Stem definition | Drug id | CAS RN |
---|---|---|
insulin-like growth factors | 5009 | 68562-41-4 |
Molecule | Description |
---|---|
Synonyms:
|
Recombinant form of endogenous Insulin-like Growth Factor 1 exhibiting mitogenic activity. Clinical Use: Diabetes Mellitus and Amyotrophic Lateral Sclerosis.
|
Dose | Unit | Route |
---|---|---|
2 | mg | P |
None
Date | Agency | Company | Orphan |
---|---|---|---|
March 8, 2007 | EMA | ||
Aug. 30, 2005 | FDA | IPSEN INC |
MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
---|---|---|---|---|---|---|
Hypoglycaemia | 59.65 | 40.75 | 19 | 281 | 53562 | 50551262 |
Tonsillar hypertrophy | 43.61 | 40.75 | 7 | 293 | 859 | 50603965 |
MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
---|---|---|---|---|---|---|
Tonsillar hypertrophy | 119.29 | 48.00 | 19 | 645 | 574 | 29573289 |
Product dose omission issue | 59.80 | 48.00 | 33 | 631 | 96350 | 29477513 |
Adenoidal hypertrophy | 55.32 | 48.00 | 8 | 656 | 123 | 29573740 |
Hypoglycaemia | 51.79 | 48.00 | 24 | 640 | 48322 | 29525541 |
MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
---|---|---|---|---|---|---|
Tonsillar hypertrophy | 135.27 | 40.40 | 22 | 847 | 1279 | 64496584 |
Hypoglycaemia | 98.46 | 40.40 | 39 | 830 | 89853 | 64408010 |
Product dose omission issue | 61.56 | 40.40 | 36 | 833 | 194711 | 64303152 |
Adenoidal hypertrophy | 58.52 | 40.40 | 8 | 861 | 138 | 64497725 |
Snoring | 40.78 | 40.40 | 10 | 859 | 4672 | 64493191 |
None
Source | Code | Description |
---|---|---|
ATC | H01AC03 | SYSTEMIC HORMONAL PREPARATIONS, EXCL. SEX HORMONES AND INSULINS PITUITARY AND HYPOTHALAMIC HORMONES AND ANALOGUES ANTERIOR PITUITARY LOBE HORMONES AND ANALOGUES Somatropin and somatropin agonists |
MeSH PA | D006133 | Growth Substances |
Disease | Relation | SNOMED_ID | DOID |
---|---|---|---|
Laron-type isolated somatotropin defect | indication | 38196001 | DOID:9521 |
None
None
None
None
None
Target | Class | Pharos | UniProt | Action | Type | Activity value (-log[M]) | Mechanism action | Bioact source | MoA source |
---|---|---|---|---|---|---|---|---|---|
Insulin-like growth factor 1 receptor | Kinase | AGONIST | IC50 | 8.31 | SCIENTIFIC LITERATURE | DRUG LABEL | |||
Insulin receptor | Kinase | IC50 | 5.85 | SCIENTIFIC LITERATURE |
ID | Source |
---|---|
D03297 | KEGG_DRUG |
4024932 | VUID |
N0000023113 | NUI |
4024932 | VANDF |
CHEBI:80343 | CHEBI |
CHEMBL1201716 | ChEMBL_ID |
C000604197 | MESH_SUPPLEMENTAL_RECORD_UI |
4971 | IUPHAR_LIGAND_ID |
6372 | INN_ID |
DB01277 | DRUGBANK_ID |
7GR9I2683O | UNII |
274403 | RXNORM |
20506 | MMSL |
71163 | MMSL |
d05636 | MMSL |
418157000 | SNOMEDCT_US |
418845006 | SNOMEDCT_US |
5699003 | SNOMEDCT_US |
C0904505 | UMLSCUI |
011016 | NDDF |
Product | Category | Ingredients | NDC | Form | Quantity | Route | Marketing | Label |
---|---|---|---|---|---|---|---|---|
Increlex | HUMAN PRESCRIPTION DRUG LABEL | 1 | 15054-1040 | INJECTION, SOLUTION | 40 mg | SUBCUTANEOUS | BLA | 30 sections |
Cosmeceutical Mask Pack | HUMAN OTC DRUG LABEL | 6 | 60709-102 | PATCH | 0.04 mg | TOPICAL | unapproved drug other | 9 sections |
Dermaheal Cosmeceutical Mask Pack Plus | HUMAN OTC DRUG LABEL | 6 | 60709-105 | PATCH | 0.04 mg | TOPICAL | unapproved drug other | 9 sections |