Stem definition | Drug id | CAS RN |
---|---|---|
nucleosides antiviral or antineoplastic agents, cytarabine or azacitidine derivatives | 480 | 154361-50-9 |
None
Property | Value | Reference |
---|---|---|
BDDCS (Biopharmaceutical Drug Disposition Classification System) | 1 | Benet LZ, Broccatelli F, Oprea TI |
S (Water solubility) | 26 mg/mL | Benet LZ, Broccatelli F, Oprea TI |
EoM (Fraction excreted unchanged in urine) | 3 % | Benet LZ, Broccatelli F, Oprea TI |
MRTD (Maximum Recommended Therapeutic Daily Dose) | 171.93 ยตM/kg/day | Contrera JF, Matthews EJ, Kruhlak NL, Benz RD |
BA (Bioavailability) | 99 % | Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H |
Date | Agency | Company | Orphan |
---|---|---|---|
April 30, 1998 | FDA | HOFFMANN LA ROCHE | |
April 16, 2003 | PMDA | CHUGAI PHARMACEUTICAL CO., LTD. |
MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
---|---|---|---|---|---|---|
Palmar-plantar erythrodysaesthesia syndrome | 7616.91 | 13.29 | 2432 | 104802 | 18633 | 56166200 |
Disease progression | 3414.43 | 13.29 | 2251 | 104983 | 102922 | 56081911 |
Diarrhoea | 2381.23 | 13.29 | 4292 | 102942 | 634215 | 55550618 |
Malignant neoplasm progression | 2197.14 | 13.29 | 1497 | 105737 | 72090 | 56112743 |
Metastases to liver | 1503.24 | 13.29 | 761 | 106473 | 20825 | 56164008 |
Metastases to bone | 1243.28 | 13.29 | 648 | 106586 | 18860 | 56165973 |
Breast cancer metastatic | 1203.06 | 13.29 | 588 | 106646 | 14881 | 56169952 |
Death | 1194.89 | 13.29 | 2242 | 104992 | 339184 | 55845649 |
Mucosal inflammation | 1090.11 | 13.29 | 791 | 106443 | 42019 | 56142814 |
Metastases to central nervous system | 752.72 | 13.29 | 396 | 106838 | 11740 | 56173093 |
Rheumatoid arthritis | 711.83 | 13.29 | 3 | 107231 | 382601 | 55802232 |
Metastases to lung | 686.20 | 13.29 | 368 | 106866 | 11350 | 56173483 |
Neuropathy peripheral | 513.03 | 13.29 | 793 | 106441 | 102100 | 56082733 |
Vomiting | 500.77 | 13.29 | 2072 | 105162 | 496156 | 55688677 |
Breast cancer | 498.38 | 13.29 | 537 | 106697 | 48296 | 56136537 |
Neoplasm progression | 477.33 | 13.29 | 433 | 106801 | 31583 | 56153250 |
Neutropenia | 471.04 | 13.29 | 973 | 106261 | 157194 | 56027639 |
Drug ineffective | 438.78 | 13.29 | 674 | 106560 | 918315 | 55266518 |
Dehydration | 432.34 | 13.29 | 942 | 106292 | 157883 | 56026950 |
Metastases to lymph nodes | 414.71 | 13.29 | 226 | 107008 | 7197 | 56177636 |
Skin exfoliation | 361.10 | 13.29 | 397 | 106837 | 36503 | 56148330 |
Joint swelling | 344.86 | 13.29 | 67 | 107167 | 289733 | 55895100 |
Stomatitis | 339.37 | 13.29 | 726 | 106508 | 120084 | 56064749 |
Nausea | 330.13 | 13.29 | 2531 | 104703 | 761647 | 55423186 |
Bone marrow failure | 318.66 | 13.29 | 328 | 106906 | 27958 | 56156875 |
Contraindicated product administered | 317.09 | 13.29 | 8 | 107226 | 186278 | 55998555 |
Systemic lupus erythematosus | 305.50 | 13.29 | 8 | 107226 | 180070 | 56004763 |
Gastrointestinal toxicity | 304.46 | 13.29 | 173 | 107061 | 5983 | 56178850 |
Skin fissures | 302.18 | 13.29 | 202 | 107032 | 9371 | 56175462 |
Neurotoxicity | 299.10 | 13.29 | 245 | 106989 | 15550 | 56169283 |
Myelosuppression | 295.92 | 13.29 | 254 | 106980 | 17201 | 56167632 |
Skin toxicity | 287.64 | 13.29 | 146 | 107088 | 4007 | 56180826 |
Maternal exposure during pregnancy | 283.77 | 13.29 | 20 | 107214 | 189533 | 55995300 |
Arteriospasm coronary | 278.51 | 13.29 | 137 | 107097 | 3510 | 56181323 |
Arthropathy | 275.80 | 13.29 | 30 | 107204 | 200245 | 55984588 |
Metastases to skin | 275.60 | 13.29 | 104 | 107130 | 1354 | 56183479 |
Condition aggravated | 275.02 | 13.29 | 158 | 107076 | 344740 | 55840093 |
Paronychia | 269.92 | 13.29 | 148 | 107086 | 4770 | 56180063 |
Arthralgia | 259.88 | 13.29 | 346 | 106888 | 501323 | 55683510 |
Decreased appetite | 251.39 | 13.29 | 952 | 106282 | 218279 | 55966554 |
Thrombocytopenia | 250.07 | 13.29 | 695 | 106539 | 135529 | 56049304 |
Metastasis | 235.39 | 13.29 | 134 | 107100 | 4650 | 56180183 |
Osteonecrosis of jaw | 230.97 | 13.29 | 301 | 106933 | 33057 | 56151776 |
Completed suicide | 230.58 | 13.29 | 5 | 107229 | 133828 | 56051005 |
Dry skin | 230.19 | 13.29 | 360 | 106874 | 46749 | 56138084 |
Drug hypersensitivity | 222.23 | 13.29 | 124 | 107110 | 275081 | 55909752 |
Glossodynia | 219.96 | 13.29 | 19 | 107215 | 152439 | 56032394 |
Therapeutic product effect decreased | 217.23 | 13.29 | 32 | 107202 | 169420 | 56015413 |
Haematotoxicity | 211.07 | 13.29 | 154 | 107080 | 8229 | 56176604 |
Enteritis | 211.05 | 13.29 | 147 | 107087 | 7296 | 56177537 |
Sinusitis | 195.93 | 13.29 | 66 | 107168 | 197515 | 55987318 |
Exposure during pregnancy | 193.95 | 13.29 | 18 | 107216 | 136324 | 56048509 |
Skin discolouration | 189.75 | 13.29 | 278 | 106956 | 34078 | 56150755 |
Cardiotoxicity | 189.13 | 13.29 | 139 | 107095 | 7511 | 56177322 |
Tumour marker increased | 184.12 | 13.29 | 110 | 107124 | 4183 | 56180650 |
Product use issue | 179.55 | 13.29 | 65 | 107169 | 185976 | 55998857 |
Dihydropyrimidine dehydrogenase deficiency | 175.51 | 13.29 | 39 | 107195 | 45 | 56184788 |
Treatment failure | 174.08 | 13.29 | 54 | 107180 | 170338 | 56014495 |
Laryngospasm | 172.80 | 13.29 | 92 | 107142 | 2792 | 56182041 |
Metastases to peritoneum | 169.28 | 13.29 | 92 | 107142 | 2912 | 56181921 |
Ascites | 167.08 | 13.29 | 275 | 106959 | 37269 | 56147564 |
Fall | 162.03 | 13.29 | 270 | 106964 | 357240 | 55827593 |
Asthenia | 159.89 | 13.29 | 1159 | 106075 | 341814 | 55843019 |
Metastases to pleura | 159.02 | 13.29 | 69 | 107165 | 1313 | 56183520 |
Wound | 158.89 | 13.29 | 35 | 107199 | 138769 | 56046064 |
PIK3CA-activated mutation | 158.43 | 13.29 | 62 | 107172 | 896 | 56183937 |
Pleural effusion | 157.59 | 13.29 | 437 | 106797 | 85043 | 56099790 |
Psoriasis | 157.56 | 13.29 | 4 | 107230 | 92688 | 56092145 |
Therapy cessation | 155.48 | 13.29 | 224 | 107010 | 27040 | 56157793 |
Musculoskeletal stiffness | 153.09 | 13.29 | 53 | 107181 | 155954 | 56028879 |
Swelling | 144.69 | 13.29 | 146 | 107088 | 239625 | 55945208 |
Pseudocirrhosis | 144.31 | 13.29 | 52 | 107182 | 589 | 56184244 |
Weight increased | 144.25 | 13.29 | 135 | 107099 | 229568 | 55955265 |
Osteonecrosis | 141.64 | 13.29 | 197 | 107037 | 23018 | 56161815 |
Metastases to spine | 139.78 | 13.29 | 81 | 107153 | 2908 | 56181925 |
Metastatic neoplasm | 139.19 | 13.29 | 89 | 107145 | 3824 | 56181009 |
Nail disorder | 136.61 | 13.29 | 137 | 107097 | 11314 | 56173519 |
Pericarditis | 136.29 | 13.29 | 22 | 107212 | 108901 | 56075932 |
Pain | 134.85 | 13.29 | 729 | 106505 | 662455 | 55522378 |
Breast cancer recurrent | 131.03 | 13.29 | 87 | 107147 | 3988 | 56180845 |
Hospice care | 130.05 | 13.29 | 102 | 107132 | 6078 | 56178755 |
Infusion related reaction | 125.14 | 13.29 | 128 | 107106 | 208803 | 55976030 |
Hepatic function abnormal | 122.43 | 13.29 | 229 | 107005 | 34329 | 56150504 |
Hepatic lesion | 120.55 | 13.29 | 84 | 107150 | 4171 | 56180662 |
Abdominal discomfort | 120.41 | 13.29 | 215 | 107019 | 277059 | 55907774 |
Discomfort | 120.00 | 13.29 | 60 | 107174 | 141701 | 56043132 |
Lymphangiosis carcinomatosa | 116.99 | 13.29 | 54 | 107180 | 1195 | 56183638 |
Headache | 116.02 | 13.29 | 610 | 106624 | 558434 | 55626399 |
Onycholysis | 114.73 | 13.29 | 55 | 107179 | 1329 | 56183504 |
Irritable bowel syndrome | 109.18 | 13.29 | 5 | 107229 | 68453 | 56116380 |
Ejection fraction decreased | 108.74 | 13.29 | 160 | 107074 | 19681 | 56165152 |
Pruritus | 107.24 | 13.29 | 282 | 106952 | 316341 | 55868492 |
Blood bilirubin increased | 107.09 | 13.29 | 212 | 107022 | 33142 | 56151691 |
Carbohydrate antigen 15-3 increased | 106.86 | 13.29 | 51 | 107183 | 1220 | 56183613 |
Arthritis | 106.79 | 13.29 | 29 | 107205 | 99823 | 56085010 |
Duodenal ulcer perforation | 105.80 | 13.29 | 6 | 107228 | 68336 | 56116497 |
Drug interaction | 101.92 | 13.29 | 151 | 107083 | 209604 | 55975229 |
Lower respiratory tract infection | 101.11 | 13.29 | 46 | 107188 | 114748 | 56070085 |
Jaundice | 94.36 | 13.29 | 179 | 107055 | 27115 | 56157718 |
Enterocolitis | 94.08 | 13.29 | 90 | 107144 | 7014 | 56177819 |
Injection site pain | 94.06 | 13.29 | 53 | 107181 | 117065 | 56067768 |
Bone lesion | 94.02 | 13.29 | 80 | 107154 | 5350 | 56179483 |
Asthma | 92.06 | 13.29 | 50 | 107184 | 112720 | 56072113 |
Intestinal obstruction | 91.26 | 13.29 | 179 | 107055 | 27792 | 56157041 |
Depression | 91.11 | 13.29 | 126 | 107108 | 179991 | 56004842 |
Overdose | 90.75 | 13.29 | 44 | 107190 | 105786 | 56079047 |
Paraesthesia | 90.66 | 13.29 | 489 | 106745 | 130025 | 56054808 |
Fibromyalgia | 89.95 | 13.29 | 6 | 107228 | 59597 | 56125236 |
Carcinoembryonic antigen increased | 89.81 | 13.29 | 49 | 107185 | 1563 | 56183270 |
Pneumonia | 88.39 | 13.29 | 437 | 106797 | 406661 | 55778172 |
Polyneuropathy | 87.58 | 13.29 | 116 | 107118 | 12934 | 56171899 |
Influenza | 87.34 | 13.29 | 36 | 107198 | 95225 | 56089608 |
Hyperbilirubinaemia | 86.31 | 13.29 | 102 | 107132 | 10133 | 56174700 |
Bronchitis | 85.72 | 13.29 | 54 | 107180 | 112257 | 56072576 |
Intentional overdose | 84.65 | 13.29 | 14 | 107220 | 68103 | 56116730 |
Urticaria | 83.92 | 13.29 | 91 | 107143 | 144585 | 56040248 |
Leukopenia | 82.67 | 13.29 | 310 | 106924 | 70630 | 56114203 |
Therapeutic product effect incomplete | 82.28 | 13.29 | 50 | 107184 | 105981 | 56078852 |
Nasopharyngitis | 81.64 | 13.29 | 188 | 107046 | 220771 | 55964062 |
Hypokalaemia | 81.26 | 13.29 | 376 | 106858 | 94061 | 56090772 |
Osteoarthritis | 80.96 | 13.29 | 26 | 107208 | 80270 | 56104563 |
Bradycardia | 79.31 | 13.29 | 16 | 107218 | 67488 | 56117345 |
Non-cirrhotic portal hypertension | 78.31 | 13.29 | 24 | 107210 | 156 | 56184677 |
Mobility decreased | 77.77 | 13.29 | 46 | 107188 | 98945 | 56085888 |
Metastases to meninges | 76.72 | 13.29 | 50 | 107184 | 2220 | 56182613 |
Plasma cell myeloma | 75.73 | 13.29 | 3 | 107231 | 46643 | 56138190 |
Hypersensitivity | 75.38 | 13.29 | 244 | 106990 | 256164 | 55928669 |
Febrile neutropenia | 74.33 | 13.29 | 397 | 106837 | 105148 | 56079685 |
Abdominal lymphadenopathy | 73.78 | 13.29 | 33 | 107201 | 677 | 56184156 |
Metastases to chest wall | 73.48 | 13.29 | 30 | 107204 | 487 | 56184346 |
Bone pain | 72.05 | 13.29 | 235 | 106999 | 49950 | 56134883 |
Ileus | 71.85 | 13.29 | 109 | 107125 | 13773 | 56171060 |
Infusion site coldness | 70.17 | 13.29 | 23 | 107211 | 191 | 56184642 |
Hepatic enzyme increased | 69.81 | 13.29 | 138 | 107096 | 171246 | 56013587 |
Dysaesthesia pharynx | 69.67 | 13.29 | 21 | 107213 | 128 | 56184705 |
Colitis | 68.53 | 13.29 | 205 | 107029 | 41606 | 56143227 |
Alopecia | 68.32 | 13.29 | 307 | 106927 | 293151 | 55891682 |
Suicide attempt | 67.34 | 13.29 | 14 | 107220 | 57822 | 56127011 |
Fingerprint loss | 67.19 | 13.29 | 15 | 107219 | 18 | 56184815 |
Product use in unapproved indication | 65.84 | 13.29 | 104 | 107130 | 140718 | 56044115 |
Metastases to the mediastinum | 65.49 | 13.29 | 27 | 107207 | 450 | 56184383 |
Suicidal ideation | 65.15 | 13.29 | 15 | 107219 | 57727 | 56127106 |
Gastrointestinal perforation | 63.45 | 13.29 | 51 | 107183 | 3148 | 56181685 |
Folliculitis | 62.60 | 13.29 | 14 | 107220 | 54965 | 56129868 |
Bone disorder | 62.46 | 13.29 | 124 | 107110 | 19419 | 56165414 |
Abortion spontaneous | 61.59 | 13.29 | 6 | 107228 | 43747 | 56141086 |
Gamma-glutamyltransferase decreased | 61.11 | 13.29 | 23 | 107211 | 297 | 56184536 |
Portal hypertension | 60.96 | 13.29 | 52 | 107182 | 3489 | 56181344 |
Loss of personal independence in daily activities | 60.88 | 13.29 | 40 | 107194 | 81329 | 56103504 |
Injection site erythema | 59.42 | 13.29 | 37 | 107197 | 77411 | 56107422 |
Drug intolerance | 58.69 | 13.29 | 282 | 106952 | 264536 | 55920297 |
Nail discolouration | 58.66 | 13.29 | 44 | 107190 | 2452 | 56182381 |
Tooth extraction | 58.56 | 13.29 | 81 | 107153 | 9412 | 56175421 |
Therapy change | 57.06 | 13.29 | 61 | 107173 | 5427 | 56179406 |
Hepatic failure | 56.60 | 13.29 | 166 | 107068 | 33320 | 56151513 |
Colorectal cancer metastatic | 56.59 | 13.29 | 29 | 107205 | 812 | 56184021 |
Neoplasm malignant | 56.57 | 13.29 | 145 | 107089 | 26910 | 56157923 |
Platelet count decreased | 56.13 | 13.29 | 371 | 106863 | 106012 | 56078821 |
Colon cancer metastatic | 55.21 | 13.29 | 32 | 107202 | 1149 | 56183684 |
Pulmonary embolism | 54.96 | 13.29 | 371 | 106863 | 106753 | 56078080 |
Product dose omission issue | 53.34 | 13.29 | 205 | 107029 | 204548 | 55980285 |
Insomnia | 52.65 | 13.29 | 188 | 107046 | 191672 | 55993161 |
Erythema | 52.47 | 13.29 | 490 | 106744 | 155449 | 56029384 |
Metastases to adrenals | 51.73 | 13.29 | 26 | 107208 | 698 | 56184135 |
Blood cholesterol increased | 51.23 | 13.29 | 38 | 107196 | 72541 | 56112292 |
Intestinal perforation | 51.08 | 13.29 | 82 | 107152 | 10877 | 56173956 |
Chronic obstructive pulmonary disease | 50.55 | 13.29 | 23 | 107211 | 57392 | 56127441 |
Hypoalbuminaemia | 50.35 | 13.29 | 80 | 107154 | 10519 | 56174314 |
Pericardial effusion | 50.10 | 13.29 | 139 | 107095 | 27036 | 56157797 |
Peripheral sensory neuropathy | 50.05 | 13.29 | 64 | 107170 | 6892 | 56177941 |
Migraine | 49.86 | 13.29 | 55 | 107179 | 86742 | 56098091 |
Feeling abnormal | 49.85 | 13.29 | 113 | 107121 | 133489 | 56051344 |
Somnolence | 49.74 | 13.29 | 153 | 107081 | 163260 | 56021573 |
Intentional product misuse | 49.62 | 13.29 | 18 | 107216 | 51486 | 56133347 |
Wheezing | 49.54 | 13.29 | 42 | 107192 | 74984 | 56109849 |
Device related thrombosis | 48.42 | 13.29 | 33 | 107201 | 1580 | 56183253 |
Jaw operation | 47.95 | 13.29 | 26 | 107208 | 819 | 56184014 |
Superior vena cava syndrome | 47.83 | 13.29 | 24 | 107210 | 642 | 56184191 |
Skin hyperpigmentation | 47.53 | 13.29 | 55 | 107179 | 5342 | 56179491 |
Chronic kidney disease | 47.30 | 13.29 | 11 | 107223 | 42045 | 56142788 |
Blood pressure fluctuation | 46.51 | 13.29 | 10 | 107224 | 40350 | 56144483 |
Neoplasm | 46.23 | 13.29 | 59 | 107175 | 6342 | 56178491 |
Hypotension | 45.99 | 13.29 | 284 | 106950 | 250224 | 55934609 |
Nasal congestion | 45.98 | 13.29 | 25 | 107209 | 56345 | 56128488 |
Abdominal pain | 45.93 | 13.29 | 720 | 106514 | 258085 | 55926748 |
Leukoencephalopathy | 45.34 | 13.29 | 47 | 107187 | 4035 | 56180798 |
Pyogenic granuloma | 45.20 | 13.29 | 18 | 107216 | 273 | 56184560 |
Disseminated intravascular coagulation | 45.04 | 13.29 | 103 | 107131 | 17782 | 56167051 |
Debridement | 44.72 | 13.29 | 28 | 107206 | 1159 | 56183674 |
Adverse event | 44.53 | 13.29 | 25 | 107209 | 55351 | 56129482 |
Lacrimation increased | 44.38 | 13.29 | 104 | 107130 | 18244 | 56166589 |
Lymphoedema | 43.98 | 13.29 | 75 | 107159 | 10455 | 56174378 |
Anastomotic leak | 43.73 | 13.29 | 20 | 107214 | 433 | 56184400 |
Nail infection | 43.49 | 13.29 | 36 | 107198 | 2317 | 56182516 |
Osteoporosis | 42.58 | 13.29 | 23 | 107211 | 52029 | 56132804 |
Osteolysis | 42.20 | 13.29 | 37 | 107197 | 2576 | 56182257 |
Invasive ductal breast carcinoma | 41.74 | 13.29 | 58 | 107176 | 6768 | 56178065 |
Hypoaesthesia | 41.45 | 13.29 | 432 | 106802 | 141059 | 56043774 |
Angina bullosa haemorrhagica | 41.33 | 13.29 | 14 | 107220 | 130 | 56184703 |
Mucosal toxicity | 41.27 | 13.29 | 18 | 107216 | 347 | 56184486 |
Hyperhidrosis | 40.72 | 13.29 | 73 | 107161 | 94015 | 56090818 |
Bone sequestrum | 40.56 | 13.29 | 28 | 107206 | 1369 | 56183464 |
Drug reaction with eosinophilia and systemic symptoms | 40.51 | 13.29 | 5 | 107229 | 30299 | 56154534 |
Recurrent cancer | 40.26 | 13.29 | 31 | 107203 | 1797 | 56183036 |
Oxygen saturation decreased | 40.25 | 13.29 | 55 | 107179 | 79012 | 56105821 |
Therapy partial responder | 40.11 | 13.29 | 61 | 107173 | 7724 | 56177109 |
Performance status decreased | 40.08 | 13.29 | 40 | 107194 | 3283 | 56181550 |
Blood uric acid decreased | 39.59 | 13.29 | 22 | 107212 | 728 | 56184105 |
Contusion | 39.24 | 13.29 | 120 | 107114 | 128310 | 56056523 |
Central nervous system lesion | 39.18 | 13.29 | 69 | 107165 | 9869 | 56174964 |
Mouth ulceration | 39.17 | 13.29 | 135 | 107099 | 29505 | 56155328 |
Wrong technique in product usage process | 39.09 | 13.29 | 32 | 107202 | 58136 | 56126697 |
Cardiac failure congestive | 38.92 | 13.29 | 67 | 107167 | 87653 | 56097180 |
Plantar erythema | 38.89 | 13.29 | 15 | 107219 | 208 | 56184625 |
Malignant ascites | 38.82 | 13.29 | 23 | 107211 | 861 | 56183972 |
Gingival bleeding | 38.46 | 13.29 | 75 | 107159 | 11591 | 56173242 |
Cardiac output decreased | 38.08 | 13.29 | 23 | 107211 | 892 | 56183941 |
Dysaesthesia | 38.03 | 13.29 | 43 | 107191 | 4073 | 56180760 |
Injury | 37.71 | 13.29 | 35 | 107199 | 59816 | 56125017 |
Ear infection | 37.64 | 13.29 | 7 | 107227 | 31288 | 56153545 |
Agitation | 37.44 | 13.29 | 31 | 107203 | 56005 | 56128828 |
Cataract | 37.25 | 13.29 | 26 | 107208 | 51221 | 56133612 |
Metastases to ovary | 36.92 | 13.29 | 17 | 107217 | 374 | 56184459 |
Hyperkalaemia | 36.72 | 13.29 | 26 | 107208 | 50839 | 56133994 |
Cold dysaesthesia | 36.59 | 13.29 | 8 | 107226 | 8 | 56184825 |
Rhabdomyolysis | 36.24 | 13.29 | 16 | 107218 | 40642 | 56144191 |
Periodontitis | 36.18 | 13.29 | 37 | 107197 | 3126 | 56181707 |
Multiple sclerosis | 36.17 | 13.29 | 5 | 107229 | 27797 | 56157036 |
General physical health deterioration | 36.07 | 13.29 | 488 | 106746 | 169522 | 56015311 |
Hiccups | 35.88 | 13.29 | 30 | 107204 | 1958 | 56182875 |
Therapy interrupted | 35.88 | 13.29 | 119 | 107115 | 25506 | 56159327 |
Exposed bone in jaw | 35.68 | 13.29 | 35 | 107199 | 2813 | 56182020 |
Infusion site induration | 35.50 | 13.29 | 22 | 107212 | 894 | 56183939 |
Anxiety | 35.43 | 13.29 | 219 | 107015 | 192953 | 55991880 |
Human epidermal growth factor receptor negative | 34.96 | 13.29 | 9 | 107225 | 27 | 56184806 |
Drug ineffective for unapproved indication | 34.94 | 13.29 | 4 | 107230 | 25689 | 56159144 |
Acute coronary syndrome | 34.92 | 13.29 | 65 | 107169 | 9703 | 56175130 |
Premature delivery | 34.89 | 13.29 | 5 | 107229 | 27055 | 56157778 |
Hypovolaemic shock | 34.88 | 13.29 | 47 | 107187 | 5326 | 56179507 |
Confusional state | 34.64 | 13.29 | 243 | 106991 | 207912 | 55976921 |
Pharyngeal inflammation | 34.54 | 13.29 | 19 | 107215 | 616 | 56184217 |
Proteinuria | 34.51 | 13.29 | 92 | 107142 | 17478 | 56167355 |
Foetal exposure during pregnancy | 34 | 13.29 | 11 | 107223 | 33812 | 56151021 |
Sedation | 33.88 | 13.29 | 12 | 107222 | 34842 | 56149991 |
Type 2 diabetes mellitus | 33.76 | 13.29 | 24 | 107210 | 46838 | 56137995 |
Blood glucose increased | 33.70 | 13.29 | 57 | 107177 | 75094 | 56109739 |
Hydronephrosis | 33.67 | 13.29 | 62 | 107172 | 9180 | 56175653 |
Eosinophil percentage increased | 33.65 | 13.29 | 22 | 107212 | 982 | 56183851 |
Peripheral swelling | 33.46 | 13.29 | 286 | 106948 | 234440 | 55950393 |
Necrotising oesophagitis | 33.28 | 13.29 | 11 | 107223 | 94 | 56184739 |
Blood creatinine decreased | 33.25 | 13.29 | 45 | 107189 | 5121 | 56179712 |
Malignant pleural effusion | 32.74 | 13.29 | 31 | 107203 | 2385 | 56182448 |
Hypophagia | 32.64 | 13.29 | 125 | 107109 | 28751 | 56156082 |
Lymphadenopathy | 32.36 | 13.29 | 143 | 107091 | 35065 | 56149768 |
Granulocyte count decreased | 32.15 | 13.29 | 21 | 107213 | 936 | 56183897 |
Blood pressure systolic increased | 32.03 | 13.29 | 19 | 107215 | 40817 | 56144016 |
Acute kidney injury | 31.84 | 13.29 | 299 | 106935 | 240464 | 55944369 |
Pulmonary arterial hypertension | 31.72 | 13.29 | 6 | 107228 | 26497 | 56158336 |
Subacute cutaneous lupus erythematosus | 31.56 | 13.29 | 30 | 107204 | 2319 | 56182514 |
Prescribed overdose | 31.53 | 13.29 | 3 | 107231 | 22293 | 56162540 |
Urinary tract infection | 31.25 | 13.29 | 300 | 106934 | 240213 | 55944620 |
Constipation | 31.07 | 13.29 | 549 | 106685 | 201394 | 55983439 |
Pregnancy | 31.05 | 13.29 | 12 | 107222 | 33021 | 56151812 |
Early satiety | 30.99 | 13.29 | 20 | 107214 | 873 | 56183960 |
Gastric perforation | 30.97 | 13.29 | 25 | 107209 | 1553 | 56183280 |
Tumour pain | 30.88 | 13.29 | 23 | 107211 | 1268 | 56183565 |
Dysphagia | 30.87 | 13.29 | 264 | 106970 | 81683 | 56103150 |
Radiation necrosis | 30.86 | 13.29 | 15 | 107219 | 374 | 56184459 |
Accidental exposure to product | 30.76 | 13.29 | 5 | 107229 | 24642 | 56160191 |
White blood cell count decreased | 30.67 | 13.29 | 371 | 106863 | 125619 | 56059214 |
Stress cardiomyopathy | 30.47 | 13.29 | 56 | 107178 | 8280 | 56176553 |
Pigmentation disorder | 30.24 | 13.29 | 38 | 107196 | 4021 | 56180812 |
Neutrophil count decreased | 30.15 | 13.29 | 180 | 107054 | 49642 | 56135191 |
Metastases to eye | 29.81 | 13.29 | 11 | 107223 | 134 | 56184699 |
Brachiocephalic vein thrombosis | 29.80 | 13.29 | 10 | 107224 | 90 | 56184743 |
Hormone receptor positive breast cancer | 29.74 | 13.29 | 16 | 107218 | 496 | 56184337 |
Toothache | 29.60 | 13.29 | 88 | 107146 | 17792 | 56167041 |
Breast neoplasm | 29.58 | 13.29 | 23 | 107211 | 1353 | 56183480 |
Device issue | 29.43 | 13.29 | 3 | 107231 | 21103 | 56163730 |
Ejection fraction | 29.14 | 13.29 | 25 | 107209 | 1690 | 56183143 |
Congestive cardiomyopathy | 29.14 | 13.29 | 45 | 107189 | 5774 | 56179059 |
Sopor | 29.10 | 13.29 | 3 | 107231 | 20919 | 56163914 |
Onychomadesis | 28.69 | 13.29 | 40 | 107194 | 4681 | 56180152 |
Biliary sepsis | 28.53 | 13.29 | 19 | 107215 | 875 | 56183958 |
Nodular regenerative hyperplasia | 28.42 | 13.29 | 15 | 107219 | 447 | 56184386 |
Anastomotic fistula | 28.26 | 13.29 | 7 | 107227 | 17 | 56184816 |
Triple negative breast cancer | 28.21 | 13.29 | 12 | 107222 | 217 | 56184616 |
Abnormal behaviour | 27.96 | 13.29 | 3 | 107231 | 20269 | 56164564 |
Recall phenomenon | 27.87 | 13.29 | 16 | 107218 | 564 | 56184269 |
Retroperitoneal neoplasm metastatic | 27.86 | 13.29 | 8 | 107226 | 40 | 56184793 |
Varices oesophageal | 27.86 | 13.29 | 31 | 107203 | 2885 | 56181948 |
Cheilitis | 27.72 | 13.29 | 35 | 107199 | 3722 | 56181111 |
Bone debridement | 27.67 | 13.29 | 12 | 107222 | 228 | 56184605 |
Sequestrectomy | 27.58 | 13.29 | 18 | 107216 | 801 | 56184032 |
Loss of consciousness | 27.48 | 13.29 | 111 | 107123 | 109238 | 56075595 |
Injection site bruising | 27.40 | 13.29 | 20 | 107214 | 38501 | 56146332 |
Cachexia | 27.29 | 13.29 | 40 | 107194 | 4902 | 56179931 |
Foot deformity | 27.25 | 13.29 | 6 | 107228 | 23819 | 56161014 |
Oesophagitis | 27.00 | 13.29 | 73 | 107161 | 13984 | 56170849 |
Pancreatic fistula | 26.97 | 13.29 | 6 | 107228 | 7 | 56184826 |
Oral pigmentation | 26.97 | 13.29 | 6 | 107228 | 7 | 56184826 |
Adnexa uteri mass | 26.92 | 13.29 | 15 | 107219 | 499 | 56184334 |
Neoplasm recurrence | 26.70 | 13.29 | 28 | 107206 | 2436 | 56182397 |
Dermatitis acneiform | 26.69 | 13.29 | 37 | 107197 | 4307 | 56180526 |
Hyperaesthesia | 26.55 | 13.29 | 54 | 107180 | 8603 | 56176230 |
Nervousness | 26.52 | 13.29 | 11 | 107223 | 29004 | 56155829 |
Asthenopia | 26.49 | 13.29 | 26 | 107208 | 2091 | 56182742 |
Hand-foot-and-mouth disease | 26.44 | 13.29 | 10 | 107224 | 131 | 56184702 |
Joint injury | 26.40 | 13.29 | 8 | 107226 | 25646 | 56159187 |
Arterial thrombosis | 26.23 | 13.29 | 21 | 107213 | 1289 | 56183544 |
Brain operation | 26.20 | 13.29 | 15 | 107219 | 526 | 56184307 |
Myocardial infarction | 26.12 | 13.29 | 90 | 107144 | 92780 | 56092053 |
Pulmonary mass | 25.98 | 13.29 | 92 | 107142 | 20378 | 56164455 |
Joint range of motion decreased | 25.94 | 13.29 | 8 | 107226 | 25357 | 56159476 |
Thrombosis | 25.93 | 13.29 | 198 | 107036 | 59229 | 56125604 |
Tooth erosion | 25.93 | 13.29 | 14 | 107220 | 437 | 56184396 |
Pneumatosis intestinalis | 25.32 | 13.29 | 26 | 107208 | 2207 | 56182626 |
Atrial fibrillation | 25.24 | 13.29 | 114 | 107120 | 108783 | 56076050 |
Tumour perforation | 24.97 | 13.29 | 9 | 107225 | 102 | 56184731 |
Ataxia | 24.91 | 13.29 | 72 | 107162 | 14331 | 56170502 |
Steatohepatitis | 24.87 | 13.29 | 14 | 107220 | 475 | 56184358 |
Vascular pain | 24.84 | 13.29 | 16 | 107218 | 696 | 56184137 |
Stridor | 24.79 | 13.29 | 31 | 107203 | 3264 | 56181569 |
Limbal stem cell deficiency | 24.70 | 13.29 | 6 | 107228 | 13 | 56184820 |
Vasodilatation | 24.49 | 13.29 | 26 | 107208 | 2295 | 56182538 |
Treatment noncompliance | 24.45 | 13.29 | 16 | 107218 | 32607 | 56152226 |
Failure to anastomose | 24.39 | 13.29 | 6 | 107228 | 14 | 56184819 |
Incorrect dose administered | 24.36 | 13.29 | 39 | 107195 | 52508 | 56132325 |
Oral pain | 24.32 | 13.29 | 107 | 107127 | 26186 | 56158647 |
Fluid retention | 24.26 | 13.29 | 41 | 107193 | 54037 | 56130796 |
Hypervolaemia | 24.24 | 13.29 | 10 | 107224 | 26448 | 56158385 |
Radiation skin injury | 24.08 | 13.29 | 17 | 107217 | 862 | 56183971 |
Mucosal necrosis | 23.90 | 13.29 | 7 | 107227 | 38 | 56184795 |
Adenocarcinoma | 23.89 | 13.29 | 28 | 107206 | 2757 | 56182076 |
Vessel puncture site bruise | 23.87 | 13.29 | 13 | 107221 | 413 | 56184420 |
Pulmonary hypertension | 23.87 | 13.29 | 20 | 107214 | 35924 | 56148909 |
Epistaxis | 23.72 | 13.29 | 213 | 107021 | 66810 | 56118023 |
No adverse event | 23.69 | 13.29 | 134 | 107100 | 36240 | 56148593 |
Gingivitis | 23.54 | 13.29 | 48 | 107186 | 7661 | 56177172 |
Unresponsive to stimuli | 23.18 | 13.29 | 16 | 107218 | 31709 | 56153124 |
Medication error | 23.04 | 13.29 | 28 | 107206 | 42307 | 56142526 |
Computerised tomogram abnormal | 23.01 | 13.29 | 24 | 107210 | 2075 | 56182758 |
C-reactive protein increased | 22.99 | 13.29 | 75 | 107159 | 78609 | 56106224 |
Schistosomiasis | 22.87 | 13.29 | 5 | 107229 | 5 | 56184828 |
Increased liver stiffness | 22.87 | 13.29 | 5 | 107229 | 5 | 56184828 |
Hepatic atrophy | 22.86 | 13.29 | 11 | 107223 | 268 | 56184565 |
Transaminases | 22.74 | 13.29 | 8 | 107226 | 84 | 56184749 |
Injection site haemorrhage | 22.71 | 13.29 | 7 | 107227 | 22194 | 56162639 |
Hip arthroplasty | 22.70 | 13.29 | 24 | 107210 | 38599 | 56146234 |
Pleural neoplasm | 22.66 | 13.29 | 12 | 107222 | 360 | 56184473 |
Hepatic cancer metastatic | 22.66 | 13.29 | 12 | 107222 | 360 | 56184473 |
Motion sickness | 22.46 | 13.29 | 16 | 107218 | 823 | 56184010 |
Ingrowing nail | 22.39 | 13.29 | 24 | 107210 | 2141 | 56182692 |
Post-traumatic neck syndrome | 22.38 | 13.29 | 23 | 107211 | 1955 | 56182878 |
Dental care | 22.24 | 13.29 | 17 | 107217 | 975 | 56183858 |
Nephrolithiasis | 22.17 | 13.29 | 23 | 107211 | 37312 | 56147521 |
Blood lactate dehydrogenase increased | 22.14 | 13.29 | 88 | 107146 | 20587 | 56164246 |
Metastases to breast | 22.10 | 13.29 | 11 | 107223 | 289 | 56184544 |
Pulpitis dental | 22.10 | 13.29 | 16 | 107218 | 844 | 56183989 |
Nightmare | 21.95 | 13.29 | 3 | 107231 | 16823 | 56168010 |
Cytomegalovirus infection | 21.79 | 13.29 | 5 | 107229 | 19291 | 56165542 |
Vertebral column mass | 21.77 | 13.29 | 9 | 107225 | 151 | 56184682 |
Cholangitis | 21.67 | 13.29 | 36 | 107198 | 4913 | 56179920 |
Respiratory arrest | 21.65 | 13.29 | 16 | 107218 | 30609 | 56154224 |
Diverticulitis | 21.39 | 13.29 | 22 | 107212 | 35830 | 56149003 |
Brain neoplasm | 21.26 | 13.29 | 32 | 107202 | 4014 | 56180819 |
Heart rate increased | 21.25 | 13.29 | 84 | 107150 | 83189 | 56101644 |
Respiratory disorder | 21.22 | 13.29 | 20 | 107214 | 33937 | 56150896 |
Biliary obstruction | 21.21 | 13.29 | 25 | 107209 | 2476 | 56182357 |
Right ventricular failure | 21.18 | 13.29 | 3 | 107231 | 16376 | 56168457 |
Blood pressure increased | 21.06 | 13.29 | 176 | 107058 | 145000 | 56039833 |
Chemotherapy cardiotoxicity attenuation | 21.06 | 13.29 | 4 | 107230 | 0 | 56184833 |
Radiation myelopathy | 21.06 | 13.29 | 4 | 107230 | 0 | 56184833 |
Oral toxicity | 21.06 | 13.29 | 4 | 107230 | 0 | 56184833 |
Neuroendocrine breast tumour | 20.90 | 13.29 | 6 | 107228 | 30 | 56184803 |
Fatigue | 20.80 | 13.29 | 1757 | 105477 | 786795 | 55398038 |
Neutropenic sepsis | 20.80 | 13.29 | 70 | 107164 | 15115 | 56169718 |
Brain oedema | 20.73 | 13.29 | 64 | 107170 | 13207 | 56171626 |
Lactic acidosis | 20.73 | 13.29 | 22 | 107212 | 35324 | 56149509 |
Breast disorder | 20.70 | 13.29 | 24 | 107210 | 2335 | 56182498 |
Caesarean section | 20.68 | 13.29 | 3 | 107231 | 16088 | 56168745 |
Product quality issue | 20.66 | 13.29 | 18 | 107216 | 31718 | 56153115 |
Hyperglycaemic hyperosmolar nonketotic syndrome | 20.64 | 13.29 | 14 | 107220 | 665 | 56184168 |
Disturbance in attention | 20.53 | 13.29 | 19 | 107215 | 32521 | 56152312 |
Muscle swelling | 20.50 | 13.29 | 12 | 107222 | 439 | 56184394 |
Oral disorder | 20.49 | 13.29 | 47 | 107187 | 8128 | 56176705 |
ECG signs of myocardial ischaemia | 20.48 | 13.29 | 7 | 107227 | 67 | 56184766 |
Purulent discharge | 20.48 | 13.29 | 33 | 107201 | 4391 | 56180442 |
Pneumonitis | 20.37 | 13.29 | 116 | 107118 | 31448 | 56153385 |
Lymphadenopathy mediastinal | 20.18 | 13.29 | 25 | 107209 | 2608 | 56182225 |
Mucosal disorder | 20.15 | 13.29 | 22 | 107212 | 2004 | 56182829 |
Metastases to stomach | 20.15 | 13.29 | 9 | 107225 | 184 | 56184649 |
Body temperature decreased | 20.14 | 13.29 | 78 | 107156 | 18030 | 56166803 |
Small intestinal obstruction | 19.98 | 13.29 | 74 | 107160 | 16751 | 56168082 |
Angioedema | 19.94 | 13.29 | 30 | 107204 | 41423 | 56143410 |
Diarrhoea haemorrhagic | 19.90 | 13.29 | 46 | 107188 | 7997 | 56176836 |
Evans syndrome | 19.84 | 13.29 | 9 | 107225 | 191 | 56184642 |
Obesity | 19.74 | 13.29 | 9 | 107225 | 22439 | 56162394 |
Acute respiratory failure | 19.67 | 13.29 | 18 | 107216 | 30976 | 56153857 |
COVID-19 | 19.61 | 13.29 | 75 | 107159 | 74983 | 56109850 |
Injection site swelling | 19.58 | 13.29 | 33 | 107201 | 43545 | 56141288 |
Subileus | 19.49 | 13.29 | 26 | 107208 | 2918 | 56181915 |
Eye pain | 19.47 | 13.29 | 18 | 107216 | 30829 | 56154004 |
Coronary artery disease | 19.41 | 13.29 | 18 | 107216 | 30778 | 56154055 |
Macular degeneration | 19.27 | 13.29 | 6 | 107228 | 18902 | 56165931 |
Skin disorder | 19.21 | 13.29 | 100 | 107134 | 26209 | 56158624 |
Sciatica | 19.16 | 13.29 | 13 | 107221 | 25997 | 56158836 |
Odynophagia | 19.12 | 13.29 | 41 | 107193 | 6777 | 56178056 |
Anaemia | 19.11 | 13.29 | 655 | 106579 | 266856 | 55917977 |
Ankle fracture | 19.03 | 13.29 | 4 | 107230 | 16399 | 56168434 |
Metastases to spleen | 18.84 | 13.29 | 8 | 107226 | 144 | 56184689 |
Procedural pain | 18.81 | 13.29 | 4 | 107230 | 16267 | 56168566 |
Acute myeloid leukaemia | 18.79 | 13.29 | 73 | 107161 | 16899 | 56167934 |
Metastases to thorax | 18.72 | 13.29 | 9 | 107225 | 219 | 56184614 |
Hepatic neoplasm | 18.69 | 13.29 | 20 | 107214 | 1781 | 56183052 |
Femoral artery embolism | 18.61 | 13.29 | 6 | 107228 | 47 | 56184786 |
Depressed level of consciousness | 18.49 | 13.29 | 51 | 107183 | 56382 | 56128451 |
Carcinoid tumour pulmonary | 18.37 | 13.29 | 11 | 107223 | 420 | 56184413 |
Disease recurrence | 18.33 | 13.29 | 92 | 107142 | 23768 | 56161065 |
Radiation fibrosis - lung | 18.32 | 13.29 | 5 | 107229 | 20 | 56184813 |
Myalgia | 18.28 | 13.29 | 162 | 107072 | 131863 | 56052970 |
Dysgeusia | 18.23 | 13.29 | 137 | 107097 | 40778 | 56144055 |
Dyschezia | 18.13 | 13.29 | 21 | 107213 | 2042 | 56182791 |
Chemical peritonitis | 18.09 | 13.29 | 7 | 107227 | 98 | 56184735 |
Dermatomyositis | 17.96 | 13.29 | 24 | 107210 | 2698 | 56182135 |
Pericardial effusion malignant | 17.96 | 13.29 | 7 | 107227 | 100 | 56184733 |
Cognitive disorder | 17.95 | 13.29 | 42 | 107192 | 49091 | 56135742 |
Pelvic fluid collection | 17.95 | 13.29 | 14 | 107220 | 827 | 56184006 |
Hypothalamo-pituitary disorder | 17.94 | 13.29 | 13 | 107221 | 687 | 56184146 |
Sinus congestion | 17.90 | 13.29 | 4 | 107230 | 15720 | 56169113 |
Calcium ionised increased | 17.90 | 13.29 | 7 | 107227 | 101 | 56184732 |
Metastases to abdominal cavity | 17.88 | 13.29 | 11 | 107223 | 441 | 56184392 |
Product prescribing error | 17.88 | 13.29 | 11 | 107223 | 23175 | 56161658 |
Insulinoma | 17.83 | 13.29 | 7 | 107227 | 102 | 56184731 |
Eosinophilia | 17.73 | 13.29 | 8 | 107226 | 20069 | 56164764 |
Respiratory tract congestion | 17.68 | 13.29 | 4 | 107230 | 15587 | 56169246 |
Haematoma | 17.61 | 13.29 | 21 | 107213 | 31998 | 56152835 |
Weight decreased | 17.60 | 13.29 | 591 | 106643 | 240123 | 55944710 |
Peripheral motor neuropathy | 17.51 | 13.29 | 18 | 107216 | 1530 | 56183303 |
Tubulointerstitial nephritis | 17.51 | 13.29 | 5 | 107229 | 16660 | 56168173 |
Sudden death | 17.51 | 13.29 | 49 | 107185 | 9576 | 56175257 |
Delirium | 17.49 | 13.29 | 34 | 107200 | 42483 | 56142350 |
Paraneoplastic dermatomyositis | 17.41 | 13.29 | 4 | 107230 | 6 | 56184827 |
Anaphylactic reaction | 17.39 | 13.29 | 56 | 107178 | 58939 | 56125894 |
Tumour marker abnormal | 17.36 | 13.29 | 10 | 107224 | 355 | 56184478 |
Botryomycosis | 17.25 | 13.29 | 5 | 107229 | 26 | 56184807 |
Brachial plexopathy | 17.24 | 13.29 | 7 | 107227 | 112 | 56184721 |
Enterocolitis haemorrhagic | 17.15 | 13.29 | 17 | 107217 | 1384 | 56183449 |
Mental disorder | 17.12 | 13.29 | 12 | 107222 | 23592 | 56161241 |
Artificial menopause | 17.10 | 13.29 | 5 | 107229 | 27 | 56184806 |
Gait disturbance | 17.09 | 13.29 | 214 | 107020 | 163107 | 56021726 |
Psychotic disorder | 17.05 | 13.29 | 12 | 107222 | 23546 | 56161287 |
Thyroid disorder | 17.01 | 13.29 | 3 | 107231 | 13935 | 56170898 |
Oncologic complication | 17.01 | 13.29 | 8 | 107226 | 185 | 56184648 |
Herpangina | 16.94 | 13.29 | 5 | 107229 | 28 | 56184805 |
Abdominal distension | 16.93 | 13.29 | 224 | 107010 | 77402 | 56107431 |
Prinzmetal angina | 16.89 | 13.29 | 13 | 107221 | 753 | 56184080 |
Wound dehiscence | 16.86 | 13.29 | 31 | 107203 | 4584 | 56180249 |
Anal erythema | 16.85 | 13.29 | 8 | 107226 | 189 | 56184644 |
Bone fistula | 16.81 | 13.29 | 6 | 107228 | 66 | 56184767 |
Neutrophil count abnormal | 16.79 | 13.29 | 23 | 107211 | 2647 | 56182186 |
Gallbladder disorder | 16.79 | 13.29 | 6 | 107228 | 17328 | 56167505 |
Vein disorder | 16.76 | 13.29 | 31 | 107203 | 4606 | 56180227 |
Pulmonary thrombosis | 16.72 | 13.29 | 43 | 107191 | 7994 | 56176839 |
Rectal perforation | 16.67 | 13.29 | 10 | 107224 | 383 | 56184450 |
Dermatitis | 16.63 | 13.29 | 65 | 107169 | 15092 | 56169741 |
Inappropriate schedule of product administration | 16.62 | 13.29 | 92 | 107142 | 83295 | 56101538 |
Hyperammonaemia | 16.58 | 13.29 | 32 | 107202 | 4908 | 56179925 |
Tongue discolouration | 16.53 | 13.29 | 24 | 107210 | 2915 | 56181918 |
Anastomotic complication | 16.49 | 13.29 | 7 | 107227 | 126 | 56184707 |
Premature baby | 16.43 | 13.29 | 8 | 107226 | 19197 | 56165636 |
Jaundice cholestatic | 16.42 | 13.29 | 34 | 107200 | 5485 | 56179348 |
Gastrointestinal inflammation | 16.41 | 13.29 | 32 | 107202 | 4946 | 56179887 |
Bursitis | 16.37 | 13.29 | 17 | 107217 | 27565 | 56157268 |
Carbohydrate antigen 19-9 increased | 16.26 | 13.29 | 8 | 107226 | 205 | 56184628 |
Excessive granulation tissue | 16.25 | 13.29 | 13 | 107221 | 797 | 56184036 |
Disability | 16.09 | 13.29 | 5 | 107229 | 15775 | 56169058 |
Radioisotope scan | 16.07 | 13.29 | 4 | 107230 | 10 | 56184823 |
Impaired work ability | 16.01 | 13.29 | 4 | 107230 | 14568 | 56170265 |
Small intestinal perforation | 16.01 | 13.29 | 16 | 107218 | 1315 | 56183518 |
Metastases to muscle | 16.00 | 13.29 | 7 | 107227 | 136 | 56184697 |
Tumour invasion | 15.90 | 13.29 | 7 | 107227 | 138 | 56184695 |
Hypermutation | 15.87 | 13.29 | 5 | 107229 | 36 | 56184797 |
Hyperglycaemia | 15.84 | 13.29 | 126 | 107108 | 38155 | 56146678 |
Metastases to thyroid | 15.80 | 13.29 | 3 | 107231 | 0 | 56184833 |
Hyperchylomicronaemia | 15.80 | 13.29 | 3 | 107231 | 0 | 56184833 |
Radiotherapy | 15.76 | 13.29 | 9 | 107225 | 314 | 56184519 |
Hyperbaric oxygen therapy | 15.76 | 13.29 | 5 | 107229 | 37 | 56184796 |
Drug level increased | 15.75 | 13.29 | 10 | 107224 | 20715 | 56164118 |
Blood creatine phosphokinase increased | 15.73 | 13.29 | 18 | 107216 | 27934 | 56156899 |
Upper respiratory tract infection | 15.70 | 13.29 | 76 | 107158 | 71212 | 56113621 |
Colitis ulcerative | 15.67 | 13.29 | 14 | 107220 | 24377 | 56160456 |
Bone cancer metastatic | 15.59 | 13.29 | 7 | 107227 | 145 | 56184688 |
Staphylococcal infection | 15.55 | 13.29 | 30 | 107204 | 37588 | 56147245 |
Catheter site bruise | 15.48 | 13.29 | 9 | 107225 | 325 | 56184508 |
Hepatic cancer | 15.43 | 13.29 | 28 | 107206 | 4099 | 56180734 |
Hallucination, visual | 15.37 | 13.29 | 7 | 107227 | 17461 | 56167372 |
Pituitary tumour | 15.32 | 13.29 | 13 | 107221 | 866 | 56183967 |
Liver scan abnormal | 15.31 | 13.29 | 5 | 107229 | 41 | 56184792 |
Renal vein thrombosis | 15.31 | 13.29 | 9 | 107225 | 332 | 56184501 |
Large intestine perforation | 15.31 | 13.29 | 41 | 107193 | 7810 | 56177023 |
Perforation | 15.29 | 13.29 | 14 | 107220 | 1032 | 56183801 |
Vulval disorder | 15.25 | 13.29 | 12 | 107222 | 718 | 56184115 |
Hypertriglyceridaemia | 15.21 | 13.29 | 34 | 107200 | 5782 | 56179051 |
Obstruction gastric | 15.17 | 13.29 | 13 | 107221 | 878 | 56183955 |
Ileus paralytic | 15.10 | 13.29 | 28 | 107206 | 4167 | 56180666 |
Gram stain positive | 15.10 | 13.29 | 5 | 107229 | 43 | 56184790 |
Restlessness | 15.09 | 13.29 | 17 | 107217 | 26569 | 56158264 |
Radiation injury | 15.01 | 13.29 | 10 | 107224 | 461 | 56184372 |
Abdominal symptom | 15.00 | 13.29 | 9 | 107225 | 345 | 56184488 |
Oestrogen receptor assay positive | 14.95 | 13.29 | 10 | 107224 | 464 | 56184369 |
Infection | 14.91 | 13.29 | 280 | 106954 | 199926 | 55984907 |
Rhinorrhoea | 14.89 | 13.29 | 57 | 107177 | 56980 | 56127853 |
Colon cancer | 14.84 | 13.29 | 46 | 107188 | 9515 | 56175318 |
Myopathy toxic | 14.80 | 13.29 | 10 | 107224 | 472 | 56184361 |
Paresis | 14.76 | 13.29 | 20 | 107214 | 2278 | 56182555 |
Facial asymmetry | 14.73 | 13.29 | 12 | 107222 | 755 | 56184078 |
Lip pain | 14.70 | 13.29 | 17 | 107217 | 1650 | 56183183 |
Mediastinal disorder | 14.67 | 13.29 | 9 | 107225 | 359 | 56184474 |
Influenza like illness | 14.64 | 13.29 | 63 | 107171 | 60925 | 56123908 |
Restless legs syndrome | 14.59 | 13.29 | 7 | 107227 | 16940 | 56167893 |
Musculoskeletal chest pain | 14.58 | 13.29 | 75 | 107159 | 19566 | 56165267 |
Hospitalisation | 14.56 | 13.29 | 212 | 107022 | 74788 | 56110045 |
Torsade de pointes | 14.50 | 13.29 | 3 | 107231 | 12437 | 56172396 |
Corneal erosion | 14.47 | 13.29 | 8 | 107226 | 262 | 56184571 |
Renal hydrocele | 14.46 | 13.29 | 4 | 107230 | 17 | 56184816 |
Venous thrombosis limb | 14.46 | 13.29 | 22 | 107212 | 2787 | 56182046 |
Inflammation | 14.43 | 13.29 | 75 | 107159 | 68996 | 56115837 |
Kidney infection | 14.43 | 13.29 | 11 | 107223 | 20714 | 56164119 |
Joint dislocation | 14.38 | 13.29 | 6 | 107228 | 15767 | 56169066 |
Wound treatment | 14.38 | 13.29 | 7 | 107227 | 175 | 56184658 |
Extrapyramidal disorder | 14.36 | 13.29 | 3 | 107231 | 12353 | 56172480 |
Pulmonary hilum mass | 14.34 | 13.29 | 6 | 107228 | 104 | 56184729 |
Ureteric obstruction | 14.33 | 13.29 | 17 | 107217 | 1695 | 56183138 |
Tumour excision | 14.32 | 13.29 | 9 | 107225 | 375 | 56184458 |
Tenderness | 14.30 | 13.29 | 76 | 107158 | 20079 | 56164754 |
Mood swings | 14.29 | 13.29 | 7 | 107227 | 16740 | 56168093 |
Hallucination | 14.25 | 13.29 | 47 | 107187 | 49102 | 56135731 |
Diabetes mellitus | 14.23 | 13.29 | 52 | 107182 | 52683 | 56132150 |
Gastroenteropancreatic neuroendocrine tumour disease | 14.17 | 13.29 | 5 | 107229 | 53 | 56184780 |
Crying | 14.15 | 13.29 | 12 | 107222 | 21428 | 56163405 |
Fistula | 14.11 | 13.29 | 43 | 107191 | 8812 | 56176021 |
Peritoneal fluid analysis abnormal | 14.10 | 13.29 | 4 | 107230 | 19 | 56184814 |
Metastases to pelvis | 14.07 | 13.29 | 9 | 107225 | 387 | 56184446 |
Accidental overdose | 14.07 | 13.29 | 11 | 107223 | 20450 | 56164383 |
Metastases to bladder | 14.06 | 13.29 | 7 | 107227 | 184 | 56184649 |
Limb injury | 14.05 | 13.29 | 13 | 107221 | 22257 | 56162576 |
Activated PI3 kinase delta syndrome | 13.93 | 13.29 | 4 | 107230 | 20 | 56184813 |
Pneumoperitoneum | 13.92 | 13.29 | 15 | 107219 | 1346 | 56183487 |
Bile duct stenosis | 13.92 | 13.29 | 14 | 107220 | 1160 | 56183673 |
Lymphangitis | 13.85 | 13.29 | 12 | 107222 | 822 | 56184011 |
Hypoglycaemia | 13.80 | 13.29 | 57 | 107177 | 55758 | 56129075 |
Sputum discoloured | 13.75 | 13.29 | 5 | 107229 | 14287 | 56170546 |
Actinomycosis | 13.73 | 13.29 | 13 | 107221 | 1000 | 56183833 |
Metastases to kidney | 13.72 | 13.29 | 7 | 107227 | 194 | 56184639 |
Anxiety disorder due to a general medical condition | 13.72 | 13.29 | 3 | 107231 | 3 | 56184830 |
Abdominal wall mass | 13.72 | 13.29 | 3 | 107231 | 3 | 56184830 |
Dark circles under eyes | 13.71 | 13.29 | 10 | 107224 | 534 | 56184299 |
Aggression | 13.70 | 13.29 | 13 | 107221 | 21993 | 56162840 |
Paraneoplastic syndrome | 13.69 | 13.29 | 10 | 107224 | 535 | 56184298 |
Tremor | 13.68 | 13.29 | 156 | 107078 | 120933 | 56063900 |
Hypothyroidism | 13.68 | 13.29 | 33 | 107201 | 38163 | 56146670 |
Glaucoma | 13.68 | 13.29 | 8 | 107226 | 17321 | 56167512 |
Irritability | 13.67 | 13.29 | 22 | 107212 | 29566 | 56155267 |
Onychalgia | 13.67 | 13.29 | 12 | 107222 | 837 | 56183996 |
Obstructive airways disorder | 13.61 | 13.29 | 8 | 107226 | 17274 | 56167559 |
Colitis ischaemic | 13.55 | 13.29 | 46 | 107188 | 9974 | 56174859 |
Intracranial pressure increased | 13.52 | 13.29 | 28 | 107206 | 4517 | 56180316 |
Gingival swelling | 13.51 | 13.29 | 26 | 107208 | 3980 | 56180853 |
Heavy menstrual bleeding | 13.49 | 13.29 | 7 | 107227 | 16202 | 56168631 |
Hypercalcaemia of malignancy | 13.47 | 13.29 | 7 | 107227 | 202 | 56184631 |
Stress | 13.45 | 13.29 | 62 | 107172 | 58848 | 56125985 |
Subclavian vein thrombosis | 13.41 | 13.29 | 17 | 107217 | 1815 | 56183018 |
Herpes zoster | 13.40 | 13.29 | 87 | 107147 | 75802 | 56109031 |
Product complaint | 13.37 | 13.29 | 3 | 107231 | 11757 | 56173076 |
MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
---|---|---|---|---|---|---|
Palmar-plantar erythrodysaesthesia syndrome | 2382.10 | 14.62 | 905 | 49909 | 14578 | 31631952 |
Diarrhoea | 1378.53 | 14.62 | 2197 | 48617 | 350212 | 31296318 |
Disease progression | 1145.99 | 14.62 | 1032 | 49782 | 89432 | 31557098 |
Death | 580.54 | 14.62 | 1564 | 49250 | 359005 | 31287525 |
Arteriospasm coronary | 404.46 | 14.62 | 158 | 50656 | 2733 | 31643797 |
Mucosal inflammation | 390.18 | 14.62 | 370 | 50444 | 34057 | 31612473 |
Neuropathy peripheral | 374.59 | 14.62 | 530 | 50284 | 75119 | 31571411 |
Vomiting | 254.50 | 14.62 | 862 | 49952 | 223111 | 31423419 |
Dehydration | 252.38 | 14.62 | 576 | 50238 | 118535 | 31527995 |
Anastomotic leak | 233.35 | 14.62 | 71 | 50743 | 547 | 31645983 |
Stomatitis | 227.79 | 14.62 | 298 | 50516 | 39140 | 31607390 |
Nausea | 224.05 | 14.62 | 1030 | 49784 | 306917 | 31339613 |
Enteritis | 210.44 | 14.62 | 135 | 50679 | 6964 | 31639566 |
Metastases to liver | 208.93 | 14.62 | 169 | 50645 | 12558 | 31633972 |
Neurotoxicity | 186.73 | 14.62 | 176 | 50638 | 16050 | 31630480 |
Gastrointestinal perforation | 181.76 | 14.62 | 97 | 50717 | 3535 | 31642995 |
Malignant neoplasm progression | 172.62 | 14.62 | 387 | 50427 | 78611 | 31567919 |
Intestinal obstruction | 160.10 | 14.62 | 181 | 50633 | 20429 | 31626101 |
Metastases to lung | 157.97 | 14.62 | 121 | 50693 | 8301 | 31638229 |
Dihydropyrimidine dehydrogenase deficiency | 156.29 | 14.62 | 34 | 50780 | 45 | 31646485 |
Decreased appetite | 151.46 | 14.62 | 564 | 50250 | 152653 | 31493877 |
Myelosuppression | 147.64 | 14.62 | 149 | 50665 | 14771 | 31631759 |
Gastrointestinal toxicity | 143.50 | 14.62 | 71 | 50743 | 2203 | 31644327 |
Drug ineffective | 141.93 | 14.62 | 262 | 50552 | 395311 | 31251219 |
Skin toxicity | 140.64 | 14.62 | 86 | 50728 | 4073 | 31642457 |
Bone marrow failure | 139.45 | 14.62 | 197 | 50617 | 27811 | 31618719 |
Completed suicide | 132.24 | 14.62 | 3 | 50811 | 91511 | 31555019 |
Anastomotic complication | 124.34 | 14.62 | 39 | 50775 | 336 | 31646194 |
Colon cancer metastatic | 123.93 | 14.62 | 58 | 50756 | 1587 | 31644943 |
Enterocolitis | 107.69 | 14.62 | 91 | 50723 | 7183 | 31639347 |
Ileus | 100.80 | 14.62 | 123 | 50691 | 15046 | 31631484 |
Neutropenia | 97.38 | 14.62 | 464 | 50350 | 139900 | 31506630 |
Abdominal pain | 97.33 | 14.62 | 477 | 50337 | 145475 | 31501055 |
Pancreatic neuroendocrine tumour metastatic | 96.93 | 14.62 | 28 | 50786 | 176 | 31646354 |
Headache | 94.64 | 14.62 | 93 | 50721 | 183559 | 31462971 |
Arthralgia | 91.10 | 14.62 | 66 | 50748 | 151358 | 31495172 |
Therapy cessation | 85.66 | 14.62 | 113 | 50701 | 14942 | 31631588 |
Condition aggravated | 84.54 | 14.62 | 83 | 50731 | 163926 | 31482604 |
Pneumonia | 80.27 | 14.62 | 273 | 50541 | 335039 | 31311491 |
Metastases to peritoneum | 76.55 | 14.62 | 42 | 50772 | 1618 | 31644912 |
Cardiac failure congestive | 72.25 | 14.62 | 19 | 50795 | 79368 | 31567162 |
Carcinoembryonic antigen increased | 71.94 | 14.62 | 30 | 50784 | 618 | 31645912 |
Tumour perforation | 71.62 | 14.62 | 24 | 50790 | 260 | 31646270 |
Intestinal perforation | 70.85 | 14.62 | 77 | 50737 | 8312 | 31638218 |
Cardiotoxicity | 70.56 | 14.62 | 61 | 50753 | 4966 | 31641564 |
Overdose | 70.27 | 14.62 | 24 | 50790 | 84640 | 31561890 |
Gastrointestinal anastomotic leak | 69.00 | 14.62 | 25 | 50789 | 347 | 31646183 |
Wound dehiscence | 67.59 | 14.62 | 49 | 50765 | 3089 | 31643441 |
Necrotising fasciitis | 65.17 | 14.62 | 50 | 50764 | 3436 | 31643094 |
Fall | 64.89 | 14.62 | 125 | 50689 | 185964 | 31460566 |
Proteus infection | 64.26 | 14.62 | 31 | 50783 | 909 | 31645621 |
Thrombocytopenia | 64.24 | 14.62 | 420 | 50394 | 142327 | 31504203 |
Skin exfoliation | 63.68 | 14.62 | 127 | 50687 | 23747 | 31622783 |
Drug interaction | 62.84 | 14.62 | 152 | 50662 | 208391 | 31438139 |
Dysphagia | 61.60 | 14.62 | 218 | 50596 | 57458 | 31589072 |
Haematotoxicity | 61.13 | 14.62 | 66 | 50748 | 7071 | 31639459 |
Stomal varices | 60.84 | 14.62 | 15 | 50799 | 45 | 31646485 |
Neoplasm progression | 59.14 | 14.62 | 112 | 50702 | 20160 | 31626370 |
Depression | 56.66 | 14.62 | 38 | 50776 | 90777 | 31555753 |
Product dose omission issue | 56.03 | 14.62 | 52 | 50762 | 105534 | 31540996 |
Colon cancer | 55.85 | 14.62 | 69 | 50745 | 8544 | 31637986 |
Recall phenomenon | 55.60 | 14.62 | 24 | 50790 | 540 | 31645990 |
Fingerprint loss | 54.89 | 14.62 | 13 | 50801 | 31 | 31646499 |
Gastric perforation | 53.48 | 14.62 | 38 | 50776 | 2321 | 31644209 |
Anxiety | 52.99 | 14.62 | 41 | 50773 | 90992 | 31555538 |
Portal hypertension | 51.87 | 14.62 | 45 | 50769 | 3680 | 31642850 |
Metastatic gastric cancer | 51.86 | 14.62 | 17 | 50797 | 171 | 31646359 |
Proteinuria | 50.62 | 14.62 | 94 | 50720 | 16669 | 31629861 |
Rectal perforation | 50.43 | 14.62 | 21 | 50793 | 431 | 31646099 |
Peritonitis | 50.16 | 14.62 | 89 | 50725 | 15238 | 31631292 |
Focal nodular hyperplasia | 50.10 | 14.62 | 16 | 50798 | 147 | 31646383 |
Subileus | 49.67 | 14.62 | 40 | 50774 | 2950 | 31643580 |
Rectal cancer | 48.85 | 14.62 | 35 | 50779 | 2166 | 31644364 |
Metastases to lymph nodes | 48.51 | 14.62 | 46 | 50768 | 4222 | 31642308 |
Hyperammonaemic encephalopathy | 48.49 | 14.62 | 35 | 50779 | 2191 | 31644339 |
Colitis | 47.88 | 14.62 | 141 | 50673 | 33746 | 31612784 |
Paraesthesia | 47.58 | 14.62 | 197 | 50617 | 55874 | 31590656 |
Splenorenal shunt | 47.46 | 14.62 | 10 | 50804 | 10 | 31646520 |
Induration | 47.34 | 14.62 | 25 | 50789 | 891 | 31645639 |
Psoriasis | 46.87 | 14.62 | 9 | 50805 | 46710 | 31599820 |
Pulmonary embolism | 46.11 | 14.62 | 255 | 50559 | 81391 | 31565139 |
Hiccups | 45.71 | 14.62 | 65 | 50749 | 9222 | 31637308 |
Dermatitis acneiform | 45.36 | 14.62 | 51 | 50763 | 5716 | 31640814 |
Faecal volume decreased | 45.22 | 14.62 | 14 | 50800 | 115 | 31646415 |
Foetal exposure during pregnancy | 45.22 | 14.62 | 6 | 50808 | 40870 | 31605660 |
Obstruction gastric | 45.13 | 14.62 | 24 | 50790 | 868 | 31645662 |
Vascular pain | 44.49 | 14.62 | 14 | 50800 | 122 | 31646408 |
Cough | 44.01 | 14.62 | 94 | 50720 | 134720 | 31511810 |
Hypovolaemic shock | 43.90 | 14.62 | 53 | 50761 | 6409 | 31640121 |
No adverse event | 43.72 | 14.62 | 97 | 50717 | 19528 | 31627002 |
Colorectal cancer metastatic | 43.59 | 14.62 | 26 | 50788 | 1176 | 31645354 |
Toxic leukoencephalopathy | 43.50 | 14.62 | 17 | 50797 | 294 | 31646236 |
Non-cirrhotic portal hypertension | 42.43 | 14.62 | 16 | 50798 | 250 | 31646280 |
Prothrombin level decreased | 40.77 | 14.62 | 24 | 50790 | 1059 | 31645471 |
Hallucination | 40.54 | 14.62 | 12 | 50802 | 46398 | 31600132 |
Aggression | 40.02 | 14.62 | 6 | 50808 | 37285 | 31609245 |
Metastases to central nervous system | 39.90 | 14.62 | 55 | 50759 | 7581 | 31638949 |
Portal shunt | 39.61 | 14.62 | 10 | 50804 | 34 | 31646496 |
Influenza | 39.57 | 14.62 | 11 | 50803 | 44314 | 31602216 |
Rectal cancer metastatic | 39.51 | 14.62 | 15 | 50799 | 239 | 31646291 |
Confusional state | 39.46 | 14.62 | 98 | 50716 | 133236 | 31513294 |
Tumour marker increased | 39.32 | 14.62 | 19 | 50795 | 559 | 31645971 |
Weight increased | 39.29 | 14.62 | 45 | 50769 | 82902 | 31563628 |
Device occlusion | 39.28 | 14.62 | 48 | 50766 | 5877 | 31640653 |
Intentional product misuse | 38.73 | 14.62 | 7 | 50807 | 37944 | 31608586 |
Terminal ileitis | 38.70 | 14.62 | 13 | 50801 | 142 | 31646388 |
Diaphragmatic spasm | 38.50 | 14.62 | 12 | 50802 | 101 | 31646429 |
Skin fissures | 38.38 | 14.62 | 41 | 50773 | 4339 | 31642191 |
Mucosal disorder | 37.78 | 14.62 | 26 | 50788 | 1508 | 31645022 |
Hypokalaemia | 37.69 | 14.62 | 178 | 50636 | 53396 | 31593134 |
Small intestinal obstruction | 37.53 | 14.62 | 73 | 50741 | 13399 | 31633131 |
Agitation | 37.52 | 14.62 | 20 | 50794 | 54149 | 31592381 |
Clostridial infection | 37.29 | 14.62 | 36 | 50778 | 3379 | 31643151 |
Large intestine perforation | 36.93 | 14.62 | 53 | 50761 | 7583 | 31638947 |
Anal erythema | 36.58 | 14.62 | 11 | 50803 | 81 | 31646449 |
Laryngospasm | 36.47 | 14.62 | 24 | 50790 | 1292 | 31645238 |
Hepatic lesion | 36.40 | 14.62 | 35 | 50779 | 3268 | 31643262 |
Oesophageal haemorrhage | 35.60 | 14.62 | 23 | 50791 | 1200 | 31645330 |
Musculoskeletal stiffness | 35.53 | 14.62 | 11 | 50803 | 41314 | 31605216 |
Metastasis | 35.48 | 14.62 | 36 | 50778 | 3588 | 31642942 |
Asthma | 35.47 | 14.62 | 12 | 50802 | 42599 | 31603931 |
COVID-19 | 35.46 | 14.62 | 22 | 50792 | 54799 | 31591731 |
Rhabdomyolysis | 35.29 | 14.62 | 30 | 50784 | 63551 | 31582979 |
Dizziness | 35.16 | 14.62 | 182 | 50632 | 198965 | 31447565 |
Protein urine | 34.75 | 14.62 | 20 | 50794 | 846 | 31645684 |
Insomnia | 34.50 | 14.62 | 62 | 50752 | 94774 | 31551756 |
Suicidal ideation | 34.49 | 14.62 | 8 | 50806 | 36398 | 31610132 |
Large intestinal obstruction | 34.25 | 14.62 | 24 | 50790 | 1433 | 31645097 |
Prostate cancer | 34.19 | 14.62 | 9 | 50805 | 37592 | 31608938 |
Rectal tenesmus | 34.09 | 14.62 | 19 | 50795 | 755 | 31645775 |
Joint swelling | 33.79 | 14.62 | 22 | 50792 | 53409 | 31593121 |
Pruritus | 33.25 | 14.62 | 97 | 50717 | 125070 | 31521460 |
Polyneuropathy | 33.20 | 14.62 | 68 | 50746 | 12954 | 31633576 |
Intestinal dilatation | 33.13 | 14.62 | 21 | 50793 | 1060 | 31645470 |
Colon cancer recurrent | 32.92 | 14.62 | 11 | 50803 | 118 | 31646412 |
Therapy interrupted | 32.72 | 14.62 | 60 | 50754 | 10536 | 31635994 |
Anal prolapse | 32.63 | 14.62 | 6 | 50808 | 0 | 31646530 |
Biliary obstruction | 32.48 | 14.62 | 29 | 50785 | 2464 | 31644066 |
Bradycardia | 32.41 | 14.62 | 38 | 50776 | 69289 | 31577241 |
Skin discolouration | 32.35 | 14.62 | 77 | 50737 | 16230 | 31630300 |
Neutropenic sepsis | 31.98 | 14.62 | 65 | 50749 | 12314 | 31634216 |
Dysaesthesia pharynx | 31.95 | 14.62 | 9 | 50805 | 51 | 31646479 |
Stoma site haemorrhage | 31.43 | 14.62 | 18 | 50796 | 754 | 31645776 |
Electrocardiogram QT prolonged | 31.10 | 14.62 | 11 | 50803 | 37976 | 31608554 |
Oesophagitis | 30.67 | 14.62 | 64 | 50750 | 12352 | 31634178 |
Peripheral ischaemia | 30.48 | 14.62 | 40 | 50774 | 5260 | 31641270 |
Hospice care | 30.40 | 14.62 | 41 | 50773 | 5535 | 31640995 |
Asthenia | 30.23 | 14.62 | 517 | 50297 | 224238 | 31422292 |
Ascites | 30.12 | 14.62 | 138 | 50676 | 40875 | 31605655 |
Electrocardiogram ST segment elevation | 29.74 | 14.62 | 37 | 50777 | 4614 | 31641916 |
Sinusitis | 29.41 | 14.62 | 11 | 50803 | 36685 | 31609845 |
Erythema | 28.78 | 14.62 | 224 | 50590 | 80181 | 31566349 |
Hyperbilirubinaemia | 28.72 | 14.62 | 72 | 50742 | 15678 | 31630852 |
Gastrointestinal disorder | 28.61 | 14.62 | 111 | 50703 | 30549 | 31615981 |
Tenderness | 28.45 | 14.62 | 41 | 50773 | 5887 | 31640643 |
Inappropriate schedule of product administration | 28.17 | 14.62 | 24 | 50790 | 50799 | 31595731 |
Chronic obstructive pulmonary disease | 28.02 | 14.62 | 19 | 50795 | 45147 | 31601383 |
Abnormal behaviour | 27.58 | 14.62 | 3 | 50811 | 23825 | 31622705 |
Arterial thrombosis | 27.37 | 14.62 | 21 | 50793 | 1443 | 31645087 |
Proctalgia | 27.12 | 14.62 | 35 | 50779 | 4527 | 31642003 |
Disseminated intravascular coagulation | 26.70 | 14.62 | 83 | 50731 | 20454 | 31626076 |
Product use issue | 26.65 | 14.62 | 31 | 50783 | 56728 | 31589802 |
Gastroenteritis radiation | 26.60 | 14.62 | 12 | 50802 | 301 | 31646229 |
Hypoaesthesia | 26.46 | 14.62 | 167 | 50647 | 55855 | 31590675 |
Therapy change | 26.44 | 14.62 | 27 | 50787 | 2711 | 31643819 |
Pelvic abscess | 26.29 | 14.62 | 17 | 50797 | 888 | 31645642 |
Gastric dilatation | 26.11 | 14.62 | 15 | 50799 | 632 | 31645898 |
Seizure | 25.99 | 14.62 | 78 | 50736 | 99690 | 31546840 |
Feeling abnormal | 25.84 | 14.62 | 32 | 50782 | 56970 | 31589560 |
Pigmentation disorder | 25.82 | 14.62 | 24 | 50790 | 2148 | 31644382 |
Injection site pain | 25.16 | 14.62 | 12 | 50802 | 34622 | 31611908 |
Peripheral sensorimotor neuropathy | 25.15 | 14.62 | 20 | 50794 | 1448 | 31645082 |
Myalgia | 25.08 | 14.62 | 54 | 50760 | 77204 | 31569326 |
Leukoencephalopathy | 24.88 | 14.62 | 31 | 50783 | 3871 | 31642659 |
Bronchitis | 24.40 | 14.62 | 16 | 50798 | 38701 | 31607829 |
Wound infection | 24.35 | 14.62 | 40 | 50774 | 6435 | 31640095 |
Gastrointestinal stoma necrosis | 24.34 | 14.62 | 6 | 50808 | 18 | 31646512 |
Nasopharyngitis | 24.22 | 14.62 | 40 | 50774 | 63205 | 31583325 |
Gastrointestinal stoma complication | 24.20 | 14.62 | 18 | 50796 | 1180 | 31645350 |
Temperature intolerance | 24.11 | 14.62 | 27 | 50787 | 3012 | 31643518 |
Hyperfibrinolysis | 24.09 | 14.62 | 6 | 50808 | 19 | 31646511 |
Arthritis | 24.06 | 14.62 | 7 | 50807 | 27378 | 31619152 |
Drug reaction with eosinophilia and systemic symptoms | 24.05 | 14.62 | 9 | 50805 | 30009 | 31616521 |
Cellulitis | 23.89 | 14.62 | 25 | 50789 | 47993 | 31598537 |
Wheezing | 23.88 | 14.62 | 14 | 50800 | 35972 | 31610558 |
Pancreatitis viral | 23.73 | 14.62 | 5 | 50809 | 5 | 31646525 |
Gastric cancer | 23.62 | 14.62 | 38 | 50776 | 6007 | 31640523 |
Blood pressure fluctuation | 23.62 | 14.62 | 4 | 50810 | 22732 | 31623798 |
Fatigue | 23.52 | 14.62 | 703 | 50111 | 334503 | 31312027 |
Performance status decreased | 23.44 | 14.62 | 30 | 50784 | 3848 | 31642682 |
Ventricular fibrillation | 23.42 | 14.62 | 75 | 50739 | 18773 | 31627757 |
Colostomy | 23.05 | 14.62 | 12 | 50802 | 415 | 31646115 |
Dyspnoea | 23.02 | 14.62 | 400 | 50414 | 343079 | 31303451 |
Therapeutic product effect decreased | 22.90 | 14.62 | 11 | 50803 | 31611 | 31614919 |
Oesophageal cancer metastatic | 22.72 | 14.62 | 11 | 50803 | 325 | 31646205 |
Ileus paralytic | 22.52 | 14.62 | 35 | 50779 | 5373 | 31641157 |
Nasal congestion | 22.52 | 14.62 | 3 | 50811 | 20378 | 31626152 |
Mucosal toxicity | 22.38 | 14.62 | 10 | 50804 | 245 | 31646285 |
Urticaria | 22.38 | 14.62 | 36 | 50778 | 57481 | 31589049 |
Gastrointestinal mucosal necrosis | 22.30 | 14.62 | 9 | 50805 | 170 | 31646360 |
Chronic kidney disease | 22.21 | 14.62 | 17 | 50797 | 37958 | 31608572 |
Cholangitis | 21.91 | 14.62 | 43 | 50771 | 7943 | 31638587 |
Rash maculo-papular | 21.83 | 14.62 | 7 | 50807 | 25712 | 31620818 |
Lactic acidosis | 21.80 | 14.62 | 12 | 50802 | 31925 | 31614605 |
Treatment noncompliance | 21.78 | 14.62 | 7 | 50807 | 25677 | 31620853 |
Irritability | 21.74 | 14.62 | 5 | 50809 | 22884 | 31623646 |
Arthropathy | 21.40 | 14.62 | 6 | 50808 | 24045 | 31622485 |
Palmar erythema | 21.35 | 14.62 | 10 | 50804 | 274 | 31646256 |
Alanine aminotransferase increased | 21.19 | 14.62 | 56 | 50758 | 74600 | 31571930 |
Neutrophil count decreased | 21.10 | 14.62 | 137 | 50677 | 46257 | 31600273 |
Erectile dysfunction | 20.85 | 14.62 | 3 | 50811 | 19232 | 31627298 |
Cognitive disorder | 20.77 | 14.62 | 7 | 50807 | 24916 | 31621614 |
Failure to anastomose | 20.71 | 14.62 | 9 | 50805 | 206 | 31646324 |
Hepatic infarction | 20.67 | 14.62 | 9 | 50805 | 207 | 31646323 |
Somnolence | 20.40 | 14.62 | 86 | 50728 | 99359 | 31547171 |
Eosinophilia | 20.33 | 14.62 | 6 | 50808 | 23247 | 31623283 |
Heart rate decreased | 20.22 | 14.62 | 10 | 50804 | 28256 | 31618274 |
Hypertriglyceridaemia | 20.21 | 14.62 | 41 | 50773 | 7757 | 31638773 |
Change of bowel habit | 20 | 14.62 | 15 | 50799 | 996 | 31645534 |
Scleroderma-like reaction | 19.97 | 14.62 | 6 | 50808 | 44 | 31646486 |
Feeling cold | 19.91 | 14.62 | 46 | 50768 | 9508 | 31637022 |
Incisional hernia | 19.85 | 14.62 | 16 | 50798 | 1181 | 31645349 |
Oxygen saturation decreased | 19.81 | 14.62 | 30 | 50784 | 49085 | 31597445 |
Pulmonary hypertension | 19.80 | 14.62 | 4 | 50810 | 20037 | 31626493 |
Coronary artery disease | 19.73 | 14.62 | 27 | 50787 | 46060 | 31600470 |
Tremor | 19.72 | 14.62 | 60 | 50754 | 76360 | 31570170 |
Nephrotic syndrome | 19.57 | 14.62 | 38 | 50776 | 6965 | 31639565 |
Metastases to the mediastinum | 19.54 | 14.62 | 9 | 50805 | 237 | 31646293 |
Pharyngeal ulceration | 19.48 | 14.62 | 10 | 50804 | 336 | 31646194 |
Wrong technique in product usage process | 19.41 | 14.62 | 15 | 50799 | 33328 | 31613202 |
Therapeutic product effect prolonged | 19.34 | 14.62 | 9 | 50805 | 243 | 31646287 |
Haematemesis | 19.34 | 14.62 | 87 | 50727 | 25566 | 31620964 |
Basal cell carcinoma | 19.33 | 14.62 | 3 | 50811 | 18176 | 31628354 |
Cataract | 19.30 | 14.62 | 7 | 50807 | 23800 | 31622730 |
Nail bed inflammation | 19.09 | 14.62 | 8 | 50806 | 167 | 31646363 |
Hepatic atrophy | 18.91 | 14.62 | 8 | 50806 | 171 | 31646359 |
Gastrointestinal mucosal disorder | 18.89 | 14.62 | 10 | 50804 | 358 | 31646172 |
Scrotal ulcer | 18.82 | 14.62 | 10 | 50804 | 361 | 31646169 |
Upper respiratory tract infection | 18.75 | 14.62 | 12 | 50802 | 29410 | 31617120 |
Drug hypersensitivity | 18.73 | 14.62 | 57 | 50757 | 72542 | 31573988 |
Eosinophilic pneumonia chronic | 18.65 | 14.62 | 9 | 50805 | 264 | 31646266 |
Gastrointestinal injury | 18.64 | 14.62 | 10 | 50804 | 368 | 31646162 |
Ectropion | 18.58 | 14.62 | 7 | 50807 | 109 | 31646421 |
Eczema impetiginous | 18.27 | 14.62 | 5 | 50809 | 25 | 31646505 |
Metastases to pelvis | 18.13 | 14.62 | 9 | 50805 | 281 | 31646249 |
Anterior spinal artery syndrome | 18.09 | 14.62 | 4 | 50810 | 6 | 31646524 |
Venoocclusive liver disease | 18.07 | 14.62 | 38 | 50776 | 7374 | 31639156 |
Laryngeal discomfort | 18.02 | 14.62 | 8 | 50806 | 193 | 31646337 |
Gastrointestinal inflammation | 18.02 | 14.62 | 24 | 50790 | 3201 | 31643329 |
Leukopenia | 17.93 | 14.62 | 156 | 50658 | 57672 | 31588858 |
Cardiac failure | 17.83 | 14.62 | 74 | 50740 | 85879 | 31560651 |
Peripheral embolism | 17.71 | 14.62 | 14 | 50800 | 1005 | 31645525 |
Periportal sinus dilatation | 17.65 | 14.62 | 5 | 50809 | 29 | 31646501 |
Therapy partial responder | 17.60 | 14.62 | 35 | 50779 | 6527 | 31640003 |
Idiosyncratic drug reaction | 17.44 | 14.62 | 10 | 50804 | 420 | 31646110 |
Aortic thrombosis | 17.41 | 14.62 | 12 | 50802 | 698 | 31645832 |
Psychotic disorder | 17.33 | 14.62 | 7 | 50807 | 22286 | 31624244 |
Peripheral sensory neuropathy | 17.32 | 14.62 | 34 | 50780 | 6281 | 31640249 |
Varices oesophageal | 17.22 | 14.62 | 24 | 50790 | 3342 | 31643188 |
Blood glucose increased | 17.19 | 14.62 | 46 | 50768 | 61037 | 31585493 |
Dysaesthesia | 17.11 | 14.62 | 19 | 50795 | 2100 | 31644430 |
Swelling of eyelid | 17.09 | 14.62 | 13 | 50801 | 882 | 31645648 |
Metastases to eye | 17.06 | 14.62 | 6 | 50808 | 76 | 31646454 |
Intestinal ischaemia | 17.03 | 14.62 | 36 | 50778 | 7009 | 31639521 |
Delirium | 17.00 | 14.62 | 25 | 50789 | 41396 | 31605134 |
Balance disorder | 16.96 | 14.62 | 21 | 50793 | 37401 | 31609129 |
Vasospasm | 16.86 | 14.62 | 9 | 50805 | 328 | 31646202 |
Pneumatosis intestinalis | 16.84 | 14.62 | 25 | 50789 | 3686 | 31642844 |
Faeces pale | 16.82 | 14.62 | 15 | 50799 | 1272 | 31645258 |
Dry skin | 16.71 | 14.62 | 83 | 50731 | 25398 | 31621132 |
Metastases to meninges | 16.70 | 14.62 | 15 | 50799 | 1284 | 31645246 |
Pancreatic neuroendocrine tumour | 16.66 | 14.62 | 9 | 50805 | 336 | 31646194 |
Back pain | 16.57 | 14.62 | 105 | 50709 | 109308 | 31537222 |
Hot flush | 16.50 | 14.62 | 3 | 50811 | 16193 | 31630337 |
Hand-foot-genital syndrome | 16.48 | 14.62 | 4 | 50810 | 11 | 31646519 |
Depressed mood | 16.37 | 14.62 | 4 | 50810 | 17571 | 31628959 |
Urethral ulcer | 16.31 | 14.62 | 3 | 50811 | 0 | 31646530 |
Alopecia | 16.21 | 14.62 | 71 | 50743 | 20624 | 31625906 |
Interstitial lung disease | 16.20 | 14.62 | 160 | 50654 | 61243 | 31585287 |
Neutrophilia | 16.18 | 14.62 | 25 | 50789 | 3818 | 31642712 |
Liver injury | 16.14 | 14.62 | 53 | 50761 | 13439 | 31633091 |
Biliary fistula | 16.05 | 14.62 | 5 | 50809 | 42 | 31646488 |
Acute coronary syndrome | 15.99 | 14.62 | 51 | 50763 | 12738 | 31633792 |
Metastatic neoplasm | 15.95 | 14.62 | 21 | 50793 | 2770 | 31643760 |
Memory impairment | 15.66 | 14.62 | 23 | 50791 | 38107 | 31608423 |
Breast cancer metastatic | 15.65 | 14.62 | 5 | 50809 | 46 | 31646484 |
Neoplasm malignant | 15.64 | 14.62 | 66 | 50748 | 18865 | 31627665 |
Contusion | 15.54 | 14.62 | 18 | 50796 | 33010 | 31613520 |
Hyperammonaemia | 15.51 | 14.62 | 31 | 50783 | 5802 | 31640728 |
Peritoneal disorder | 15.49 | 14.62 | 8 | 50806 | 272 | 31646258 |
Prostatic calcification | 15.45 | 14.62 | 6 | 50808 | 102 | 31646428 |
Weight decreased | 15.40 | 14.62 | 350 | 50464 | 159602 | 31486928 |
Influenza like illness | 15.37 | 14.62 | 11 | 50803 | 25426 | 31621104 |
Ileal ulcer | 15.35 | 14.62 | 10 | 50804 | 529 | 31646001 |
Pancreatic carcinoma | 15.35 | 14.62 | 39 | 50775 | 8561 | 31637969 |
Carcinoid tumour pulmonary | 15.34 | 14.62 | 4 | 50810 | 16 | 31646514 |
Genital erythema | 15.28 | 14.62 | 7 | 50807 | 182 | 31646348 |
Malignant ascites | 15.27 | 14.62 | 9 | 50805 | 398 | 31646132 |
Acral peeling skin syndrome | 15.19 | 14.62 | 5 | 50809 | 51 | 31646479 |
Cryptitis | 15.19 | 14.62 | 5 | 50809 | 51 | 31646479 |
Phrenic nerve paralysis | 15.18 | 14.62 | 6 | 50808 | 107 | 31646423 |
Haemoglobin decreased | 15.15 | 14.62 | 112 | 50702 | 112563 | 31533967 |
Rosacea | 15.08 | 14.62 | 13 | 50801 | 1054 | 31645476 |
Neck pain | 15.08 | 14.62 | 9 | 50805 | 22901 | 31623629 |
Perineal ulceration | 14.96 | 14.62 | 4 | 50810 | 18 | 31646512 |
Electromyogram abnormal | 14.77 | 14.62 | 5 | 50809 | 56 | 31646474 |
Adenocarcinoma of colon | 14.75 | 14.62 | 22 | 50792 | 3258 | 31643272 |
Hypotension | 14.74 | 14.62 | 235 | 50579 | 204383 | 31442147 |
Hypoglycaemia | 14.62 | 14.62 | 38 | 50776 | 50908 | 31595622 |
MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
---|---|---|---|---|---|---|
Palmar-plantar erythrodysaesthesia syndrome | 7261.29 | 12.49 | 2487 | 116849 | 27760 | 70781348 |
Disease progression | 2917.71 | 12.49 | 2279 | 117057 | 154393 | 70654715 |
Diarrhoea | 2723.89 | 12.49 | 4762 | 114574 | 778579 | 70030529 |
Malignant neoplasm progression | 1134.06 | 12.49 | 1202 | 118134 | 120537 | 70688571 |
Mucosal inflammation | 1116.75 | 12.49 | 920 | 118416 | 66930 | 70742178 |
Metastases to liver | 1034.60 | 12.49 | 606 | 118730 | 25272 | 70783836 |
Neuropathy peripheral | 847.01 | 12.49 | 1055 | 118281 | 125841 | 70683267 |
Breast cancer metastatic | 770.41 | 12.49 | 365 | 118971 | 9781 | 70799327 |
Metastases to bone | 747.36 | 12.49 | 467 | 118869 | 21909 | 70787199 |
Death | 643.07 | 12.49 | 2099 | 117237 | 507962 | 70301146 |
Arteriospasm coronary | 629.95 | 12.49 | 271 | 119065 | 5753 | 70803355 |
Metastases to lung | 606.48 | 12.49 | 366 | 118970 | 16118 | 70792990 |
Vomiting | 525.75 | 12.49 | 2178 | 117158 | 590933 | 70218175 |
Rheumatoid arthritis | 473.66 | 12.49 | 3 | 119333 | 291802 | 70517306 |
Metastases to central nervous system | 430.82 | 12.49 | 285 | 119051 | 14749 | 70794359 |
Stomatitis | 428.04 | 12.49 | 772 | 118564 | 127739 | 70681369 |
Myelosuppression | 426.40 | 12.49 | 375 | 118961 | 29770 | 70779338 |
Nausea | 419.83 | 12.49 | 2653 | 116683 | 849435 | 69959673 |
Dehydration | 417.80 | 12.49 | 1069 | 118267 | 225073 | 70584035 |
Neurotoxicity | 409.85 | 12.49 | 365 | 118971 | 29461 | 70779647 |
Bone marrow failure | 396.65 | 12.49 | 450 | 118886 | 48560 | 70760548 |
Gastrointestinal toxicity | 389.29 | 12.49 | 198 | 119138 | 6207 | 70802901 |
Neutropenia | 371.34 | 12.49 | 1111 | 118225 | 256045 | 70553063 |
Completed suicide | 365.21 | 12.49 | 3 | 119333 | 227132 | 70581976 |
Drug ineffective | 351.64 | 12.49 | 656 | 118680 | 939096 | 69870012 |
Metastases to lymph nodes | 336.89 | 12.49 | 204 | 119132 | 9034 | 70800074 |
Enteritis | 331.21 | 12.49 | 228 | 119108 | 12603 | 70796505 |
Skin toxicity | 323.44 | 12.49 | 182 | 119154 | 7016 | 70802092 |
Breast cancer | 279.87 | 12.49 | 313 | 119023 | 33236 | 70775872 |
Arthralgia | 270.83 | 12.49 | 269 | 119067 | 503121 | 70305987 |
Neoplasm progression | 265.09 | 12.49 | 353 | 118983 | 44875 | 70764233 |
Decreased appetite | 260.72 | 12.49 | 1109 | 118227 | 303671 | 70505437 |
Condition aggravated | 259.48 | 12.49 | 204 | 119132 | 427431 | 70381677 |
Dihydropyrimidine dehydrogenase deficiency | 258.60 | 12.49 | 57 | 119279 | 77 | 70809031 |
Thrombocytopenia | 246.10 | 12.49 | 922 | 118414 | 238188 | 70570920 |
Skin exfoliation | 242.30 | 12.49 | 351 | 118985 | 48275 | 70760833 |
Cardiotoxicity | 235.78 | 12.49 | 175 | 119161 | 10895 | 70798213 |
Joint swelling | 233.78 | 12.49 | 68 | 119268 | 253143 | 70555965 |
Skin fissures | 228.54 | 12.49 | 173 | 119163 | 11097 | 70798011 |
Anastomotic leak | 216.97 | 12.49 | 77 | 119259 | 952 | 70808156 |
Gastrointestinal perforation | 203.41 | 12.49 | 124 | 119212 | 5557 | 70803551 |
Metastases to skin | 185.30 | 12.49 | 77 | 119259 | 1494 | 70807614 |
Haematotoxicity | 183.17 | 12.49 | 165 | 119171 | 13509 | 70795599 |
Enterocolitis | 177.66 | 12.49 | 159 | 119177 | 12907 | 70796201 |
Fall | 176.11 | 12.49 | 298 | 119038 | 443798 | 70365310 |
Laryngospasm | 166.08 | 12.49 | 93 | 119243 | 3550 | 70805558 |
Therapy cessation | 163.26 | 12.49 | 240 | 119096 | 33436 | 70775672 |
Skin discolouration | 161.10 | 12.49 | 252 | 119084 | 37073 | 70772035 |
Dry skin | 161.10 | 12.49 | 316 | 119020 | 55615 | 70753493 |
Contraindicated product administered | 160.58 | 12.49 | 19 | 119317 | 134593 | 70674515 |
Tumour marker increased | 159.88 | 12.49 | 92 | 119244 | 3702 | 70805406 |
Asthenia | 158.42 | 12.49 | 1312 | 118024 | 456354 | 70352754 |
Paronychia | 157.79 | 12.49 | 115 | 119221 | 6959 | 70802149 |
Drug interaction | 154.84 | 12.49 | 252 | 119084 | 381189 | 70427919 |
Arthropathy | 154.58 | 12.49 | 32 | 119304 | 150025 | 70659083 |
Therapeutic product effect decreased | 148.35 | 12.49 | 30 | 119306 | 142988 | 70666120 |
Intestinal obstruction | 145.65 | 12.49 | 246 | 119090 | 38579 | 70770529 |
Osteonecrosis of jaw | 144.90 | 12.49 | 253 | 119083 | 40749 | 70768359 |
Metastases to peritoneum | 143.54 | 12.49 | 86 | 119250 | 3733 | 70805375 |
Systemic lupus erythematosus | 142.17 | 12.49 | 7 | 119329 | 101895 | 70707213 |
Overdose | 141.88 | 12.49 | 54 | 119282 | 169691 | 70639417 |
Pseudocirrhosis | 138.34 | 12.49 | 49 | 119287 | 602 | 70808506 |
Hospice care | 136.32 | 12.49 | 112 | 119224 | 8093 | 70801015 |
Paraesthesia | 136.29 | 12.49 | 545 | 118791 | 144992 | 70664116 |
Sinusitis | 134.61 | 12.49 | 58 | 119278 | 169137 | 70639971 |
Musculoskeletal stiffness | 133.89 | 12.49 | 41 | 119295 | 147719 | 70661389 |
Maternal exposure during pregnancy | 133.40 | 12.49 | 18 | 119318 | 115327 | 70693781 |
Psoriasis | 127.64 | 12.49 | 10 | 119326 | 98423 | 70710685 |
Drug hypersensitivity | 126.76 | 12.49 | 153 | 119183 | 262306 | 70546802 |
Pneumonia | 126.52 | 12.49 | 545 | 118791 | 595687 | 70213421 |
Treatment failure | 125.30 | 12.49 | 43 | 119293 | 144099 | 70665009 |
Weight increased | 124.93 | 12.49 | 134 | 119202 | 242197 | 70566911 |
Non-cirrhotic portal hypertension | 122.82 | 12.49 | 40 | 119296 | 373 | 70808735 |
Intentional overdose | 122.22 | 12.49 | 12 | 119324 | 98423 | 70710685 |
Product use issue | 121.91 | 12.49 | 76 | 119260 | 179861 | 70629247 |
Headache | 118.61 | 12.49 | 538 | 118798 | 579867 | 70229241 |
Metastasis | 117.70 | 12.49 | 91 | 119245 | 6023 | 70803085 |
Carcinoembryonic antigen increased | 115.39 | 12.49 | 60 | 119276 | 1970 | 70807138 |
Breast cancer recurrent | 113.11 | 12.49 | 66 | 119270 | 2727 | 70806381 |
Depression | 112.97 | 12.49 | 101 | 119235 | 198873 | 70610235 |
Portal hypertension | 112.87 | 12.49 | 91 | 119245 | 6401 | 70802707 |
Plasma cell myeloma | 109.08 | 12.49 | 3 | 119333 | 73198 | 70735910 |
Anastomotic complication | 107.58 | 12.49 | 37 | 119299 | 414 | 70808694 |
Exposure during pregnancy | 105.55 | 12.49 | 12 | 119324 | 87705 | 70721403 |
Hepatic lesion | 104.78 | 12.49 | 85 | 119251 | 6032 | 70803076 |
Nail disorder | 104.08 | 12.49 | 107 | 119229 | 10317 | 70798791 |
PIK3CA-activated mutation | 102.52 | 12.49 | 38 | 119298 | 536 | 70808572 |
Cardiac failure congestive | 102.19 | 12.49 | 50 | 119286 | 135407 | 70673701 |
Lymphangiosis carcinomatosa | 99.01 | 12.49 | 53 | 119283 | 1848 | 70807260 |
Suicide attempt | 97.90 | 12.49 | 10 | 119326 | 79500 | 70729608 |
Influenza | 96.95 | 12.49 | 35 | 119301 | 113665 | 70695443 |
Abdominal pain | 96.20 | 12.49 | 938 | 118398 | 341189 | 70467919 |
Onycholysis | 95.97 | 12.49 | 51 | 119285 | 1752 | 70807356 |
Fingerprint loss | 94.14 | 12.49 | 22 | 119314 | 45 | 70809063 |
Colitis | 93.02 | 12.49 | 277 | 119059 | 63537 | 70745571 |
Colon cancer metastatic | 92.96 | 12.49 | 53 | 119283 | 2095 | 70807013 |
Polyneuropathy | 91.58 | 12.49 | 144 | 119192 | 21271 | 70787837 |
Ileus | 91.47 | 12.49 | 154 | 119182 | 24083 | 70785025 |
Dysaesthesia pharynx | 90.82 | 12.49 | 27 | 119309 | 180 | 70808928 |
Arthritis | 89.08 | 12.49 | 27 | 119309 | 97953 | 70711155 |
Ascites | 88.96 | 12.49 | 283 | 119053 | 67264 | 70741844 |
Bradycardia | 88.10 | 12.49 | 50 | 119286 | 124565 | 70684543 |
Hypokalaemia | 87.95 | 12.49 | 445 | 118891 | 130743 | 70678365 |
Glossodynia | 87.90 | 12.49 | 19 | 119317 | 86468 | 70722640 |
Metastases to pleura | 83.76 | 12.49 | 42 | 119294 | 1276 | 70807832 |
Carbohydrate antigen 15-3 increased | 83.18 | 12.49 | 39 | 119297 | 1019 | 70808089 |
Pruritus | 82.57 | 12.49 | 301 | 119035 | 345259 | 70463849 |
Asthma | 81.82 | 12.49 | 51 | 119285 | 120742 | 70688366 |
Hyperbilirubinaemia | 80.69 | 12.49 | 140 | 119196 | 22428 | 70786680 |
Metastatic neoplasm | 78.37 | 12.49 | 64 | 119272 | 4584 | 70804524 |
Intentional product misuse | 77.87 | 12.49 | 19 | 119317 | 79576 | 70729532 |
Tumour perforation | 75.70 | 12.49 | 27 | 119309 | 339 | 70808769 |
Recall phenomenon | 74 | 12.49 | 36 | 119300 | 1023 | 70808085 |
Colorectal cancer metastatic | 73.92 | 12.49 | 43 | 119293 | 1766 | 70807342 |
Metastases to spine | 73.72 | 12.49 | 57 | 119279 | 3772 | 70805336 |
Wound | 73.62 | 12.49 | 37 | 119299 | 98695 | 70710413 |
Hypovolaemic shock | 73.55 | 12.49 | 91 | 119245 | 10746 | 70798362 |
Urticaria | 73.54 | 12.49 | 100 | 119236 | 162949 | 70646159 |
Bronchitis | 72.10 | 12.49 | 55 | 119281 | 117188 | 70691920 |
Infusion site coldness | 71.64 | 12.49 | 23 | 119313 | 204 | 70808904 |
Suicidal ideation | 71.31 | 12.49 | 15 | 119321 | 69581 | 70739527 |
Injection site pain | 70.03 | 12.49 | 57 | 119279 | 117562 | 70691546 |
Anxiety | 69.91 | 12.49 | 168 | 119168 | 220162 | 70588946 |
Pulmonary embolism | 69.60 | 12.49 | 475 | 118861 | 155392 | 70653716 |
Chronic obstructive pulmonary disease | 69.49 | 12.49 | 22 | 119314 | 77619 | 70731489 |
Pain | 68.56 | 12.49 | 702 | 118634 | 628114 | 70180994 |
Leukopenia | 68.30 | 12.49 | 357 | 118979 | 106203 | 70702905 |
Rhabdomyolysis | 68.29 | 12.49 | 38 | 119298 | 95722 | 70713386 |
Osteoarthritis | 68.19 | 12.49 | 20 | 119316 | 74127 | 70734981 |
Product dose omission issue | 68.07 | 12.49 | 167 | 119169 | 217301 | 70591807 |
Bone lesion | 67.80 | 12.49 | 63 | 119273 | 5367 | 70803741 |
Gastric perforation | 65.32 | 12.49 | 53 | 119283 | 3762 | 70805346 |
Proteinuria | 64.89 | 12.49 | 149 | 119187 | 29225 | 70779883 |
Intestinal perforation | 64.65 | 12.49 | 105 | 119231 | 15939 | 70793169 |
Hypotension | 64.56 | 12.49 | 407 | 118929 | 403974 | 70405134 |
Pericarditis | 64.28 | 12.49 | 31 | 119305 | 84674 | 70724434 |
Blood pressure fluctuation | 64.12 | 12.49 | 11 | 119325 | 59001 | 70750107 |
Irritable bowel syndrome | 63.64 | 12.49 | 6 | 119330 | 50844 | 70758264 |
Swelling | 62.84 | 12.49 | 140 | 119196 | 188399 | 70620709 |
Mobility decreased | 62.46 | 12.49 | 49 | 119287 | 102950 | 70706158 |
Insomnia | 62.27 | 12.49 | 175 | 119161 | 217631 | 70591477 |
Confusional state | 61.96 | 12.49 | 257 | 119079 | 284141 | 70524967 |
Hypoaesthesia | 61.93 | 12.49 | 457 | 118879 | 153282 | 70655826 |
Ejection fraction decreased | 61.41 | 12.49 | 150 | 119186 | 30612 | 70778496 |
Wound dehiscence | 60.67 | 12.49 | 63 | 119273 | 6145 | 70802963 |
Gamma-glutamyltransferase decreased | 60.58 | 12.49 | 23 | 119313 | 348 | 70808760 |
Osteonecrosis | 60.15 | 12.49 | 144 | 119192 | 29016 | 70780092 |
Stomal varices | 59.87 | 12.49 | 15 | 119321 | 46 | 70809062 |
Electrocardiogram QT prolonged | 59.75 | 12.49 | 33 | 119303 | 83484 | 70725624 |
Mucosal toxicity | 59.64 | 12.49 | 26 | 119310 | 570 | 70808538 |
Feeling abnormal | 59.54 | 12.49 | 92 | 119244 | 142227 | 70666881 |
Therapy partial responder | 59.15 | 12.49 | 88 | 119248 | 12386 | 70796722 |
Fibromyalgia | 58.99 | 12.49 | 6 | 119330 | 47868 | 70761240 |
Dysaesthesia | 58.91 | 12.49 | 58 | 119278 | 5310 | 70803798 |
Fatigue | 58.78 | 12.49 | 1807 | 117529 | 822512 | 69986596 |
Drug reaction with eosinophilia and systemic symptoms | 58.43 | 12.49 | 13 | 119323 | 58000 | 70751108 |
Nail discolouration | 58.11 | 12.49 | 43 | 119293 | 2663 | 70806445 |
Nasal congestion | 58.08 | 12.49 | 19 | 119317 | 65653 | 70743455 |
Hepatic function abnormal | 57.58 | 12.49 | 247 | 119089 | 67749 | 70741359 |
Duodenal ulcer perforation | 56.71 | 12.49 | 9 | 119327 | 51103 | 70758005 |
Agitation | 55.89 | 12.49 | 45 | 119291 | 93330 | 70715778 |
Discomfort | 55.74 | 12.49 | 57 | 119279 | 105379 | 70703729 |
Metastases to meninges | 54.61 | 12.49 | 44 | 119292 | 3092 | 70806016 |
Device related thrombosis | 53.63 | 12.49 | 39 | 119297 | 2351 | 70806757 |
Hepatic enzyme increased | 53.60 | 12.49 | 115 | 119221 | 156875 | 70652233 |
Infusion related reaction | 53.34 | 12.49 | 163 | 119173 | 197371 | 70611737 |
Metastases to chest wall | 53.26 | 12.49 | 22 | 119314 | 420 | 70808688 |
Therapy change | 53.21 | 12.49 | 61 | 119275 | 6648 | 70802460 |
Wheezing | 53.17 | 12.49 | 48 | 119288 | 94122 | 70714986 |
Pancreatic neuroendocrine tumour metastatic | 53.13 | 12.49 | 17 | 119319 | 149 | 70808959 |
Subileus | 52.81 | 12.49 | 54 | 119282 | 5173 | 70803935 |
Dermatitis acneiform | 52.66 | 12.49 | 70 | 119266 | 8875 | 70800233 |
Gastrointestinal anastomotic leak | 51.96 | 12.49 | 22 | 119314 | 448 | 70808660 |
Platelet count decreased | 51.64 | 12.49 | 492 | 118844 | 177730 | 70631378 |
Acute kidney injury | 51.60 | 12.49 | 530 | 118806 | 474094 | 70335014 |
Performance status decreased | 51.46 | 12.49 | 55 | 119281 | 5546 | 70803562 |
Oesophagitis | 51.25 | 12.49 | 116 | 119220 | 22536 | 70786572 |
Peripheral sensory neuropathy | 51.18 | 12.49 | 81 | 119255 | 12029 | 70797079 |
Disseminated intravascular coagulation | 51.01 | 12.49 | 148 | 119188 | 33450 | 70775658 |
Acute coronary syndrome | 50.16 | 12.49 | 107 | 119229 | 19972 | 70789136 |
Nasopharyngitis | 50.14 | 12.49 | 198 | 119138 | 222008 | 70587100 |
Chronic kidney disease | 50.03 | 12.49 | 20 | 119316 | 61037 | 70748071 |
Skin hyperpigmentation | 49.83 | 12.49 | 59 | 119277 | 6656 | 70802452 |
Subacute cutaneous lupus erythematosus | 49.52 | 12.49 | 42 | 119294 | 3171 | 70805937 |
Cytomegalovirus infection | 48.94 | 12.49 | 5 | 119331 | 39753 | 70769355 |
Metastases to the mediastinum | 48.87 | 12.49 | 22 | 119314 | 522 | 70808586 |
Rectal cancer | 48.83 | 12.49 | 42 | 119294 | 3232 | 70805876 |
Blood bilirubin increased | 48.74 | 12.49 | 215 | 119121 | 59686 | 70749422 |
Neutrophil count decreased | 48.18 | 12.49 | 272 | 119064 | 83284 | 70725824 |
Wrong technique in product usage process | 47.92 | 12.49 | 28 | 119308 | 68670 | 70740438 |
Erythema | 47.85 | 12.49 | 530 | 118806 | 199033 | 70610075 |
Varices oesophageal | 47.68 | 12.49 | 52 | 119284 | 5365 | 70803743 |
Vascular pain | 47.63 | 12.49 | 25 | 119311 | 837 | 70808271 |
Oxygen saturation decreased | 47.05 | 12.49 | 77 | 119259 | 116352 | 70692756 |
Somnolence | 46.83 | 12.49 | 195 | 119141 | 215411 | 70593697 |
Abdominal lymphadenopathy | 46.51 | 12.49 | 28 | 119308 | 1226 | 70807882 |
Hyperkalaemia | 46.42 | 12.49 | 67 | 119269 | 106524 | 70702584 |
Lacrimation increased | 46.25 | 12.49 | 103 | 119233 | 19796 | 70789312 |
Hiccups | 46.02 | 12.49 | 66 | 119270 | 8986 | 70800122 |
Sedation | 46.01 | 12.49 | 11 | 119325 | 46720 | 70762388 |
Leukoencephalopathy | 45.92 | 12.49 | 59 | 119277 | 7235 | 70801873 |
Neutropenic sepsis | 45.29 | 12.49 | 117 | 119219 | 24713 | 70784395 |
Splenorenal shunt | 45.16 | 12.49 | 10 | 119326 | 14 | 70809094 |
Coronary artery disease | 44.57 | 12.49 | 25 | 119311 | 62711 | 70746397 |
Obstruction gastric | 44.26 | 12.49 | 29 | 119307 | 1475 | 70807633 |
Toxic leukoencephalopathy | 44.15 | 12.49 | 25 | 119311 | 975 | 70808133 |
Recurrent cancer | 44.10 | 12.49 | 35 | 119301 | 2406 | 70806702 |
Dysphagia | 44.06 | 12.49 | 333 | 119003 | 112501 | 70696607 |
Electrocardiogram ST segment elevation | 43.99 | 12.49 | 59 | 119277 | 7545 | 70801563 |
Injection site erythema | 43.82 | 12.49 | 35 | 119301 | 72889 | 70736219 |
Loss of personal independence in daily activities | 43.65 | 12.49 | 47 | 119289 | 84863 | 70724245 |
Mucosal disorder | 43.64 | 12.49 | 39 | 119297 | 3159 | 70805949 |
Myalgia | 43.59 | 12.49 | 141 | 119195 | 167751 | 70641357 |
Peritonitis | 43.40 | 12.49 | 119 | 119217 | 26040 | 70783068 |
Biliary obstruction | 43.24 | 12.49 | 43 | 119293 | 3984 | 70805124 |
Jaw operation | 43.12 | 12.49 | 23 | 119313 | 796 | 70808312 |
Abdominal discomfort | 43.07 | 12.49 | 200 | 119136 | 214458 | 70594650 |
Aggression | 42.87 | 12.49 | 14 | 119322 | 48432 | 70760676 |
COVID-19 | 42.68 | 12.49 | 70 | 119266 | 105687 | 70703421 |
Lower respiratory tract infection | 42.49 | 12.49 | 77 | 119259 | 111836 | 70697272 |
Injury | 42.20 | 12.49 | 29 | 119307 | 65216 | 70743892 |
Pyogenic granuloma | 41.63 | 12.49 | 19 | 119317 | 466 | 70808642 |
Infusion site induration | 41.45 | 12.49 | 23 | 119313 | 862 | 70808246 |
Drug level increased | 41.42 | 12.49 | 6 | 119330 | 36463 | 70772645 |
Arterial thrombosis | 41.31 | 12.49 | 34 | 119302 | 2462 | 70806646 |
Proteus infection | 41.27 | 12.49 | 29 | 119307 | 1656 | 70807452 |
Abnormal behaviour | 41.12 | 12.49 | 5 | 119331 | 34704 | 70774404 |
Focal nodular hyperplasia | 40.99 | 12.49 | 21 | 119315 | 668 | 70808440 |
Delirium | 40.98 | 12.49 | 39 | 119297 | 74575 | 70734533 |
Device occlusion | 40.88 | 12.49 | 68 | 119268 | 10527 | 70798581 |
Product use in unapproved indication | 40.63 | 12.49 | 195 | 119141 | 207283 | 70601825 |
Lactic acidosis | 40.61 | 12.49 | 30 | 119306 | 64994 | 70744114 |
Sleep apnoea syndrome | 40.56 | 12.49 | 4 | 119332 | 32709 | 70776399 |
Pulmonary hypertension | 40.21 | 12.49 | 14 | 119322 | 46522 | 70762586 |
Mouth ulceration | 39.94 | 12.49 | 138 | 119198 | 34211 | 70774897 |
Hepatic failure | 39.66 | 12.49 | 197 | 119139 | 57428 | 70751680 |
Basal cell carcinoma | 39.57 | 12.49 | 5 | 119331 | 33693 | 70775415 |
Rectal tenesmus | 39.38 | 12.49 | 26 | 119310 | 1340 | 70807768 |
Metastatic gastric cancer | 38.94 | 12.49 | 17 | 119319 | 374 | 70808734 |
Prothrombin level decreased | 38.89 | 12.49 | 27 | 119309 | 1512 | 70807596 |
Necrotising fasciitis | 38.46 | 12.49 | 47 | 119289 | 5479 | 70803629 |
Pulmonary arterial hypertension | 38.27 | 12.49 | 5 | 119331 | 32850 | 70776258 |
Portal shunt | 38.27 | 12.49 | 11 | 119325 | 64 | 70809044 |
Granulocyte count decreased | 38.18 | 12.49 | 26 | 119310 | 1411 | 70807697 |
Myocardial infarction | 38.04 | 12.49 | 154 | 119182 | 171491 | 70637617 |
Unresponsive to stimuli | 37.90 | 12.49 | 20 | 119316 | 51911 | 70757197 |
Tooth extraction | 37.84 | 12.49 | 64 | 119272 | 10043 | 70799065 |
Cold dysaesthesia | 37.58 | 12.49 | 8 | 119328 | 8 | 70809100 |
Loss of consciousness | 37.55 | 12.49 | 135 | 119201 | 155581 | 70653527 |
Diaphragmatic spasm | 37.52 | 12.49 | 12 | 119324 | 105 | 70809003 |
Biliary sepsis | 37.20 | 12.49 | 26 | 119310 | 1472 | 70807636 |
Lymphoedema | 36.98 | 12.49 | 67 | 119269 | 11102 | 70798006 |
Eosinophilia | 36.84 | 12.49 | 11 | 119325 | 40308 | 70768800 |
Anastomotic fistula | 36.55 | 12.49 | 12 | 119324 | 115 | 70808993 |
Metastases to ovary | 36.53 | 12.49 | 15 | 119321 | 282 | 70808826 |
Drug ineffective for unapproved indication | 36.16 | 12.49 | 10 | 119326 | 38528 | 70770580 |
Metastases to eye | 36.10 | 12.49 | 14 | 119322 | 225 | 70808883 |
Hypophagia | 35.96 | 12.49 | 152 | 119184 | 41418 | 70767690 |
Nervousness | 35.63 | 12.49 | 5 | 119331 | 31115 | 70777993 |
Ejection fraction | 35.61 | 12.49 | 27 | 119309 | 1735 | 70807373 |
Hypertriglyceridaemia | 35.54 | 12.49 | 68 | 119268 | 11743 | 70797365 |
Treatment noncompliance | 35.40 | 12.49 | 17 | 119319 | 46557 | 70762551 |
Cholangitis | 35.38 | 12.49 | 67 | 119269 | 11482 | 70797626 |
Adnexa uteri mass | 35.31 | 12.49 | 15 | 119321 | 308 | 70808800 |
Hallucination | 35.15 | 12.49 | 46 | 119290 | 76214 | 70732894 |
Large intestine perforation | 34.92 | 12.49 | 72 | 119264 | 13123 | 70795985 |
Prescribed overdose | 34.57 | 12.49 | 3 | 119333 | 27178 | 70781930 |
Therapy interrupted | 34.56 | 12.49 | 106 | 119230 | 24696 | 70784412 |
Cataract | 34.33 | 12.49 | 26 | 119310 | 55619 | 70753489 |
Jaundice | 34.27 | 12.49 | 171 | 119165 | 49937 | 70759171 |
Hepatic atrophy | 34.19 | 12.49 | 16 | 119320 | 416 | 70808692 |
Pigmentation disorder | 34.18 | 12.49 | 42 | 119294 | 4924 | 70804184 |
Small intestinal obstruction | 34.01 | 12.49 | 105 | 119231 | 24550 | 70784558 |
Thrombosis | 33.75 | 12.49 | 230 | 119106 | 75175 | 70733933 |
Bone disorder | 33.55 | 12.49 | 84 | 119252 | 17406 | 70791702 |
Depressed level of consciousness | 33.33 | 12.49 | 60 | 119276 | 87371 | 70721737 |
Prinzmetal angina | 33.24 | 12.49 | 25 | 119311 | 1587 | 70807521 |
Induration | 33.24 | 12.49 | 26 | 119310 | 1750 | 70807358 |
Colon cancer | 33.19 | 12.49 | 74 | 119262 | 14232 | 70794876 |
Pneumatosis intestinalis | 33.02 | 12.49 | 45 | 119291 | 5842 | 70803266 |
Hyperammonaemic encephalopathy | 32.91 | 12.49 | 39 | 119297 | 4404 | 70804704 |
General physical health deterioration | 32.88 | 12.49 | 569 | 118767 | 235462 | 70573646 |
Pleural effusion | 32.81 | 12.49 | 355 | 118981 | 132509 | 70676599 |
Faecal volume decreased | 32.59 | 12.49 | 12 | 119324 | 166 | 70808942 |
Blood uric acid decreased | 32.57 | 12.49 | 22 | 119314 | 1178 | 70807930 |
Blood pressure systolic increased | 32.54 | 12.49 | 29 | 119307 | 57230 | 70751878 |
Therapeutic product effect incomplete | 32.29 | 12.49 | 99 | 119237 | 119783 | 70689325 |
Adverse event | 31.96 | 12.49 | 22 | 119314 | 49439 | 70759669 |
Protein urine | 31.83 | 12.49 | 23 | 119313 | 1373 | 70807735 |
Pharyngeal inflammation | 31.71 | 12.49 | 20 | 119316 | 952 | 70808156 |
Dizziness | 31.33 | 12.49 | 571 | 118765 | 463570 | 70345538 |
Neoplasm malignant | 31.21 | 12.49 | 113 | 119223 | 28661 | 70780447 |
Stress cardiomyopathy | 31.19 | 12.49 | 58 | 119278 | 9804 | 70799304 |
Hypermutation | 31.08 | 12.49 | 9 | 119327 | 54 | 70809054 |
Cachexia | 31.03 | 12.49 | 58 | 119278 | 9842 | 70799266 |
Bone pain | 31.00 | 12.49 | 168 | 119168 | 50654 | 70758454 |
Medication error | 30.95 | 12.49 | 30 | 119306 | 56882 | 70752226 |
Abortion spontaneous | 30.92 | 12.49 | 4 | 119332 | 26475 | 70782633 |
Cytokine release syndrome | 30.90 | 12.49 | 4 | 119332 | 26463 | 70782645 |
Blood glucose increased | 30.71 | 12.49 | 81 | 119255 | 102901 | 70706207 |
Invasive ductal breast carcinoma | 30.48 | 12.49 | 43 | 119293 | 5766 | 70803342 |
Venoocclusive liver disease | 30.33 | 12.49 | 60 | 119276 | 10618 | 70798490 |
Contusion | 30.21 | 12.49 | 112 | 119224 | 127924 | 70681184 |
Debridement | 30.20 | 12.49 | 24 | 119312 | 1653 | 70807455 |
Folliculitis | 30.19 | 12.49 | 17 | 119319 | 42553 | 70766555 |
Respiratory arrest | 29.84 | 12.49 | 28 | 119308 | 53905 | 70755203 |
Hypoalbuminaemia | 29.77 | 12.49 | 85 | 119251 | 19037 | 70790071 |
Aortic thrombosis | 29.51 | 12.49 | 23 | 119313 | 1540 | 70807568 |
Malignant ascites | 29.44 | 12.49 | 20 | 119316 | 1081 | 70808027 |
Prostate cancer | 29.40 | 12.49 | 8 | 119328 | 31155 | 70777953 |
Necrotising oesophagitis | 29.27 | 12.49 | 17 | 119319 | 696 | 70808412 |
Plantar erythema | 29.21 | 12.49 | 13 | 119323 | 300 | 70808808 |
Emotional distress | 29.15 | 12.49 | 13 | 119323 | 37175 | 70771933 |
Urinary tract infection | 28.98 | 12.49 | 273 | 119063 | 248496 | 70560612 |
Triple negative breast cancer | 28.94 | 12.49 | 11 | 119325 | 167 | 70808941 |
Ectropion | 28.84 | 12.49 | 14 | 119322 | 396 | 70808712 |
Eosinophil percentage increased | 28.82 | 12.49 | 22 | 119314 | 1428 | 70807680 |
Nodular regenerative hyperplasia | 28.79 | 12.49 | 21 | 119315 | 1272 | 70807836 |
Clostridial infection | 28.79 | 12.49 | 40 | 119296 | 5289 | 70803819 |
Hand-foot-and-mouth disease | 28.77 | 12.49 | 12 | 119324 | 235 | 70808873 |
Pelvic fluid collection | 28.77 | 12.49 | 17 | 119319 | 719 | 70808389 |
Osteoporosis | 28.73 | 12.49 | 24 | 119312 | 48883 | 70760225 |
Withdrawal syndrome | 28.51 | 12.49 | 4 | 119332 | 24900 | 70784208 |
Nail infection | 28.48 | 12.49 | 26 | 119310 | 2165 | 70806943 |
Asthenopia | 28.43 | 12.49 | 26 | 119310 | 2170 | 70806938 |
Psychotic disorder | 28.29 | 12.49 | 14 | 119322 | 37687 | 70771421 |
Hyperammonaemia | 28.23 | 12.49 | 57 | 119279 | 10236 | 70798872 |
Haematoma | 28.15 | 12.49 | 24 | 119312 | 48394 | 70760714 |
Weight decreased | 27.98 | 12.49 | 702 | 118634 | 309786 | 70499322 |
Hypervolaemia | 27.95 | 12.49 | 16 | 119320 | 39690 | 70769418 |
Angioedema | 27.90 | 12.49 | 43 | 119293 | 66567 | 70742541 |
Anal erythema | 27.86 | 12.49 | 11 | 119325 | 186 | 70808922 |
Stoma site haemorrhage | 27.70 | 12.49 | 23 | 119313 | 1686 | 70807422 |
Irritability | 27.49 | 12.49 | 15 | 119321 | 38210 | 70770898 |
Tumour pain | 27.47 | 12.49 | 25 | 119311 | 2073 | 70807035 |
Constipation | 27.46 | 12.49 | 586 | 118750 | 251852 | 70557256 |
Fluid retention | 27.44 | 12.49 | 40 | 119296 | 63345 | 70745763 |
Acute respiratory failure | 27.25 | 12.49 | 30 | 119306 | 53635 | 70755473 |
Pulmonary mass | 27.20 | 12.49 | 101 | 119235 | 25932 | 70783176 |
Device issue | 27.18 | 12.49 | 4 | 119332 | 24021 | 70785087 |
Hyperfibrinolysis | 26.91 | 12.49 | 7 | 119329 | 26 | 70809082 |
Rectal perforation | 26.87 | 12.49 | 17 | 119319 | 814 | 70808294 |
Angina bullosa haemorrhagica | 26.78 | 12.49 | 11 | 119325 | 207 | 70808901 |
Skin reaction | 26.45 | 12.49 | 67 | 119269 | 13982 | 70795126 |
Tooth erosion | 26.29 | 12.49 | 13 | 119323 | 383 | 70808725 |
Upper respiratory tract infection | 26.28 | 12.49 | 59 | 119277 | 79215 | 70729893 |
Oesophageal haemorrhage | 26.26 | 12.49 | 22 | 119314 | 1633 | 70807475 |
Respiratory depression | 26.17 | 12.49 | 5 | 119331 | 24826 | 70784282 |
Cryptitis | 26.14 | 12.49 | 9 | 119327 | 101 | 70809007 |
Inappropriate schedule of product administration | 26.08 | 12.49 | 93 | 119243 | 107462 | 70701646 |
Joint range of motion decreased | 25.87 | 12.49 | 6 | 119330 | 26020 | 70783088 |
White blood cell count decreased | 25.83 | 12.49 | 416 | 118920 | 169725 | 70639383 |
Bone sequestrum | 25.82 | 12.49 | 19 | 119317 | 1167 | 70807941 |
Gastrointestinal inflammation | 25.74 | 12.49 | 43 | 119293 | 6680 | 70802428 |
Product prescribing error | 25.61 | 12.49 | 17 | 119319 | 38935 | 70770173 |
Hyperhidrosis | 25.56 | 12.49 | 124 | 119212 | 131462 | 70677646 |
Blood creatinine decreased | 25.50 | 12.49 | 45 | 119291 | 7304 | 70801804 |
Hypoglycaemia | 25.36 | 12.49 | 78 | 119258 | 94286 | 70714822 |
Disturbance in attention | 25.26 | 12.49 | 21 | 119315 | 42873 | 70766235 |
Dysgeusia | 25.21 | 12.49 | 156 | 119180 | 49346 | 70759762 |
C-reactive protein increased | 25.21 | 12.49 | 98 | 119238 | 110419 | 70698689 |
Neck pain | 25.17 | 12.49 | 46 | 119290 | 66611 | 70742497 |
Obesity | 25.02 | 12.49 | 7 | 119329 | 26764 | 70782344 |
Vein disorder | 25.01 | 12.49 | 34 | 119302 | 4404 | 70804704 |
Heart rate increased | 24.94 | 12.49 | 93 | 119243 | 106055 | 70703053 |
Accidental overdose | 24.94 | 12.49 | 14 | 119322 | 35107 | 70774001 |
Blood cholesterol increased | 24.92 | 12.49 | 44 | 119292 | 64560 | 70744548 |
Cognitive disorder | 24.91 | 12.49 | 40 | 119296 | 60916 | 70748192 |
Post-traumatic neck syndrome | 24.84 | 12.49 | 23 | 119313 | 1950 | 70807158 |
Early satiety | 24.83 | 12.49 | 19 | 119317 | 1238 | 70807870 |
Congestive cardiomyopathy | 24.77 | 12.49 | 56 | 119280 | 10870 | 70798238 |
Steatohepatitis | 24.61 | 12.49 | 16 | 119320 | 803 | 70808305 |
Migraine | 24.57 | 12.49 | 53 | 119283 | 72185 | 70736923 |
Extrapyramidal disorder | 24.55 | 12.49 | 3 | 119333 | 20747 | 70788361 |
Vasodilatation | 24.36 | 12.49 | 28 | 119308 | 3060 | 70806048 |
Metastases to pelvis | 24.36 | 12.49 | 14 | 119322 | 562 | 70808546 |
Tendonitis | 24.30 | 12.49 | 4 | 119332 | 22118 | 70786990 |
Hepatitis | 24.23 | 12.49 | 29 | 119307 | 49951 | 70759157 |
Abdominal distension | 24.16 | 12.49 | 276 | 119060 | 104393 | 70704715 |
Hospitalisation | 23.92 | 12.49 | 228 | 119108 | 82340 | 70726768 |
Vessel puncture site bruise | 23.75 | 12.49 | 13 | 119323 | 474 | 70808634 |
Peripheral sensorimotor neuropathy | 23.73 | 12.49 | 26 | 119310 | 2696 | 70806412 |
Ear infection | 23.68 | 12.49 | 9 | 119327 | 28327 | 70780781 |
Intestinal metastasis | 23.65 | 12.49 | 11 | 119325 | 282 | 70808826 |
Gastrointestinal mucosal necrosis | 23.65 | 12.49 | 10 | 119326 | 203 | 70808905 |
Temperature intolerance | 23.56 | 12.49 | 48 | 119288 | 8675 | 70800433 |
Ileal ulcer | 23.54 | 12.49 | 17 | 119319 | 1014 | 70808094 |
Human epidermal growth factor receptor negative | 23.49 | 12.49 | 5 | 119331 | 5 | 70809103 |
Brachiocephalic vein thrombosis | 23.42 | 12.49 | 10 | 119326 | 208 | 70808900 |
Oral pain | 23.39 | 12.49 | 104 | 119232 | 28962 | 70780146 |
Cardiac output decreased | 23.31 | 12.49 | 21 | 119315 | 1719 | 70807389 |
Accidental exposure to product | 23.29 | 12.49 | 9 | 119327 | 28042 | 70781066 |
Injection site haemorrhage | 23.26 | 12.49 | 7 | 119329 | 25520 | 70783588 |
Oral pigmentation | 23.13 | 12.49 | 6 | 119330 | 22 | 70809086 |
Atrial fibrillation | 22.90 | 12.49 | 199 | 119137 | 184149 | 70624959 |
Acute myeloid leukaemia | 22.89 | 12.49 | 108 | 119228 | 30832 | 70778276 |
Syncope | 22.82 | 12.49 | 174 | 119162 | 165535 | 70643573 |
Lymphadenopathy mediastinal | 22.81 | 12.49 | 31 | 119305 | 4014 | 70805094 |
Carbohydrate antigen 19-9 increased | 22.77 | 12.49 | 12 | 119324 | 405 | 70808703 |
Tenderness | 22.76 | 12.49 | 83 | 119253 | 21127 | 70787981 |
Disease recurrence | 22.73 | 12.49 | 124 | 119212 | 37479 | 70771629 |
Gastrointestinal stoma necrosis | 22.72 | 12.49 | 6 | 119330 | 24 | 70809084 |
Failure to anastomose | 22.66 | 12.49 | 10 | 119326 | 226 | 70808882 |
Coma | 22.55 | 12.49 | 79 | 119257 | 91765 | 70717343 |
Renal hydrocele | 22.52 | 12.49 | 6 | 119330 | 25 | 70809083 |
Drug eruption | 22.45 | 12.49 | 20 | 119316 | 39476 | 70769632 |
Dental care | 22.43 | 12.49 | 15 | 119321 | 790 | 70808318 |
Right ventricular failure | 22.41 | 12.49 | 5 | 119331 | 22269 | 70786839 |
Rhinorrhoea | 22.32 | 12.49 | 49 | 119287 | 66322 | 70742786 |
Hormone receptor positive breast cancer | 22.31 | 12.49 | 11 | 119325 | 322 | 70808786 |
Eye pain | 22.26 | 12.49 | 15 | 119321 | 34087 | 70775021 |
Peripheral ischaemia | 22.26 | 12.49 | 47 | 119289 | 8711 | 70800397 |
Haemorrhage intracranial | 22.20 | 12.49 | 7 | 119329 | 24770 | 70784338 |
Adenocarcinoma | 22.14 | 12.49 | 29 | 119307 | 3624 | 70805484 |
Pericardial effusion | 22.13 | 12.49 | 133 | 119203 | 41643 | 70767465 |
Foot deformity | 22.11 | 12.49 | 4 | 119332 | 20651 | 70788457 |
Large intestinal obstruction | 22.05 | 12.49 | 26 | 119310 | 2920 | 70806188 |
Restlessness | 22.00 | 12.49 | 23 | 119313 | 42105 | 70767003 |
Neoplasm recurrence | 21.92 | 12.49 | 30 | 119306 | 3911 | 70805197 |
Joint injury | 21.77 | 12.49 | 9 | 119327 | 26923 | 70782185 |
Carcinoid tumour pulmonary | 21.76 | 12.49 | 11 | 119325 | 340 | 70808768 |
Neuroendocrine breast tumour | 21.64 | 12.49 | 6 | 119330 | 30 | 70809078 |
Small intestinal perforation | 21.61 | 12.49 | 26 | 119310 | 2983 | 70806125 |
No adverse event | 21.47 | 12.49 | 109 | 119227 | 32044 | 70777064 |
Mucosal necrosis | 21.45 | 12.49 | 8 | 119328 | 115 | 70808993 |
ECG signs of myocardial ischaemia | 21.44 | 12.49 | 11 | 119325 | 351 | 70808757 |
Stress | 21.39 | 12.49 | 52 | 119284 | 67914 | 70741194 |
Exposed bone in jaw | 21.24 | 12.49 | 28 | 119308 | 3521 | 70805587 |
Incorrect route of product administration | 21.18 | 12.49 | 9 | 119327 | 26483 | 70782625 |
Multiple sclerosis | 21.18 | 12.49 | 8 | 119328 | 25277 | 70783831 |
Gingival bleeding | 21.13 | 12.49 | 65 | 119271 | 15167 | 70793941 |
Metastases to breast | 21.02 | 12.49 | 10 | 119326 | 270 | 70808838 |
Premature delivery | 21.00 | 12.49 | 5 | 119331 | 21299 | 70787809 |
Onychomadesis | 20.99 | 12.49 | 30 | 119306 | 4071 | 70805037 |
Poisoning | 20.98 | 12.49 | 6 | 119330 | 22616 | 70786492 |
Type 2 diabetes mellitus | 20.92 | 12.49 | 26 | 119310 | 44054 | 70765054 |
Colon cancer recurrent | 20.90 | 12.49 | 8 | 119328 | 124 | 70808984 |
Anal prolapse | 20.88 | 12.49 | 7 | 119329 | 72 | 70809036 |
Limbal stem cell deficiency | 20.86 | 12.49 | 6 | 119330 | 35 | 70809073 |
Hallucination, auditory | 20.85 | 12.49 | 3 | 119333 | 18325 | 70790783 |
Pregnancy | 20.81 | 12.49 | 7 | 119329 | 23774 | 70785334 |
Malignant pleural effusion | 20.73 | 12.49 | 26 | 119310 | 3113 | 70805995 |
Fistula | 20.60 | 12.49 | 52 | 119284 | 10829 | 70798279 |
Periportal sinus dilatation | 20.58 | 12.49 | 6 | 119330 | 37 | 70809071 |
Transaminases | 20.54 | 12.49 | 7 | 119329 | 76 | 70809032 |
Computerised tomogram abnormal | 20.35 | 12.49 | 26 | 119310 | 3170 | 70805938 |
Sciatica | 20.28 | 12.49 | 8 | 119328 | 24619 | 70784489 |
Incorrect dose administered | 20.25 | 12.49 | 52 | 119284 | 66667 | 70742441 |
Intestinal dilatation | 20.10 | 12.49 | 22 | 119314 | 2278 | 70806830 |
Rectal cancer metastatic | 20.07 | 12.49 | 12 | 119324 | 519 | 70808589 |
Pneumocystis jirovecii pneumonia | 19.95 | 12.49 | 13 | 119323 | 30069 | 70779039 |
Superior vena cava syndrome | 19.76 | 12.49 | 16 | 119320 | 1132 | 70807976 |
Febrile neutropenia | 19.60 | 12.49 | 466 | 118870 | 203852 | 70605256 |
Injection site bruising | 19.60 | 12.49 | 21 | 119315 | 38011 | 70771097 |
Pancreatitis viral | 19.57 | 12.49 | 5 | 119331 | 17 | 70809091 |
Terminal ileitis | 19.55 | 12.49 | 13 | 119323 | 678 | 70808430 |
Productive cough | 19.49 | 12.49 | 67 | 119269 | 78270 | 70730838 |
Toxicity to various agents | 19.40 | 12.49 | 492 | 118844 | 381680 | 70427428 |
Bone debridement | 19.22 | 12.49 | 11 | 119325 | 438 | 70808670 |
Obstructive airways disorder | 19.14 | 12.49 | 10 | 119326 | 26103 | 70783005 |
Infusion site hypoaesthesia | 19.14 | 12.49 | 5 | 119331 | 19 | 70809089 |
Hallucination, visual | 19.02 | 12.49 | 13 | 119323 | 29324 | 70779784 |
Sinus bradycardia | 18.93 | 12.49 | 8 | 119328 | 23615 | 70785493 |
Viral infection | 18.91 | 12.49 | 22 | 119314 | 38369 | 70770739 |
Ventricular fibrillation | 18.88 | 12.49 | 93 | 119243 | 27018 | 70782090 |
Hepatic infarction | 18.85 | 12.49 | 14 | 119322 | 872 | 70808236 |
Hypersplenism | 18.82 | 12.49 | 11 | 119325 | 456 | 70808652 |
Metastases to stomach | 18.72 | 12.49 | 9 | 119327 | 249 | 70808859 |
Metastases to adrenals | 18.66 | 12.49 | 16 | 119320 | 1226 | 70807882 |
Panic attack | 18.52 | 12.49 | 7 | 119329 | 22112 | 70786996 |
Lymphadenopathy | 18.48 | 12.49 | 143 | 119193 | 48648 | 70760460 |
Enterocolitis haemorrhagic | 18.46 | 12.49 | 20 | 119316 | 2048 | 70807060 |
Metastases to thorax | 18.45 | 12.49 | 8 | 119328 | 173 | 70808935 |
Aplastic anaemia | 18.41 | 12.49 | 3 | 119333 | 16713 | 70792395 |
Vertebral column mass | 18.41 | 12.49 | 8 | 119328 | 174 | 70808934 |
Eosinophilic pneumonia chronic | 18.41 | 12.49 | 11 | 119325 | 475 | 70808633 |
Gastrointestinal disorder | 18.39 | 12.49 | 264 | 119072 | 105163 | 70703945 |
Renal vein thrombosis | 18.37 | 12.49 | 11 | 119325 | 477 | 70808631 |
Generalised tonic-clonic seizure | 18.32 | 12.49 | 26 | 119310 | 41635 | 70767473 |
Blood pressure increased | 18.24 | 12.49 | 216 | 119120 | 188301 | 70620807 |
Gastric cancer | 18.23 | 12.49 | 44 | 119292 | 8911 | 70800197 |
Hyperglycaemic hyperosmolar nonketotic syndrome | 18.18 | 12.49 | 19 | 119317 | 1867 | 70807241 |
Toothache | 18.01 | 12.49 | 70 | 119266 | 18360 | 70790748 |
Acute promyelocytic leukaemia | 17.93 | 12.49 | 17 | 119319 | 1485 | 70807623 |
Hepatic cyst | 17.91 | 12.49 | 33 | 119303 | 5538 | 70803570 |
Brain neoplasm | 17.87 | 12.49 | 32 | 119304 | 5254 | 70803854 |
Back pain | 17.82 | 12.49 | 335 | 119001 | 270817 | 70538291 |
Cardio-respiratory arrest | 17.78 | 12.49 | 98 | 119238 | 100579 | 70708529 |
Retroperitoneal neoplasm metastatic | 17.71 | 12.49 | 5 | 119331 | 27 | 70809081 |
Prostatic calcification | 17.70 | 12.49 | 6 | 119330 | 64 | 70809044 |
Dyskinesia | 17.70 | 12.49 | 26 | 119310 | 41048 | 70768060 |
Respiratory tract congestion | 17.68 | 12.49 | 4 | 119332 | 17649 | 70791459 |
Peripheral motor neuropathy | 17.66 | 12.49 | 24 | 119312 | 3108 | 70806000 |
Haemoglobin decreased | 17.64 | 12.49 | 241 | 119095 | 204918 | 70604190 |
Diabetes mellitus inadequate control | 17.62 | 12.49 | 8 | 119328 | 22637 | 70786471 |
Motion sickness | 17.60 | 12.49 | 13 | 119323 | 803 | 70808305 |
Odynophagia | 17.59 | 12.49 | 47 | 119289 | 10128 | 70798980 |
Mydriasis | 17.57 | 12.49 | 3 | 119333 | 16150 | 70792958 |
Perineal ulceration | 17.54 | 12.49 | 6 | 119330 | 66 | 70809042 |
Sputum discoloured | 17.48 | 12.49 | 5 | 119331 | 18846 | 70790262 |
Hypercalcaemia of malignancy | 17.48 | 12.49 | 10 | 119326 | 398 | 70808710 |
Device dislocation | 17.43 | 12.49 | 8 | 119328 | 22499 | 70786609 |
Peritoneal disorder | 17.41 | 12.49 | 12 | 119324 | 664 | 70808444 |
Adenocarcinoma of colon | 17.41 | 12.49 | 32 | 119304 | 5360 | 70803748 |
Herpangina | 17.41 | 12.49 | 5 | 119331 | 29 | 70809079 |
Eczema impetiginous | 17.41 | 12.49 | 5 | 119331 | 29 | 70809079 |
Hyperaesthesia | 17.38 | 12.49 | 49 | 119287 | 10893 | 70798215 |
Gastroenteritis radiation | 17.24 | 12.49 | 12 | 119324 | 675 | 70808433 |
Memory impairment | 17.01 | 12.49 | 89 | 119247 | 92552 | 70716556 |
Osteolysis | 16.93 | 12.49 | 25 | 119311 | 3494 | 70805614 |
Breast necrosis | 16.92 | 12.49 | 6 | 119330 | 74 | 70809034 |
Blood creatine phosphokinase increased | 16.92 | 12.49 | 50 | 119286 | 61213 | 70747895 |
Restless legs syndrome | 16.88 | 12.49 | 5 | 119331 | 18423 | 70790685 |
Venous thrombosis limb | 16.87 | 12.49 | 27 | 119309 | 4048 | 70805060 |
Ileus paralytic | 16.72 | 12.49 | 42 | 119294 | 8719 | 70800389 |
Product administration error | 16.72 | 12.49 | 15 | 119321 | 29508 | 70779600 |
Myoclonus | 16.66 | 12.49 | 12 | 119324 | 26343 | 70782765 |
Hydronephrosis | 16.65 | 12.49 | 60 | 119276 | 15182 | 70793926 |
Infusion site haemorrhage | 16.53 | 12.49 | 22 | 119314 | 2793 | 70806315 |
Gastric dilatation | 16.49 | 12.49 | 15 | 119321 | 1243 | 70807865 |
Hypoacusis | 16.49 | 12.49 | 13 | 119323 | 27256 | 70781852 |
Dark circles under eyes | 16.46 | 12.49 | 10 | 119326 | 445 | 70808663 |
Biliary fistula | 16.43 | 12.49 | 6 | 119330 | 81 | 70809027 |
Perforation | 16.42 | 12.49 | 15 | 119321 | 1250 | 70807858 |
Tremor | 16.35 | 12.49 | 175 | 119161 | 155449 | 70653659 |
Head injury | 16.35 | 12.49 | 20 | 119316 | 34121 | 70774987 |
Parkinsonism | 16.33 | 12.49 | 3 | 119333 | 15322 | 70793786 |
Hand-foot-genital syndrome | 16.29 | 12.49 | 4 | 119332 | 11 | 70809097 |
Disorientation | 16.19 | 12.49 | 47 | 119289 | 57876 | 70751232 |
Urethral ulcer | 16.17 | 12.49 | 3 | 119333 | 0 | 70809108 |
Dermatoglyphic anomaly | 16.17 | 12.49 | 3 | 119333 | 0 | 70809108 |
Hyperchylomicronaemia | 16.17 | 12.49 | 3 | 119333 | 0 | 70809108 |
Delusion | 16.16 | 12.49 | 6 | 119330 | 19159 | 70789949 |
Toxic epidermal necrolysis | 16.12 | 12.49 | 26 | 119310 | 39531 | 70769577 |
Drug intolerance | 16.03 | 12.49 | 275 | 119061 | 225412 | 70583696 |
Brain operation | 15.99 | 12.49 | 11 | 119325 | 607 | 70808501 |
Pancreatic fistula | 15.91 | 12.49 | 6 | 119330 | 89 | 70809019 |
Gallbladder disorder | 15.88 | 12.49 | 5 | 119331 | 17707 | 70791401 |
Hypoxia | 15.87 | 12.49 | 92 | 119244 | 93252 | 70715856 |
Oropharyngeal pain | 15.80 | 12.49 | 96 | 119240 | 96214 | 70712894 |
Radiation myelopathy | 15.79 | 12.49 | 4 | 119332 | 13 | 70809095 |
Colitis ischaemic | 15.74 | 12.49 | 56 | 119280 | 14081 | 70795027 |
International normalised ratio increased | 15.71 | 12.49 | 76 | 119260 | 80650 | 70728458 |
Ataxia | 15.71 | 12.49 | 79 | 119257 | 23138 | 70785970 |
Tumour invasion | 15.69 | 12.49 | 9 | 119327 | 360 | 70808748 |
Seizure | 15.68 | 12.49 | 208 | 119128 | 177754 | 70631354 |
Periodontitis | 15.67 | 12.49 | 27 | 119309 | 4301 | 70804807 |
Lymphocyte count decreased | 15.60 | 12.49 | 31 | 119305 | 43508 | 70765600 |
Vulval disorder | 15.60 | 12.49 | 10 | 119326 | 490 | 70808618 |
Epistaxis | 15.59 | 12.49 | 251 | 119085 | 102376 | 70706732 |
Vasospasm | 15.46 | 12.49 | 13 | 119323 | 970 | 70808138 |
Bronchopulmonary aspergillosis | 15.46 | 12.49 | 8 | 119328 | 20994 | 70788114 |
Haemodialysis | 15.39 | 12.49 | 5 | 119331 | 17361 | 70791747 |
Liver abscess | 15.35 | 12.49 | 31 | 119305 | 5568 | 70803540 |
Subdural haematoma | 15.30 | 12.49 | 16 | 119320 | 29282 | 70779826 |
Calcium ionised increased | 15.29 | 12.49 | 7 | 119329 | 173 | 70808935 |
Paranoia | 15.29 | 12.49 | 5 | 119331 | 17283 | 70791825 |
Dystonia | 15.27 | 12.49 | 7 | 119329 | 19699 | 70789409 |
Injection site swelling | 15.23 | 12.49 | 31 | 119305 | 43126 | 70765982 |
Mental disorder | 15.22 | 12.49 | 15 | 119321 | 28225 | 70780883 |
Liver scan abnormal | 15.22 | 12.49 | 5 | 119331 | 48 | 70809060 |
Cough | 15.16 | 12.49 | 424 | 118912 | 324953 | 70484155 |
Joint dislocation | 15.16 | 12.49 | 3 | 119333 | 14528 | 70794580 |
Colitis ulcerative | 15.08 | 12.49 | 21 | 119315 | 33902 | 70775206 |
Mood swings | 14.96 | 12.49 | 6 | 119330 | 18280 | 70790828 |
Nail avulsion | 14.95 | 12.49 | 6 | 119330 | 106 | 70809002 |
Acral peeling skin syndrome | 14.95 | 12.49 | 5 | 119331 | 51 | 70809057 |
Fungal infection | 14.92 | 12.49 | 25 | 119311 | 37442 | 70771666 |
Radiation fibrosis - lung | 14.87 | 12.49 | 5 | 119331 | 52 | 70809056 |
Dysphonia | 14.83 | 12.49 | 139 | 119197 | 49961 | 70759147 |
Amnesia | 14.81 | 12.49 | 42 | 119294 | 52113 | 70756995 |
Nail bed inflammation | 14.79 | 12.49 | 10 | 119326 | 536 | 70808572 |
Proctalgia | 14.77 | 12.49 | 39 | 119297 | 8344 | 70800764 |
Appendicitis noninfective | 14.77 | 12.49 | 4 | 119332 | 18 | 70809090 |
Chemical peritonitis | 14.74 | 12.49 | 8 | 119328 | 287 | 70808821 |
Torsade de pointes | 14.73 | 12.49 | 6 | 119330 | 18110 | 70790998 |
Post procedural diarrhoea | 14.73 | 12.49 | 10 | 119326 | 540 | 70808568 |
Mechanical ileus | 14.71 | 12.49 | 11 | 119325 | 692 | 70808416 |
Diverticulitis | 14.71 | 12.49 | 30 | 119306 | 41704 | 70767404 |
Gastrointestinal injury | 14.70 | 12.49 | 12 | 119324 | 859 | 70808249 |
Femoral artery embolism | 14.70 | 12.49 | 5 | 119331 | 54 | 70809054 |
Anhedonia | 14.69 | 12.49 | 3 | 119333 | 14210 | 70794898 |
Pulpitis dental | 14.62 | 12.49 | 13 | 119323 | 1046 | 70808062 |
Hyperbaric oxygen therapy | 14.61 | 12.49 | 5 | 119331 | 55 | 70809053 |
Paraneoplastic dermatomyositis | 14.61 | 12.49 | 5 | 119331 | 55 | 70809053 |
Peritoneal fluid analysis abnormal | 14.61 | 12.49 | 5 | 119331 | 55 | 70809053 |
Malignant peritoneal neoplasm | 14.55 | 12.49 | 11 | 119325 | 704 | 70808404 |
Gastrointestinal oedema | 14.53 | 12.49 | 19 | 119317 | 2371 | 70806737 |
Dermatitis | 14.52 | 12.49 | 68 | 119268 | 19349 | 70789759 |
Orthostatic hypotension | 14.45 | 12.49 | 42 | 119294 | 51701 | 70757407 |
Laryngeal discomfort | 14.45 | 12.49 | 10 | 119326 | 557 | 70808551 |
Cardiac failure | 14.45 | 12.49 | 163 | 119173 | 143378 | 70665730 |
Acute generalised exanthematous pustulosis | 14.44 | 12.49 | 4 | 119332 | 15393 | 70793715 |
Skin disorder | 14.42 | 12.49 | 94 | 119242 | 30263 | 70778845 |
Chemotherapy cardiotoxicity attenuation | 14.42 | 12.49 | 4 | 119332 | 20 | 70809088 |
Neoplasm | 14.40 | 12.49 | 37 | 119299 | 7787 | 70801321 |
Peripheral swelling | 14.40 | 12.49 | 296 | 119040 | 236267 | 70572841 |
Metastases to spleen | 14.39 | 12.49 | 10 | 119326 | 561 | 70808547 |
Rectal neoplasm | 14.38 | 12.49 | 5 | 119331 | 58 | 70809050 |
Botryomycosis | 14.30 | 12.49 | 5 | 119331 | 59 | 70809049 |
Crying | 14.28 | 12.49 | 9 | 119327 | 21190 | 70787918 |
Pharyngeal ulceration | 14.26 | 12.49 | 12 | 119324 | 896 | 70808212 |
Hypothalamo-pituitary disorder | 14.24 | 12.49 | 13 | 119323 | 1082 | 70808026 |
Onychoclasis | 14.15 | 12.49 | 28 | 119308 | 4956 | 70804152 |
Gastroenteropancreatic neuroendocrine tumour disease | 14.15 | 12.49 | 5 | 119331 | 61 | 70809047 |
Scleroderma-like reaction | 14.13 | 12.49 | 6 | 119330 | 123 | 70808985 |
Adenocarcinoma gastric | 14.13 | 12.49 | 16 | 119320 | 1720 | 70807388 |
Heart rate decreased | 14.13 | 12.49 | 55 | 119281 | 61960 | 70747148 |
Abdominal fat apron | 14.09 | 12.49 | 3 | 119333 | 3 | 70809105 |
Metaplastic breast carcinoma | 14.09 | 12.49 | 3 | 119333 | 3 | 70809105 |
Increased liver stiffness | 14.09 | 12.49 | 3 | 119333 | 3 | 70809105 |
Schistosomiasis | 14.07 | 12.49 | 5 | 119331 | 62 | 70809046 |
Adrenal insufficiency | 14.03 | 12.49 | 13 | 119323 | 25182 | 70783926 |
Cerebrovascular accident | 14.02 | 12.49 | 164 | 119172 | 143306 | 70665802 |
Herpes zoster | 13.96 | 12.49 | 85 | 119251 | 85150 | 70723958 |
Insulinoma | 13.91 | 12.49 | 6 | 119330 | 128 | 70808980 |
Electrolyte imbalance | 13.90 | 12.49 | 85 | 119251 | 26776 | 70782332 |
Sinus congestion | 13.73 | 12.49 | 6 | 119330 | 17367 | 70791741 |
Pituitary tumour | 13.69 | 12.49 | 13 | 119323 | 1138 | 70807970 |
Dyspnoea | 13.66 | 12.49 | 1113 | 118223 | 768947 | 70040161 |
Administration site extravasation | 13.65 | 12.49 | 13 | 119323 | 1142 | 70807966 |
Bronchiectasis | 13.64 | 12.49 | 5 | 119331 | 16092 | 70793016 |
Radioisotope scan | 13.63 | 12.49 | 3 | 119333 | 4 | 70809104 |
Ureteric obstruction | 13.63 | 12.49 | 19 | 119317 | 2520 | 70806588 |
Hypothyroidism | 13.63 | 12.49 | 36 | 119300 | 45719 | 70763389 |
Influenza like illness | 13.61 | 12.49 | 60 | 119276 | 65271 | 70743837 |
Limb injury | 13.52 | 12.49 | 14 | 119322 | 25738 | 70783370 |
Lung neoplasm malignant | 13.50 | 12.49 | 13 | 119323 | 24729 | 70784379 |
Kidney infection | 13.46 | 12.49 | 8 | 119328 | 19447 | 70789661 |
Actinomycosis | 13.44 | 12.49 | 12 | 119324 | 971 | 70808137 |
Genital erythema | 13.40 | 12.49 | 7 | 119329 | 232 | 70808876 |
Cheilitis | 13.37 | 12.49 | 27 | 119309 | 4850 | 70804258 |
Diffuse large B-cell lymphoma | 13.35 | 12.49 | 3 | 119333 | 13299 | 70795809 |
Blood lactate dehydrogenase increased | 13.32 | 12.49 | 103 | 119233 | 35024 | 70774084 |
Pelvic venous thrombosis | 13.29 | 12.49 | 16 | 119320 | 1836 | 70807272 |
Nail toxicity | 13.25 | 12.49 | 8 | 119328 | 352 | 70808756 |
Abdominal wall oedema | 13.23 | 12.49 | 3 | 119333 | 5 | 70809103 |
Short-bowel syndrome | 13.19 | 12.49 | 9 | 119327 | 490 | 70808618 |
Neutrophilia | 13.14 | 12.49 | 34 | 119302 | 7187 | 70801921 |
Subclavian vein thrombosis | 13.09 | 12.49 | 18 | 119318 | 2356 | 70806752 |
Metastases to bladder | 13.08 | 12.49 | 7 | 119329 | 244 | 70808864 |
Pleural neoplasm | 13.07 | 12.49 | 8 | 119328 | 361 | 70808747 |
Dermatomyositis | 13.00 | 12.49 | 22 | 119314 | 3453 | 70805655 |
Tumour excision | 13.00 | 12.49 | 9 | 119327 | 502 | 70808606 |
Hepatic cancer metastatic | 12.97 | 12.49 | 11 | 119325 | 830 | 70808278 |
Hemianopia | 12.97 | 12.49 | 15 | 119321 | 1650 | 70807458 |
Skin sensitisation | 12.95 | 12.49 | 11 | 119325 | 832 | 70808276 |
Illness | 12.86 | 12.49 | 21 | 119315 | 31770 | 70777338 |
Renal tubular necrosis | 12.85 | 12.49 | 12 | 119324 | 23159 | 70785949 |
Sequestrectomy | 12.84 | 12.49 | 11 | 119325 | 842 | 70808266 |
Haematemesis | 12.79 | 12.49 | 132 | 119204 | 48665 | 70760443 |
Portal vein thrombosis | 12.74 | 12.49 | 28 | 119308 | 5334 | 70803774 |
Rash maculo-papular | 12.73 | 12.49 | 43 | 119293 | 50502 | 70758606 |
Haemolytic anaemia | 12.70 | 12.49 | 59 | 119277 | 16735 | 70792373 |
Urinary incontinence | 12.67 | 12.49 | 28 | 119308 | 37814 | 70771294 |
Pancreatic carcinoma metastatic | 12.67 | 12.49 | 23 | 119313 | 3817 | 70805291 |
Proctitis | 12.62 | 12.49 | 22 | 119314 | 3536 | 70805572 |
Miosis | 12.61 | 12.49 | 4 | 119332 | 14097 | 70795011 |
Gastric disorder | 12.58 | 12.49 | 23 | 119313 | 33299 | 70775809 |
Jaundice cholestatic | 12.56 | 12.49 | 39 | 119297 | 9145 | 70799963 |
Congenital haematological disorder | 12.51 | 12.49 | 4 | 119332 | 35 | 70809073 |
Skin burning sensation | 12.50 | 12.49 | 45 | 119291 | 11381 | 70797727 |
Squamous cell carcinoma of skin | 12.50 | 12.49 | 3 | 119333 | 12709 | 70796399 |
None
Source | Code | Description |
---|---|---|
ATC | L01BC06 | ANTINEOPLASTIC AND IMMUNOMODULATING AGENTS ANTINEOPLASTIC AGENTS ANTIMETABOLITES Pyrimidine analogues |
FDA MoA | N0000000233 | Nucleic Acid Synthesis Inhibitors |
FDA EPC | N0000175595 | Nucleoside Metabolic Inhibitor |
MeSH PA | D000963 | Antimetabolites |
MeSH PA | D000964 | Antimetabolites, Antineoplastic |
MeSH PA | D000970 | Antineoplastic Agents |
MeSH PA | D009676 | Noxae |
CHEBI has role | CHEBI:35221 | antimetabolite |
CHEBI has role | CHEBI:35610 | antineoplastic agents |
CHEBI has role | CHEBI:50266 | Prodrugs |
Disease | Relation | SNOMED_ID | DOID |
---|---|---|---|
Metastasis from malignant tumor of colon | indication | 314998002 | |
Malignant tumor of stomach | indication | 363349007 | DOID:10534 |
Metastatic Breast Carcinoma | indication | ||
Lymph Node Positive Colorectal Carcinoma | indication | ||
Malignant tumor of ovary | off-label use | 363443007 | DOID:2394 |
Adenocarcinoma of pancreas | off-label use | 700423003 | DOID:4074 |
Pancreatic Neuroendocrine Tumor | off-label use | 717919005 | |
Necrotizing enterocolitis in fetus OR newborn | contraindication | 2707005 | |
Hyperbilirubinemia | contraindication | 14783006 | DOID:2741 |
Infectious disease | contraindication | 40733004 | |
Conduction disorder of the heart | contraindication | 44808001 | |
Acute nephropathy | contraindication | 58574008 | |
Stomatitis | contraindication | 61170000 | DOID:9637 |
Dihydrouracil dehydrogenase (NADP^+^) deficiency | contraindication | 77365006 | DOID:14218 |
Impaired renal function disorder | contraindication | 197663003 | |
Disease of liver | contraindication | 235856003 | DOID:409 |
Anemia | contraindication | 271737000 | DOID:2355 |
Pregnancy, function | contraindication | 289908002 | |
Thrombocytopenic disorder | contraindication | 302215000 | DOID:1588 |
Neutropenic disorder | contraindication | 303011007 | DOID:1227 |
Severe diarrhea | contraindication | 409587002 | |
Breastfeeding (mother) | contraindication | 413712001 | |
Disorder of coronary artery | contraindication | 414024009 | |
Palmar-Plantar Erythrodysesthesia | contraindication |
None
None
Dissociation level | Dissociation constant | Type (acidic/basic) |
---|---|---|
pKa1 | 12.3 | acidic |
pKa2 | 12.91 | acidic |
pKa3 | 13.46 | acidic |
pKa4 | 0.75 | Basic |
None
None
Target | Class | Pharos | UniProt | Action | Type | Activity value (-log[M]) | Mechanism action | Bioact source | MoA source |
---|---|---|---|---|---|---|---|---|---|
Thymidylate synthase | Enzyme | INHIBITOR | WOMBAT-PK | CHEMBL |
ID | Source |
---|---|
4021099 | VUID |
N0000148555 | NUI |
D01223 | KEGG_DRUG |
194000 | RXNORM |
4021099 | VANDF |
C0671970 | UMLSCUI |
CHEBI:31348 | CHEBI |
CHEMBL1773 | ChEMBL_ID |
DB01101 | DRUGBANK_ID |
D000069287 | MESH_DESCRIPTOR_UI |
60953 | PUBCHEM_CID |
6799 | IUPHAR_LIGAND_ID |
7317 | INN_ID |
6804DJ8Z9U | UNII |
11693 | MMSL |
210675 | MMSL |
4344 | MMSL |
d04311 | MMSL |
007533 | NDDF |
108761006 | SNOMEDCT_US |
386906001 | SNOMEDCT_US |
Product | Category | Ingredients | NDC | Form | Quantity | Route | Marketing | Label |
---|---|---|---|---|---|---|---|---|
Xeloda | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0004-1100 | TABLET, FILM COATED | 150 mg | ORAL | NDA | 29 sections |
Xeloda | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0004-1101 | TABLET, FILM COATED | 500 mg | ORAL | NDA | 29 sections |
Capecitabine | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0054-0271 | TABLET, FILM COATED | 150 mg | ORAL | ANDA | 28 sections |
Capecitabine | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0054-0271 | TABLET, FILM COATED | 150 mg | ORAL | ANDA | 28 sections |
Capecitabine | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0054-0271 | TABLET, FILM COATED | 150 mg | ORAL | ANDA | 28 sections |
Capecitabine | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0054-0272 | TABLET, FILM COATED | 500 mg | ORAL | ANDA | 28 sections |
Capecitabine | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0054-0272 | TABLET, FILM COATED | 500 mg | ORAL | ANDA | 28 sections |
Capecitabine | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0054-0272 | TABLET, FILM COATED | 500 mg | ORAL | ANDA | 28 sections |
Capecitabine | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0093-7473 | TABLET, FILM COATED | 150 mg | ORAL | ANDA | 28 sections |
Capecitabine | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0093-7474 | TABLET, FILM COATED | 500 mg | ORAL | ANDA | 28 sections |
Capecitabine | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0378-2511 | TABLET, FILM COATED | 150 mg | ORAL | ANDA | 29 sections |
Capecitabine | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0378-2512 | TABLET, FILM COATED | 500 mg | ORAL | ANDA | 29 sections |
CAPECITABINE | HUMAN PRESCRIPTION DRUG LABEL | 1 | 16714-467 | TABLET, FILM COATED | 150 mg | ORAL | ANDA | 27 sections |
CAPECITABINE | HUMAN PRESCRIPTION DRUG LABEL | 1 | 16714-468 | TABLET, FILM COATED | 500 mg | ORAL | ANDA | 27 sections |
CAPECITABINE | HUMAN PRESCRIPTION DRUG LABEL | 1 | 16729-072 | TABLET, FILM COATED | 150 mg | ORAL | ANDA | 28 sections |
CAPECITABINE | HUMAN PRESCRIPTION DRUG LABEL | 1 | 16729-073 | TABLET, FILM COATED | 500 mg | ORAL | ANDA | 28 sections |
Capecitabine | HUMAN PRESCRIPTION DRUG LABEL | 1 | 50268-154 | TABLET | 500 mg | ORAL | ANDA | 21 sections |
Capecitabine | HUMAN PRESCRIPTION DRUG LABEL | 1 | 51079-510 | TABLET, FILM COATED | 500 mg | ORAL | ANDA | 29 sections |
Capecitabine | HUMAN PRESCRIPTION DRUG LABEL | 1 | 51407-095 | TABLET, FILM COATED | 150 mg | ORAL | ANDA | 28 sections |
Capecitabine | HUMAN PRESCRIPTION DRUG LABEL | 1 | 51407-095 | TABLET, FILM COATED | 150 mg | ORAL | ANDA | 28 sections |
Capecitabine | HUMAN PRESCRIPTION DRUG LABEL | 1 | 51407-096 | TABLET, FILM COATED | 500 mg | ORAL | ANDA | 28 sections |
Capecitabine | HUMAN PRESCRIPTION DRUG LABEL | 1 | 51407-096 | TABLET, FILM COATED | 500 mg | ORAL | ANDA | 28 sections |
Capecitabine | HUMAN PRESCRIPTION DRUG LABEL | 1 | 51407-639 | TABLET, FILM COATED | 150 mg | ORAL | ANDA | 28 sections |
Capecitabine | HUMAN PRESCRIPTION DRUG LABEL | 1 | 51407-640 | TABLET, FILM COATED | 500 mg | ORAL | ANDA | 28 sections |
Xeloda | HUMAN PRESCRIPTION DRUG LABEL | 1 | 53808-0411 | TABLET, FILM COATED | 500 mg | ORAL | NDA | 24 sections |
Xeloda | HUMAN PRESCRIPTION DRUG LABEL | 1 | 54868-4143 | TABLET, FILM COATED | 150 mg | ORAL | NDA | 30 sections |
Xeloda | HUMAN PRESCRIPTION DRUG LABEL | 1 | 54868-5260 | TABLET, FILM COATED | 500 mg | ORAL | NDA | 30 sections |
capecitabine | HUMAN PRESCRIPTION DRUG LABEL | 1 | 55111-496 | TABLET | 150 mg | ORAL | ANDA | 26 sections |
capecitabine | HUMAN PRESCRIPTION DRUG LABEL | 1 | 55111-497 | TABLET | 500 mg | ORAL | ANDA | 26 sections |
Capecitabine | Human Prescription Drug Label | 1 | 59651-204 | TABLET | 150 mg | ORAL | ANDA | 28 sections |