mecasermin 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definition	Drug id	CAS RN
insulin-like growth factors	5009	68562-41-4

Description:

Molecule	Description
Synonyms: mecasermin recombinant mecasermin increlex somatomedin C Somatomedin-C IGF1 insulin-like growth factor 1	Recombinant form of endogenous Insulin-like Growth Factor 1 exhibiting mitogenic activity. Clinical Use: Diabetes Mellitus and Amyotrophic Lateral Sclerosis. Molecular weight: 7648.71 Formula: C331H512N94O101S7 CLOGP: LIPINSKI: None HAC: None HDO: None TPSA: 3126.93 ALOGS: ROTB: None

Molecule

Description

Synonyms:

mecasermin recombinant
mecasermin
increlex
somatomedin C
Somatomedin-C
IGF1
insulin-like growth factor 1

Recombinant form of endogenous Insulin-like Growth Factor 1 exhibiting mitogenic activity. Clinical Use: Diabetes Mellitus and Amyotrophic Lateral Sclerosis.

Molecular weight: 7648.71
Formula: C331H512N94O101S7
CLOGP:
LIPINSKI: None
HAC: None
HDO: None
TPSA: 3126.93
ALOGS:
ROTB: None

Drug dosage:

Dose	Unit	Route
2	mg	P

ADMET properties:

None

Approvals:

Date	Agency	Company	Orphan
Aug. 30, 2005	FDA	IPSEN INC
March 8, 2007	EMA

FDA Adverse Event Reporting System (Female)

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MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Hypoglycaemia	61.37	44.31	19	287	60046	63428670

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FDA Adverse Event Reporting System (Male)

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MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Tonsillar hypertrophy	131.92	50.40	21	665	727	34955518
Product dose omission issue	59.95	50.40	34	652	119677	34836568
Adenoidal hypertrophy	54.26	50.40	8	678	163	34956082
Hypoglycaemia	52.06	50.40	24	662	54616	34901629

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FDA Adverse Event Reporting System (Geriatric)

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MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Tonsillar hypertrophy	149.45	39.16	24	879	1538	79741947
Hypoglycaemia	100.37	39.16	39	864	101555	79641930
Product dose omission issue	61.93	39.16	37	866	247500	79495985
Adenoidal hypertrophy	57.72	39.16	8	895	184	79743301
Papilloedema	49.78	39.16	12	891	6221	79737264
Snoring	40.79	39.16	10	893	5556	79737929

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FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

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Source	Code	Description
ATC	H01AC03	SYSTEMIC HORMONAL PREPARATIONS, EXCL. SEX HORMONES AND INSULINS PITUITARY AND HYPOTHALAMIC HORMONES AND ANALOGUES ANTERIOR PITUITARY LOBE HORMONES AND ANALOGUES Somatropin and somatropin agonists
MeSH PA	D006133	Growth Substances

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Drug Use | Suggest Off label Use Form| |View source of the data|

Disease	Relation	SNOMED_ID	DOID
Laron-type isolated somatotropin defect	indication	38196001	DOID:9521

🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

None

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

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Target	Class	Pharos	UniProt	Action	Type	Activity value (-log[M])	Mechanism action	Bioact source	MoA source
Insulin-like growth factor 1 receptor	Kinase	P08069	IGF1R_HUMAN	AGONIST	IC50	8.31		SCIENTIFIC LITERATURE	DRUG LABEL
Insulin receptor	Kinase	P06213	INSR_HUMAN		IC50	5.85		SCIENTIFIC LITERATURE

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External reference:

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ID	Source
011016	NDDF
20506	MMSL
274403	RXNORM
4024932	VUID
4024932	VANDF
418157000	SNOMEDCT_US
418845006	SNOMEDCT_US
4971	IUPHAR_LIGAND_ID
5699003	SNOMEDCT_US
6372	INN_ID

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Pharmaceutical products:

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Product	Category	Ingredients	NDC	Form	Quantity	Route	Marketing	Label
Cosmeceutical Mask Pack	HUMAN OTC DRUG LABEL	6	60709-102	PATCH	0.04 mg	TOPICAL	unapproved drug other	9 sections
Dermaheal Cosmeceutical Mask Pack Plus	HUMAN OTC DRUG LABEL	6	60709-105	PATCH	0.04 mg	TOPICAL	unapproved drug other	9 sections
Increlex	HUMAN PRESCRIPTION DRUG LABEL	1	15054-1040	INJECTION, SOLUTION	40 mg	SUBCUTANEOUS	BLA	30 sections
Increlex	HUMAN PRESCRIPTION DRUG LABEL	1	15054-1040	INJECTION, SOLUTION	40 mg	SUBCUTANEOUS	BLA	30 sections

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