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acotiamide 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | PK/Tox | Related Drugs | BioActivity |
| Stem definition | Drug id | CAS RN |
|---|---|---|
| 4908 | 185106-16-5 |
Description:
| Molecule | Description |
|---|---|
|
Synonyms:
|
A prokinetic agent with gastrointestinal (GI) motility-enhancing activity. Although the exact mechanism by which acotiamide exerts its effect has yet to be fully elucidated, this agent appears to inhibit acetylcholinesterase (AchE), an enzyme responsible for the breakdown of acetylcholine (Ach). Increased Ach concentrations lead to an improvement of gastric emptying and GI motility and eventually to a reduction of dyspepsia symptoms.
|
Drug dosage:
None
ADMET properties:
None
Predicted pharmacokinetic/toxicological properties (PK-AZ):
| Property | Description | Value | Unit | Confidence | Similarity |
|---|---|---|---|---|---|
| kinase-safety-class | ACVR2A,ACVR2B,ALK,AURKA,AXL,BRAF,BTK,CAMK2B,CAMK2D,CDK5,CDK9,CSF1R,DDR1,DYRK1B,EIF2AK3,EPHB4,ERBB2,FLT3,GRK2,IRAK1,ITK,JAK1,JAK2,KIT,MAP3K1,MAP3K21,MAP3K7,MAPK7,MARK4,MET,NTRK2,PDK1,PDK2,PDK4,PIK3CB,PIK3CD,PRKCD,PRKDC,SIK2,SIK3,STK33,SYK,TEK,TTK,ULK1 | 45 | |||
| kinase-selectivity-class | AXL,CAMK2D,DYRK1B,EIF2AK3,EPHB4,GRK2,MAPK7,MARK4,MTOR,PDK4,SIK2,STK33,TEK,TTK,ULK1 | 15 | |||
| pfas-class | PFAS structural alert (1 = True, 0 = False) | 0 |
Approvals:
| Date | Agency | Company | Orphan |
|---|---|---|---|
| March 25, 2013 | PMDA | Zeria |
FDA Adverse Event Reporting System (Female)
None
FDA Adverse Event Reporting System (Male)
None
FDA Adverse Event Reporting System (Geriatric)
None
FDA Adverse Event Reporting System (Pediatric)
None
Pharmacologic Action:
| Source | Code | Description |
|---|---|---|
| ATC | A03FA10 | ALIMENTARY TRACT AND METABOLISM DRUGS FOR FUNCTIONAL GASTROINTESTINAL DISORDERS PROPULSIVES Propulsives |
| MeSH PA | D002800 | Cholinesterase Inhibitors |
| MeSH PA | D004791 | Enzyme Inhibitors |
| MeSH PA | D005765 | Gastrointestinal Agents |
| MeSH PA | D018377 | Neurotransmitter Agents |
| MeSH PA | D018678 | Cholinergic Agents |
Related Drugs by ATC class:
A03FA Propulsives 9 drugs
Drug Use | Suggest Off label Use Form| |View source of the data|
| Disease | Relation | SNOMED_ID | DOID |
|---|---|---|---|
| Nonulcer dyspepsia | indication | 3696007 |
🐶 Veterinary Drug Use
None
🐶 Veterinary products
None
Acid dissociation constants calculated using MoKa v3.0.0
| Dissociation level | Dissociation constant | Type (acidic/basic) |
|---|---|---|
| pKa1 | 9.18 | acidic |
| pKa2 | 9.82 | acidic |
| pKa3 | 13.5 | acidic |
| pKa4 | 10.27 | Basic |
Orange Book patent data (new drug applications)
None
Orange Book exclusivity data (new drug applications)
None
Bioactivity Summary:
| Target | Class | Pharos | UniProt | Action | Type | Activity value (-log[M]) | Mechanism action | Bioact source | MoA source |
|---|---|---|---|---|---|---|---|---|---|
| Acetylcholinesterase | Enzyme | INHIBITOR | IC50 | 5.52 | DRUG LABEL | SCIENTIFIC LITERATURE |
External reference:
| ID | Source |
|---|---|
| D08838 | KEGG_DRUG |
| CHEBI:34523 | CHEBI |
| CHEMBL2107723 | ChEMBL_ID |
| CHEMBL2107308 | ChEMBL_ID |
| C410959 | MESH_SUPPLEMENTAL_RECORD_UI |
| 773092-05-0 | SECONDARY_CAS_RN |
| DB12482 | DRUGBANK_ID |
| C4317155 | UMLSCUI |
| 8506 | INN_ID |
| 5282338 | PUBCHEM_CID |
| D42OWK5383 | UNII |
| D42OWK5383 | INXIGHT DRUGS |
Pharmaceutical products:
None