Stem definition | Drug id | CAS RN |
---|---|---|
nucleosides antiviral or antineoplastic agents, cytarabine or azacitidine derivatives | 480 | 154361-50-9 |
None
Property | Value | Reference |
---|---|---|
BDDCS (Biopharmaceutical Drug Disposition Classification System) | 1 | Benet LZ, Broccatelli F, Oprea TI |
S (Water solubility) | 26 mg/mL | Benet LZ, Broccatelli F, Oprea TI |
EoM (Fraction excreted unchanged in urine) | 3 % | Benet LZ, Broccatelli F, Oprea TI |
MRTD (Maximum Recommended Therapeutic Daily Dose) | 171.93 ยตM/kg/day | Contrera JF, Matthews EJ, Kruhlak NL, Benz RD |
BA (Bioavailability) | 99 % | Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H |
Date | Agency | Company | Orphan |
---|---|---|---|
April 30, 1998 | FDA | HOFFMANN LA ROCHE | |
April 16, 2003 | PMDA | CHUGAI PHARMACEUTICAL CO., LTD. |
MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
---|---|---|---|---|---|---|
Palmar-plantar erythrodysaesthesia syndrome | 7362.06 | 12.75 | 2375 | 99604 | 17723 | 50485422 |
Disease progression | 3100.19 | 12.75 | 2091 | 99888 | 93775 | 50409370 |
Diarrhoea | 2265.44 | 12.75 | 4140 | 97839 | 584336 | 49918809 |
Malignant neoplasm progression | 2057.15 | 12.75 | 1426 | 100553 | 66698 | 50436447 |
Metastases to liver | 1365.90 | 12.75 | 710 | 101269 | 19394 | 50483751 |
Metastases to bone | 1163.86 | 12.75 | 615 | 101364 | 17380 | 50485765 |
Death | 1072.35 | 12.75 | 2152 | 99827 | 323227 | 50179918 |
Mucosal inflammation | 1023.45 | 12.75 | 759 | 101220 | 39383 | 50463762 |
Metastases to central nervous system | 702.28 | 12.75 | 376 | 101603 | 10906 | 50492239 |
Metastases to lung | 646.16 | 12.75 | 353 | 101626 | 10667 | 50492478 |
Breast cancer metastatic | 536.75 | 12.75 | 306 | 101673 | 10058 | 50493087 |
Vomiting | 471.96 | 12.75 | 2004 | 99975 | 458754 | 50044391 |
Neuropathy peripheral | 455.52 | 12.75 | 749 | 101230 | 96008 | 50407137 |
Neutropenia | 446.45 | 12.75 | 946 | 101033 | 147019 | 50356126 |
Drug ineffective | 435.08 | 12.75 | 614 | 101365 | 818719 | 49684426 |
Neoplasm progression | 426.55 | 12.75 | 400 | 101579 | 28757 | 50474388 |
Metastases to lymph nodes | 400.70 | 12.75 | 221 | 101758 | 6803 | 50496342 |
Dehydration | 394.84 | 12.75 | 917 | 101062 | 151532 | 50351613 |
Rheumatoid arthritis | 391.25 | 12.75 | 3 | 101976 | 202547 | 50300598 |
Stomatitis | 382.67 | 12.75 | 712 | 101267 | 100632 | 50402513 |
Skin exfoliation | 355.71 | 12.75 | 387 | 101592 | 33225 | 50469920 |
Nausea | 309.38 | 12.75 | 2448 | 99531 | 702950 | 49800195 |
Bone marrow failure | 308.00 | 12.75 | 327 | 101652 | 27297 | 50475848 |
Joint swelling | 296.31 | 12.75 | 66 | 101913 | 245220 | 50257925 |
Gastrointestinal toxicity | 294.15 | 12.75 | 157 | 101822 | 4520 | 50498625 |
Skin fissures | 293.09 | 12.75 | 195 | 101784 | 8473 | 50494672 |
Neurotoxicity | 289.28 | 12.75 | 239 | 101740 | 14501 | 50488644 |
Skin toxicity | 267.82 | 12.75 | 139 | 101840 | 3774 | 50499371 |
Metastases to skin | 264.44 | 12.75 | 101 | 101878 | 1282 | 50501863 |
Contraindicated product administered | 263.60 | 12.75 | 8 | 101971 | 148950 | 50354195 |
Paronychia | 258.67 | 12.75 | 143 | 101836 | 4421 | 50498724 |
Maternal exposure during pregnancy | 249.66 | 12.75 | 19 | 101960 | 159759 | 50343386 |
Systemic lupus erythematosus | 247.21 | 12.75 | 8 | 101971 | 140614 | 50362531 |
Condition aggravated | 244.81 | 12.75 | 148 | 101831 | 296910 | 50206235 |
Decreased appetite | 242.94 | 12.75 | 922 | 101057 | 200001 | 50303144 |
Completed suicide | 241.25 | 12.75 | 5 | 101974 | 131884 | 50371261 |
Arthralgia | 229.40 | 12.75 | 331 | 101648 | 438371 | 50064774 |
Dry skin | 224.43 | 12.75 | 350 | 101629 | 42841 | 50460304 |
Arthropathy | 222.57 | 12.75 | 28 | 101951 | 157878 | 50345267 |
Arteriospasm coronary | 221.86 | 12.75 | 117 | 101862 | 3285 | 50499860 |
Drug hypersensitivity | 221.24 | 12.75 | 115 | 101864 | 250895 | 50252250 |
Osteonecrosis of jaw | 220.60 | 12.75 | 299 | 101680 | 32227 | 50470918 |
Myelosuppression | 220.15 | 12.75 | 197 | 101782 | 13320 | 50489825 |
Thrombocytopenia | 218.89 | 12.75 | 659 | 101320 | 127014 | 50376131 |
Metastasis | 207.42 | 12.75 | 122 | 101857 | 4253 | 50498892 |
Haematotoxicity | 202.55 | 12.75 | 150 | 101829 | 7745 | 50495400 |
Breast cancer | 198.84 | 12.75 | 330 | 101649 | 42560 | 50460585 |
Enteritis | 191.00 | 12.75 | 138 | 101841 | 6857 | 50496288 |
Sinusitis | 182.91 | 12.75 | 58 | 101921 | 170500 | 50332645 |
Exposure during pregnancy | 181.84 | 12.75 | 17 | 101962 | 120998 | 50382147 |
Skin discolouration | 179.36 | 12.75 | 272 | 101707 | 32485 | 50470660 |
Tumour marker increased | 179.21 | 12.75 | 106 | 101873 | 3734 | 50499411 |
Therapeutic product effect decreased | 178.08 | 12.75 | 30 | 101949 | 136020 | 50367125 |
Cardiotoxicity | 174.67 | 12.75 | 131 | 101848 | 6896 | 50496249 |
Laryngospasm | 174.02 | 12.75 | 92 | 101887 | 2596 | 50500549 |
Fall | 167.77 | 12.75 | 260 | 101719 | 334672 | 50168473 |
Glossodynia | 166.50 | 12.75 | 19 | 101960 | 115550 | 50387595 |
Dihydropyrimidine dehydrogenase deficiency | 163.84 | 12.75 | 37 | 101942 | 44 | 50503101 |
Ascites | 150.48 | 12.75 | 264 | 101715 | 35597 | 50467548 |
Metastases to peritoneum | 144.91 | 12.75 | 83 | 101896 | 2750 | 50500395 |
Weight increased | 143.20 | 12.75 | 118 | 101861 | 201773 | 50301372 |
Asthenia | 142.37 | 12.75 | 1114 | 100865 | 317928 | 50185217 |
Pseudocirrhosis | 142.34 | 12.75 | 52 | 101927 | 578 | 50502567 |
Pleural effusion | 140.95 | 12.75 | 422 | 101557 | 81032 | 50422113 |
Product use issue | 139.92 | 12.75 | 63 | 101916 | 149412 | 50353733 |
Metastases to pleura | 139.70 | 12.75 | 63 | 101916 | 1243 | 50501902 |
Treatment failure | 138.56 | 12.75 | 52 | 101927 | 137585 | 50365560 |
Therapy cessation | 138.18 | 12.75 | 213 | 101766 | 25798 | 50477347 |
Osteonecrosis | 137.73 | 12.75 | 197 | 101782 | 22320 | 50480825 |
Nail disorder | 137.73 | 12.75 | 131 | 101848 | 9577 | 50493568 |
PIK3CA-activated mutation | 133.10 | 12.75 | 53 | 101926 | 757 | 50502388 |
Musculoskeletal stiffness | 130.24 | 12.75 | 48 | 101931 | 128433 | 50374712 |
Metastases to spine | 129.12 | 12.75 | 77 | 101902 | 2754 | 50500391 |
Metastatic neoplasm | 123.40 | 12.75 | 83 | 101896 | 3671 | 50499474 |
Psoriasis | 120.94 | 12.75 | 4 | 101975 | 68996 | 50434149 |
Hepatic function abnormal | 117.42 | 12.75 | 225 | 101754 | 32456 | 50470689 |
Wound | 115.11 | 12.75 | 35 | 101944 | 105759 | 50397386 |
Lymphangiosis carcinomatosa | 113.22 | 12.75 | 53 | 101926 | 1143 | 50502002 |
Swelling | 112.30 | 12.75 | 144 | 101835 | 200728 | 50302417 |
Headache | 111.60 | 12.75 | 584 | 101395 | 505951 | 49997194 |
Hepatic lesion | 111.54 | 12.75 | 80 | 101899 | 3928 | 50499217 |
Drug interaction | 108.62 | 12.75 | 146 | 101833 | 199475 | 50303670 |
Onycholysis | 107.94 | 12.75 | 53 | 101926 | 1275 | 50501870 |
Breast cancer recurrent | 105.96 | 12.75 | 76 | 101903 | 3732 | 50499413 |
Hospice care | 105.81 | 12.75 | 90 | 101889 | 5682 | 50497463 |
Pain | 104.56 | 12.75 | 711 | 101268 | 578192 | 49924953 |
Ejection fraction decreased | 103.09 | 12.75 | 155 | 101824 | 18365 | 50484780 |
Injection site pain | 100.47 | 12.75 | 49 | 101930 | 110975 | 50392170 |
Pericarditis | 99.36 | 12.75 | 19 | 101960 | 78670 | 50424475 |
Blood bilirubin increased | 98.83 | 12.75 | 207 | 101772 | 31831 | 50471314 |
Carbohydrate antigen 15-3 increased | 97.49 | 12.75 | 47 | 101932 | 1085 | 50502060 |
Abdominal discomfort | 96.79 | 12.75 | 201 | 101778 | 231440 | 50271705 |
Pruritus | 96.48 | 12.75 | 274 | 101705 | 283294 | 50219851 |
Arthritis | 95.59 | 12.75 | 28 | 101951 | 86693 | 50416452 |
Infusion related reaction | 94.28 | 12.75 | 122 | 101857 | 169435 | 50333710 |
Overdose | 90.26 | 12.75 | 44 | 101935 | 99683 | 50403462 |
Pneumonia | 89.67 | 12.75 | 425 | 101554 | 377976 | 50125169 |
Discomfort | 89.08 | 12.75 | 54 | 101925 | 108326 | 50394819 |
Carcinoembryonic antigen increased | 88.54 | 12.75 | 48 | 101931 | 1426 | 50501719 |
Jaundice | 87.71 | 12.75 | 176 | 101803 | 26253 | 50476892 |
Bone lesion | 87.46 | 12.75 | 77 | 101902 | 5093 | 50498052 |
Depression | 86.95 | 12.75 | 124 | 101855 | 165299 | 50337846 |
Bronchitis | 86.87 | 12.75 | 51 | 101928 | 104108 | 50399037 |
Paraesthesia | 86.62 | 12.75 | 474 | 101505 | 119769 | 50383376 |
Influenza | 86.51 | 12.75 | 36 | 101943 | 89502 | 50413643 |
Hyperbilirubinaemia | 85.55 | 12.75 | 101 | 101878 | 9469 | 50493676 |
Intestinal obstruction | 84.35 | 12.75 | 173 | 101806 | 26210 | 50476935 |
Irritable bowel syndrome | 83.55 | 12.75 | 5 | 101974 | 51436 | 50451709 |
Polyneuropathy | 82.95 | 12.75 | 112 | 101867 | 12019 | 50491126 |
Lower respiratory tract infection | 81.70 | 12.75 | 45 | 101934 | 95156 | 50407989 |
Intentional overdose | 81.26 | 12.75 | 14 | 101965 | 62490 | 50440655 |
Bradycardia | 80.40 | 12.75 | 16 | 101963 | 64410 | 50438735 |
Therapeutic product effect incomplete | 80.38 | 12.75 | 42 | 101937 | 91473 | 50411672 |
Febrile neutropenia | 75.78 | 12.75 | 393 | 101586 | 97274 | 50405871 |
Urticaria | 74.32 | 12.75 | 91 | 101888 | 129470 | 50373675 |
Osteoarthritis | 74.07 | 12.75 | 23 | 101956 | 68583 | 50434562 |
Abdominal lymphadenopathy | 73.32 | 12.75 | 33 | 101946 | 648 | 50502497 |
Leukopenia | 71.01 | 12.75 | 297 | 101682 | 67231 | 50435914 |
Nasopharyngitis | 70.39 | 12.75 | 180 | 101799 | 192747 | 50310398 |
Asthma | 70.00 | 12.75 | 47 | 101932 | 89290 | 50413855 |
Non-cirrhotic portal hypertension | 69.66 | 12.75 | 22 | 101957 | 150 | 50502995 |
Duodenal ulcer perforation | 69.58 | 12.75 | 6 | 101973 | 45605 | 50457540 |
Infusion site coldness | 68.90 | 12.75 | 23 | 101956 | 191 | 50502954 |
Colitis | 68.86 | 12.75 | 202 | 101777 | 38327 | 50464818 |
Dysaesthesia pharynx | 68.64 | 12.75 | 21 | 101958 | 127 | 50503018 |
Ileus | 68.39 | 12.75 | 107 | 101872 | 13122 | 50490023 |
Fibromyalgia | 68.38 | 12.75 | 6 | 101973 | 44972 | 50458173 |
Metastases to meninges | 67.57 | 12.75 | 45 | 101934 | 1957 | 50501188 |
Fingerprint loss | 66.81 | 12.75 | 15 | 101964 | 17 | 50503128 |
Suicidal ideation | 66.55 | 12.75 | 15 | 101964 | 55370 | 50447775 |
Bone pain | 65.58 | 12.75 | 227 | 101752 | 47002 | 50456143 |
Metastases to the mediastinum | 64.40 | 12.75 | 27 | 101952 | 443 | 50502702 |
Metastases to chest wall | 63.97 | 12.75 | 27 | 101952 | 451 | 50502694 |
Neoplasm malignant | 63.77 | 12.75 | 145 | 101834 | 23570 | 50479575 |
Injection site erythema | 63.46 | 12.75 | 36 | 101943 | 74900 | 50428245 |
Hypokalaemia | 63.43 | 12.75 | 347 | 101632 | 87645 | 50415500 |
Enterocolitis | 63.21 | 12.75 | 72 | 101907 | 6495 | 50496650 |
Abortion spontaneous | 62.36 | 12.75 | 6 | 101973 | 41766 | 50461379 |
Suicide attempt | 62.18 | 12.75 | 14 | 101965 | 51718 | 50451427 |
Hypersensitivity | 61.21 | 12.75 | 225 | 101754 | 214936 | 50288209 |
Gastrointestinal perforation | 60.81 | 12.75 | 50 | 101929 | 3011 | 50500134 |
Gamma-glutamyltransferase decreased | 60.49 | 12.75 | 23 | 101956 | 288 | 50502857 |
Mobility decreased | 60.07 | 12.75 | 44 | 101935 | 79904 | 50423241 |
Bone disorder | 59.99 | 12.75 | 123 | 101856 | 18629 | 50484516 |
Nail discolouration | 58.76 | 12.75 | 44 | 101935 | 2310 | 50500835 |
Somnolence | 58.54 | 12.75 | 142 | 101837 | 154843 | 50348302 |
Portal hypertension | 58.34 | 12.75 | 51 | 101928 | 3341 | 50499804 |
Tooth extraction | 57.85 | 12.75 | 81 | 101898 | 8994 | 50494151 |
Feeling abnormal | 55.70 | 12.75 | 105 | 101874 | 125387 | 50377758 |
Loss of personal independence in daily activities | 54.67 | 12.75 | 37 | 101942 | 70013 | 50433132 |
Insomnia | 53.66 | 12.75 | 177 | 101802 | 174688 | 50328457 |
Therapy change | 53.22 | 12.75 | 59 | 101920 | 5166 | 50497979 |
Chronic obstructive pulmonary disease | 52.39 | 12.75 | 21 | 101958 | 53414 | 50449731 |
Product use in unapproved indication | 52.20 | 12.75 | 96 | 101883 | 115723 | 50387422 |
Metastases to adrenals | 51.39 | 12.75 | 26 | 101953 | 668 | 50502477 |
Hypotension | 51.35 | 12.75 | 272 | 101707 | 235197 | 50267948 |
Plasma cell myeloma | 51.00 | 12.75 | 3 | 101976 | 31319 | 50471826 |
Hepatic failure | 50.90 | 12.75 | 162 | 101817 | 32121 | 50471024 |
Intestinal perforation | 50.38 | 12.75 | 82 | 101897 | 10397 | 50492748 |
Hypoalbuminaemia | 49.93 | 12.75 | 79 | 101900 | 9781 | 50493364 |
Product dose omission issue | 49.20 | 12.75 | 197 | 101782 | 183641 | 50319504 |
Pulmonary embolism | 49.00 | 12.75 | 362 | 101617 | 101342 | 50401803 |
Jaw operation | 48.53 | 12.75 | 26 | 101953 | 754 | 50502391 |
Wheezing | 48.12 | 12.75 | 33 | 101946 | 62014 | 50441131 |
General physical health deterioration | 47.50 | 12.75 | 467 | 101512 | 141967 | 50361178 |
Chronic kidney disease | 47.32 | 12.75 | 11 | 101968 | 39760 | 50463385 |
Nasal congestion | 47.08 | 12.75 | 22 | 101957 | 51098 | 50452047 |
Cardiac failure congestive | 46.57 | 12.75 | 61 | 101918 | 84321 | 50418824 |
Alopecia | 46.52 | 12.75 | 296 | 101683 | 244751 | 50258394 |
Hepatic enzyme increased | 46.44 | 12.75 | 133 | 101846 | 137247 | 50365898 |
Intentional product misuse | 46.42 | 12.75 | 18 | 101961 | 46716 | 50456429 |
Erythema | 46.39 | 12.75 | 475 | 101504 | 145939 | 50357206 |
Device related thrombosis | 45.62 | 12.75 | 30 | 101949 | 1277 | 50501868 |
Abdominal pain | 45.03 | 12.75 | 697 | 101282 | 235531 | 50267614 |
Skin hyperpigmentation | 44.40 | 12.75 | 54 | 101925 | 5222 | 50497923 |
Neoplasm | 44.03 | 12.75 | 57 | 101922 | 5871 | 50497274 |
Oxygen saturation decreased | 43.53 | 12.75 | 50 | 101929 | 73198 | 50429947 |
Debridement | 43.45 | 12.75 | 28 | 101951 | 1151 | 50501994 |
Lymphoedema | 43.34 | 12.75 | 71 | 101908 | 9051 | 50494094 |
Leukoencephalopathy | 43.31 | 12.75 | 46 | 101933 | 3837 | 50499308 |
Hyperhidrosis | 43.14 | 12.75 | 71 | 101908 | 89355 | 50413790 |
Hypoaesthesia | 42.79 | 12.75 | 418 | 101561 | 126839 | 50376306 |
Platelet count decreased | 42.69 | 12.75 | 348 | 101631 | 100378 | 50402767 |
Lacrimation increased | 42.51 | 12.75 | 101 | 101878 | 16891 | 50486254 |
Blood pressure fluctuation | 42.44 | 12.75 | 10 | 101969 | 35813 | 50467332 |
Peripheral sensory neuropathy | 42.27 | 12.75 | 59 | 101920 | 6532 | 50496613 |
Drug intolerance | 41.91 | 12.75 | 264 | 101715 | 218840 | 50284305 |
Pyogenic granuloma | 41.17 | 12.75 | 17 | 101962 | 268 | 50502877 |
Wrong technique in product usage process | 41.11 | 12.75 | 31 | 101948 | 55479 | 50447666 |
Osteolysis | 41.10 | 12.75 | 37 | 101942 | 2520 | 50500625 |
Migraine | 40.95 | 12.75 | 55 | 101924 | 75225 | 50427920 |
Folliculitis | 40.83 | 12.75 | 14 | 101965 | 39211 | 50463934 |
Nail infection | 40.70 | 12.75 | 33 | 101946 | 1948 | 50501197 |
Angina bullosa haemorrhagica | 40.56 | 12.75 | 14 | 101965 | 130 | 50503015 |
Blood uric acid decreased | 40.38 | 12.75 | 22 | 101957 | 660 | 50502485 |
Drug reaction with eosinophilia and systemic symptoms | 40.10 | 12.75 | 5 | 101974 | 28419 | 50474726 |
Pericardial effusion | 39.97 | 12.75 | 128 | 101851 | 25461 | 50477684 |
Recurrent cancer | 39.80 | 12.75 | 31 | 101948 | 1726 | 50501419 |
Performance status decreased | 39.51 | 12.75 | 40 | 101939 | 3155 | 50499990 |
Bone sequestrum | 39.48 | 12.75 | 28 | 101951 | 1350 | 50501795 |
Agitation | 39.30 | 12.75 | 30 | 101949 | 53354 | 50449791 |
Mucosal toxicity | 39.17 | 12.75 | 17 | 101962 | 305 | 50502840 |
Colon cancer metastatic | 39.07 | 12.75 | 25 | 101954 | 1015 | 50502130 |
Disseminated intravascular coagulation | 38.78 | 12.75 | 98 | 101881 | 17037 | 50486108 |
Plantar erythema | 38.07 | 12.75 | 15 | 101964 | 208 | 50502937 |
Blood glucose increased | 37.90 | 12.75 | 53 | 101926 | 71271 | 50431874 |
Urinary tract infection | 37.37 | 12.75 | 281 | 101698 | 223739 | 50279406 |
Cardiac output decreased | 37.24 | 12.75 | 23 | 101956 | 877 | 50502268 |
Rhabdomyolysis | 37.19 | 12.75 | 16 | 101963 | 39011 | 50464134 |
Hyperkalaemia | 36.73 | 12.75 | 26 | 101953 | 48063 | 50455082 |
Acute kidney injury | 36.66 | 12.75 | 289 | 101690 | 227769 | 50275376 |
Cold dysaesthesia | 36.14 | 12.75 | 8 | 101971 | 8 | 50503137 |
Osteoporosis | 35.97 | 12.75 | 23 | 101956 | 44856 | 50458289 |
Ejection fraction | 35.82 | 12.75 | 25 | 101954 | 1175 | 50501970 |
Malignant ascites | 35.81 | 12.75 | 22 | 101957 | 831 | 50502314 |
Cataract | 35.57 | 12.75 | 26 | 101953 | 47274 | 50455871 |
Infusion site induration | 35.34 | 12.75 | 22 | 101957 | 851 | 50502294 |
Dysaesthesia | 34.35 | 12.75 | 40 | 101939 | 3695 | 50499450 |
Pharyngeal inflammation | 34.20 | 12.75 | 19 | 101960 | 593 | 50502552 |
Hypovolaemic shock | 34.11 | 12.75 | 47 | 101932 | 5141 | 50498004 |
Anxiety | 33.95 | 12.75 | 214 | 101765 | 177392 | 50325753 |
Necrotising oesophagitis | 33.75 | 12.75 | 11 | 101968 | 84 | 50503061 |
Periodontitis | 33.60 | 12.75 | 36 | 101943 | 3033 | 50500112 |
Eosinophil percentage increased | 33.46 | 12.75 | 22 | 101957 | 936 | 50502209 |
Gingival bleeding | 33.44 | 12.75 | 72 | 101907 | 11281 | 50491864 |
Mouth ulceration | 33.24 | 12.75 | 128 | 101851 | 27896 | 50475249 |
Exposed bone in jaw | 32.71 | 12.75 | 34 | 101945 | 2766 | 50500379 |
Blood creatinine decreased | 32.59 | 12.75 | 45 | 101934 | 4931 | 50498214 |
Proteinuria | 32.55 | 12.75 | 90 | 101889 | 16507 | 50486638 |
Blood cholesterol increased | 32.47 | 12.75 | 38 | 101941 | 55177 | 50447968 |
Therapy partial responder | 32.26 | 12.75 | 52 | 101927 | 6539 | 50496606 |
Drug ineffective for unapproved indication | 31.91 | 12.75 | 3 | 101976 | 21278 | 50481867 |
Nodular regenerative hyperplasia | 31.91 | 12.75 | 14 | 101965 | 258 | 50502887 |
Radiation necrosis | 31.85 | 12.75 | 15 | 101964 | 328 | 50502817 |
Adverse event | 31.70 | 12.75 | 25 | 101954 | 43738 | 50459407 |
Hiccups | 31.64 | 12.75 | 27 | 101952 | 1712 | 50501433 |
Metastases to ovary | 31.56 | 12.75 | 15 | 101964 | 335 | 50502810 |
Superior vena cava syndrome | 31.54 | 12.75 | 18 | 101961 | 592 | 50502553 |
Premature delivery | 31.42 | 12.75 | 5 | 101974 | 23658 | 50479487 |
Ear infection | 31.26 | 12.75 | 7 | 101972 | 25963 | 50477182 |
Brachiocephalic vein thrombosis | 31.20 | 12.75 | 10 | 101969 | 72 | 50503073 |
Onychomadesis | 31.08 | 12.75 | 37 | 101942 | 3499 | 50499646 |
Contusion | 30.76 | 12.75 | 119 | 101860 | 112064 | 50391081 |
Therapy interrupted | 30.74 | 12.75 | 100 | 101879 | 20052 | 50483093 |
Tumour pain | 30.72 | 12.75 | 23 | 101956 | 1207 | 50501938 |
Lymphadenopathy | 30.38 | 12.75 | 141 | 101838 | 33358 | 50469787 |
Loss of consciousness | 30.38 | 12.75 | 108 | 101871 | 104245 | 50398900 |
Accidental exposure to product | 30.33 | 12.75 | 5 | 101974 | 23052 | 50480093 |
Sedation | 30.05 | 12.75 | 12 | 101967 | 30598 | 50472547 |
Blood pressure systolic increased | 30.05 | 12.75 | 17 | 101962 | 35432 | 50467713 |
Foetal exposure during pregnancy | 29.83 | 12.75 | 9 | 101970 | 27350 | 50475795 |
Hydronephrosis | 29.68 | 12.75 | 58 | 101921 | 8483 | 50494662 |
Toothache | 29.63 | 12.75 | 88 | 101891 | 16806 | 50486339 |
Sopor | 29.29 | 12.75 | 3 | 101976 | 19876 | 50483269 |
Confusional state | 29.23 | 12.75 | 237 | 101742 | 185691 | 50317454 |
Pigmentation disorder | 29.22 | 12.75 | 37 | 101942 | 3727 | 50499418 |
Hypophagia | 29.16 | 12.75 | 122 | 101857 | 27606 | 50475539 |
Anastomotic leak | 29.11 | 12.75 | 15 | 101964 | 401 | 50502744 |
Central nervous system lesion | 28.89 | 12.75 | 61 | 101918 | 9428 | 50493717 |
Abnormal behaviour | 28.88 | 12.75 | 3 | 101976 | 19655 | 50483490 |
Myocardial infarction | 28.76 | 12.75 | 88 | 101891 | 88939 | 50414206 |
Malignant pleural effusion | 28.50 | 12.75 | 29 | 101950 | 2301 | 50500844 |
Biliary sepsis | 28.43 | 12.75 | 19 | 101960 | 831 | 50502314 |
Injury | 28.42 | 12.75 | 34 | 101945 | 48891 | 50454254 |
Pregnancy | 28.38 | 12.75 | 12 | 101967 | 29565 | 50473580 |
Cachexia | 28.21 | 12.75 | 40 | 101939 | 4493 | 50498652 |
Injection site bruising | 27.92 | 12.75 | 20 | 101959 | 36748 | 50466397 |
Subacute cutaneous lupus erythematosus | 27.88 | 12.75 | 28 | 101951 | 2187 | 50500958 |
Anastomotic fistula | 27.87 | 12.75 | 7 | 101972 | 17 | 50503128 |
Pulmonary mass | 27.80 | 12.75 | 92 | 101887 | 18613 | 50484532 |
Human epidermal growth factor receptor negative | 27.63 | 12.75 | 6 | 101973 | 5 | 50503140 |
Varices oesophageal | 27.56 | 12.75 | 31 | 101948 | 2758 | 50500387 |
Peripheral swelling | 27.35 | 12.75 | 274 | 101705 | 205662 | 50297483 |
Cheilitis | 27.26 | 12.75 | 35 | 101944 | 3575 | 50499570 |
Bone debridement | 27.02 | 12.75 | 12 | 101967 | 228 | 50502917 |
Nervousness | 26.89 | 12.75 | 11 | 101968 | 27640 | 50475505 |
Stress cardiomyopathy | 26.73 | 12.75 | 53 | 101926 | 7834 | 50495311 |
Sequestrectomy | 26.72 | 12.75 | 18 | 101961 | 798 | 50502347 |
Hypervolaemia | 26.72 | 12.75 | 9 | 101970 | 25490 | 50477655 |
Pancreatic fistula | 26.63 | 12.75 | 6 | 101973 | 7 | 50503138 |
Asthenopia | 26.54 | 12.75 | 26 | 101953 | 1971 | 50501174 |
Neoplasm recurrence | 26.31 | 12.75 | 28 | 101951 | 2341 | 50500804 |
Colorectal cancer metastatic | 26.10 | 12.75 | 15 | 101964 | 500 | 50502645 |
Constipation | 26.06 | 12.75 | 522 | 101457 | 185186 | 50317959 |
Heart rate increased | 25.94 | 12.75 | 75 | 101904 | 77175 | 50425970 |
Multiple sclerosis | 25.75 | 12.75 | 5 | 101974 | 20488 | 50482657 |
Incorrect dose administered | 25.69 | 12.75 | 36 | 101943 | 48378 | 50454767 |
Dermatitis acneiform | 25.54 | 12.75 | 36 | 101943 | 4021 | 50499124 |
Pneumatosis intestinalis | 25.41 | 12.75 | 26 | 101953 | 2077 | 50501068 |
Atrial fibrillation | 25.35 | 12.75 | 112 | 101867 | 101633 | 50401512 |
Vessel puncture site bruise | 25.21 | 12.75 | 13 | 101966 | 348 | 50502797 |
Early satiety | 25.21 | 12.75 | 17 | 101962 | 755 | 50502390 |
Injection site haemorrhage | 25.20 | 12.75 | 6 | 101973 | 21340 | 50481805 |
Tooth erosion | 25.20 | 12.75 | 14 | 101965 | 437 | 50502708 |
White blood cell count decreased | 25.18 | 12.75 | 352 | 101627 | 116370 | 50386775 |
Gastric perforation | 25.08 | 12.75 | 22 | 101957 | 1448 | 50501697 |
Recall phenomenon | 25.04 | 12.75 | 15 | 101964 | 541 | 50502604 |
Treatment noncompliance | 24.79 | 12.75 | 15 | 101964 | 30135 | 50473010 |
Vascular pain | 24.63 | 12.75 | 16 | 101963 | 667 | 50502478 |
Fluid retention | 24.62 | 12.75 | 40 | 101939 | 50609 | 50452536 |
Respiratory arrest | 24.57 | 12.75 | 15 | 101964 | 29994 | 50473151 |
Granulocyte count decreased | 24.54 | 12.75 | 17 | 101962 | 789 | 50502356 |
Tumour perforation | 24.48 | 12.75 | 9 | 101970 | 102 | 50503043 |
Product quality issue | 24.48 | 12.75 | 16 | 101963 | 30842 | 50472303 |
Stridor | 24.37 | 12.75 | 31 | 101948 | 3138 | 50500007 |
Limbal stem cell deficiency | 24.37 | 12.75 | 6 | 101973 | 13 | 50503132 |
Ataxia | 24.36 | 12.75 | 72 | 101907 | 13714 | 50489431 |
Steatohepatitis | 24.35 | 12.75 | 14 | 101965 | 467 | 50502678 |
Adnexa uteri mass | 24.33 | 12.75 | 14 | 101965 | 468 | 50502677 |
Hyperaesthesia | 24.26 | 12.75 | 52 | 101927 | 8121 | 50495024 |
Hormone receptor positive breast cancer | 24.22 | 12.75 | 14 | 101965 | 472 | 50502673 |
Unresponsive to stimuli | 24.10 | 12.75 | 16 | 101963 | 30593 | 50472552 |
Failure to anastomose | 24.06 | 12.75 | 6 | 101973 | 14 | 50503131 |
Pleural neoplasm | 23.81 | 12.75 | 11 | 101968 | 230 | 50502915 |
Acute coronary syndrome | 23.75 | 12.75 | 56 | 101923 | 9318 | 50493827 |
Oesophagitis | 23.74 | 12.75 | 70 | 101909 | 13313 | 50489832 |
Vasodilatation | 23.67 | 12.75 | 26 | 101953 | 2253 | 50500892 |
Arterial thrombosis | 23.59 | 12.75 | 20 | 101959 | 1257 | 50501888 |
Ingrowing nail | 23.55 | 12.75 | 24 | 101955 | 1908 | 50501237 |
Adenocarcinoma | 23.54 | 12.75 | 27 | 101952 | 2454 | 50500691 |
Radiation skin injury | 23.50 | 12.75 | 17 | 101962 | 846 | 50502299 |
Depressed level of consciousness | 23.45 | 12.75 | 43 | 101936 | 51910 | 50451235 |
Pulmonary arterial hypertension | 23.43 | 12.75 | 6 | 101973 | 20313 | 50482832 |
Neutrophil count decreased | 23.40 | 12.75 | 166 | 101813 | 45860 | 50457285 |
Dysphagia | 23.35 | 12.75 | 249 | 101730 | 77269 | 50425876 |
Brain operation | 23.27 | 12.75 | 14 | 101965 | 509 | 50502636 |
Pulmonary hypertension | 23.07 | 12.75 | 20 | 101959 | 33397 | 50469748 |
Metastases to eye | 22.96 | 12.75 | 9 | 101970 | 123 | 50503022 |
Staphylococcal infection | 22.61 | 12.75 | 23 | 101956 | 35593 | 50467552 |
Schistosomiasis | 22.59 | 12.75 | 5 | 101974 | 5 | 50503140 |
Increased liver stiffness | 22.59 | 12.75 | 5 | 101974 | 5 | 50503140 |
Hepatic atrophy | 22.39 | 12.75 | 11 | 101968 | 265 | 50502880 |
Dental care | 22.33 | 12.75 | 17 | 101962 | 915 | 50502230 |
Transaminases | 22.30 | 12.75 | 8 | 101971 | 84 | 50503061 |
Joint injury | 22.29 | 12.75 | 8 | 101971 | 21781 | 50481364 |
Nightmare | 22.28 | 12.75 | 3 | 101976 | 16083 | 50487062 |
Motion sickness | 22.26 | 12.75 | 16 | 101963 | 788 | 50502357 |
Cholangitis | 22.24 | 12.75 | 36 | 101943 | 4543 | 50498602 |
Irritability | 22.19 | 12.75 | 15 | 101964 | 28411 | 50474734 |
Blood lactate dehydrogenase increased | 22.10 | 12.75 | 88 | 101891 | 19474 | 50483671 |
Fatigue | 22.05 | 12.75 | 1682 | 100297 | 705919 | 49797226 |
Post-traumatic neck syndrome | 21.97 | 12.75 | 23 | 101956 | 1887 | 50501258 |
Right ventricular failure | 21.93 | 12.75 | 3 | 101976 | 15890 | 50487255 |
Pulpitis dental | 21.75 | 12.75 | 16 | 101963 | 817 | 50502328 |
Vertebral column mass | 21.73 | 12.75 | 9 | 101970 | 143 | 50503002 |
Oral pigmentation | 21.68 | 12.75 | 5 | 101974 | 7 | 50503138 |
Brain neoplasm | 21.60 | 12.75 | 32 | 101947 | 3741 | 50499404 |
Diverticulitis | 21.56 | 12.75 | 21 | 101958 | 33161 | 50469984 |
Foot deformity | 21.53 | 12.75 | 6 | 101973 | 19204 | 50483941 |
Muscle swelling | 21.50 | 12.75 | 12 | 101967 | 378 | 50502767 |
Caesarean section | 21.46 | 12.75 | 3 | 101976 | 15636 | 50487509 |
Nephrolithiasis | 21.35 | 12.75 | 23 | 101956 | 34670 | 50468475 |
Dermatomyositis | 21.32 | 12.75 | 24 | 101955 | 2137 | 50501008 |
Cytomegalovirus infection | 21.30 | 12.75 | 5 | 101974 | 17957 | 50485188 |
Gingivitis | 21.23 | 12.75 | 46 | 101933 | 7238 | 50495907 |
Body temperature decreased | 21.20 | 12.75 | 77 | 101902 | 16318 | 50486827 |
Disturbance in attention | 21.13 | 12.75 | 19 | 101960 | 31167 | 50471978 |
Inappropriate schedule of product administration | 21.13 | 12.75 | 74 | 101905 | 71757 | 50431388 |
Breast neoplasm | 21.10 | 12.75 | 19 | 101960 | 1294 | 50501851 |
Biliary obstruction | 20.97 | 12.75 | 25 | 101954 | 2368 | 50500777 |
Epistaxis | 20.95 | 12.75 | 209 | 101770 | 63745 | 50439400 |
Oral toxicity | 20.84 | 12.75 | 4 | 101975 | 0 | 50503145 |
Radiation myelopathy | 20.84 | 12.75 | 4 | 101975 | 0 | 50503145 |
Computerised tomogram abnormal | 20.77 | 12.75 | 23 | 101956 | 2011 | 50501134 |
Myalgia | 20.67 | 12.75 | 156 | 101823 | 124163 | 50378982 |
Lactic acidosis | 20.66 | 12.75 | 22 | 101957 | 33333 | 50469812 |
No adverse event | 20.64 | 12.75 | 127 | 101852 | 33451 | 50469694 |
Hand-foot-and-mouth disease | 20.50 | 12.75 | 8 | 101971 | 108 | 50503037 |
Injection site swelling | 20.29 | 12.75 | 33 | 101946 | 41740 | 50461405 |
Oral pain | 20.27 | 12.75 | 102 | 101877 | 24931 | 50478214 |
Coronary artery disease | 20.27 | 12.75 | 18 | 101961 | 29708 | 50473437 |
Acute respiratory failure | 20.15 | 12.75 | 17 | 101962 | 28765 | 50474380 |
ECG signs of myocardial ischaemia | 20.09 | 12.75 | 7 | 101972 | 67 | 50503078 |
Hip arthroplasty | 20.07 | 12.75 | 19 | 101960 | 30410 | 50472735 |
Crying | 20.05 | 12.75 | 8 | 101971 | 20408 | 50482737 |
Hepatic cancer metastatic | 20.01 | 12.75 | 11 | 101968 | 336 | 50502809 |
Lymphadenopathy mediastinal | 20.00 | 12.75 | 25 | 101954 | 2486 | 50500659 |
Respiratory disorder | 19.96 | 12.75 | 20 | 101959 | 31167 | 50471978 |
Type 2 diabetes mellitus | 19.84 | 12.75 | 24 | 101955 | 34351 | 50468794 |
Congestive cardiomyopathy | 19.82 | 12.75 | 38 | 101941 | 5480 | 50497665 |
Evans syndrome | 19.75 | 12.75 | 9 | 101970 | 182 | 50502963 |
Gait disturbance | 19.73 | 12.75 | 200 | 101779 | 149805 | 50353340 |
Subileus | 19.67 | 12.75 | 26 | 101953 | 2733 | 50500412 |
Acute myeloid leukaemia | 19.66 | 12.75 | 71 | 101908 | 15003 | 50488142 |
Metastases to stomach | 19.66 | 12.75 | 9 | 101970 | 184 | 50502961 |
Prescribed overdose | 19.58 | 12.75 | 3 | 101976 | 14597 | 50488548 |
Oncologic complication | 19.50 | 12.75 | 8 | 101971 | 124 | 50503021 |
Blood pressure increased | 19.43 | 12.75 | 173 | 101806 | 132959 | 50370186 |
Ankle fracture | 19.41 | 12.75 | 4 | 101975 | 15718 | 50487427 |
Diabetes mellitus | 19.23 | 12.75 | 44 | 101935 | 48989 | 50454156 |
Metastases to breast | 19.21 | 12.75 | 10 | 101969 | 273 | 50502872 |
Cardio-respiratory arrest | 19.07 | 12.75 | 51 | 101928 | 53841 | 50449304 |
Eosinophilia | 18.83 | 12.75 | 7 | 101972 | 18645 | 50484500 |
Odynophagia | 18.75 | 12.75 | 41 | 101938 | 6491 | 50496654 |
Hyperglycaemic hyperosmolar nonketotic syndrome | 18.70 | 12.75 | 13 | 101966 | 607 | 50502538 |
Mucosal disorder | 18.62 | 12.75 | 21 | 101958 | 1874 | 50501271 |
Paraneoplastic dermatomyositis | 18.60 | 12.75 | 4 | 101975 | 3 | 50503142 |
Disease recurrence | 18.56 | 12.75 | 85 | 101894 | 19996 | 50483149 |
Thrombosis | 18.55 | 12.75 | 183 | 101796 | 55650 | 50447495 |
Diarrhoea haemorrhagic | 18.53 | 12.75 | 45 | 101934 | 7630 | 50495515 |
Brain oedema | 18.52 | 12.75 | 61 | 101918 | 12309 | 50490836 |
Eye pain | 18.49 | 12.75 | 18 | 101961 | 28431 | 50474714 |
Metastases to thorax | 18.39 | 12.75 | 9 | 101970 | 215 | 50502930 |
Hepatic neoplasm | 18.31 | 12.75 | 20 | 101959 | 1722 | 50501423 |
Purulent discharge | 18.30 | 12.75 | 32 | 101947 | 4300 | 50498845 |
Femoral artery embolism | 18.28 | 12.75 | 6 | 101973 | 47 | 50503098 |
Pelvic fluid collection | 18.14 | 12.75 | 14 | 101965 | 769 | 50502376 |
Angioedema | 18.08 | 12.75 | 30 | 101949 | 37646 | 50465499 |
Radiation fibrosis - lung | 18.04 | 12.75 | 5 | 101974 | 20 | 50503125 |
Medication error | 18.03 | 12.75 | 28 | 101951 | 36076 | 50467069 |
Mental disorder | 17.99 | 12.75 | 11 | 101968 | 21980 | 50481165 |
Carcinoid tumour pulmonary | 17.99 | 12.75 | 11 | 101968 | 412 | 50502733 |
Chemical peritonitis | 17.97 | 12.75 | 7 | 101972 | 94 | 50503051 |
Haematoma | 17.93 | 12.75 | 21 | 101958 | 30489 | 50472656 |
Small intestinal obstruction | 17.93 | 12.75 | 72 | 101907 | 15996 | 50487149 |
Neutropenic sepsis | 17.92 | 12.75 | 66 | 101913 | 14081 | 50489064 |
Sudden death | 17.87 | 12.75 | 49 | 101930 | 8942 | 50494203 |
Peripheral motor neuropathy | 17.85 | 12.75 | 18 | 101961 | 1413 | 50501732 |
Product prescribing error | 17.84 | 12.75 | 10 | 101969 | 20951 | 50482194 |
Dyschezia | 17.74 | 12.75 | 20 | 101959 | 1784 | 50501361 |
Psychotic disorder | 17.72 | 12.75 | 11 | 101968 | 21801 | 50481344 |
Carbohydrate antigen 19-9 increased | 17.69 | 12.75 | 8 | 101971 | 159 | 50502986 |
Retroperitoneal neoplasm metastatic | 17.66 | 12.75 | 5 | 101974 | 22 | 50503123 |
Calcium ionised increased | 17.64 | 12.75 | 7 | 101972 | 99 | 50503046 |
Pericardial effusion malignant | 17.58 | 12.75 | 7 | 101972 | 100 | 50503045 |
Pneumocystis jirovecii pneumonia | 17.55 | 12.75 | 4 | 101975 | 14659 | 50488486 |
Hypothalamo-pituitary disorder | 17.50 | 12.75 | 13 | 101966 | 674 | 50502471 |
Skin disorder | 17.45 | 12.75 | 95 | 101884 | 23935 | 50479210 |
Tumour invasion | 17.45 | 12.75 | 7 | 101972 | 102 | 50503043 |
Gallbladder disorder | 17.38 | 12.75 | 6 | 101973 | 16736 | 50486409 |
Dysgeusia | 17.31 | 12.75 | 136 | 101843 | 38780 | 50464365 |
Pneumonitis | 17.14 | 12.75 | 110 | 101869 | 29400 | 50473745 |
Hallucination, visual | 17.12 | 12.75 | 6 | 101973 | 16576 | 50486569 |
Vein disorder | 17.08 | 12.75 | 31 | 101948 | 4288 | 50498857 |
Anaphylactic reaction | 17.05 | 12.75 | 54 | 101925 | 54001 | 50449144 |
Joint range of motion decreased | 16.99 | 12.75 | 8 | 101971 | 18504 | 50484641 |
Botryomycosis | 16.98 | 12.75 | 5 | 101974 | 26 | 50503119 |
Gastroenteropancreatic neuroendocrine tumour disease | 16.98 | 12.75 | 5 | 101974 | 26 | 50503119 |
Gastrointestinal inflammation | 16.92 | 12.75 | 32 | 101947 | 4568 | 50498577 |
Brachial plexopathy | 16.86 | 12.75 | 7 | 101972 | 112 | 50503033 |
Oral disorder | 16.86 | 12.75 | 44 | 101935 | 7800 | 50495345 |
Dermatitis | 16.82 | 12.75 | 65 | 101914 | 14186 | 50488959 |
Artificial menopause | 16.82 | 12.75 | 5 | 101974 | 27 | 50503118 |
Enterocolitis haemorrhagic | 16.80 | 12.75 | 17 | 101962 | 1340 | 50501805 |
Respiratory tract congestion | 16.75 | 12.75 | 4 | 101975 | 14195 | 50488950 |
Anal erythema | 16.74 | 12.75 | 8 | 101971 | 181 | 50502964 |
Premature baby | 16.72 | 12.75 | 8 | 101971 | 18329 | 50484816 |
Herpangina | 16.67 | 12.75 | 5 | 101974 | 28 | 50503117 |
C-reactive protein increased | 16.66 | 12.75 | 73 | 101906 | 66401 | 50436744 |
Tubulointerstitial nephritis | 16.59 | 12.75 | 5 | 101974 | 15206 | 50487939 |
Bone fistula | 16.48 | 12.75 | 6 | 101973 | 66 | 50503079 |
Tremor | 16.46 | 12.75 | 150 | 101829 | 114753 | 50388392 |
Excessive granulation tissue | 16.41 | 12.75 | 13 | 101966 | 742 | 50502403 |
Hypertriglyceridaemia | 16.37 | 12.75 | 35 | 101944 | 5456 | 50497689 |
Sinus congestion | 16.35 | 12.75 | 4 | 101975 | 13967 | 50489178 |
Rectal perforation | 16.34 | 12.75 | 10 | 101969 | 375 | 50502770 |
Hyperammonaemia | 16.32 | 12.75 | 32 | 101947 | 4692 | 50498453 |
Anastomotic complication | 16.31 | 12.75 | 7 | 101972 | 122 | 50503023 |
Hepatic cancer | 16.25 | 12.75 | 26 | 101953 | 3249 | 50499896 |
Tongue discolouration | 16.23 | 12.75 | 24 | 101955 | 2800 | 50500345 |
Thyroid disorder | 16.12 | 12.75 | 3 | 101976 | 12674 | 50490471 |
Procedural pain | 16.11 | 12.75 | 4 | 101975 | 13828 | 50489317 |
Delirium | 16.03 | 12.75 | 33 | 101946 | 38159 | 50464986 |
Breast disorder | 15.90 | 12.75 | 20 | 101959 | 2002 | 50501143 |
Radioisotope scan | 15.85 | 12.75 | 4 | 101975 | 10 | 50503135 |
Renal vein thrombosis | 15.83 | 12.75 | 9 | 101970 | 294 | 50502851 |
Myopathy toxic | 15.78 | 12.75 | 10 | 101969 | 399 | 50502746 |
Impaired work ability | 15.78 | 12.75 | 4 | 101975 | 13636 | 50489509 |
Bone cancer metastatic | 15.76 | 12.75 | 7 | 101972 | 133 | 50503012 |
Sciatica | 15.75 | 12.75 | 12 | 101967 | 21370 | 50481775 |
Blood creatine phosphokinase increased | 15.66 | 12.75 | 18 | 101961 | 26349 | 50476796 |
Facial asymmetry | 15.63 | 12.75 | 12 | 101967 | 654 | 50502491 |
Hyperchylomicronaemia | 15.63 | 12.75 | 3 | 101976 | 0 | 50503145 |
Chemotherapy cardiotoxicity attenuation | 15.63 | 12.75 | 3 | 101976 | 0 | 50503145 |
Metastases to muscle | 15.62 | 12.75 | 7 | 101972 | 136 | 50503009 |
Metastases to abdominal cavity | 15.61 | 12.75 | 10 | 101969 | 407 | 50502738 |
Hypermutation | 15.60 | 12.75 | 5 | 101974 | 36 | 50503109 |
Perforation | 15.59 | 12.75 | 14 | 101965 | 950 | 50502195 |
Hyperbaric oxygen therapy | 15.48 | 12.75 | 5 | 101974 | 37 | 50503108 |
Cognitive disorder | 15.43 | 12.75 | 42 | 101937 | 44081 | 50459064 |
Radiation injury | 15.37 | 12.75 | 10 | 101969 | 418 | 50502727 |
Tenderness | 15.28 | 12.75 | 76 | 101903 | 18489 | 50484656 |
Drug level increased | 15.27 | 12.75 | 10 | 101969 | 19258 | 50483887 |
Catheter site bruise | 15.21 | 12.75 | 9 | 101970 | 317 | 50502828 |
Restlessness | 15.15 | 12.75 | 17 | 101962 | 25156 | 50477989 |
Ejection fraction abnormal | 15.10 | 12.75 | 13 | 101966 | 834 | 50502311 |
Influenza like illness | 15.08 | 12.75 | 62 | 101917 | 57397 | 50445748 |
Obstruction gastric | 15.08 | 12.75 | 13 | 101966 | 836 | 50502309 |
Large intestine perforation | 15.05 | 12.75 | 41 | 101938 | 7453 | 50495692 |
Liver scan abnormal | 15.03 | 12.75 | 5 | 101974 | 41 | 50503104 |
Gram stain positive | 15.03 | 12.75 | 5 | 101974 | 41 | 50503104 |
Upper respiratory tract infection | 14.96 | 12.75 | 75 | 101904 | 65823 | 50437322 |
Vulval disorder | 14.95 | 12.75 | 12 | 101967 | 698 | 50502447 |
Hepatotoxicity | 14.90 | 12.75 | 100 | 101879 | 27126 | 50476019 |
Pulmonary thrombosis | 14.89 | 12.75 | 41 | 101938 | 7500 | 50495645 |
Electrocardiogram QT prolonged | 14.89 | 12.75 | 54 | 101925 | 51832 | 50451313 |
Pituitary tumour | 14.86 | 12.75 | 13 | 101966 | 852 | 50502293 |
Cardiac arrest | 14.85 | 12.75 | 103 | 101876 | 83548 | 50419597 |
Abdominal symptom | 14.79 | 12.75 | 9 | 101970 | 334 | 50502811 |
Corneal erosion | 14.78 | 12.75 | 8 | 101971 | 237 | 50502908 |
Neck pain | 14.71 | 12.75 | 62 | 101917 | 57005 | 50446140 |
Ileus paralytic | 14.68 | 12.75 | 28 | 101951 | 4022 | 50499123 |
Skin reaction | 14.68 | 12.75 | 54 | 101925 | 11514 | 50491631 |
Venous thrombosis limb | 14.67 | 12.75 | 22 | 101957 | 2600 | 50500545 |
Torsade de pointes | 14.63 | 12.75 | 3 | 101976 | 11832 | 50491313 |
Fistula | 14.59 | 12.75 | 43 | 101936 | 8175 | 50494970 |
Hypoglycaemia | 14.57 | 12.75 | 57 | 101922 | 53524 | 50449621 |
Metastases to heart | 14.53 | 12.75 | 5 | 101974 | 46 | 50503099 |
Extrapyramidal disorder | 14.52 | 12.75 | 3 | 101976 | 11767 | 50491378 |
Mood swings | 14.48 | 12.75 | 7 | 101972 | 15947 | 50487198 |
Hallucination | 14.44 | 12.75 | 47 | 101932 | 46610 | 50456535 |
Restless legs syndrome | 14.39 | 12.75 | 7 | 101972 | 15890 | 50487255 |
Iron deficiency anaemia | 14.37 | 12.75 | 8 | 101971 | 16826 | 50486319 |
Accidental overdose | 14.34 | 12.75 | 11 | 101968 | 19522 | 50483623 |
Mediastinal disorder | 14.32 | 12.75 | 9 | 101970 | 354 | 50502791 |
Meningism | 14.32 | 12.75 | 9 | 101970 | 354 | 50502791 |
Glomerular filtration rate decreased | 14.31 | 12.75 | 3 | 101976 | 11649 | 50491496 |
Bile duct stenosis | 14.28 | 12.75 | 14 | 101965 | 1062 | 50502083 |
Metastases to pelvis | 14.28 | 12.75 | 9 | 101970 | 356 | 50502789 |
Swelling face | 14.27 | 12.75 | 56 | 101923 | 52539 | 50450606 |
Ureteric obstruction | 14.25 | 12.75 | 17 | 101962 | 1611 | 50501534 |
Blood iron decreased | 14.25 | 12.75 | 3 | 101976 | 11612 | 50491533 |
Breast cancer female | 14.24 | 12.75 | 38 | 101941 | 6824 | 50496321 |
Renal hydrocele | 14.24 | 12.75 | 4 | 101975 | 17 | 50503128 |
Lip pain | 14.20 | 12.75 | 17 | 101962 | 1617 | 50501528 |
Abdominal distension | 14.19 | 12.75 | 216 | 101763 | 72687 | 50430458 |
Anaemia | 14.15 | 12.75 | 633 | 101346 | 251823 | 50251322 |
Aggression | 14.14 | 12.75 | 13 | 101966 | 21103 | 50482042 |
Limb injury | 14.12 | 12.75 | 12 | 101967 | 20238 | 50482907 |
Metastases to bladder | 14.12 | 12.75 | 7 | 101972 | 172 | 50502973 |
Keratitis | 14.11 | 12.75 | 21 | 101958 | 2464 | 50500681 |
Wound treatment | 14.05 | 12.75 | 7 | 101972 | 174 | 50502971 |
Pulmonary hilum mass | 14.01 | 12.75 | 6 | 101973 | 104 | 50503041 |
Tumour excision | 14.01 | 12.75 | 9 | 101970 | 368 | 50502777 |
Obstructive airways disorder | 14.01 | 12.75 | 7 | 101972 | 15645 | 50487500 |
Product complaint | 13.98 | 12.75 | 3 | 101976 | 11463 | 50491682 |
Hyperglycaemia | 13.94 | 12.75 | 123 | 101856 | 36282 | 50466863 |
Hypothyroidism | 13.89 | 12.75 | 30 | 101949 | 34095 | 50469050 |
Peritoneal fluid analysis abnormal | 13.88 | 12.75 | 4 | 101975 | 19 | 50503126 |
Full blood count abnormal | 13.85 | 12.75 | 16 | 101963 | 23372 | 50479773 |
Heavy menstrual bleeding | 13.83 | 12.75 | 7 | 101972 | 15530 | 50487615 |
Small intestinal perforation | 13.81 | 12.75 | 15 | 101964 | 1283 | 50501862 |
Weight decreased | 13.80 | 12.75 | 561 | 101418 | 220684 | 50282461 |
Onychalgia | 13.77 | 12.75 | 12 | 101967 | 783 | 50502362 |
Infusion site haemorrhage | 13.76 | 12.75 | 23 | 101956 | 2981 | 50500164 |
Activated PI3 kinase delta syndrome | 13.71 | 12.75 | 4 | 101975 | 20 | 50503125 |
Actinomycosis | 13.60 | 12.75 | 13 | 101966 | 956 | 50502189 |
Metastases to kidney | 13.59 | 12.75 | 7 | 101972 | 187 | 50502958 |
Sputum discoloured | 13.57 | 12.75 | 5 | 101974 | 13390 | 50489755 |
Malignant peritoneal neoplasm | 13.56 | 12.75 | 11 | 101968 | 650 | 50502495 |
Anxiety disorder due to a general medical condition | 13.55 | 12.75 | 3 | 101976 | 3 | 50503142 |
Abdominal wall mass | 13.55 | 12.75 | 3 | 101976 | 3 | 50503142 |
Macular degeneration | 13.55 | 12.75 | 6 | 101973 | 14382 | 50488763 |
Stress | 13.52 | 12.75 | 59 | 101920 | 53734 | 50449411 |
Dark circles under eyes | 13.49 | 12.75 | 10 | 101969 | 517 | 50502628 |
Gingival swelling | 13.47 | 12.75 | 26 | 101953 | 3769 | 50499376 |
Jaundice cholestatic | 13.46 | 12.75 | 31 | 101948 | 5080 | 50498065 |
Feeling jittery | 13.45 | 12.75 | 3 | 101976 | 11157 | 50491988 |
Lymphangitis | 13.45 | 12.75 | 12 | 101967 | 808 | 50502337 |
Osteomyelitis | 13.40 | 12.75 | 84 | 101895 | 22269 | 50480876 |
Rectal neoplasm | 13.39 | 12.75 | 4 | 101975 | 22 | 50503123 |
Paraneoplastic syndrome | 13.39 | 12.75 | 10 | 101969 | 523 | 50502622 |
Wound dehiscence | 13.37 | 12.75 | 28 | 101951 | 4302 | 50498843 |
Mean cell haemoglobin decreased | 13.33 | 12.75 | 24 | 101955 | 3299 | 50499846 |
Tumour haemorrhage | 13.28 | 12.75 | 15 | 101964 | 1340 | 50501805 |
Kidney infection | 13.21 | 12.75 | 11 | 101968 | 18735 | 50484410 |
Trismus | 13.20 | 12.75 | 24 | 101955 | 3324 | 50499821 |
Head discomfort | 13.20 | 12.75 | 3 | 101976 | 11016 | 50492129 |
Herpes zoster | 13.15 | 12.75 | 86 | 101893 | 70700 | 50432445 |
Urinary incontinence | 13.04 | 12.75 | 23 | 101956 | 28185 | 50474960 |
Radiotherapy | 13.02 | 12.75 | 8 | 101971 | 302 | 50502843 |
Obesity | 12.90 | 12.75 | 9 | 101970 | 16766 | 50486379 |
Subclavian vein thrombosis | 12.90 | 12.75 | 17 | 101962 | 1782 | 50501363 |
Female genital tract fistula | 12.87 | 12.75 | 25 | 101954 | 3641 | 50499504 |
Panic attack | 12.84 | 12.75 | 12 | 101967 | 19330 | 50483815 |
Dizziness | 12.81 | 12.75 | 569 | 101410 | 345800 | 50157345 |
MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
---|---|---|---|---|---|---|
Palmar-plantar erythrodysaesthesia syndrome | 2314.90 | 14.19 | 880 | 47570 | 13879 | 29512198 |
Diarrhoea | 1355.98 | 14.19 | 2138 | 46312 | 330560 | 29195517 |
Disease progression | 1070.21 | 14.19 | 960 | 47490 | 80956 | 29445121 |
Death | 567.75 | 14.19 | 1521 | 46929 | 340563 | 29185514 |
Arteriospasm coronary | 401.44 | 14.19 | 153 | 48297 | 2412 | 29523665 |
Mucosal inflammation | 398.77 | 14.19 | 364 | 48086 | 31231 | 29494846 |
Neuropathy peripheral | 333.74 | 14.19 | 491 | 47959 | 70536 | 29455541 |
Vomiting | 260.10 | 14.19 | 850 | 47600 | 211410 | 29314667 |
Dehydration | 251.79 | 14.19 | 570 | 47880 | 114178 | 29411899 |
Stomatitis | 229.13 | 14.19 | 293 | 48157 | 36820 | 29489257 |
Nausea | 227.39 | 14.19 | 1005 | 47445 | 288250 | 29237827 |
Anastomotic leak | 208.91 | 14.19 | 65 | 48385 | 531 | 29525546 |
Enteritis | 205.79 | 14.19 | 132 | 48318 | 6659 | 29519418 |
Gastrointestinal perforation | 180.78 | 14.19 | 96 | 48354 | 3387 | 29522690 |
Metastases to liver | 172.15 | 14.19 | 148 | 48302 | 11708 | 29514369 |
Neurotoxicity | 168.07 | 14.19 | 160 | 48290 | 14453 | 29511624 |
Malignant neoplasm progression | 167.45 | 14.19 | 372 | 48078 | 73487 | 29452590 |
Intestinal obstruction | 161.61 | 14.19 | 178 | 48272 | 19099 | 29506978 |
Dihydropyrimidine dehydrogenase deficiency | 155.56 | 14.19 | 34 | 48416 | 45 | 29526032 |
Drug ineffective | 147.75 | 14.19 | 230 | 48220 | 362940 | 29163137 |
Metastases to lung | 147.66 | 14.19 | 114 | 48336 | 7741 | 29518336 |
Decreased appetite | 145.39 | 14.19 | 545 | 47905 | 144797 | 29381280 |
Bone marrow failure | 139.23 | 14.19 | 197 | 48253 | 27252 | 29498825 |
Completed suicide | 133.37 | 14.19 | 3 | 48447 | 90243 | 29435834 |
Anastomotic complication | 126.27 | 14.19 | 39 | 48411 | 310 | 29525767 |
Gastrointestinal toxicity | 122.78 | 14.19 | 63 | 48387 | 2068 | 29524009 |
Skin toxicity | 113.50 | 14.19 | 73 | 48377 | 3698 | 29522379 |
Myelosuppression | 109.62 | 14.19 | 117 | 48333 | 12110 | 29513967 |
Abdominal pain | 102.44 | 14.19 | 466 | 47984 | 134891 | 29391186 |
Neutropenia | 102.34 | 14.19 | 457 | 47993 | 131254 | 29394823 |
Ileus | 102.14 | 14.19 | 122 | 48328 | 14280 | 29511797 |
Headache | 90.55 | 14.19 | 91 | 48359 | 173916 | 29352161 |
Enterocolitis | 90.28 | 14.19 | 80 | 48370 | 6586 | 29519491 |
Colon cancer metastatic | 88.57 | 14.19 | 45 | 48405 | 1446 | 29524631 |
Therapy cessation | 84.20 | 14.19 | 111 | 48339 | 14351 | 29511726 |
Pneumonia | 82.78 | 14.19 | 260 | 48190 | 319912 | 29206165 |
Arthralgia | 82.22 | 14.19 | 65 | 48385 | 139552 | 29386525 |
Metastases to peritoneum | 76.36 | 14.19 | 41 | 48409 | 1479 | 29524598 |
Condition aggravated | 73.26 | 14.19 | 79 | 48371 | 146216 | 29379861 |
Carcinoembryonic antigen increased | 72.41 | 14.19 | 30 | 48420 | 594 | 29525483 |
Cardiac failure congestive | 70.71 | 14.19 | 19 | 48431 | 76562 | 29449515 |
Intestinal perforation | 70.06 | 14.19 | 76 | 48374 | 8010 | 29518067 |
Overdose | 69.67 | 14.19 | 22 | 48428 | 79797 | 29446280 |
Gastrointestinal anastomotic leak | 69.20 | 14.19 | 25 | 48425 | 336 | 29525741 |
Tumour perforation | 69.09 | 14.19 | 23 | 48427 | 238 | 29525839 |
Proteus infection | 65.73 | 14.19 | 31 | 48419 | 844 | 29525233 |
Fall | 64.57 | 14.19 | 120 | 48330 | 177058 | 29349019 |
Skin exfoliation | 64.02 | 14.19 | 125 | 48325 | 22520 | 29503557 |
Necrotising fasciitis | 63.59 | 14.19 | 49 | 48401 | 3316 | 29522761 |
Dysphagia | 62.42 | 14.19 | 215 | 48235 | 54711 | 29471366 |
Stomal varices | 62.09 | 14.19 | 15 | 48435 | 39 | 29526038 |
Drug interaction | 59.23 | 14.19 | 149 | 48301 | 197236 | 29328841 |
Cardiotoxicity | 58.47 | 14.19 | 54 | 48396 | 4690 | 29521387 |
Neoplasm progression | 57.88 | 14.19 | 107 | 48343 | 18505 | 29507572 |
Thrombocytopenia | 56.39 | 14.19 | 396 | 48054 | 134427 | 29391650 |
Fingerprint loss | 54.61 | 14.19 | 13 | 48437 | 31 | 29526046 |
Depression | 53.50 | 14.19 | 37 | 48413 | 85110 | 29440967 |
Haematotoxicity | 52.93 | 14.19 | 60 | 48390 | 6639 | 29519438 |
Colitis | 52.12 | 14.19 | 140 | 48310 | 31108 | 29494969 |
Peritonitis | 50.92 | 14.19 | 89 | 48361 | 14735 | 29511342 |
Subileus | 50.60 | 14.19 | 40 | 48410 | 2810 | 29523267 |
Pulmonary embolism | 49.46 | 14.19 | 252 | 48198 | 76282 | 29449795 |
Product dose omission issue | 49.38 | 14.19 | 51 | 48399 | 96332 | 29429745 |
Rectal perforation | 48.88 | 14.19 | 20 | 48430 | 383 | 29525694 |
Anxiety | 48.64 | 14.19 | 41 | 48409 | 85324 | 29440753 |
Wound dehiscence | 48.60 | 14.19 | 40 | 48410 | 2977 | 29523100 |
Induration | 47.88 | 14.19 | 25 | 48425 | 851 | 29525226 |
Paraesthesia | 47.22 | 14.19 | 194 | 48256 | 53651 | 29472426 |
Hiccups | 47.03 | 14.19 | 65 | 48385 | 8788 | 29517289 |
Faecal volume decreased | 46.51 | 14.19 | 14 | 48436 | 101 | 29525976 |
Metastases to lymph nodes | 46.20 | 14.19 | 44 | 48406 | 3973 | 29522104 |
Portal hypertension | 45.54 | 14.19 | 41 | 48409 | 3445 | 29522632 |
Confusional state | 45.32 | 14.19 | 88 | 48362 | 127789 | 29398288 |
Obstruction gastric | 45.20 | 14.19 | 24 | 48426 | 846 | 29525231 |
Dermatitis acneiform | 44.78 | 14.19 | 50 | 48400 | 5441 | 29520636 |
Vascular pain | 44.29 | 14.19 | 14 | 48436 | 121 | 29525956 |
Gastric perforation | 43.88 | 14.19 | 33 | 48417 | 2153 | 29523924 |
Proteinuria | 43.17 | 14.19 | 86 | 48364 | 15718 | 29510359 |
No adverse event | 42.90 | 14.19 | 91 | 48359 | 17387 | 29508690 |
Non-cirrhotic portal hypertension | 42.69 | 14.19 | 16 | 48434 | 240 | 29525837 |
Toxic leukoencephalopathy | 41.24 | 14.19 | 16 | 48434 | 265 | 29525812 |
Cough | 40.87 | 14.19 | 92 | 48358 | 126635 | 29399442 |
Prothrombin level decreased | 40.81 | 14.19 | 24 | 48426 | 1034 | 29525043 |
Device occlusion | 40.57 | 14.19 | 48 | 48402 | 5560 | 29520517 |
Pancreatic neuroendocrine tumour metastatic | 40.42 | 14.19 | 12 | 48438 | 82 | 29525995 |
Recall phenomenon | 40.33 | 14.19 | 19 | 48431 | 516 | 29525561 |
Diaphragmatic spasm | 39.81 | 14.19 | 12 | 48438 | 87 | 29525990 |
Intentional product misuse | 39.66 | 14.19 | 5 | 48445 | 34656 | 29491421 |
Hallucination | 39.58 | 14.19 | 12 | 48438 | 44700 | 29481377 |
Portal shunt | 39.40 | 14.19 | 10 | 48440 | 34 | 29526043 |
Aggression | 38.62 | 14.19 | 6 | 48444 | 35535 | 29490542 |
Metastatic gastric cancer | 38.59 | 14.19 | 13 | 48437 | 140 | 29525937 |
Small intestinal obstruction | 38.01 | 14.19 | 73 | 48377 | 12988 | 29513089 |
Splenorenal shunt | 37.80 | 14.19 | 8 | 48442 | 8 | 29526069 |
Large intestine perforation | 37.57 | 14.19 | 53 | 48397 | 7303 | 29518774 |
Clostridial infection | 37.53 | 14.19 | 36 | 48414 | 3279 | 29522798 |
Influenza | 37.51 | 14.19 | 11 | 48439 | 41870 | 29484207 |
Mucosal disorder | 37.49 | 14.19 | 26 | 48424 | 1494 | 29524583 |
Metastases to central nervous system | 37.34 | 14.19 | 52 | 48398 | 7079 | 29518998 |
Hepatic lesion | 37.17 | 14.19 | 35 | 48415 | 3115 | 29522962 |
Anal erythema | 36.70 | 14.19 | 11 | 48439 | 78 | 29525999 |
Laryngospasm | 36.43 | 14.19 | 24 | 48426 | 1266 | 29524811 |
Oesophageal haemorrhage | 36.38 | 14.19 | 23 | 48427 | 1130 | 29524947 |
Foetal exposure during pregnancy | 36.16 | 14.19 | 6 | 48444 | 33861 | 29492216 |
Weight increased | 35.52 | 14.19 | 44 | 48406 | 76623 | 29449454 |
Hyperammonaemic encephalopathy | 35.48 | 14.19 | 28 | 48422 | 1962 | 29524115 |
Agitation | 35.38 | 14.19 | 20 | 48430 | 51284 | 29474793 |
Large intestinal obstruction | 35.38 | 14.19 | 24 | 48426 | 1330 | 29524747 |
Focal nodular hyperplasia | 34.52 | 14.19 | 12 | 48438 | 143 | 29525934 |
Hypokalaemia | 34.32 | 14.19 | 168 | 48282 | 50035 | 29476042 |
Terminal ileitis | 33.83 | 14.19 | 11 | 48439 | 105 | 29525972 |
Rhabdomyolysis | 33.66 | 14.19 | 30 | 48420 | 60778 | 29465299 |
Neutropenic sepsis | 33.46 | 14.19 | 65 | 48385 | 11662 | 29514415 |
Insomnia | 33.27 | 14.19 | 59 | 48391 | 88702 | 29437375 |
Musculoskeletal stiffness | 33.25 | 14.19 | 10 | 48440 | 37448 | 29488629 |
Suicidal ideation | 33.21 | 14.19 | 8 | 48442 | 34708 | 29491369 |
Dizziness | 33.19 | 14.19 | 179 | 48271 | 189505 | 29336572 |
Intestinal dilatation | 33.09 | 14.19 | 21 | 48429 | 1039 | 29525038 |
Protein urine | 33.08 | 14.19 | 19 | 48431 | 783 | 29525294 |
Skin discolouration | 33.04 | 14.19 | 76 | 48374 | 15333 | 29510744 |
Ascites | 32.94 | 14.19 | 133 | 48317 | 36486 | 29489591 |
Metastasis | 32.84 | 14.19 | 34 | 48416 | 3395 | 29522682 |
Anal prolapse | 32.50 | 14.19 | 6 | 48444 | 0 | 29526077 |
Stoma site haemorrhage | 32.31 | 14.19 | 18 | 48432 | 699 | 29525378 |
Dysaesthesia pharynx | 31.75 | 14.19 | 9 | 48441 | 51 | 29526026 |
Oesophagitis | 31.51 | 14.19 | 64 | 48386 | 11859 | 29514218 |
Electrocardiogram QT prolonged | 31.44 | 14.19 | 10 | 48440 | 36127 | 29489950 |
Hypovolaemic shock | 31.38 | 14.19 | 44 | 48406 | 6028 | 29520049 |
Tumour marker increased | 31.10 | 14.19 | 16 | 48434 | 528 | 29525549 |
Peripheral ischaemia | 30.89 | 14.19 | 40 | 48410 | 5079 | 29520998 |
Colon cancer recurrent | 30.80 | 14.19 | 10 | 48440 | 95 | 29525982 |
Skin fissures | 30.79 | 14.19 | 35 | 48415 | 3884 | 29522193 |
Ventricular fibrillation | 30.60 | 14.19 | 75 | 48375 | 15758 | 29510319 |
Joint swelling | 30.58 | 14.19 | 22 | 48428 | 49608 | 29476469 |
Bradycardia | 30.04 | 14.19 | 38 | 48412 | 65591 | 29460486 |
Pruritus | 29.96 | 14.19 | 95 | 48355 | 116754 | 29409323 |
Hospice care | 29.65 | 14.19 | 39 | 48411 | 5029 | 29521048 |
Polyneuropathy | 29.50 | 14.19 | 63 | 48387 | 12089 | 29513988 |
Biliary obstruction | 28.83 | 14.19 | 27 | 48423 | 2387 | 29523690 |
Therapy interrupted | 28.34 | 14.19 | 50 | 48400 | 8336 | 29517741 |
Hyperbilirubinaemia | 28.07 | 14.19 | 70 | 48380 | 14864 | 29511213 |
COVID-19 | 27.91 | 14.19 | 12 | 48438 | 36002 | 29490075 |
Psoriasis | 27.89 | 14.19 | 9 | 48441 | 32218 | 29493859 |
Gastric dilatation | 27.76 | 14.19 | 15 | 48435 | 548 | 29525529 |
Asthenia | 27.45 | 14.19 | 500 | 47950 | 214750 | 29311327 |
Arterial thrombosis | 27.43 | 14.19 | 21 | 48429 | 1407 | 29524670 |
Tenderness | 27.40 | 14.19 | 40 | 48410 | 5687 | 29520390 |
Sinusitis | 27.34 | 14.19 | 11 | 48439 | 34339 | 29491738 |
Abnormal behaviour | 27.29 | 14.19 | 3 | 48447 | 23124 | 29502953 |
Gastrointestinal stoma necrosis | 27.08 | 14.19 | 5 | 48445 | 0 | 29526077 |
Disseminated intravascular coagulation | 26.99 | 14.19 | 83 | 48367 | 19897 | 29506180 |
Proctalgia | 26.92 | 14.19 | 34 | 48416 | 4211 | 29521866 |
Gastroenteritis radiation | 26.61 | 14.19 | 12 | 48438 | 294 | 29525783 |
Erythema | 26.42 | 14.19 | 213 | 48237 | 75393 | 29450684 |
Pelvic abscess | 26.15 | 14.19 | 17 | 48433 | 877 | 29525200 |
Rectal tenesmus | 25.58 | 14.19 | 15 | 48435 | 643 | 29525434 |
Feeling abnormal | 25.47 | 14.19 | 31 | 48419 | 54414 | 29471663 |
Product use issue | 25.46 | 14.19 | 28 | 48422 | 51416 | 29474661 |
Chronic obstructive pulmonary disease | 25.44 | 14.19 | 18 | 48432 | 40937 | 29485140 |
Asthma | 25.11 | 14.19 | 12 | 48438 | 33837 | 29492240 |
Injection site pain | 24.84 | 14.19 | 11 | 48439 | 32435 | 29493642 |
Gastrointestinal disorder | 24.81 | 14.19 | 103 | 48347 | 28603 | 29497474 |
Pigmentation disorder | 24.72 | 14.19 | 23 | 48427 | 2016 | 29524061 |
Dyspnoea | 24.65 | 14.19 | 382 | 48068 | 326350 | 29199727 |
Rectal cancer metastatic | 24.42 | 14.19 | 10 | 48440 | 192 | 29525885 |
Fatigue | 24.38 | 14.19 | 685 | 47765 | 316136 | 29209941 |
Gastrointestinal stoma complication | 24.21 | 14.19 | 18 | 48432 | 1154 | 29524923 |
Hyperfibrinolysis | 23.96 | 14.19 | 6 | 48444 | 19 | 29526058 |
Performance status decreased | 23.87 | 14.19 | 30 | 48420 | 3697 | 29522380 |
Myalgia | 23.62 | 14.19 | 54 | 48396 | 73965 | 29452112 |
Pancreatitis viral | 23.62 | 14.19 | 5 | 48445 | 5 | 29526072 |
Colostomy | 23.41 | 14.19 | 12 | 48438 | 393 | 29525684 |
Bronchitis | 23.17 | 14.19 | 16 | 48434 | 36852 | 29489225 |
Cholangitis | 23.01 | 14.19 | 43 | 48407 | 7494 | 29518583 |
Seizure | 22.97 | 14.19 | 77 | 48373 | 93046 | 29433031 |
Temperature intolerance | 22.80 | 14.19 | 26 | 48424 | 2895 | 29523182 |
Cellulitis | 22.63 | 14.19 | 25 | 48425 | 45815 | 29480262 |
Palmar erythema | 22.48 | 14.19 | 10 | 48440 | 237 | 29525840 |
Colorectal cancer metastatic | 22.36 | 14.19 | 13 | 48437 | 548 | 29525529 |
Inappropriate schedule of product administration | 22.23 | 14.19 | 24 | 48426 | 44448 | 29481629 |
Drug reaction with eosinophilia and systemic symptoms | 22.22 | 14.19 | 9 | 48441 | 27983 | 29498094 |
Leukoencephalopathy | 22.05 | 14.19 | 29 | 48421 | 3738 | 29522339 |
Nasopharyngitis | 22.04 | 14.19 | 40 | 48410 | 59625 | 29466452 |
Therapy change | 21.77 | 14.19 | 24 | 48426 | 2574 | 29523503 |
Nephrotic syndrome | 21.74 | 14.19 | 38 | 48412 | 6290 | 29519787 |
Hypoaesthesia | 21.68 | 14.19 | 156 | 48294 | 53311 | 29472766 |
Swelling of eyelid | 21.67 | 14.19 | 13 | 48437 | 581 | 29525496 |
Arthritis | 21.63 | 14.19 | 7 | 48443 | 25012 | 29501065 |
Wheezing | 21.46 | 14.19 | 14 | 48436 | 33226 | 29492851 |
Irritability | 21.39 | 14.19 | 5 | 48445 | 22147 | 29503930 |
Chronic kidney disease | 21.34 | 14.19 | 17 | 48433 | 36399 | 29489678 |
Therapeutic product effect decreased | 21.00 | 14.19 | 11 | 48439 | 29440 | 29496637 |
Drug hypersensitivity | 20.95 | 14.19 | 51 | 48399 | 68355 | 29457722 |
Nasal congestion | 20.94 | 14.19 | 3 | 48447 | 18876 | 29507201 |
Hepatic infarction | 20.89 | 14.19 | 9 | 48441 | 197 | 29525880 |
Urticaria | 20.77 | 14.19 | 36 | 48414 | 54624 | 29471453 |
Rash maculo-papular | 20.64 | 14.19 | 7 | 48443 | 24282 | 29501795 |
Neutrophil count decreased | 20.58 | 14.19 | 132 | 48318 | 43435 | 29482642 |
Treatment noncompliance | 20.55 | 14.19 | 7 | 48443 | 24220 | 29501857 |
Lactic acidosis | 20.55 | 14.19 | 12 | 48438 | 30235 | 29495842 |
Failure to anastomose | 20.52 | 14.19 | 9 | 48441 | 206 | 29525871 |
Incisional hernia | 20.41 | 14.19 | 16 | 48434 | 1110 | 29524967 |
Blood pressure fluctuation | 20.21 | 14.19 | 4 | 48446 | 19890 | 29506187 |
Delirium | 19.98 | 14.19 | 21 | 48429 | 39376 | 29486701 |
Metastases to the mediastinum | 19.98 | 14.19 | 9 | 48441 | 220 | 29525857 |
Change of bowel habit | 19.94 | 14.19 | 15 | 48435 | 979 | 29525098 |
Balance disorder | 19.83 | 14.19 | 18 | 48432 | 36152 | 29489925 |
Cataract | 19.81 | 14.19 | 6 | 48444 | 22372 | 29503705 |
Somnolence | 19.71 | 14.19 | 83 | 48367 | 93872 | 29432205 |
Erectile dysfunction | 19.65 | 14.19 | 3 | 48447 | 18006 | 29508071 |
Pharyngeal ulceration | 19.63 | 14.19 | 10 | 48440 | 323 | 29525754 |
Cognitive disorder | 19.57 | 14.19 | 7 | 48443 | 23492 | 29502585 |
Therapeutic product effect prolonged | 19.54 | 14.19 | 9 | 48441 | 232 | 29525845 |
Eosinophilia | 19.51 | 14.19 | 6 | 48444 | 22155 | 29503922 |
Alanine aminotransferase increased | 19.37 | 14.19 | 56 | 48394 | 70888 | 29455189 |
Gastrointestinal mucosal necrosis | 19.23 | 14.19 | 8 | 48442 | 160 | 29525917 |
Gastrointestinal mucosal disorder | 19.19 | 14.19 | 10 | 48440 | 339 | 29525738 |
Nail bed inflammation | 19.14 | 14.19 | 8 | 48442 | 162 | 29525915 |
Gastrointestinal injury | 19.06 | 14.19 | 10 | 48440 | 344 | 29525733 |
Prostate cancer | 19.01 | 14.19 | 9 | 48441 | 25518 | 29500559 |
Hepatic atrophy | 18.96 | 14.19 | 8 | 48442 | 166 | 29525911 |
Scrotal ulcer | 18.87 | 14.19 | 10 | 48440 | 351 | 29525726 |
Coronary artery disease | 18.79 | 14.19 | 27 | 48423 | 44163 | 29481914 |
Haematemesis | 18.71 | 14.19 | 85 | 48365 | 24541 | 29501536 |
Tremor | 18.69 | 14.19 | 60 | 48390 | 73478 | 29452599 |
Arthropathy | 18.69 | 14.19 | 6 | 48444 | 21548 | 29504529 |
Alopecia | 18.52 | 14.19 | 71 | 48379 | 19013 | 29507064 |
Metastases to pelvis | 18.40 | 14.19 | 9 | 48441 | 266 | 29525811 |
Pulmonary hypertension | 18.37 | 14.19 | 4 | 48446 | 18604 | 29507473 |
Peripheral sensory neuropathy | 18.28 | 14.19 | 34 | 48416 | 5905 | 29520172 |
Electrocardiogram ST segment elevation | 18.13 | 14.19 | 29 | 48421 | 4463 | 29521614 |
Basal cell carcinoma | 18.04 | 14.19 | 3 | 48447 | 16907 | 29509170 |
Anterior spinal artery syndrome | 18.01 | 14.19 | 4 | 48446 | 6 | 29526071 |
Wrong technique in product usage process | 18.00 | 14.19 | 15 | 48435 | 31413 | 29494664 |
Leukopenia | 17.92 | 14.19 | 153 | 48297 | 55050 | 29471027 |
Intestinal ischaemia | 17.77 | 14.19 | 36 | 48414 | 6656 | 29519421 |
Peripheral embolism | 17.75 | 14.19 | 14 | 48436 | 980 | 29525097 |
Aortic thrombosis | 17.62 | 14.19 | 12 | 48438 | 669 | 29525408 |
Periportal sinus dilatation | 17.54 | 14.19 | 5 | 48445 | 29 | 29526048 |
Product prescribing error | 17.47 | 14.19 | 4 | 48446 | 17972 | 29508105 |
Ectropion | 17.45 | 14.19 | 6 | 48444 | 69 | 29526008 |
Metastases to meninges | 17.40 | 14.19 | 15 | 48435 | 1190 | 29524887 |
Dry skin | 17.37 | 14.19 | 80 | 48370 | 23227 | 29502850 |
Gastrointestinal inflammation | 17.37 | 14.19 | 23 | 48427 | 2985 | 29523092 |
Idiosyncratic drug reaction | 17.32 | 14.19 | 10 | 48440 | 416 | 29525661 |
Dysaesthesia | 17.29 | 14.19 | 19 | 48431 | 2031 | 29524046 |
Hypertriglyceridaemia | 17.28 | 14.19 | 38 | 48412 | 7437 | 29518640 |
Feeling cold | 17.19 | 14.19 | 43 | 48407 | 9148 | 29516929 |
Vasospasm | 17.01 | 14.19 | 9 | 48441 | 315 | 29525762 |
Upper respiratory tract infection | 17.01 | 14.19 | 12 | 48438 | 27337 | 29498740 |
Weight decreased | 16.96 | 14.19 | 344 | 48106 | 150561 | 29375516 |
Metastases to eye | 16.93 | 14.19 | 6 | 48444 | 76 | 29526001 |
Faeces pale | 16.83 | 14.19 | 15 | 48435 | 1244 | 29524833 |
General physical health deterioration | 16.80 | 14.19 | 249 | 48201 | 102608 | 29423469 |
Heart rate decreased | 16.76 | 14.19 | 10 | 48440 | 24902 | 29501175 |
Oxygen saturation decreased | 16.71 | 14.19 | 30 | 48420 | 44907 | 29481170 |
Neutrophilia | 16.66 | 14.19 | 25 | 48425 | 3641 | 29522436 |
Blood glucose increased | 16.51 | 14.19 | 46 | 48404 | 58938 | 29467139 |
Mobility decreased | 16.45 | 14.19 | 11 | 48439 | 25769 | 29500308 |
Urethral ulcer | 16.25 | 14.19 | 3 | 48447 | 0 | 29526077 |
Ileus paralytic | 16.20 | 14.19 | 30 | 48420 | 5193 | 29520884 |
Metastatic neoplasm | 16.19 | 14.19 | 21 | 48429 | 2671 | 29523406 |
Phrenic nerve paralysis | 15.95 | 14.19 | 6 | 48444 | 91 | 29525986 |
Biliary fistula | 15.94 | 14.19 | 5 | 48445 | 42 | 29526035 |
Scleroderma-like reaction | 15.74 | 14.19 | 5 | 48445 | 44 | 29526033 |
Malignant ascites | 15.73 | 14.19 | 9 | 48441 | 368 | 29525709 |
Liver injury | 15.57 | 14.19 | 51 | 48399 | 12639 | 29513438 |
Cryptitis | 15.54 | 14.19 | 5 | 48445 | 46 | 29526031 |
Genital erythema | 15.54 | 14.19 | 7 | 48443 | 171 | 29525906 |
Prostatic calcification | 15.54 | 14.19 | 6 | 48444 | 98 | 29525979 |
Muscular weakness | 15.50 | 14.19 | 51 | 48399 | 62001 | 29464076 |
Rosacea | 15.49 | 14.19 | 13 | 48437 | 994 | 29525083 |
Cardiac failure | 15.44 | 14.19 | 72 | 48378 | 79215 | 29446862 |
Psychotic disorder | 15.43 | 14.19 | 7 | 48443 | 20347 | 29505730 |
Ileal ulcer | 15.36 | 14.19 | 10 | 48440 | 517 | 29525560 |
Depressed mood | 15.32 | 14.19 | 4 | 48446 | 16444 | 29509633 |
Acute kidney injury | 15.27 | 14.19 | 325 | 48125 | 264942 | 29261135 |
Pelvic fluid collection | 15.27 | 14.19 | 6 | 48444 | 103 | 29525974 |
Interstitial lung disease | 15.22 | 14.19 | 153 | 48297 | 57565 | 29468512 |
Liver function test abnormal | 15.14 | 14.19 | 15 | 48435 | 28903 | 29497174 |
Subacute cutaneous lupus erythematosus | 15.13 | 14.19 | 12 | 48438 | 847 | 29525230 |
Varices oesophageal | 15.09 | 14.19 | 22 | 48428 | 3124 | 29522953 |
Acral peeling skin syndrome | 15.08 | 14.19 | 5 | 48445 | 51 | 29526026 |
Hot flush | 15.08 | 14.19 | 3 | 48447 | 14867 | 29511210 |
Pneumatosis intestinalis | 14.96 | 14.19 | 22 | 48428 | 3147 | 29522930 |
Perforation | 14.93 | 14.19 | 7 | 48443 | 188 | 29525889 |
Perineal ulceration | 14.87 | 14.19 | 4 | 48446 | 18 | 29526059 |
Influenza like illness | 14.87 | 14.19 | 11 | 48439 | 24459 | 29501618 |
Hypoglycaemia | 14.84 | 14.19 | 36 | 48414 | 48310 | 29477767 |
Memory impairment | 14.80 | 14.19 | 23 | 48427 | 36447 | 29489630 |
Pallor | 14.77 | 14.19 | 8 | 48442 | 21016 | 29505061 |
Hypotension | 14.68 | 14.19 | 227 | 48223 | 194127 | 29331950 |
Electromyogram abnormal | 14.66 | 14.19 | 5 | 48445 | 56 | 29526021 |
Acute coronary syndrome | 14.64 | 14.19 | 49 | 48401 | 12276 | 29513801 |
Prothrombin time ratio increased | 14.61 | 14.19 | 6 | 48444 | 116 | 29525961 |
Metastases to adrenals | 14.46 | 14.19 | 12 | 48438 | 903 | 29525174 |
Contusion | 14.23 | 14.19 | 18 | 48432 | 31077 | 29495000 |
Wound complication | 14.21 | 14.19 | 17 | 48433 | 1992 | 29524085 |
MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
---|---|---|---|---|---|---|
Palmar-plantar erythrodysaesthesia syndrome | 7023.15 | 12.64 | 2422 | 110811 | 26397 | 64359102 |
Diarrhoea | 2639.72 | 12.64 | 4597 | 108636 | 718107 | 63667392 |
Disease progression | 2633.21 | 12.64 | 2095 | 111138 | 139585 | 64245914 |
Mucosal inflammation | 1075.98 | 12.64 | 886 | 112347 | 61698 | 64323801 |
Malignant neoplasm progression | 1042.75 | 12.64 | 1132 | 112101 | 111739 | 64273760 |
Metastases to liver | 912.67 | 12.64 | 552 | 112681 | 23389 | 64362110 |
Neuropathy peripheral | 760.62 | 12.64 | 983 | 112250 | 116542 | 64268957 |
Metastases to bone | 707.10 | 12.64 | 443 | 112790 | 19992 | 64365507 |
Death | 566.41 | 12.64 | 1995 | 111238 | 480710 | 63904789 |
Metastases to lung | 566.36 | 12.64 | 346 | 112887 | 14918 | 64370581 |
Arteriospasm coronary | 561.91 | 12.64 | 246 | 112987 | 5219 | 64380280 |
Vomiting | 516.44 | 12.64 | 2120 | 111113 | 548997 | 63836502 |
Stomatitis | 472.31 | 12.64 | 756 | 112477 | 108849 | 64276650 |
Nausea | 411.68 | 12.64 | 2565 | 110668 | 783235 | 63602264 |
Metastases to central nervous system | 401.06 | 12.64 | 269 | 112964 | 13643 | 64371856 |
Dehydration | 396.18 | 12.64 | 1048 | 112185 | 215715 | 64169784 |
Bone marrow failure | 387.41 | 12.64 | 449 | 112784 | 47503 | 64337996 |
Neurotoxicity | 383.17 | 12.64 | 345 | 112888 | 27059 | 64358440 |
Completed suicide | 377.02 | 12.64 | 3 | 113230 | 224411 | 64161088 |
Neutropenia | 362.78 | 12.64 | 1082 | 112151 | 238542 | 64146957 |
Breast cancer metastatic | 357.61 | 12.64 | 197 | 113036 | 6972 | 64378527 |
Gastrointestinal toxicity | 350.17 | 12.64 | 176 | 113057 | 5146 | 64380353 |
Drug ineffective | 345.19 | 12.64 | 593 | 112640 | 839654 | 63545845 |
Metastases to lymph nodes | 324.37 | 12.64 | 198 | 113035 | 8519 | 64376980 |
Myelosuppression | 309.72 | 12.64 | 288 | 112945 | 23542 | 64361957 |
Enteritis | 306.74 | 12.64 | 216 | 113017 | 11861 | 64373638 |
Skin toxicity | 279.59 | 12.64 | 163 | 113070 | 6439 | 64379060 |
Rheumatoid arthritis | 272.10 | 12.64 | 3 | 113230 | 164291 | 64221208 |
Decreased appetite | 257.34 | 12.64 | 1076 | 112157 | 280213 | 64105286 |
Dihydropyrimidine dehydrogenase deficiency | 246.90 | 12.64 | 55 | 113178 | 75 | 64385424 |
Skin exfoliation | 242.08 | 12.64 | 344 | 112889 | 44541 | 64340958 |
Arthralgia | 232.07 | 12.64 | 261 | 112972 | 441999 | 63943500 |
Neoplasm progression | 228.40 | 12.64 | 319 | 112914 | 40645 | 64344854 |
Condition aggravated | 222.63 | 12.64 | 196 | 113037 | 372230 | 64013269 |
Skin fissures | 217.91 | 12.64 | 165 | 113068 | 10141 | 64375358 |
Thrombocytopenia | 213.11 | 12.64 | 867 | 112366 | 222934 | 64162565 |
Cardiotoxicity | 207.37 | 12.64 | 160 | 113073 | 10114 | 64375385 |
Gastrointestinal perforation | 198.73 | 12.64 | 122 | 113111 | 5302 | 64380197 |
Joint swelling | 195.61 | 12.64 | 67 | 113166 | 215315 | 64170184 |
Metastases to skin | 177.83 | 12.64 | 74 | 113159 | 1378 | 64384121 |
Anastomotic leak | 177.37 | 12.64 | 66 | 113167 | 900 | 64384599 |
Fall | 177.02 | 12.64 | 287 | 112946 | 416539 | 63968960 |
Haematotoxicity | 167.82 | 12.64 | 156 | 113077 | 12740 | 64372759 |
Laryngospasm | 167.24 | 12.64 | 93 | 113140 | 3352 | 64382147 |
Skin discolouration | 161.06 | 12.64 | 250 | 112983 | 35005 | 64350494 |
Dry skin | 160.35 | 12.64 | 307 | 112926 | 50854 | 64334645 |
Drug interaction | 157.76 | 12.64 | 245 | 112988 | 361838 | 64023661 |
Therapy cessation | 156.33 | 12.64 | 236 | 112997 | 32253 | 64353246 |
Tumour marker increased | 153.59 | 12.64 | 88 | 113145 | 3362 | 64382137 |
Paronychia | 146.30 | 12.64 | 108 | 113125 | 6384 | 64379115 |
Asthenia | 141.76 | 12.64 | 1256 | 111977 | 426788 | 63958711 |
Osteonecrosis of jaw | 141.16 | 12.64 | 252 | 112981 | 39573 | 64345926 |
Intestinal obstruction | 140.85 | 12.64 | 239 | 112994 | 36047 | 64349452 |
Overdose | 140.79 | 12.64 | 52 | 113181 | 159514 | 64225985 |
Pseudocirrhosis | 136.75 | 12.64 | 49 | 113184 | 596 | 64384903 |
Enterocolitis | 136.73 | 12.64 | 135 | 113098 | 11883 | 64373616 |
Paraesthesia | 133.35 | 12.64 | 528 | 112705 | 133994 | 64251505 |
Pneumonia | 131.26 | 12.64 | 522 | 112711 | 559054 | 63826445 |
Metastases to peritoneum | 130.50 | 12.64 | 80 | 113153 | 3467 | 64382032 |
Contraindicated product administered | 126.75 | 12.64 | 19 | 113214 | 107810 | 64277689 |
Drug hypersensitivity | 124.87 | 12.64 | 140 | 113093 | 237675 | 64147824 |
Arthropathy | 123.80 | 12.64 | 30 | 113203 | 120937 | 64264562 |
Therapeutic product effect decreased | 119.24 | 12.64 | 28 | 113205 | 115323 | 64270176 |
Sinusitis | 118.30 | 12.64 | 54 | 113179 | 145874 | 64239625 |
Weight increased | 118.25 | 12.64 | 120 | 113113 | 213228 | 64172271 |
Hospice care | 116.53 | 12.64 | 101 | 113132 | 7524 | 64377975 |
Intentional overdose | 115.07 | 12.64 | 12 | 113221 | 89932 | 64295567 |
Non-cirrhotic portal hypertension | 114.84 | 12.64 | 38 | 113195 | 357 | 64385142 |
Carcinoembryonic antigen increased | 114.65 | 12.64 | 59 | 113174 | 1814 | 64383685 |
Musculoskeletal stiffness | 114.11 | 12.64 | 37 | 113196 | 123169 | 64262330 |
Maternal exposure during pregnancy | 112.46 | 12.64 | 17 | 113216 | 95867 | 64289632 |
Headache | 112.37 | 12.64 | 513 | 112720 | 528954 | 63856545 |
Anastomotic complication | 110.30 | 12.64 | 37 | 113196 | 364 | 64385135 |
Cardiac failure congestive | 109.51 | 12.64 | 46 | 113187 | 130534 | 64254965 |
Systemic lupus erythematosus | 108.55 | 12.64 | 7 | 113226 | 77605 | 64307894 |
Metastasis | 106.95 | 12.64 | 85 | 113148 | 5610 | 64379889 |
Nail disorder | 105.85 | 12.64 | 101 | 113132 | 8523 | 64376976 |
Depression | 105.13 | 12.64 | 100 | 113133 | 183191 | 64202308 |
Hepatic lesion | 103.16 | 12.64 | 84 | 113149 | 5740 | 64379759 |
Portal hypertension | 102.44 | 12.64 | 86 | 113147 | 6133 | 64379366 |
Product use issue | 101.65 | 12.64 | 71 | 113162 | 151644 | 64233855 |
Breast cancer | 98.91 | 12.64 | 181 | 113052 | 28967 | 64356532 |
Abdominal pain | 98.82 | 12.64 | 908 | 112325 | 311467 | 64074032 |
Treatment failure | 98.20 | 12.64 | 41 | 113192 | 116775 | 64268724 |
Colitis | 97.20 | 12.64 | 274 | 112959 | 58400 | 64327099 |
Breast cancer recurrent | 96.93 | 12.64 | 59 | 113174 | 2524 | 64382975 |
PIK3CA-activated mutation | 96.87 | 12.64 | 36 | 113197 | 489 | 64385010 |
Lymphangiosis carcinomatosa | 96.24 | 12.64 | 52 | 113181 | 1769 | 64383730 |
Exposure during pregnancy | 95.27 | 12.64 | 12 | 113221 | 77663 | 64307836 |
Fingerprint loss | 93.87 | 12.64 | 22 | 113211 | 43 | 64385456 |
Influenza | 93.47 | 12.64 | 35 | 113198 | 106496 | 64279003 |
Ileus | 91.42 | 12.64 | 153 | 113080 | 22813 | 64362686 |
Psoriasis | 90.61 | 12.64 | 10 | 113223 | 71693 | 64313806 |
Dysaesthesia pharynx | 89.81 | 12.64 | 27 | 113206 | 179 | 64385320 |
Suicide attempt | 89.49 | 12.64 | 10 | 113223 | 70997 | 64314502 |
Bradycardia | 86.49 | 12.64 | 50 | 113183 | 118169 | 64267330 |
Ascites | 84.25 | 12.64 | 270 | 112963 | 61731 | 64323768 |
Polyneuropathy | 82.50 | 12.64 | 135 | 113098 | 19759 | 64365740 |
Carbohydrate antigen 15-3 increased | 81.08 | 12.64 | 38 | 113195 | 949 | 64384550 |
Hyperbilirubinaemia | 80.08 | 12.64 | 138 | 113095 | 21067 | 64364432 |
Metastases to pleura | 77.90 | 12.64 | 40 | 113193 | 1224 | 64384275 |
Onycholysis | 76.49 | 12.64 | 43 | 113190 | 1583 | 64383916 |
Arthritis | 76.14 | 12.64 | 26 | 113207 | 83788 | 64301711 |
Intentional product misuse | 75.80 | 12.64 | 17 | 113216 | 72278 | 64313221 |
Injection site pain | 73.47 | 12.64 | 53 | 113180 | 111355 | 64274144 |
Tumour perforation | 72.50 | 12.64 | 26 | 113207 | 317 | 64385182 |
Metastatic neoplasm | 72.29 | 12.64 | 61 | 113172 | 4381 | 64381118 |
Metastases to spine | 71.91 | 12.64 | 56 | 113177 | 3587 | 64381912 |
Pruritus | 71.42 | 12.64 | 294 | 112939 | 312106 | 64073393 |
Hypokalaemia | 71.39 | 12.64 | 411 | 112822 | 121492 | 64264007 |
Bronchitis | 71.37 | 12.64 | 52 | 113181 | 108691 | 64276808 |
Suicidal ideation | 71.08 | 12.64 | 15 | 113218 | 66527 | 64318972 |
Infusion site coldness | 70.68 | 12.64 | 23 | 113210 | 204 | 64385295 |
Chronic obstructive pulmonary disease | 70.03 | 12.64 | 19 | 113214 | 71029 | 64314470 |
Hypotension | 69.36 | 12.64 | 389 | 112844 | 380585 | 64004914 |
Rhabdomyolysis | 68.23 | 12.64 | 38 | 113195 | 91688 | 64293811 |
Plasma cell myeloma | 68.03 | 12.64 | 3 | 113230 | 46072 | 64339427 |
Pulmonary embolism | 67.97 | 12.64 | 465 | 112768 | 145891 | 64239608 |
Bone lesion | 66.56 | 12.64 | 62 | 113171 | 5075 | 64380424 |
Anxiety | 64.93 | 12.64 | 164 | 113069 | 202485 | 64183014 |
Urticaria | 63.72 | 12.64 | 100 | 113133 | 147217 | 64238282 |
Intestinal perforation | 63.61 | 12.64 | 104 | 113129 | 15209 | 64370290 |
Electrocardiogram QT prolonged | 63.43 | 12.64 | 30 | 113203 | 79418 | 64306081 |
Osteoarthritis | 62.30 | 12.64 | 17 | 113216 | 63319 | 64322180 |
Confusional state | 62.05 | 12.64 | 242 | 112991 | 260902 | 64124597 |
Product dose omission issue | 61.31 | 12.64 | 159 | 113074 | 194588 | 64190911 |
Leukopenia | 61.01 | 12.64 | 344 | 112889 | 100898 | 64284601 |
Stomal varices | 60.78 | 12.64 | 15 | 113218 | 40 | 64385459 |
Glossodynia | 60.65 | 12.64 | 19 | 113214 | 64677 | 64320822 |
Gamma-glutamyltransferase decreased | 60.30 | 12.64 | 23 | 113210 | 337 | 64385162 |
Hypovolaemic shock | 60.28 | 12.64 | 82 | 113151 | 10184 | 64375315 |
Fatigue | 59.90 | 12.64 | 1728 | 111505 | 747002 | 63638497 |
Colon cancer metastatic | 59.81 | 12.64 | 39 | 113194 | 1884 | 64383615 |
Insomnia | 59.66 | 12.64 | 165 | 113068 | 197671 | 64187828 |
Recall phenomenon | 59.59 | 12.64 | 31 | 113202 | 975 | 64384524 |
Nail discolouration | 59.53 | 12.64 | 43 | 113190 | 2457 | 64383042 |
Feeling abnormal | 59.40 | 12.64 | 89 | 113144 | 133513 | 64251986 |
Hypoaesthesia | 59.35 | 12.64 | 433 | 112800 | 138675 | 64246824 |
Asthma | 59.34 | 12.64 | 48 | 113185 | 95177 | 64290322 |
Osteonecrosis | 59.20 | 12.64 | 144 | 113089 | 28085 | 64357414 |
Ejection fraction decreased | 58.67 | 12.64 | 145 | 113088 | 28562 | 64356937 |
Acute kidney injury | 57.13 | 12.64 | 509 | 112724 | 448731 | 63936768 |
Blood pressure fluctuation | 56.84 | 12.64 | 11 | 113222 | 51860 | 64333639 |
Proteinuria | 56.63 | 12.64 | 140 | 113093 | 27583 | 64357916 |
Drug reaction with eosinophilia and systemic symptoms | 56.33 | 12.64 | 13 | 113220 | 54204 | 64331295 |
Agitation | 55.75 | 12.64 | 44 | 113189 | 88323 | 64297176 |
Dysaesthesia | 54.76 | 12.64 | 55 | 113178 | 4940 | 64380559 |
Gastrointestinal anastomotic leak | 53.86 | 12.64 | 22 | 113211 | 390 | 64385109 |
Mobility decreased | 53.83 | 12.64 | 43 | 113190 | 85797 | 64299702 |
Nasal congestion | 53.33 | 12.64 | 19 | 113214 | 59639 | 64325860 |
Hepatic function abnormal | 53.20 | 12.64 | 239 | 112994 | 64074 | 64321425 |
Subileus | 53.10 | 12.64 | 54 | 113179 | 4923 | 64380576 |
Wheezing | 52.26 | 12.64 | 39 | 113194 | 80540 | 64304959 |
Somnolence | 52.10 | 12.64 | 183 | 113050 | 203462 | 64182037 |
Dermatitis acneiform | 51.96 | 12.64 | 69 | 113164 | 8374 | 64377125 |
Performance status decreased | 51.49 | 12.64 | 55 | 113178 | 5309 | 64380190 |
Gastric perforation | 50.50 | 12.64 | 45 | 113188 | 3478 | 64382021 |
Therapy partial responder | 50.08 | 12.64 | 75 | 113158 | 10173 | 64375326 |
Device related thrombosis | 49.96 | 12.64 | 36 | 113197 | 2049 | 64383450 |
Wound | 49.62 | 12.64 | 37 | 113196 | 76440 | 64309059 |
Chronic kidney disease | 49.19 | 12.64 | 20 | 113213 | 57899 | 64327600 |
Metastases to the mediastinum | 48.36 | 12.64 | 22 | 113211 | 512 | 64384987 |
Oesophagitis | 48.23 | 12.64 | 113 | 113120 | 21517 | 64363982 |
Abdominal lymphadenopathy | 48.20 | 12.64 | 28 | 113205 | 1098 | 64384401 |
Therapy change | 48.20 | 12.64 | 58 | 113175 | 6376 | 64379123 |
Wrong technique in product usage process | 48.20 | 12.64 | 27 | 113206 | 64947 | 64320552 |
Vascular pain | 47.63 | 12.64 | 25 | 113208 | 801 | 64384698 |
Pain | 47.58 | 12.64 | 685 | 112548 | 552826 | 63832673 |
Cytomegalovirus infection | 47.47 | 12.64 | 5 | 113228 | 37194 | 64348305 |
Oxygen saturation decreased | 47.05 | 12.64 | 72 | 113161 | 107104 | 64278395 |
Metastases to meninges | 46.51 | 12.64 | 39 | 113194 | 2776 | 64382723 |
Hyperkalaemia | 46.29 | 12.64 | 66 | 113167 | 101063 | 64284436 |
Injection site erythema | 46.26 | 12.64 | 34 | 113199 | 70766 | 64314733 |
Subacute cutaneous lupus erythematosus | 46.08 | 12.64 | 40 | 113193 | 2985 | 64382514 |
Irritable bowel syndrome | 45.27 | 12.64 | 6 | 113227 | 37363 | 64348136 |
Coronary artery disease | 44.99 | 12.64 | 25 | 113208 | 60408 | 64325091 |
Disseminated intravascular coagulation | 44.96 | 12.64 | 142 | 113091 | 32206 | 64353293 |
Metastases to chest wall | 44.78 | 12.64 | 19 | 113214 | 372 | 64385127 |
Varices oesophageal | 44.72 | 12.64 | 50 | 113183 | 5080 | 64380419 |
Loss of consciousness | 44.52 | 12.64 | 124 | 113109 | 148241 | 64237258 |
Lacrimation increased | 44.40 | 12.64 | 99 | 113134 | 18247 | 64367252 |
Swelling | 44.39 | 12.64 | 139 | 113094 | 160079 | 64225420 |
Delirium | 44.22 | 12.64 | 34 | 113199 | 69160 | 64316339 |
Peripheral sensory neuropathy | 44.21 | 12.64 | 75 | 113158 | 11303 | 64374196 |
Obstruction gastric | 44.18 | 12.64 | 29 | 113204 | 1417 | 64384082 |
Skin hyperpigmentation | 44.15 | 12.64 | 56 | 113177 | 6495 | 64379004 |
Jaw operation | 43.85 | 12.64 | 23 | 113210 | 736 | 64384763 |
Peritonitis | 43.54 | 12.64 | 119 | 113114 | 24904 | 64360595 |
Pericarditis | 43.53 | 12.64 | 28 | 113205 | 62488 | 64323011 |
Erythema | 43.47 | 12.64 | 511 | 112722 | 186559 | 64198940 |
Hiccups | 43.38 | 12.64 | 63 | 113170 | 8313 | 64377186 |
Biliary obstruction | 43.20 | 12.64 | 43 | 113190 | 3821 | 64381678 |
Myalgia | 42.97 | 12.64 | 139 | 113094 | 158478 | 64227021 |
Fibromyalgia | 42.66 | 12.64 | 6 | 113227 | 35725 | 64349774 |
Aggression | 42.58 | 12.64 | 14 | 113219 | 46218 | 64339281 |
Blood bilirubin increased | 42.55 | 12.64 | 207 | 113026 | 57346 | 64328153 |
Ejection fraction | 42.26 | 12.64 | 27 | 113206 | 1259 | 64384240 |
Device occlusion | 42.09 | 12.64 | 68 | 113165 | 9845 | 64375654 |
Infusion site induration | 41.84 | 12.64 | 23 | 113210 | 810 | 64384689 |
Neutropenic sepsis | 41.82 | 12.64 | 112 | 113121 | 23160 | 64362339 |
Mucosal disorder | 41.70 | 12.64 | 38 | 113195 | 3024 | 64382475 |
Abnormal behaviour | 41.70 | 12.64 | 5 | 113228 | 33617 | 64351882 |
Recurrent cancer | 41.55 | 12.64 | 34 | 113199 | 2339 | 64383160 |
Leukoencephalopathy | 41.44 | 12.64 | 56 | 113177 | 6911 | 64378588 |
Myocardial infarction | 41.08 | 12.64 | 151 | 113082 | 165670 | 64219829 |
Sedation | 41.02 | 12.64 | 11 | 113222 | 41451 | 64344048 |
Wound dehiscence | 40.84 | 12.64 | 51 | 113182 | 5823 | 64379676 |
Proteus infection | 40.82 | 12.64 | 29 | 113204 | 1614 | 64383885 |
Mucosal toxicity | 40.59 | 12.64 | 19 | 113214 | 473 | 64385026 |
Drug level increased | 40.23 | 12.64 | 6 | 113227 | 34190 | 64351309 |
Neutrophil count decreased | 39.90 | 12.64 | 252 | 112981 | 76944 | 64308555 |
Toxic leukoencephalopathy | 39.82 | 12.64 | 23 | 113210 | 892 | 64384607 |
General physical health deterioration | 39.66 | 12.64 | 540 | 112693 | 203885 | 64181614 |
Lactic acidosis | 39.46 | 12.64 | 30 | 113203 | 61380 | 64324119 |
Nasopharyngitis | 39.08 | 12.64 | 194 | 113039 | 195879 | 64189620 |
Arterial thrombosis | 38.78 | 12.64 | 33 | 113200 | 2397 | 64383102 |
Diaphragmatic spasm | 38.76 | 12.64 | 12 | 113221 | 89 | 64385410 |
Unresponsive to stimuli | 38.75 | 12.64 | 20 | 113213 | 50373 | 64335126 |
Pyogenic granuloma | 38.72 | 12.64 | 18 | 113215 | 441 | 64385058 |
Prothrombin level decreased | 38.71 | 12.64 | 27 | 113206 | 1459 | 64384040 |
Anastomotic fistula | 38.64 | 12.64 | 12 | 113221 | 90 | 64385409 |
Tooth extraction | 38.26 | 12.64 | 64 | 113169 | 9537 | 64375962 |
Pulmonary hypertension | 38.12 | 12.64 | 14 | 113219 | 43125 | 64342374 |
Sleep apnoea syndrome | 38.10 | 12.64 | 4 | 113229 | 29828 | 64355671 |
Eosinophilia | 37.86 | 12.64 | 10 | 113223 | 38066 | 64347433 |
Acute coronary syndrome | 37.85 | 12.64 | 96 | 113137 | 19214 | 64366285 |
Portal shunt | 37.81 | 12.64 | 11 | 113222 | 64 | 64385435 |
Discomfort | 37.79 | 12.64 | 52 | 113181 | 80826 | 64304673 |
Loss of personal independence in daily activities | 37.60 | 12.64 | 43 | 113190 | 72411 | 64313088 |
Dysphagia | 37.55 | 12.64 | 318 | 112915 | 106494 | 64279005 |
Depressed level of consciousness | 37.41 | 12.64 | 53 | 113180 | 81383 | 64304116 |
Infusion related reaction | 37.39 | 12.64 | 155 | 113078 | 164312 | 64221187 |
Biliary sepsis | 37.32 | 12.64 | 26 | 113207 | 1402 | 64384097 |
Cold dysaesthesia | 37.24 | 12.64 | 8 | 113225 | 8 | 64385491 |
Basal cell carcinoma | 37.24 | 12.64 | 5 | 113228 | 30833 | 64354666 |
Necrotising fasciitis | 36.65 | 12.64 | 46 | 113187 | 5280 | 64380219 |
Cholangitis | 36.54 | 12.64 | 67 | 113166 | 10735 | 64374764 |
Hepatic enzyme increased | 36.51 | 12.64 | 112 | 113121 | 129831 | 64255668 |
Platelet count decreased | 36.29 | 12.64 | 452 | 112781 | 167259 | 64218240 |
Mouth ulceration | 35.93 | 12.64 | 132 | 113101 | 32312 | 64353187 |
Hepatic failure | 35.89 | 12.64 | 192 | 113041 | 55202 | 64330297 |
Irritability | 35.88 | 12.64 | 10 | 113223 | 36736 | 64348763 |
Lymphoedema | 35.50 | 12.64 | 63 | 113170 | 9842 | 64375657 |
Splenorenal shunt | 35.47 | 12.64 | 8 | 113225 | 12 | 64385487 |
Drug ineffective for unapproved indication | 35.41 | 12.64 | 6 | 113227 | 31127 | 64354372 |
Treatment noncompliance | 35.35 | 12.64 | 16 | 113217 | 43466 | 64342033 |
Nervousness | 35.20 | 12.64 | 5 | 113228 | 29551 | 64355948 |
Injury | 35.16 | 12.64 | 28 | 113205 | 55964 | 64329535 |
Large intestine perforation | 35.09 | 12.64 | 72 | 113161 | 12532 | 64372967 |
Hallucination | 34.82 | 12.64 | 46 | 113187 | 72742 | 64312757 |
Duodenal ulcer perforation | 34.61 | 12.64 | 9 | 113224 | 34616 | 64350883 |
Hypophagia | 34.16 | 12.64 | 149 | 113084 | 39438 | 64346061 |
Product use in unapproved indication | 33.91 | 12.64 | 177 | 113056 | 176441 | 64209058 |
Hepatic atrophy | 33.90 | 12.64 | 16 | 113217 | 406 | 64385093 |
Induration | 33.76 | 12.64 | 26 | 113207 | 1638 | 64383861 |
Hypertriglyceridaemia | 33.57 | 12.64 | 66 | 113167 | 11139 | 64374360 |
Faecal volume decreased | 33.49 | 12.64 | 12 | 113221 | 146 | 64385353 |
Hyperhidrosis | 33.46 | 12.64 | 110 | 113123 | 124810 | 64260689 |
Blood uric acid decreased | 33.35 | 12.64 | 22 | 113211 | 1084 | 64384415 |
Blood glucose increased | 33.25 | 12.64 | 77 | 113156 | 97996 | 64287503 |
Small intestinal obstruction | 33.24 | 12.64 | 104 | 113129 | 23469 | 64362030 |
Cataract | 32.99 | 12.64 | 25 | 113208 | 51237 | 64334262 |
Nodular regenerative hyperplasia | 32.97 | 12.64 | 20 | 113213 | 850 | 64384649 |
Granulocyte count decreased | 32.81 | 12.64 | 23 | 113210 | 1253 | 64384246 |
Respiratory arrest | 32.64 | 12.64 | 27 | 113206 | 52958 | 64332541 |
Adnexa uteri mass | 32.63 | 12.64 | 14 | 113219 | 282 | 64385217 |
Dizziness | 32.62 | 12.64 | 545 | 112688 | 429618 | 63955881 |
Bone disorder | 32.51 | 12.64 | 83 | 113150 | 16676 | 64368823 |
Abdominal discomfort | 32.12 | 12.64 | 188 | 113045 | 182134 | 64203365 |
Pigmentation disorder | 32.00 | 12.64 | 40 | 113193 | 4572 | 64380927 |
Pharyngeal inflammation | 31.57 | 12.64 | 20 | 113213 | 919 | 64384580 |
Rectal tenesmus | 31.52 | 12.64 | 21 | 113212 | 1052 | 64384447 |
Lower respiratory tract infection | 31.51 | 12.64 | 75 | 113158 | 94539 | 64290960 |
Therapeutic product effect incomplete | 31.40 | 12.64 | 86 | 113147 | 103396 | 64282103 |
Hypervolaemia | 31.26 | 12.64 | 14 | 113219 | 38271 | 64347228 |
Pneumatosis intestinalis | 31.05 | 12.64 | 42 | 113191 | 5187 | 64380312 |
Metastases to ovary | 30.90 | 12.64 | 13 | 113220 | 249 | 64385250 |
Urinary tract infection | 30.88 | 12.64 | 259 | 112974 | 231337 | 64154162 |
Hypoalbuminaemia | 30.70 | 12.64 | 84 | 113149 | 17590 | 64367909 |
Abortion spontaneous | 30.54 | 12.64 | 4 | 113229 | 25139 | 64360360 |
Neoplasm malignant | 30.39 | 12.64 | 104 | 113129 | 24584 | 64360915 |
Skin reaction | 30.28 | 12.64 | 67 | 113166 | 12285 | 64373214 |
Pelvic fluid collection | 30.11 | 12.64 | 17 | 113216 | 631 | 64384868 |
Debridement | 29.96 | 12.64 | 24 | 113209 | 1602 | 64383897 |
Pancreatic neuroendocrine tumour metastatic | 29.94 | 12.64 | 10 | 113223 | 97 | 64385402 |
Electrocardiogram ST segment elevation | 29.74 | 12.64 | 49 | 113184 | 7210 | 64378289 |
Therapy interrupted | 29.74 | 12.64 | 90 | 113143 | 19946 | 64365553 |
Cachexia | 29.71 | 12.64 | 56 | 113177 | 9161 | 64376338 |
Emotional distress | 29.71 | 12.64 | 13 | 113220 | 36025 | 64349474 |
Plantar erythema | 29.42 | 12.64 | 13 | 113220 | 282 | 64385217 |
Jaundice | 29.32 | 12.64 | 165 | 113068 | 48347 | 64337152 |
Metastases to eye | 29.31 | 12.64 | 12 | 113221 | 214 | 64385285 |
Necrotising oesophagitis | 29.12 | 12.64 | 17 | 113216 | 673 | 64384826 |
Asthenopia | 29.05 | 12.64 | 26 | 113207 | 2021 | 64383478 |
Device issue | 29.01 | 12.64 | 3 | 113230 | 22645 | 64362854 |
Bone pain | 28.88 | 12.64 | 162 | 113071 | 47410 | 64338089 |
Clostridial infection | 28.72 | 12.64 | 40 | 113193 | 5079 | 64380420 |
Product prescribing error | 28.64 | 12.64 | 13 | 113220 | 35256 | 64350243 |
Pulmonary arterial hypertension | 28.61 | 12.64 | 5 | 113228 | 25362 | 64360137 |
Syncope | 28.59 | 12.64 | 161 | 113072 | 157474 | 64228025 |
Heart rate increased | 28.47 | 12.64 | 84 | 113149 | 98591 | 64286908 |
Eosinophil percentage increased | 28.35 | 12.64 | 22 | 113211 | 1402 | 64384097 |
Blood pressure systolic increased | 28.30 | 12.64 | 27 | 113206 | 49426 | 64336073 |
Protein urine | 27.98 | 12.64 | 21 | 113212 | 1273 | 64384226 |
Haematoma | 27.96 | 12.64 | 24 | 113209 | 46226 | 64339273 |
Thrombosis | 27.90 | 12.64 | 216 | 113017 | 70426 | 64315073 |
Anal erythema | 27.90 | 12.64 | 11 | 113222 | 177 | 64385322 |
Constipation | 27.83 | 12.64 | 561 | 112672 | 228776 | 64156723 |
Inappropriate schedule of product administration | 27.77 | 12.64 | 77 | 113156 | 92209 | 64293290 |
Weight decreased | 27.73 | 12.64 | 677 | 112556 | 285062 | 64100437 |
Psychotic disorder | 27.68 | 12.64 | 13 | 113220 | 34565 | 64350934 |
Angioedema | 27.64 | 12.64 | 41 | 113192 | 61780 | 64323719 |
Brachiocephalic vein thrombosis | 27.59 | 12.64 | 10 | 113223 | 126 | 64385373 |
Malignant ascites | 27.37 | 12.64 | 19 | 113214 | 1019 | 64384480 |
Neck pain | 27.33 | 12.64 | 41 | 113192 | 61492 | 64324007 |
Pleural effusion | 27.32 | 12.64 | 341 | 112892 | 126218 | 64259281 |
Prinzmetal angina | 27.30 | 12.64 | 22 | 113211 | 1481 | 64384018 |
Focal nodular hyperplasia | 27.23 | 12.64 | 16 | 113217 | 641 | 64384858 |
Fluid retention | 27.17 | 12.64 | 39 | 113194 | 59567 | 64325932 |
Aortic thrombosis | 27.16 | 12.64 | 22 | 113211 | 1492 | 64384007 |
Stress cardiomyopathy | 27.10 | 12.64 | 54 | 113179 | 9203 | 64376296 |
Angina bullosa haemorrhagica | 26.93 | 12.64 | 11 | 113222 | 195 | 64385304 |
Ectropion | 26.87 | 12.64 | 13 | 113220 | 349 | 64385150 |
Gastrointestinal stoma necrosis | 26.73 | 12.64 | 5 | 113228 | 0 | 64385499 |
Cryptitis | 26.70 | 12.64 | 9 | 113224 | 90 | 64385409 |
Hyperfibrinolysis | 26.62 | 12.64 | 7 | 113226 | 26 | 64385473 |
Acute respiratory failure | 26.60 | 12.64 | 29 | 113204 | 49905 | 64335594 |
Tumour pain | 26.34 | 12.64 | 24 | 113209 | 1909 | 64383590 |
Colorectal cancer metastatic | 26.32 | 12.64 | 18 | 113215 | 942 | 64384557 |
Hypoglycaemia | 26.31 | 12.64 | 76 | 113157 | 89816 | 64295683 |
Oesophageal haemorrhage | 26.29 | 12.64 | 22 | 113211 | 1562 | 64383937 |
Vein disorder | 26.07 | 12.64 | 34 | 113199 | 4053 | 64381446 |
Pulmonary mass | 26.00 | 12.64 | 97 | 113136 | 23919 | 64361580 |
Stoma site haemorrhage | 25.94 | 12.64 | 22 | 113211 | 1591 | 64383908 |
Tooth erosion | 25.80 | 12.64 | 13 | 113220 | 382 | 64385117 |
Early satiety | 25.78 | 12.64 | 19 | 113214 | 1120 | 64384379 |
Atrial fibrillation | 25.76 | 12.64 | 185 | 113048 | 170904 | 64214595 |
Gastrointestinal inflammation | 25.63 | 12.64 | 42 | 113191 | 6153 | 64379346 |
Respiratory depression | 25.62 | 12.64 | 5 | 113228 | 23438 | 64362061 |
Medication error | 25.55 | 12.64 | 30 | 113203 | 49936 | 64335563 |
Blood creatinine decreased | 25.47 | 12.64 | 45 | 113188 | 7005 | 64378494 |
Venoocclusive liver disease | 25.31 | 12.64 | 55 | 113178 | 9960 | 64375539 |
Nail infection | 25.30 | 12.64 | 23 | 113210 | 1824 | 64383675 |
Bone sequestrum | 25.29 | 12.64 | 19 | 113214 | 1153 | 64384346 |
Prescribed overdose | 25.27 | 12.64 | 3 | 113230 | 20328 | 64365171 |
Disturbance in attention | 25.21 | 12.64 | 21 | 113212 | 41053 | 64344446 |
Rectal perforation | 25.08 | 12.64 | 16 | 113217 | 744 | 64384755 |
Onychomadesis | 24.95 | 12.64 | 28 | 113205 | 2856 | 64382643 |
Vessel puncture site bruise | 24.93 | 12.64 | 13 | 113220 | 411 | 64385088 |
Injection site haemorrhage | 24.86 | 12.64 | 6 | 113227 | 24272 | 64361227 |
Accidental overdose | 24.80 | 12.64 | 14 | 113219 | 33543 | 64351956 |
Post-traumatic neck syndrome | 24.73 | 12.64 | 23 | 113210 | 1879 | 64383620 |
COVID-19 | 24.71 | 12.64 | 48 | 113185 | 65092 | 64320407 |
Metastases to pelvis | 24.69 | 12.64 | 14 | 113219 | 524 | 64384975 |
Dysgeusia | 24.56 | 12.64 | 154 | 113079 | 46893 | 64338606 |
Adverse event | 24.48 | 12.64 | 20 | 113213 | 39469 | 64346030 |
Steatohepatitis | 24.13 | 12.64 | 16 | 113217 | 795 | 64384704 |
Cardio-respiratory arrest | 24.09 | 12.64 | 90 | 113143 | 98303 | 64287196 |
Extrapyramidal disorder | 24.02 | 12.64 | 3 | 113230 | 19549 | 64365950 |
Upper respiratory tract infection | 23.99 | 12.64 | 58 | 113175 | 72727 | 64312772 |
Vasodilatation | 23.92 | 12.64 | 28 | 113205 | 2990 | 64382509 |
Hospitalisation | 23.89 | 12.64 | 219 | 113014 | 74988 | 64310511 |
Cytokine release syndrome | 23.72 | 12.64 | 4 | 113229 | 20825 | 64364674 |
Contusion | 23.71 | 12.64 | 111 | 113122 | 113854 | 64271645 |
Tenderness | 23.62 | 12.64 | 82 | 113151 | 19520 | 64365979 |
Restlessness | 23.62 | 12.64 | 21 | 113212 | 39764 | 64345735 |
Hand-foot-and-mouth disease | 23.47 | 12.64 | 10 | 113223 | 198 | 64385301 |
Acute myeloid leukaemia | 23.41 | 12.64 | 103 | 113130 | 27360 | 64358139 |
Carbohydrate antigen 19-9 increased | 23.37 | 12.64 | 12 | 113221 | 367 | 64385132 |
Human epidermal growth factor receptor negative | 23.28 | 12.64 | 5 | 113228 | 5 | 64385494 |
Ileal ulcer | 23.23 | 12.64 | 17 | 113216 | 991 | 64384508 |
Large intestinal obstruction | 22.98 | 12.64 | 26 | 113207 | 2676 | 64382823 |
Dental care | 22.98 | 12.64 | 15 | 113218 | 726 | 64384773 |
Cardiac output decreased | 22.92 | 12.64 | 21 | 113212 | 1683 | 64383816 |
Osteoporosis | 22.90 | 12.64 | 24 | 113209 | 42056 | 64343443 |
Tendonitis | 22.87 | 12.64 | 4 | 113229 | 20278 | 64365221 |
Fistula | 22.86 | 12.64 | 52 | 113181 | 9709 | 64375790 |
Right ventricular failure | 22.60 | 12.64 | 5 | 113228 | 21466 | 64364033 |
Colon cancer recurrent | 22.58 | 12.64 | 8 | 113225 | 94 | 64385405 |
Accidental exposure to product | 22.55 | 12.64 | 9 | 113224 | 26355 | 64359144 |
Haemorrhage intracranial | 22.41 | 12.64 | 7 | 113226 | 23877 | 64361622 |
Hyperammonaemia | 22.36 | 12.64 | 52 | 113181 | 9852 | 64375647 |
Renal hydrocele | 22.27 | 12.64 | 6 | 113227 | 25 | 64385474 |
Failure to anastomose | 22.25 | 12.64 | 10 | 113223 | 226 | 64385273 |
Coma | 22.20 | 12.64 | 79 | 113154 | 87536 | 64297963 |
Abdominal distension | 22.17 | 12.64 | 262 | 112971 | 95732 | 64289767 |
Metastatic gastric cancer | 21.90 | 12.64 | 11 | 113222 | 321 | 64385178 |
White blood cell count decreased | 21.84 | 12.64 | 394 | 112839 | 157443 | 64228056 |
Hepatitis | 21.60 | 12.64 | 29 | 113204 | 45553 | 64339946 |
Drug eruption | 21.54 | 12.64 | 19 | 113214 | 36117 | 64349382 |
Cognitive disorder | 21.41 | 12.64 | 40 | 113193 | 55047 | 64330452 |
Radiation myelopathy | 21.39 | 12.64 | 4 | 113229 | 0 | 64385499 |
Poisoning | 21.28 | 12.64 | 6 | 113227 | 21873 | 64363626 |
Peripheral ischaemia | 21.16 | 12.64 | 46 | 113187 | 8332 | 64377167 |
Intestinal metastasis | 21.14 | 12.64 | 10 | 113223 | 255 | 64385244 |
ECG signs of myocardial ischaemia | 21.09 | 12.64 | 11 | 113222 | 348 | 64385151 |
Haemoglobin decreased | 20.96 | 12.64 | 230 | 113003 | 194833 | 64190666 |
Eye pain | 20.90 | 12.64 | 15 | 113218 | 31610 | 64353889 |
Gastrointestinal disorder | 20.79 | 12.64 | 245 | 112988 | 89464 | 64296035 |
Febrile neutropenia | 20.78 | 12.64 | 453 | 112780 | 187204 | 64198295 |
Limbal stem cell deficiency | 20.76 | 12.64 | 6 | 113227 | 34 | 64385465 |
Toxicity to various agents | 20.72 | 12.64 | 483 | 112750 | 363030 | 64022469 |
Neoplasm recurrence | 20.65 | 12.64 | 29 | 113204 | 3710 | 64381789 |
Anal prolapse | 20.59 | 12.64 | 7 | 113226 | 72 | 64385427 |
No adverse event | 20.59 | 12.64 | 102 | 113131 | 28459 | 64357040 |
Osteolysis | 20.56 | 12.64 | 25 | 113208 | 2778 | 64382721 |
Gastrointestinal mucosal necrosis | 20.50 | 12.64 | 9 | 113224 | 192 | 64385307 |
Temperature intolerance | 20.48 | 12.64 | 45 | 113188 | 8210 | 64377289 |
Periportal sinus dilatation | 20.33 | 12.64 | 6 | 113227 | 37 | 64385462 |
Hyperammonaemic encephalopathy | 20.26 | 12.64 | 30 | 113203 | 4028 | 64381471 |
Transaminases | 20.25 | 12.64 | 7 | 113226 | 76 | 64385423 |
Hallucination, visual | 20.02 | 12.64 | 12 | 113221 | 27822 | 64357677 |
Obstructive airways disorder | 19.69 | 12.64 | 8 | 113225 | 23177 | 64362322 |
Oral pain | 19.68 | 12.64 | 98 | 113135 | 27395 | 64358104 |
Intestinal dilatation | 19.62 | 12.64 | 22 | 113211 | 2242 | 64383257 |
Rhinorrhoea | 19.60 | 12.64 | 48 | 113185 | 59921 | 64325578 |
Disease recurrence | 19.59 | 12.64 | 108 | 113125 | 31402 | 64354097 |
Injection site bruising | 19.51 | 12.64 | 21 | 113212 | 36352 | 64349147 |
Hormone receptor positive breast cancer | 19.41 | 12.64 | 10 | 113223 | 308 | 64385191 |
Hepatic infarction | 19.38 | 12.64 | 14 | 113219 | 800 | 64384699 |
Infusion site hypoaesthesia | 19.36 | 12.64 | 5 | 113228 | 17 | 64385482 |
Pancreatitis viral | 19.36 | 12.64 | 5 | 113228 | 17 | 64385482 |
Stress | 19.35 | 12.64 | 49 | 113184 | 60485 | 64325014 |
Sinus bradycardia | 19.28 | 12.64 | 8 | 113225 | 22885 | 64362614 |
Generalised tonic-clonic seizure | 19.25 | 12.64 | 25 | 113208 | 39832 | 64345667 |
Viral infection | 19.24 | 12.64 | 21 | 113212 | 36119 | 64349380 |
Productive cough | 19.23 | 12.64 | 65 | 113168 | 73138 | 64312361 |
Ventricular fibrillation | 19.22 | 12.64 | 88 | 113145 | 23772 | 64361727 |
Infusion site haemorrhage | 19.22 | 12.64 | 22 | 113211 | 2293 | 64383206 |
Exposed bone in jaw | 19.19 | 12.64 | 27 | 113206 | 3460 | 64382039 |
Hypersplenism | 19.06 | 12.64 | 11 | 113222 | 426 | 64385073 |
Bone debridement | 18.87 | 12.64 | 11 | 113222 | 434 | 64385065 |
Hypoacusis | 18.82 | 12.64 | 11 | 113222 | 25856 | 64359643 |
Incorrect dose administered | 18.80 | 12.64 | 50 | 113183 | 60715 | 64324784 |
Metastases to breast | 18.80 | 12.64 | 9 | 113224 | 236 | 64385263 |
Brain neoplasm | 18.75 | 12.64 | 32 | 113201 | 4846 | 64380653 |
Dyskinesia | 18.72 | 12.64 | 25 | 113208 | 39363 | 64346136 |
Vertebral column mass | 18.70 | 12.64 | 8 | 113225 | 160 | 64385339 |
Metastases to adrenals | 18.68 | 12.64 | 16 | 113217 | 1173 | 64384326 |
Gingival bleeding | 18.65 | 12.64 | 63 | 113170 | 14791 | 64370708 |
Crying | 18.65 | 12.64 | 6 | 113227 | 20084 | 64365415 |
Renal vein thrombosis | 18.60 | 12.64 | 11 | 113222 | 446 | 64385053 |
Toothache | 18.47 | 12.64 | 70 | 113163 | 17389 | 64368110 |
Computerised tomogram abnormal | 18.46 | 12.64 | 25 | 113208 | 3091 | 64382408 |
Ear infection | 18.43 | 12.64 | 9 | 113224 | 23395 | 64362104 |
Lymphadenopathy mediastinal | 18.42 | 12.64 | 28 | 113205 | 3848 | 64381651 |
Pneumocystis jirovecii pneumonia | 18.40 | 12.64 | 13 | 113220 | 27621 | 64357878 |
Metastases to stomach | 18.36 | 12.64 | 9 | 113224 | 249 | 64385250 |
Hepatic cyst | 18.36 | 12.64 | 33 | 113200 | 5207 | 64380292 |
Oral pigmentation | 18.34 | 12.64 | 5 | 113228 | 22 | 64385477 |
Migraine | 18.33 | 12.64 | 53 | 113180 | 62624 | 64322875 |
Incorrect route of product administration | 18.28 | 12.64 | 9 | 113224 | 23289 | 64362210 |
Premature delivery | 18.26 | 12.64 | 5 | 113228 | 18584 | 64366915 |
Panic attack | 18.17 | 12.64 | 7 | 113226 | 20946 | 64364553 |
Metastases to thorax | 18.13 | 12.64 | 8 | 113225 | 173 | 64385326 |
Pregnancy | 18.05 | 12.64 | 7 | 113226 | 20858 | 64364641 |
Odynophagia | 17.93 | 12.64 | 47 | 113186 | 9594 | 64375905 |
Tremor | 17.89 | 12.64 | 170 | 113063 | 148060 | 64237439 |
Malignant pleural effusion | 17.88 | 12.64 | 24 | 113209 | 2943 | 64382556 |
Peripheral motor neuropathy | 17.86 | 12.64 | 24 | 113209 | 2946 | 64382553 |
Cerebrovascular accident | 17.81 | 12.64 | 155 | 113078 | 137428 | 64248071 |
Congestive cardiomyopathy | 17.80 | 12.64 | 49 | 113184 | 10295 | 64375204 |
Joint injury | 17.80 | 12.64 | 9 | 113224 | 22938 | 64362561 |
International normalised ratio increased | 17.74 | 12.64 | 75 | 113158 | 79092 | 64306407 |
C-reactive protein increased | 17.71 | 12.64 | 96 | 113137 | 94813 | 64290686 |
Motion sickness | 17.66 | 12.64 | 13 | 113220 | 765 | 64384734 |
Perineal ulceration | 17.62 | 12.64 | 6 | 113227 | 62 | 64385437 |
Obesity | 17.62 | 12.64 | 7 | 113226 | 20555 | 64364944 |
Head injury | 17.57 | 12.64 | 19 | 113214 | 32823 | 64352676 |
Joint range of motion decreased | 17.56 | 12.64 | 6 | 113227 | 19337 | 64366162 |
Prostatic calcification | 17.54 | 12.64 | 6 | 113227 | 63 | 64385436 |
Mydriasis | 17.31 | 12.64 | 3 | 113230 | 15309 | 64370190 |
Venous thrombosis limb | 17.22 | 12.64 | 27 | 113206 | 3810 | 64381689 |
Herpangina | 17.20 | 12.64 | 5 | 113228 | 29 | 64385470 |
Gastroenteropancreatic neuroendocrine tumour disease | 17.20 | 12.64 | 5 | 113228 | 29 | 64385470 |
Sciatica | 17.20 | 12.64 | 7 | 113226 | 20257 | 64365242 |
Sputum discoloured | 17.17 | 12.64 | 5 | 113228 | 17851 | 64367648 |
Urinary incontinence | 17.13 | 12.64 | 23 | 113210 | 36128 | 64349371 |
Perforation | 17.13 | 12.64 | 15 | 113218 | 1133 | 64384366 |
Gastroenteritis radiation | 17.11 | 12.64 | 12 | 113221 | 654 | 64384845 |
Diabetes mellitus inadequate control | 17.09 | 12.64 | 8 | 113225 | 21313 | 64364186 |
Foot deformity | 17.06 | 12.64 | 4 | 113229 | 16500 | 64368999 |
Staphylococcal infection | 17.00 | 12.64 | 40 | 113193 | 50638 | 64334861 |
Lymphadenopathy | 16.93 | 12.64 | 140 | 113093 | 46546 | 64338953 |
Device dislocation | 16.89 | 12.64 | 8 | 113225 | 21170 | 64364329 |
Dyspnoea | 16.89 | 12.64 | 1062 | 112171 | 717612 | 63667887 |
Hyperaesthesia | 16.80 | 12.64 | 47 | 113186 | 9967 | 64375532 |
Gastric dilatation | 16.79 | 12.64 | 15 | 113218 | 1163 | 64384336 |
Cough | 16.78 | 12.64 | 403 | 112830 | 301745 | 64083754 |
Blood creatine phosphokinase increased | 16.78 | 12.64 | 50 | 113183 | 58508 | 64326991 |
Enterocolitis haemorrhagic | 16.75 | 12.64 | 19 | 113214 | 1961 | 64383538 |
Breast necrosis | 16.67 | 12.64 | 6 | 113227 | 74 | 64385425 |
Pericardial effusion | 16.61 | 12.64 | 122 | 113111 | 39132 | 64346367 |
Acute promyelocytic leukaemia | 16.55 | 12.64 | 16 | 113217 | 1372 | 64384127 |
Respiratory tract congestion | 16.54 | 12.64 | 4 | 113229 | 16161 | 64369338 |
Folliculitis | 16.54 | 12.64 | 17 | 113216 | 30060 | 64355439 |
Hypoxia | 16.54 | 12.64 | 89 | 113144 | 88060 | 64297439 |
Oropharyngeal pain | 16.52 | 12.64 | 90 | 113143 | 88777 | 64296722 |
Myoclonus | 16.48 | 12.64 | 12 | 113221 | 25106 | 64360393 |
Disorientation | 16.48 | 12.64 | 47 | 113186 | 55781 | 64329718 |
Torsade de pointes | 16.45 | 12.64 | 5 | 113228 | 17358 | 64368141 |
Blood pressure increased | 16.40 | 12.64 | 209 | 113024 | 172343 | 64213156 |
Back pain | 16.39 | 12.64 | 325 | 112908 | 249846 | 64135653 |
Dark circles under eyes | 16.32 | 12.64 | 10 | 113223 | 433 | 64385066 |
Pancreatic fistula | 16.31 | 12.64 | 6 | 113227 | 79 | 64385420 |
Seizure | 16.29 | 12.64 | 201 | 113032 | 166691 | 64218808 |
Toxic epidermal necrolysis | 16.27 | 12.64 | 25 | 113208 | 37141 | 64348358 |
Biliary fistula | 16.18 | 12.64 | 6 | 113227 | 81 | 64385418 |
Restless legs syndrome | 16.08 | 12.64 | 5 | 113228 | 17111 | 64368388 |
Hyperchylomicronaemia | 16.04 | 12.64 | 3 | 113230 | 0 | 64385499 |
Dermatoglyphic anomaly | 16.04 | 12.64 | 3 | 113230 | 0 | 64385499 |
Urethral ulcer | 16.04 | 12.64 | 3 | 113230 | 0 | 64385499 |
Haemodialysis | 16.03 | 12.64 | 5 | 113228 | 17072 | 64368427 |
Ataxia | 16.01 | 12.64 | 79 | 113154 | 22005 | 64363494 |
Gallbladder disorder | 15.96 | 12.64 | 5 | 113228 | 17025 | 64368474 |
Paraneoplastic dermatomyositis | 15.93 | 12.64 | 5 | 113228 | 39 | 64385460 |
Product administration error | 15.92 | 12.64 | 15 | 113218 | 27628 | 64357871 |
Hyperthyroidism | 15.89 | 12.64 | 6 | 113227 | 18173 | 64367326 |
Dermatomyositis | 15.85 | 12.64 | 22 | 113211 | 2784 | 64382715 |
Parkinsonism | 15.85 | 12.64 | 3 | 113230 | 14370 | 64371129 |
Small intestinal perforation | 15.74 | 12.64 | 21 | 113212 | 2559 | 64382940 |
Delusion | 15.66 | 12.64 | 6 | 113227 | 18008 | 64367491 |
Tumour invasion | 15.65 | 12.64 | 9 | 113224 | 346 | 64385153 |
Mental disorder | 15.65 | 12.64 | 14 | 113219 | 26431 | 64359068 |
Liver injury | 15.64 | 12.64 | 98 | 113135 | 29834 | 64355665 |
Mechanical ileus | 15.60 | 12.64 | 11 | 113222 | 605 | 64384894 |
Bronchopulmonary aspergillosis | 15.55 | 12.64 | 7 | 113226 | 19078 | 64366421 |
Vasospasm | 15.51 | 12.64 | 13 | 113220 | 925 | 64384574 |
Lymphocyte count decreased | 15.42 | 12.64 | 30 | 113203 | 40669 | 64344830 |
Hyperglycaemic hyperosmolar nonketotic syndrome | 15.41 | 12.64 | 17 | 113216 | 1702 | 64383797 |
Epistaxis | 15.39 | 12.64 | 250 | 112983 | 97881 | 64287618 |
Multiple sclerosis | 15.35 | 12.64 | 7 | 113226 | 18934 | 64366565 |
Subdural haematoma | 15.27 | 12.64 | 16 | 113217 | 28038 | 64357461 |
Dystonia | 15.24 | 12.64 | 7 | 113226 | 18858 | 64366641 |
Calcium ionised increased | 15.23 | 12.64 | 7 | 113226 | 167 | 64385332 |
Injection site swelling | 15.23 | 12.64 | 31 | 113202 | 41322 | 64344177 |
Vulval disorder | 15.23 | 12.64 | 10 | 113223 | 489 | 64385010 |
Terminal ileitis | 15.22 | 12.64 | 11 | 113222 | 629 | 64384870 |
Colitis ischaemic | 15.21 | 12.64 | 55 | 113178 | 13359 | 64372140 |
Hypermutation | 15.20 | 12.64 | 5 | 113228 | 46 | 64385453 |
Fungal infection | 15.03 | 12.64 | 23 | 113210 | 34228 | 64351271 |
Nail avulsion | 15.03 | 12.64 | 6 | 113227 | 100 | 64385399 |
Liver scan abnormal | 15.01 | 12.64 | 5 | 113228 | 48 | 64385451 |
Prostate cancer | 15.01 | 12.64 | 8 | 113225 | 19787 | 64365712 |
Paranoia | 14.97 | 12.64 | 5 | 113228 | 16347 | 64369152 |
Dermatitis | 14.90 | 12.64 | 67 | 113166 | 17962 | 64367537 |
Mood swings | 14.88 | 12.64 | 6 | 113227 | 17462 | 64368037 |
Rectal neoplasm | 14.83 | 12.64 | 5 | 113228 | 50 | 64385449 |
Gastrointestinal injury | 14.82 | 12.64 | 12 | 113221 | 813 | 64384686 |
Anhedonia | 14.82 | 12.64 | 3 | 113230 | 13703 | 64371796 |
Acral peeling skin syndrome | 14.74 | 12.64 | 5 | 113228 | 51 | 64385448 |
Memory impairment | 14.73 | 12.64 | 89 | 113144 | 85593 | 64299906 |
Pharyngeal ulceration | 14.71 | 12.64 | 12 | 113221 | 822 | 64384677 |
Glomerular filtration rate decreased | 14.70 | 12.64 | 8 | 113225 | 19564 | 64365935 |
Chemical peritonitis | 14.70 | 12.64 | 8 | 113225 | 276 | 64385223 |
Radiation fibrosis - lung | 14.66 | 12.64 | 5 | 113228 | 52 | 64385447 |
Appendicitis noninfective | 14.60 | 12.64 | 4 | 113229 | 18 | 64385481 |
Pulpitis dental | 14.57 | 12.64 | 13 | 113220 | 1006 | 64384493 |
Liver abscess | 14.51 | 12.64 | 30 | 113203 | 5250 | 64380249 |
Nail bed inflammation | 14.49 | 12.64 | 10 | 113223 | 531 | 64384968 |
Femoral artery embolism | 14.49 | 12.64 | 5 | 113228 | 54 | 64385445 |
Hyperbaric oxygen therapy | 14.41 | 12.64 | 5 | 113228 | 55 | 64385444 |
Peritoneal fluid analysis abnormal | 14.41 | 12.64 | 5 | 113228 | 55 | 64385444 |
Schistosomiasis | 14.33 | 12.64 | 5 | 113228 | 56 | 64385443 |
Periodontitis | 14.32 | 12.64 | 26 | 113207 | 4133 | 64381366 |
Hypothalamo-pituitary disorder | 14.30 | 12.64 | 13 | 113220 | 1031 | 64384468 |
Proctalgia | 14.21 | 12.64 | 37 | 113196 | 7522 | 64377977 |
Peripheral sensorimotor neuropathy | 14.20 | 12.64 | 20 | 113213 | 2565 | 64382934 |
Tumour marker abnormal | 14.20 | 12.64 | 7 | 113226 | 196 | 64385303 |
Diverticulitis | 14.18 | 12.64 | 29 | 113204 | 38589 | 64346910 |
Administration site extravasation | 14.14 | 12.64 | 13 | 113220 | 1046 | 64384453 |
Blood lactate dehydrogenase increased | 14.11 | 12.64 | 103 | 113130 | 32975 | 64352524 |
Short-bowel syndrome | 14.10 | 12.64 | 9 | 113224 | 419 | 64385080 |
Botryomycosis | 14.09 | 12.64 | 5 | 113228 | 59 | 64385440 |
Acute hepatic failure | 14.09 | 12.64 | 15 | 113218 | 26097 | 64359402 |
Increased liver stiffness | 13.97 | 12.64 | 3 | 113230 | 3 | 64385496 |
Metaplastic breast carcinoma | 13.97 | 12.64 | 3 | 113230 | 3 | 64385496 |
Abdominal fat apron | 13.97 | 12.64 | 3 | 113230 | 3 | 64385496 |
Neutrophilia | 13.87 | 12.64 | 34 | 113199 | 6660 | 64378839 |
Proctitis | 13.86 | 12.64 | 22 | 113211 | 3137 | 64382362 |
Type 2 diabetes mellitus | 13.85 | 12.64 | 24 | 113209 | 33996 | 64351503 |
Neoplasm | 13.82 | 12.64 | 35 | 113198 | 6996 | 64378503 |
Onychoclasis | 13.70 | 12.64 | 27 | 113206 | 4565 | 64380934 |
Ureteric obstruction | 13.70 | 12.64 | 19 | 113214 | 2403 | 64383096 |
Brain operation | 13.70 | 12.64 | 10 | 113223 | 581 | 64384918 |
Diabetes mellitus | 13.67 | 12.64 | 65 | 113168 | 66409 | 64319090 |
Pituitary tumour | 13.66 | 12.64 | 13 | 113220 | 1093 | 64384406 |
Hydronephrosis | 13.61 | 12.64 | 55 | 113178 | 14070 | 64371429 |
Genital erythema | 13.52 | 12.64 | 7 | 113226 | 218 | 64385281 |
Radioisotope scan | 13.51 | 12.64 | 3 | 113230 | 4 | 64385495 |
Influenza like illness | 13.49 | 12.64 | 59 | 113174 | 61643 | 64323856 |
Blood cholesterol increased | 13.46 | 12.64 | 44 | 113189 | 50022 | 64335477 |
Skin disorder | 13.46 | 12.64 | 89 | 113144 | 27591 | 64357908 |
Actinomycosis | 13.44 | 12.64 | 12 | 113221 | 930 | 64384569 |
Electrolyte imbalance | 13.40 | 12.64 | 83 | 113150 | 25160 | 64360339 |
Acute generalised exanthematous pustulosis | 13.40 | 12.64 | 4 | 113229 | 14054 | 64371445 |
Skin burning sensation | 13.39 | 12.64 | 45 | 113188 | 10538 | 64374961 |
Status epilepticus | 13.39 | 12.64 | 11 | 113222 | 21652 | 64363847 |
Metastases to bladder | 13.35 | 12.64 | 7 | 113226 | 224 | 64385275 |
Stoma complication | 13.33 | 12.64 | 9 | 113224 | 461 | 64385038 |
Orthostatic hypotension | 13.32 | 12.64 | 40 | 113193 | 46698 | 64338801 |
Uveitis | 13.29 | 12.64 | 3 | 113230 | 12705 | 64372794 |
Uterine enlargement | 13.28 | 12.64 | 11 | 113222 | 770 | 64384729 |
Amnesia | 13.27 | 12.64 | 42 | 113191 | 48227 | 64337272 |
Limb injury | 13.25 | 12.64 | 13 | 113220 | 23492 | 64362007 |
Adrenal insufficiency | 13.19 | 12.64 | 12 | 113221 | 22475 | 64363024 |
Lung neoplasm malignant | 13.12 | 12.64 | 11 | 113222 | 21437 | 64364062 |
Pleural neoplasm | 13.12 | 12.64 | 7 | 113226 | 232 | 64385267 |
Cardiac arrest | 13.05 | 12.64 | 191 | 113042 | 153873 | 64231626 |
Skin sensitisation | 13.05 | 12.64 | 11 | 113222 | 789 | 64384710 |
Malignant peritoneal neoplasm | 13.00 | 12.64 | 10 | 113223 | 629 | 64384870 |
Tumour excision | 12.96 | 12.64 | 9 | 113224 | 483 | 64385016 |
Rash maculo-papular | 12.87 | 12.64 | 41 | 113192 | 46985 | 64338514 |
Liver function test abnormal | 12.86 | 12.64 | 57 | 113176 | 59344 | 64326155 |
Subclavian vein thrombosis | 12.86 | 12.64 | 18 | 113215 | 2296 | 64383203 |
Fistula of small intestine | 12.78 | 12.64 | 10 | 113223 | 645 | 64384854 |
Renal tubular necrosis | 12.73 | 12.64 | 12 | 113221 | 22098 | 64363401 |
Dysphonia | 12.73 | 12.64 | 131 | 113102 | 46251 | 64339248 |
Herpes zoster | 12.71 | 12.64 | 84 | 113149 | 79103 | 64306396 |
Gastrointestinal oedema | 12.70 | 12.64 | 18 | 113215 | 2322 | 64383177 |
None
Source | Code | Description |
---|---|---|
ATC | L01BC06 | ANTINEOPLASTIC AND IMMUNOMODULATING AGENTS ANTINEOPLASTIC AGENTS ANTIMETABOLITES Pyrimidine analogues |
FDA MoA | N0000000233 | Nucleic Acid Synthesis Inhibitors |
FDA EPC | N0000175595 | Nucleoside Metabolic Inhibitor |
MeSH PA | D000963 | Antimetabolites |
MeSH PA | D000964 | Antimetabolites, Antineoplastic |
MeSH PA | D000970 | Antineoplastic Agents |
MeSH PA | D009676 | Noxae |
CHEBI has role | CHEBI:35221 | antimetabolite |
CHEBI has role | CHEBI:35610 | antineoplastic agents |
CHEBI has role | CHEBI:50266 | Prodrugs |
Disease | Relation | SNOMED_ID | DOID |
---|---|---|---|
Metastasis from malignant tumor of colon | indication | 314998002 | |
Malignant tumor of stomach | indication | 363349007 | DOID:10534 |
Metastatic Breast Carcinoma | indication | ||
Lymph Node Positive Colorectal Carcinoma | indication | ||
Malignant tumor of ovary | off-label use | 363443007 | DOID:2394 |
Adenocarcinoma of pancreas | off-label use | 700423003 | DOID:4074 |
Pancreatic Neuroendocrine Tumor | off-label use | 717919005 | |
Necrotizing enterocolitis in fetus OR newborn | contraindication | 2707005 | |
Hyperbilirubinemia | contraindication | 14783006 | DOID:2741 |
Infectious disease | contraindication | 40733004 | |
Conduction disorder of the heart | contraindication | 44808001 | |
Acute nephropathy | contraindication | 58574008 | |
Stomatitis | contraindication | 61170000 | DOID:9637 |
Dihydrouracil dehydrogenase (NADP^+^) deficiency | contraindication | 77365006 | DOID:14218 |
Impaired renal function disorder | contraindication | 197663003 | |
Disease of liver | contraindication | 235856003 | DOID:409 |
Anemia | contraindication | 271737000 | DOID:2355 |
Pregnancy, function | contraindication | 289908002 | |
Thrombocytopenic disorder | contraindication | 302215000 | DOID:1588 |
Neutropenic disorder | contraindication | 303011007 | DOID:1227 |
Severe diarrhea | contraindication | 409587002 | |
Breastfeeding (mother) | contraindication | 413712001 | |
Disorder of coronary artery | contraindication | 414024009 | |
Palmar-Plantar Erythrodysesthesia | contraindication |
None
None
Dissociation level | Dissociation constant | Type (acidic/basic) |
---|---|---|
pKa1 | 12.3 | acidic |
pKa2 | 12.91 | acidic |
pKa3 | 13.46 | acidic |
pKa4 | 0.75 | Basic |
None
None
Target | Class | Pharos | UniProt | Action | Type | Activity value (-log[M]) | Mechanism action | Bioact source | MoA source |
---|---|---|---|---|---|---|---|---|---|
Thymidylate synthase | Enzyme | INHIBITOR | WOMBAT-PK | CHEMBL |
ID | Source |
---|---|
4021099 | VUID |
N0000148555 | NUI |
D01223 | KEGG_DRUG |
194000 | RXNORM |
C0671970 | UMLSCUI |
CHEBI:31348 | CHEBI |
CHEMBL1773 | ChEMBL_ID |
DB01101 | DRUGBANK_ID |
D000069287 | MESH_DESCRIPTOR_UI |
60953 | PUBCHEM_CID |
6799 | IUPHAR_LIGAND_ID |
7317 | INN_ID |
6804DJ8Z9U | UNII |
11693 | MMSL |
210675 | MMSL |
4344 | MMSL |
d04311 | MMSL |
007533 | NDDF |
108761006 | SNOMEDCT_US |
386906001 | SNOMEDCT_US |
4021099 | VANDF |
Product | Category | Ingredients | NDC | Form | Quantity | Route | Marketing | Label |
---|---|---|---|---|---|---|---|---|
Xeloda | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0004-1100 | TABLET, FILM COATED | 150 mg | ORAL | NDA | 29 sections |
Xeloda | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0004-1101 | TABLET, FILM COATED | 500 mg | ORAL | NDA | 29 sections |
Capecitabine | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0054-0271 | TABLET, FILM COATED | 150 mg | ORAL | ANDA | 28 sections |
Capecitabine | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0054-0271 | TABLET, FILM COATED | 150 mg | ORAL | ANDA | 28 sections |
Capecitabine | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0054-0272 | TABLET, FILM COATED | 500 mg | ORAL | ANDA | 28 sections |
Capecitabine | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0054-0272 | TABLET, FILM COATED | 500 mg | ORAL | ANDA | 28 sections |
Capecitabine | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0093-7473 | TABLET, FILM COATED | 150 mg | ORAL | ANDA | 28 sections |
Capecitabine | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0093-7474 | TABLET, FILM COATED | 500 mg | ORAL | ANDA | 28 sections |
Capecitabine | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0378-2511 | TABLET, FILM COATED | 150 mg | ORAL | ANDA | 29 sections |
Capecitabine | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0378-2512 | TABLET, FILM COATED | 500 mg | ORAL | ANDA | 29 sections |
CAPECITABINE | HUMAN PRESCRIPTION DRUG LABEL | 1 | 16714-467 | TABLET, FILM COATED | 150 mg | ORAL | ANDA | 27 sections |
CAPECITABINE | HUMAN PRESCRIPTION DRUG LABEL | 1 | 16714-468 | TABLET, FILM COATED | 500 mg | ORAL | ANDA | 27 sections |
CAPECITABINE | HUMAN PRESCRIPTION DRUG LABEL | 1 | 16729-072 | TABLET, FILM COATED | 150 mg | ORAL | ANDA | 28 sections |
CAPECITABINE | HUMAN PRESCRIPTION DRUG LABEL | 1 | 16729-073 | TABLET, FILM COATED | 500 mg | ORAL | ANDA | 28 sections |
Capecitabine | HUMAN PRESCRIPTION DRUG LABEL | 1 | 50268-154 | TABLET | 500 mg | ORAL | ANDA | 21 sections |
Capecitabine | HUMAN PRESCRIPTION DRUG LABEL | 1 | 51079-510 | TABLET, FILM COATED | 500 mg | ORAL | ANDA | 29 sections |
Capecitabine | HUMAN PRESCRIPTION DRUG LABEL | 1 | 51407-095 | TABLET, FILM COATED | 150 mg | ORAL | ANDA | 28 sections |
Capecitabine | HUMAN PRESCRIPTION DRUG LABEL | 1 | 51407-096 | TABLET, FILM COATED | 500 mg | ORAL | ANDA | 28 sections |
Xeloda | HUMAN PRESCRIPTION DRUG LABEL | 1 | 53808-0411 | TABLET, FILM COATED | 500 mg | ORAL | NDA | 24 sections |
Xeloda | HUMAN PRESCRIPTION DRUG LABEL | 1 | 54868-4143 | TABLET, FILM COATED | 150 mg | ORAL | NDA | 30 sections |
Xeloda | HUMAN PRESCRIPTION DRUG LABEL | 1 | 54868-5260 | TABLET, FILM COATED | 500 mg | ORAL | NDA | 30 sections |
capecitabine | HUMAN PRESCRIPTION DRUG LABEL | 1 | 55111-496 | TABLET | 150 mg | ORAL | ANDA | 26 sections |
capecitabine | HUMAN PRESCRIPTION DRUG LABEL | 1 | 55111-497 | TABLET | 500 mg | ORAL | ANDA | 26 sections |
Capecitabine | Human Prescription Drug Label | 1 | 59651-204 | TABLET | 150 mg | ORAL | ANDA | 28 sections |
Capecitabine | Human Prescription Drug Label | 1 | 59651-205 | TABLET | 500 mg | ORAL | ANDA | 28 sections |
Capecitabine | HUMAN PRESCRIPTION DRUG LABEL | 1 | 59923-721 | TABLET, FILM COATED | 150 mg | ORAL | ANDA | 28 sections |
Capecitabine | HUMAN PRESCRIPTION DRUG LABEL | 1 | 59923-722 | TABLET, FILM COATED | 500 mg | ORAL | ANDA | 28 sections |
Capecitabine | HUMAN PRESCRIPTION DRUG LABEL | 1 | 60687-149 | TABLET, FILM COATED | 500 mg | ORAL | ANDA | 27 sections |
Capecitabine | Human Prescription Drug Label | 1 | 62756-238 | TABLET, FILM COATED | 150 mg | ORAL | ANDA | 30 sections |
Capecitabine | Human Prescription Drug Label | 1 | 62756-239 | TABLET, FILM COATED | 500 mg | ORAL | ANDA | 30 sections |