84 | 13.44 | 100 | 83445 | 13784 | 29477198 |
Odynophagia | 32.53 | 13.44 | 52 | 83493 | 4618 | 29486364 |
Stoma site haemorrhage | 32.50 | 13.44 | 22 | 83523 | 695 | 29490287 |
Oesophageal stenosis | 32.37 | 13.44 | 30 | 83515 | 1505 | 29489477 |
Cytomegalovirus oesophagitis | 32.30 | 13.44 | 18 | 83527 | 398 | 29490584 |
Hypovolaemic shock | 32.30 | 13.44 | 60 | 83485 | 6012 | 29484970 |
International normalised ratio increased | 32.28 | 13.44 | 47 | 83498 | 44325 | 29446657 |
Xerosis | 32.15 | 13.44 | 19 | 83526 | 471 | 29490511 |
Oral pain | 32.05 | 13.44 | 77 | 83468 | 9230 | 29481752 |
Gastric perforation | 31.90 | 13.44 | 35 | 83510 | 2151 | 29488831 |
Pain | 31.85 | 13.44 | 320 | 83225 | 171112 | 29319870 |
Oesophagobronchial fistula | 31.28 | 13.44 | 13 | 83532 | 145 | 29490837 |
Type II hypersensitivity | 30.97 | 13.44 | 9 | 83536 | 29 | 29490953 |
Stress cardiomyopathy | 30.93 | 13.44 | 30 | 83515 | 1594 | 29489388 |
Jugular vein thrombosis | 30.76 | 13.44 | 28 | 83517 | 1372 | 29489610 |
Blood pressure fluctuation | 30.73 | 13.44 | 9 | 83536 | 19885 | 29471097 |
Enterocolitis | 30.72 | 13.44 | 62 | 83483 | 6604 | 29484378 |
Recall phenomenon | 30.61 | 13.44 | 19 | 83526 | 516 | 29490466 |
Hepatic lesion | 30.54 | 13.44 | 41 | 83504 | 3109 | 29487873 |
Embolism | 30.44 | 13.44 | 63 | 83482 | 6833 | 29484149 |
Cachexia | 30.40 | 13.44 | 60 | 83485 | 6289 | 29484693 |
Adverse drug reaction | 30.23 | 13.44 | 15 | 83530 | 24005 | 29466977 |
Catheter site thrombosis | 30.08 | 13.44 | 9 | 83536 | 33 | 29490949 |
Bronchitis | 29.93 | 13.44 | 36 | 83509 | 36832 | 29454150 |
Influenza like illness | 29.73 | 13.44 | 16 | 83529 | 24454 | 29466528 |
Blood creatine phosphokinase increased | 29.62 | 13.44 | 43 | 83502 | 40601 | 29450381 |
Peritoneal neoplasm | 29.47 | 13.44 | 9 | 83536 | 36 | 29490946 |
Right ventricular ejection fraction decreased | 29.47 | 13.44 | 9 | 83536 | 36 | 29490946 |
Pulmonary fibrosis | 29.46 | 13.44 | 104 | 83441 | 15478 | 29475504 |
Condition aggravated | 29.32 | 13.44 | 268 | 83277 | 146027 | 29344955 |
Prostate cancer | 29.15 | 13.44 | 18 | 83527 | 25509 | 29465473 |
Sciatic nerve palsy | 29.08 | 13.44 | 9 | 83536 | 38 | 29490944 |
Colitis microscopic | 28.86 | 13.44 | 30 | 83515 | 1733 | 29489249 |
Pneumonitis chemical | 28.70 | 13.44 | 12 | 83533 | 136 | 29490846 |
Palmar erythema | 28.68 | 13.44 | 14 | 83531 | 233 | 29490749 |
Renal disorder | 28.60 | 13.44 | 14 | 83531 | 22581 | 29468401 |
Sedation | 28.53 | 13.44 | 7 | 83538 | 17398 | 29473584 |
Subdural haematoma | 28.52 | 13.44 | 8 | 83537 | 18185 | 29472797 |
Vocal cord paralysis | 28.50 | 13.44 | 22 | 83523 | 856 | 29490126 |
Perforation bile duct | 28.47 | 13.44 | 8 | 83537 | 22 | 29490960 |
Colitis | 28.43 | 13.44 | 168 | 83377 | 31080 | 29459902 |
Hypertension | 28.39 | 13.44 | 475 | 83070 | 116139 | 29374843 |
Liver function test abnormal | 28.31 | 13.44 | 24 | 83521 | 28894 | 29462088 |
Acne | 28.29 | 13.44 | 73 | 83472 | 9147 | 29481835 |
Pneumonitis | 28.29 | 13.44 | 155 | 83390 | 27889 | 29463093 |
Dihydropyrimidine dehydrogenase deficiency | 28.25 | 13.44 | 10 | 83535 | 69 | 29490913 |
Neutropenic sepsis | 28.24 | 13.44 | 85 | 83460 | 11642 | 29479340 |
Blood pressure increased | 28.21 | 13.44 | 110 | 83435 | 73693 | 29417289 |
Nephrotic syndrome | 28.15 | 13.44 | 58 | 83487 | 6270 | 29484712 |
Drug level increased | 28.11 | 13.44 | 9 | 83536 | 18778 | 29472204 |
Venous thrombosis limb | 28.01 | 13.44 | 29 | 83516 | 1667 | 29489315 |
Tumour marker increased | 27.83 | 13.44 | 18 | 83527 | 526 | 29490456 |
Mouth ulceration | 27.77 | 13.44 | 78 | 83467 | 10277 | 29480705 |
Device related thrombosis | 27.42 | 13.44 | 22 | 83523 | 906 | 29490076 |
Colon cancer metastatic | 27.38 | 13.44 | 27 | 83518 | 1464 | 29489518 |
Head injury | 27.29 | 13.44 | 6 | 83539 | 16075 | 29474907 |
Gastrointestinal necrosis | 27.28 | 13.44 | 38 | 83507 | 2984 | 29487998 |
Erythema | 27.24 | 13.44 | 330 | 83215 | 75276 | 29415706 |
Gastrointestinal ischaemia | 27.10 | 13.44 | 12 | 83533 | 158 | 29490824 |
Haematoma | 27.02 | 13.44 | 16 | 83529 | 23196 | 29467786 |
Cough | 26.78 | 13.44 | 229 | 83316 | 126498 | 29364484 |
Subacute cutaneous lupus erythematosus | 26.75 | 13.44 | 21 | 83524 | 838 | 29490144 |
Nail toxicity | 26.60 | 13.44 | 8 | 83537 | 30 | 29490952 |
Gastrointestinal anastomotic leak | 26.35 | 13.44 | 15 | 83530 | 346 | 29490636 |
Dyspnoea | 26.20 | 13.44 | 713 | 82832 | 326019 | 29164963 |
Eosinophilia | 26.19 | 13.44 | 15 | 83530 | 22146 | 29468836 |
Enterocutaneous fistula | 26.18 | 13.44 | 20 | 83525 | 766 | 29490216 |
Emotional distress | 26.13 | 13.44 | 4 | 83541 | 13891 | 29477091 |
Abdominal pain lower | 26.10 | 13.44 | 68 | 83477 | 8570 | 29482412 |
Cerebrovascular accident | 26.09 | 13.44 | 120 | 83425 | 76791 | 29414191 |
Nephrolithiasis | 26.08 | 13.44 | 20 | 83525 | 25314 | 29465668 |
Urticaria | 26.02 | 13.44 | 74 | 83471 | 54586 | 29436396 |
PIK3CA-activated mutation | 25.95 | 13.44 | 10 | 83535 | 90 | 29490892 |
Left ventricular dysfunction | 25.80 | 13.44 | 69 | 83476 | 8833 | 29482149 |
Sepsis | 25.73 | 13.44 | 555 | 82990 | 142127 | 29348855 |
Evans syndrome | 25.48 | 13.44 | 13 | 83532 | 239 | 29490743 |
Sleep apnoea syndrome | 25.34 | 13.44 | 9 | 83536 | 17590 | 29473392 |
Proctalgia | 25.20 | 13.44 | 44 | 83501 | 4201 | 29486781 |
Cell-mediated cytotoxicity | 25.09 | 13.44 | 8 | 83537 | 38 | 29490944 |
Anaemia of malignant disease | 25.06 | 13.44 | 15 | 83530 | 381 | 29490601 |
Deep vein thrombosis | 24.97 | 13.44 | 260 | 83285 | 57139 | 29433843 |
Pulmonary oedema | 24.95 | 13.44 | 52 | 83493 | 42683 | 29448299 |
Toxic epidermal necrolysis | 24.94 | 13.44 | 10 | 83535 | 18143 | 29472839 |
Prothrombin level decreased | 24.91 | 13.44 | 22 | 83523 | 1036 | 29489946 |
Drug ineffective for unapproved indication | 24.74 | 13.44 | 5 | 83540 | 14209 | 29476773 |
Carbohydrate antigen 15-3 increased | 24.61 | 13.44 | 9 | 83536 | 69 | 29490913 |
Nail disorder | 24.55 | 13.44 | 28 | 83517 | 1796 | 29489186 |
COVID-19 | 24.42 | 13.44 | 40 | 83505 | 35974 | 29455008 |
Proctitis | 24.34 | 13.44 | 30 | 83515 | 2089 | 29488893 |
Loss of personal independence in daily activities | 23.84 | 13.44 | 22 | 83523 | 25418 | 29465564 |
Trichomegaly | 23.76 | 13.44 | 7 | 83538 | 24 | 29490958 |
Stoma site pain | 23.71 | 13.44 | 16 | 83529 | 503 | 29490479 |
Renal salt-wasting syndrome | 23.44 | 13.44 | 11 | 83534 | 167 | 29490815 |
Conjunctival filtering bleb leak | 23.38 | 13.44 | 6 | 83539 | 10 | 29490972 |
Colitis ulcerative | 23.28 | 13.44 | 4 | 83541 | 12765 | 29478217 |
Koebner phenomenon | 23.27 | 13.44 | 8 | 83537 | 50 | 29490932 |
Off label use | 23.26 | 13.44 | 1055 | 82490 | 299745 | 29191237 |
Varices oesophageal | 23.25 | 13.44 | 36 | 83509 | 3110 | 29487872 |
Dysaesthesia pharynx | 23.01 | 13.44 | 8 | 83537 | 52 | 29490930 |
Hypercreatininaemia | 22.73 | 13.44 | 15 | 83530 | 454 | 29490528 |
Pachymeningitis | 22.70 | 13.44 | 9 | 83536 | 88 | 29490894 |
Herpes zoster | 22.68 | 13.44 | 31 | 83514 | 30021 | 29460961 |
Fistula of small intestine | 22.53 | 13.44 | 14 | 83531 | 381 | 29490601 |
Myoclonus | 22.52 | 13.44 | 5 | 83540 | 13304 | 29477678 |
Rectal tenesmus | 22.49 | 13.44 | 17 | 83528 | 641 | 29490341 |
Mobility decreased | 22.20 | 13.44 | 24 | 83521 | 25756 | 29465226 |
Gout | 22.14 | 13.44 | 10 | 83535 | 16901 | 29474081 |
Rectal cancer metastatic | 22.12 | 13.44 | 11 | 83534 | 191 | 29490791 |
Contraindicated product administered | 22.11 | 13.44 | 12 | 83533 | 18254 | 29472728 |
Perineal disorder | 22.03 | 13.44 | 8 | 83537 | 60 | 29490922 |
Hypervolaemia | 22.01 | 13.44 | 11 | 83534 | 17534 | 29473448 |
Balanoposthitis | 21.94 | 13.44 | 20 | 83525 | 982 | 29490000 |
Haemoglobinuria | 21.88 | 13.44 | 16 | 83529 | 573 | 29490409 |
Abdominal abscess | 21.88 | 13.44 | 39 | 83506 | 3785 | 29487197 |
Interventricular septum rupture | 21.76 | 13.44 | 6 | 83539 | 15 | 29490967 |
Adverse event | 21.71 | 13.44 | 8 | 83537 | 15283 | 29475699 |
Hepatitis B | 21.70 | 13.44 | 48 | 83497 | 5449 | 29485533 |
Heart rate decreased | 21.67 | 13.44 | 23 | 83522 | 24889 | 29466093 |
Blood glucose decreased | 21.53 | 13.44 | 4 | 83541 | 12065 | 29478917 |
Cerebral vasoconstriction | 21.42 | 13.44 | 11 | 83534 | 205 | 29490777 |
Lower respiratory tract infection | 21.38 | 13.44 | 26 | 83519 | 26476 | 29464506 |
Febrile bone marrow aplasia | 21.33 | 13.44 | 57 | 83488 | 7294 | 29483688 |
Delirium | 21.31 | 13.44 | 50 | 83495 | 39347 | 29451635 |
Hepatectomy | 21.26 | 13.44 | 8 | 83537 | 67 | 29490915 |
Ectropion | 21.26 | 13.44 | 8 | 83537 | 67 | 29490915 |
Splenomegaly | 21.24 | 13.44 | 84 | 83461 | 13195 | 29477787 |
Drug intolerance | 21.23 | 13.44 | 68 | 83477 | 48311 | 29442671 |
Wrong technique in product usage process | 21.22 | 13.44 | 35 | 83510 | 31393 | 29459589 |
Respiratory depression | 21.10 | 13.44 | 6 | 83539 | 13517 | 29477465 |
Underdose | 21.03 | 13.44 | 4 | 83541 | 11865 | 29479117 |
Unresponsive to stimuli | 20.97 | 13.44 | 24 | 83521 | 25102 | 29465880 |
Pseudocirrhosis | 20.97 | 13.44 | 6 | 83539 | 18 | 29490964 |
Toxic erythema of chemotherapy | 20.96 | 13.44 | 8 | 83537 | 70 | 29490912 |
Pneumoperitoneum | 20.92 | 13.44 | 24 | 83521 | 1549 | 29489433 |
Anger | 20.79 | 13.44 | 3 | 83542 | 10887 | 29480095 |
Blood cholesterol increased | 20.77 | 13.44 | 9 | 83536 | 15586 | 29475396 |
Perioral dermatitis | 20.71 | 13.44 | 9 | 83536 | 113 | 29490869 |
Hepatic atrophy | 20.62 | 13.44 | 10 | 83535 | 164 | 29490818 |
Swelling | 20.54 | 13.44 | 43 | 83502 | 35240 | 29455742 |
Clostridial infection | 20.51 | 13.44 | 35 | 83510 | 3280 | 29487702 |
Diffuse alveolar damage | 20.43 | 13.44 | 27 | 83518 | 2016 | 29488966 |
NPM1 gene mutation | 20.43 | 13.44 | 9 | 83536 | 117 | 29490865 |
Oesophageal perforation | 20.42 | 13.44 | 17 | 83528 | 738 | 29490244 |
Anorectal discomfort | 20.36 | 13.44 | 24 | 83521 | 1595 | 29489387 |
Vision blurred | 20.16 | 13.44 | 53 | 83492 | 40123 | 29450859 |
Pulmonary infarction | 20.15 | 13.44 | 20 | 83525 | 1093 | 29489889 |
Product prescribing error | 20.08 | 13.44 | 13 | 83532 | 17963 | 29473019 |
Thrombotic thrombocytopenic purpura | 20.04 | 13.44 | 34 | 83511 | 3172 | 29487810 |
Soft tissue disorder | 20.01 | 13.44 | 16 | 83529 | 656 | 29490326 |
Premature baby | 19.99 | 13.44 | 12 | 83533 | 17268 | 29473714 |
Seizure | 19.78 | 13.44 | 168 | 83377 | 92955 | 29398027 |
Protein urine | 19.53 | 13.44 | 17 | 83528 | 785 | 29490197 |
Perihepatic abscess | 19.51 | 13.44 | 8 | 83537 | 86 | 29490896 |
Tubulointerstitial nephritis | 19.38 | 13.44 | 13 | 83532 | 17630 | 29473352 |
Accidental overdose | 19.27 | 13.44 | 13 | 83532 | 17580 | 29473402 |
Refeeding syndrome | 19.26 | 13.44 | 6 | 83539 | 26 | 29490956 |
Microgenia | 19.24 | 13.44 | 5 | 83540 | 9 | 29490973 |
Dyskinesia | 19.21 | 13.44 | 17 | 83528 | 20044 | 29470938 |
Anal fissure | 19.19 | 13.44 | 31 | 83514 | 2777 | 29488205 |
Device related sepsis | 19.07 | 13.44 | 29 | 83516 | 2466 | 29488516 |
Pelvic venous thrombosis | 19.06 | 13.44 | 14 | 83531 | 505 | 29490477 |
Osteoarthritis | 19.01 | 13.44 | 14 | 83531 | 18089 | 29472893 |
Necrotising oesophagitis | 18.99 | 13.44 | 14 | 83531 | 508 | 29490474 |
Ischiorectal hernia | 18.90 | 13.44 | 5 | 83540 | 10 | 29490972 |
Paraesthesia oral | 18.87 | 13.44 | 35 | 83510 | 3502 | 29487480 |
Prostatic specific antigen increased | 18.83 | 13.44 | 6 | 83539 | 12558 | 29478424 |
Erectile dysfunction | 18.82 | 13.44 | 14 | 83531 | 17995 | 29472987 |
Dysgeusia | 18.78 | 13.44 | 119 | 83426 | 22555 | 29468427 |
Enterocolitis haemorrhagic | 18.68 | 13.44 | 17 | 83528 | 833 | 29490149 |
Guillain-Barre syndrome | 18.67 | 13.44 | 43 | 83502 | 5015 | 29485967 |
Arthropathy | 18.63 | 13.44 | 20 | 83525 | 21534 | 29469448 |
Lymph node abscess | 18.58 | 13.44 | 5 | 83540 | 11 | 29490971 |
Intestinal strangulation | 18.57 | 13.44 | 6 | 83539 | 30 | 29490952 |
Peritoneal haematoma | 18.57 | 13.44 | 7 | 83538 | 59 | 29490923 |
Cerebral haemorrhage | 18.55 | 13.44 | 38 | 83507 | 31388 | 29459594 |
Jaundice | 18.54 | 13.44 | 144 | 83401 | 29152 | 29461830 |
Superior vena cava syndrome | 18.54 | 13.44 | 14 | 83531 | 527 | 29490455 |
Duodenal ulcer perforation | 18.41 | 13.44 | 22 | 83523 | 1484 | 29489498 |
Heart rate irregular | 18.39 | 13.44 | 7 | 83538 | 13110 | 29477872 |
Metastasis | 18.38 | 13.44 | 34 | 83511 | 3395 | 29487587 |
Portal vein embolisation | 18.28 | 13.44 | 5 | 83540 | 12 | 29490970 |
Accidental exposure to product | 18.27 | 13.44 | 4 | 83541 | 10749 | 29480233 |
Retroperitoneal abscess | 18.22 | 13.44 | 9 | 83536 | 154 | 29490828 |
Acute respiratory distress syndrome | 18.16 | 13.44 | 119 | 83426 | 22816 | 29468166 |
Tetany | 18.10 | 13.44 | 15 | 83530 | 647 | 29490335 |
Muscular weakness | 18.09 | 13.44 | 102 | 83443 | 61950 | 29429032 |
Lymphoma | 18.09 | 13.44 | 3 | 83542 | 9825 | 29481157 |
Primitive neuroectodermal tumour | 18.07 | 13.44 | 7 | 83538 | 64 | 29490918 |
Eyelash changes | 17.99 | 13.44 | 5 | 83540 | 13 | 29490969 |
Colony stimulating factor therapy | 17.96 | 13.44 | 9 | 83536 | 159 | 29490823 |
Mental disorder | 17.91 | 13.44 | 7 | 83538 | 12898 | 29478084 |
Bronchiolitis obliterans syndrome | 17.86 | 13.44 | 9 | 83536 | 161 | 29490821 |
Diabetes mellitus inadequate control | 17.83 | 13.44 | 6 | 83539 | 12128 | 29478854 |
Inappropriate schedule of product administration | 17.82 | 13.44 | 65 | 83480 | 44407 | 29446575 |
Intentional product use issue | 17.77 | 13.44 | 61 | 83484 | 42437 | 29448545 |
Oesophageal haemorrhage | 17.77 | 13.44 | 19 | 83526 | 1134 | 29489848 |
Myopathy | 17.73 | 13.44 | 4 | 83541 | 10529 | 29480453 |
Pancreatitis | 17.72 | 13.44 | 45 | 83500 | 34469 | 29456513 |
Performance status decreased | 17.58 | 13.44 | 35 | 83510 | 3692 | 29487290 |
Wound dehiscence | 17.56 | 13.44 | 31 | 83514 | 2986 | 29487996 |
Gastrointestinal stoma complication | 17.51 | 13.44 | 19 | 83526 | 1153 | 29489829 |
Visceral venous thrombosis | 17.47 | 13.44 | 5 | 83540 | 15 | 29490967 |
Injection site reaction | 17.39 | 13.44 | 5 | 83540 | 11183 | 29479799 |
Lymphangiosis carcinomatosa | 17.37 | 13.44 | 16 | 83529 | 796 | 29490186 |
Neck pain | 17.35 | 13.44 | 21 | 83524 | 21426 | 29469556 |
B-cell small lymphocytic lymphoma | 17.32 | 13.44 | 8 | 83537 | 117 | 29490865 |
Hypersplenism | 17.27 | 13.44 | 11 | 83534 | 313 | 29490669 |
Haemorrhagic tumour necrosis | 17.26 | 13.44 | 4 | 83541 | 3 | 29490979 |
K-ras gene mutation | 17.23 | 13.44 | 5 | 83540 | 16 | 29490966 |
Injection site erythema | 17.14 | 13.44 | 9 | 83536 | 13947 | 29477035 |
Nail ridging | 17.13 | 13.44 | 6 | 83539 | 40 | 29490942 |
Fixed eruption | 17.12 | 13.44 | 19 | 83526 | 1183 | 29489799 |
Stevens-Johnson syndrome | 17.01 | 13.44 | 13 | 83532 | 16484 | 29474498 |
Angioedema | 16.86 | 13.44 | 41 | 83504 | 31874 | 29459108 |
Monocytopenia | 16.85 | 13.44 | 7 | 83538 | 78 | 29490904 |
Acute cutaneous lupus erythematosus | 16.77 | 13.44 | 7 | 83538 | 79 | 29490903 |
Acute motor-sensory axonal neuropathy | 16.73 | 13.44 | 8 | 83537 | 127 | 29490855 |
Intrahepatic portal hepatic venous fistula | 16.73 | 13.44 | 4 | 83541 | 4 | 29490978 |
Hepatic enzyme increased | 16.64 | 13.44 | 45 | 83500 | 33754 | 29457228 |
Rectal ulcer | 16.64 | 13.44 | 16 | 83529 | 841 | 29490141 |
Osteomyelitis | 16.60 | 13.44 | 9 | 83536 | 13700 | 29477282 |
Product use in unapproved indication | 16.59 | 13.44 | 161 | 83384 | 86714 | 29404268 |
Neoplasm recurrence | 16.58 | 13.44 | 24 | 83521 | 1953 | 29489029 |
Product administration error | 16.46 | 13.44 | 10 | 83535 | 14300 | 29476682 |
Swollen tongue | 16.46 | 13.44 | 7 | 83538 | 12259 | 29478723 |
Hepatitis B surface antigen positive | 16.40 | 13.44 | 8 | 83537 | 133 | 29490849 |
VIth nerve disorder | 16.37 | 13.44 | 5 | 83540 | 20 | 29490962 |
Pulmonary toxicity | 16.35 | 13.44 | 40 | 83505 | 4850 | 29486132 |
Metastases to pelvis | 16.33 | 13.44 | 10 | 83535 | 265 | 29490717 |
Catheter site extravasation | 16.31 | 13.44 | 7 | 83538 | 85 | 29490897 |
Bacteraemia | 16.31 | 13.44 | 90 | 83455 | 16233 | 29474749 |
Radiation mucositis | 16.29 | 13.44 | 8 | 83537 | 135 | 29490847 |
Blood triglycerides increased | 16.17 | 13.44 | 8 | 83537 | 12826 | 29478156 |
Pancreatic neuroendocrine tumour metastatic | 16.17 | 13.44 | 7 | 83538 | 87 | 29490895 |
Treatment failure | 16.15 | 13.44 | 52 | 83493 | 36887 | 29454095 |
Toxic leukoencephalopathy | 16.13 | 13.44 | 10 | 83535 | 271 | 29490711 |
Laryngeal oedema | 16.06 | 13.44 | 30 | 83515 | 3018 | 29487964 |
Bacterial colitis | 15.97 | 13.44 | 6 | 83539 | 50 | 29490932 |
Bile duct stenosis | 15.94 | 13.44 | 18 | 83527 | 1142 | 29489840 |
Fatigue | 15.92 | 13.44 | 1068 | 82477 | 315753 | 29175229 |
Rib fracture | 15.92 | 13.44 | 8 | 83537 | 12710 | 29478272 |
Visual impairment | 15.83 | 13.44 | 38 | 83507 | 29670 | 29461312 |
Colorectal cancer recurrent | 15.81 | 13.44 | 5 | 83540 | 23 | 29490959 |
Product quality issue | 15.79 | 13.44 | 13 | 83532 | 15882 | 29475100 |
Hepatic failure | 15.77 | 13.44 | 147 | 83398 | 31365 | 29459617 |
Radiation skin injury | 15.73 | 13.44 | 14 | 83531 | 666 | 29490316 |
Anaphylactic shock | 15.73 | 13.44 | 77 | 83468 | 13259 | 29477723 |
Hyperlipidaemia | 15.64 | 13.44 | 8 | 83537 | 12582 | 29478400 |
Laboratory test abnormal | 15.58 | 13.44 | 17 | 83528 | 18168 | 29472814 |
Heart rate increased | 15.54 | 13.44 | 57 | 83488 | 38881 | 29452101 |
Aplasia | 15.50 | 13.44 | 35 | 83510 | 4028 | 29486954 |
Electromyogram abnormal | 15.47 | 13.44 | 6 | 83539 | 55 | 29490927 |
Radiation interaction | 15.47 | 13.44 | 5 | 83540 | 25 | 29490957 |
Respiratory alkalosis | 15.46 | 13.44 | 20 | 83525 | 1463 | 29489519 |
Therapy cessation | 15.43 | 13.44 | 11 | 83534 | 14451 | 29476531 |
Localised infection | 15.42 | 13.44 | 10 | 83535 | 13806 | 29477176 |
Hyperthermia | 15.36 | 13.44 | 60 | 83485 | 9370 | 29481612 |
Swelling face | 15.35 | 13.44 | 21 | 83524 | 20329 | 29470653 |
Gastrointestinal obstruction | 15.31 | 13.44 | 14 | 83531 | 690 | 29490292 |
Tracheal stenosis | 15.30 | 13.44 | 8 | 83537 | 155 | 29490827 |
Tooth disorder | 15.30 | 13.44 | 4 | 83541 | 9525 | 29481457 |
Pulmonary hypertension | 15.28 | 13.44 | 18 | 83527 | 18590 | 29472392 |
Chimerism | 15.27 | 13.44 | 9 | 83536 | 222 | 29490760 |
Sarcoidosis | 15.20 | 13.44 | 27 | 83518 | 2613 | 29488369 |
Rectal abscess | 15.20 | 13.44 | 16 | 83529 | 938 | 29490044 |
Road traffic accident | 15.13 | 13.44 | 13 | 83532 | 15548 | 29475434 |
Therapeutic response unexpected | 15.12 | 13.44 | 3 | 83542 | 8635 | 29482347 |
Pneumoretroperitoneum | 15.10 | 13.44 | 6 | 83539 | 59 | 29490923 |
Cardiomyopathy | 15.09 | 13.44 | 82 | 83463 | 14705 | 29476277 |
Neurosarcoidosis | 14.98 | 13.44 | 8 | 83537 | 162 | 29490820 |
Eye pain | 14.96 | 13.44 | 7 | 83538 | 11588 | 29479394 |
Limb injury | 14.88 | 13.44 | 4 | 83541 | 9351 | 29481631 |
Periportal sinus dilatation | 14.86 | 13.44 | 5 | 83540 | 29 | 29490953 |
Intestinal mucosal hypertrophy | 14.84 | 13.44 | 6 | 83539 | 62 | 29490920 |
Vestibular neuronitis | 14.81 | 13.44 | 8 | 83537 | 166 | 29490816 |
Nasal congestion | 14.73 | 13.44 | 19 | 83526 | 18860 | 29472122 |
Rectal stenosis | 14.72 | 13.44 | 8 | 83537 | 168 | 29490814 |
Klebsiella infection | 14.72 | 13.44 | 50 | 83495 | 7299 | 29483683 |
Colorectal cancer | 14.70 | 13.44 | 22 | 83523 | 1845 | 29489137 |
Oedema peripheral | 14.69 | 13.44 | 205 | 83340 | 103352 | 29387630 |
Hypersomnia | 14.65 | 13.44 | 6 | 83539 | 10748 | 29480234 |
Herpes simplex meningomyelitis | 14.62 | 13.44 | 3 | 83542 | 0 | 29490982 |
Tumour fistulisation | 14.51 | 13.44 | 4 | 83541 | 10 | 29490972 |
Faeces discoloured | 14.45 | 13.44 | 10 | 83535 | 13341 | 29477641 |
Soft tissue swelling | 14.44 | 13.44 | 10 | 83535 | 328 | 29490654 |
Product substitution issue | 14.44 | 13.44 | 4 | 83541 | 9168 | 29481814 |
Hernia | 14.42 | 13.44 | 3 | 83542 | 8355 | 29482627 |
Non-cirrhotic portal hypertension | 14.42 | 13.44 | 9 | 83536 | 247 | 29490735 |
Productive cough | 14.37 | 13.44 | 43 | 83502 | 31216 | 29459766 |
Rectal haemorrhage | 14.32 | 13.44 | 155 | 83390 | 34394 | 29456588 |
Pneumomediastinum | 14.27 | 13.44 | 21 | 83524 | 1735 | 29489247 |
Aspergillus infection | 14.26 | 13.44 | 6 | 83539 | 10575 | 29480407 |
Astringent therapy | 14.23 | 13.44 | 4 | 83541 | 11 | 29490971 |
Stress ulcer | 14.12 | 13.44 | 6 | 83539 | 71 | 29490911 |
Suture rupture | 14.10 | 13.44 | 10 | 83535 | 341 | 29490641 |
Rectal adenocarcinoma | 14.09 | 13.44 | 14 | 83531 | 766 | 29490216 |
Peritoneal disorder | 14.04 | 13.44 | 9 | 83536 | 259 | 29490723 |
Adenocarcinoma | 14.03 | 13.44 | 20 | 83525 | 1605 | 29489377 |
Chemotherapy | 14.01 | 13.44 | 12 | 83533 | 542 | 29490440 |
Peritoneal adhesions | 14.00 | 13.44 | 7 | 83538 | 123 | 29490859 |
Axillary vein thrombosis | 14.00 | 13.44 | 8 | 83537 | 186 | 29490796 |
Metapneumovirus bronchiolitis | 13.98 | 13.44 | 4 | 83541 | 12 | 29490970 |
Temperature difference of extremities | 13.98 | 13.44 | 4 | 83541 | 12 | 29490970 |
Cytokine release syndrome | 13.97 | 13.44 | 10 | 83535 | 13109 | 29477873 |
Gastrointestinal inflammation | 13.89 | 13.44 | 28 | 83517 | 2980 | 29488002 |
Night sweats | 13.89 | 13.44 | 13 | 83532 | 14919 | 29476063 |
Duodenal stenosis | 13.84 | 13.44 | 8 | 83537 | 190 | 29490792 |
Osteoradionecrosis | 13.83 | 13.44 | 6 | 83539 | 75 | 29490907 |
Amnesia | 13.69 | 13.44 | 27 | 83518 | 22616 | 29468366 |
Viral infection | 13.65 | 13.44 | 13 | 83532 | 14797 | 29476185 |
Full blood count decreased | 13.64 | 13.44 | 15 | 83530 | 15977 | 29475005 |
Portal shunt | 13.60 | 13.44 | 5 | 83540 | 39 | 29490943 |
Blister | 13.59 | 13.44 | 22 | 83523 | 19884 | 29471098 |
Hepatic pain | 13.52 | 13.44 | 17 | 83528 | 1208 | 29489774 |
Encapsulating peritoneal sclerosis | 13.52 | 13.44 | 12 | 83533 | 569 | 29490413 |
Oesophageal varices haemorrhage | 13.50 | 13.44 | 26 | 83519 | 2676 | 29488306 |
Movement disorder | 13.49 | 13.44 | 6 | 83539 | 10231 | 29480751 |
Oral dysaesthesia | 13.48 | 13.44 | 6 | 83539 | 80 | 29490902 |
Bacteriuria | 13.47 | 13.44 | 9 | 83536 | 278 | 29490704 |
MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
---|---|---|---|---|---|---|
Neutropenia | 2707.94 | 12.49 | 2908 | 133101 | 236716 | 64126007 |
Neuropathy peripheral | 1733.17 | 12.49 | 1650 | 134359 | 115875 | 64246848 |
Diarrhoea | 1506.44 | 12.49 | 4100 | 131909 | 718604 | 63644119 |
Mucosal inflammation | 1432.19 | 12.49 | 1130 | 134879 | 61454 | 64301269 |
Dermatitis acneiform | 1263.57 | 12.49 | 523 | 135486 | 7920 | 64354803 |
Disease progression | 1125.18 | 12.49 | 1438 | 134571 | 140242 | 64222481 |
Thrombocytopenia | 952.28 | 12.49 | 1697 | 134312 | 222104 | 64140619 |
Palmar-plantar erythrodysaesthesia syndrome | 912.32 | 12.49 | 633 | 135376 | 28186 | 64334537 |
Febrile neutropenia | 836.76 | 12.49 | 1453 | 134556 | 186204 | 64176519 |
Skin toxicity | 831.84 | 12.49 | 362 | 135647 | 6240 | 64356483 |
Leukopenia | 753.75 | 12.49 | 996 | 135013 | 100246 | 64262477 |
Neurotoxicity | 723.20 | 12.49 | 539 | 135470 | 26865 | 64335858 |
Stomatitis | 715.82 | 12.49 | 1012 | 134997 | 108593 | 64254130 |
Arteriospasm coronary | 628.28 | 12.49 | 281 | 135728 | 5184 | 64357539 |
Metastases to liver | 563.69 | 12.49 | 440 | 135569 | 23501 | 64339222 |
Paronychia | 534.14 | 12.49 | 265 | 135744 | 6227 | 64356496 |
Interstitial lung disease | 497.89 | 12.49 | 804 | 135205 | 96928 | 64265795 |
Neoplasm progression | 495.12 | 12.49 | 517 | 135492 | 40447 | 64322276 |
Bone marrow failure | 485.06 | 12.49 | 551 | 135458 | 47401 | 64315322 |
Completed suicide | 437.53 | 12.49 | 7 | 136002 | 224407 | 64138316 |
Vomiting | 428.77 | 12.49 | 2288 | 133721 | 548829 | 63813894 |
Decreased appetite | 419.69 | 12.49 | 1425 | 134584 | 279864 | 64082859 |
Drug ineffective | 415.80 | 12.49 | 711 | 135298 | 839536 | 63523187 |
Metastases to lung | 406.59 | 12.49 | 302 | 135707 | 14962 | 64347761 |
Gastrointestinal toxicity | 399.00 | 12.49 | 204 | 135805 | 5118 | 64357605 |
Peripheral sensory neuropathy | 398.14 | 12.49 | 266 | 135743 | 11112 | 64351611 |
Malignant neoplasm progression | 398.11 | 12.49 | 791 | 135218 | 112080 | 64250643 |
Arthralgia | 389.53 | 12.49 | 225 | 135784 | 442035 | 63920688 |
Nausea | 385.32 | 12.49 | 2899 | 133110 | 782901 | 63579822 |
Polyneuropathy | 358.26 | 12.49 | 313 | 135696 | 19581 | 64343142 |
Hyperammonaemia | 354.89 | 12.49 | 235 | 135774 | 9669 | 64353054 |
Cardiotoxicity | 351.83 | 12.49 | 237 | 135772 | 10037 | 64352686 |
Proteinuria | 336.92 | 12.49 | 351 | 135658 | 27372 | 64335351 |
Neutrophil count decreased | 335.78 | 12.49 | 592 | 135417 | 76604 | 64286119 |
Rheumatoid arthritis | 305.01 | 12.49 | 9 | 136000 | 164285 | 64198438 |
Product dose omission issue | 294.99 | 12.49 | 33 | 135976 | 194714 | 64168009 |
Joint swelling | 285.78 | 12.49 | 54 | 135955 | 215328 | 64147395 |
General physical health deterioration | 275.44 | 12.49 | 1002 | 135007 | 203423 | 64159300 |
Headache | 266.60 | 12.49 | 442 | 135567 | 529025 | 63833698 |
Gastrointestinal perforation | 260.52 | 12.49 | 155 | 135854 | 5269 | 64357454 |
Fall | 259.88 | 12.49 | 298 | 135711 | 416528 | 63946195 |
Haematotoxicity | 256.87 | 12.49 | 215 | 135794 | 12681 | 64350042 |
Hypomagnesaemia | 255.37 | 12.49 | 353 | 135656 | 37023 | 64325700 |
Myelosuppression | 254.87 | 12.49 | 282 | 135727 | 23548 | 64339175 |
Drug abuse | 250.37 | 12.49 | 6 | 136003 | 132368 | 64230355 |
Hyperammonaemic encephalopathy | 243.26 | 12.49 | 134 | 135875 | 3924 | 64358799 |
Weight increased | 237.48 | 12.49 | 77 | 135932 | 213271 | 64149452 |
Pyrexia | 233.83 | 12.49 | 1990 | 134019 | 556654 | 63806069 |
Dehydration | 227.05 | 12.49 | 982 | 135027 | 215781 | 64146942 |
Enteritis | 223.46 | 12.49 | 193 | 135816 | 11884 | 64350839 |
Portal hypertension | 221.44 | 12.49 | 147 | 135862 | 6072 | 64356651 |
Drug interaction | 221.15 | 12.49 | 263 | 135746 | 361820 | 64000903 |
Paraesthesia | 213.89 | 12.49 | 697 | 135312 | 133825 | 64228898 |
Acute myeloid leukaemia | 209.94 | 12.49 | 274 | 135735 | 27189 | 64335534 |
Sinusitis | 205.85 | 12.49 | 31 | 135978 | 145897 | 64216826 |
Intestinal obstruction | 203.24 | 12.49 | 312 | 135697 | 35974 | 64326749 |
Pulmonary embolism | 201.74 | 12.49 | 723 | 135286 | 145633 | 64217090 |
Pain | 180.76 | 12.49 | 583 | 135426 | 552928 | 63809795 |
Injection site pain | 178.84 | 12.49 | 15 | 135994 | 111393 | 64251330 |
Therapeutic product effect decreased | 178.56 | 12.49 | 18 | 135991 | 115333 | 64247390 |
Abdominal discomfort | 174.56 | 12.49 | 83 | 135926 | 182239 | 64180484 |
Abdominal pain | 172.36 | 12.49 | 1188 | 134821 | 311187 | 64051536 |
Peripheral swelling | 171.85 | 12.49 | 115 | 135894 | 209038 | 64153685 |
Nasopharyngitis | 169.06 | 12.49 | 102 | 135907 | 195971 | 64166752 |
Pain in extremity | 168.60 | 12.49 | 236 | 135773 | 302849 | 64059874 |
Swelling | 167.65 | 12.49 | 64 | 135945 | 160154 | 64202569 |
Metastases to lymph nodes | 164.71 | 12.49 | 141 | 135868 | 8576 | 64354147 |
Extravasation | 158.29 | 12.49 | 93 | 135916 | 3087 | 64359636 |
Depression | 155.72 | 12.49 | 97 | 135912 | 183194 | 64179529 |
Asthenia | 155.21 | 12.49 | 1479 | 134530 | 426565 | 63936158 |
Product use issue | 153.18 | 12.49 | 64 | 135945 | 151651 | 64211072 |
Contusion | 152.29 | 12.49 | 28 | 135981 | 113937 | 64248786 |
Anxiety | 150.25 | 12.49 | 124 | 135885 | 202525 | 64160198 |
Ileus | 148.07 | 12.49 | 211 | 135798 | 22755 | 64339968 |
Oesophageal fistula | 145.95 | 12.49 | 45 | 135964 | 266 | 64362457 |
Contraindicated product administered | 145.15 | 12.49 | 26 | 135983 | 107803 | 64254920 |
Arthropathy | 144.91 | 12.49 | 38 | 135971 | 120929 | 64241794 |
Anaemia | 144.51 | 12.49 | 1323 | 134686 | 377357 | 63985366 |
Drug hypersensitivity | 140.54 | 12.49 | 177 | 135832 | 237638 | 64125085 |
Systemic lupus erythematosus | 137.92 | 12.49 | 6 | 136003 | 77606 | 64285117 |
Therapy partial responder | 137.67 | 12.49 | 137 | 135872 | 10111 | 64352612 |
Hypokalaemia | 137.36 | 12.49 | 565 | 135444 | 121338 | 64241385 |
Posterior reversible encephalopathy syndrome | 135.14 | 12.49 | 202 | 135807 | 22744 | 64339979 |
Chills | 134.57 | 12.49 | 610 | 135399 | 136654 | 64226069 |
Focal nodular hyperplasia | 134.29 | 12.49 | 51 | 135958 | 606 | 64362117 |
Musculoskeletal stiffness | 130.91 | 12.49 | 48 | 135961 | 123158 | 64239565 |
Second primary malignancy | 130.19 | 12.49 | 145 | 135864 | 12192 | 64350531 |
Carcinoembryonic antigen increased | 129.49 | 12.49 | 68 | 135941 | 1805 | 64360918 |
Metastases to bone | 127.72 | 12.49 | 185 | 135824 | 20250 | 64342473 |
Large intestine perforation | 127.64 | 12.49 | 145 | 135864 | 12459 | 64350264 |
Hypertransaminasaemia | 127.15 | 12.49 | 112 | 135897 | 7079 | 64355644 |
Insomnia | 126.80 | 12.49 | 138 | 135871 | 197698 | 64165025 |
Administration site extravasation | 126.67 | 12.49 | 56 | 135953 | 1003 | 64361720 |
Colorectal cancer metastatic | 125.36 | 12.49 | 54 | 135955 | 906 | 64361817 |
Pneumatosis intestinalis | 124.97 | 12.49 | 97 | 135912 | 5132 | 64357591 |
Laryngospasm | 124.03 | 12.49 | 82 | 135927 | 3363 | 64359360 |
Ascites | 121.64 | 12.49 | 346 | 135663 | 61655 | 64301068 |
Acute promyelocytic leukaemia | 121.15 | 12.49 | 59 | 135950 | 1329 | 64361394 |
Intentional product misuse | 120.95 | 12.49 | 8 | 136001 | 72287 | 64290436 |
Peritonitis | 120.67 | 12.49 | 201 | 135808 | 24822 | 64337901 |
Influenza | 119.25 | 12.49 | 38 | 135971 | 106493 | 64256230 |
Suicide attempt | 118.37 | 12.49 | 8 | 136001 | 70999 | 64291724 |
Somnolence | 117.78 | 12.49 | 154 | 135855 | 203491 | 64159232 |
Portal venous gas | 116.25 | 12.49 | 39 | 135970 | 313 | 64362410 |
Leukoencephalopathy | 116.23 | 12.49 | 105 | 135904 | 6862 | 64355861 |
Hospitalisation | 115.69 | 12.49 | 12 | 135997 | 75195 | 64287528 |
Rhabdomyolysis | 113.36 | 12.49 | 27 | 135982 | 91699 | 64271024 |
Arthritis | 113.25 | 12.49 | 20 | 135989 | 83794 | 64278929 |
Venoocclusive liver disease | 113.13 | 12.49 | 122 | 135887 | 9893 | 64352830 |
Psoriasis | 111.45 | 12.49 | 11 | 135998 | 71692 | 64291031 |
Intestinal perforation | 111.19 | 12.49 | 149 | 135860 | 15164 | 64347559 |
Ejection fraction decreased | 110.59 | 12.49 | 209 | 135800 | 28498 | 64334225 |
Cardiomyopathy | 108.28 | 12.49 | 193 | 135816 | 25163 | 64337560 |
Cholangitis | 107.24 | 12.49 | 123 | 135886 | 10679 | 64352044 |
Hiccups | 107.06 | 12.49 | 109 | 135900 | 8267 | 64354456 |
Dizziness | 106.92 | 12.49 | 505 | 135504 | 429658 | 63933065 |
Electrocardiogram ST segment elevation | 106.79 | 12.49 | 102 | 135907 | 7157 | 64355566 |
Subileus | 105.41 | 12.49 | 86 | 135923 | 4891 | 64357832 |
Stress cardiomyopathy | 104.97 | 12.49 | 113 | 135896 | 9144 | 64353579 |
Septic shock | 104.38 | 12.49 | 470 | 135539 | 104967 | 64257756 |
Suicidal ideation | 103.97 | 12.49 | 10 | 135999 | 66532 | 64296191 |
Neutropenic sepsis | 103.07 | 12.49 | 180 | 135829 | 23092 | 64339631 |
Neutropenic colitis | 103.06 | 12.49 | 82 | 135927 | 4499 | 64358224 |
Chronic obstructive pulmonary disease | 102.70 | 12.49 | 14 | 135995 | 71034 | 64291689 |
Anastomotic leak | 102.56 | 12.49 | 47 | 135962 | 919 | 64361804 |
Overdose | 100.36 | 12.49 | 113 | 135896 | 159453 | 64203270 |
Skin reaction | 100.29 | 12.49 | 127 | 135882 | 12225 | 64350498 |
Rash pustular | 98.88 | 12.49 | 113 | 135896 | 9772 | 64352951 |
Tumour necrosis | 98.51 | 12.49 | 55 | 135954 | 1654 | 64361069 |
Epistaxis | 94.57 | 12.49 | 434 | 135575 | 97697 | 64265026 |
Maternal exposure during pregnancy | 94.28 | 12.49 | 42 | 135967 | 95842 | 64266881 |
Injury | 94.24 | 12.49 | 6 | 136003 | 55986 | 64306737 |
Wound | 93.54 | 12.49 | 23 | 135986 | 76454 | 64286269 |
Injection site erythema | 93.28 | 12.49 | 18 | 135991 | 70782 | 64291941 |
Asthma | 93.18 | 12.49 | 42 | 135967 | 95183 | 64267540 |
Bronchitis | 93.07 | 12.49 | 57 | 135952 | 108686 | 64254037 |
Cholinergic syndrome | 92.60 | 12.49 | 42 | 135967 | 801 | 64361922 |
Pemphigus | 92.56 | 12.49 | 10 | 135999 | 60691 | 64302032 |
Small intestinal obstruction | 92.52 | 12.49 | 173 | 135836 | 23400 | 64339323 |
Pelvic abscess | 91.94 | 12.49 | 54 | 135955 | 1791 | 64360932 |
Feeling abnormal | 91.47 | 12.49 | 88 | 135921 | 133514 | 64229209 |
Aorto-oesophageal fistula | 90.80 | 12.49 | 23 | 135986 | 55 | 64362668 |
Myalgia | 90.62 | 12.49 | 121 | 135888 | 158496 | 64204227 |
Stress | 89.73 | 12.49 | 11 | 135998 | 60523 | 64302200 |
Wheezing | 89.72 | 12.49 | 29 | 135980 | 80550 | 64282173 |
Electrocardiogram QT prolonged | 89.51 | 12.49 | 28 | 135981 | 79420 | 64283303 |
Non-cirrhotic portal hypertension | 89.25 | 12.49 | 33 | 135976 | 362 | 64362361 |
Dermatitis | 88.51 | 12.49 | 146 | 135863 | 17883 | 64344840 |
Migraine | 86.79 | 12.49 | 14 | 135995 | 62663 | 64300060 |
White blood cell count decreased | 86.08 | 12.49 | 599 | 135410 | 157238 | 64205485 |
Condition aggravated | 85.72 | 12.49 | 449 | 135560 | 371977 | 63990746 |
Mucosal toxicity | 85.69 | 12.49 | 34 | 135975 | 458 | 64362265 |
Nodular regenerative hyperplasia | 85.12 | 12.49 | 40 | 135969 | 830 | 64361893 |
Hepatic enzyme increased | 85.05 | 12.49 | 89 | 135920 | 129854 | 64232869 |
Pneumonia | 84.09 | 12.49 | 765 | 135244 | 558811 | 63803912 |
Rectal perforation | 83.91 | 12.49 | 38 | 135971 | 722 | 64362001 |
Osteoarthritis | 83.66 | 12.49 | 16 | 135993 | 63320 | 64299403 |
Fluid retention | 83.24 | 12.49 | 13 | 135996 | 59593 | 64303130 |
Device related infection | 82.93 | 12.49 | 193 | 135816 | 30433 | 64332290 |
Glossodynia | 82.02 | 12.49 | 18 | 135991 | 64678 | 64298045 |
Drug intolerance | 81.83 | 12.49 | 171 | 135838 | 187821 | 64174902 |
Acute coronary syndrome | 81.19 | 12.49 | 146 | 135863 | 19164 | 64343559 |
Dry skin | 81.12 | 12.49 | 265 | 135744 | 50896 | 64311827 |
Ileal perforation | 80.96 | 12.49 | 39 | 135970 | 857 | 64361866 |
Splenomegaly | 80.94 | 12.49 | 140 | 135869 | 17821 | 64344902 |
Aggression | 80.75 | 12.49 | 4 | 136005 | 46228 | 64316495 |
Mobility decreased | 80.70 | 12.49 | 40 | 135969 | 85800 | 64276923 |
Aortic thrombosis | 79.92 | 12.49 | 46 | 135963 | 1468 | 64361255 |
Confusional state | 79.55 | 12.49 | 283 | 135726 | 260861 | 64101862 |
Tumour perforation | 78.77 | 12.49 | 29 | 135980 | 314 | 64362409 |
Hyperbilirubinaemia | 78.74 | 12.49 | 152 | 135857 | 21053 | 64341670 |
Intravascular haemolysis | 76.35 | 12.49 | 35 | 135974 | 685 | 64362038 |
Device related thrombosis | 75.96 | 12.49 | 50 | 135959 | 2035 | 64360688 |
Treatment failure | 75.34 | 12.49 | 81 | 135928 | 116735 | 64245988 |
Bradycardia | 75.11 | 12.49 | 83 | 135926 | 118136 | 64244587 |
Incorrect dose administered | 74.85 | 12.49 | 18 | 135991 | 60747 | 64301976 |
Dihydropyrimidine dehydrogenase deficiency | 74.75 | 12.49 | 22 | 135987 | 108 | 64362615 |
Blood cholesterol increased | 74.45 | 12.49 | 9 | 136000 | 50057 | 64312666 |
Venous thrombosis | 74.31 | 12.49 | 79 | 135930 | 6302 | 64356421 |
Disseminated intravascular coagulation | 73.93 | 12.49 | 191 | 135818 | 32157 | 64330566 |
Metastases to peritoneum | 72.42 | 12.49 | 60 | 135949 | 3487 | 64359236 |
Gait disturbance | 72.09 | 12.49 | 160 | 135849 | 171995 | 64190728 |
Vena cava thrombosis | 72.08 | 12.49 | 52 | 135957 | 2460 | 64360263 |
Lower respiratory tract infection | 71.18 | 12.49 | 57 | 135952 | 94557 | 64268166 |
Enterocutaneous fistula | 70.90 | 12.49 | 43 | 135966 | 1514 | 64361209 |
Colitis | 70.06 | 12.49 | 277 | 135732 | 58397 | 64304326 |
Subacute cutaneous lupus erythematosus | 69.88 | 12.49 | 55 | 135954 | 2970 | 64359753 |
Discomfort | 69.75 | 12.49 | 42 | 135967 | 80836 | 64281887 |
Loss of personal independence in daily activities | 69.26 | 12.49 | 33 | 135976 | 72421 | 64290302 |
Memory impairment | 69.12 | 12.49 | 48 | 135961 | 85634 | 64277089 |
Large intestinal obstruction | 68.69 | 12.49 | 52 | 135957 | 2650 | 64360073 |
Nicotinic acid deficiency | 68.27 | 12.49 | 21 | 135988 | 123 | 64362600 |
Injection site swelling | 67.93 | 12.49 | 5 | 136004 | 41348 | 64321375 |
Gastrointestinal necrosis | 67.54 | 12.49 | 67 | 135942 | 4925 | 64357798 |
Necrotising fasciitis | 67.51 | 12.49 | 69 | 135940 | 5257 | 64357466 |
Anastomotic complication | 67.36 | 12.49 | 27 | 135982 | 374 | 64362349 |
Irritable bowel syndrome | 66.02 | 12.49 | 3 | 136006 | 37366 | 64325357 |
Injection site reaction | 65.57 | 12.49 | 10 | 135999 | 46654 | 64316069 |
Balance disorder | 65.11 | 12.49 | 49 | 135960 | 83877 | 64278846 |
Left ventricular dysfunction | 64.76 | 12.49 | 123 | 135886 | 16831 | 64345892 |
Cough | 64.69 | 12.49 | 373 | 135636 | 301775 | 64060948 |
Hallucination | 63.90 | 12.49 | 37 | 135972 | 72751 | 64289972 |
Pruritus | 63.54 | 12.49 | 392 | 135617 | 312008 | 64050715 |
Liver abscess | 62.60 | 12.49 | 66 | 135943 | 5214 | 64357509 |
Acute abdomen | 62.35 | 12.49 | 50 | 135959 | 2774 | 64359949 |
Exposure during pregnancy | 62.01 | 12.49 | 44 | 135965 | 77631 | 64285092 |
Urticaria | 61.60 | 12.49 | 137 | 135872 | 147180 | 64215543 |
Deep vein thrombosis | 60.78 | 12.49 | 405 | 135604 | 104777 | 64257946 |
Febrile bone marrow aplasia | 60.52 | 12.49 | 95 | 135914 | 11160 | 64351563 |
Tumour lysis syndrome | 59.91 | 12.49 | 129 | 135880 | 19311 | 64343412 |
Hypertension | 59.40 | 12.49 | 820 | 135189 | 258441 | 64104282 |
Helicobacter infection | 59.31 | 12.49 | 6 | 136003 | 38356 | 64324367 |
Tremor | 58.64 | 12.49 | 142 | 135867 | 148088 | 64214635 |
Cardiac failure congestive | 58.31 | 12.49 | 117 | 135892 | 130463 | 64232260 |
Hypophagia | 58.28 | 12.49 | 200 | 135809 | 39387 | 64323336 |
Blister | 58.17 | 12.49 | 51 | 135958 | 80916 | 64281807 |
Sedation | 57.99 | 12.49 | 9 | 136000 | 41453 | 64321270 |
Colony stimulating factor therapy | 57.65 | 12.49 | 26 | 135983 | 489 | 64362234 |
Emotional distress | 57.41 | 12.49 | 5 | 136004 | 36033 | 64326690 |
Respiratory arrest | 57.35 | 12.49 | 20 | 135989 | 52965 | 64309758 |
Embolism | 57.28 | 12.49 | 97 | 135912 | 12138 | 64350585 |
Dysphonia | 56.20 | 12.49 | 220 | 135789 | 46162 | 64316561 |
Sepsis | 55.83 | 12.49 | 736 | 135273 | 229605 | 64133118 |
Blood pressure fluctuation | 55.43 | 12.49 | 20 | 135989 | 51851 | 64310872 |
Treatment noncompliance | 55.31 | 12.49 | 12 | 135997 | 43470 | 64319253 |
Dysgeusia | 54.47 | 12.49 | 220 | 135789 | 46827 | 64315896 |
Heart rate decreased | 54.31 | 12.49 | 24 | 135985 | 55043 | 64307680 |
Nasal congestion | 54.28 | 12.49 | 29 | 135980 | 59629 | 64303094 |
Recall phenomenon | 54.26 | 12.49 | 31 | 135978 | 975 | 64361748 |
Plasma cell myeloma | 54.16 | 12.49 | 15 | 135994 | 46060 | 64316663 |
Coronary artery disease | 54.08 | 12.49 | 30 | 135979 | 60403 | 64302320 |
Small intestinal perforation | 53.42 | 12.49 | 44 | 135965 | 2536 | 64360187 |
Biliary tract infection | 53.17 | 12.49 | 30 | 135979 | 921 | 64361802 |
Anastomotic fistula | 53.17 | 12.49 | 16 | 135993 | 86 | 64362637 |
Haemolytic anaemia | 52.33 | 12.49 | 109 | 135900 | 15944 | 64346779 |
Hepatic lesion | 52.30 | 12.49 | 63 | 135946 | 5761 | 64356962 |
Intentional product use issue | 52.18 | 12.49 | 75 | 135934 | 95289 | 64267434 |
Carbohydrate antigen 19-9 increased | 51.74 | 12.49 | 22 | 135987 | 357 | 64362366 |
Pulmonary artery thrombosis | 51.58 | 12.49 | 32 | 135977 | 1174 | 64361549 |
Duodenal perforation | 51.50 | 12.49 | 38 | 135971 | 1862 | 64360861 |
Unevaluable event | 51.40 | 12.49 | 21 | 135988 | 50468 | 64312255 |
Trichomegaly | 51.24 | 12.49 | 15 | 135994 | 72 | 64362651 |
International normalised ratio increased | 50.92 | 12.49 | 55 | 135954 | 79112 | 64283611 |
Intestinal ischaemia | 50.71 | 12.49 | 89 | 135920 | 11460 | 64351263 |
Renal salt-wasting syndrome | 50.60 | 12.49 | 23 | 135986 | 441 | 64362282 |
Skin fissures | 49.97 | 12.49 | 83 | 135926 | 10223 | 64352500 |
Conjunctival filtering bleb leak | 49.87 | 12.49 | 12 | 135997 | 21 | 64362702 |
Portal vein thrombosis | 49.83 | 12.49 | 57 | 135952 | 4934 | 64357789 |
Toxicity to various agents | 49.79 | 12.49 | 508 | 135501 | 363005 | 63999718 |
Oesophagitis | 49.72 | 12.49 | 128 | 135881 | 21502 | 64341221 |
Muscle spasms | 49.04 | 12.49 | 144 | 135865 | 140879 | 64221844 |
Blood glucose increased | 49.01 | 12.49 | 82 | 135927 | 97991 | 64264732 |
Metastasis | 48.54 | 12.49 | 60 | 135949 | 5635 | 64357088 |
Vasospasm | 48.18 | 12.49 | 28 | 135981 | 910 | 64361813 |
Proctalgia | 48.06 | 12.49 | 69 | 135940 | 7490 | 64355233 |
Red blood cell sedimentation rate increased | 47.99 | 12.49 | 5 | 136004 | 31230 | 64331493 |
Hypoglycaemia | 47.91 | 12.49 | 72 | 135937 | 89820 | 64272903 |
Fistula | 47.85 | 12.49 | 79 | 135930 | 9682 | 64353041 |
Hyperkalaemia | 47.42 | 12.49 | 88 | 135921 | 101041 | 64261682 |
Jugular vein thrombosis | 47.41 | 12.49 | 49 | 135960 | 3782 | 64358941 |
Agitation | 46.88 | 12.49 | 71 | 135938 | 88296 | 64274427 |
Steatohepatitis | 46.47 | 12.49 | 26 | 135983 | 785 | 64361938 |
Skin disorder | 46.25 | 12.49 | 146 | 135863 | 27534 | 64335189 |
Blood pressure increased | 46.09 | 12.49 | 197 | 135812 | 172355 | 64190368 |
Enterocolitis | 45.67 | 12.49 | 87 | 135922 | 11931 | 64350792 |
Oesophageal stenosis | 45.59 | 12.49 | 48 | 135961 | 3786 | 64358937 |
Immune thrombocytopenia | 45.31 | 12.49 | 99 | 135910 | 14967 | 64347756 |
Hypoalbuminaemia | 45.27 | 12.49 | 109 | 135900 | 17565 | 64345158 |
Irritability | 45.03 | 12.49 | 11 | 135998 | 36735 | 64325988 |
Dysarthria | 44.67 | 12.49 | 245 | 135764 | 59161 | 64303562 |
Drug level increased | 44.40 | 12.49 | 9 | 136000 | 34187 | 64328536 |
Dysphagia | 44.07 | 12.49 | 380 | 135629 | 106432 | 64256291 |
Acral peeling skin syndrome | 43.57 | 12.49 | 12 | 135997 | 44 | 64362679 |
Toxic leukoencephalopathy | 43.55 | 12.49 | 26 | 135983 | 889 | 64361834 |
Pelvic fluid collection | 43.30 | 12.49 | 23 | 135986 | 625 | 64362098 |
COVID-19 | 43.30 | 12.49 | 44 | 135965 | 65096 | 64297627 |
Congestive cardiomyopathy | 43.21 | 12.49 | 78 | 135931 | 10266 | 64352457 |
Stoma site haemorrhage | 43.13 | 12.49 | 32 | 135977 | 1581 | 64361142 |
Psychotic disorder | 43.06 | 12.49 | 10 | 135999 | 34568 | 64328155 |
Adverse drug reaction | 43.00 | 12.49 | 21 | 135988 | 45443 | 64317280 |
Subclavian vein thrombosis | 42.84 | 12.49 | 37 | 135972 | 2277 | 64360446 |
Sleep apnoea syndrome | 42.82 | 12.49 | 6 | 136003 | 29826 | 64332897 |
Underdose | 42.78 | 12.49 | 3 | 136006 | 25826 | 64336897 |
Herpes zoster | 42.61 | 12.49 | 63 | 135946 | 79124 | 64283599 |
Metastases to meninges | 42.25 | 12.49 | 40 | 135969 | 2775 | 64359948 |
Hypervolaemia | 42.22 | 12.49 | 14 | 135995 | 38271 | 64324452 |
Gastrooesophageal reflux disease | 42.02 | 12.49 | 69 | 135940 | 83074 | 64279649 |
Odynophagia | 41.95 | 12.49 | 74 | 135935 | 9567 | 64353156 |
Cellulitis | 41.73 | 12.49 | 84 | 135925 | 93573 | 64269150 |
Gastric perforation | 41.70 | 12.49 | 44 | 135965 | 3479 | 64359244 |
Metastases to skin | 41.53 | 12.49 | 30 | 135979 | 1422 | 64361301 |
Myocardial infarction | 41.47 | 12.49 | 194 | 135815 | 165627 | 64197096 |
Metastases to central nervous system | 41.37 | 12.49 | 91 | 135918 | 13821 | 64348902 |
Drug ineffective for unapproved indication | 40.82 | 12.49 | 8 | 136001 | 31125 | 64331598 |
Blood pressure systolic increased | 40.82 | 12.49 | 27 | 135982 | 49426 | 64313297 |
Liver function test abnormal | 40.78 | 12.49 | 39 | 135970 | 59362 | 64303361 |
Aplasia | 40.63 | 12.49 | 61 | 135948 | 6892 | 64355831 |
Prinzmetal angina | 40.60 | 12.49 | 30 | 135979 | 1473 | 64361250 |
Gastrointestinal anastomotic leak | 40.49 | 12.49 | 19 | 135990 | 393 | 64362330 |
Venous thrombosis limb | 40.31 | 12.49 | 45 | 135964 | 3792 | 64358931 |
Transdifferentiation of neoplasm | 40.29 | 12.49 | 13 | 135996 | 91 | 64362632 |
Gastrointestinal stoma complication | 40.02 | 12.49 | 35 | 135974 | 2191 | 64360532 |
Palpitations | 39.83 | 12.49 | 102 | 135907 | 104386 | 64258337 |
Pulmonary fibrosis | 39.73 | 12.49 | 146 | 135863 | 29732 | 64332991 |
Injection site haemorrhage | 39.69 | 12.49 | 3 | 136006 | 24275 | 64338448 |
Bacterial translocation | 39.59 | 12.49 | 19 | 135990 | 414 | 64362309 |
Tumour ulceration | 39.36 | 12.49 | 15 | 135994 | 180 | 64362543 |
Conjunctivitis | 39.33 | 12.49 | 113 | 135896 | 20241 | 64342482 |
Cachexia | 39.14 | 12.49 | 70 | 135939 | 9147 | 64353576 |
Aortitis | 39.14 | 12.49 | 26 | 135983 | 1075 | 64361648 |
Varices oesophageal | 38.91 | 12.49 | 51 | 135958 | 5079 | 64357644 |
Nephrolithiasis | 38.63 | 12.49 | 22 | 135987 | 43661 | 64319062 |
Proctitis | 38.37 | 12.49 | 40 | 135969 | 3119 | 64359604 |
Full blood count abnormal | 38.28 | 12.49 | 8 | 136001 | 29749 | 64332974 |
Anal haemorrhage | 38.27 | 12.49 | 41 | 135968 | 3299 | 64359424 |
Withdrawal syndrome | 38.13 | 12.49 | 3 | 136006 | 23489 | 64339234 |
Encapsulating peritoneal sclerosis | 38.12 | 12.49 | 23 | 135986 | 802 | 64361921 |
Head injury | 38.03 | 12.49 | 11 | 135998 | 32831 | 64329892 |
Enterovesical fistula | 37.67 | 12.49 | 24 | 135985 | 923 | 64361800 |
Wrong technique in product usage process | 37.66 | 12.49 | 49 | 135960 | 64925 | 64297798 |
Dyskinesia | 37.55 | 12.49 | 18 | 135991 | 39370 | 64323353 |
Fistula of small intestine | 37.54 | 12.49 | 21 | 135988 | 634 | 64362089 |
Type II hypersensitivity | 37.12 | 12.49 | 10 | 135999 | 33 | 64362690 |
Troponin I increased | 37.07 | 12.49 | 43 | 135966 | 3778 | 64358945 |
Short-bowel syndrome | 36.78 | 12.49 | 18 | 135991 | 410 | 64362313 |
Agranulocytosis | 36.74 | 12.49 | 169 | 135840 | 38060 | 64324663 |
Colon cancer recurrent | 36.48 | 12.49 | 12 | 135997 | 90 | 64362633 |
Accidental exposure to product | 36.25 | 12.49 | 6 | 136003 | 26358 | 64336365 |
Upper respiratory tract infection | 36.23 | 12.49 | 61 | 135948 | 72724 | 64289999 |
Colon cancer metastatic | 36.11 | 12.49 | 31 | 135978 | 1892 | 64360831 |
Nephrotic syndrome | 36.03 | 12.49 | 69 | 135940 | 9498 | 64353225 |
Abnormal behaviour | 35.86 | 12.49 | 13 | 135996 | 33609 | 64329114 |
Malignant ascites | 35.66 | 12.49 | 24 | 135985 | 1014 | 64361709 |
Hepatic failure | 35.50 | 12.49 | 219 | 135790 | 55175 | 64307548 |
Cytomegalovirus infection | 35.46 | 12.49 | 17 | 135992 | 37182 | 64325541 |
K-ras gene mutation | 35.43 | 12.49 | 10 | 135999 | 41 | 64362682 |
Product prescribing error | 35.37 | 12.49 | 15 | 135994 | 35254 | 64327469 |
Dysaesthesia | 35.34 | 12.49 | 48 | 135961 | 4947 | 64357776 |
Ocular toxicity | 35.10 | 12.49 | 20 | 135989 | 626 | 64362097 |
Illness | 35.06 | 12.49 | 3 | 136006 | 21935 | 64340788 |
Right ventricular ejection fraction decreased | 35.05 | 12.49 | 10 | 135999 | 43 | 64362680 |
Hypovolaemic shock | 34.99 | 12.49 | 71 | 135938 | 10195 | 64352528 |
Poisoning | 34.94 | 12.49 | 3 | 136006 | 21876 | 64340847 |
Superior vena cava syndrome | 34.90 | 12.49 | 24 | 135985 | 1051 | 64361672 |
Heart rate increased | 34.85 | 12.49 | 100 | 135909 | 98575 | 64264148 |
Sleep disorder | 34.63 | 12.49 | 45 | 135964 | 59664 | 64303059 |
Factor VII deficiency | 34.57 | 12.49 | 9 | 136000 | 25 | 64362698 |
Xerosis | 34.55 | 12.49 | 23 | 135986 | 954 | 64361769 |
Vision blurred | 34.55 | 12.49 | 88 | 135921 | 90228 | 64272495 |
Miller Fisher syndrome | 34.49 | 12.49 | 13 | 135996 | 151 | 64362572 |
Rib fracture | 34.12 | 12.49 | 5 | 136004 | 24033 | 64338690 |
Eosinophilia | 33.92 | 12.49 | 19 | 135990 | 38057 | 64324666 |
Atypical haemolytic uraemic syndrome | 33.82 | 12.49 | 20 | 135989 | 672 | 64362051 |
Joint stiffness | 33.73 | 12.49 | 11 | 135998 | 30393 | 64332330 |
Viral infection | 33.72 | 12.49 | 17 | 135992 | 36123 | 64326600 |
Haemolytic uraemic syndrome | 33.69 | 12.49 | 42 | 135967 | 3979 | 64358744 |
Off label use | 33.36 | 12.49 | 1642 | 134367 | 631164 | 63731559 |
Splenic artery thrombosis | 33.35 | 12.49 | 10 | 135999 | 53 | 64362670 |
Type 2 diabetes mellitus | 33.28 | 12.49 | 15 | 135994 | 34005 | 64328718 |
Productive cough | 33.17 | 12.49 | 65 | 135944 | 73138 | 64289585 |
C-reactive protein abnormal | 33.14 | 12.49 | 10 | 135999 | 29037 | 64333686 |
Hepatitis B | 33.12 | 12.49 | 59 | 135950 | 7686 | 64355037 |
Hypertensive crisis | 33.05 | 12.49 | 99 | 135910 | 18149 | 64344574 |
Female genital tract fistula | 32.90 | 12.49 | 34 | 135975 | 2624 | 64360099 |
Anal erythema | 32.77 | 12.49 | 13 | 135996 | 175 | 64362548 |
Performance status decreased | 32.70 | 12.49 | 48 | 135961 | 5316 | 64357407 |
Radiation skin injury | 32.50 | 12.49 | 25 | 135984 | 1305 | 64361418 |
Sopor | 32.44 | 12.49 | 11 | 135998 | 29650 | 64333073 |
Therapy cessation | 32.29 | 12.49 | 14 | 135995 | 32475 | 64330248 |
Incorrect drug administration rate | 32.26 | 12.49 | 34 | 135975 | 2685 | 64360038 |
Perineal disorder | 32.23 | 12.49 | 8 | 136001 | 17 | 64362706 |
Oesophageal varices haemorrhage | 32.17 | 12.49 | 39 | 135970 | 3590 | 64359133 |
Oral pain | 32.17 | 12.49 | 129 | 135880 | 27364 | 64335359 |
Refeeding syndrome | 32.17 | 12.49 | 10 | 135999 | 61 | 64362662 |
Rectal haemorrhage | 32.14 | 12.49 | 232 | 135777 | 61585 | 64301138 |
Joint injury | 32.05 | 12.49 | 5 | 136004 | 22942 | 64339781 |
Adverse event | 32.00 | 12.49 | 22 | 135987 | 39467 | 64323256 |
Diabetes mellitus | 31.91 | 12.49 | 57 | 135952 | 66417 | 64296306 |
Lung neoplasm malignant | 31.53 | 12.49 | 4 | 136005 | 21444 | 64341279 |
Adenocarcinoma of colon | 31.49 | 12.49 | 45 | 135964 | 4863 | 64357860 |
Cardiac disorder | 31.42 | 12.49 | 43 | 135966 | 55773 | 64306950 |
Pulmonary toxicity | 31.33 | 12.49 | 61 | 135948 | 8500 | 64354223 |
Neck pain | 31.15 | 12.49 | 51 | 135958 | 61482 | 64301241 |
Thrombocytopenic purpura | 31.08 | 12.49 | 30 | 135979 | 2132 | 64360591 |
Oesophageal perforation | 30.90 | 12.49 | 22 | 135987 | 1019 | 64361704 |
Visual impairment | 30.86 | 12.49 | 69 | 135940 | 74008 | 64288715 |
Cytomegalovirus oesophagitis | 30.78 | 12.49 | 18 | 135991 | 592 | 64362131 |
Cataract | 30.39 | 12.49 | 38 | 135971 | 51224 | 64311499 |
Blood creatine phosphokinase increased | 30.15 | 12.49 | 48 | 135961 | 58510 | 64304213 |
Tumour haemorrhage | 30.09 | 12.49 | 37 | 135972 | 3456 | 64359267 |
Cardiac arrest | 29.89 | 12.49 | 196 | 135813 | 153868 | 64208855 |
Myoclonus | 29.85 | 12.49 | 8 | 136001 | 25110 | 64337613 |
Road traffic accident | 29.38 | 12.49 | 14 | 135995 | 30731 | 64331992 |
Crying | 28.93 | 12.49 | 4 | 136005 | 20086 | 64342637 |
Tumour marker increased | 28.85 | 12.49 | 36 | 135973 | 3414 | 64359309 |
Diaphragmatic paralysis | 28.75 | 12.49 | 21 | 135988 | 1013 | 64361710 |
Mental disorder | 28.59 | 12.49 | 10 | 135999 | 26435 | 64336288 |
Pneumonitis | 28.52 | 12.49 | 193 | 135816 | 50172 | 64312551 |
Duodenal ulcer perforation | 28.45 | 12.49 | 19 | 135990 | 34606 | 64328117 |
Toxic epidermal necrolysis | 28.44 | 12.49 | 22 | 135987 | 37144 | 64325579 |
Hepatic atrophy | 28.26 | 12.49 | 15 | 135994 | 407 | 64362316 |
Aphthous ulcer | 28.25 | 12.49 | 75 | 135934 | 12831 | 64349892 |
Accidental overdose | 28.13 | 12.49 | 18 | 135991 | 33539 | 64329184 |
Pregnancy | 28.13 | 12.49 | 5 | 136004 | 20860 | 64341863 |
Nephritis bacterial | 27.93 | 12.49 | 8 | 136001 | 35 | 64362688 |
Periportal sinus dilatation | 27.93 | 12.49 | 8 | 136001 | 35 | 64362688 |
Pericarditis | 27.91 | 12.49 | 56 | 135953 | 62460 | 64300263 |
Chronic myeloid leukaemia | 27.88 | 12.49 | 35 | 135974 | 3339 | 64359384 |
Product quality issue | 27.83 | 12.49 | 14 | 135995 | 29785 | 64332938 |
Hyperthermia | 27.82 | 12.49 | 84 | 135925 | 15466 | 64347257 |
Induration | 27.60 | 12.49 | 25 | 135984 | 1639 | 64361084 |
Metastases to the mediastinum | 27.59 | 12.49 | 16 | 135993 | 518 | 64362205 |
Pancytopenia | 27.57 | 12.49 | 440 | 135569 | 142869 | 64219854 |
White blood cell count abnormal | 27.54 | 12.49 | 42 | 135967 | 4812 | 64357911 |
Portal shunt | 27.53 | 12.49 | 9 | 136000 | 66 | 64362657 |
Chronic kidney disease | 27.50 | 12.49 | 50 | 135959 | 57869 | 64304854 |
Nail disorder | 27.46 | 12.49 | 58 | 135951 | 8566 | 64354157 |
Diffuse alveolar damage | 27.44 | 12.49 | 34 | 135975 | 3201 | 64359522 |
Oesophagobronchial fistula | 27.40 | 12.49 | 12 | 135997 | 210 | 64362513 |
Prescribed underdose | 27.38 | 12.49 | 3 | 136006 | 18012 | 64344711 |
Osteoporosis | 27.32 | 12.49 | 29 | 135980 | 42051 | 64320672 |
Kidney infection | 27.03 | 12.49 | 3 | 136006 | 17835 | 64344888 |
Abdominal abscess | 26.93 | 12.49 | 48 | 135961 | 6256 | 64356467 |
Ear infection | 26.80 | 12.49 | 8 | 136001 | 23396 | 64339327 |
Cystitis radiation | 26.78 | 12.49 | 10 | 135999 | 113 | 64362610 |
Night sweats | 26.75 | 12.49 | 22 | 135987 | 36024 | 64326699 |
Multiple sclerosis | 26.74 | 12.49 | 4 | 136005 | 18937 | 64343786 |
Cell-mediated cytotoxicity | 26.74 | 12.49 | 8 | 136001 | 42 | 64362681 |
Haematoma | 26.68 | 12.49 | 35 | 135974 | 46215 | 64316508 |
Organising pneumonia | 26.66 | 12.49 | 59 | 135950 | 8996 | 64353727 |
Protein urine | 26.65 | 12.49 | 22 | 135987 | 1272 | 64361451 |
Sciatic nerve palsy | 26.64 | 12.49 | 9 | 136000 | 74 | 64362649 |
Metastases to chest wall | 26.47 | 12.49 | 14 | 135995 | 377 | 64362346 |
Pigmentation disorder | 26.29 | 12.49 | 40 | 135969 | 4572 | 64358151 |
Guillain-Barre syndrome | 26.25 | 12.49 | 53 | 135956 | 7582 | 64355141 |
Balanoposthitis | 26.22 | 12.49 | 18 | 135991 | 786 | 64361937 |
Hallucination, visual | 26.11 | 12.49 | 13 | 135996 | 27821 | 64334902 |
Urinary tract infection | 26.06 | 12.49 | 338 | 135671 | 231258 | 64131465 |
Erythema | 26.04 | 12.49 | 546 | 135463 | 186524 | 64176199 |
Cystitis | 25.97 | 12.49 | 31 | 135978 | 42644 | 64320079 |
Injection site mass | 25.93 | 12.49 | 3 | 136006 | 17267 | 64345456 |
Proteus infection | 25.92 | 12.49 | 24 | 135985 | 1619 | 64361104 |
Venous pressure jugular decreased | 25.83 | 12.49 | 9 | 136000 | 82 | 64362641 |
Koebner phenomenon | 25.71 | 12.49 | 8 | 136001 | 49 | 64362674 |
Chemotherapy | 25.70 | 12.49 | 23 | 135986 | 1484 | 64361239 |
Extrapyramidal disorder | 25.69 | 12.49 | 5 | 136004 | 19547 | 64343176 |
Back pain | 25.68 | 12.49 | 372 | 135637 | 249799 | 64112924 |
Neuromyotonia | 25.63 | 12.49 | 9 | 136000 | 84 | 64362639 |
VIth nerve disorder | 25.56 | 12.49 | 7 | 136002 | 25 | 64362698 |
NPM1 gene mutation | 25.52 | 12.49 | 10 | 135999 | 130 | 64362593 |
Pain in jaw | 25.45 | 12.49 | 29 | 135980 | 40726 | 64321997 |
Gastric disorder | 25.40 | 12.49 | 15 | 135994 | 29182 | 64333541 |
Amnesia | 25.39 | 12.49 | 39 | 135970 | 48230 | 64314493 |
Joint range of motion decreased | 25.30 | 12.49 | 5 | 136004 | 19338 | 64343385 |
Retroperitoneal abscess | 25.24 | 12.49 | 13 | 135996 | 331 | 64362392 |
Limb injury | 25.22 | 12.49 | 9 | 136000 | 23496 | 64339227 |
PIK3CA-activated mutation | 25.20 | 12.49 | 15 | 135994 | 510 | 64362213 |
Metastases to pleura | 25.01 | 12.49 | 21 | 135988 | 1243 | 64361480 |
Myocarditis | 24.99 | 12.49 | 86 | 135923 | 16957 | 64345766 |
Adenocarcinoma | 24.93 | 12.49 | 33 | 135976 | 3318 | 64359405 |
Musculoskeletal disorder | 24.78 | 12.49 | 4 | 136005 | 17902 | 64344821 |
Muscle spasticity | 24.77 | 12.49 | 3 | 136006 | 16666 | 64346057 |
Muscular weakness | 24.70 | 12.49 | 162 | 135847 | 127176 | 64235547 |
Stridor | 24.64 | 12.49 | 40 | 135969 | 4834 | 64357889 |
Ectropion | 24.62 | 12.49 | 13 | 135996 | 349 | 64362374 |
Nervousness | 24.58 | 12.49 | 16 | 135993 | 29540 | 64333183 |
Eye disorder | 24.42 | 12.49 | 5 | 136004 | 18864 | 64343859 |
Hiatus hernia | 24.40 | 12.49 | 6 | 136003 | 19951 | 64342772 |
Myopathy | 24.36 | 12.49 | 4 | 136005 | 17676 | 64345047 |
Cerebral haemorrhage | 24.35 | 12.49 | 44 | 135965 | 51046 | 64311677 |
Alopecia | 24.18 | 12.49 | 487 | 135522 | 165203 | 64197520 |
Localised infection | 24.18 | 12.49 | 17 | 135992 | 30144 | 64332579 |
Death | 24.17 | 12.49 | 805 | 135204 | 481900 | 63880823 |
Musculoskeletal discomfort | 24.02 | 12.49 | 3 | 136006 | 16274 | 64346449 |
Disturbance in attention | 23.77 | 12.49 | 31 | 135978 | 41043 | 64321680 |
Toxic erythema of chemotherapy | 23.73 | 12.49 | 11 | 135998 | 221 | 64362502 |
Gastrointestinal inflammation | 23.73 | 12.49 | 45 | 135964 | 6150 | 64356573 |
Rectal tenesmus | 23.69 | 12.49 | 19 | 135990 | 1054 | 64361669 |
Perforation bile duct | 23.68 | 12.49 | 7 | 136002 | 35 | 64362688 |
Myelodysplastic syndrome | 23.66 | 12.49 | 118 | 135891 | 27461 | 64335262 |
Gastrointestinal stoma output increased | 23.64 | 12.49 | 11 | 135998 | 223 | 64362500 |
Platelet count decreased | 23.51 | 12.49 | 490 | 135519 | 167221 | 64195502 |
Portal vein embolisation | 23.50 | 12.49 | 6 | 136003 | 15 | 64362708 |
Mood altered | 23.44 | 12.49 | 3 | 136006 | 15976 | 64346747 |
Radiation mucositis | 23.36 | 12.49 | 10 | 135999 | 165 | 64362558 |
Anal erosion | 23.20 | 12.49 | 7 | 136002 | 38 | 64362685 |
Evans syndrome | 23.13 | 12.49 | 13 | 135996 | 396 | 64362327 |
Infusion related hypersensitivity reaction | 23.09 | 12.49 | 10 | 135999 | 170 | 64362553 |
Nasal septum perforation | 23.04 | 12.49 | 16 | 135993 | 712 | 64362011 |
Inappropriate schedule of product administration | 23.04 | 12.49 | 108 | 135901 | 92178 | 64270545 |
Bacteraemia | 22.99 | 12.49 | 115 | 135894 | 26796 | 64335927 |
Anger | 22.99 | 12.49 | 3 | 136006 | 15738 | 64346985 |
Medication error | 22.96 | 12.49 | 44 | 135965 | 49922 | 64312801 |
Cardio-respiratory arrest | 22.92 | 12.49 | 118 | 135891 | 98275 | 64264448 |
Jaundice | 22.91 | 12.49 | 178 | 135831 | 48334 | 64314389 |
Laryngeal oedema | 22.84 | 12.49 | 48 | 135961 | 7065 | 64355658 |
Musculoskeletal pain | 22.82 | 12.49 | 91 | 135918 | 81203 | 64281520 |
Oesophageal haemorrhage | 22.81 | 12.49 | 22 | 135987 | 1562 | 64361161 |
Colitis ulcerative | 22.76 | 12.49 | 10 | 135999 | 23018 | 64339705 |
Faeces discoloured | 22.69 | 12.49 | 13 | 135996 | 25716 | 64337007 |
Movement disorder | 22.64 | 12.49 | 9 | 136000 | 21991 | 64340732 |
Encephalopathy | 22.57 | 12.49 | 206 | 135803 | 58613 | 64304110 |
Anal fistula | 22.44 | 12.49 | 40 | 135969 | 5213 | 64357510 |
Biliary fistula | 22.39 | 12.49 | 8 | 136001 | 79 | 64362644 |
Metastases to pelvis | 22.32 | 12.49 | 14 | 135995 | 524 | 64362199 |
Astringent therapy | 22.23 | 12.49 | 6 | 136003 | 20 | 64362703 |
Neoplasm recurrence | 22.13 | 12.49 | 33 | 135976 | 3706 | 64359017 |
Device issue | 22.13 | 12.49 | 10 | 135999 | 22638 | 64340085 |
Prothrombin level decreased | 22.08 | 12.49 | 21 | 135988 | 1465 | 64361258 |
Full blood count decreased | 22.02 | 12.49 | 10 | 135999 | 22572 | 64340151 |
Rectal cancer metastatic | 22.00 | 12.49 | 13 | 135996 | 436 | 64362287 |
Oxygen saturation decreased | 21.99 | 12.49 | 134 | 135875 | 107042 | 64255681 |
Pneumonitis chemical | 21.98 | 12.49 | 12 | 135997 | 345 | 64362378 |
Dysaesthesia pharynx | 21.80 | 12.49 | 10 | 135999 | 196 | 64362527 |
Wound dehiscence | 21.67 | 12.49 | 42 | 135967 | 5832 | 64356891 |
Gout | 21.64 | 12.49 | 9 | 136000 | 21404 | 64341319 |
Anaemia of malignant disease | 21.61 | 12.49 | 15 | 135994 | 667 | 64362056 |
Interventricular septum rupture | 21.58 | 12.49 | 6 | 136003 | 23 | 64362700 |
Gait inability | 21.55 | 12.49 | 35 | 135974 | 42333 | 64320390 |
Necrotising colitis | 21.45 | 12.49 | 17 | 135992 | 927 | 64361796 |
Eye pain | 21.43 | 12.49 | 21 | 135988 | 31604 | 64331119 |
Blood glucose decreased | 21.39 | 12.49 | 11 | 135998 | 23112 | 64339611 |
Subdural haematoma | 20.97 | 12.49 | 17 | 135992 | 28037 | 64334686 |
Delusion | 20.92 | 12.49 | 6 | 136003 | 18008 | 64344715 |
Angioedema | 20.85 | 12.49 | 64 | 135945 | 61757 | 64300966 |
Anorectal discomfort | 20.83 | 12.49 | 28 | 135981 | 2857 | 64359866 |
Anorectal disorder | 20.82 | 12.49 | 23 | 135986 | 1916 | 64360807 |
Pancreatic neuroendocrine tumour metastatic | 20.77 | 12.49 | 8 | 136001 | 99 | 64362624 |
Depressed mood | 20.75 | 12.49 | 34 | 135975 | 40978 | 64321745 |
Gastrointestinal ischaemia | 20.73 | 12.49 | 12 | 135997 | 387 | 64362336 |
Pulmonary arterial hypertension | 20.73 | 12.49 | 14 | 135995 | 25353 | 64337370 |
Fungal infection | 20.71 | 12.49 | 25 | 135984 | 34226 | 64328497 |
Microgenia | 20.69 | 12.49 | 5 | 136004 | 9 | 64362714 |
Haemoglobinuria | 20.64 | 12.49 | 15 | 135994 | 718 | 64362005 |
Pneumoperitoneum | 20.63 | 12.49 | 27 | 135982 | 2684 | 64360039 |
Radiation interaction | 20.57 | 12.49 | 7 | 136002 | 59 | 64362664 |
Ischiorectal hernia | 20.35 | 12.49 | 5 | 136004 | 10 | 64362713 |
Sarcoidosis | 20.35 | 12.49 | 42 | 135967 | 6104 | 64356619 |
Anal fissure | 20.34 | 12.49 | 37 | 135972 | 4899 | 64357824 |
Breast cancer metastatic | 20.31 | 12.49 | 46 | 135963 | 7123 | 64355600 |
Incorrect route of product administration | 20.22 | 12.49 | 12 | 135997 | 23286 | 64339437 |
Acute respiratory distress syndrome | 20.16 | 12.49 | 146 | 135863 | 38789 | 64323934 |
Respiratory disorder | 20.14 | 12.49 | 28 | 135981 | 36083 | 64326640 |
Breast cancer recurrent | 20.09 | 12.49 | 26 | 135983 | 2557 | 64360166 |
Pachymeningitis | 20.07 | 12.49 | 10 | 135999 | 237 | 64362486 |
Pseudocirrhosis | 20.00 | 12.49 | 14 | 135995 | 631 | 64362092 |
Thrombotic thrombocytopenic purpura | 19.94 | 12.49 | 41 | 135968 | 5943 | 64356780 |
Acute interstitial pneumonitis | 19.91 | 12.49 | 17 | 135992 | 1030 | 64361693 |
Pulmonary infarction | 19.88 | 12.49 | 29 | 135980 | 3193 | 64359530 |
Tendonitis | 19.75 | 12.49 | 9 | 136000 | 20273 | 64342450 |
Tympanic membrane disorder | 19.73 | 12.49 | 9 | 136000 | 174 | 64362549 |
Rash pruritic | 19.66 | 12.49 | 59 | 135950 | 57345 | 64305378 |
Intervertebral disc protrusion | 19.59 | 12.49 | 9 | 136000 | 20182 | 64342541 |
Hepatectomy | 19.59 | 12.49 | 9 | 136000 | 177 | 64362546 |
Spinal stenosis | 19.53 | 12.49 | 3 | 136006 | 13928 | 64348795 |
Depilation | 19.44 | 12.49 | 5 | 136004 | 13 | 64362710 |
Bronchiolitis obliterans syndrome | 19.44 | 12.49 | 10 | 135999 | 254 | 64362469 |
Clostridial infection | 19.38 | 12.49 | 37 | 135972 | 5082 | 64357641 |
Restless legs syndrome | 19.33 | 12.49 | 6 | 136003 | 17110 | 64345613 |
No adverse event | 19.31 | 12.49 | 19 | 135990 | 28542 | 64334181 |
Nail toxicity | 19.28 | 12.49 | 11 | 135998 | 345 | 64362378 |
Soft tissue necrosis | 19.19 | 12.49 | 14 | 135995 | 674 | 64362049 |
Renal disorder | 19.15 | 12.49 | 28 | 135981 | 35337 | 64327386 |
Intracardiac thrombus | 19.07 | 12.49 | 31 | 135978 | 3750 | 64358973 |
Vascular pain | 19.04 | 12.49 | 15 | 135994 | 811 | 64361912 |
Nodule | 19.04 | 12.49 | 7 | 136002 | 17940 | 64344783 |
Chimerism | 19.02 | 12.49 | 10 | 135999 | 266 | 64362457 |
Vocal cord paralysis | 18.92 | 12.49 | 23 | 135986 | 2123 | 64360600 |
Bile duct stenosis | 18.87 | 12.49 | 21 | 135988 | 1763 | 64360960 |
Hydronephrosis | 18.76 | 12.49 | 69 | 135940 | 14056 | 64348667 |
Hernia | 18.75 | 12.49 | 3 | 136006 | 13515 | 64349208 |
Bursitis | 18.74 | 12.49 | 11 | 135998 | 21474 | 64341249 |
Influenza like illness | 18.66 | 12.49 | 67 | 135942 | 61635 | 64301088 |
Perihepatic abscess | 18.58 | 12.49 | 8 | 136001 | 134 | 64362589 |
Metastases to spine | 18.55 | 12.49 | 30 | 135979 | 3613 | 64359110 |
Scintillating scotoma | 18.55 | 12.49 | 9 | 136000 | 201 | 64362522 |
Lip swelling | 18.55 | 12.49 | 24 | 135985 | 31883 | 64330840 |
Dyspnoea | 18.52 | 12.49 | 1286 | 134723 | 717388 | 63645335 |
Lymphadenopathy mediastinal | 18.50 | 12.49 | 31 | 135978 | 3845 | 64358878 |
Visceral venous thrombosis | 18.45 | 12.49 | 5 | 136004 | 17 | 64362706 |
Haemorrhage intracranial | 18.45 | 12.49 | 14 | 135995 | 23870 | 64338853 |
Ventricular fibrillation | 18.33 | 12.49 | 99 | 135910 | 23761 | 64338962 |
Creatinine renal clearance decreased | 18.30 | 12.49 | 4 | 136005 | 14417 | 64348306 |
Foot deformity | 18.26 | 12.49 | 6 | 136003 | 16498 | 64346225 |
Gait apraxia | 18.23 | 12.49 | 5 | 136004 | 18 | 64362705 |
Chemotherapy cardiotoxicity attenuation | 18.23 | 12.49 | 5 | 136004 | 18 | 64362705 |
Sinus congestion | 18.19 | 12.49 | 5 | 136004 | 15434 | 64347289 |
Paraesthesia oral | 18.16 | 12.49 | 65 | 135944 | 13066 | 64349657 |
Basal cell carcinoma | 18.13 | 12.49 | 23 | 135986 | 30815 | 64331908 |
Swelling face | 18.06 | 12.49 | 64 | 135945 | 59102 | 64303621 |
Peritoneal neoplasm | 18.01 | 12.49 | 7 | 136002 | 89 | 64362634 |
Neonatal asphyxia | 17.89 | 12.49 | 4 | 136005 | 4 | 64362719 |
Intrahepatic portal hepatic venous fistula | 17.89 | 12.49 | 4 | 136005 | 4 | 64362719 |
Therapy interrupted | 17.84 | 12.49 | 10 | 135999 | 20026 | 64342697 |
Thrombocytopenia neonatal | 17.81 | 12.49 | 5 | 136004 | 20 | 64362703 |
Neutrophil count abnormal | 17.77 | 12.49 | 26 | 135983 | 2870 | 64359853 |
Drug-induced liver injury | 17.77 | 12.49 | 47 | 135962 | 47596 | 64315127 |
Catabolic state | 17.73 | 12.49 | 7 | 136002 | 93 | 64362630 |
Cytokine release syndrome | 17.70 | 12.49 | 11 | 135998 | 20818 | 64341905 |
Hormone receptor positive breast cancer | 17.69 | 12.49 | 10 | 135999 | 308 | 64362415 |
Adrenal insufficiency | 17.60 | 12.49 | 13 | 135996 | 22474 | 64340249 |
Inferior vena cava stenosis | 17.58 | 12.49 | 6 | 136003 | 51 | 64362672 |
T-cell type acute leukaemia | 17.48 | 12.49 | 8 | 136001 | 156 | 64362567 |
Hypocalcaemia | 17.45 | 12.49 | 149 | 135860 | 41604 | 64321119 |
Tumour fistulisation | 17.43 | 12.49 | 5 | 136004 | 22 | 64362701 |
Skin hyperpigmentation | 17.42 | 12.49 | 41 | 135968 | 6510 | 64356213 |
Blood triglycerides increased | 17.41 | 12.49 | 9 | 136000 | 18857 | 64343866 |
Necrosis | 17.40 | 12.49 | 47 | 135962 | 8124 | 64354599 |
Cardiomyopathy acute | 17.34 | 12.49 | 9 | 136000 | 233 | 64362490 |
Gastroenteritis radiation | 17.33 | 12.49 | 13 | 135996 | 653 | 64362070 |
Hypersomnia | 17.33 | 12.49 | 10 | 135999 | 19707 | 64343016 |
Intestinal strangulation | 17.28 | 12.49 | 6 | 136003 | 54 | 64362669 |
Product substitution issue | 17.27 | 12.49 | 8 | 136001 | 17853 | 64344870 |
Limbic encephalitis | 17.25 | 12.49 | 13 | 135996 | 658 | 64362065 |
Hydrothorax | 17.24 | 12.49 | 17 | 135992 | 1240 | 64361483 |
Gastrointestinal haemorrhage | 17.21 | 12.49 | 187 | 135822 | 132125 | 64230598 |
Vaginal fistula | 17.20 | 12.49 | 9 | 136000 | 237 | 64362486 |
Hypersplenism | 17.20 | 12.49 | 11 | 135998 | 426 | 64362297 |
Colonic fistula | 17.10 | 12.49 | 12 | 135997 | 543 | 64362180 |
Recurrent cancer | 17.09 | 12.49 | 23 | 135986 | 2350 | 64360373 |
Hypercreatininaemia | 17.09 | 12.49 | 14 | 135995 | 801 | 64361922 |
Carpal tunnel syndrome | 17.08 | 12.49 | 6 | 136003 | 15822 | 64346901 |
Aortic dissection | 17.00 | 12.49 | 28 | 135981 | 3424 | 64359299 |
Labelled drug-drug interaction medication error | 16.95 | 12.49 | 13 | 135996 | 22049 | 64340674 |
Necrotising oesophagitis | 16.93 | 12.49 | 13 | 135996 | 677 | 64362046 |
Endometrial dysplasia | 16.91 | 12.49 | 5 | 136004 | 25 | 64362698 |
Rash macular | 16.91 | 12.49 | 15 | 135994 | 23670 | 64339053 |
Ankle fracture | 16.90 | 12.49 | 5 | 136004 | 14705 | 64348018 |
Hepatitis B surface antigen positive | 16.89 | 12.49 | 8 | 136001 | 169 | 64362554 |
Lymphangiosis carcinomatosa | 16.85 | 12.49 | 20 | 135989 | 1801 | 64360922 |
Dyspnoea exertional | 16.84 | 12.49 | 89 | 135920 | 73641 | 64289082 |
Haemorrhagic infarction | 16.68 | 12.49 | 13 | 135996 | 692 | 64362031 |
Metastases to ovary | 16.67 | 12.49 | 9 | 136000 | 253 | 64362470 |
Mood swings | 16.62 | 12.49 | 8 | 136001 | 17460 | 64345263 |
Oedema peripheral | 16.60 | 12.49 | 328 | 135681 | 209989 | 64152734 |
Wernicke's encephalopathy | 16.59 | 12.49 | 5 | 136004 | 27 | 64362696 |
Hypothyroidism | 16.59 | 12.49 | 38 | 135971 | 40419 | 64322304 |
Osteopenia | 16.59 | 12.49 | 6 | 136003 | 15534 | 64347189 |
Perineal abscess | 16.47 | 12.49 | 11 | 135998 | 459 | 64362264 |
Prostatic calcification | 16.46 | 12.49 | 6 | 136003 | 63 | 64362660 |
Hypocapnia | 16.44 | 12.49 | 12 | 135997 | 578 | 64362145 |
Toxic cardiomyopathy | 16.44 | 12.49 | 10 | 135999 | 354 | 64362369 |
Enterocolitis infectious | 16.41 | 12.49 | 23 | 135986 | 2441 | 64360282 |
Perioral dermatitis | 16.32 | 12.49 | 9 | 136000 | 264 | 64362459 |
Febrile infection | 16.31 | 12.49 | 25 | 135984 | 2876 | 64359847 |
Mixed adenoneuroendocrine carcinoma | 16.28 | 12.49 | 4 | 136005 | 8 | 64362715 |
Disability | 16.23 | 12.49 | 3 | 136006 | 12169 | 64350554 |
Aortic intramural haematoma | 16.22 | 12.49 | 7 | 136002 | 118 | 64362605 |
Miosis | 16.20 | 12.49 | 4 | 136005 | 13262 | 64349461 |
Mydriasis | 16.19 | 12.49 | 6 | 136003 | 15306 | 64347417 |
Splenic abscess | 16.17 | 12.49 | 11 | 135998 | 473 | 64362250 |
Obstructive airways disorder | 16.17 | 12.49 | 15 | 135994 | 23170 | 64339553 |
Viral hepatitis carrier | 16.15 | 12.49 | 5 | 136004 | 30 | 64362693 |
Sneezing | 16.09 | 12.49 | 6 | 136003 | 15245 | 64347478 |
Klebsiella infection | 16.09 | 12.49 | 63 | 135946 | 13218 | 64349505 |
Mucosal ulceration | 16.03 | 12.49 | 19 | 135990 | 1708 | 64361015 |
Hyperpyrexia | 16.00 | 12.49 | 34 | 135975 | 5043 | 64357680 |
Cyst | 15.96 | 12.49 | 3 | 136006 | 12024 | 64350699 |
Gallbladder disorder | 15.90 | 12.49 | 8 | 136001 | 17022 | 64345701 |
Hyperlipidaemia | 15.87 | 12.49 | 15 | 135994 | 22961 | 64339762 |
Glycosylated haemoglobin increased | 15.76 | 12.49 | 7 | 136002 | 16012 | 64346711 |
Electrocardiogram ST segment depression | 15.73 | 12.49 | 31 | 135978 | 4358 | 64358365 |
Peripheral sensorimotor neuropathy | 15.57 | 12.49 | 23 | 135986 | 2562 | 64360161 |
Delirium | 15.54 | 12.49 | 84 | 135925 | 69110 | 64293613 |
Cardiac ventricular thrombosis | 15.52 | 12.49 | 17 | 135992 | 1403 | 64361320 |
Herpes simplex meningomyelitis | 15.49 | 12.49 | 3 | 136006 | 0 | 64362723 |
Cholecystocholangitis | 15.49 | 12.49 | 3 | 136006 | 0 | 64362723 |
Gastrointestinal obstruction | 15.47 | 12.49 | 17 | 135992 | 1408 | 64361315 |
Peritoneal disorder | 15.42 | 12.49 | 12 | 135997 | 637 | 64362086 |
Cholelithiasis | 15.42 | 12.49 | 47 | 135962 | 45459 | 64317264 |
Soft tissue disorder | 15.37 | 12.49 | 26 | 135983 | 3250 | 64359473 |
Liver function test increased | 15.37 | 12.49 | 26 | 135983 | 30944 | 64331779 |
Therapy non-responder | 15.36 | 12.49 | 79 | 135930 | 65820 | 64296903 |
Growth of eyelashes | 15.32 | 12.49 | 7 | 136002 | 136 | 64362587 |
Ill-defined disorder | 15.29 | 12.49 | 45 | 135964 | 44007 | 64318716 |
Lactic acidosis | 15.25 | 12.49 | 72 | 135937 | 61338 | 64301385 |
Limb discomfort | 15.23 | 12.49 | 21 | 135988 | 27154 | 64335569 |
Arterial thrombosis | 15.18 | 12.49 | 22 | 135987 | 2408 | 64360315 |
Infectious pleural effusion | 15.17 | 12.49 | 24 | 135985 | 2838 | 64359885 |
Metapneumovirus bronchiolitis | 15.14 | 12.49 | 4 | 136005 | 12 | 64362711 |
Marchiafava-Bignami disease | 15.14 | 12.49 | 4 | 136005 | 12 | 64362711 |
Throat tightness | 15.11 | 12.49 | 92 | 135917 | 23068 | 64339655 |
COVID-19 pneumonia | 15.04 | 12.49 | 8 | 136001 | 16496 | 64346227 |
Hyperleukocytosis | 15.04 | 12.49 | 20 | 135989 | 2020 | 64360703 |
Tooth disorder | 15.04 | 12.49 | 15 | 135994 | 22387 | 64340336 |
Pneumomediastinum | 14.93 | 12.49 | 24 | 135985 | 2876 | 64359847 |
Ventricular hypokinesia | 14.88 | 12.49 | 43 | 135966 | 7726 | 64354997 |
Nasal crusting | 14.85 | 12.49 | 11 | 135998 | 542 | 64362181 |
Aspergillus infection | 14.84 | 12.49 | 8 | 136001 | 16371 | 64346352 |
Drug eruption | 14.77 | 12.49 | 34 | 135975 | 36102 | 64326621 |
Periodontal disease | 14.71 | 12.49 | 18 | 135991 | 1673 | 64361050 |
Monocytopenia | 14.65 | 12.49 | 7 | 136002 | 151 | 64362572 |
Thrombophlebitis | 14.62 | 12.49 | 35 | 135974 | 5619 | 64357104 |
Pneumoretroperitoneum | 14.60 | 12.49 | 6 | 136003 | 89 | 64362634 |
Respiratory alkalosis | 14.55 | 12.49 | 28 | 135981 | 3869 | 64358854 |
Temperature difference of extremities | 14.45 | 12.49 | 4 | 136005 | 15 | 64362708 |
Glomerular filtration rate decreased | 14.45 | 12.49 | 12 | 135997 | 19560 | 64343163 |
Oral dysaesthesia | 14.44 | 12.49 | 7 | 136002 | 156 | 64362567 |
Gastric varices haemorrhage | 14.41 | 12.49 | 9 | 136000 | 334 | 64362389 |
Vitamin B1 deficiency | 14.39 | 12.49 | 11 | 135998 | 569 | 64362154 |
Renal tubular disorder | 14.35 | 12.49 | 36 | 135973 | 5951 | 64356772 |
Tissue injury | 14.30 | 12.49 | 5 | 136004 | 46 | 64362677 |
Metastatic neoplasm | 14.29 | 12.49 | 30 | 135979 | 4412 | 64358311 |
Sciatica | 14.26 | 12.49 | 13 | 135996 | 20251 | 64342472 |
Duodenal varices | 14.25 | 12.49 | 4 | 136005 | 16 | 64362707 |
Stevens-Johnson syndrome | 14.18 | 12.49 | 32 | 135977 | 34217 | 64328506 |
Pulmonary alveolar haemorrhage | 14.15 | 12.49 | 49 | 135960 | 9689 | 64353034 |
Tumour invasion | 14.13 | 12.49 | 9 | 136000 | 346 | 64362377 |
Stomatitis haemorrhagic | 14.13 | 12.49 | 6 | 136003 | 97 | 64362626 |
Lymph node abscess | 14.12 | 12.49 | 5 | 136004 | 48 | 64362675 |
Dandy-Walker syndrome | 14.12 | 12.49 | 5 | 136004 | 48 | 64362675 |
Colitis microscopic | 14.10 | 12.49 | 41 | 135968 | 7391 | 64355332 |
Tetany | 14.06 | 12.49 | 20 | 135989 | 2152 | 64360571 |
ECG signs of myocardial ischaemia | 14.04 | 12.49 | 9 | 136000 | 350 | 64362373 |
Facial discomfort | 14.03 | 12.49 | 5 | 136004 | 49 | 64362674 |
Hypercreatinaemia | 14.02 | 12.49 | 8 | 136001 | 251 | 64362472 |
Cerebral vasoconstriction | 14 | 12.49 | 15 | 135994 | 1207 | 64361516 |
Xerophthalmia | 13.99 | 12.49 | 10 | 135999 | 466 | 64362257 |
Acute cutaneous lupus erythematosus | 13.97 | 12.49 | 9 | 136000 | 353 | 64362370 |
Cerebrovascular accident | 13.95 | 12.49 | 205 | 135804 | 137378 | 64225345 |
Capillary leak syndrome | 13.95 | 12.49 | 25 | 135984 | 3272 | 64359451 |
Portal vein dilatation | 13.94 | 12.49 | 5 | 136004 | 50 | 64362673 |
Peritoneal haematoma | 13.93 | 12.49 | 7 | 136002 | 169 | 64362554 |
Hypertensive encephalopathy | 13.91 | 12.49 | 13 | 135996 | 887 | 64361836 |
Intercepted product administration error | 13.86 | 12.49 | 7 | 136002 | 171 | 64362552 |
Electrolyte imbalance | 13.85 | 12.49 | 96 | 135913 | 25147 | 64337576 |
Dementia | 13.83 | 12.49 | 14 | 135995 | 20752 | 64341971 |
Muscle rigidity | 13.81 | 12.49 | 10 | 135999 | 17463 | 64345260 |
Eye swelling | 13.75 | 12.49 | 16 | 135993 | 22265 | 64340458 |
Eastern Cooperative Oncology Group performance status worsened | 13.74 | 12.49 | 15 | 135994 | 1233 | 64361490 |
Catheter site extravasation | 13.70 | 12.49 | 9 | 136000 | 365 | 64362358 |
Tendon rupture | 13.63 | 12.49 | 3 | 136006 | 10764 | 64351959 |
Head discomfort | 13.63 | 12.49 | 4 | 136005 | 11830 | 64350893 |
Colorectal cancer recurrent | 13.59 | 12.49 | 5 | 136004 | 54 | 64362669 |
Hepatitis B DNA increased | 13.58 | 12.49 | 11 | 135998 | 619 | 64362104 |
Prostate cancer | 13.58 | 12.49 | 13 | 135996 | 19782 | 64342941 |
Obstruction gastric | 13.57 | 12.49 | 16 | 135993 | 1430 | 64361293 |
Hip arthroplasty | 13.54 | 12.49 | 15 | 135994 | 21336 | 64341387 |
Left ventricular dilatation | 13.53 | 12.49 | 13 | 135996 | 919 | 64361804 |
Diabetes mellitus inadequate control | 13.50 | 12.49 | 15 | 135994 | 21306 | 64341417 |
Gastrointestinal fistula | 13.47 | 12.49 | 11 | 135998 | 626 | 64362097 |
Bronchial fistula | 13.46 | 12.49 | 7 | 136002 | 182 | 64362541 |
Procedural pain | 13.44 | 12.49 | 8 | 136001 | 15500 | 64347223 |
Tooth infection | 13.42 | 12.49 | 7 | 136002 | 14594 | 64348129 |
Lhermitte's sign | 13.42 | 12.49 | 3 | 136006 | 3 | 64362720 |
Thrombotic microangiopathy | 13.41 | 12.49 | 70 | 135939 | 16585 | 64346138 |
Dystonia | 13.40 | 12.49 | 12 | 135997 | 18853 | 64343870 |
Pseudomembranous colitis | 13.33 | 12.49 | 31 | 135978 | 4885 | 64357838 |
Mania | 13.29 | 12.49 | 9 | 136000 | 16277 | 64346446 |
Purulent pericarditis | 13.27 | 12.49 | 5 | 136004 | 58 | 64362665 |
Iatrogenic infection | 13.27 | 12.49 | 5 | 136004 | 58 | 64362665 |
Respiratory depression | 13.25 | 12.49 | 18 | 135991 | 23425 | 64339298 |
Sudden death | 13.22 | 12.49 | 80 | 135929 | 20016 | 64342707 |
Rectal cancer recurrent | 13.21 | 12.49 | 4 | 136005 | 22 | 64362701 |
Malignant pleural effusion | 13.20 | 12.49 | 23 | 135986 | 2944 | 64359779 |
Catheter site thrombosis | 13.19 | 12.49 | 7 | 136002 | 190 | 64362533 |
Systemic scleroderma | 13.17 | 12.49 | 13 | 135996 | 950 | 64361773 |
Wrong rate | 13.12 | 12.49 | 5 | 136004 | 60 | 64362663 |
Bladder tamponade | 13.08 | 12.49 | 10 | 135999 | 517 | 64362206 |
Red blood cell nucleated morphology present | 13.07 | 12.49 | 4 | 136005 | 23 | 64362700 |
Diverticulitis | 13.00 | 12.49 | 40 | 135969 | 38578 | 64324145 |
Product administration error | 13.00 | 12.49 | 24 | 135985 | 27619 | 64335104 |
Hypertrichosis | 12.99 | 12.49 | 14 | 135995 | 1134 | 64361589 |
Oesophageal squamous cell carcinoma metastatic | 12.96 | 12.49 | 3 | 136006 | 4 | 64362719 |
Pulmonary hypertension | 12.94 | 12.49 | 47 | 135962 | 43092 | 64319631 |
Tracheal stenosis | 12.93 | 12.49 | 8 | 136001 | 292 | 64362431 |
Procedural vomiting | 12.93 | 12.49 | 11 | 135998 | 663 | 64362060 |
Pleural fistula | 12.92 | 12.49 | 4 | 136005 | 24 | 64362699 |
Carbohydrate antigen 15-3 increased | 12.90 | 12.49 | 13 | 135996 | 974 | 64361749 |
Pulmonary congestion | 12.84 | 12.49 | 19 | 135990 | 23861 | 64338862 |
Rectal adenocarcinoma | 12.84 | 12.49 | 15 | 135994 | 1328 | 64361395 |
Hepatic vein stenosis | 12.83 | 12.49 | 5 | 136004 | 64 | 64362659 |
Blood pressure decreased | 12.80 | 12.49 | 118 | 135891 | 86081 | 64276642 |
Ovarian failure | 12.78 | 12.49 | 10 | 135999 | 535 | 64362188 |
Neutrophilia | 12.77 | 12.49 | 37 | 135972 | 6657 | 64356066 |
Duodenal stenosis | 12.74 | 12.49 | 11 | 135998 | 677 | 64362046 |
Blood pressure diastolic decreased | 12.73 | 12.49 | 17 | 135992 | 22284 | 64340439 |
Blood potassium increased | 12.72 | 12.49 | 22 | 135987 | 25958 | 64336765 |
Fixed eruption | 12.70 | 12.49 | 19 | 135990 | 2140 | 64360583 |
Cardiogenic shock | 12.66 | 12.49 | 114 | 135895 | 32313 | 64330410 |
Diverticulum | 12.63 | 12.49 | 6 | 136003 | 13192 | 64349531 |
Rectal abscess | 12.62 | 12.49 | 16 | 135993 | 1541 | 64361182 |
Pollakiuria | 12.62 | 12.49 | 30 | 135979 | 31500 | 64331223 |
Angina pectoris | 12.59 | 12.49 | 148 | 135861 | 44933 | 64317790 |
Stress ulcer | 12.57 | 12.49 | 6 | 136003 | 129 | 64362594 |
Cutaneous tuberculosis | 12.55 | 12.49 | 7 | 136002 | 210 | 64362513 |
Renal hydrocele | 12.52 | 12.49 | 4 | 136005 | 27 | 64362696 |
None
Source | Code | Description |
---|---|---|
ATC | L01BC02 | ANTINEOPLASTIC AND IMMUNOMODULATING AGENTS ANTINEOPLASTIC AGENTS ANTIMETABOLITES Pyrimidine analogues |
ATC | L01BC52 | ANTINEOPLASTIC AND IMMUNOMODULATING AGENTS ANTINEOPLASTIC AGENTS ANTIMETABOLITES Pyrimidine analogues |
FDA MoA | N0000000233 | Nucleic Acid Synthesis Inhibitors |
FDA EPC | N0000175595 | Nucleoside Metabolic Inhibitor |
MeSH PA | D000963 | Antimetabolites |
MeSH PA | D000964 | Antimetabolites, Antineoplastic |
MeSH PA | D000970 | Antineoplastic Agents |
MeSH PA | D007155 | Immunologic Factors |
MeSH PA | D007166 | Immunosuppressive Agents |
MeSH PA | D009676 | Noxae |
CHEBI has role | CHEBI:35221 | antimetabolite |
CHEBI has role | CHEBI:35610 | antineoplastic agents |
CHEBI has role | CHEBI:35703 | Xenobiotic |
CHEBI has role | CHEBI:35705 | immunosuppressive agents |
CHEBI has role | CHEBI:78298 | environmental contaminants |
CHEBI has role | CHEBI:132992 | radiosensitizing agents |
CHEBI has role | CHEBI:25435 | mutagens |
CHEBI has role | CHEBI:77746 | Homo sapiens metabolite |
Disease | Relation | SNOMED_ID | DOID |
---|---|---|---|
Actinic keratosis | indication | 201101007 | DOID:8866 |
Metastasis from malignant tumor of colon | indication | 314998002 | |
Malignant tumor of stomach | indication | 363349007 | DOID:10534 |
Malignant tumor of colon | indication | 363406005 | DOID:219 |
Small intestine cancer | indication | 363509000 | DOID:10154 |
Superficial basal cell carcinoma | indication | 403914000 | |
Adenocarcinoma of pancreas | indication | 700423003 | DOID:4074 |
Metastatic Breast Carcinoma | indication | ||
Carcinoid syndrome | off-label use | 35868009 | |
Actinic cheilitis | off-label use | 46795000 | |
Radiation dermatitis | off-label use | 49084001 | |
Neoplasm of glans penis | off-label use | 126898002 | |
Carcinoma of breast | off-label use | 254838004 | DOID:3459 |
Malignant tumor of head and/or neck | off-label use | 255056009 | |
Malignant tumor of cervix | off-label use | 363354003 | DOID:4362 |
Malignant tumor of esophagus | off-label use | 363402007 | |
Malignant tumor of anus | off-label use | 363490009 | DOID:14110 |
Malignant tumor of urinary bladder | off-label use | 399326009 | DOID:11054 |
Leukoplakia of oral mucosa | off-label use | 414603003 | |
Pancreatic Neuroendocrine Tumor | off-label use | 717919005 | |
Biliary Tract Malignancy | off-label use | ||
Metastatic Malignant Tumor of Anus | off-label use | ||
Nutritional disorder | contraindication | 2492009 | DOID:374 |
Acute vomiting | contraindication | 23971007 | |
Stomatitis | contraindication | 61170000 | DOID:9637 |
Diarrhea | contraindication | 62315008 | |
Acute infectious disease | contraindication | 63171007 | |
Gastrointestinal hemorrhage | contraindication | 74474003 | |
Dihydrouracil dehydrogenase (NADP^+^) deficiency | contraindication | 77365006 | DOID:14218 |
Leukopenia | contraindication | 84828003 | DOID:615 |
Kidney disease | contraindication | 90708001 | DOID:557 |
Superficial ulcer of skin | contraindication | 93448009 | |
Secondary malignant neoplasm of bone marrow | contraindication | 94217008 | |
Bleeding | contraindication | 131148009 | |
Angina pectoris | contraindication | 194828000 | |
Disease of liver | contraindication | 235856003 | DOID:409 |
Pregnancy, function | contraindication | 289908002 | |
Thrombocytopenic disorder | contraindication | 302215000 | DOID:1588 |
Neutropenic disorder | contraindication | 303011007 | DOID:1227 |
Bone marrow depression | contraindication | 307762000 | |
Pharyngitis | contraindication | 405737000 | DOID:2275 |
Breastfeeding (mother) | contraindication | 413712001 | |
Palmar-Plantar Erythrodysesthesia | contraindication |
None
None
Dissociation level | Dissociation constant | Type (acidic/basic) |
---|---|---|
pKa1 | 8.02 | acidic |
None
None
Target | Class | Pharos | UniProt | Action | Type | Activity value (-log[M]) | Mechanism action | Bioact source | MoA source |
---|---|---|---|---|---|---|---|---|---|
Thymidylate synthase | Enzyme | INHIBITOR | WOMBAT-PK | CHEMBL | |||||
Multidrug resistance-associated protein 5 | Transporter | WOMBAT-PK | |||||||
ATP-binding cassette sub-family C member 11 | Transporter | WOMBAT-PK | |||||||
Thymidylate synthase | Enzyme | IC50 | 7.70 | CHEMBL | |||||
Uracil phosphoribosyltransferase | Enzyme | Ki | 4.89 | CHEMBL |
ID | Source |
---|---|
4017806 | VUID |
N0000146166 | NUI |
D00584 | KEGG_DRUG |
202632 | RXNORM |
C0016360 | UMLSCUI |
CHEBI:46345 | CHEBI |
URF | PDB_CHEM_ID |
CHEMBL185 | ChEMBL_ID |
D005472 | MESH_DESCRIPTOR_UI |
DB00544 | DRUGBANK_ID |
4789 | IUPHAR_LIGAND_ID |
1421 | INN_ID |
U3P01618RT | UNII |
3385 | PUBCHEM_CID |
4694 | MMSL |
4745 | MMSL |
6969 | MMSL |
d00235 | MMSL |
002646 | NDDF |
4017806 | VANDF |
3127006 | SNOMEDCT_US |
387172005 | SNOMEDCT_US |
Product | Category | Ingredients | NDC | Form | Quantity | Route | Marketing | Label |
---|---|---|---|---|---|---|---|---|
Efudex | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0187-3202 | SOLUTION | 0.50 g | TOPICAL | NDA | 2 sections |
Efudex | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0187-3203 | SOLUTION | 1.25 g | TOPICAL | NDA | 2 sections |
Efudex | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0187-3204 | CREAM | 2 g | TOPICAL | NDA | 2 sections |
Carac | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0187-5200 | CREAM | 5 mg | TOPICAL | NDA | 24 sections |
Fluorouracil | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0378-4791 | CREAM | 5 mg | TOPICAL | NDA authorized generic | 19 sections |
Fluorouracil Cream | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0378-8078 | CREAM | 5 mg | TOPICAL | NDA authorized generic | 22 sections |
Fluoroplex | HUMAN PRESCRIPTION DRUG LABEL | 1 | 16110-812 | CREAM | 10 mg | TOPICAL | NDA | 23 sections |
Fluoroplex | HUMAN PRESCRIPTION DRUG LABEL | 1 | 16110-812 | CREAM | 10 mg | TOPICAL | NDA | 23 sections |
Fluorouracil | HUMAN PRESCRIPTION DRUG LABEL | 1 | 16714-178 | CREAM | 50 mg | TOPICAL | ANDA | 20 sections |
Fluorouracil | HUMAN PRESCRIPTION DRUG LABEL | 1 | 16729-276 | INJECTION, SOLUTION | 50 mg | INTRAVENOUS | ANDA | 24 sections |
Fluorouracil | HUMAN PRESCRIPTION DRUG LABEL | 1 | 16729-276 | INJECTION, SOLUTION | 50 mg | INTRAVENOUS | ANDA | 24 sections |
Fluorouracil | HUMAN PRESCRIPTION DRUG LABEL | 1 | 16729-542 | CREAM | 50 mg | TOPICAL | ANDA | 19 sections |
Fluorouracil | HUMAN PRESCRIPTION DRUG LABEL | 1 | 16729-542 | CREAM | 50 mg | TOPICAL | ANDA | 19 sections |
FLUOROURACIL | HUMAN PRESCRIPTION DRUG LABEL | 1 | 21695-829 | CREAM | 50 mg | TOPICAL | ANDA | 18 sections |
fluorouracil | HUMAN PRESCRIPTION DRUG LABEL | 1 | 25021-215 | INJECTION, SOLUTION | 50 mg | INTRAVENOUS | ANDA | 26 sections |
TOLAK | HUMAN PRESCRIPTION DRUG LABEL | 1 | 28105-421 | CREAM | 0.04 g | TOPICAL | NDA | 26 sections |
Fluorouracil | HUMAN PRESCRIPTION DRUG LABEL | 1 | 50090-4264 | CREAM | 50 mg | TOPICAL | ANDA | 20 sections |
Fluorouracil | HUMAN PRESCRIPTION DRUG LABEL | 1 | 51672-4062 | SOLUTION | 20 mg | TOPICAL | ANDA | 21 sections |
Fluorouracil | HUMAN PRESCRIPTION DRUG LABEL | 1 | 51672-4063 | SOLUTION | 50 mg | TOPICAL | ANDA | 21 sections |
Fluorouracil | HUMAN PRESCRIPTION DRUG LABEL | 1 | 51672-4118 | CREAM | 50 mg | TOPICAL | ANDA | 20 sections |
FLUOROURACIL | HUMAN PRESCRIPTION DRUG LABEL | 1 | 51862-362 | CREAM | 50 mg | TOPICAL | ANDA | 20 sections |
Fluorouracil | HUMAN PRESCRIPTION DRUG LABEL | 1 | 52549-4118 | CREAM | 50 mg | TOPICAL | ANDA | 21 sections |
FLUOROURACIL | Human Prescription Drug Label | 1 | 54868-6293 | CREAM | 50 mg | TOPICAL | ANDA | 18 sections |
Fluorouracil | Human Prescription Drug Label | 1 | 63323-117 | INJECTION, SOLUTION | 50 mg | INTRAVENOUS | ANDA | 25 sections |
Fluorouracil | Human Prescription Drug Label | 1 | 63323-117 | INJECTION, SOLUTION | 50 mg | INTRAVENOUS | ANDA | 25 sections |
Fluorouracil | Human Prescription Drug Label | 1 | 63323-117 | INJECTION, SOLUTION | 50 mg | INTRAVENOUS | ANDA | 25 sections |
Fluorouracil | Human Prescription Drug Label | 1 | 63323-117 | INJECTION, SOLUTION | 50 mg | INTRAVENOUS | ANDA | 25 sections |
Fluorouracil | Human Prescription Drug Label | 1 | 63323-117 | INJECTION, SOLUTION | 50 mg | INTRAVENOUS | ANDA | 25 sections |
Fluorouracil | Human Prescription Drug Label | 1 | 63323-117 | INJECTION, SOLUTION | 50 mg | INTRAVENOUS | ANDA | 25 sections |
FLUOROURACIL | Human Prescription Drug Label | 1 | 66530-249 | CREAM | 50 mg | TOPICAL | ANDA | 18 sections |