somatrem 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
growth hormone derivatives 5042 82030-87-3

Description:

MoleculeDescription

Synonyms:

  • somatrem
  • somatrem (genetical recombination)
  • methionyl human growth hormone
  • protropin
  • somatonorm
was MH (1997-2002), demoted; an analog of the synthetic human growth hormone (human somatropin) in which a methionyl amino-acid residue is added. It may be produced in bacteria from recombinant DNA. It is used in therapy for growth hormone deficiency. Do not confuse somatrem with sometribove (methionyl bovine somatotropin).
  • Molecular weight:
  • Formula:
  • CLOGP:
  • LIPINSKI: None
  • HAC: None
  • HDO: None
  • TPSA:
  • ALOGS:
  • ROTB: None

Drug dosage:

None

ADMET properties:

None

Approvals:

DateAgencyCompanyOrphan
Oct. 17, 1985 FDA GENENTECH

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Clear cell renal cell carcinoma 223.21 90.92 30 174 985 29573338
Lymphoproliferative disorder 195.86 90.92 30 174 2497 29571826

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Clear cell renal cell carcinoma 235.18 77.38 31 156 2148 64496397
Lymphoproliferative disorder 208.81 77.38 31 156 5072 64493473
Renal cell carcinoma 79.98 77.38 14 173 6090 64492455

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
ATC H01AC02 SYSTEMIC HORMONAL PREPARATIONS, EXCL. SEX HORMONES AND INSULINS
PITUITARY AND HYPOTHALAMIC HORMONES AND ANALOGUES
ANTERIOR PITUITARY LOBE HORMONES AND ANALOGUES
Somatropin and somatropin agonists

Drug Use (View source of the data)

DiseaseRelationSNOMED_IDDOID
Pituitary dwarfism indication 367460001 DOID:0060870
Growth retardation indication 444896005




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

None

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
Growth hormone receptor GPCR AGONIST SCIENTIFIC LITERATURE SCIENTIFIC LITERATURE

External reference:

IDSource
CU8D464EDW UNII
D05884 KEGG_DRUG
4019548 VUID
N0000147652 NUI
4019548 VANDF
C0143083 UMLSCUI
CHEMBL1201620 ChEMBL_ID
DB09098 DRUGBANK_ID
5528 INN_ID
C447442 MESH_SUPPLEMENTAL_RECORD_UI
202986 RXNORM
3666 MMSL
5500 MMSL
d00576 MMSL
109052005 SNOMEDCT_US
125578008 SNOMEDCT_US
002105 NDDF

Pharmaceutical products:

None