somatropin 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | PK/Tox | Related Drugs | BioActivity |

Stem definitionDrug idCAS RN
growth hormone derivatives 4848 12629-01-5

Description:

MoleculeDescription

Synonyms:

  • somatropin
  • somatropine
  • human growth hormone
  • somatotropin (human)
  • omnitrope
  • somatropin recombinant
  • somatropin [rDNA origin]
A 191-amino acid polypeptide hormone secreted by the human adenohypophysis (PITUITARY GLAND, ANTERIOR), also known as GH or somatotropin. Synthetic growth hormone, termed somatropin, has replaced the natural form in therapeutic usage such as treatment of dwarfism in children with growth hormone deficiency.
  • Molecular weight: 22125.07
  • Formula: C990H1528N262O300S7
  • CLOGP:
  • LIPINSKI: None
  • HAC: None
  • HDO: None
  • TPSA: 9147.67
  • ALOGS:
  • ROTB: None

Drug dosage:

DoseUnitRoute
2 U P

ADMET properties:

None

Predicted pharmacokinetic/toxicological properties (PK-AZ):

None

Approvals:

DateAgencyCompanyOrphan
July 30, 1976 FDA SERONO
April 12, 2006 EMA SANDOZ GMBH
June 22, 2009 PMDA Sandoz K.K.

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Drug dose omission by device 5407.40 20.68 1098 25514 9133 90592702
Device leakage 2903.90 20.68 656 25956 9335 90592500
Device mechanical issue 2759.17 20.68 444 26168 679 90601156
Device information output issue 2457.96 20.68 354 26258 77 90601758
Device breakage 2121.53 20.68 544 26068 13500 90588335
Wrong technique in device usage process 1780.44 20.68 399 26213 5436 90596399
Device issue 1071.45 20.68 381 26231 29156 90572679
Poor quality device used 928.80 20.68 198 26414 2095 90599740
Device physical property issue 744.54 20.68 171 26441 2605 90599230
Device use error 666.92 20.68 190 26422 7031 90594804
Device delivery system issue 666.15 20.68 144 26468 1634 90600201
Insulin-like growth factor increased 659.99 20.68 129 26483 845 90600990
Device use issue 649.77 20.68 162 26450 3551 90598284
Incorrect dose administered by device 621.27 20.68 171 26441 5566 90596269
Expired device used 606.87 20.68 116 26496 664 90601171
Product dose omission issue 596.63 20.68 568 26044 291119 90310716
Device defective 535.21 20.68 137 26475 3349 90598486
Insulin-like growth factor decreased 518.60 20.68 92 26520 320 90601515
Device power source issue 516.10 20.68 103 26509 761 90601074
Device malfunction 458.02 20.68 187 26425 20790 90581045
Product prescribing error 442.48 20.68 203 26409 29942 90571893
Injection site pain 436.19 20.68 380 26232 173319 90428516
Incorrect dose administered 335.71 20.68 236 26376 78694 90523141
Liquid product physical issue 267.99 20.68 67 26545 1483 90600352
Craniopharyngioma 255.79 20.68 44 26568 121 90601714
Blood thyroid stimulating hormone decreased 250.07 20.68 85 26527 5655 90596180
Device material issue 237.32 20.68 48 26564 382 90601453
Scoliosis 231.21 20.68 90 26522 8817 90593018
Growth retardation 229.83 20.68 61 26551 1722 90600113
Device difficult to use 199.05 20.68 99 26513 17426 90584409
Device failure 190.81 20.68 73 26539 6824 90595011
Injection site bruising 187.26 20.68 141 26471 52166 90549669
Headache 160.02 20.68 585 26027 862161 89739674
Product storage error 157.94 20.68 89 26523 20152 90581683
Injection site haemorrhage 154.70 20.68 99 26513 28219 90573616
Epiphysiolysis 149.23 20.68 24 26588 36 90601799
Adenoidal hypertrophy 140.66 20.68 25 26587 88 90601747
Device occlusion 137.64 20.68 63 26549 9219 90592616
Snoring 137.31 20.68 53 26559 5073 90596762
Drug administered in wrong device 135.25 20.68 22 26590 37 90601798
Circumstance or information capable of leading to device use error 128.86 20.68 26 26586 204 90601631
Product communication issue 122.97 20.68 36 26576 1465 90600370
Exposure via skin contact 117.20 20.68 59 26553 10646 90591189
Blood glucose increased 115.31 20.68 141 26471 95105 90506730
Sleep apnoea syndrome 114.52 20.68 86 26526 31661 90570174
Blood 25-hydroxycholecalciferol decreased 110.71 20.68 20 26592 79 90601756
Blood triglycerides increased 108.68 20.68 61 26551 13700 90588135
Brain neoplasm 108.28 20.68 44 26568 4820 90597015
Needle issue 105.28 20.68 60 26552 13874 90587961
Infusion related reaction 104.96 20.68 4 26608 416776 90185059
Low density lipoprotein increased 101.75 20.68 49 26563 8036 90593799
Non-high-density lipoprotein cholesterol increased 101.41 20.68 21 26591 190 90601645
Adrenocortical insufficiency acute 95.84 20.68 34 26578 2567 90599268
Dyspnoea 95.26 20.68 72 26540 880883 89720952
Thyroxine free decreased 95.12 20.68 26 26586 822 90601013
Hepatic necrosis 93.27 20.68 43 26569 6395 90595440
Glycosylated haemoglobin increased 91.47 20.68 57 26555 15505 90586330
Hepatic enzyme increased 89.02 20.68 4 26608 360732 90241103
Rheumatoid arthritis 86.38 20.68 5 26607 362609 90239226
No adverse event 86.10 20.68 103 26509 67879 90533956
Wrong technique in product usage process 85.06 20.68 105 26507 71466 90530369
Circumstance or information capable of leading to medication error 84.12 20.68 37 26575 4930 90596905
Blood creatinine decreased 83.55 20.68 40 26572 6475 90595360
Accidental exposure to product 83.28 20.68 81 26531 42285 90559550
Wound 75.94 20.68 3 26609 302977 90298858
Blood urea nitrogen/creatinine ratio increased 74.65 20.68 23 26589 1116 90600719
Tonsillar disorder 73.43 20.68 23 26589 1179 90600656
Blood growth hormone decreased 72.10 20.68 12 26600 25 90601810
Papilloedema 70.55 20.68 32 26580 4583 90597252
Tonsillar hypertrophy 69.82 20.68 22 26590 1150 90600685
High density lipoprotein decreased 69.54 20.68 27 26585 2624 90599211
Toxicity to various agents 68.44 20.68 4 26608 287842 90313993
Poor quality product administered 68.34 20.68 30 26582 3978 90597857
Vitamin D decreased 68.20 20.68 43 26569 11936 90589899
Drug hypersensitivity 67.32 20.68 26 26586 463583 90138252
Abdominal discomfort 67.30 20.68 28 26584 477300 90124535
Cerebral salt-wasting syndrome 65.99 20.68 15 26597 217 90601618
Drug intolerance 65.15 20.68 25 26587 447566 90154269
Idiopathic intracranial hypertension 64.96 20.68 28 26584 3553 90598282
Stomatitis 64.76 20.68 4 26608 274694 90327141
Seizure 64.45 20.68 140 26472 152489 90449346
Septo-optic dysplasia 64.20 20.68 9 26603 0 90601835
Drug ineffective 63.32 20.68 203 26409 1384095 89217740
Arthropathy 63.16 20.68 15 26597 366227 90235608
Hepatic encephalopathy 62.72 20.68 43 26569 13729 90588106
Wrong device used 62.51 20.68 11 26601 36 90601799
Confusional state 62.45 20.68 18 26594 386187 90215648
Blister 62.32 20.68 3 26609 254995 90346840
Pruritus 61.36 20.68 42 26570 541483 90060352
Pituitary tumour recurrent 60.43 20.68 12 26600 86 90601749
Blood thyroid stimulating hormone increased 60.12 20.68 36 26576 9119 90592716
Meningioma 58.61 20.68 29 26583 5042 90596793
Growing pains 58.54 20.68 10 26602 26 90601809
Bone density increased 58.07 20.68 18 26594 891 90600944
Cortisol decreased 57.33 20.68 21 26591 1738 90600097
Psoriatic arthropathy 54.81 20.68 3 26609 228332 90373503
Rash 52.69 20.68 96 26516 796004 89805831
Product reconstitution quality issue 52.40 20.68 11 26601 107 90601728
Mood altered 52.16 20.68 42 26570 17102 90584733
Blood follicle stimulating hormone increased 51.96 20.68 12 26600 187 90601648
Thyroxine free increased 51.85 20.68 17 26595 1010 90600825
Helicobacter infection 51.44 20.68 4 26608 226846 90374989
General physical health deterioration 51.38 20.68 20 26592 355095 90246740
Joint swelling 50.68 20.68 44 26568 503256 90098579
Intracranial pressure increased 50.56 20.68 29 26583 6782 90595053
Blood glucose decreased 50.22 20.68 47 26565 23382 90578453
Acute kidney injury 49.85 20.68 16 26596 320371 90281464
Increased appetite 49.52 20.68 35 26577 11730 90590105
Acromegaly 47.95 20.68 10 26602 94 90601741
Nausea 47.79 20.68 167 26445 1110149 89491686
Therapeutic product effect decreased 46.61 20.68 12 26600 277559 90324276
Hypopituitarism 46.50 20.68 18 26594 1735 90600100
Impaired healing 45.85 20.68 7 26605 234192 90367643
Pituitary tumour 45.38 20.68 15 26597 914 90600921
Device electrical finding 44.72 20.68 11 26601 227 90601608
Astrocytoma 44.34 20.68 9 26603 73 90601762
Mobility decreased 43.74 20.68 10 26602 250724 90351111
Lower respiratory tract infection 43.72 20.68 10 26602 250649 90351186
Diarrhoea 43.30 20.68 137 26475 939053 89662782
Albumin globulin ratio increased 42.75 20.68 8 26604 40 90601795
Musculoskeletal stiffness 42.40 20.68 17 26595 296515 90305320
Intercepted product prescribing error 41.90 20.68 11 26601 297 90601538
Medulloblastoma recurrent 41.46 20.68 9 26603 104 90601731
Therapeutic response unexpected 41.44 20.68 41 26571 21839 90579996
Blood alkaline phosphatase decreased 41.39 20.68 16 26596 1537 90600298
Glucose tolerance impaired 41.34 20.68 27 26585 7958 90593877
Therapy cessation 41.03 20.68 52 26560 36309 90565526
Hyponatraemic seizure 40.76 20.68 12 26600 498 90601337
Neutrophilic panniculitis 40.70 20.68 8 26604 54 90601781
Exposure during pregnancy 40.61 20.68 10 26602 238400 90363435
Blood corticotrophin decreased 40.04 20.68 12 26600 530 90601305
Epiphyses premature fusion 39.85 20.68 8 26604 61 90601774
Pituitary tumour benign 39.76 20.68 17 26595 2115 90599720
Blood prolactin decreased 39.51 20.68 8 26604 64 90601771
Product dispensing error 39.33 20.68 31 26581 12242 90589593
Thyroxine increased 39.22 20.68 13 26599 799 90601036
Medulloblastoma 39.18 20.68 8 26604 67 90601768
Pain 38.82 20.68 156 26456 996185 89605650
Osteochondrosis 38.73 20.68 16 26596 1827 90600008
Infection 38.48 20.68 30 26582 362064 90239771
Osteoarthritis 37.97 20.68 6 26606 195724 90406111
Cortisol increased 36.50 20.68 11 26601 495 90601340
Energy increased 36.47 20.68 18 26594 3112 90598723
Device operational issue 36.45 20.68 13 26599 997 90600838
Blood urea decreased 36.04 20.68 17 26595 2661 90599174
Focal nodular hyperplasia 35.86 20.68 12 26600 760 90601075
Hypotension 35.80 20.68 26 26586 325371 90276464
Discomfort 35.66 20.68 18 26594 274317 90327518
Temperature intolerance 35.60 20.68 29 26583 12001 90589834
Alveolar rhabdomyosarcoma 35.29 20.68 6 26606 15 90601820
Product preparation issue 35.02 20.68 16 26596 2330 90599505
Reaction to preservatives 34.76 20.68 9 26603 230 90601605
Gastrointestinal disorder 34.64 20.68 16 26596 256671 90345164
Anaemia 34.10 20.68 32 26580 352770 90249065
Menstruation irregular 33.97 20.68 24 26588 8036 90593799
Hair growth abnormal 33.74 20.68 18 26594 3658 90598177
Pneumonia 33.05 20.68 88 26524 637971 89963864
Blood insulin increased 32.86 20.68 8 26604 158 90601677
Osteochondroma 32.73 20.68 5 26607 4 90601831
Injury 32.23 20.68 9 26603 197340 90404495
Growth hormone deficiency 32.08 20.68 8 26604 175 90601660
Swelling 31.90 20.68 46 26566 419012 90182823
Hepatotoxicity 31.76 20.68 52 26560 45790 90556045
Hypersensitivity 31.67 20.68 53 26559 454624 90147211
Tri-iodothyronine free increased 30.27 20.68 8 26604 222 90601613
Blood chloride increased 30.25 20.68 16 26596 3194 90598641
Neoplasm recurrence 30.03 20.68 16 26596 3243 90598592
Tri-iodothyronine decreased 29.96 20.68 8 26604 231 90601604
Hypothalamo-pituitary disorder 29.40 20.68 14 26598 2238 90599597
Hypoglycaemia 29.38 20.68 64 26548 69784 90532051
Aortic valve disease 29.36 20.68 12 26600 1334 90600501
Carbon dioxide decreased 29.34 20.68 15 26597 2793 90599042
Product solubility abnormal 29.27 20.68 11 26601 978 90600857
Fibromyalgia 29.19 20.68 12 26600 206257 90395578
Hormone level abnormal 29.02 20.68 15 26597 2858 90598977
Acral overgrowth 28.53 20.68 4 26608 0 90601835
Very low density lipoprotein increased 28.48 20.68 7 26605 144 90601691
Otitis media 28.33 20.68 19 26593 5851 90595984
Precocious puberty 27.63 20.68 8 26604 313 90601522
Blood sodium increased 27.58 20.68 15 26597 3167 90598668
Electric shock sensation 27.57 20.68 12 26600 1558 90600277
Diabetes insipidus 27.45 20.68 15 26597 3197 90598638
Gastrointestinal infection 27.39 20.68 24 26588 10966 90590869
Product contamination 27.35 20.68 11 26601 1173 90600662
Dyspepsia 27.28 20.68 12 26600 198148 90403687
Injection site mass 27.18 20.68 33 26579 22057 90579778
Device dispensing error 26.85 20.68 7 26605 184 90601651
Lymphocyte count increased 26.75 20.68 16 26596 4043 90597792
Thrombocytopenia 26.66 20.68 14 26598 208711 90393124
C-reactive protein increased 26.57 20.68 10 26602 181379 90420456
Anion gap increased 26.29 20.68 13 26599 2257 90599578
Wheezing 26.21 20.68 19 26593 238061 90363774
Syringomyelia 25.96 20.68 7 26605 210 90601625
Breast discomfort 25.85 20.68 9 26603 643 90601192
Total cholesterol/HDL ratio increased 25.74 20.68 7 26605 217 90601618
Dry mouth 25.57 20.68 11 26601 184048 90417787
Infantile haemangioma 25.49 20.68 6 26606 102 90601733
Irritability 25.45 20.68 41 26571 35621 90566214
Haematocrit increased 25.27 20.68 14 26598 3064 90598771
Disease recurrence 25.13 20.68 42 26570 37611 90564224
Oestradiol decreased 25.11 20.68 6 26606 109 90601726
Alopecia 25.06 20.68 69 26543 495002 90106833
Maternal exposure during pregnancy 25.03 20.68 42 26570 360021 90241814
Pancytopenia 24.94 20.68 3 26609 120260 90481575
Neutropenia 24.69 20.68 18 26594 224886 90376949
Weight increased 24.61 20.68 208 26404 417719 90184116
Adverse event 24.17 20.68 3 26609 117415 90484420
Lung disorder 24.17 20.68 7 26605 149876 90451959
Oesophageal disorder 24.10 20.68 13 26599 2700 90599135
Weight gain poor 24.04 20.68 10 26602 1162 90600673
Blood albumin increased 23.93 20.68 10 26602 1175 90600660
Blood alkaline phosphatase increased 23.67 20.68 47 26565 48032 90553803
Mean cell volume increased 23.63 20.68 16 26596 5005 90596830
Adenoidectomy 23.45 20.68 6 26606 146 90601689
Product use issue 23.38 20.68 38 26574 329881 90271954
Condition aggravated 23.28 20.68 93 26519 595452 90006383
Urine output increased 23.15 20.68 11 26601 1751 90600084
Platelet count decreased 22.83 20.68 6 26606 136963 90464872
Total cholesterol/HDL ratio decreased 22.52 20.68 4 26608 14 90601821
Nail bed disorder 22.44 20.68 7 26605 354 90601481
Therapy interrupted 22.32 20.68 47 26565 50061 90551774
Blood follicle stimulating hormone decreased 22.31 20.68 4 26608 15 90601820
Growth accelerated 22.10 20.68 4 26608 16 90601819
Germ cell cancer 22.02 20.68 5 26607 72 90601763
Mycobacterium chelonae infection 21.99 20.68 8 26604 649 90601186
Atrial fibrillation 21.99 20.68 6 26606 133605 90468230
Blood testosterone decreased 21.95 20.68 5 26607 73 90601762
Growth failure 21.92 20.68 7 26605 382 90601453
Product physical issue 21.90 20.68 16 26596 5644 90596191
Thyroxine decreased 21.67 20.68 8 26604 677 90601158
Globulins decreased 21.56 20.68 7 26605 403 90601432
Hypertension 21.53 20.68 66 26546 457466 90144369
Rathke's cleft cyst 21.40 20.68 3 26609 0 90601835
Noonan syndrome 21.40 20.68 3 26609 0 90601835
Non-secretory adenoma of pituitary 21.40 20.68 3 26609 0 90601835
Device chemical property issue 21.40 20.68 3 26609 0 90601835
Blood testosterone free decreased 21.40 20.68 3 26609 0 90601835
Habit cough 21.40 20.68 3 26609 0 90601835
Perthes disease 21.40 20.68 3 26609 0 90601835
Bilateral breast buds 21.40 20.68 3 26609 0 90601835
Ill-defined disorder 21.35 20.68 14 26598 184877 90416958
Product odour abnormal 21.23 20.68 10 26602 1561 90600274
Glioma 21.06 20.68 7 26605 434 90601401
Astrocytoma, low grade 21.05 20.68 4 26608 22 90601813
Venous injury 20.88 20.68 8 26604 750 90601085
Liver disorder 20.81 20.68 5 26607 121264 90480571
Breast swelling 20.74 20.68 10 26602 1644 90600191

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Drug dose omission by device 9454.92 20.50 1899 33953 3987 42581496
Device breakage 5165.76 20.50 1062 34790 2587 42582896
Device leakage 4603.84 20.50 1171 34681 9114 42576369
Device mechanical issue 4107.21 20.50 724 35128 377 42585106
Device information output issue 3744.73 20.50 622 35230 45 42585438
Wrong technique in device usage process 2998.86 20.50 646 35206 2111 42583372
Device issue 2021.78 20.50 656 35196 12853 42572630
Poor quality device used 1957.64 20.50 401 35451 940 42584543
Device use error 1555.78 20.50 390 35462 2807 42582676
Device physical property issue 1550.20 20.50 337 35515 1157 42584326
Incorrect dose administered by device 1384.90 20.50 345 35507 2411 42583072
Device use issue 1236.97 20.50 260 35592 723 42584760
Device delivery system issue 1183.27 20.50 253 35599 784 42584699
Insulin-like growth factor increased 1179.76 20.50 274 35578 1357 42584126
Device defective 1024.32 20.50 246 35606 1442 42584041
Injection site pain 873.21 20.50 565 35287 57233 42528250
Device power source issue 822.13 20.50 171 35681 443 42585040
Device malfunction 754.92 20.50 310 35542 12017 42573466
Product dose omission issue 750.67 20.50 778 35074 153587 42431896
Expired device used 735.78 20.50 128 35724 51 42585432
Product prescribing error 667.56 20.50 359 35493 25753 42559730
Insulin-like growth factor decreased 629.74 20.50 120 35732 157 42585326
Device material issue 497.36 20.50 89 35763 57 42585426
Incorrect dose administered 438.09 20.50 360 35492 52614 42532869
Growth retardation 412.01 20.50 130 35722 2302 42583181
Device difficult to use 388.33 20.50 146 35706 4450 42581033
Device failure 352.72 20.50 119 35733 2624 42582859
Product storage error 323.75 20.50 167 35685 10973 42574510
Liquid product physical issue 306.90 20.50 81 35771 728 42584755
Craniopharyngioma 292.62 20.50 63 35789 203 42585280
Headache 279.98 20.50 619 35233 238750 42346733
Scoliosis 270.25 20.50 101 35751 3025 42582458
Injection site bruising 259.91 20.50 146 35706 11379 42574104
Bone density increased 235.19 20.50 45 35807 61 42585422
Circumstance or information capable of leading to device use error 235.19 20.50 45 35807 61 42585422
Needle issue 217.22 20.50 118 35734 8609 42576874
Acute kidney injury 192.39 20.50 38 35814 367299 42218184
Circumstance or information capable of leading to medication error 190.87 20.50 74 35778 2454 42583029
Product communication issue 190.81 20.50 60 35792 1049 42584434
Drug administered in wrong device 189.44 20.50 38 35814 76 42585407
Dyspnoea 180.01 20.50 74 35778 442547 42142936
Injection site haemorrhage 177.38 20.50 115 35737 11621 42573862
Toxicity to various agents 163.02 20.50 7 35845 229129 42356354
Blood thyroid stimulating hormone decreased 161.30 20.50 64 35788 2259 42583224
Epiphysiolysis 154.79 20.50 33 35819 100 42585383
Osteochondrosis 149.31 20.50 53 35799 1365 42584118
Adenoidal hypertrophy 148.42 20.50 34 35818 156 42585327
Pituitary tumour benign 146.90 20.50 48 35804 954 42584529
Pneumonia 146.75 20.50 87 35765 422062 42163421
No adverse event 145.99 20.50 172 35680 38849 42546634
Thyroxine free decreased 141.67 20.50 36 35816 274 42585209
Hypotension 136.09 20.50 26 35826 257605 42327878
Wrong device used 135.59 20.50 24 35828 13 42585470
Idiopathic intracranial hypertension 134.90 20.50 43 35809 787 42584696
Diarrhoea 131.53 20.50 117 35735 460732 42124751
Blood creatinine decreased 130.34 20.50 63 35789 3595 42581888
Drug interaction 128.82 20.50 33 35819 266966 42318517
Thrombocytopenia 125.47 20.50 9 35843 190270 42395213
Neutropenia 124.45 20.50 12 35840 199419 42386064
Device dispensing error 123.96 20.50 26 35826 71 42585412
Vitamin D decreased 123.45 20.50 65 35787 4450 42581033
Brain neoplasm 122.76 20.50 60 35792 3508 42581975
Anaemia 120.11 20.50 43 35809 280235 42305248
Blood urea nitrogen/creatinine ratio increased 119.92 20.50 34 35818 408 42585075
Exposure via skin contact 108.64 20.50 62 35790 4976 42580507
Sepsis 107.61 20.50 19 35833 199315 42386168
Papilloedema 103.39 20.50 52 35800 3234 42582249
Injection site discharge 101.25 20.50 31 35821 494 42584989
Epiphyses premature fusion 99.49 20.50 22 35830 83 42585400
Sleep apnoea syndrome 97.44 20.50 105 35747 21503 42563980
Glioneuronal tumour 97.31 20.50 16 35836 0 42585483
General physical health deterioration 91.98 20.50 10 35842 151236 42434247
Clear cell renal cell carcinoma 91.41 20.50 36 35816 1245 42584238
Blood testosterone increased 91.07 20.50 38 35814 1529 42583954
Confusional state 90.38 20.50 16 35836 167581 42417902
Poor quality product administered 89.08 20.50 42 35810 2266 42583217
Neoplasm recurrence 88.34 20.50 44 35808 2680 42582803
Weight gain poor 83.24 20.50 34 35818 1295 42584188
Wrong technique in product usage process 82.62 20.50 137 35715 42498 42542985
High density lipoprotein decreased 81.46 20.50 47 35805 3850 42581633
Hepatoblastoma 81.15 20.50 16 35836 28 42585455
Arthralgia 80.68 20.50 364 35488 204874 42380609
Intracranial pressure increased 78.58 20.50 49 35803 4625 42580858
Blood 25-hydroxycholecalciferol decreased 78.00 20.50 23 35829 320 42585163
Blood testosterone decreased 76.43 20.50 49 35803 4853 42580630
Thyroxine increased 76.33 20.50 18 35834 96 42585387
Drug ineffective 76.21 20.50 274 35578 629923 41955560
Atrial fibrillation 75.96 20.50 13 35839 139580 42445903
Device occlusion 75.14 20.50 60 35792 8390 42577093
Disease progression 72.64 20.50 16 35836 143640 42441843
Pancytopenia 71.03 20.50 8 35844 117735 42467748
Septo-optic dysplasia 70.31 20.50 12 35840 3 42585480
Respiratory failure 69.57 20.50 12 35840 128120 42457363
Growing pains 69.10 20.50 13 35839 15 42585468
Device electrical finding 67.77 20.50 17 35835 122 42585361
Device deployment issue 67.14 20.50 24 35828 631 42584852
Increased appetite 66.20 20.50 57 35795 8849 42576634
Nausea 65.90 20.50 148 35704 396651 42188832
Blood follicle stimulating hormone decreased 65.62 20.50 15 35837 68 42585415
Osteochondroma 65.18 20.50 12 35840 11 42585472
Snoring 65.15 20.50 41 35811 3932 42581551
Renal failure 65.06 20.50 20 35832 143706 42441777
Lymphoproliferative disorder 64.15 20.50 38 35814 3269 42582214
Pruritus 63.84 20.50 40 35812 188731 42396752
Accidental exposure to product 63.50 20.50 82 35770 20311 42565172
Blood luteinising hormone decreased 63.29 20.50 16 35836 119 42585364
Platelet count decreased 63.24 20.50 19 35833 138562 42446921
Acne 62.73 20.50 67 35785 13577 42571906
Product preparation issue 62.24 20.50 26 35826 1049 42584434
Pituitary tumour 61.99 20.50 22 35830 566 42584917
Injection site discomfort 61.94 20.50 33 35819 2313 42583170
Device operational issue 61.01 20.50 18 35834 251 42585232
Thyroxine decreased 59.73 20.50 17 35835 207 42585276
Focal segmental glomerulosclerosis 59.38 20.50 33 35819 2515 42582968
Product dispensing error 59.04 20.50 50 35802 7589 42577894
Skin odour abnormal 58.69 20.50 26 35826 1213 42584270
Precocious puberty 57.51 20.50 15 35837 128 42585355
Completed suicide 57.07 20.50 7 35845 96458 42489025
Underdose 56.63 20.50 70 35782 16596 42568887
Septic shock 55.86 20.50 6 35846 91666 42493817
Limb asymmetry 55.51 20.50 14 35838 103 42585380
Pleural effusion 55.22 20.50 8 35844 97158 42488325
Acromegaly 54.53 20.50 12 35840 44 42585439
Neuropathy peripheral 54.28 20.50 10 35842 101843 42483640
Glycosylated haemoglobin increased 53.40 20.50 60 35792 12864 42572619
Gastrointestinal haemorrhage 53.37 20.50 9 35843 97717 42487766
Blood thyroid stimulating hormone increased 52.30 20.50 40 35812 5252 42580231
Enuresis 51.80 20.50 31 35821 2717 42582766
Neurofibromatosis 51.28 20.50 10 35842 16 42585467
Product reconstitution quality issue 51.05 20.50 15 35837 206 42585277
Interstitial lung disease 50.84 20.50 4 35848 78458 42507025
Delayed puberty 50.39 20.50 15 35837 216 42585267
Cardiac failure 49.93 20.50 14 35838 106842 42478641
Bone density decreased 49.86 20.50 28 35824 2178 42583305
Avulsion fracture 49.20 20.50 10 35842 22 42585461
Tonsillar hypertrophy 48.99 20.50 21 35831 904 42584579
Thyroxine free increased 48.82 20.50 16 35836 321 42585162
Bradycardia 48.66 20.50 7 35845 85477 42500006
Pulmonary embolism 48.39 20.50 20 35832 119592 42465891
Attention deficit hyperactivity disorder 48.29 20.50 31 35821 3077 42582406
Leukopenia 47.90 20.50 4 35848 74742 42510741
Hyperkalaemia 47.19 20.50 6 35846 80452 42505031
Renal impairment 46.96 20.50 17 35835 110211 42475272
Cardiac arrest 46.34 20.50 17 35835 109303 42476180
Tibia fracture 46.26 20.50 25 35827 1803 42583680
Bone development abnormal 45.81 20.50 10 35842 35 42585448
Blood growth hormone increased 45.61 20.50 18 35834 626 42584857
Multiple organ dysfunction syndrome 44.81 20.50 13 35839 97022 42488461
Chills 44.56 20.50 12 35840 94054 42491429
Cardiac failure congestive 44.35 20.50 9 35843 85593 42499890
Growth failure 44.09 20.50 11 35841 77 42585406
Product administered at inappropriate site 43.49 20.50 29 35823 3069 42582414
Phaeochromocytoma 43.48 20.50 14 35838 265 42585218
Injection site extravasation 43.29 20.50 29 35823 3093 42582390
Tenosynovitis stenosans 42.79 20.50 9 35843 25 42585458
Device chemical property issue 42.57 20.50 7 35845 0 42585483
Deep vein thrombosis 42.21 20.50 7 35845 76950 42508533
Prescribed overdose 41.85 20.50 53 35799 12874 42572609
Fear of injection 41.45 20.50 24 35828 1979 42583504
Weight increased 41.19 20.50 190 35662 107793 42477690
Injection site mass 41.00 20.50 43 35809 8532 42576951
Injury associated with device 40.73 20.50 21 35831 1376 42584107
Rash 40.63 20.50 110 35742 276844 42308639
Blood testosterone free decreased 39.72 20.50 10 35842 73 42585410
Enchondromatosis 39.41 20.50 7 35845 4 42585479
Meningioma 39.25 20.50 22 35830 1705 42583778
C-reactive protein increased 39.13 20.50 4 35848 63556 42521927
Red cell distribution width decreased 39.06 20.50 13 35839 274 42585209
Hypoxia 39.06 20.50 6 35846 69780 42515703
Treatment failure 38.40 20.50 4 35848 62620 42522863
Haematocrit increased 38.39 20.50 25 35827 2542 42582941
Insulin resistance 38.31 20.50 17 35835 796 42584687
Myocardial infarction 38.27 20.50 29 35823 123980 42461503
Blood parathyroid hormone increased 37.00 20.50 22 35830 1905 42583578
Acanthosis nigricans 36.92 20.50 11 35841 159 42585324
Dehydration 36.75 20.50 39 35813 141728 42443755
Stubbornness 36.64 20.50 8 35844 28 42585455
Andropause 36.48 20.50 10 35842 105 42585378
Chronic obstructive pulmonary disease 36.31 20.50 5 35847 63109 42522374
Globulins decreased 36.11 20.50 13 35839 349 42585134
Abnormal behaviour 36.02 20.50 73 35779 26378 42559105
Knee deformity 35.78 20.50 16 35836 763 42584720
Blood glucose increased 35.31 20.50 139 35713 73560 42511923
Fall 35.25 20.50 92 35760 234428 42351055
Venous haemorrhage 35.23 20.50 8 35844 35 42585448
Blood pressure decreased 35.07 20.50 4 35848 58328 42527155
Red blood cell count increased 34.98 20.50 21 35831 1851 42583632
Non-high-density lipoprotein cholesterol increased 34.83 20.50 11 35841 195 42585288
Hypokalaemia 34.24 20.50 9 35843 71712 42513771
Pulmonary oedema 33.72 20.50 3 35849 53269 42532214
Therapy cessation 33.45 20.50 61 35791 20389 42565094
Blood triglycerides increased 33.38 20.50 53 35799 15843 42569640
Pyrexia 33.27 20.50 195 35657 393847 42191636
Strabismus 33.01 20.50 22 35830 2326 42583157
Autism spectrum disorder 32.67 20.50 24 35828 2964 42582519
Blood insulin increased 32.17 20.50 12 35840 357 42585126
Mean cell volume decreased 32.06 20.50 19 35833 1636 42583847
Blood albumin increased 31.76 20.50 15 35837 812 42584671
Oedema peripheral 31.45 20.50 41 35811 136035 42449448
Asthenia 31.19 20.50 126 35726 280667 42304816
Delirium 30.59 20.50 4 35848 52515 42532968
Mean cell haemoglobin decreased 30.57 20.50 20 35832 2050 42583433
Hypothalamo-pituitary disorder 30.53 20.50 16 35836 1084 42584399
Tendon calcification 30.49 20.50 8 35844 70 42585413
Crying 30.46 20.50 32 35820 6362 42579121
Dehydroepiandrosterone increased 30.41 20.50 5 35847 0 42585483
Adipomastia 30.41 20.50 5 35847 0 42585483
Product odour abnormal 30.21 20.50 15 35837 907 42584576
Osteosarcoma 30.15 20.50 11 35841 307 42585176
Thrombosis 30.15 20.50 10 35842 68501 42516982
Astrocytoma 30.08 20.50 10 35842 210 42585273
Product quality issue 30.08 20.50 54 35798 17828 42567655
Electrocardiogram QT prolonged 29.55 20.50 3 35849 47942 42537541
Teething 29.27 20.50 8 35844 83 42585400
Ascites 29.26 20.50 6 35846 56672 42528811
Erythema 29.24 20.50 29 35823 108764 42476719
Foetal exposure during pregnancy 29.06 20.50 3 35849 47308 42538175
Creutzfeldt-Jakob disease 28.99 20.50 7 35845 42 42585441
Pituitary tumour recurrent 28.85 20.50 8 35844 88 42585395
Migraine 28.69 20.50 65 35787 25349 42560134
Adenoidectomy 28.53 20.50 9 35843 159 42585324
Colitis 28.49 20.50 3 35849 46569 42538914
Rectal haemorrhage 28.37 20.50 4 35848 49602 42535881
Dizziness 28.21 20.50 111 35741 249143 42336340
Diabetes insipidus 28.07 20.50 24 35828 3689 42581794
Pectus carinatum 28.06 20.50 5 35847 3 42585480
Epiphyses delayed fusion 28.06 20.50 5 35847 3 42585480
Intentional dose omission 27.76 20.50 36 35816 8950 42576533
Spinal deformity 27.72 20.50 12 35840 529 42584954
Productive cough 27.60 20.50 5 35847 51562 42533921
Hepatic function abnormal 27.60 20.50 5 35847 51562 42533921
Lactic acidosis 27.47 20.50 3 35849 45258 42540225
Albumin globulin ratio increased 27.46 20.50 7 35845 54 42585429
Primary hypogonadism 27.35 20.50 8 35844 108 42585375
International normalised ratio increased 27.28 20.50 4 35848 48164 42537319
Cortisol decreased 27.16 20.50 16 35836 1362 42584121
Type 1 diabetes mellitus 27.10 20.50 28 35824 5459 42580024
Blood testosterone free increased 27.06 20.50 6 35846 23 42585460
Empty sella syndrome 27.02 20.50 7 35845 58 42585425
Plasma cell myeloma 26.83 20.50 4 35848 47574 42537909
Product contamination physical 26.70 20.50 8 35844 118 42585365
Protein-losing gastroenteropathy 26.56 20.50 11 35841 434 42585049
Acute myocardial infarction 26.46 20.50 8 35844 58157 42527326
Urinary tract infection 26.07 20.50 27 35825 99257 42486226
Low density lipoprotein increased 25.86 20.50 27 35825 5328 42580155
Cortisol increased 25.68 20.50 9 35843 223 42585260
Aural polyp 25.64 20.50 5 35847 8 42585475
Anion gap increased 25.60 20.50 18 35834 2076 42583407
Obesity 25.54 20.50 48 35804 16411 42569072
Blood pressure increased 25.35 20.50 29 35823 101899 42483584
Condition aggravated 25.32 20.50 123 35729 260631 42324852
Gynaecomastia 25.16 20.50 41 35811 12526 42572957
Mean platelet volume decreased 25.03 20.50 12 35840 672 42584811
Very low density lipoprotein increased 24.69 20.50 7 35845 84 42585399
Stomatitis 24.63 20.50 6 35846 50323 42535160
Blood creatinine increased 24.54 20.50 34 35818 109969 42475514
Dyspnoea exertional 24.50 20.50 6 35846 50142 42535341
Device-device incompatibility 24.33 20.50 4 35848 0 42585483
Mood altered 24.27 20.50 37 35815 10681 42574802
Hypoglycaemic seizure 24.23 20.50 10 35842 391 42585092
Patient-device incompatibility 23.93 20.50 6 35846 43 42585440
Breast mass 23.89 20.50 12 35840 744 42584739
White blood cell count decreased 23.76 20.50 35 35817 110361 42475122
Dysphagia 23.74 20.50 16 35836 72703 42512780
Blood alkaline phosphatase increased 23.62 20.50 72 35780 33525 42551958
Blood immunoglobulin A increased 23.51 20.50 10 35842 422 42585061
Liver disorder 23.14 20.50 3 35849 39641 42545842
Depressed level of consciousness 22.93 20.50 6 35846 47964 42537519
Anger 22.78 20.50 40 35812 12978 42572505
Arthritis 22.68 20.50 4 35848 42061 42543422
Viral infection 22.64 20.50 55 35797 22428 42563055
Growth hormone deficiency 22.64 20.50 9 35843 319 42585164
Acute respiratory failure 22.53 20.50 3 35849 38855 42546628
Loss of personal independence in daily activities 22.40 20.50 7 35845 49809 42535674
Lymphocyte count increased 22.38 20.50 22 35830 4042 42581441
Cellulitis 22.28 20.50 12 35840 61573 42523910
Loss of consciousness 22.19 20.50 27 35825 92327 42493156
Mood swings 22.18 20.50 32 35820 8794 42576689
Chest discomfort 22.14 20.50 13 35839 63603 42521880
Encephalopathy 22.13 20.50 4 35848 41329 42544154
Abdominal pain 22.06 20.50 84 35768 190387 42395096
Hepatic failure 21.96 20.50 3 35849 38097 42547386
Cardio-respiratory arrest 21.84 20.50 11 35841 58625 42526858
Hunger 21.81 20.50 16 35836 1972 42583511
Tachycardia 21.80 20.50 32 35820 101055 42484428
Apnoeic attack 21.79 20.50 10 35842 507 42584976
Haematochezia 21.71 20.50 11 35841 58425 42527058
Red cell distribution width increased 21.67 20.50 28 35824 6936 42578547
Suicide attempt 21.60 20.50 6 35846 46094 42539389
Psoriasis 21.55 20.50 7 35845 48597 42536886
Incorrect dosage administered 21.55 20.50 15 35837 1703 42583780
Haematuria 21.29 20.50 11 35841 57788 42527695
Pharyngitis streptococcal 21.27 20.50 21 35831 3879 42581604
Arnold-Chiari malformation 21.18 20.50 9 35843 379 42585104
Ependymoma malignant 21.15 20.50 5 35847 27 42585456
Mean cell haemoglobin concentration increased 21.03 20.50 10 35842 550 42584933
Blood prolactin decreased 20.93 20.50 8 35844 255 42585228
Wheezing 20.82 20.50 10 35842 54771 42530712
Heart rate decreased 20.76 20.50 3 35849 36529 42548954
Carbon dioxide decreased 20.73 20.50 16 35836 2128 42583355
Secondary hypogonadism 20.59 20.50 11 35841 775 42584708

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Drug dose omission by device 14822.05 19.81 2906 48293 11610 110526490
Device leakage 7402.49 19.81 1669 49530 14379 110523721
Device mechanical issue 6851.03 19.81 1123 50076 901 110537199
Device breakage 6435.17 19.81 1448 49751 12321 110525779
Device information output issue 6258.10 19.81 958 50241 161 110537939
Wrong technique in device usage process 4718.82 19.81 993 50206 5908 110532192
Poor quality device used 2951.74 19.81 580 50619 2283 110535817
Device issue 2860.84 19.81 927 50272 33608 110504492
Device physical property issue 2301.55 19.81 495 50704 3299 110534801
Device use error 2205.80 19.81 564 50635 8525 110529575
Device delivery system issue 1783.50 19.81 363 50836 1770 110536330
Device use issue 1781.06 19.81 401 50798 3383 110534717
Insulin-like growth factor increased 1762.69 19.81 364 50835 1932 110536168
Incorrect dose administered by device 1629.44 19.81 418 50781 6396 110531704
Device defective 1477.06 19.81 345 50854 3477 110534623
Product dose omission issue 1342.68 19.81 1142 50057 320640 110217460
Device power source issue 1326.03 19.81 263 50936 1094 110537006
Expired device used 1316.36 19.81 235 50964 457 110537643
Product prescribing error 1213.89 19.81 553 50646 50778 110487322
Device malfunction 1092.62 19.81 420 50779 25138 110512962
Insulin-like growth factor decreased 969.14 19.81 178 51021 435 110537665
Injection site pain 918.62 19.81 716 50483 177206 110360894
Device material issue 741.58 19.81 138 51061 372 110537728
Liquid product physical issue 547.87 19.81 131 51068 1469 110536631
Device failure 537.49 19.81 179 51020 7028 110531072
Incorrect dose administered 495.32 19.81 399 50800 103242 110434858
Device difficult to use 477.13 19.81 213 50986 18592 110519508
Product storage error 453.83 19.81 215 50984 21513 110516587
Craniopharyngioma 447.44 19.81 86 51113 291 110537809
Blood thyroid stimulating hormone decreased 367.47 19.81 135 51064 7104 110530996
Scoliosis 360.47 19.81 140 51059 8593 110529507
Injection site bruising 344.14 19.81 242 50957 51021 110487079
Growth retardation 317.57 19.81 94 51105 2488 110535612
Product communication issue 311.58 19.81 92 51107 2414 110535686
Epiphysiolysis 292.26 19.81 53 51146 117 110537983
Injection site haemorrhage 291.80 19.81 185 51014 32843 110505257
Needle issue 287.56 19.81 148 51051 17692 110520408
Drug administered in wrong device 268.23 19.81 48 51151 95 110538005
Adenoidal hypertrophy 250.74 19.81 49 51150 185 110537915
Dyspnoea 249.08 19.81 101 51098 1106771 109431329
Bone density increased 242.44 19.81 62 51137 933 110537167
Headache 220.19 19.81 898 50301 881479 109656621
Thyroxine free decreased 215.88 19.81 59 51140 1161 110536939
Device occlusion 210.75 19.81 114 51085 15071 110523029
Blood creatinine decreased 208.04 19.81 96 51103 9041 110529059
Sleep apnoea syndrome 206.48 19.81 162 51037 40285 110497815
Blood urea nitrogen/creatinine ratio increased 193.87 19.81 56 51143 1357 110536743
No adverse event 182.47 19.81 197 51002 73642 110464458
Toxicity to various agents 181.90 19.81 10 51189 480545 110057555
Brain neoplasm 180.86 19.81 78 51121 6259 110531841
Blood 25-hydroxycholecalciferol decreased 178.74 19.81 42 51157 434 110537666
Vitamin D decreased 175.94 19.81 94 51105 12121 110525979
Exposure via skin contact 174.96 19.81 96 51103 13051 110525049
Osteochondrosis 165.84 19.81 57 51142 2464 110535636
Poor quality product administered 165.66 19.81 67 51132 4574 110533526
Snoring 163 19.81 74 51125 6710 110531390
Diarrhoea 162.90 19.81 173 51026 1139332 109398768
Acute kidney injury 159.75 19.81 48 51151 635382 109902718
High density lipoprotein decreased 158.50 19.81 69 51130 5664 110532436
Papilloedema 156.77 19.81 74 51125 7335 110530765
Pituitary tumour benign 155.30 19.81 56 51143 2791 110535309
Wrong device used 154.62 19.81 27 51172 43 110538057
Idiopathic intracranial hypertension 151.28 19.81 60 51139 3892 110534208
Infusion related reaction 150.46 19.81 6 51193 381156 110156944
Blood glucose increased 147.69 19.81 239 50960 132257 110405843
Hypotension 144.13 19.81 33 51166 523816 110014284
Blood triglycerides increased 142.32 19.81 105 51094 23821 110514279
Glycosylated haemoglobin increased 141.27 19.81 104 51095 23515 110514585
Confusional state 140.51 19.81 24 51175 468656 110069444
Device dispensing error 133.85 19.81 29 51170 200 110537900
Non-high-density lipoprotein cholesterol increased 132.43 19.81 32 51167 376 110537724
Drug ineffective 130.75 19.81 323 50876 1520217 109017883
Pneumonia 129.77 19.81 129 51070 876585 109661515
Glioneuronal tumour 126.89 19.81 19 51180 0 110538100
Circumstance or information capable of leading to device use error 126.71 19.81 28 51171 214 110537886
Low density lipoprotein increased 125.92 19.81 72 51127 10594 110527506
Wrong technique in product usage process 124.94 19.81 177 51022 87171 110450929
Nausea 121.23 19.81 244 50955 1235446 109302654
Pruritus 121.11 19.81 59 51140 581501 109956599
General physical health deterioration 120.59 19.81 25 51174 425270 110112830
Neoplasm recurrence 119.20 19.81 55 51144 5177 110532923
Blood testosterone decreased 115.19 19.81 45 51154 2803 110535297
Septo-optic dysplasia 113.53 19.81 17 51182 0 110538100
Intracranial pressure increased 113.46 19.81 67 51132 10468 110527632
Anaemia 111.65 19.81 57 51142 547029 109991071
Device electrical finding 111.37 19.81 27 51172 322 110537778
Blood thyroid stimulating hormone increased 111.36 19.81 70 51129 12231 110525869
Blood testosterone increased 109.23 19.81 36 51163 1366 110536734
Circumstance or information capable of leading to medication error 106.84 19.81 51 51148 5182 110532918
Rash 105.93 19.81 135 51064 820829 109717271
Epiphyses premature fusion 104.61 19.81 22 51177 129 110537971
Acromegaly 104.47 19.81 22 51177 130 110537970
Thrombocytopenia 104.23 19.81 18 51181 348867 110189233
Neutropenia 102.19 19.81 24 51175 374596 110163504
Tonsillar hypertrophy 101.53 19.81 37 51162 1901 110536199
Stomatitis 101.03 19.81 6 51193 270236 110267864
Systemic lupus erythematosus 100.35 19.81 4 51195 254334 110283766
Product dispensing error 100.07 19.81 73 51126 16272 110521828
Rheumatoid arthritis 99.99 19.81 11 51188 299602 110238498
Hepatic enzyme increased 99.34 19.81 15 51184 320877 110217223
Growing pains 97.38 19.81 17 51182 27 110538073
Injection site discharge 96.00 19.81 33 51166 1427 110536673
Contraindicated product administered 94.38 19.81 5 51194 248262 110289838
Weight gain poor 93.39 19.81 32 51167 1370 110536730
Accidental exposure to product 92.56 19.81 115 51084 49893 110488207
Increased appetite 91.94 19.81 67 51132 14910 110523190
Thyroxine increased 91.92 19.81 29 51170 955 110537145
Hepatoblastoma 91.83 19.81 17 51182 44 110538056
Drug intolerance 89.63 19.81 38 51161 406474 110131626
Clear cell renal cell carcinoma 88.88 19.81 37 51162 2719 110535381
Completed suicide 88.75 19.81 6 51193 242375 110295725
Device operational issue 87.92 19.81 29 51170 1103 110536997
Blister 85.13 19.81 5 51194 227371 110310729
Thyroxine free increased 84.53 19.81 30 51169 1427 110536673
Drug hypersensitivity 84.44 19.81 53 51146 454037 110084063
Adrenocortical insufficiency acute 83.78 19.81 41 51158 4399 110533701
Product reconstitution quality issue 80.45 19.81 21 51178 344 110537756
Tonsillar disorder 80.14 19.81 29 51170 1460 110536640
Maternal exposure during pregnancy 78.68 19.81 12 51187 254871 110283229
Psoriatic arthropathy 77.93 19.81 3 51196 196758 110341342
Meningioma 77.12 19.81 42 51157 5623 110532477
Joint swelling 76.57 19.81 56 51143 442789 110095311
Blood follicle stimulating hormone decreased 76.08 19.81 18 51181 192 110537908
Product preparation issue 75.37 19.81 33 51166 2746 110535354
Blood luteinising hormone decreased 74.26 19.81 17 51182 155 110537945
Mobility decreased 73.69 19.81 11 51188 237411 110300689
Drug interaction 73.39 19.81 74 51125 500109 110037991
Pituitary tumour recurrent 72.76 19.81 17 51182 171 110537929
Abdominal discomfort 71.80 19.81 47 51152 393811 110144289
Arthropathy 71.63 19.81 22 51177 287500 110250600
Pituitary tumour 69.67 19.81 25 51174 1228 110536872
Thyroxine decreased 69.18 19.81 23 51176 897 110537203
Pancytopenia 69.16 19.81 8 51191 209605 110328495
Focal segmental glomerulosclerosis 68.55 19.81 35 51164 4110 110533990
Atrial fibrillation 68.23 19.81 12 51187 229630 110308470
Malignant neoplasm progression 68.00 19.81 3 51196 174564 110363536
Sepsis 66.87 19.81 34 51165 327312 110210788
Device chemical property issue 66.78 19.81 10 51189 0 110538100
Pain 65.60 19.81 225 50974 954730 109583370
Product administered at inappropriate site 65.26 19.81 37 51162 5356 110532744
Cortisol decreased 65.19 19.81 30 51169 2806 110535294
Wheezing 64.53 19.81 19 51180 255211 110282889
Precocious puberty 64.53 19.81 18 51181 383 110537717
Injection site discomfort 64.27 19.81 40 51159 6867 110531233
Swelling 63.83 19.81 42 51157 350999 110187101
C-reactive protein increased 63.42 19.81 12 51187 217907 110320193
Helicobacter infection 62.41 19.81 6 51193 181871 110356229
Mood altered 61.69 19.81 62 51137 21313 110516787
Dry mouth 60.38 19.81 10 51189 199938 110338162
Lymphoproliferative disorder 60.18 19.81 39 51160 7179 110530921
Blood insulin increased 59.77 19.81 17 51182 389 110537711
Device deployment issue 59.20 19.81 32 51167 4221 110533879
Exposure during pregnancy 58.86 19.81 5 51194 167419 110370681
Adenoidectomy 58.70 19.81 14 51185 155 110537945
Therapeutic product effect decreased 58.54 19.81 20 51179 244296 110293804
Blood growth hormone increased 58.22 19.81 21 51178 1047 110537053
Albumin globulin ratio increased 58.19 19.81 13 51186 105 110537995
Therapeutic response unexpected 57.80 19.81 63 51136 23780 110514320
Hepatic necrosis 57.78 19.81 43 51156 9879 110528221
Blood testosterone free decreased 57.51 19.81 11 51188 36 110538064
Musculoskeletal stiffness 57.24 19.81 29 51170 279793 110258307
Globulins decreased 56.93 19.81 19 51180 750 110537350
Impaired healing 56.88 19.81 11 51188 196706 110341394
Cortisol increased 56.39 19.81 18 51181 616 110537484
Blood albumin increased 55.86 19.81 24 51175 1907 110536193
Therapy cessation 55.60 19.81 85 51114 44772 110493328
Osteoarthritis 55.44 19.81 9 51190 182614 110355486
Cerebral salt-wasting syndrome 55.42 19.81 15 51184 284 110537816
Fibromyalgia 55.20 19.81 7 51192 170902 110367198
Lower respiratory tract infection 54.72 19.81 22 51177 243084 110295016
Respiratory failure 54.49 19.81 16 51183 215316 110322784
Gastrointestinal disorder 54.29 19.81 22 51177 241930 110296170
Blood growth hormone decreased 53.95 19.81 11 51188 54 110538046
Product odour abnormal 53.58 19.81 22 51177 1561 110536539
Blood urea decreased 53.49 19.81 28 51171 3462 110534638
Blood alkaline phosphatase decreased 53.43 19.81 25 51174 2428 110535672
Platelet count decreased 53.28 19.81 20 51179 230423 110307677
Injection site mass 52.76 19.81 61 51138 24552 110513548
Astrocytoma 52.71 19.81 14 51185 246 110537854
Autism spectrum disorder 52.40 19.81 23 51176 1925 110536175
Energy increased 52.14 19.81 28 51171 3646 110534454
Hypersensitivity 51.40 19.81 67 51132 403931 110134169
Blood corticotrophin decreased 51.21 19.81 18 51181 832 110537268
Bradycardia 51.13 19.81 6 51193 155511 110382589
Blood alkaline phosphatase increased 51.10 19.81 106 51093 70829 110467271
Hypokalaemia 51.10 19.81 11 51188 182437 110355663
Injury 51.07 19.81 10 51189 177255 110360845
Blood follicle stimulating hormone increased 50.70 19.81 15 51184 396 110537704
Lymphocyte count increased 50.63 19.81 35 51164 7168 110530932
Dyspepsia 50.54 19.81 13 51186 190952 110347148
Delirium 50.44 19.81 3 51196 135022 110403078
Anion gap increased 50.41 19.81 29 51170 4315 110533785
Infection 50.39 19.81 56 51143 362144 110175956
Blood prolactin decreased 50.36 19.81 14 51185 294 110537806
Osteosarcoma 50.07 19.81 15 51184 414 110537686
Interstitial lung disease 49.42 19.81 4 51195 139330 110398770
Glucose tolerance impaired 49.32 19.81 39 51160 9798 110528302
Fall 48.63 19.81 132 51067 603350 109934750
Renal failure 48.60 19.81 22 51177 226552 110311548
Liver disorder 48 19.81 5 51194 142238 110395862
Off label use 47.97 19.81 966 50233 1499219 109038881
Hyperkalaemia 47.88 19.81 4 51195 135792 110402308
Neuropathy peripheral 47.84 19.81 12 51187 179265 110358835
Type 1 diabetes mellitus 47.81 19.81 37 51162 9010 110529090
Inflammation 47.73 19.81 15 51184 193223 110344877
Arnold-Chiari malformation 47.55 19.81 13 51186 256 110537844
Pleural effusion 47.22 19.81 12 51187 177697 110360403
Arthritis 47.14 19.81 10 51189 167576 110370524
Knee deformity 47.11 19.81 20 51179 1543 110536557
Seizure 47 19.81 215 50984 220970 110317130
Haematocrit increased 46.85 19.81 29 51170 4930 110533170
Blood sodium increased 46.44 19.81 30 51169 5493 110532607
Medulloblastoma recurrent 46.35 19.81 12 51187 190 110537910
Lung disorder 46.25 19.81 13 51186 180034 110358066
Product contamination 46.19 19.81 21 51178 1910 110536190
Medulloblastoma 46.10 19.81 11 51188 122 110537978
Pulmonary embolism 45.73 19.81 21 51178 214453 110323647
Carbon dioxide decreased 45.58 19.81 28 51171 4696 110533404
Cardiac failure 45.57 19.81 15 51184 187611 110350489
Septic shock 45.14 19.81 9 51190 157519 110380581
Strabismus 45.04 19.81 25 51174 3474 110534626
Red blood cell count increased 44.55 19.81 28 51171 4890 110533210
Deep vein thrombosis 44.52 19.81 6 51193 139881 110398219
Hypothalamo-pituitary disorder 44.10 19.81 23 51176 2823 110535277
Very low density lipoprotein increased 44.09 19.81 13 51186 339 110537761
Osteochondroma 44.01 19.81 8 51191 18 110538082
Leukopenia 43.70 19.81 8 51191 148783 110389317
Acne 43.65 19.81 65 51134 33455 110504645
Blood parathyroid hormone increased 43.10 19.81 26 51173 4222 110533878
Erythema 42.84 19.81 43 51156 291404 110246696
Protein-losing gastroenteropathy 42.68 19.81 16 51183 890 110537210
Blood glucose decreased 42.50 19.81 60 51139 29428 110508672
Gastrointestinal haemorrhage 42.42 19.81 12 51187 165506 110372594
Andropause 42.41 19.81 10 51189 105 110537995
Chest pain 42.37 19.81 68 51131 376307 110161793
Intentional dose omission 41.76 19.81 49 51150 20031 110518069
Bone density decreased 41.72 19.81 44 51155 15998 110522102
Intercepted product prescribing error 41.65 19.81 13 51186 413 110537687
Mean cell haemoglobin decreased 41.57 19.81 31 51168 7143 110530957
Bone development abnormal 41.55 19.81 9 51190 62 110538038
Abnormal behaviour 41.54 19.81 69 51130 38970 110499130
Hypertension 41.51 19.81 111 51088 509973 110028127
Skin odour abnormal 41.40 19.81 21 51178 2433 110535667
Enuresis 41.38 19.81 25 51174 4071 110534029
Cough 41.03 19.81 96 51103 461545 110076555
Alopecia 40.97 19.81 66 51133 364687 110173413
Blood testosterone free increased 40.97 19.81 7 51192 9 110538091
Germ cell cancer 40.96 19.81 11 51188 202 110537898
Cardiac arrest 40.82 19.81 20 51179 196733 110341367
Anger 40.56 19.81 47 51152 18960 110519140
Injection site extravasation 39.93 19.81 35 51164 10134 110527966
Urinary tract infection 39.58 19.81 56 51143 326226 110211874
Pyrexia 39.43 19.81 249 50950 898016 109640084
Renal impairment 39.33 19.81 19 51180 188426 110349674
Joint range of motion decreased 39.31 19.81 5 51194 121827 110416273
Attention deficit hyperactivity disorder 39.26 19.81 25 51174 4466 110533634
Sinusitis 38.97 19.81 48 51151 296640 110241460
Insulin resistance 38.79 19.81 18 51181 1716 110536384
Productive cough 38.61 19.81 4 51195 114301 110423799
Cardiac failure congestive 38.60 19.81 11 51188 150989 110387111
Blood prolactin increased 38.50 19.81 25 51174 4617 110533483
Rectal haemorrhage 38.47 19.81 5 51194 119828 110418272
Tri-iodothyronine decreased 38.42 19.81 12 51187 382 110537718
Irritable bowel syndrome 38.38 19.81 14 51185 164201 110373899
Red cell distribution width increased 38.36 19.81 44 51155 17558 110520542
Cryptorchism 38.03 19.81 8 51191 47 110538053
Blood chloride increased 37.97 19.81 28 51171 6344 110531756
Dehydroepiandrosterone increased 37.64 19.81 6 51193 3 110538097
Phaeochromocytoma 36.48 19.81 14 51185 831 110537269
Chronic obstructive pulmonary disease 36.41 19.81 4 51195 109154 110428946
Hormone level abnormal 36.21 19.81 19 51180 2361 110535739
Growth hormone deficiency 36.17 19.81 12 51187 465 110537635
Limb asymmetry 36.10 19.81 13 51186 645 110537455
Disease progression 35.87 19.81 36 51163 243998 110294102
Chills 35.72 19.81 22 51177 190558 110347542
Fear of injection 35.65 19.81 31 51168 8880 110529220
Hypopituitarism 34.84 19.81 23 51176 4367 110533733
Condition aggravated 34.69 19.81 199 51000 734637 109803463
Empty sella syndrome 34.62 19.81 9 51190 145 110537955
Musculoskeletal pain 34.48 19.81 21 51178 183002 110355098
Psoriasis 34.33 19.81 11 51188 139982 110398118
Hypoaesthesia 34.22 19.81 58 51141 314165 110223935
Blood pressure decreased 34.20 19.81 6 51193 115085 110423015
Aggression 34.20 19.81 81 51118 59129 110478971
Tri-iodothyronine free increased 34.09 19.81 10 51189 256 110537844
Reaction to preservatives 34.02 19.81 10 51189 258 110537842
Mean platelet volume increased 33.87 19.81 16 51183 1588 110536512
Multiple organ dysfunction syndrome 33.69 19.81 14 51185 151696 110386404
Neutrophilic panniculitis 33.59 19.81 8 51191 88 110538012
Discomfort 33.51 19.81 30 51169 214677 110323423
Device-device incompatibility 33.39 19.81 5 51194 0 110538100
Noonan syndrome 33.39 19.81 5 51194 0 110538100
Acral overgrowth 33.39 19.81 5 51194 0 110538100
Coma 33.22 19.81 7 51192 117862 110420238
Loss of personal independence in daily activities 33.06 19.81 14 51185 150006 110388094
Dizziness 32.99 19.81 189 51010 698004 109840096
Haemoglobin increased 32.98 19.81 30 51169 9117 110528983
Infantile haemangioma 32.85 19.81 6 51193 14 110538086
Diabetes insipidus 32.84 19.81 26 51173 6544 110531556
Oedema peripheral 32.81 19.81 64 51135 328596 110209504
Intentional product misuse 32.66 19.81 135 51064 132769 110405331
Perthes disease 32.28 19.81 6 51193 16 110538084
Hypoxia 32.07 19.81 10 51189 129505 110408595
Night sweats 32.03 19.81 11 51188 133972 110404128
Alveolar rhabdomyosarcoma 32.02 19.81 6 51193 17 110538083
Focal nodular hyperplasia 31.96 19.81 13 51186 900 110537200
Dyspnoea exertional 31.87 19.81 5 51194 104055 110434045
Avulsion fracture 31.76 19.81 10 51189 327 110537773
Product deposit 31.58 19.81 12 51187 693 110537407
Dysphagia 31.28 19.81 16 51183 153584 110384516
Astrocytoma, low grade 31.24 19.81 8 51191 121 110537979
Therapy non-responder 31.13 19.81 17 51182 157290 110380810
Hyponatraemic seizure 31.03 19.81 12 51187 727 110537373
Blood calcium increased 31.02 19.81 40 51159 18000 110520100
Muscular weakness 30.77 19.81 42 51157 248426 110289674
Tibia fracture 30.66 19.81 25 51174 6560 110531540
Primary hypogonadism 30.44 19.81 9 51190 237 110537863
Asthenia 30.19 19.81 191 51008 688808 109849292
Intentional overdose 29.79 19.81 12 51187 132489 110405611
Teething 29.73 19.81 8 51191 148 110537952
Adverse event 29.58 19.81 7 51192 108802 110429298
Mean cell haemoglobin concentration decreased 29.51 19.81 23 51176 5659 110532441
Lactic acidosis 29.49 19.81 4 51195 92807 110445293
Growth failure 29.45 19.81 9 51190 266 110537834
Mean cell volume decreased 29.43 19.81 23 51176 5679 110532421
Tachycardia 29.41 19.81 37 51162 226608 110311492
Hyperphagia 29.24 19.81 19 51180 3512 110534588
Intentional device misuse 29.08 19.81 12 51187 862 110537238
Colitis 28.99 19.81 6 51193 102317 110435783
Product solubility abnormal 28.94 19.81 13 51186 1149 110536951
Temperature intolerance 28.94 19.81 34 51165 13916 110524184
Pre-existing condition improved 28.76 19.81 24 51175 6502 110531598
Medication error 28.21 19.81 7 51192 105359 110432741
Ill-defined disorder 28.17 19.81 19 51180 156834 110381266
Abdominal pain 28.08 19.81 132 51067 512857 110025243
Viral infection 27.82 19.81 70 51129 53069 110485031
Tendon calcification 27.77 19.81 8 51191 192 110537908
Multiple use of single-use product 27.59 19.81 13 51186 1283 110536817
Herpes zoster 27.50 19.81 8 51191 108371 110429729
Chest discomfort 27.48 19.81 24 51175 173824 110364276
Manufacturing product shipping issue 27.39 19.81 7 51192 105 110537995
Delayed puberty 27.30 19.81 8 51191 204 110537896
Ascites 27.23 19.81 5 51194 92803 110445297
Neurofibromatosis 27.08 19.81 8 51191 210 110537890
International normalised ratio increased 26.96 19.81 4 51195 86768 110451332
Crying 26.86 19.81 45 51154 25583 110512517
Hair growth abnormal 26.79 19.81 18 51181 3519 110534581
Tri-iodothyronine increased 26.76 19.81 9 51190 364 110537736
Puberty 26.71 19.81 4 51195 0 110538100
Gait inability 26.60 19.81 15 51184 136361 110401739
Grip strength decreased 26.58 19.81 3 51196 80171 110457929
Patient-device incompatibility 26.56 19.81 8 51191 225 110537875
Mean cell haemoglobin concentration increased 26.44 19.81 12 51187 1087 110537013
Gynaecomastia 26.42 19.81 27 51172 9463 110528637
Hypercholesterolaemia 26.42 19.81 5 51194 90832 110447268
Pulmonary oedema 26.35 19.81 7 51192 100652 110437448
Nasopharyngitis 26.25 19.81 94 51105 394267 110143833
Secondary hypogonadism 25.87 19.81 11 51188 852 110537248
Dysarthria 25.85 19.81 4 51195 84117 110453983
Vitamin D deficiency 25.63 19.81 37 51162 18515 110519585
Suicide attempt 25.57 19.81 8 51191 103386 110434714
Injury associated with device 25.51 19.81 19 51180 4370 110533730
Liver function test increased 25.49 19.81 5 51194 88543 110449557
Blood urea nitrogen/creatinine ratio decreased 25.43 19.81 8 51191 261 110537839
Total cholesterol/HDL ratio decreased 25.36 19.81 6 51193 64 110538036
Product physical issue 25.32 19.81 20 51179 5016 110533084
Monocyte count increased 25.28 19.81 31 51168 13262 110524838
Carbon dioxide increased 25.28 19.81 16 51183 2828 110535272
Blood immunoglobulin A increased 25.24 19.81 13 51186 1555 110536545
Mood swings 25.18 19.81 41 51158 22771 110515329
Human epidermal growth factor receptor decreased 25.16 19.81 5 51194 21 110538079
Syringomyelia 24.94 19.81 8 51191 278 110537822
Pulmonary valve stenosis 24.79 19.81 7 51192 156 110537944
Device connection issue 24.75 19.81 12 51187 1262 110536838
Abdominal pain upper 24.73 19.81 81 51118 349030 110189070
Hypoglycaemic seizure 24.61 19.81 11 51188 961 110537139
Pectus carinatum 24.48 19.81 4 51195 3 110538097
Product use issue 24.45 19.81 69 51130 311626 110226474
Cellulitis 24.38 19.81 14 51185 126002 110412098
Dehydroepiandrosterone decreased 24.28 19.81 5 51194 26 110538074
Product contamination physical 24.23 19.81 8 51191 305 110537795
Thirst 23.94 19.81 39 51160 21668 110516432
Talipes 23.76 19.81 7 51192 182 110537918
Hypertrophic cardiomyopathy 23.73 19.81 16 51183 3147 110534953
Product packaging quantity issue 23.56 19.81 13 51186 1786 110536314
Limb deformity 23.54 19.81 17 51182 3729 110534371
Blood pressure increased 23.52 19.81 53 51146 258320 110279780
Breast discomfort 23.50 19.81 9 51190 531 110537569
Bone sarcoma 23.48 19.81 6 51193 90 110538010
Red cell distribution width decreased 23.47 19.81 14 51185 2227 110535873
Nail bed disorder 23.34 19.81 8 51191 343 110537757
Hypoglycaemia 23.28 19.81 111 51088 115993 110422107
Cerebral amyloid angiopathy 23.26 19.81 9 51190 546 110537554
Blood pressure systolic increased 23.24 19.81 5 51194 82986 110455114
Apnoeic attack 23.19 19.81 10 51189 802 110537298
Heart rate decreased 23.14 19.81 5 51194 82751 110455349
Haemoptysis 22.85 19.81 3 51196 71351 110466749
Venous haemorrhage 22.78 19.81 8 51191 369 110537731
Epiphyses delayed fusion 22.67 19.81 4 51195 7 110538093
Manufacturing product storage issue 22.67 19.81 4 51195 7 110538093
Hepatic encephalopathy 22.46 19.81 44 51155 28212 110509888
Encephalopathy 22.46 19.81 5 51194 81050 110457050
Otitis media 22.15 19.81 22 51177 7454 110530646
Blood growth hormone abnormal 22.10 19.81 5 51194 43 110538057
Sex hormone binding globulin increased 22.00 19.81 4 51195 9 110538091
Blood chloride decreased 21.94 19.81 24 51175 9091 110529009
Total cholesterol/HDL ratio increased 21.93 19.81 8 51191 412 110537688
Paraesthesia 21.84 19.81 61 51138 276460 110261640
Liver function test abnormal 21.84 19.81 3 51196 68947 110469153
Product dispensing issue 21.83 19.81 9 51190 645 110537455
Decreased appetite 21.81 19.81 130 51069 475716 110062384
Hepatic failure 21.75 19.81 3 51196 68736 110469364
Product preparation error 21.72 19.81 26 51173 10853 110527247
Gastrooesophageal reflux disease 21.70 19.81 31 51168 179945 110358155
Stubbornness 21.55 19.81 8 51191 433 110537667
Asthma 21.46 19.81 53 51146 250238 110287862
Blood 25-hydroxycholecalciferol increased 21.17 19.81 4 51195 12 110538088
Product availability issue 21.16 19.81 22 51177 7868 110530232
Disease recurrence 21.04 19.81 69 51130 60715 110477385
Oxygen saturation decreased 21.02 19.81 25 51174 156957 110381143
Colitis ulcerative 20.98 19.81 5 51194 77358 110460742
Aortic valve disease 20.98 19.81 13 51186 2214 110535886
Developmental hip dysplasia 20.98 19.81 7 51192 276 110537824
Depressed level of consciousness 20.98 19.81 13 51186 112265 110425835
Type 2 diabetes mellitus 20.90 19.81 31 51168 177201 110360899
Oedema 20.85 19.81 41 51158 209935 110328165
Cardio-respiratory arrest 20.84 19.81 14 51185 115822 110422278
Mean platelet volume decreased 20.79 19.81 15 51184 3285 110534815
Incorrect dosage administered 20.65 19.81 16 51183 3902 110534198
Hepatitis 20.50 19.81 8 51191 90046 110448054
Taste disorder 20.34 19.81 3 51196 65384 110472716
Hypocalcaemia 20.34 19.81 3 51196 65363 110472737
Blood corticotrophin increased 20.33 19.81 7 51192 304 110537796
Arthralgia 20.28 19.81 488 50711 779144 109758956
White blood cell count decreased 20.12 19.81 48 51151 229342 110308758
Optic nerve hypoplasia 20.09 19.81 4 51195 17 110538083
Postprandial hypoglycaemia 20.08 19.81 6 51193 164 110537936
Rathke's cleft cyst 20.04 19.81 3 51196 0 110538100
Adipomastia 20.04 19.81 3 51196 0 110538100
Bilateral breast buds 20.04 19.81 3 51196 0 110538100
Silver-Russell syndrome 20.04 19.81 3 51196 0 110538100
Acquired syringomyelia 20.04 19.81 3 51196 0 110538100
Habit cough 20.04 19.81 3 51196 0 110538100
Pituitary haemorrhage 20.01 19.81 7 51192 319 110537781
Electric shock sensation 19.98 19.81 12 51187 1932 110536168
Performance enhancing product use 19.98 19.81 6 51193 167 110537933
Sedation 19.92 19.81 4 51195 69679 110468421
Optic glioma 19.82 19.81 5 51194 71 110538029

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
ATC H01AC01 SYSTEMIC HORMONAL PREPARATIONS, EXCL. SEX HORMONES AND INSULINS
PITUITARY AND HYPOTHALAMIC HORMONES AND ANALOGUES
ANTERIOR PITUITARY LOBE HORMONES AND ANALOGUES
Somatropin and somatropin agonists
FDA CS M0028842 Human Growth Hormone
FDA EPC N0000175606 Recombinant Human Growth Hormone
CHEBI has role CHEBI:35526 hypoglycemic agent
CHEBI has role CHEBI:35554 cardiovascular drug
CHEBI has role CHEBI:62868 hepatoprotective agent
CHEBI has role CHEBI:63726 neuroprotective agent
CHEBI has role CHEBI:64946 anti-HIV agent
CHEBI has role CHEBI:67079 anti-inflammatory agent
CHEBI has role CHEBI:74518 anti-obesity agent
CHEBI has role CHEBI:176497 geroprotector
CHEBI has role CHEBI:231911 renoprotective agent

Related Drugs by ATC class:

H01AC Somatropin and somatropin agonists 8 drugs
lonapegsomatropinmecaserminmecasermin rinfabatesermorelinsomapacitansomatremsomatrogontesamorelin

Drug Use | Suggest Off label Use Form| |View source of the data|

DiseaseRelationSNOMED_IDDOID
Turner syndrome indication 38804009 DOID:3491
Prader-Willi syndrome indication 89392001 DOID:11983
Short stature associated with Noonan syndrome indication 205824006 DOID:3490
Pituitary dwarfism indication 367460001 DOID:0060870
Severe growth hormone deficiency in adulthood indication 421684006
Growth retardation indication 444896005
Short stature in SHOX deficiency indication 763868006




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

None

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])		Mechanism
action		Bioact sourceMoA source
Growth hormone receptor Membrane receptor AGONIST DRUG LABEL DRUG LABEL

External reference:

IDSource
NQX9KB6PCL UNII
D02691 KEGG_DRUG
4020552 VUID
N0000148258 NUI
4020552 VANDF
C3714500 UMLSCUI
CHEBI:749556 CHEBI
CHEMBL1201621 ChEMBL_ID
DB00052 DRUGBANK_ID
239 INN_ID
61148 RXNORM
5501 MMSL
82320 MMSL
d00577 MMSL
002104 NDDF
002106 NDDF
129495007 SNOMEDCT_US
395883003 SNOMEDCT_US
713492005 SNOMEDCT_US
D019382 MESH_DESCRIPTOR_UI
16132356 PUBCHEM_CID

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
Norditropin HUMAN PRESCRIPTION DRUG LABEL 1 0169-7703 INJECTION, SOLUTION 30 mg SUBCUTANEOUS BLA 27 sections
Norditropin HUMAN PRESCRIPTION DRUG LABEL 1 0169-7704 INJECTION, SOLUTION 5 mg SUBCUTANEOUS BLA 27 sections
Norditropin HUMAN PRESCRIPTION DRUG LABEL 1 0169-7705 INJECTION, SOLUTION 10 mg SUBCUTANEOUS BLA 27 sections
Norditropin HUMAN PRESCRIPTION DRUG LABEL 1 0169-7708 INJECTION, SOLUTION 15 mg SUBCUTANEOUS BLA 27 sections
Omnitrope HUMAN PRESCRIPTION DRUG LABEL 1 0781-3001 INJECTION, SOLUTION 5 mg SUBCUTANEOUS BLA 26 sections
Omnitrope HUMAN PRESCRIPTION DRUG LABEL 1 0781-3004 INJECTION, SOLUTION 10 mg SUBCUTANEOUS BLA 26 sections
Norditropin HUMAN PRESCRIPTION DRUG LABEL 1 54868-6146 INJECTION, SOLUTION 5 mg SUBCUTANEOUS NDA 25 sections