capecitabine 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | PK/Tox | Related Drugs | BioActivity |

Stem definitionDrug idCAS RN
nucleosides antiviral or antineoplastic agents, cytarabine or azacitidine derivatives 480 154361-50-9

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • capecitabine
  • capecitibine
  • capecytabine
  • capiibine
  • captabin
  • xeloda
A deoxycytidine derivative and fluorouracil PRODRUG that is used as an ANTINEOPLASTIC ANTIMETABOLITE in the treatment of COLON CANCER; BREAST CANCER and GASTRIC CANCER.
  • Molecular weight: 359.35
  • Formula: C15H22FN3O6
  • CLOGP: 0.84
  • LIPINSKI: 0
  • HAC: 9
  • HDO: 3
  • TPSA: 120.69
  • ALOGS: -3.16
  • ROTB: 7
  • Status: OFP
    • Legend:
    OFP - off patent
    OFM - off market
    ONP - on patent

Drug dosage:

None

ADMET properties:

PropertyValueReference
BDDCS (Biopharmaceutical Drug Disposition Classification System) 1 Benet LZ, Broccatelli F, Oprea TI
S (Water solubility) 26 mg/mL Benet LZ, Broccatelli F, Oprea TI
EoM (Fraction excreted unchanged in urine) 3 % Benet LZ, Broccatelli F, Oprea TI
MRTD (Maximum Recommended Therapeutic Daily Dose) 171.93 µM/kg/day Contrera JF, Matthews EJ, Kruhlak NL, Benz RD
BA (Bioavailability) 99 % Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H

Predicted pharmacokinetic/toxicological properties (PK-AZ):

PropertyDescriptionValueUnitConfidenceSimilarity
azlogd74 LogD at pH 7.4 1.242 High 1
caco2-efflux Caco-2 efflux ratio (BA/AB) 10.471 High 1
caco2-intrinsic-papp Caco-2 intrinsic apparent permeability 16.982 10^-6 cm/s High 1
dh-clint Dog hepatocyte intrinsic clearance 6.442 uL/min/10^6 cells High 1
dppb Dog plasma protein binding (% unbound) 57.150 % High 1
fcs-ppb Fetal calf serum protein binding (% unbound) 66.610 % High 1
herg hERG pIC50 4.322 pIC50 High 1
hh-clint Human hepatocyte intrinsic clearance 3.475 uL/min/10^6 cells High 1
hlm-clint Human liver microsomal intrinsic clearance 5.715 uL/min/mg protein High 1
hppb Human plasma protein binding (% unbound) 45.520 % High 1
kinase-safety-class ACVR2B,CDK5,EIF2AK3,GRK2,PDK1,PDK2,PRKDC 7
kinase-selectivity-class MAP2K6,PDK1 2
mdck-mdr1-bcrp-efflux MDCK-MDR1-BCRP efflux ratio 6.310 High 1
mdck-mdr1-efflux MDCK-MDR1 efflux ratio 13.243 High 1
mh-clint Mouse hepatocyte intrinsic clearance 15.812 High 1
mppb Mouse plasma protein binding (% unbound) 45.410 High 1
nih-mdck-mdr1-efflux NIH MDCK-MDR1 efflux ratio 7.534 High 1
pfas-class PFAS structural alert (1 = True, 0 = False) 0
pppb Pig plasma protein binding (% unbound) 55.730 % High 1
rat-kpuu-brain Rat brain Kpuu 0.089 % High 1
rh-clint Rat hepatocyte intrinsic clearance 17.742 uL/min/10^6 cells High 1
rh-fuinc Rat hepatocyte fraction unbound in incubation 91.120 % High 1
rppb Rat plasma protein binding (% unbound) 29.900 % High 1
solubility-dd Solubility at pH 7.4 in DMSO 781.628 uM High 1

Approvals:

DateAgencyCompanyOrphan
April 16, 2003 PMDA CHUGAI PHARMACEUTICAL CO., LTD.
April 30, 1998 FDA HOFFMANN LA ROCHE
Nov. 19, 2012 EMA medac Gesellschaft für klinische Spezialpräparate mbH

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Palmar-plantar erythrodysaesthesia syndrome 9295.67 13.91 2857 131779 25166 90468645
Disease progression 4701.08 13.91 2910 131726 153705 90340106
Malignant neoplasm progression 3443.78 13.91 2080 132556 104790 90389021
Diarrhoea 3176.26 13.91 5263 129373 933927 89559884
Metastases to liver 2059.55 13.91 956 133680 27851 90465960
Metastases to bone 1778.41 13.91 832 133804 24673 90469138
Death 1485.12 13.91 2525 132111 454026 90039785
Metastases to central nervous system 1359.67 13.91 616 134020 16926 90476885
Mucosal inflammation 1340.95 13.91 915 133721 56710 90437101
Metastases to lung 1081.66 13.91 511 134125 15480 90478331
Neoplasm progression 960.99 13.91 675 133961 43811 90450000
Breast cancer metastatic 936.67 13.91 455 134181 14677 90479134
Neuropathy peripheral 796.43 13.91 999 133637 135971 90357840
Neutropenia 768.58 13.91 1274 133362 223630 90270181
Myelosuppression 666.30 13.91 587 134049 53004 90440807
Dehydration 631.48 13.91 1077 133559 193370 90300441
Metastases to lymph nodes 589.63 13.91 306 134330 11383 90482428
Vomiting 564.45 13.91 2488 132148 785805 89708006
Arteriospasm coronary 558.11 13.91 228 134408 4822 90488989
Nausea 536.68 13.91 3136 131500 1107180 89386631
Rheumatoid arthritis 521.19 13.91 3 134633 362611 90131200
Joint swelling 506.55 13.91 73 134563 503227 89990584
Systemic lupus erythematosus 492.86 13.91 9 134627 361887 90131924
Contraindicated product administered 427.78 13.91 10 134626 320129 90173682
Thrombocytopenia 421.89 13.91 947 133689 207778 90286033
Neurotoxicity 420.38 13.91 307 134329 21160 90472651
Arthropathy 419.57 13.91 33 134603 366209 90127602
Maternal exposure during pregnancy 419.43 13.91 30 134606 360033 90133778
Glossodynia 395.33 13.91 20 134616 321759 90172052
Gastrointestinal toxicity 388.25 13.91 216 134420 9251 90484560
Metastases to skin 363.10 13.91 132 134504 2008 90491803
Skin fissures 357.17 13.91 275 134361 20534 90473277
Bone marrow failure 355.28 13.91 330 134306 31891 90461920
Enteritis 355.07 13.91 210 134426 10111 90483700
Arthralgia 342.62 13.91 392 134244 778130 89715681
Paronychia 334.71 13.91 185 134451 7821 90485990
Skin exfoliation 324.19 13.91 450 134186 67463 90426348
Wound 323.81 13.91 36 134600 302944 90190867
Helicobacter infection 320.26 13.91 3 134633 226847 90266964
Condition aggravated 317.75 13.91 252 134384 595293 89898518
Cardiotoxicity 315.97 13.91 202 134434 11187 90482624
Breast cancer 315.06 13.91 394 134242 53367 90440444
Osteonecrosis of jaw 313.85 13.91 337 134299 38766 90455045
Skin toxicity 312.16 13.91 167 134469 6612 90487199
Tumour marker increased 310.13 13.91 158 134478 5649 90488162
Metastasis 307.61 13.91 160 134476 5977 90487834
Pericarditis 304.70 13.91 26 134610 270125 90223686
Duodenal ulcer perforation 299.11 13.91 6 134630 221282 90272529
Ascites 297.69 13.91 361 134275 47379 90446432
Drug hypersensitivity 291.86 13.91 163 134473 463446 90030365
Therapeutic product effect decreased 286.67 13.91 37 134599 277534 90216277
Pleural effusion 284.20 13.91 558 134078 111433 90382378
Irritable bowel syndrome 282.92 13.91 5 134631 207443 90286368
Sinusitis 273.11 13.91 85 134551 343003 90150808
Fibromyalgia 269.60 13.91 8 134628 206261 90287550
Exposure during pregnancy 268.70 13.91 23 134613 238387 90255424
Ejection fraction decreased 264.86 13.91 256 134380 25997 90467814
Asthenia 262.71 13.91 1518 133118 532233 89961578
Decreased appetite 260.12 13.91 1178 133458 375362 90118449
Metastases to pleura 259.53 13.91 102 134534 1942 90491869
Haematotoxicity 253.91 13.91 183 134453 12352 90481459
Laryngospasm 251.70 13.91 115 134521 3218 90490593
Swelling 251.46 13.91 156 134480 418902 90074909
Folliculitis 243.78 13.91 15 134621 204338 90289473
Drug ineffective 241.75 13.91 1149 133487 1383149 89110662
Treatment failure 235.32 13.91 79 134557 303849 90189962
Musculoskeletal stiffness 231.47 13.91 76 134560 296456 90197355
Dihydropyrimidine dehydrogenase deficiency 230.38 13.91 50 134586 74 90493737
Hyperbilirubinaemia 227.92 13.91 179 134457 13757 90480054
PIK3CA-activated mutation 225.86 13.91 80 134556 1124 90492687
Infusion related reaction 222.51 13.91 176 134460 416604 90077207
Enterocolitis 221.33 13.91 157 134479 10333 90483478
Blood bilirubin increased 219.43 13.91 296 134340 43174 90450637
Lower respiratory tract infection 216.43 13.91 53 134583 250606 90243205
Mobility decreased 214.58 13.91 54 134582 250680 90243131
Therapy cessation 213.84 13.91 267 134369 36094 90457717
Skin discolouration 213.48 13.91 295 134341 44020 90449791
Discomfort 211.16 13.91 72 134564 274263 90219548
Metastases to peritoneum 207.31 13.91 108 134528 4047 90489764
Abdominal discomfort 206.68 13.91 243 134393 477085 90016726
Product use issue 204.61 13.91 118 134518 329801 90164010
Weight increased 204.22 13.91 192 134444 417735 90076076
Dry skin 202.16 13.91 421 134215 87652 90406159
Urticaria 200.96 13.91 107 134529 312627 90181184
Wheezing 196.66 13.91 55 134581 238025 90255786
Hepatic function abnormal 196.31 13.91 290 134346 45998 90447813
Type 2 diabetes mellitus 196.15 13.91 33 134603 203211 90290600
Psoriasis 195.76 13.91 5 134631 147749 90346062
Asthma 194.42 13.91 59 134577 242101 90251710
Metastatic neoplasm 192.37 13.91 108 134528 4707 90489104
Completed suicide 191.84 13.91 5 134631 145053 90348758
Osteoarthritis 188.40 13.91 32 134604 195698 90298113
Breast cancer recurrent 186.75 13.91 111 134525 5392 90488419
Pseudocirrhosis 181.94 13.91 64 134572 880 90492931
Injury 181.92 13.91 36 134600 197313 90296498
Hepatic enzyme increased 175.87 13.91 166 134470 360570 90133241
Blood cholesterol increased 175.66 13.91 46 134590 207966 90285845
Pruritus 173.33 13.91 339 134297 541186 89952625
Stomatitis 173.03 13.91 837 133799 273861 90219950
Osteonecrosis 172.70 13.91 204 134432 26037 90467774
Hospice care 172.56 13.91 131 134505 9573 90484238
Metastases to spine 171.75 13.91 92 134544 3651 90490160
Nasopharyngitis 171.12 13.91 212 134424 406892 90086919
Hypokalaemia 167.44 13.91 501 134135 130615 90363196
Therapy partial responder 163.00 13.91 182 134454 21861 90471950
Joint range of motion decreased 158.66 13.91 11 134625 135632 90358179
Metastases to meninges 158.03 13.91 87 134549 3648 90490163
Depression 150.43 13.91 135 134501 300466 90193345
Hypersensitivity 148.59 13.91 281 134355 454396 90039415
Pain 147.62 13.91 873 133763 995468 89498343
Leukopenia 147.17 13.91 404 134232 100306 90393505
Arthritis 147.09 13.91 34 134602 167281 90326530
Carcinoembryonic antigen increased 143.39 13.91 70 134566 2280 90491531
Lymphangiosis carcinomatosa 143.20 13.91 63 134573 1609 90492202
Polyneuropathy 138.41 13.91 157 134479 19184 90474627
Bursitis 137.17 13.91 17 134619 131637 90362174
Hepatic lesion 136.36 13.91 92 134544 5581 90488230
Carbohydrate antigen 15-3 increased 135.25 13.91 64 134572 1943 90491868
Hepatic failure 135.23 13.91 225 134411 39503 90454308
Intestinal obstruction 134.10 13.91 216 134420 36915 90456896
Platelet count decreased 134.00 13.91 478 134158 136491 90357320
Onycholysis 131.81 13.91 65 134571 2165 90491646
Migraine 131.56 13.91 59 134577 190333 90303478
Prescribed overdose 130.47 13.91 3 134633 97622 90396189
Jaundice 128.30 13.91 197 134439 32320 90461491
Fall 126.97 13.91 335 134301 481475 90012336
Dysaesthesia pharynx 126.14 13.91 34 134602 174 90493637
Headache 126.04 13.91 759 133877 861987 89631824
Obesity 119.30 13.91 10 134626 105497 90388314
Colitis 117.92 13.91 296 134340 69646 90424165
Lip dry 110.31 13.91 11 134625 100944 90392867
Alopecia 109.72 13.91 373 134263 494698 89999113
Bone pain 107.31 13.91 265 134371 61718 90432093
Non-cirrhotic portal hypertension 105.91 13.91 34 134602 346 90493465
Pulmonary embolism 104.45 13.91 428 134208 130392 90363419
Bone lesion 103.79 13.91 82 134554 6355 90487456
Sciatica 103.42 13.91 14 134622 101368 90392443
Metastases to the mediastinum 102.13 13.91 38 134598 619 90493192
Contusion 100.12 13.91 136 134500 251080 90242731
Sleep disorder 98.94 13.91 89 134547 197941 90295870
Hypercholesterolaemia 95.95 13.91 17 134619 100875 90392936
Wound infection 94.75 13.91 21 134615 106381 90387430
Injection site pain 94.27 13.91 72 134564 173627 90320184
Febrile neutropenia 94.24 13.91 475 134161 157874 90335937
Metastases to chest wall 94.12 13.91 36 134600 635 90493176
Metastases to adrenals 94.07 13.91 40 134596 938 90492873
Autoimmune disorder 93.42 13.91 5 134631 76739 90417072
Intentional overdose 93.28 13.91 14 134622 93820 90399991
Bronchitis 92.87 13.91 56 134580 152871 90340940
Confusional state 92.48 13.91 281 134355 385924 90107887
Prescribed underdose 90.97 13.91 5 134631 75014 90418797
Pneumonitis 90.82 13.91 202 134434 43968 90449843
Hypoalbuminaemia 90.69 13.91 115 134521 15782 90478029
Recurrent cancer 89.76 13.91 52 134584 2407 90491404
Peripheral swelling 89.62 13.91 314 134322 412792 90081019
Bone disorder 88.31 13.91 138 134498 22982 90470829
Neoplasm malignant 87.30 13.91 170 134466 33710 90460101
Portal hypertension 87.00 13.91 65 134571 4636 90489175
Loss of personal independence in daily activities 86.71 13.91 47 134589 136058 90357753
Overdose 86.06 13.91 65 134571 157644 90336167
Influenza 85.97 13.91 50 134586 139214 90354597
Ileus 85.51 13.91 114 134522 16432 90477379
Skin hyperpigmentation 84.99 13.91 75 134561 6776 90487035
Insomnia 83.91 13.91 237 134399 333237 90160574
Pneumonia 83.49 13.91 580 134056 637479 89856332
Adverse event 83.29 13.91 35 134601 117383 90376428
Grip strength decreased 82.98 13.91 18 134618 92558 90401253
Fingerprint loss 82.79 13.91 18 134618 27 90493784
Anaemia 82.61 13.91 844 133792 351958 90141853
Therapeutic product effect incomplete 82.38 13.91 100 134536 193796 90300015
Impaired healing 81.55 13.91 139 134497 234060 90259751
Stridor 81.48 13.91 63 134573 4730 90489081
Inflammation 81.43 13.91 87 134549 178505 90315306
Product use in unapproved indication 80.22 13.91 245 134391 335991 90157820
Subacute cutaneous lupus erythematosus 78.79 13.91 55 134581 3527 90490284
Ear infection 77.83 13.91 7 134629 69768 90424043
Abdominal lymphadenopathy 76.58 13.91 35 134601 980 90492831
Night sweats 75.63 13.91 49 134587 128717 90365094
Drug intolerance 75.46 13.91 375 134261 447216 90046595
Osteoporosis 74.79 13.91 25 134611 96506 90397305
Peripheral sensory neuropathy 74.69 13.91 80 134556 9170 90484641
Drug interaction 74.42 13.91 190 134446 276263 90217548
Neutrophil count decreased 73.68 13.91 254 134382 71278 90422533
Infusion site coldness 73.67 13.91 23 134613 212 90493599
Hypovolaemic shock 73.09 13.91 70 134566 7024 90486787
Pericardial effusion 72.99 13.91 166 134470 36667 90457144
Congestive cardiomyopathy 72.82 13.91 71 134565 7283 90486528
White blood cell count decreased 72.76 13.91 461 134175 166648 90327163
Constipation 72.05 13.91 684 133952 279711 90214100
Pulmonary fibrosis 71.63 13.91 35 134601 107468 90386343
Gastrointestinal perforation 71.60 13.91 56 134580 4276 90489535
Epistaxis 71.51 13.91 283 134353 84842 90408969
Liver injury 71.37 13.91 89 134547 170478 90323333
Lymphadenopathy 70.22 13.91 187 134449 45588 90448223
Blepharospasm 69.45 13.91 3 134633 55442 90438369
Nodular regenerative hyperplasia 69.25 13.91 29 134607 654 90493157
Intestinal perforation 69.24 13.91 94 134542 13787 90480024
Therapy change 69.01 13.91 73 134563 8249 90485562
Fatigue 68.33 13.91 2217 132419 1151806 89342005
Abdominal pain 68.14 13.91 892 133744 394829 90098982
Paraesthesia 68.00 13.91 618 134018 249708 90244103
Suicide attempt 66.89 13.91 15 134621 75384 90418427
Foot deformity 66.49 13.91 6 134630 59645 90434166
Product quality issue 66.06 13.91 18 134618 79307 90414504
Mucosal toxicity 65.24 13.91 24 134612 378 90493433
Hypertriglyceridaemia 65.06 13.91 69 134567 7820 90485991
Bradycardia 64.46 13.91 22 134614 83825 90409986
Mouth ulceration 64.07 13.91 166 134470 39808 90454003
Gamma-glutamyltransferase decreased 63.99 13.91 23 134613 338 90493473
Lung disorder 63.98 13.91 77 134559 149806 90344005
Suicidal ideation 62.95 13.91 16 134620 73839 90419972
Disseminated intravascular coagulation 62.87 13.91 114 134522 21424 90472387
Tooth extraction 62.09 13.91 81 134555 11432 90482379
Road traffic accident 61.79 13.91 42 134594 107584 90386227
Performance status decreased 61.55 13.91 51 134585 4229 90489582
Intentional product misuse 61.50 13.91 28 134608 89576 90404235
Dysphagia 61.38 13.91 329 134307 111949 90381862
Central nervous system lesion 61.35 13.91 81 134555 11565 90482246
Brain oedema 61.22 13.91 100 134536 17285 90476526
Lymphoedema 60.95 13.91 88 134548 13665 90480146
Delirium 60.89 13.91 40 134596 104319 90389492
Nasal congestion 60.56 13.91 24 134612 83390 90410421
Device related thrombosis 60.24 13.91 38 134598 2055 90491756
Infection 60.07 13.91 305 134331 361789 90132022
Thrombosis 59.50 13.91 241 134395 73010 90420801
Sepsis 59.47 13.91 464 134172 179350 90314461
Memory impairment 59.11 13.91 128 134508 197116 90296695
Product dose omission issue 59.07 13.91 228 134408 291459 90202352
Abortion spontaneous 58.76 13.91 6 134630 54050 90439761
Neoplasm recurrence 57.95 13.91 44 134592 3215 90490596
Leukoencephalopathy 57.78 13.91 52 134584 4821 90488990
Bone erosion 57.34 13.91 6 134630 53015 90440796
Erythema 57.27 13.91 556 134080 228690 90265121
Disease recurrence 56.92 13.91 153 134483 37500 90456311
Therapy interrupted 56.09 13.91 183 134453 49925 90443886
Musculoskeletal pain 55.69 13.91 106 134530 171145 90322666
X-ray abnormal 55.16 13.91 3 134633 45421 90448390
Varices oesophageal 54.28 13.91 45 134591 3734 90490077
Ventricular fibrillation 53.88 13.91 84 134552 13960 90479851
Pregnancy 53.74 13.91 13 134623 62034 90431777
Neoplasm 53.33 13.91 66 134570 8837 90484974
Gait inability 52.75 13.91 85 134551 146371 90347440
Nail discolouration 51.63 13.91 41 134595 3201 90490610
Superior vena cava syndrome 51.32 13.91 24 134612 709 90493102
Pyogenic granuloma 51.15 13.91 19 134617 308 90493503
Metastases to breast 50.97 13.91 20 134616 379 90493432
Recall phenomenon 50.93 13.91 25 134611 824 90492987
Jaw operation 50.33 13.91 25 134611 846 90492965
Debridement 49.85 13.91 28 134608 1221 90492590
Hyperaesthesia 49.67 13.91 70 134566 10632 90483179
Ataxia 49.52 13.91 93 134543 17949 90475862
Injection site erythema 49.50 13.91 44 134592 98458 90395353
Hypophagia 49.35 13.91 141 134495 35796 90458015
Gingival bleeding 48.84 13.91 83 134553 14820 90478991
Tumour pain 48.73 13.91 32 134604 1855 90491956
Plasma cell myeloma 48.65 13.91 3 134633 40825 90452986
Gastrointestinal injury 48.65 13.91 24 134612 800 90493011
Nail infection 48.57 13.91 36 134600 2536 90491275
Anxiety 48.53 13.91 266 134370 309506 90184305
Exostosis 48.29 13.91 10 134626 53124 90440687
Tumour perforation 48.07 13.91 15 134621 138 90493673
Colorectal cancer metastatic 47.97 13.91 24 134612 825 90492986
Acute coronary syndrome 47.65 13.91 69 134567 10744 90483067
Amnesia 47.10 13.91 55 134581 108450 90385361
Nasal mucosal disorder 46.76 13.91 31 134605 1826 90491985
Colon cancer metastatic 46.50 13.91 28 134608 1393 90492418
Pulmonary sarcoidosis 46.17 13.91 27 134609 1272 90492539
Lacrimation increased 46.09 13.91 115 134521 26947 90466864
Bone sequestrum 45.92 13.91 28 134608 1425 90492386
Metastases to abdominal cavity 45.91 13.91 21 134615 589 90493222
Angina bullosa haemorrhagica 45.85 13.91 14 134622 119 90493692
Joint dislocation 45.84 13.91 6 134630 44576 90449235
Cold dysaesthesia 45.60 13.91 10 134626 16 90493795
Metastases to ovary 45.59 13.91 20 134616 507 90493304
Periodontitis 45.45 13.91 41 134595 3812 90489999
Laryngitis 45.21 13.91 10 134626 50743 90443068
Nail bed inflammation 45.19 13.91 30 134606 1771 90492040
Dysaesthesia 45.19 13.91 47 134589 5208 90488603
Hepatopulmonary syndrome 45.03 13.91 13 134623 89 90493722
Chronic obstructive pulmonary disease 44.86 13.91 27 134609 73802 90420009
Anastomotic leak 44.73 13.91 21 134615 626 90493185
Osteolysis 44.31 13.91 39 134597 3511 90490300
Breast disorder 44.08 13.91 35 134601 2732 90491079
Streptococcal sepsis 43.99 13.91 39 134597 3545 90490266
Second primary malignancy 43.96 13.91 65 134571 10313 90483498
Metastases to eye 43.48 13.91 15 134621 194 90493617
Dry mouth 43.23 13.91 135 134501 183924 90309887
Disability 43.07 13.91 5 134631 40740 90453071
Plantar erythema 42.93 13.91 15 134621 202 90493609
C-reactive protein increased 42.63 13.91 133 134503 181256 90312555
Activated PI3 kinase delta syndrome 42.37 13.91 12 134624 76 90493735
Exposed bone in jaw 42.36 13.91 35 134601 2891 90490920
Medication error 42.31 13.91 38 134598 84614 90409197
Radiation skin injury 42.12 13.91 24 134612 1076 90492735
Malignant ascites 42.11 13.91 23 134613 949 90492862
Blood uric acid decreased 42.06 13.91 22 134614 831 90492980
Toxic leukoencephalopathy 42.06 13.91 22 134614 831 90492980
Left ventricular dysfunction 42.00 13.91 77 134559 14592 90479219
Stress cardiomyopathy 41.95 13.91 73 134563 13282 90480529
Blood creatinine decreased 41.79 13.91 50 134586 6465 90487346
Coeliac disease 41.37 13.91 8 134628 44602 90449209
Cardiac output decreased 41.07 13.91 23 134613 997 90492814
Acute myeloid leukaemia 40.87 13.91 93 134543 20547 90473264
Hypertension 40.68 13.91 459 134177 457073 90036738
Respiratory disorder 40.38 13.91 23 134613 64793 90429018
Oesophagitis 40.19 13.91 83 134553 17166 90476645
Malignant pleural effusion 39.90 13.91 34 134602 2930 90490881
Gastric perforation 39.90 13.91 29 134607 1982 90491829
Blood pressure fluctuation 39.86 13.91 14 134622 52399 90441412
Hepatic neoplasm 39.80 13.91 30 134606 2168 90491643
Proteinuria 39.69 13.91 99 134537 23192 90470619
Pancytopenia 39.56 13.91 310 134326 119953 90373858
Hepatotoxicity 38.97 13.91 153 134483 45689 90448122
Breast neoplasm 38.88 13.91 26 134610 1554 90492257
Aspartate aminotransferase increased 38.77 13.91 274 134362 102663 90391148
Subclavian vein thrombosis 38.58 13.91 29 134607 2087 90491724
Eosinophil percentage increased 38.50 13.91 22 134614 992 90492819
Accidental exposure to product 38.45 13.91 8 134628 42358 90451453
Oedema 38.36 13.91 160 134476 200135 90293676
Feeling abnormal 38.33 13.91 124 134512 167111 90326700
Cheilitis 38.15 13.91 42 134594 4965 90488846
Hormone receptor positive breast cancer 38.10 13.91 20 134616 761 90493050
Premature delivery 38.03 13.91 6 134630 38756 90455055
Radiation necrosis 37.95 13.91 19 134617 654 90493157
Brain cancer metastatic 37.34 13.91 13 134623 173 90493638
Dysgeusia 37.31 13.91 166 134470 52394 90441417
Hiccups 37.28 13.91 33 134603 2993 90490818
Pigmentation disorder 37.09 13.91 45 134591 5904 90487907
Upper respiratory tract infection 37.02 13.91 85 134551 128233 90365578
Tongue discolouration 37 13.91 35 134601 3458 90490353
Fluid retention 36.80 13.91 46 134590 88045 90405766
Hand-foot-and-mouth disease 36.67 13.91 17 134619 492 90493319
Early satiety 36.67 13.91 24 134612 1383 90492428
Human epidermal growth factor receptor negative 36.47 13.91 9 134627 30 90493781
Sedation 36.40 13.91 13 134623 48158 90445653
Arterial thrombosis 36.21 13.91 25 134611 1575 90492236
Anastomotic fistula 36.02 13.91 9 134627 32 90493779
Walking aid user 35.98 13.91 5 134631 35501 90458310
Sleep apnoea syndrome 35.91 13.91 3 134633 31744 90462067
Brain neoplasm 35.68 13.91 40 134596 4824 90488987
Drug ineffective for unapproved indication 35.66 13.91 28 134608 66616 90427195
Joint stiffness 35.57 13.91 38 134598 78004 90415807
Lupus-like syndrome 35.54 13.91 14 134622 48832 90444979
Procedural pain 35.50 13.91 4 134632 33356 90460455
Hyperglycaemia 35.45 13.91 160 134476 50810 90443001
Hydronephrosis 35.38 13.91 65 134571 12337 90481474
Brachiocephalic vein thrombosis 35.27 13.91 11 134625 101 90493710
Drug reaction with eosinophilia and systemic symptoms 35.04 13.91 10 134626 42748 90451063
Vocal cord paralysis 35.04 13.91 29 134607 2401 90491410
Pharyngeal inflammation 34.98 13.91 21 134615 1039 90492772
Blood lactate dehydrogenase increased 34.89 13.91 101 134535 25831 90467980
Hip arthroplasty 34.86 13.91 37 134599 76171 90417640
HER2 positive breast cancer 34.81 13.91 16 134620 454 90493357
Dermatitis acneiform 34.72 13.91 45 134591 6309 90487502
Acute motor axonal neuropathy 34.61 13.91 9 134627 39 90493772
Gastrooesophageal reflux disease 34.31 13.91 129 134507 166208 90327603
Toothache 34.28 13.91 91 134545 22139 90471672
Dermatomyositis 34.24 13.91 33 134603 3337 90490474
Hand dermatitis 34.23 13.91 17 134619 575 90493236
Chronic kidney disease 33.95 13.91 16 134620 50175 90443636
Foetal exposure during pregnancy 33.51 13.91 11 134625 42964 90450847
Weight decreased 33.43 13.91 769 133867 379141 90114670
Cachexia 33.43 13.91 46 134590 6832 90486979
Invasive ductal breast carcinoma 33.16 13.91 49 134587 7769 90486042
Dermatoglyphic anomaly 33.08 13.91 6 134630 0 90493811
Macular degeneration 32.79 13.91 8 134628 37962 90455849
Hyperchylomicronaemia 32.62 13.91 9 134627 51 90493760
Coagulation factor decreased 32.51 13.91 12 134624 191 90493620
Brain operation 32.51 13.91 17 134619 642 90493169
Wrong technique in product usage process 32.45 13.91 35 134601 71536 90422275
Hemianopia 32.45 13.91 26 134610 2056 90491755
Asthenopia 32.41 13.91 30 134606 2884 90490927
Sequestrectomy 32.34 13.91 18 134618 771 90493040
Transaminases increased 32.32 13.91 125 134511 37067 90456744
Pulmonary mass 32.13 13.91 105 134531 28667 90465144
Pancreatic fistula 32.00 13.91 7 134629 11 90493800
Hyperhidrosis 31.98 13.91 100 134536 136205 90357606
Neutropenic sepsis 31.88 13.91 78 134558 18052 90475759
Steatohepatitis 31.78 13.91 18 134618 798 90493013
Vascular pain 31.59 13.91 19 134617 943 90492868
Cardiac ventricular thrombosis 31.17 13.91 20 134616 1114 90492697
Biliary sepsis 31.16 13.91 19 134617 967 90492844
Bronchospasm 31.15 13.91 84 134552 20625 90473186
Deep vein thrombosis 31.15 13.91 238 134398 91382 90402429
Bone debridement 31.00 13.91 12 134624 219 90493592
Somnolence 30.86 13.91 183 134453 208901 90284910
Vascular device infection 30.82 13.91 60 134576 11892 90481919
Intracranial pressure increased 30.80 13.91 44 134592 6767 90487044
Injection site bruising 30.58 13.91 20 134616 52287 90441524
Blood alkaline phosphatase increased 30.55 13.91 147 134489 47932 90445879
Odynophagia 30.48 13.91 51 134585 8992 90484819
Device issue 30.31 13.91 4 134632 29533 90464278
Oral pain 30.18 13.91 112 134524 32571 90461240
Botryomycosis 30.17 13.91 8 134628 38 90493773
Portal hypertensive gastropathy 30.11 13.91 19 134617 1028 90492783
Adenocarcinoma 30.06 13.91 30 134606 3166 90490645
Sensory disturbance 30.02 13.91 69 134567 15344 90478467
Adnexa uteri mass 29.98 13.91 16 134620 630 90493181
Cholestasis 29.93 13.91 120 134516 36179 90457632
Infusion site induration 29.84 13.91 22 134614 1537 90492274
Peritonitis 29.71 13.91 80 134556 19625 90474186
Retroperitoneal neoplasm metastatic 29.67 13.91 8 134628 41 90493770
Blood lactate dehydrogenase abnormal 29.37 13.91 14 134622 432 90493379
Pseudomonal sepsis 29.22 13.91 34 134602 4268 90489543
Hepatic cancer metastatic 29.22 13.91 14 134622 437 90493374
Computerised tomogram abnormal 29.20 13.91 27 134609 2592 90491219
Incorrect dose administered 29.18 13.91 45 134591 78885 90414926
Penetrating aortic ulcer 29.17 13.91 7 134629 20 90493791
Ill-defined disorder 28.80 13.91 159 134477 184732 90309079
Angina pectoris 28.80 13.91 125 134511 39035 90454776
Oxygen saturation decreased 28.79 13.91 74 134562 107409 90386402
Electrolyte imbalance 28.65 13.91 89 134547 23656 90470155
Treatment noncompliance 28.61 13.91 21 134615 51706 90442105
Subileus 28.51 13.91 31 134605 3613 90490198
Onychomycosis 28.39 13.91 10 134626 37366 90456445
Metastases to heart 28.35 13.91 11 134625 202 90493609
Blood pressure systolic increased 28.20 13.91 27 134609 58318 90435493
Radiation fibrosis - lung 28.07 13.91 8 134628 52 90493759
Blister 28.00 13.91 243 134393 254755 90239056
Pulpitis dental 27.81 13.91 18 134618 1018 90492793
Tooth erosion 27.67 13.91 14 134622 493 90493318
Cancer pain 27.66 13.91 32 134604 3993 90489818
Sinus congestion 27.46 13.91 4 134632 27420 90466391
Pelvic fluid collection 27.45 13.91 18 134618 1041 90492770
Respiratory tract congestion 27.44 13.91 4 134632 27406 90466405
Peritoneal fluid analysis abnormal 27.37 13.91 7 134629 28 90493783
Hepatic mass 27.34 13.91 24 134612 2153 90491658
Metastases to spleen 27.17 13.91 11 134625 227 90493584
Dyschezia 27.14 13.91 27 134609 2838 90490973
Terminal ileitis 27.04 13.91 19 134617 1231 90492580
Left ventricular failure 27.00 13.91 41 134595 6659 90487152
Granulocyte count decreased 26.80 13.91 25 134611 2427 90491384
Gamma-glutamyltransferase abnormal 26.67 13.91 14 134622 533 90493278
Leukonychia 26.63 13.91 8 134628 64 90493747
Gingivitis 26.60 13.91 49 134587 9320 90484491
Acute promyelocytic leukaemia 26.40 13.91 18 134618 1111 90492700
Tumour excision 26.30 13.91 13 134623 435 90493376
Oral pigmentation 26.27 13.91 7 134629 34 90493777
Sopor 26.11 13.91 3 134633 24641 90469170
Vessel puncture site bruise 26.09 13.91 13 134623 443 90493368
Ulcer haemorrhage 25.99 13.91 4 134632 26317 90467494
Colitis ulcerative 25.67 13.91 31 134605 60235 90433576
Diarrhoea haemorrhagic 25.66 13.91 52 134584 10611 90483200
Dermatitis 25.63 13.91 82 134554 22138 90471673
Neutropenic colitis 25.28 13.91 31 134605 4112 90489699
Biliary obstruction 25.27 13.91 28 134608 3334 90490477
Prinzmetal angina 25.24 13.91 17 134619 1028 90492783
Alanine aminotransferase increased 25.24 13.91 278 134358 118060 90375751
Aortic dissection 25.19 13.91 24 134612 2393 90491418
Vasodilatation 25.17 13.91 26 134610 2858 90490953
Hepatic atrophy 25.14 13.91 11 134625 277 90493534
Transaminases 25.13 13.91 8 134628 79 90493732
Small intestinal obstruction 25.08 13.91 79 134557 21155 90472656
Failure to anastomose 25.04 13.91 6 134630 17 90493794
Retroperitoneal lymphadenopathy 24.93 13.91 15 134621 745 90493066
Lymphadenopathy mediastinal 24.88 13.91 27 134609 3140 90490671
Blood potassium decreased 24.82 13.91 138 134498 47589 90446222
Taste disorder 24.82 13.91 33 134603 61513 90432298
Gamma-glutamyltransferase increased 24.81 13.91 117 134519 37835 90455976
Lactic acidosis 24.80 13.91 23 134613 50440 90443371
Ileus paralytic 24.70 13.91 34 134602 5051 90488760
Diplopia 24.54 13.91 96 134540 28618 90465193
Tumour invasion 24.44 13.91 11 134625 297 90493514
Joint injury 24.37 13.91 9 134627 32655 90461156
Oral disorder 24.36 13.91 50 134586 10295 90483516
Mass 24.25 13.91 64 134572 15513 90478298
Catheter site inflammation 24.15 13.91 16 134620 941 90492870
Glossopharyngeal nerve paralysis 24.11 13.91 7 134629 49 90493762
Schistosomiasis 24.11 13.91 5 134631 5 90493806
Pleural neoplasm 23.81 13.91 12 134624 419 90493392
Incorrect route of product administration 23.81 13.91 24 134612 50602 90443209
Hepatic cytolysis 23.75 13.91 100 134536 30816 90462995
COVID-19 23.75 13.91 150 134486 168693 90325118
Calcium ionised increased 23.70 13.91 10 134626 230 90493581
Small intestinal perforation 23.69 13.91 21 134615 1908 90491903
Sudden death 23.68 13.91 51 134585 10858 90482953
Gait disturbance 23.64 13.91 260 134376 260236 90233575
Hyperchlorhydria 23.58 13.91 21 134615 1920 90491891
Bone marrow infiltration 23.52 13.91 15 134621 827 90492984
Ingrowing nail 23.51 13.91 25 134611 2842 90490969
Psychological trauma 23.47 13.91 18 134618 1335 90492476
Metastases to thyroid 23.46 13.91 6 134630 24 90493787
Ovarian stromal hyperplasia 23.46 13.91 6 134630 24 90493787
Protein-losing gastroenteropathy 23.46 13.91 11 134625 327 90493484
Abnormal behaviour 23.37 13.91 3 134633 22625 90471186
Metastases to stomach 23.26 13.91 10 134626 241 90493570
Venoocclusive liver disease 23.20 13.91 36 134600 5957 90487854
Purulent discharge 23.10 13.91 34 134602 5371 90488440
Paraparesis 23 13.91 25 134611 2913 90490898
Bronchiectasis 22.97 13.91 3 134633 22327 90471484
Muscle swelling 22.73 13.91 13 134623 587 90493224
Chronic sinusitis 22.65 13.91 4 134632 23798 90470013
Gastrointestinal disorder 22.58 13.91 258 134378 256429 90237382
Post-traumatic neck syndrome 22.55 13.91 23 134613 2491 90491320
Mucosal necrosis 22.55 13.91 8 134628 113 90493698
Disturbance in attention 22.53 13.91 22 134614 47087 90446724
Ejection fraction 22.50 13.91 25 134611 2986 90490825
Neck pain 22.46 13.91 90 134546 113873 90379938
Increased liver stiffness 22.43 13.91 5 134631 9 90493802
Mucosal disorder 22.43 13.91 24 134612 2747 90491064
Injection site swelling 22.23 13.91 34 134602 59805 90434006
Cholangitis 22.22 13.91 39 134597 7143 90486668
Rhabdomyolysis 22.22 13.91 26 134610 51230 90442581
Ischaemia 22.19 13.91 33 134603 5262 90488549
Nightmare 22.15 13.91 3 134633 21722 90472089
Metastases to thorax 22.15 13.91 10 134626 272 90493539
Osteomyelitis 22.12 13.91 91 134545 27755 90466056
Chemotherapy cardiotoxicity attenuation 22.05 13.91 4 134632 0 90493811
Dental care 22.05 13.91 17 134619 1271 90492540
Cardiac tamponade 22.04 13.91 34 134602 5598 90488213
Cardiac failure congestive 22.04 13.91 74 134562 98620 90395191
Multiple sclerosis 21.93 13.91 7 134629 27833 90465978
Metastases to spinal cord 21.85 13.91 10 134626 281 90493530
Large intestine perforation 21.77 13.91 46 134590 9666 90484145
Neuroendocrine breast tumour 21.75 13.91 6 134630 34 90493777
Enterocolitis haemorrhagic 21.56 13.91 19 134617 1713 90492098
Gastrointestinal inflammation 21.55 13.91 37 134599 6659 90487152
Pulmonary thrombosis 21.54 13.91 46 134590 9736 90484075
Anal erythema 21.52 13.91 10 134626 291 90493520
Intentional product use issue 21.51 13.91 212 134424 216680 90277131
Drug resistance 21.48 13.91 96 134540 30353 90463458
Herpangina 21.46 13.91 6 134630 36 90493775
Metastases to soft tissue 21.46 13.91 10 134626 293 90493518
Hypotension 21.43 13.91 347 134289 325050 90168761
Pneumatosis intestinalis 21.43 13.91 26 134610 3411 90490400
Peripheral motor neuropathy 21.34 13.91 20 134616 1953 90491858
Nervousness 21.33 13.91 12 134624 34044 90459767
Limbal stem cell deficiency 21.32 13.91 6 134630 37 90493774
Keratitis 21.31 13.91 28 134608 3978 90489833
Angioedema 21.21 13.91 40 134596 64836 90428975
Lymphangiopathy 21.18 13.91 5 134631 13 90493798
Hyperammonaemia 21.13 13.91 36 134600 6439 90487372
Herpes simplex encephalitis 21.12 13.91 11 134625 412 90493399
Back disorder 20.99 13.91 6 134630 25625 90468186
Faeces soft 20.97 13.91 39 134597 7472 90486339
ECG signs of myocardial ischaemia 20.92 13.91 7 134629 82 90493729
Motion sickness 20.90 13.91 16 134620 1184 90492627
Nervous system disorder 20.78 13.91 75 134561 21518 90472293
Oncologic complication 20.67 13.91 9 134627 224 90493587
Eyelid ptosis 20.59 13.91 43 134593 8963 90484848
Metastases to pelvis 20.55 13.91 12 134624 564 90493247
Femoral artery embolism 20.54 13.91 6 134630 43 90493768
Cytomegalovirus infection 20.41 13.91 7 134629 26595 90467216
Vertebral column mass 20.38 13.91 9 134627 232 90493579
Sinus disorder 20.37 13.91 13 134623 34434 90459377
Polyneuropathy in malignant disease 20.33 13.91 7 134629 90 90493721
Dermatitis atopic 20.16 13.91 5 134631 23467 90470344
Blood magnesium decreased 20.04 13.91 60 134576 15633 90478178
Illness 20.03 13.91 59 134577 81910 90411901
Skin mass 20.02 13.91 38 134598 7392 90486419
Portal vein thrombosis 19.99 13.91 24 134612 3114 90490697
Metastases to kidney 19.96 13.91 9 134627 244 90493567
Haemolysis 19.88 13.91 41 134595 8469 90485342
Hypervolaemia 19.87 13.91 12 134624 32745 90461066
Body temperature decreased 19.85 13.91 79 134557 23737 90470074
Arteriosclerosis coronary artery 19.83 13.91 44 134592 9559 90484252
Folate deficiency 19.83 13.91 24 134612 3141 90490670
Metastases to muscle 19.81 13.91 8 134628 164 90493647
Gram stain positive 19.78 13.91 7 134629 98 90493713
Cerebral infarction 19.64 13.91 85 134551 26511 90467300
Malignant peritoneal neoplasm 19.62 13.91 13 134623 765 90493046
Eye pain 19.58 13.91 22 134614 44146 90449665
Blood glucose increased 19.55 13.91 74 134562 95172 90398639
Loss of consciousness 19.51 13.91 125 134511 140113 90353698
Bile duct stenosis 19.50 13.91 18 134618 1724 90492087
Hypercalcaemia of malignancy 19.46 13.91 9 134627 259 90493552
Neurological decompensation 19.45 13.91 25 134611 3476 90490335
Pneumoperitoneum 19.40 13.91 18 134618 1735 90492076
Chemical peritonitis 19.40 13.91 7 134629 104 90493707
Oral mucosal blistering 19.39 13.91 36 134600 6888 90486923
Paresis 19.36 13.91 22 134614 2692 90491119
Vulval disorder 19.30 13.91 16 134620 1328 90492483
Peritoneal disorder 19.29 13.91 12 134624 633 90493178
Uterine enlargement 19.25 13.91 16 134620 1332 90492479
Tumour marker abnormal 19.21 13.91 10 134626 374 90493437
Evans syndrome 19.21 13.91 10 134626 374 90493437
Electric shock sensation 19.10 13.91 17 134619 1553 90492258
Carcinoid tumour pulmonary 18.99 13.91 11 134625 509 90493302
Tumour necrosis 18.88 13.91 14 134622 987 90492824
Brain natriuretic peptide decreased 18.87 13.91 6 134630 59 90493752
Muscular weakness 18.86 13.91 206 134430 206460 90287351
Hypertransaminasaemia 18.80 13.91 59 134577 15766 90478045
Protein total decreased 18.78 13.91 36 134600 7053 90486758
Myocardial ischaemia 18.77 13.91 54 134582 13760 90480051
Necrotising oesophagitis 18.55 13.91 11 134625 532 90493279
Posterior reversible encephalopathy syndrome 18.54 13.91 74 134562 22265 90471546
Rhinorrhoea 18.53 13.91 68 134568 88248 90405563
Wound dehiscence 18.52 13.91 32 134604 5790 90488021
Carbohydrate antigen 19-9 increased 18.49 13.91 9 134627 291 90493520
Neuromuscular toxicity 18.47 13.91 9 134627 292 90493519
Hepatic cancer 18.45 13.91 29 134607 4852 90488959
Ocular icterus 18.42 13.91 26 134610 3954 90489857
Nail toxicity 18.41 13.91 10 134626 408 90493403
Vein disorder 18.36 13.91 31 134605 5505 90488306
Bone fistula 18.27 13.91 6 134630 66 90493745
Papillary thyroid cancer 18.24 13.91 21 134615 2606 90491205
Nail disorder 18.19 13.91 150 134486 58917 90434894
Hypertensive crisis 18.17 13.91 63 134573 17721 90476090
Agitation 18.12 13.91 46 134590 67052 90426759
Excessive granulation tissue 18.06 13.91 13 134623 875 90492936
Pulmonary hypertension 17.97 13.91 22 134614 42501 90451310
Caesarean section 17.94 13.91 3 134633 18574 90475237
Artificial menopause 17.88 13.91 5 134631 30 90493781
Obstructive airways disorder 17.88 13.91 8 134628 25861 90467950
Gingival swelling 17.87 13.91 29 134607 4984 90488827
Pancreatic atrophy 17.71 13.91 9 134627 320 90493491
Neutrophil count abnormal 17.69 13.91 26 134610 4102 90489709
Ear pain 17.64 13.91 37 134599 57665 90436146
Polyarthritis 17.64 13.91 3 134633 18347 90475464
Aortic thrombosis 17.56 13.91 15 134621 1297 90492514
Pituitary tumour 17.54 13.91 13 134623 916 90492895
Capillary nail refill test abnormal 17.50 13.91 6 134630 76 90493735
Colitis ischaemic 17.50 13.91 49 134587 12297 90481514
Interstitial lung disease 17.46 13.91 182 134454 76223 90417588
Acute respiratory failure 17.31 13.91 23 134613 42895 90450916
Metastases to bladder 17.24 13.91 8 134628 232 90493579
Rectal cancer recurrent 17.22 13.91 5 134631 35 90493776
Metastases to bone marrow 17.22 13.91 11 134625 608 90493203
Multiple organ dysfunction syndrome 17.16 13.91 166 134470 68170 90425641
Female sexual dysfunction 17.16 13.91 6 134630 81 90493730
Osteoradionecrosis 17.09 13.91 7 134629 149 90493662
Oral toxicity 17.06 13.91 4 134632 10 90493801
Radioisotope scan 17.06 13.91 4 134632 10 90493801
Hyperglycaemic hyperosmolar nonketotic syndrome 17.01 13.91 15 134621 1354 90492457
Frequent bowel movements 17.00 13.91 37 134599 56898 90436913
Hyperbaric oxygen therapy 16.98 13.91 5 134631 37 90493774
Gastroenteropancreatic neuroendocrine tumour disease 16.98 13.91 5 134631 37 90493774
Tenderness 16.96 13.91 82 134554 26786 90467025
Premature baby 16.95 13.91 8 134628 25069 90468742
Musculoskeletal chest pain 16.85 13.91 75 134561 23675 90470136
Hyperproteinaemia 16.83 13.91 7 134629 155 90493656
Protein urine 16.78 13.91 12 134624 800 90493011
Candida infection 16.74 13.91 97 134539 33960 90459851
Hepatic steatosis 16.73 13.91 103 134533 36842 90456969
Soft tissue infection 16.59 13.91 21 134615 2876 90490935
Eosinophilia 16.55 13.91 11 134625 28522 90465289
Amaurosis 16.54 13.91 12 134624 818 90492993
Paraneoplastic syndrome 16.51 13.91 11 134625 653 90493158
Therapy non-responder 16.49 13.91 127 134509 136577 90357234
Blood phosphorus decreased 16.45 13.91 28 134608 5006 90488805
Gastric varices haemorrhage 16.43 13.91 7 134629 165 90493646
Skin disorder 16.41 13.91 102 134534 36604 90457207
Pathological fracture 16.39 13.91 41 134595 9619 90484192
Gastrointestinal anastomotic leak 16.37 13.91 8 134628 261 90493550
Bone cancer 16.37 13.91 16 134620 1646 90492165
Sputum discoloured 16.29 13.91 5 134631 20386 90473425
Colorectal cancer recurrent 16.29 13.91 4 134632 13 90493798
Ankle fracture 16.26 13.91 5 134631 20365 90473446
Rectal perforation 16.24 13.91 10 134626 518 90493293
IVth nerve paralysis 16.22 13.91 5 134631 44 90493767
Fistula 16.18 13.91 47 134589 12042 90481769
Radiation injury 16.12 13.91 11 134625 680 90493131
Chronic cutaneous lupus erythematosus 16.08 13.91 12 134624 854 90492957
Obstruction gastric 16.08 13.91 14 134622 1242 90492569
Weight fluctuation 16.05 13.91 65 134571 19684 90474127
Oestrogen receptor assay positive 16.00 13.91 10 134626 532 90493279
Periodontal disease 15.97 13.91 16 134620 1696 90492115
Pain in jaw 15.94 13.91 124 134512 47861 90445950
Cytokine release syndrome 15.94 13.91 11 134625 27962 90465849
Burn oesophageal 15.91 13.91 9 134627 398 90493413
Blood pressure increased 15.90 13.91 202 134434 197015 90296796
Liver scan abnormal 15.83 13.91 5 134631 48 90493763
Pleural disorder 15.76 13.91 11 134625 705 90493106
Drug level increased 15.71 13.91 11 134625 27751 90466060
Product prescribing error 15.71 13.91 13 134623 30132 90463679
Dyspepsia 15.59 13.91 204 134432 197956 90295855
Diverticulitis 15.54 13.91 27 134609 45160 90448651
Restless legs syndrome 15.45 13.91 7 134629 22463 90471348
Hormone receptor positive HER2 negative breast cancer 15.45 13.91 8 134628 296 90493515
Respiratory arrest 15.43 13.91 16 134620 33295 90460516
Blood phosphorus increased 15.42 13.91 25 134611 4293 90489518
Osteosclerosis 15.41 13.91 25 134611 4295 90489516
Cardiac murmur 15.39 13.91 4 134632 18190 90475621
Coagulopathy 15.37 13.91 72 134564 23217 90470594
Jaundice cholestatic 15.37 13.91 41 134595 10002 90483809
Pericardial effusion malignant 15.35 13.91 7 134629 195 90493616
Pelvic pain 15.34 13.91 54 134582 15303 90478508
Device malfunction 15.28 13.91 6 134630 20971 90472840
Wound treatment 15.25 13.91 7 134629 198 90493613
Actinomycosis 15.23 13.91 13 134623 1123 90492688
Lung neoplasm 15.21 13.91 32 134604 6703 90487108
Facial asymmetry 15.21 13.91 12 134624 928 90492883
Venous thrombosis limb 15.12 13.91 22 134614 3440 90490371
Onychalgia 15.05 13.91 13 134623 1141 90492670
Injection site haemorrhage 15.02 13.91 12 134624 28306 90465505
Circulatory collapse 15.00 13.91 75 134561 24829 90468982
Tumour haemorrhage 14.98 13.91 17 134619 2077 90491734
Ischaemic stroke 14.98 13.91 69 134567 22097 90471714
Impaired work ability 14.97 13.91 5 134631 19321 90474490
Normal newborn 14.97 13.91 8 134628 23354 90470457
Extrapyramidal disorder 14.96 13.91 3 134633 16300 90477511
Liver abscess 14.95 13.91 22 134614 3474 90490337
Hypocalcaemia 14.92 13.91 111 134525 42257 90451554
Tooth avulsion 14.91 13.91 5 134631 59 90493752
Radiation pneumonitis 14.88 13.91 16 134620 1842 90491969
Myopathy toxic 14.86 13.91 10 134626 604 90493207
Thrombocytopenic purpura 14.86 13.91 16 134620 1845 90491966
Ureteric obstruction 14.83 13.91 17 134619 2101 90491710
Pulmonary hilum mass 14.77 13.91 6 134630 125 90493686
Lip pain 14.75 13.91 17 134619 2113 90491698
Abdominal symptom 14.74 13.91 9 134627 459 90493352
Pneumothorax 14.72 13.91 62 134574 19105 90474706
Malaise 14.70 13.91 716 133920 585270 89908541
Trismus 14.69 13.91 26 134610 4795 90489016
Vasospasm 14.67 13.91 12 134624 977 90492834
Lymphangitis 14.67 13.91 12 134624 977 90492834
Cystitis haemorrhagic 14.61 13.91 28 134608 5485 90488326
Renal hydrocele 14.60 13.91 4 134632 22 90493789
Nephrolithiasis 14.57 13.91 32 134604 49053 90444758
Venous thrombosis 14.53 13.91 28 134608 5509 90488302
Mastitis 14.52 13.91 20 134616 2973 90490838
Hepatic pain 14.49 13.91 22 134614 3573 90490238
Hepatitis 14.49 13.91 55 134581 70684 90423127
Hypermutation 14.47 13.91 5 134631 65 90493746
Influenza like illness 14.44 13.91 66 134570 80545 90413266
Uveitis 14.44 13.91 3 134633 15900 90477911
Skin sensitisation 14.40 13.91 12 134624 1003 90492808
Mediastinal disorder 14.24 13.91 9 134627 488 90493323
Skin reaction 14.24 13.91 60 134576 18493 90475318
Peripheral artery thrombosis 14.24 13.91 17 134619 2193 90491618
Lip ulceration 14.23 13.91 17 134619 2195 90491616
Cell death 14.20 13.91 20 134616 3035 90490776
Respiratory tract infection 14.09 13.91 43 134593 59035 90434776
Bone cancer metastatic 14.09 13.91 7 134629 237 90493574
Physical deconditioning 14.09 13.91 17 134619 2218 90491593
Adverse reaction 14.07 13.91 14 134622 29698 90464113
Rectal neoplasm 14.03 13.91 4 134632 26 90493785
Progesterone receptor assay positive 14.01 13.91 8 134628 360 90493451
Hepatocellular injury 13.92 13.91 82 134554 28876 90464935

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Palmar-plantar erythrodysaesthesia syndrome 2884.99 13.93 1113 64729 19469 42536024
Diarrhoea 1601.03 13.93 2670 63172 458179 42097314
Disease progression 1281.03 13.93 1329 64513 142327 42413166
Arteriospasm coronary 647.58 13.93 252 65590 4486 42551007
Neuropathy peripheral 576.55 13.93 747 65095 101106 42454387
Death 525.56 13.93 1755 64087 469430 42086063
Mucosal inflammation 440.37 13.93 458 65384 48916 42506577
Myelosuppression 402.14 13.93 398 65444 40063 42515430
Nausea 350.82 13.93 1372 64470 395427 42160066
Vomiting 308.74 13.93 1065 64777 288658 42266835
Stomatitis 301.39 13.93 380 65462 49949 42505544
Metastases to liver 295.12 13.93 226 65616 16100 42539393
Enteritis 281.57 13.93 187 65655 10629 42544864
Malignant neoplasm progression 273.82 13.93 551 65291 107849 42447644
Dehydration 267.76 13.93 641 65201 141126 42414367
Anastomotic leak 240.79 13.93 76 65766 698 42554795
Decreased appetite 233.86 13.93 742 65100 192395 42363098
Neurotoxicity 226.29 13.93 228 65614 23423 42532070
Dihydropyrimidine dehydrogenase deficiency 215.36 13.93 47 65795 68 42555425
Gastrointestinal toxicity 210.65 13.93 109 65733 3870 42551623
Enterocolitis 207.52 13.93 150 65692 9779 42545714
Skin toxicity 194.46 13.93 123 65719 6426 42549067
Gastrointestinal perforation 190.13 13.93 106 65736 4380 42551113
Intestinal obstruction 178.51 13.93 215 65627 26943 42528550
Metastases to lung 178.16 13.93 145 65697 11279 42544214
Cardiotoxicity 170.65 13.93 119 65723 7326 42548167
Tumour perforation 157.47 13.93 50 65792 469 42555024
Metastases to peritoneum 155.83 13.93 76 65766 2373 42553120
Neutropenia 148.81 13.93 656 65186 198775 42356718
Drug abuse 143.24 13.93 4 65838 104767 42450726
Drug ineffective 136.77 13.93 508 65334 629689 41925804
Headache 135.67 13.93 103 65739 239266 42316227
Completed suicide 134.47 13.93 3 65839 96462 42459031
Stomal varices 133.37 13.93 33 65809 106 42555387
Anastomotic complication 130.60 13.93 42 65800 412 42555081
Bone marrow failure 128.23 13.93 203 65639 32890 42522603
Condition aggravated 125.23 13.93 131 65711 260623 42294870
Arthralgia 121.90 13.93 84 65758 205154 42350339
Thrombocytopenia 118.50 13.93 594 65248 189685 42365808
Therapy cessation 109.18 13.93 146 65696 20304 42535189
Ileus 108.92 13.93 141 65701 18998 42536495
Colon cancer metastatic 108.54 13.93 53 65789 1659 42553834
Abdominal pain 103.73 13.93 573 65269 189898 42365595
Neoplasm progression 102.97 13.93 171 65671 28829 42526664
Therapy partial responder 97.91 13.93 137 65705 19884 42535609
Gastrointestinal injury 96.57 13.93 43 65799 1086 42554407
Product dose omission issue 95.92 13.93 60 65782 154305 42401188
Acute promyelocytic leukaemia 93.00 13.93 37 65805 699 42554794
Carcinoembryonic antigen increased 92.51 13.93 39 65803 859 42554634
Fingerprint loss 92.29 13.93 21 65821 41 42555452
Gastrointestinal anastomotic leak 89.47 13.93 34 65808 565 42554928
Terminal ileitis 88.87 13.93 34 65808 576 42554917
Overdose 87.27 13.93 27 65815 105237 42450256
Pneumonia 86.92 13.93 347 65495 421802 42133691
Reactive capillary endothelial proliferation 82.49 13.93 18 65824 26 42555467
Dysphagia 81.06 13.93 272 65570 72447 42483046
Hyperammonaemic encephalopathy 79.88 13.93 51 65791 2707 42552786
Intestinal perforation 79.59 13.93 91 65751 10783 42544710
Fall 78.61 13.93 152 65690 234368 42321125
Portal hypertension 77.25 13.93 62 65780 4725 42550768
Drug interaction 77.14 13.93 188 65654 266811 42288682
Anxiety 76.55 13.93 44 65798 118516 42436977
Hiccups 76.12 13.93 94 65748 12077 42543416
Depression 75.29 13.93 39 65803 111324 42444169
Metastases to lymph nodes 74.84 13.93 67 65775 5931 42549562
Colitis 72.50 13.93 196 65646 46376 42509117
Haematotoxicity 67.35 13.93 84 65758 10901 42544592
Wound dehiscence 67.32 13.93 52 65790 3748 42551745
Proteinuria 66.64 13.93 124 65718 22859 42532634
Laryngospasm 65.76 13.93 40 65802 1948 42553545
Pruritus 64.40 13.93 121 65721 188650 42366843
Cardiac failure congestive 64.04 13.93 26 65816 85576 42469917
Rectal perforation 63.71 13.93 26 65816 526 42554967
Paraesthesia 63.47 13.93 253 65589 73206 42482287
Focal nodular hyperplasia 62.40 13.93 19 65823 153 42555340
Ascites 60.51 13.93 209 65633 56469 42499024
Metastases to central nervous system 60.03 13.93 77 65765 10278 42545215
Toxic leukoencephalopathy 59.98 13.93 27 65815 700 42554793
Hypoaesthesia 58.46 13.93 242 65600 71221 42484272
COVID-19 58.12 13.93 56 65786 115892 42439601
Plasma cell myeloma 57.89 13.93 4 65838 47574 42507919
Recall phenomenon 57.67 13.93 25 65817 591 42554902
Metastasis 57.61 13.93 52 65790 4653 42550840
Asthma 57.29 13.93 13 65829 62301 42493192
Peritonitis 57.14 13.93 103 65739 18530 42536963
Intentional product misuse 56.74 13.93 13 65829 61887 42493606
Proteus infection 56.60 13.93 32 65810 1358 42554135
Oesophageal haemorrhage 56.09 13.93 32 65810 1382 42554111
Venoocclusive liver disease 55.67 13.93 74 65768 10228 42545265
Weight increased 54.30 13.93 52 65790 107931 42447562
Gastric perforation 54.08 13.93 42 65800 3051 42552442
Hepatic lesion 53.71 13.93 49 65793 4445 42551048
Dizziness 53.65 13.93 201 65641 249053 42306440
Necrotising fasciitis 53.23 13.93 49 65793 4497 42550996
Musculoskeletal stiffness 53.21 13.93 12 65830 57753 42497740
Hypokalaemia 52.61 13.93 235 65607 71486 42484007
Cough 52.48 13.93 124 65718 177979 42377514
Inappropriate schedule of product administration 52.04 13.93 43 65799 95859 42459634
Small intestinal obstruction 51.92 13.93 94 65748 16967 42538526
Injection site pain 51.28 13.93 13 65829 57785 42497708
Hallucination 50.90 13.93 13 65829 57494 42497999
Azotaemia 50.87 13.93 54 65788 5890 42549603
Cytokine release syndrome 50.71 13.93 5 65837 44522 42510971
Obstruction gastric 50.12 13.93 27 65815 1041 42554452
Subileus 49.30 13.93 42 65800 3479 42552014
Biliary obstruction 48.27 13.93 40 65802 3189 42552304
Splenorenal shunt 47.83 13.93 10 65832 10 42555483
Tumour marker increased 47.21 13.93 24 65818 820 42554673
Cheilitis 46.88 13.93 36 65806 2572 42552921
Therapy interrupted 46.67 13.93 105 65737 22145 42533348
Non-cirrhotic portal hypertension 46.48 13.93 19 65823 386 42555107
Rhabdomyolysis 46.15 13.93 32 65810 77987 42477506
Vascular pain 46.04 13.93 16 65826 203 42555290
Skin exfoliation 45.90 13.93 155 65687 41398 42514095
Agitation 45.76 13.93 21 65821 64293 42491200
Aggression 45.31 13.93 7 65835 44156 42511337
Psoriasis 44.96 13.93 10 65832 48594 42506899
Leukopenia 44.75 13.93 231 65611 74515 42480978
Confusional state 44.50 13.93 123 65719 167474 42388019
Pancreatic neuroendocrine tumour metastatic 44.41 13.93 14 65828 128 42555365
Performance status decreased 44.20 13.93 45 65797 4675 42550818
Prinzmetal angina 44.10 13.93 27 65815 1330 42554163
Electrocardiogram ST segment elevation 43.97 13.93 50 65792 5889 42549604
Induration 43.71 13.93 25 65817 1085 42554408
Stoma site haemorrhage 43.52 13.93 25 65817 1094 42554399
Hand-foot-genital syndrome 43.46 13.93 10 65832 21 42555472
Rectal tenesmus 42.93 13.93 25 65817 1123 42554370
Hyperbilirubinaemia 42.85 13.93 97 65745 20538 42534955
Dermatitis acneiform 42.44 13.93 56 65786 7683 42547810
Suicidal ideation 42.40 13.93 11 65831 48150 42507343
Pneumatosis intestinalis 42.14 13.93 44 65798 4708 42550785
Hypovolaemic shock 41.95 13.93 59 65783 8600 42546893
Prostate cancer 41.67 13.93 9 65833 44634 42510859
Polyneuropathy 41.32 13.93 90 65752 18571 42536922
Fatigue 40.78 13.93 919 64923 434722 42120771
Nasopharyngitis 40.44 13.93 42 65800 83954 42471539
Influenza 40.21 13.93 23 65819 62152 42493341
Joint swelling 40.10 13.93 28 65814 67994 42487499
Portal shunt 39.98 13.93 10 65832 34 42555459
Chronic obstructive pulmonary disease 39.90 13.93 24 65818 63090 42492403
Rectal cancer metastatic 39.26 13.93 15 65827 253 42555240
Metastatic gastric cancer 39.09 13.93 13 65829 143 42555350
Hypoalbuminaemia 38.88 13.93 79 65763 15531 42539962
Peripheral ischaemia 38.81 13.93 49 65793 6436 42549057
Diaphragmatic spasm 38.63 13.93 12 65830 104 42555389
Cytomegalovirus infection 38.49 13.93 3 65839 32303 42523190
Faecal volume decreased 38.27 13.93 14 65828 208 42555285
Colon cancer recurrent 38.13 13.93 12 65830 109 42555384
Large intestinal obstruction 37.96 13.93 27 65815 1715 42553778
Pancreatitis viral 37.78 13.93 8 65834 9 42555484
Sinusitis 37.64 13.93 13 65829 47279 42508214
Large intestine perforation 37.61 13.93 59 65783 9477 42546016
Insomnia 37.54 13.93 79 65763 118174 42437319
Asthenia 37.32 13.93 625 65217 280168 42275325
Electrolyte imbalance 37.32 13.93 82 65760 17019 42538474
Prothrombin level decreased 37.03 13.93 23 65819 1163 42554330
Somnolence 36.38 13.93 105 65737 141000 42414493
Colorectal cancer metastatic 36.13 13.93 21 65821 940 42554553
Dyspnoea 36.06 13.93 475 65367 442146 42113347
Foetal exposure during pregnancy 35.98 13.93 14 65828 47297 42508196
Dysaesthesia pharynx 35.81 13.93 10 65832 57 42555436
Wheezing 35.81 13.93 20 65822 54761 42500732
Bradycardia 35.53 13.93 48 65794 85436 42470057
Leukoencephalopathy 35.48 13.93 41 65801 4913 42550580
Hospice care 35.44 13.93 54 65788 8459 42547034
Myalgia 35.06 13.93 59 65783 96021 42459472
Hypertriglyceridaemia 34.98 13.93 59 65783 10067 42545426
Anal erythema 34.95 13.93 11 65831 100 42555393
Mucosal disorder 34.74 13.93 28 65814 2146 42553347
Clostridial infection 34.59 13.93 36 65806 3838 42551655
Nasal congestion 34.43 13.93 3 65839 29498 42525995
Temperature intolerance 33.24 13.93 39 65803 4749 42550744
Oesophagitis 33.15 13.93 73 65769 15174 42540319
Anal prolapse 32.85 13.93 6 65836 0 42555493
Intestinal ischaemia 32.83 13.93 55 65787 9333 42546160
Drug reaction with eosinophilia and systemic symptoms 32.75 13.93 12 65830 42063 42513430
Protein urine 32.69 13.93 20 65822 984 42554509
Urticaria 32.39 13.93 40 65802 73996 42481497
Nose deformity 32.32 13.93 13 65829 253 42555240
Eosinophilia 32.02 13.93 6 65836 32893 42522600
Nephrotic syndrome 31.73 13.93 52 65790 8666 42546827
Drug dependence 31.28 13.93 4 65838 29090 42526403
Upper respiratory tract infection 31.22 13.93 13 65829 42160 42513333
Failure to anastomose 31.06 13.93 12 65830 209 42555284
Therapeutic product effect decreased 30.75 13.93 11 65831 39139 42516354
Seizure 30.14 13.93 91 65751 120470 42435023
Tumour fistulisation 29.82 13.93 10 65832 113 42555380
Pelvic abscess 29.46 13.93 19 65823 1026 42554467
Gastrointestinal stoma necrosis 29.44 13.93 7 65835 18 42555475
Hepatectomy 29.28 13.93 10 65832 120 42555373
Feeling abnormal 29.19 13.93 39 65803 69747 42485746
Dysaesthesia 28.85 13.93 27 65815 2530 42552963
Ear malformation 28.81 13.93 13 65829 339 42555154
Sedation 28.73 13.93 6 65836 30469 42525024
Wrong technique in product usage process 28.69 13.93 15 65827 42620 42512873
Bronchitis 28.39 13.93 19 65823 47182 42508311
Balanoposthitis 28.32 13.93 22 65820 1599 42553894
Blood pressure fluctuation 28.21 13.93 4 65838 26904 42528589
Proctalgia 28.13 13.93 44 65798 7049 42548444
Electrocardiogram QT prolonged 27.90 13.93 20 65822 47925 42507568
Pulmonary embolism 27.88 13.93 295 65547 119317 42436176
Erectile dysfunction 27.84 13.93 3 65839 24910 42530583
Irritability 27.65 13.93 5 65837 28123 42527370
Peripheral sensory neuropathy 27.58 13.93 49 65793 8713 42546780
Abnormal behaviour 27.58 13.93 4 65838 26447 42529046
Device occlusion 27.57 13.93 48 65794 8402 42547091
Arthropathy 27.55 13.93 6 65836 29591 42525902
Neutrophil count decreased 27.52 13.93 180 65662 63235 42492258
Lactic acidosis 27.52 13.93 18 65824 45243 42510250
Treatment noncompliance 27.27 13.93 12 65830 37660 42517833
Drug hypersensitivity 27.06 13.93 72 65770 99317 42456176
Central pain syndrome 27.01 13.93 10 65832 154 42555339
Incorrect route of product administration 26.98 13.93 3 65839 24302 42531191
Gastroenteritis radiation 26.91 13.93 12 65830 304 42555189
Intestinal dilatation 26.86 13.93 21 65821 1540 42553953
Aortic thrombosis 26.64 13.93 18 65824 1052 42554441
Portal vein thrombosis 26.64 13.93 34 65808 4515 42550978
Arterial thrombosis 26.55 13.93 22 65820 1754 42553739
Gastrointestinal disorder 26.41 13.93 142 65700 46511 42508982
Therapy change 26.21 13.93 32 65810 4063 42551430
Pharyngeal inflammation 26.10 13.93 15 65827 657 42554836
Tumour necrosis 25.90 13.93 21 65821 1623 42553870
Pigmentation disorder 25.88 13.93 28 65814 3120 42552373
Heart rate decreased 25.87 13.93 12 65830 36520 42518973
Skin discolouration 25.83 13.93 81 65761 20809 42534684
Coronary artery disease 25.69 13.93 27 65815 53693 42501800
Muscular weakness 25.48 13.93 57 65785 83441 42472052
Acute kidney injury 25.39 13.93 407 65435 366930 42188563
Skin fissures 25.33 13.93 50 65792 9626 42545867
Gastrointestinal mucosal necrosis 25.23 13.93 10 65832 187 42555306
Back pain 25.12 13.93 123 65719 141653 42413840
Psychotic disorder 25.09 13.93 7 65835 29201 42526292
Hepatic atrophy 24.84 13.93 10 65832 195 42555298
Basal cell carcinoma 24.75 13.93 3 65839 22730 42532763
Acute coronary syndrome 24.58 13.93 64 65778 14801 42540692
Memory impairment 24.29 13.93 25 65817 50197 42505296
Wound infection 24.15 13.93 45 65797 8301 42547192
Malignant ascites 24.14 13.93 14 65828 624 42554869
Mucosal toxicity 23.96 13.93 11 65831 299 42555194
Cardiac haemangioma benign 23.91 13.93 5 65837 5 42555488
Arthritis 23.89 13.93 18 65824 42047 42513446
Loss of personal independence in daily activities 23.87 13.93 25 65817 49791 42505702
Idiosyncratic drug reaction 23.86 13.93 13 65829 513 42554980
Contusion 23.80 13.93 18 65824 41967 42513526
Paronychia 23.66 13.93 31 65811 4224 42551269
Disseminated intravascular coagulation 23.52 13.93 88 65754 24706 42530787
Interstitial lung disease 23.46 13.93 204 65638 78258 42477235
Gastric dilatation 23.46 13.93 15 65827 798 42554695
Hyperfibrinolysis 23.43 13.93 6 65836 23 42555470
Hypermutation 23.36 13.93 7 65835 53 42555440
Cellulitis 23.22 13.93 37 65805 61548 42493945
Sleep disorder 23.20 13.93 24 65818 48071 42507422
Thrombotic thrombocytopenic purpura 23.17 13.93 29 65813 3775 42551718
Sleep apnoea syndrome 23.16 13.93 3 65839 21605 42533888
Palmar erythema 23.12 13.93 13 65829 546 42554947
Blood bilirubin increased 22.84 13.93 127 65715 42125 42513368
Gastrointestinal stoma complication 22.72 13.93 19 65823 1534 42553959
Neutropenic sepsis 22.71 13.93 65 65777 15881 42539612
Neck pain 22.62 13.93 9 65833 30005 42525488
Metastases to eye 22.57 13.93 8 65834 108 42555385
Disturbance in attention 22.44 13.93 9 65833 29857 42525636
Chronic kidney disease 22.31 13.93 24 65818 47217 42508276
Mouth ulceration 22.30 13.93 62 65780 14901 42540592
Ventricular fibrillation 22.29 13.93 99 65743 30024 42525469
Hepatic failure 22.27 13.93 117 65725 37983 42517510
Alopecia 22.26 13.93 97 65745 29179 42526314
Accidental overdose 22.18 13.93 8 65834 28322 42527171
Blood albumin decreased 22.15 13.93 63 65779 15339 42540154
Migraine 22.00 13.93 6 65836 25408 42530085
Colostomy 21.94 13.93 13 65829 603 42554890
Blood glucose increased 21.93 13.93 51 65791 73648 42481845
Dermatoglyphic anomaly 21.90 13.93 4 65838 0 42555493
Hypertelorism 21.88 13.93 13 65829 606 42554887
Gastrointestinal wall thickening 21.88 13.93 20 65822 1819 42553674
Cataract 21.75 13.93 10 65832 30594 42524899
Metastases to bone 21.71 13.93 61 65781 14748 42540745
Clonal haematopoiesis 21.70 13.93 9 65833 190 42555303
Liver injury 21.64 13.93 72 65770 19076 42536417
Varices oesophageal 21.53 13.93 30 65812 4335 42551158
Pulmonary hypertension 21.49 13.93 5 65837 23564 42531929
Haematemesis 21.41 13.93 98 65744 30101 42525392
Alanine aminotransferase increased 21.19 13.93 68 65774 88338 42467155
Obstructive airways disorder 21.14 13.93 6 65836 24753 42530740
Erythema 21.14 13.93 259 65583 108534 42446959
Parathyroid tumour malignant 21.05 13.93 7 65835 77 42555416
Necrotising oesophagitis 21.04 13.93 15 65827 956 42554537
Skin hyperpigmentation 21.02 13.93 29 65813 4152 42551341
Eosinophilic pneumonia chronic 20.96 13.93 10 65832 297 42555196
Peripheral sensorimotor neuropathy 20.81 13.93 20 65822 1938 42553555
Pharyngeal ulceration 20.74 13.93 11 65831 411 42555082
Phimosis 20.69 13.93 16 65826 1155 42554338
Adenocarcinoma metastatic 20.65 13.93 7 65835 82 42555411
Onycholysis 20.58 13.93 15 65827 990 42554503
Peritoneal disorder 20.48 13.93 10 65832 313 42555180
Productive cough 20.38 13.93 30 65812 51537 42503956
Cognitive disorder 20.22 13.93 14 65828 34158 42521335
Incisional hernia 19.99 13.93 17 65825 1405 42554088
Pallor 19.68 13.93 10 65832 28876 42526617
Aortic dissection 19.65 13.93 24 65818 3048 42552445
Cholangitis 19.63 13.93 48 65794 10679 42544814
Liver ablation 19.56 13.93 5 65837 19 42555474
Neutropenic colitis 19.52 13.93 29 65813 4441 42551052
Ileus paralytic 19.42 13.93 39 65803 7602 42547891
Metastases to adrenals 19.34 13.93 15 65827 1087 42554406
Product use issue 19.12 13.93 58 65784 76693 42478800
Nail bed inflammation 19.07 13.93 8 65834 174 42555319
Hepatic infarction 19.06 13.93 9 65833 261 42555232
Oxygen saturation decreased 19.05 13.93 45 65797 64642 42490851
Dyspnoea exertional 19.03 13.93 30 65812 50118 42505375
Ectropion 19.03 13.93 8 65834 175 42555318
Change of bowel habit 19.02 13.93 15 65827 1114 42554379
Gastrointestinal inflammation 18.93 13.93 29 65813 4563 42550930
Influenza like illness 18.90 13.93 13 65829 31827 42523666
Incorrect dose administered 18.88 13.93 33 65809 52941 42502552
Penile ulceration 18.80 13.93 13 65829 789 42554704
Traumatic ulcer 18.79 13.93 5 65837 23 42555470
Tenderness 18.71 13.93 42 65800 8841 42546652
Infusion site hypoaesthesia 18.66 13.93 4 65838 5 42555488
Xeroderma 18.62 13.93 8 65834 185 42555308
Oropharyngeal pain 18.55 13.93 23 65819 42487 42513006
Autoimmune hypothyroidism 18.54 13.93 8 65834 187 42555306
Angioedema 18.52 13.93 23 65819 42454 42513039
Anterior spinal artery syndrome 18.24 13.93 4 65838 6 42555487
Eczema impetiginous 18.13 13.93 5 65837 27 42555466
Faeces pale 18.13 13.93 17 65825 1597 42553896
Respiratory tract infection 18.10 13.93 9 65833 26313 42529180
Hot flush 18.03 13.93 6 65836 22345 42533148
Angina pectoris 17.86 13.93 99 65743 32797 42522696
Scleroderma-like reaction 17.80 13.93 6 65836 69 42555424
Tremor 17.80 13.93 83 65759 96846 42458647
Peripheral embolism 17.79 13.93 14 65828 1037 42554456
Eye infection gonococcal 17.69 13.93 5 65837 30 42555463
Therapeutic product effect prolonged 17.66 13.93 9 65833 309 42555184
Depressed mood 17.64 13.93 7 65835 23377 42532116
Feeling cold 17.63 13.93 52 65790 12921 42542572
Eczema 17.61 13.93 16 65826 34070 42521423
Vasospasm 17.38 13.93 11 65831 575 42554918
Osteoarthritis 17.31 13.93 8 65834 24397 42531096
Depressed level of consciousness 16.99 13.93 30 65812 47940 42507553
Urinary tract toxicity 16.91 13.93 5 65837 36 42555457
Pelvic fluid collection 16.79 13.93 8 65834 237 42555256
Laryngeal discomfort 16.76 13.93 8 65834 238 42555255
Metastases to the mediastinum 16.73 13.93 9 65833 346 42555147
Gastrointestinal oedema 16.71 13.93 17 65825 1764 42553729
Balance disorder 16.69 13.93 30 65812 47615 42507878
Mobility decreased 16.60 13.93 18 65824 35288 42520205
Gastrointestinal mucosal disorder 16.47 13.93 10 65832 485 42555008
Colorectostomy 16.42 13.93 3 65839 0 42555493
Urethral ulcer 16.42 13.93 3 65839 0 42555493
Scrotal ulcer 16.36 13.93 10 65832 491 42555002
Hyperammonaemia 16.35 13.93 37 65805 7829 42547664
Perforation 16.27 13.93 10 65832 496 42554997
Fluid retention 16.15 13.93 15 65827 31604 42523889
Pancreatic carcinoma metastatic 15.97 13.93 22 65820 3144 42552349
Extrapyramidal disorder 15.95 13.93 3 65839 16409 42539084
Rash pruritic 15.94 13.93 17 65825 33586 42521907
Abortion induced 15.93 13.93 7 65835 171 42555322
Metastatic neoplasm 15.91 13.93 23 65819 3438 42552055
Blood lactic acid increased 15.82 13.93 37 65805 8002 42547491
Carbohydrate antigen 19-9 increased 15.80 13.93 8 65834 271 42555222
Heart rate increased 15.72 13.93 37 65805 53218 42502275
False negative investigation result 15.67 13.93 8 65834 276 42555217
Sensitisation 15.61 13.93 8 65834 278 42555215
Dyskinesia 15.56 13.93 10 65832 25380 42530113
Hepatic function abnormal 15.37 13.93 134 65708 51433 42504060
Acral peeling skin syndrome 15.37 13.93 5 65837 51 42555442
Metastases to meninges 15.35 13.93 17 65825 1944 42553549
Vision blurred 15.30 13.93 38 65804 53661 42501832
Electromyogram abnormal 15.28 13.93 5 65837 52 42555441
Chronic myeloid leukaemia 15.18 13.93 19 65823 2473 42553020
Metastases to pelvis 15.16 13.93 9 65833 419 42555074
Neutrophilia 15.13 13.93 29 65813 5463 42550030
Perineal ulceration 15.11 13.93 4 65838 18 42555475
Xanthoma 15.10 13.93 6 65836 113 42555380
Respiratory arrest 15.09 13.93 13 65829 28411 42527082
Hypotension 15.04 13.93 294 65548 257337 42298156
Dysentery 14.93 13.93 9 65833 431 42555062
Urinary tract infection 14.90 13.93 91 65751 99193 42456300
Cholecystitis 14.82 13.93 49 65793 12939 42542554
Restlessness 14.79 13.93 14 65828 29235 42526258
Blood cholesterol increased 14.48 13.93 12 65830 26729 42528764
Lymphocyte count decreased 14.43 13.93 13 65829 27796 42527697
Medication error 14.40 13.93 18 65824 33136 42522357
Portal vein pressure increased 14.35 13.93 3 65839 3 42555490
Hypervolaemia 14.32 13.93 9 65833 23116 42532377
Intestinal transit time abnormal 14.30 13.93 4 65838 23 42555470
Swelling of eyelid 14.22 13.93 17 65825 2111 42553382
Head injury 14.21 13.93 7 65835 20575 42534918
Duodenal perforation 14.17 13.93 15 65827 1631 42553862
No adverse event 14.13 13.93 106 65736 38915 42516578
Adenocarcinoma of colon 14.07 13.93 23 65819 3824 42551669
Lung neoplasm malignant 14.01 13.93 6 65836 19141 42536352
Renal vein thrombosis 14.01 13.93 9 65833 483 42555010
Anastomotic haemorrhage 13.99 13.93 7 65835 231 42555262
COVID-19 pneumonia 13.96 13.93 8 65834 21605 42533888
Urethritis 13.96 13.93 9 65833 486 42555007

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Palmar-plantar erythrodysaesthesia syndrome 9149.46 13.25 3065 154971 37960 110393303
Disease progression 4134.27 13.25 3140 154896 240894 110190369
Diarrhoea 3571.18 13.25 6042 151994 1133463 109297800
Malignant neoplasm progression 1841.76 13.25 1712 156324 172855 110258408
Metastases to liver 1464.15 13.25 801 157235 34585 110396678
Mucosal inflammation 1370.51 13.25 1120 156916 95021 110336242
Neuropathy peripheral 1308.49 13.25 1441 156595 177836 110253427
Arteriospasm coronary 1172.60 13.25 454 157582 8646 110422617
Myelosuppression 1101.06 13.25 980 157056 93360 110337903
Metastases to bone 1080.88 13.25 630 157406 30742 110400521
Metastases to lung 926.15 13.25 512 157524 22551 110408712
Metastases to central nervous system 914.78 13.25 506 157530 22311 110408952
Death 777.73 13.25 2476 155560 696393 109734870
Nausea 700.85 13.25 3544 154492 1232146 109199117
Neutropenia 655.78 13.25 1568 156468 373052 110058211
Neoplasm progression 623.72 13.25 604 157432 63991 110367272
Vomiting 623.16 13.25 2760 155276 907915 109523348
Breast cancer metastatic 601.88 13.25 302 157734 10879 110420384
Neurotoxicity 549.67 13.25 467 157569 41740 110389523
Dehydration 532.60 13.25 1210 156826 278301 110152962
Gastrointestinal toxicity 530.19 13.25 277 157759 10871 110420392
Metastases to lymph nodes 517.99 13.25 302 157734 14730 110416533
Enteritis 514.22 13.25 328 157708 18828 110412435
Thrombocytopenia 462.99 13.25 1317 156719 347568 110083695
Cardiotoxicity 445.56 13.25 286 157750 16595 110414668
Rheumatoid arthritis 410.85 13.25 3 158033 299610 110131653
Skin toxicity 409.36 13.25 238 157798 11545 110419718
Bone marrow failure 400.69 13.25 453 157583 57395 110373868
Arthralgia 390.70 13.25 325 157711 779307 109651956
Joint swelling 388.36 13.25 80 157956 442765 109988498
Enterocolitis 380.48 13.25 271 157765 18678 110412585
Dihydropyrimidine dehydrogenase deficiency 376.07 13.25 82 157954 134 110431129
Decreased appetite 356.96 13.25 1485 156551 474361 109956902
Completed suicide 329.50 13.25 3 158033 242378 110188885
Condition aggravated 329.43 13.25 339 157697 734497 109696766
Systemic lupus erythematosus 325.33 13.25 8 158028 254330 110176933
Stomatitis 295.96 13.25 954 157082 269288 110161975
Arthropathy 290.12 13.25 35 158001 287487 110143776
Skin fissures 271.09 13.25 247 157789 24211 110407052
Laryngospasm 268.75 13.25 132 157904 4536 110426727
Maternal exposure during pregnancy 264.76 13.25 28 158008 254855 110176408
Contraindicated product administered 261.18 13.25 26 158010 248241 110183022
Metastases to skin 255.18 13.25 103 157933 2196 110429067
Metastases to peritoneum 254.27 13.25 135 157901 5475 110425788
Asthenia 240.64 13.25 1746 156290 687253 109744010
Glossodynia 239.51 13.25 21 158015 221983 110209280
Helicobacter infection 239.42 13.25 4 158032 181873 110249390
Paronychia 235.28 13.25 164 157872 10917 110420346
Therapeutic product effect decreased 233.95 13.25 35 158001 244281 110186982
Tumour marker increased 230.00 13.25 122 157914 4938 110426325
Anastomotic leak 227.30 13.25 82 157954 1270 110429993
Gastrointestinal perforation 226.16 13.25 138 157898 7318 110423945
Drug abuse 225.26 13.25 6 158030 177405 110253858
Haematotoxicity 224.11 13.25 208 157828 20874 110410389
Musculoskeletal stiffness 218.97 13.25 64 157972 279758 110151505
Duodenal ulcer perforation 215.07 13.25 9 158027 177691 110253572
Wound 214.59 13.25 38 157998 234399 110196864
Sinusitis 212.62 13.25 79 157957 296609 110134654
Skin exfoliation 212.48 13.25 419 157617 87232 110344031
Hyperbilirubinaemia 212.03 13.25 240 157796 30431 110400832
Drug ineffective 211.71 13.25 1292 156744 1519248 108912015
Drug hypersensitivity 210.64 13.25 203 157833 453887 109977376
Fibromyalgia 209.06 13.25 8 158028 170901 110260362
Therapy cessation 204.48 13.25 285 157751 44572 110386691
Therapy partial responder 203.61 13.25 258 157778 36803 110394460
Irritable bowel syndrome 203.25 13.25 7 158029 164208 110267055
Intestinal obstruction 200.38 13.25 309 157727 52918 110378345
Osteonecrosis of jaw 198.20 13.25 291 157745 47726 110383537
Pericarditis 197.34 13.25 37 157999 219077 110212186
Depression 195.25 13.25 105 157931 317230 110114033
Asthma 192.63 13.25 59 157977 250232 110181031
Weight increased 191.84 13.25 190 157846 419454 110011809
Metastasis 191.24 13.25 129 157907 8138 110423125
Ascites 189.01 13.25 413 157623 92395 110338868
Tumour perforation 187.32 13.25 59 157977 586 110430677
Carcinoembryonic antigen increased 187.29 13.25 88 157948 2736 110428527
Muscle injury 185.73 13.25 3 158033 140804 110290459
Urticaria 185.47 13.25 113 157923 318744 110112519
Wheezing 182.80 13.25 68 157968 255162 110176101
Fall 177.53 13.25 373 157663 603109 109828154
Osteoarthritis 177.51 13.25 25 158011 182598 110248665
Exposure during pregnancy 177.46 13.25 17 158019 167407 110263856
Mobility decreased 177.33 13.25 59 157977 237363 110193900
Hypokalaemia 176.48 13.25 618 157418 181830 110249433
Hospice care 174.73 13.25 144 157892 12329 110418934
Pseudocirrhosis 170.38 13.25 60 157976 863 110430400
Ejection fraction decreased 169.09 13.25 248 157788 40632 110390631
Portal hypertension 167.59 13.25 121 157915 8516 110422747
Swelling 167.35 13.25 153 157883 350888 110080375
Treatment failure 165.81 13.25 95 157941 277139 110154124
Skin discolouration 163.01 13.25 269 157767 48777 110382486
Headache 159.63 13.25 684 157352 881693 109549570
Injury 159.47 13.25 30 158006 177235 110254028
Pruritus 158.31 13.25 375 157661 581185 109850078
Folliculitis 158.23 13.25 25 158011 167628 110263635
Colitis 158.13 13.25 409 157627 101914 110329349
Psoriasis 157.26 13.25 11 158025 139982 110291281
Leukopenia 157.06 13.25 519 157517 148272 110282991
Non-cirrhotic portal hypertension 155.46 13.25 53 157983 688 110430575
Breast cancer recurrent 153.30 13.25 85 157951 3761 110427502
Type 2 diabetes mellitus 153.17 13.25 33 158003 177199 110254064
Dysaesthesia pharynx 150.39 13.25 41 157995 231 110431032
Fingerprint loss 146.74 13.25 33 158003 67 110431196
Lower respiratory tract infection 144.37 13.25 84 157952 243022 110188241
Intentional overdose 144.34 13.25 12 158024 132489 110298774
Overdose 141.39 13.25 79 157957 233715 110197548
Hepatic enzyme increased 141.25 13.25 150 157886 320742 110110521
Breast cancer 141.23 13.25 221 157815 38321 110392942
Nasopharyngitis 137.94 13.25 219 157817 394142 110037121
Polyneuropathy 137.92 13.25 198 157838 31814 110399449
Gastrointestinal injury 137.72 13.25 63 157973 1840 110429423
Hepatic function abnormal 134.97 13.25 354 157682 88941 110342322
Drug interaction 134.91 13.25 324 157712 499859 109931404
Joint range of motion decreased 132.81 13.25 11 158025 121821 110309442
Stomal varices 132.14 13.25 33 158003 123 110431140
Hepatic lesion 131.57 13.25 104 157932 8389 110422874
Product use issue 131.36 13.25 151 157885 311544 110119719
Platelet count decreased 130.61 13.25 663 157373 229780 110201483
Bursitis 130.53 13.25 16 158020 129902 110301361
Blood bilirubin increased 130.31 13.25 316 157720 75656 110355607
Discomfort 129.18 13.25 73 157963 214634 110216629
Blood cholesterol increased 127.71 13.25 52 157984 184733 110246530
Metastases to pleura 126.77 13.25 61 157975 2002 110429261
Abdominal discomfort 126.46 13.25 231 157805 393627 110037636
Infusion related reaction 122.87 13.25 223 157813 380939 110050324
Arthritis 122.77 13.25 43 157993 167543 110263720
Obesity 121.47 13.25 11 158025 113340 110317923
Abdominal pain 120.73 13.25 1191 156845 511798 109919465
Pneumonia 120.39 13.25 747 157289 875967 109555296
Dry skin 120.35 13.25 383 157653 107270 110323993
Onycholysis 120.24 13.25 65 157971 2734 110428529
Lymphangiosis carcinomatosa 118.94 13.25 62 157974 2420 110428843
Metastases to meninges 118.57 13.25 80 157956 5048 110426215
Confusional state 118.30 13.25 314 157722 468366 109962897
Hepatic failure 115.85 13.25 284 157752 68455 110362808
Fatigue 115.74 13.25 2405 155631 1213553 109217710
Anastomotic complication 113.86 13.25 40 157996 571 110430692
PIK3CA-activated mutation 113.82 13.25 41 157995 632 110430631
Pain 113.10 13.25 850 157186 954105 109477158
Paraesthesia 111.72 13.25 727 157309 275794 110155469
Prescribed overdose 111.01 13.25 3 158033 87578 110343685
Suicide attempt 110.88 13.25 10 158026 103384 110327879
Terminal ileitis 110.21 13.25 52 157984 1632 110429631
Carbohydrate antigen 15-3 increased 110.04 13.25 51 157985 1536 110429727
Ileus 109.54 13.25 174 157862 30555 110400708
Hypovolaemic shock 109.20 13.25 119 157917 14464 110416799
Product dose omission issue 107.55 13.25 184 157852 321598 110109665
Acute promyelocytic leukaemia 107.32 13.25 53 157983 1843 110429420
Migraine 105.22 13.25 57 157979 171595 110259668
Anxiety 104.97 13.25 209 157827 344869 110086394
Toxic leukoencephalopathy 102.98 13.25 49 157987 1568 110429695
Gastrointestinal anastomotic leak 101.40 13.25 39 157997 728 110430535
Influenza 100.99 13.25 58 157978 169043 110262220
Hypertriglyceridaemia 100.91 13.25 120 157916 16034 110415229
Recall phenomenon 100.35 13.25 46 157990 1350 110429913
Hypoalbuminaemia 99.09 13.25 161 157875 28813 110402450
Neutrophil count decreased 97.94 13.25 387 157649 120554 110310709
Sleep disorder 97.71 13.25 84 157952 198560 110232703
Sciatica 96.28 13.25 10 158026 92389 110338874
Intentional product misuse 95.81 13.25 35 158001 132869 110298394
Skin hyperpigmentation 94.75 13.25 87 157949 8609 110422654
Performance status decreased 93.74 13.25 80 157956 7186 110424077
Insomnia 92.92 13.25 239 157797 360351 110070912
Dysphagia 92.00 13.25 449 157587 153151 110278112
Metastatic neoplasm 91.16 13.25 72 157964 5801 110425462
Intestinal perforation 90.89 13.25 130 157906 20814 110410449
Subacute cutaneous lupus erythematosus 90.19 13.25 67 157969 4927 110426336
Lip dry 89.87 13.25 17 158019 100066 110331197
Proteinuria 89.43 13.25 185 157851 39833 110391430
Reactive capillary endothelial proliferation 88.32 13.25 19 158017 28 110431235
Peripheral sensory neuropathy 86.71 13.25 113 157923 16567 110414696
Nasal congestion 85.52 13.25 18 158018 98264 110332999
Pulmonary embolism 85.45 13.25 562 157474 213912 110217351
Bronchitis 85.34 13.25 60 157976 156972 110274291
Gastric perforation 84.29 13.25 64 157972 4865 110426398
Contusion 84.01 13.25 127 157909 233234 110198029
Bradycardia 82.46 13.25 61 157975 155456 110275807
Venoocclusive liver disease 82.15 13.25 105 157931 15102 110416161
Loss of personal independence in daily activities 81.95 13.25 57 157979 149963 110281300
Hiccups 81.05 13.25 96 157940 12773 110418490
Pleural effusion 80.98 13.25 482 157554 177227 110254036
Injection site pain 80.70 13.25 81 157955 177841 110253422
Colon cancer metastatic 80.26 13.25 48 157988 2453 110428810
Metastases to spine 79.72 13.25 64 157972 5279 110425984
Recurrent cancer 78.19 13.25 53 157983 3370 110427893
Suicidal ideation 78.13 13.25 19 158017 93918 110337345
Dysaesthesia 77.53 13.25 70 157966 6777 110424486
Night sweats 77.12 13.25 48 157988 133935 110297328
Mucosal toxicity 76.19 13.25 31 158005 675 110430588
Cardiac failure congestive 75.30 13.25 63 157973 150937 110280326
Chronic obstructive pulmonary disease 74.95 13.25 31 158005 109127 110322136
Prinzmetal angina 73.99 13.25 44 157992 2225 110429038
Prescribed underdose 73.54 13.25 5 158031 65169 110366094
Peritonitis 73.17 13.25 151 157885 32456 110398807
Lung disorder 72.85 13.25 90 157946 179957 110251306
Varices oesophageal 72.49 13.25 69 157967 7146 110424117
Memory impairment 72.03 13.25 106 157930 196838 110234425
Osteonecrosis 71.93 13.25 153 157883 33588 110397675
Acute coronary syndrome 71.78 13.25 123 157913 22989 110408274
Infusion site coldness 70.67 13.25 23 158013 256 110431007
Dermatitis acneiform 69.12 13.25 88 157948 12607 110418656
Mouth ulceration 68.84 13.25 187 157849 47951 110383312
Bone lesion 67.85 13.25 66 157970 7021 110424242
Plasma cell myeloma 67.72 13.25 6 158030 62930 110368333
Electrocardiogram ST segment elevation 67.29 13.25 74 157962 9086 110422177
Metastases to chest wall 67.24 13.25 28 158008 648 110430615
Leukoencephalopathy 67.05 13.25 74 157962 9121 110422142
Oesophagitis 66.83 13.25 135 157901 28580 110402683
Metastases to the mediastinum 66.16 13.25 29 158007 764 110430499
Blepharospasm 65.61 13.25 3 158033 54848 110376415
Blood pressure fluctuation 64.49 13.25 14 158022 74810 110356453
Hyperammonaemic encephalopathy 64.40 13.25 57 157979 5377 110425886
Wound dehiscence 63.18 13.25 67 157969 7895 110423368
Nail bed inflammation 62.66 13.25 38 157998 1992 110429271
Gamma-glutamyltransferase decreased 62.50 13.25 23 158013 378 110430885
Nodular regenerative hyperplasia 62.16 13.25 35 158001 1596 110429667
Subileus 61.72 13.25 60 157976 6377 110424886
Disseminated intravascular coagulation 61.68 13.25 163 157873 41123 110390140
Peripheral swelling 60.75 13.25 334 157702 403700 110027563
Pharyngeal inflammation 60.54 13.25 35 158001 1679 110429584
Rhabdomyolysis 60.31 13.25 50 157986 120351 110310912
Drug reaction with eosinophilia and systemic symptoms 60.22 13.25 21 158015 82074 110349189
Ear infection 59.98 13.25 9 158027 62723 110368540
Congestive cardiomyopathy 59.86 13.25 87 157949 14132 110417131
Device related thrombosis 59.30 13.25 45 157991 3417 110427846
Inflammation 58.75 13.25 117 157919 193121 110238142
Metastases to eye 58.70 13.25 21 158015 317 110430946
Ventricular fibrillation 58.59 13.25 160 157876 41153 110390110
Cheilitis 58.56 13.25 58 157978 6307 110424956
Road traffic accident 58.40 13.25 41 157995 107357 110323906
Pneumonitis 58.05 13.25 240 157796 76291 110354972
Grip strength decreased 57.97 13.25 21 158015 80153 110351110
COVID-19 57.44 13.25 170 157866 244890 110186373
Azotaemia 56.64 13.25 71 157965 10014 110421249
Osteoporosis 56.30 13.25 27 158009 87125 110344138
Neutropenic sepsis 56.07 13.25 131 157905 30615 110400648
White blood cell count decreased 56.00 13.25 537 157499 228853 110202410
Drug dependence 55.96 13.25 4 158032 50016 110381247
Dermatoglyphic anomaly 55.52 13.25 10 158026 0 110431263
Disease recurrence 55.38 13.25 202 157834 60582 110370681
Vascular pain 55.35 13.25 29 158007 1144 110430119
Feeling abnormal 55.30 13.25 109 157927 180602 110250661
Cytokine release syndrome 55.10 13.25 16 158020 70290 110360973
Medication error 54.99 13.25 42 157994 105324 110325939
Stridor 54.67 13.25 58 157978 6837 110424426
Hypercholesterolaemia 54.45 13.25 31 158005 90806 110340457
Pneumatosis intestinalis 54.34 13.25 64 157972 8465 110422798
Delirium 54.08 13.25 68 157968 134957 110296306
Foot deformity 53.89 13.25 4 158032 48476 110382787
Hypersensitivity 53.33 13.25 348 157688 403650 110027613
Small intestinal obstruction 53.11 13.25 132 157904 32081 110399182
Focal nodular hyperplasia 53.10 13.25 26 158010 887 110430376
Sedation 52.55 13.25 17 158019 69666 110361597
Back injury 52.43 13.25 4 158032 47395 110383868
Wrong technique in product usage process 52.08 13.25 30 158006 87318 110343945
Cytomegalovirus infection 51.62 13.25 8 158028 54436 110376827
Nail discolouration 50.98 13.25 42 157994 3593 110427670
Therapy change 50.84 13.25 67 157969 9930 110421333
Constipation 50.76 13.25 755 157281 357031 110074232
Jaundice 50.75 13.25 193 157843 59043 110372220
Obstruction gastric 50.43 13.25 33 158003 1978 110429285
Lacrimation increased 50.16 13.25 126 157910 30824 110400439
Arterial thrombosis 50.05 13.25 39 157997 3080 110428183
Biliary obstruction 49.94 13.25 50 157986 5508 110425755
Colorectal cancer metastatic 49.71 13.25 30 158006 1559 110429704
Metastases to breast 49.33 13.25 19 158017 356 110430907
Somnolence 49.14 13.25 238 157798 297211 110134052
Upper respiratory tract infection 48.68 13.25 70 157966 131258 110300005
Lactic acidosis 48.42 13.25 37 157999 92774 110338489
Portal vein thrombosis 48.38 13.25 55 157981 7003 110424260
Product quality issue 48.34 13.25 25 158011 77274 110353989
Gait inability 48.31 13.25 75 157961 136301 110294962
Pregnancy 47.30 13.25 8 158028 51059 110380204
Hypophagia 47.19 13.25 174 157862 52452 110378811
Impaired healing 47.16 13.25 135 157901 196582 110234681
Oesophageal haemorrhage 47.16 13.25 31 158005 1872 110429391
Angina pectoris 46.96 13.25 195 157841 62100 110369163
Rectal tenesmus 46.90 13.25 33 158003 2229 110429034
Lymphadenopathy 46.70 13.25 198 157838 63637 110367626
Amnesia 46.64 13.25 49 157987 105359 110325904
Bone disorder 46.22 13.25 97 157939 21095 110410168
Cold dysaesthesia 45.99 13.25 10 158026 16 110431247
Thrombosis 45.86 13.25 289 157747 108373 110322890
Abdominal lymphadenopathy 45.84 13.25 30 158006 1798 110429465
Mucosal disorder 45.82 13.25 43 157993 4374 110426889
Lymphoedema 45.77 13.25 79 157957 14850 110416413
Pyogenic granuloma 45.77 13.25 20 158016 523 110430740
Aortic thrombosis 45.62 13.25 32 158004 2151 110429112
Neck pain 45.28 13.25 66 157970 123064 110308199
Drug level increased 45.27 13.25 7 158029 47712 110383551
Musculoskeletal pain 45.06 13.25 124 157912 182899 110248364
Basal cell carcinoma 44.44 13.25 6 158030 45264 110385999
Metastases to adrenals 44.39 13.25 28 158008 1575 110429688
Anastomotic fistula 44.36 13.25 14 158022 140 110431123
Splenorenal shunt 44.24 13.25 10 158026 21 110431242
Hand-foot-genital syndrome 44.24 13.25 10 158026 21 110431242
Agitation 44.17 13.25 58 157978 112993 110318270
Erythema 44.10 13.25 622 157414 290825 110140438
Eosinophilia 43.93 13.25 14 158022 57922 110373341
Injection site erythema 43.70 13.25 42 157994 94134 110337129
Pigmentation disorder 43.52 13.25 53 157983 7258 110424005
Jaw operation 43.09 13.25 22 158014 822 110430441
X-ray abnormal 42.78 13.25 3 158033 38114 110393149
Epistaxis 42.77 13.25 326 157710 130046 110301217
Dizziness 42.77 13.25 721 157315 697472 109733791
Nasal mucosal disorder 42.64 13.25 29 158007 1854 110429409
Electrolyte imbalance 42.52 13.25 133 157903 36895 110394368
Large intestine perforation 42.10 13.25 81 157955 16548 110414715
Hemianopia 42.04 13.25 34 158002 2834 110428429
Acute myeloid leukaemia 42.03 13.25 135 157901 37975 110393288
Hepatic atrophy 41.75 13.25 18 158018 455 110430808
Anaemia 41.72 13.25 1050 156986 546036 109885227
Fluid retention 41.54 13.25 44 157992 94263 110337000
Dysgeusia 41.47 13.25 204 157832 69781 110361482
Tumour pain 41.02 13.25 34 158002 2933 110428330
Neutropenic colitis 40.93 13.25 54 157982 8011 110423252
Exostosis 40.84 13.25 8 158028 45948 110385315
Treatment noncompliance 40.83 13.25 27 158009 72963 110358300
Coronary artery disease 40.81 13.25 26 158010 71664 110359599
Streptococcal sepsis 40.81 13.25 43 157993 5029 110426234
Hallucination 40.71 13.25 51 157985 101381 110329882
Adverse event 40.33 13.25 58 157978 108751 110322512
Bone pain 40.13 13.25 192 157844 64941 110366322
Therapy interrupted 39.97 13.25 159 157877 49663 110381600
Necrotising oesophagitis 39.50 13.25 26 158010 1574 110429689
Coeliac disease 39.49 13.25 7 158029 43180 110388083
Pulmonary sarcoidosis 39.44 13.25 27 158009 1745 110429518
Bone erosion 39.31 13.25 9 158027 46362 110384901
Hypotension 38.93 13.25 521 157515 523328 109907935
Prothrombin level decreased 38.92 13.25 27 158009 1783 110429480
Weight decreased 38.89 13.25 909 157127 467148 109964115
Rectal perforation 38.83 13.25 22 158014 1015 110430248
Cachexia 38.80 13.25 68 157968 12937 110418326
Necrotising fasciitis 38.79 13.25 51 157985 7540 110423723
Diaphragmatic spasm 38.76 13.25 12 158024 112 110431151
Sepsis 38.62 13.25 670 157366 326676 110104587
Stoma site haemorrhage 38.52 13.25 30 158006 2368 110428895
Drug intolerance 38.50 13.25 383 157653 406129 110025134
Aortic dissection 38.24 13.25 41 157995 4892 110426371
Sleep apnoea syndrome 38.22 13.25 6 158030 40441 110390822
Oxygen saturation decreased 38.16 13.25 107 157929 156875 110274388
Metastases to ovary 37.88 13.25 16 158020 384 110430879
Myalgia 37.85 13.25 176 157860 222205 110209058
Dry mouth 37.85 13.25 152 157884 199796 110231467
Chronic kidney disease 37.82 13.25 32 158004 76259 110355004
Protein urine 37.72 13.25 25 158011 1531 110429732
Stress cardiomyopathy 37.60 13.25 75 157961 15731 110415532
Joint dislocation 37.49 13.25 3 158033 34187 110397076
Portal shunt 37.48 13.25 11 158025 84 110431179
Malignant ascites 37.48 13.25 24 158012 1386 110429877
Pulmonary hypertension 37.39 13.25 16 158020 55204 110376059
Neoplasm malignant 36.89 13.25 127 157909 37016 110394247
Hand-foot-and-mouth disease 36.46 13.25 19 158017 741 110430522
Therapeutic product effect incomplete 36.42 13.25 180 157856 223625 110207638
Abnormal behaviour 36.42 13.25 6 158030 39033 110392230
Blood pressure systolic increased 36.24 13.25 39 157997 82952 110348311
Biliary sepsis 36.17 13.25 26 158010 1817 110429446
Subclavian vein thrombosis 36.17 13.25 31 158005 2801 110428462
Wound infection 36.16 13.25 51 157985 96414 110334849
Device occlusion 36.06 13.25 72 157964 15113 110416150
Angioedema 36.02 13.25 53 157983 98447 110332816
Acute motor axonal neuropathy 35.68 13.25 12 158024 149 110431114
Infusion site induration 35.53 13.25 23 158013 1353 110429910
Incorrect route of product administration 35.43 13.25 24 158012 64037 110367226
Obstructive airways disorder 35.26 13.25 11 158025 46138 110385125
Tooth extraction 35.03 13.25 65 157971 12926 110418337
Abortion spontaneous 34.98 13.25 4 158032 34278 110396985
Adnexa uteri mass 34.95 13.25 16 158020 468 110430795
Hyperammonaemia 34.90 13.25 67 157969 13665 110417598
HER2 positive breast cancer 34.84 13.25 15 158021 378 110430885
Incorrect dose administered 34.83 13.25 59 157977 103582 110327681
Accidental exposure to product 34.65 13.25 14 158022 49994 110381269
Disturbance in attention 34.59 13.25 23 158013 61972 110369291
Neoplasm recurrence 34.56 13.25 40 157996 5192 110426071
Failure to anastomose 34.49 13.25 13 158023 229 110431034
C-reactive protein increased 34.47 13.25 177 157859 217742 110213521
Pancytopenia 34.41 13.25 454 157582 209159 110222104
Muscular weakness 34.32 13.25 211 157825 248257 110183006
Proteus infection 34.18 13.25 30 158006 2798 110428465
Pancreatitis viral 34.15 13.25 8 158028 21 110431242
Therapy non-responder 34.11 13.25 113 157923 157194 110274069
Xeroderma 34.03 13.25 17 158019 606 110430657
Pulmonary mass 34.01 13.25 124 157912 37177 110394086
Nervousness 33.64 13.25 6 158030 36845 110394418
Ectropion 33.57 13.25 16 158020 514 110430749
Interstitial lung disease 33.40 13.25 325 157711 139009 110292254
Protein-losing gastroenteropathy 33.33 13.25 19 158017 887 110430376
Device issue 32.91 13.25 5 158031 34530 110396733
Cholangitis 32.45 13.25 72 157964 16263 110415000
Hyperchylomicronaemia 31.99 13.25 9 158027 58 110431205
Tumour necrosis 31.79 13.25 27 158009 2409 110428854
Respiratory disorder 31.78 13.25 33 158003 71349 110359914
Depressed level of consciousness 31.59 13.25 71 157965 112207 110319056
Pancreatic neuroendocrine tumour metastatic 31.55 13.25 12 158024 217 110431046
Gastrointestinal inflammation 31.54 13.25 52 157984 9417 110421846
Blood uric acid decreased 31.47 13.25 22 158014 1471 110429792
Haemophagocytic lymphohistiocytosis 31.41 13.25 4 158032 31555 110399708
Plantar erythema 31.37 13.25 13 158023 297 110430966
Rhinorrhoea 31.33 13.25 62 157974 102604 110328659
Asthenopia 31.29 13.25 30 158006 3134 110428129
Debridement 31.21 13.25 24 158012 1859 110429404
Metastases to abdominal cavity 31.20 13.25 18 158018 860 110430403
Psychotic disorder 31.08 13.25 17 158019 50920 110380343
Pelvic fluid collection 31.02 13.25 19 158017 1014 110430249
Acute kidney injury 30.98 13.25 682 157354 634748 109796515
Hypermutation 30.83 13.25 10 158026 110 110431153
Granulocyte count decreased 30.75 13.25 33 158003 3941 110427322
Balanoposthitis 30.70 13.25 21 158015 1355 110429908
Peripheral ischaemia 30.66 13.25 56 157980 11002 110420261
Prostate cancer 30.55 13.25 8 158028 37633 110393630
Respiratory tract congestion 30.50 13.25 4 158032 30853 110400410
Left ventricular dysfunction 30.38 13.25 88 157948 23405 110407858
Eosinophil percentage increased 30.32 13.25 22 158014 1560 110429703
Induration 30.20 13.25 26 158010 2363 110428900
Hepatotoxicity 30.17 13.25 174 157862 63226 110368037
Carbohydrate antigen 19-9 increased 29.87 13.25 15 158021 541 110430722
Joint injury 29.73 13.25 10 158026 39984 110391279
Steatohepatitis 29.60 13.25 20 158016 1265 110429998
Peritoneal disorder 29.53 13.25 17 158019 809 110430454
Hormone receptor positive breast cancer 29.34 13.25 15 158021 562 110430701
Colon cancer recurrent 29.32 13.25 10 158026 130 110431133
Nail infection 29.29 13.25 26 158010 2462 110428801
Aggression 29.14 13.25 25 158011 59185 110372078
Pulmonary fibrosis 29.14 13.25 64 157972 101978 110329285
Metastases to pelvis 29.04 13.25 17 158019 835 110430428
Odynophagia 28.97 13.25 63 157973 14038 110417225
Drug ineffective for unapproved indication 28.96 13.25 65 157971 102773 110328490
Tumour fistulisation 28.91 13.25 10 158026 136 110431127
Withdrawal syndrome 28.88 13.25 5 158031 31375 110399888
Blood creatinine decreased 28.86 13.25 49 157987 9088 110422175
Product use in unapproved indication 28.66 13.25 458 157578 446919 109984344
Clostridial infection 28.65 13.25 40 157996 6262 110425001
Oedema 28.64 13.25 179 157857 209797 110221466
Intestinal ischaemia 28.49 13.25 68 157968 16111 110415152
Angina bullosa haemorrhagica 28.47 13.25 11 158025 208 110431055
Gastrointestinal stoma necrosis 28.26 13.25 7 158029 25 110431238
Ataxia 28.22 13.25 101 157935 30007 110401256
Early satiety 28.20 13.25 23 158013 1940 110429323
Skin reaction 28.12 13.25 80 157956 21064 110410199
Hypervolaemia 28.07 13.25 18 158018 49442 110381821
Procedural pain 28.04 13.25 8 158028 35557 110395706
Bone sequestrum 27.95 13.25 19 158017 1214 110430049
Extrapyramidal disorder 27.92 13.25 4 158032 28863 110402400
Colitis ulcerative 27.92 13.25 42 157994 77321 110353942
Vasospasm 27.90 13.25 21 158015 1575 110429688
Ischaemia 27.76 13.25 48 157988 9035 110422228
Laryngitis 27.60 13.25 13 158023 42398 110388865
Gastrointestinal mucosal necrosis 27.58 13.25 11 158025 227 110431036
Respiratory depression 27.55 13.25 6 158030 31995 110399268
Computerised tomogram abnormal 27.54 13.25 31 158005 3905 110427358
Faecal volume decreased 27.44 13.25 13 158023 412 110430851
Bronchiectasis 27.34 13.25 9 158027 36484 110394779
Ejection fraction 27.32 13.25 27 158009 2928 110428335
Gingival bleeding 27.30 13.25 76 157960 19763 110411500
Oral pain 27.28 13.25 116 157920 37328 110393935
Hallucination, auditory 27.13 13.25 3 158033 26394 110404869
Tooth erosion 27.12 13.25 13 158023 423 110430840
Vasodilatation 27.07 13.25 30 158006 3714 110427549
Coagulation factor decreased 26.87 13.25 12 158024 331 110430932
Hyperfibrinolysis 26.71 13.25 7 158029 33 110431230
Phimosis 26.66 13.25 16 158020 823 110430440
Accidental overdose 26.61 13.25 21 158015 51813 110379450
Brain cancer metastatic 26.50 13.25 12 158024 342 110430921
Small intestinal perforation 26.50 13.25 32 158004 4344 110426919
COVID-19 pneumonia 26.39 13.25 10 158026 37133 110394130
Onychomycosis 26.35 13.25 11 158025 38520 110392743
Dermatomyositis 26.32 13.25 32 158004 4374 110426889
Productive cough 26.26 13.25 80 157956 114225 110317038
Penetrating aortic ulcer 26.21 13.25 7 158029 36 110431227
Peritoneal fluid analysis abnormal 26.10 13.25 8 158028 72 110431191
Eye pain 26.10 13.25 20 158016 50079 110381184
Temperature intolerance 26.05 13.25 60 157976 13890 110417373
Hyperaesthesia 26.04 13.25 62 157974 14665 110416598
Large intestinal obstruction 26.02 13.25 30 158006 3878 110427385
Infusion site hypoaesthesia 25.89 13.25 7 158029 38 110431225
Premature delivery 25.86 13.25 6 158030 30626 110400637
Lupus-like syndrome 25.79 13.25 13 158023 40779 110390484
Sinus congestion 25.64 13.25 6 158030 30453 110400810
Eyelid ptosis 25.64 13.25 58 157978 13269 110417994
Blood glucose increased 25.53 13.25 100 157936 132396 110298867
Botryomycosis 25.44 13.25 8 158028 79 110431184
Walking aid user 25.40 13.25 3 158033 25072 110406191
Retroperitoneal lymphadenopathy 25.34 13.25 19 158017 1417 110429846
Radiation skin injury 25.31 13.25 20 158016 1612 110429651
Retroperitoneal neoplasm metastatic 25.16 13.25 7 158029 43 110431220
Anal erythema 25.09 13.25 11 158025 290 110430973
Radiation fibrosis - lung 25.00 13.25 8 158028 84 110431179
Tongue discolouration 24.97 13.25 30 158006 4051 110427212
Breast disorder 24.92 13.25 23 158013 2291 110428972
Vessel puncture site bruise 24.90 13.25 13 158023 509 110430754
Malignant pleural effusion 24.90 13.25 30 158006 4063 110427200
Blood lactate dehydrogenase abnormal 24.85 13.25 14 158022 639 110430624
Injection site bruising 24.80 13.25 22 158014 51241 110380022
Respiratory arrest 24.79 13.25 28 158008 58271 110372992
Oral pigmentation 24.76 13.25 7 158029 46 110431217
Illness 24.75 13.25 50 157986 82121 110349142
Stress 24.73 13.25 73 157963 105275 110325988
Renal vein thrombosis 24.70 13.25 17 158019 1108 110430155
Pericardial effusion 24.65 13.25 153 157883 57064 110374199
Deep vein thrombosis 24.65 13.25 307 157729 139580 110291683
Hepatic neoplasm 24.61 13.25 29 158007 3838 110427425
Hyperkalaemia 24.59 13.25 105 157931 135691 110295572
Sputum discoloured 24.55 13.25 5 158031 27940 110403323
Splenomegaly 24.54 13.25 84 157952 24414 110406849
Cerebral infarction 24.49 13.25 142 157894 51696 110379567
Hepatitis 24.48 13.25 58 157978 89996 110341267
Infection 24.48 13.25 367 157669 361833 110069430
Aplastic anaemia 24.39 13.25 3 158033 24305 110406958
Tendonitis 24.35 13.25 4 158032 26079 110405184
Cardiac haemangioma benign 24.30 13.25 5 158031 5 110431258
Human epidermal growth factor receptor negative 24.30 13.25 5 158031 5 110431258
Intestinal metastasis 24.28 13.25 13 158023 536 110430727
Poisoning 23.98 13.25 6 158030 29099 110402164
Leukonychia 23.89 13.25 8 158028 98 110431165
Hepatectomy 23.87 13.25 11 158025 327 110430936
Dysphonia 23.86 13.25 188 157848 75741 110355522
Injection site swelling 23.83 13.25 32 158004 61758 110369505
Adenocarcinoma 23.83 13.25 30 158006 4250 110427013
Electrocardiogram QT prolonged 23.81 13.25 78 157958 108882 110322381
Brachiocephalic vein thrombosis 23.74 13.25 11 158025 331 110430932
Gastrooesophageal reflux disease 23.73 13.25 155 157881 179821 110251442
Ovarian stromal hyperplasia 23.69 13.25 6 158030 24 110431239
Liver ablation 23.69 13.25 6 158030 24 110431239
Dermatitis atopic 23.66 13.25 4 158032 25537 110405726
Inappropriate schedule of product administration 23.62 13.25 182 157854 203455 110227808
Ileus paralytic 23.61 13.25 52 157984 11685 110419578
Blood alkaline phosphatase increased 23.61 13.25 178 157858 70757 110360506
Tumour invasion 23.59 13.25 13 158023 568 110430695
Loss of consciousness 23.46 13.25 174 157862 196132 110235131
Clonal haematopoiesis 23.45 13.25 9 158027 167 110431096
Device dislocation 23.44 13.25 8 158028 31696 110399567
Vocal cord paralysis 23.33 13.25 25 158011 2981 110428282
Liver function test increased 23.31 13.25 58 157978 88490 110342773
Exposed bone in jaw 23.29 13.25 28 158008 3783 110427480
Injection site haemorrhage 23.29 13.25 9 158027 33019 110398244
Cardiac output decreased 23.13 13.25 21 158015 2048 110429215
Chronic sinusitis 23.08 13.25 4 158032 25080 110406183
Hand dermatitis 23.03 13.25 14 158022 737 110430526
Brain neoplasm 22.74 13.25 36 158000 6301 110424962
Second primary malignancy 22.71 13.25 67 157969 18001 110413262
Post-traumatic neck syndrome 22.68 13.25 23 158013 2572 110428691
Glossopharyngeal nerve paralysis 22.55 13.25 7 158029 66 110431197
Laryngeal discomfort 22.49 13.25 14 158022 769 110430494
Liver abscess 22.49 13.25 40 157996 7699 110423564
Intentional product use issue 22.44 13.25 236 157800 247670 110183593
Hepatic cyst 22.32 13.25 40 157996 7743 110423520
Autoimmune hypothyroidism 22.32 13.25 12 158024 499 110430764
Hepatic mass 22.31 13.25 24 158012 2874 110428389
Paraparesis 22.29 13.25 30 158006 4536 110426727
Pancreatic fistula 22.29 13.25 8 158028 122 110431141
Lymphadenopathy mediastinal 22.28 13.25 33 158003 5451 110425812
Metastases to thorax 22.25 13.25 10 158026 280 110430983
Metastatic gastric cancer 22.21 13.25 11 158025 385 110430878
Adenocarcinoma metastatic 22.10 13.25 11 158025 389 110430874
Peripheral artery thrombosis 22.07 13.25 28 158008 3996 110427267
Emotional distress 21.99 13.25 19 158017 44828 110386435
Neuroendocrine breast tumour 21.98 13.25 6 158030 34 110431229
Anal prolapse 21.92 13.25 7 158029 73 110431190
Uterine enlargement 21.90 13.25 15 158021 970 110430293
Alopecia 21.85 13.25 378 157658 364375 110066888
Hepatopulmonary syndrome 21.83 13.25 9 158027 203 110431060
Candida infection 21.71 13.25 130 157906 47879 110383384
Hydronephrosis 21.71 13.25 72 157964 20593 110410670
Parkinsonism 21.64 13.25 3 158033 22184 110409079
Gamma-glutamyltransferase increased 21.63 13.25 156 157880 61153 110370110
Mucosal necrosis 21.62 13.25 9 158027 208 110431055
Proctalgia 21.60 13.25 54 157982 13168 110418095
Mydriasis 21.60 13.25 3 158033 22154 110409109
Transaminases 21.58 13.25 7 158029 77 110431186
Bone debridement 21.54 13.25 11 158025 411 110430852
Metastases to stomach 21.49 13.25 10 158026 304 110430959
Rectal cancer metastatic 21.48 13.25 12 158024 539 110430724
Product prescribing error 21.45 13.25 25 158011 51306 110379957
ECG signs of myocardial ischaemia 21.40 13.25 11 158025 417 110430846
Pancreatic carcinoma metastatic 21.32 13.25 28 158008 4136 110427127
Metastases to heart 21.30 13.25 11 158025 421 110430842
Hypercalcaemia of malignancy 21.25 13.25 12 158024 550 110430713
Toxic epidermal necrolysis 21.25 13.25 30 158006 56697 110374566
Haematemesis 21.20 13.25 151 157885 58957 110372306
Blood albumin decreased 21.18 13.25 87 157949 27565 110403698
Bone marrow infiltration 21.17 13.25 14 158022 854 110430409
Eosinophilic pneumonia chronic 21.15 13.25 12 158024 555 110430708
Circulatory collapse 21.12 13.25 119 157917 42874 110388389
Ear malformation 21.11 13.25 5 158031 14 110431249
Portal vein phlebitis 21.11 13.25 5 158031 14 110431249
Ear pain 21.11 13.25 27 158009 53199 110378064
Viral infection 21.03 13.25 27 158009 53112 110378151
Cognitive disorder 21.01 13.25 60 157976 87451 110343812
Peripheral sensorimotor neuropathy 20.94 13.25 27 158009 3916 110427347
Dermatitis 20.87 13.25 87 157949 27750 110403513
Haematoma 20.86 13.25 32 158004 58444 110372819
Enterocolitis haemorrhagic 20.82 13.25 22 158014 2582 110428681
Renal hydrocele 20.77 13.25 6 158030 43 110431220
Psychological trauma 20.73 13.25 18 158018 1655 110429608
Periodontitis 20.68 13.25 31 158005 5177 110426086
Coagulopathy 20.60 13.25 114 157922 40797 110390466
Dental care 20.54 13.25 15 158021 1074 110430189
Vascular device infection 20.54 13.25 61 157975 16451 110414812
Hormone receptor positive HER2 negative breast cancer 20.54 13.25 9 158027 237 110431026
Hyperhidrosis 20.52 13.25 170 157866 187128 110244135
Restless legs syndrome 20.44 13.25 5 158031 24621 110406642
Vasculitis 20.43 13.25 13 158023 35860 110395403
Febrile neutropenia 20.41 13.25 595 157441 316172 110115091
Vein disorder 20.30 13.25 34 158002 6236 110425027
Administration site extravasation 20.22 13.25 18 158018 1711 110429552
Parathyroid tumour malignant 20.20 13.25 8 158028 162 110431101
Hypoaesthesia 20.18 13.25 590 157446 313633 110117630
Nephrotic syndrome 20.04 13.25 54 157982 13777 110417486
Acute respiratory failure 20.04 13.25 49 157987 75211 110356052
Herpangina 19.98 13.25 6 158030 50 110431213
Tumour exudation 19.98 13.25 4 158032 3 110431260
Calcium ionised increased 19.88 13.25 10 158026 362 110430901
Superior vena cava syndrome 19.87 13.25 16 158020 1325 110429938
Gastrointestinal oedema 19.78 13.25 24 158012 3274 110427989
Tenderness 19.77 13.25 89 157947 29348 110401915
Device malfunction 19.69 13.25 6 158030 25552 110405711
Gastroenteritis radiation 19.63 13.25 13 158023 795 110430468
Hepatic infarction 19.62 13.25 14 158022 967 110430296
Diabetes mellitus inadequate control 19.57 13.25 9 158027 29766 110401497
Perforation 19.51 13.25 18 158018 1792 110429471
Fistula 19.49 13.25 57 157979 15242 110416021
Ileal ulcer 19.45 13.25 18 158018 1799 110429464
Frequent bowel movements 19.39 13.25 46 157990 71344 110359919
Blood lactate dehydrogenase increased 19.38 13.25 119 157917 44215 110387048
Joint stiffness 19.34 13.25 42 157994 67201 110364062
Perineal ulceration 19.31 13.25 7 158029 110 110431153
Oropharyngeal pain 19.13 13.25 114 157922 135162 110296101
Metastases to spleen 19.12 13.25 13 158023 831 110430432
Gastrointestinal necrosis 18.88 13.25 34 158002 6606 110424657
Penile ulceration 18.78 13.25 12 158024 690 110430573
Acute generalised exanthematous pustulosis 18.78 13.25 4 158032 21660 110409603
Macular degeneration 18.77 13.25 4 158032 21655 110409608
Rectal cancer recurrent 18.75 13.25 6 158030 63 110431200
Full blood count abnormal 18.75 13.25 32 158004 56020 110375243
Feeling cold 18.67 13.25 97 157939 33890 110397373
Peripheral motor neuropathy 18.67 13.25 26 158010 4060 110427203
Breast neoplasm 18.67 13.25 14 158022 1044 110430219
Venous thrombosis 18.63 13.25 39 157997 8466 110422797
Colorectostomy 18.55 13.25 4 158032 6 110431257
Hyperchlorhydria 18.55 13.25 19 158017 2150 110429113
Nail toxicity 18.51 13.25 10 158026 420 110430843
Pemphigoid 18.45 13.25 3 158033 19704 110411559
Blood pressure increased 18.43 13.25 259 157777 258114 110173149
Mechanical ileus 18.42 13.25 15 158021 1262 110430001
Gastroenteritis 18.15 13.25 106 157930 38694 110392569
Limbal stem cell deficiency 18.10 13.25 6 158030 71 110431192
Eye infection gonococcal 18.07 13.25 5 158031 30 110431233
Left ventricular failure 18.07 13.25 46 157990 11343 110419920
Malignant peritoneal neoplasm 18.02 13.25 12 158024 741 110430522
Gamma-glutamyltransferase abnormal 18.01 13.25 13 158023 914 110430349
Respiratory tract infection 18.01 13.25 48 157988 71569 110359694
Intestinal dilatation 18.00 13.25 24 158012 3596 110427667
Radiculopathy 17.97 13.25 3 158033 19333 110411930
Toothache 17.92 13.25 74 157962 23501 110407762
Colitis ischaemic 17.90 13.25 61 157975 17689 110413574
Sinus bradycardia 17.75 13.25 10 158026 29473 110401790
Brain natriuretic peptide decreased 17.73 13.25 6 158030 76 110431187
Paranoia 17.70 13.25 5 158031 22369 110408894
Delusion 17.55 13.25 6 158030 23749 110407514
Dyskinesia 17.55 13.25 29 158007 51417 110379846
Eczema impetiginous 17.54 13.25 5 158031 34 110431229
Hypocalcaemia 17.43 13.25 156 157880 65210 110366053
Cardiac ventricular thrombosis 17.43 13.25 22 158014 3125 110428138
Myoclonus 17.41 13.25 13 158023 32985 110398278
Coma 17.38 13.25 98 157938 117771 110313492
Hypertension 17.37 13.25 576 157460 509508 109921755
Miosis 17.23 13.25 5 158031 21978 110409285
Underdose 17.22 13.25 41 157995 63513 110367750
Blood pressure systolic abnormal 17.15 13.25 7 158029 24843 110406420
Sinus disorder 17.13 13.25 13 158023 32715 110398548
Pulmonary tumour thrombotic microangiopathy 17.10 13.25 7 158029 155 110431108
Gastric varices haemorrhage 17.08 13.25 10 158026 491 110430772
Central nervous system lesion 17.06 13.25 55 157981 15498 110415765
Hyperglycaemia 16.86 13.25 191 157845 84899 110346364
Influenza like illness 16.86 13.25 67 157969 88345 110342918
Nail avulsion 16.85 13.25 7 158029 161 110431102
Portal hypertensive gastropathy 16.84 13.25 17 158019 1891 110429372
Neurological decompensation 16.78 13.25 33 158003 6850 110424413
Catheter site inflammation 16.71 13.25 14 158022 1226 110430037
Metastases to muscle 16.70 13.25 9 158027 376 110430887
Myocardial ischaemia 16.68 13.25 79 157957 26605 110404658
Paresis 16.67 13.25 27 158009 4817 110426446
Gastrointestinal stoma complication 16.66 13.25 22 158014 3267 110427996
Urethral ulcer 16.66 13.25 3 158033 0 110431263
Hyperglycaemic hyperosmolar nonketotic syndrome 16.61 13.25 21 158015 2988 110428275
Multiple sclerosis 16.53 13.25 8 158028 25690 110405573
Cryptitis 16.53 13.25 9 158027 384 110430879
Adverse reaction 16.48 13.25 11 158025 29583 110401680
Tinnitus 16.45 13.25 39 157997 60501 110370762
Mood swings 16.45 13.25 6 158030 22806 110408457
Radiation myelopathy 16.44 13.25 4 158032 13 110431250
Pelvic venous thrombosis 16.39 13.25 20 158016 2744 110428519
Colorectal cancer recurrent 16.28 13.25 6 158030 99 110431164
Capillary nail refill test abnormal 16.23 13.25 6 158030 100 110431163
Formication 16.16 13.25 29 158007 5619 110425644
Gallbladder disorder 16.09 13.25 5 158031 21024 110410239
Limb injury 16.09 13.25 18 158018 37618 110393645
Cytomegalovirus enterocolitis 16.02 13.25 18 158018 2263 110429000
Cytomegalovirus viraemia 15.98 13.25 3 158033 17761 110413502
Mastitis 15.97 13.25 19 158017 2539 110428724
Back disorder 15.96 13.25 5 158031 20917 110410346
Cataract 15.95 13.25 59 157977 79426 110351837
Neuromuscular toxicity 15.95 13.25 9 158027 412 110430851
Head injury 15.87 13.25 23 158013 42994 110388269
Impaired work ability 15.85 13.25 9 158027 26410 110404853
Brain operation 15.85 13.25 12 158024 908 110430355
Tumour marker abnormal 15.82 13.25 8 158028 293 110430970
Neoplasm 15.78 13.25 43 157993 11044 110420219
Acral peeling skin syndrome 15.75 13.25 5 158031 51 110431212
Hepatitis cholestatic 15.73 13.25 3 158033 17563 110413700
Cholecystitis 15.73 13.25 76 157960 25806 110405457
Chemical peritonitis 15.72 13.25 8 158028 297 110430966
Gastric dilatation 15.61 13.25 17 158019 2064 110429199
Schistosomiasis 15.58 13.25 5 158031 53 110431210
Ill-defined disorder 15.58 13.25 146 157890 156707 110274556
Abdominal sepsis 15.55 13.25 18 158018 2337 110428926
Hypersplenism 15.48 13.25 11 158025 755 110430508
Prostatic calcification 15.45 13.25 6 158030 115 110431148
Jaundice cholestatic 15.43 13.25 51 157985 14557 110416706
Appendicitis noninfective 15.42 13.25 4 158032 18 110431245
Pelvic pain 15.39 13.25 54 157982 15888 110415375
Hypoxia 15.37 13.25 115 157921 129400 110301863
Lung neoplasm 15.37 13.25 35 158001 8041 110423222
Hyperproteinaemia 15.35 13.25 8 158028 312 110430951
Cardiac murmur 15.35 13.25 8 158028 24620 110406643
Rash pruritic 15.30 13.25 80 157956 97989 110333274
Burn oesophageal 15.28 13.25 9 158027 447 110430816
Dystonia 15.19 13.25 9 158027 25796 110405467
Hyperbaric oxygen therapy 15.18 13.25 5 158031 58 110431205
Hepatic cancer metastatic 15.15 13.25 12 158024 971 110430292
Malnutrition 15.09 13.25 78 157958 27201 110404062
Urinary tract infection 15.07 13.25 353 157683 325929 110105334
Chemotherapy cardiotoxicity attenuation 15.07 13.25 4 158032 20 110431243
Urinary tract toxicity 15.07 13.25 4 158032 20 110431243
Bronchospasm 15.05 13.25 84 157952 30155 110401108
Motion sickness 15.04 13.25 13 158023 1188 110430075
Breast necrosis 15.04 13.25 6 158030 124 110431139
Venous thrombosis limb 15.02 13.25 27 158009 5238 110426025
Gastrointestinal wall thickening 15.01 13.25 22 158014 3601 110427662
Vertebral column mass 14.99 13.25 8 158028 328 110430935
Chronic myeloid leukaemia 14.96 13.25 24 158012 4249 110427014
Erectile dysfunction 14.95 13.25 4 158032 18552 110412711
Oesophageal varices haemorrhage 14.94 13.25 26 158010 4919 110426344
Metastases to bladder 14.83 13.25 8 158028 335 110430928
Metastases to bone marrow 14.82 13.25 12 158024 1002 110430261
Peripheral coldness 14.73 13.25 59 157977 18481 110412782
Anastomotic haemorrhage 14.68 13.25 8 158028 342 110430921
Radiation injury 14.67 13.25 12 158024 1016 110430247
Lung neoplasm malignant 14.67 13.25 16 158020 33826 110397437
Tumour excision 14.67 13.25 10 158026 642 110430621
Sequestrectomy 14.62 13.25 11 158025 825 110430438
Impaired gastric emptying 14.61 13.25 47 157989 13228 110418035
Haemolytic anaemia 14.61 13.25 64 157972 20856 110410407
Blood magnesium decreased 14.60 13.25 62 157974 19934 110411329
Malaise 14.60 13.25 798 157238 671021 109760242
Femoral artery embolism 14.59 13.25 5 158031 66 110431197
Abdominal fat apron 14.58 13.25 3 158033 3 110431260
Increased liver stiffness 14.58 13.25 3 158033 3 110431260
Pituitary tumour 14.56 13.25 13 158023 1240 110430023
Panic attack 14.51 13.25 12 158024 28928 110402335
Herpes simplex encephalitis 14.51 13.25 11 158025 834 110430429
Ureteric obstruction 14.51 13.25 20 158016 3094 110428169
Drug tolerance 14.50 13.25 3 158033 16582 110414681
Gene mutation 14.46 13.25 21 158015 3408 110427855
Mesenteric vein thrombosis 14.45 13.25 16 158020 1979 110429284
Unresponsive to stimuli 14.40 13.25 45 157991 63745 110367518
Fungal infection 14.39 13.25 32 158004 50774 110380489
Liver scan abnormal 14.39 13.25 5 158031 69 110431194
Pleural disorder 14.36 13.25 12 158024 1047 110430216
Adenocarcinoma of colon 14.35 13.25 29 158007 6139 110425124
Blood potassium decreased 14.35 13.25 129 157907 53985 110377278
Varicose vein 14.25 13.25 31 158005 6909 110424354
Drug eruption 14.24 13.25 35 158001 53624 110377639
Dacryostenosis acquired 14.23 13.25 10 158026 674 110430589
Concomitant disease aggravated 14.23 13.25 3 158033 16361 110414902
Rhinitis allergic 14.19 13.25 4 158032 17918 110413345
Idiosyncratic drug reaction 14.14 13.25 14 158022 1522 110429741
Metastases to thyroid 14.13 13.25 5 158031 73 110431190
Radioisotope scan 14.12 13.25 3 158033 4 110431259
Osteolysis 14.10 13.25 27 158009 5496 110425767
Biliary fistula 14.09 13.25 6 158030 147 110431116
Pain in jaw 14.09 13.25 123 157913 51054 110380209
Nephrolithiasis 14.05 13.25 48 157988 66164 110365099
Gastroenteropancreatic neuroendocrine tumour disease 14.01 13.25 5 158031 75 110431188
Right ventricular failure 13.98 13.25 10 158026 25944 110405319
Tubulointerstitial nephritis 13.94 13.25 36 158000 54248 110377015
Subdural haematoma 13.93 13.25 19 158017 36435 110394828
Abdominal wall oedema 13.93 13.25 4 158032 28 110431235
Skin mass 13.90 13.25 38 157998 9778 110421485
Periportal sinus dilatation 13.87 13.25 6 158030 153 110431110
Bleeding varicose vein 13.86 13.25 10 158026 703 110430560
Cerebellar ataxia 13.85 13.25 16 158020 2072 110429191
Actinomycosis 13.81 13.25 13 158023 1327 110429936
Normal newborn 13.81 13.25 7 158029 21889 110409374
Heart rate increased 13.81 13.25 135 157901 143699 110287564
Pharyngeal ulceration 13.81 13.25 13 158023 1328 110429935
Retinal detachment 13.80 13.25 41 157995 11059 110420204
Skin sensitisation 13.79 13.25 12 158024 1107 110430156
Thrombotic thrombocytopenic purpura 13.74 13.25 31 158005 7080 110424183
Pulmonary toxicity 13.73 13.25 56 157980 17690 110413573
Head discomfort 13.69 13.25 5 158031 18995 110412268
False negative investigation result 13.66 13.25 8 158028 393 110430870
Eye pruritus 13.65 13.25 16 158020 32759 110398504
Irritability 13.64 13.25 30 158006 47779 110383484
Kidney infection 13.61 13.25 10 158026 25589 110405674
Upper-airway cough syndrome 13.60 13.25 3 158033 15854 110415409
Secretion discharge 13.49 13.25 6 158030 20238 110411025
Metastases to pancreas 13.46 13.25 10 158026 735 110430528
Diarrhoea haemorrhagic 13.43 13.25 51 157985 15588 110415675
Pleural neoplasm 13.43 13.25 8 158028 406 110430857
Orthostatic hypotension 13.41 13.25 49 157987 66200 110365063
Post transplant lymphoproliferative disorder 13.29 13.25 3 158033 15610 110415653
Gastroenteritis viral 13.27 13.25 15 158021 31211 110400052

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
ATC L01BC06 ANTINEOPLASTIC AND IMMUNOMODULATING AGENTS
ANTINEOPLASTIC AGENTS
ANTIMETABOLITES
Pyrimidine analogues
FDA MoA N0000000233 Nucleic Acid Synthesis Inhibitors
MeSH PA D000963 Antimetabolites
MeSH PA D000964 Antimetabolites, Antineoplastic
MeSH PA D000970 Antineoplastic Agents
FDA EPC N0000175595 Nucleoside Metabolic Inhibitor
CHEBI has role CHEBI:35221 antimetabolite
CHEBI has role CHEBI:35610 antineoplastic agent
CHEBI has role CHEBI:50266 prodrug

Related Drugs by ATC class:

L01BC Pyrimidine analogues 9 drugs
azacitidinecarmofurcytarabinedecitabinefloxuridinefluorouracilgemcitabinetegafurtrifluridine

Drug Use | Suggest Off label Use Form| |View source of the data|

DiseaseRelationSNOMED_IDDOID
Metastasis from malignant tumor of colon indication 314998002
Malignant tumor of stomach indication 363349007 DOID:10534
Metastatic Breast Carcinoma indication
Lymph Node Positive Colorectal Carcinoma indication
Malignant tumor of ovary off-label use 363443007 DOID:2394
Adenocarcinoma of pancreas off-label use 700423003 DOID:4074
Pancreatic Neuroendocrine Tumor off-label use 717919005
Necrotizing enterocolitis in fetus OR newborn contraindication 2707005
Hyperbilirubinemia contraindication 14783006 DOID:2741
Infectious disease contraindication 40733004
Conduction disorder of the heart contraindication 44808001
Acute nephropathy contraindication 58574008
Stomatitis contraindication 61170000 DOID:9637
Dihydrouracil dehydrogenase (NADP^+^) deficiency contraindication 77365006 DOID:14218
Impaired renal function disorder contraindication 197663003
Disease of liver contraindication 235856003 DOID:409
Anemia contraindication 271737000 DOID:2355
Pregnancy, function contraindication 289908002
Thrombocytopenic disorder contraindication 302215000 DOID:1588
Neutropenic disorder contraindication 303011007 DOID:1227
Severe diarrhea contraindication 409587002
Breastfeeding (mother) contraindication 413712001
Disorder of coronary artery contraindication 414024009
Palmar-Plantar Erythrodysesthesia contraindication




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 12.3 acidic
pKa2 12.91 acidic
pKa3 13.46 acidic
pKa4 0.75 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])		Mechanism
action		Bioact sourceMoA source
Thymidylate synthase Enzyme INHIBITOR WOMBAT-PK CHEMBL

External reference:

IDSource
4021099 VUID
N0000148555 NUI
D01223 KEGG_DRUG
194000 RXNORM
C0671970 UMLSCUI
CHEBI:31348 CHEBI
CHEMBL1773 ChEMBL_ID
DB01101 DRUGBANK_ID
D000069287 MESH_DESCRIPTOR_UI
60953 PUBCHEM_CID
6799 IUPHAR_LIGAND_ID
7317 INN_ID
6804DJ8Z9U UNII
11693 MMSL
210675 MMSL
4344 MMSL
d04311 MMSL
108761006 SNOMEDCT_US
386906001 SNOMEDCT_US
4021099 VANDF
007533 NDDF
6804DJ8Z9U INXIGHT DRUGS

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
Capecitabine HUMAN PRESCRIPTION DRUG LABEL 1 0093-7473 TABLET, FILM COATED 150 mg ORAL ANDA 29 sections
Capecitabine HUMAN PRESCRIPTION DRUG LABEL 1 0093-7474 TABLET, FILM COATED 500 mg ORAL ANDA 29 sections
CAPECITABINE HUMAN PRESCRIPTION DRUG LABEL 1 16729-072 TABLET, FILM COATED 150 mg ORAL ANDA 28 sections
CAPECITABINE HUMAN PRESCRIPTION DRUG LABEL 1 16729-073 TABLET, FILM COATED 500 mg ORAL ANDA 28 sections
capecitabine HUMAN PRESCRIPTION DRUG LABEL 1 31722-774 TABLET, FILM COATED 150 mg ORAL ANDA 30 sections
capecitabine HUMAN PRESCRIPTION DRUG LABEL 1 31722-775 TABLET, FILM COATED 500 mg ORAL ANDA 30 sections
Capecitabine HUMAN PRESCRIPTION DRUG LABEL 1 51407-639 TABLET, FILM COATED 150 mg ORAL ANDA 29 sections
Capecitabine HUMAN PRESCRIPTION DRUG LABEL 1 51407-640 TABLET, FILM COATED 500 mg ORAL ANDA 29 sections
Xeloda HUMAN PRESCRIPTION DRUG LABEL 1 53808-0411 TABLET, FILM COATED 500 mg ORAL NDA 24 sections
Xeloda HUMAN PRESCRIPTION DRUG LABEL 1 54868-4143 TABLET, FILM COATED 150 mg ORAL NDA 30 sections
Xeloda HUMAN PRESCRIPTION DRUG LABEL 1 54868-5260 TABLET, FILM COATED 500 mg ORAL NDA 30 sections
capecitabine HUMAN PRESCRIPTION DRUG LABEL 1 55111-496 TABLET 150 mg ORAL ANDA 27 sections
capecitabine HUMAN PRESCRIPTION DRUG LABEL 1 55111-497 TABLET 500 mg ORAL ANDA 27 sections
Capecitabine Human Prescription Drug Label 1 59651-204 TABLET 150 mg ORAL ANDA 30 sections
Capecitabine Human Prescription Drug Label 1 59651-205 TABLET 500 mg ORAL ANDA 30 sections
Capecitabine HUMAN PRESCRIPTION DRUG LABEL 1 59923-721 TABLET, FILM COATED 150 mg ORAL ANDA 28 sections
Capecitabine HUMAN PRESCRIPTION DRUG LABEL 1 59923-722 TABLET, FILM COATED 500 mg ORAL ANDA 28 sections
Capecitabine HUMAN PRESCRIPTION DRUG LABEL 1 60687-149 TABLET, FILM COATED 500 mg ORAL ANDA 29 sections
Xeloda HUMAN PRESCRIPTION DRUG LABEL 1 61269-470 TABLET, FILM COATED 150 mg ORAL NDA 36 sections
Xeloda HUMAN PRESCRIPTION DRUG LABEL 1 61269-470 TABLET, FILM COATED 150 mg ORAL NDA 36 sections
Xeloda HUMAN PRESCRIPTION DRUG LABEL 1 61269-475 TABLET, FILM COATED 500 mg ORAL NDA 36 sections
Xeloda HUMAN PRESCRIPTION DRUG LABEL 1 61269-475 TABLET, FILM COATED 500 mg ORAL NDA 36 sections
Capecitabine HUMAN PRESCRIPTION DRUG LABEL 1 62756-238 TABLET, FILM COATED 150 mg ORAL ANDA 36 sections
Capecitabine HUMAN PRESCRIPTION DRUG LABEL 1 62756-239 TABLET, FILM COATED 500 mg ORAL ANDA 36 sections
Capecitabine Human Prescription Drug Label 1 67877-458 TABLET, FILM COATED 150 mg ORAL ANDA 29 sections
Capecitabine Human Prescription Drug Label 1 67877-459 TABLET, FILM COATED 500 mg ORAL ANDA 29 sections
CAPECITABINE HUMAN PRESCRIPTION DRUG LABEL 1 68001-487 TABLET, FILM COATED 150 mg ORAL ANDA 28 sections
CAPECITABINE HUMAN PRESCRIPTION DRUG LABEL 1 68001-488 TABLET, FILM COATED 500 mg ORAL ANDA 28 sections
Capecitabine HUMAN PRESCRIPTION DRUG LABEL 1 68001-643 TABLET, FILM COATED 150 mg ORAL ANDA 29 sections
Capecitabine HUMAN PRESCRIPTION DRUG LABEL 1 68001-644 TABLET, FILM COATED 500 mg ORAL ANDA 29 sections