mecasermin 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | PK/Tox | Related Drugs | BioActivity |

Stem definitionDrug idCAS RN
insulin-like growth factors 5009 68562-41-4

Description:

MoleculeDescription

Synonyms:

  • mecasermin recombinant
  • mecasermin
  • increlex
  • somatomedin C
  • Somatomedin-C
  • IGF1
  • insulin-like growth factor 1
Recombinant form of endogenous Insulin-like Growth Factor 1 exhibiting mitogenic activity. Clinical Use: Diabetes Mellitus and Amyotrophic Lateral Sclerosis.
  • Molecular weight: 7648.71
  • Formula: C331H512N94O101S7
  • CLOGP:
  • LIPINSKI: None
  • HAC: None
  • HDO: None
  • TPSA: 3126.93
  • ALOGS:
  • ROTB: None

Drug dosage:

DoseUnitRoute
2 mg P

ADMET properties:

None

Predicted pharmacokinetic/toxicological properties (PK-AZ):

None

Approvals:

DateAgencyCompanyOrphan
Aug. 30, 2005 FDA IPSEN INC
March 8, 2007 EMA

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Hypoglycaemia 73.07 40.51 21 302 69827 90558297
Tonsillar hypertrophy 45.05 40.51 7 316 1165 90626959

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Tonsillar hypertrophy 151.35 48.00 24 731 901 42619679
Product dose omission issue 65.58 48.00 38 717 154327 42466253
Hypoglycaemia 65.21 48.00 28 727 59826 42560754
Adenoidal hypertrophy 54.23 48.00 8 747 182 42620398

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Tonsillar hypertrophy 171.70 40.91 27 968 1911 110586393
Hypoglycaemia 126.37 40.91 45 950 116059 110472245
Product dose omission issue 71.31 40.91 41 954 321741 110266563
Adenoidal hypertrophy 57.98 40.91 8 987 226 110588078
Papilloedema 50.46 40.91 12 983 7397 110580907
Snoring 46.26 40.91 11 984 6773 110581531

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
ATC H01AC03 SYSTEMIC HORMONAL PREPARATIONS, EXCL. SEX HORMONES AND INSULINS
PITUITARY AND HYPOTHALAMIC HORMONES AND ANALOGUES
ANTERIOR PITUITARY LOBE HORMONES AND ANALOGUES
Somatropin and somatropin agonists
MeSH PA D006133 Growth Substances
CHEBI has role CHEBI:35526 hypoglycemic agent
CHEBI has role CHEBI:35705 immunosuppressive agent
CHEBI has role CHEBI:50779 appetite enhancer
CHEBI has role CHEBI:176497 geroprotector

Related Drugs by ATC class:

H01AC Somatropin and somatropin agonists 8 drugs
lonapegsomatropinmecasermin rinfabatesermorelinsomapacitansomatremsomatrogonsomatropintesamorelin

Drug Use | Suggest Off label Use Form| |View source of the data|

DiseaseRelationSNOMED_IDDOID
Laron-type isolated somatotropin defect indication 38196001 DOID:9521




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

None

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])		Mechanism
action		Bioact sourceMoA source
Insulin-like growth factor 1 receptor Kinase AGONIST IC50 8.31 SCIENTIFIC LITERATURE DRUG LABEL
Insulin receptor Kinase IC50 5.85 SCIENTIFIC LITERATURE

External reference:

IDSource
D03297 KEGG_DRUG
4024932 VUID
N0000023113 NUI
4024932 VANDF
CHEBI:749581 CHEBI
CHEMBL1201716 ChEMBL_ID
C000604197 MESH_SUPPLEMENTAL_RECORD_UI
DB01277 DRUGBANK_ID
274403 RXNORM
20506 MMSL
71163 MMSL
d05636 MMSL
011016 NDDF
418157000 SNOMEDCT_US
418845006 SNOMEDCT_US
5699003 SNOMEDCT_US
C0904505 UMLSCUI
6372 INN_ID
4971 IUPHAR_LIGAND_ID
7GR9I2683O UNII

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
Increlex HUMAN PRESCRIPTION DRUG LABEL 1 15054-1040 INJECTION, SOLUTION 40 mg SUBCUTANEOUS BLA 28 sections
Cosmeceutical Mask Pack HUMAN OTC DRUG LABEL 6 60709-102 PATCH 0.04 mg TOPICAL unapproved drug other 9 sections
Dermaheal Cosmeceutical Mask Pack Plus HUMAN OTC DRUG LABEL 6 60709-105 PATCH 0.04 mg TOPICAL unapproved drug other 9 sections
Increlex HUMAN PRESCRIPTION DRUG LABEL 1 71863-216 INJECTION 40 mg SUBCUTANEOUS BLA 32 sections
Increlex HUMAN PRESCRIPTION DRUG LABEL 1 71863-216 INJECTION 40 mg SUBCUTANEOUS BLA 32 sections