Stem definition | Drug id | CAS RN |
---|---|---|
sulpiride derivatives | 1782 | 364-62-5 |
Dose | Unit | Route |
---|---|---|
30 | mg | O |
30 | mg | P |
30 | mg | R |
Property | Value | Reference |
---|---|---|
MRTD (Maximum Recommended Therapeutic Daily Dose) | 33.36 ยตM/kg/day | Contrera JF, Matthews EJ, Kruhlak NL, Benz RD |
BDDCS (Biopharmaceutical Drug Disposition Classification System) | 1 | Hosey CM, Chan R, Benet LZ |
S (Water solubility) | 0.20 mg/mL | Hosey CM, Chan R, Benet LZ |
EoM (Fraction excreted unchanged in urine) | 20 % | Hosey CM, Chan R, Benet LZ |
BA (Bioavailability) | 76 % | Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H |
Vd (Volume of distribution) | 3.20 L/kg | Lombardo F, Berellini G, Obach RS |
CL (Clearance) | 5.70 mL/min/kg | Lombardo F, Berellini G, Obach RS |
fu (Fraction unbound in plasma) | 0.60 % | Lombardo F, Berellini G, Obach RS |
t_half (Half-life) | 7.20 hours | Lombardo F, Berellini G, Obach RS |
Date | Agency | Company | Orphan |
---|---|---|---|
Feb. 7, 1979 | FDA | BAXTER HLTHCARE CORP |
MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
---|---|---|---|---|---|---|
Rheumatoid arthritis | 534.01 | 9.97 | 48 | 104290 | 382556 | 55805173 |
Drug ineffective | 515.60 | 9.97 | 570 | 103768 | 918419 | 55269310 |
Vomiting | 482.48 | 9.97 | 2010 | 102328 | 496218 | 55691511 |
Febrile neutropenia | 413.83 | 9.97 | 719 | 103619 | 104826 | 56082903 |
Nausea | 378.00 | 9.97 | 2560 | 101778 | 761618 | 55426111 |
Joint swelling | 305.81 | 9.97 | 80 | 104258 | 289720 | 55898009 |
Drug intolerance | 273.90 | 9.97 | 76 | 104262 | 264742 | 55922987 |
Contraindicated product administered | 263.21 | 9.97 | 22 | 104316 | 186264 | 56001465 |
Arthropathy | 244.87 | 9.97 | 39 | 104299 | 200236 | 55987493 |
Synovitis | 239.48 | 9.97 | 15 | 104323 | 161290 | 56026439 |
Therapeutic product effect decreased | 231.36 | 9.97 | 23 | 104315 | 169429 | 56018300 |
Hand deformity | 229.04 | 9.97 | 4 | 104334 | 134488 | 56053241 |
Systemic lupus erythematosus | 205.13 | 9.97 | 42 | 104296 | 180036 | 56007693 |
Glossodynia | 202.21 | 9.97 | 23 | 104315 | 152435 | 56035294 |
Hypokalaemia | 194.06 | 9.97 | 494 | 103844 | 93943 | 56093786 |
Swelling | 179.97 | 9.97 | 111 | 104227 | 239660 | 55948069 |
Arthralgia | 175.71 | 9.97 | 422 | 103916 | 501247 | 55686482 |
Neutropenic sepsis | 165.77 | 9.97 | 171 | 104167 | 15014 | 56172715 |
Abdominal discomfort | 164.34 | 9.97 | 163 | 104175 | 277111 | 55910618 |
Dystonia | 161.78 | 9.97 | 154 | 104184 | 12267 | 56175462 |
Dehydration | 144.25 | 9.97 | 630 | 103708 | 158195 | 56029534 |
Pericarditis | 142.99 | 9.97 | 17 | 104321 | 108906 | 56078823 |
Wound | 134.03 | 9.97 | 45 | 104293 | 138759 | 56048970 |
Weight increased | 133.82 | 9.97 | 137 | 104201 | 229566 | 55958163 |
Pyrexia | 129.71 | 9.97 | 1264 | 103074 | 417509 | 55770220 |
Abdominal pain | 129.58 | 9.97 | 872 | 103466 | 257933 | 55929796 |
Sinusitis | 129.13 | 9.97 | 106 | 104232 | 197475 | 55990254 |
Neutropenia | 124.78 | 9.97 | 602 | 103736 | 157565 | 56030164 |
Mucosal inflammation | 124.53 | 9.97 | 257 | 104081 | 42553 | 56145176 |
Serotonin syndrome | 121.76 | 9.97 | 194 | 104144 | 26296 | 56161433 |
Hyponatraemia | 120.70 | 9.97 | 440 | 103898 | 101699 | 56086030 |
Product use issue | 118.87 | 9.97 | 102 | 104236 | 185939 | 56001790 |
Hypomagnesaemia | 117.46 | 9.97 | 185 | 104153 | 24830 | 56162899 |
Discomfort | 117.33 | 9.97 | 58 | 104280 | 141703 | 56046026 |
Tardive dyskinesia | 117.01 | 9.97 | 106 | 104232 | 7925 | 56179804 |
Pain | 116.38 | 9.97 | 737 | 103601 | 662447 | 55525282 |
Impaired gastric emptying | 115.26 | 9.97 | 112 | 104226 | 9151 | 56178578 |
Treatment failure | 114.35 | 9.97 | 89 | 104249 | 170303 | 56017426 |
Constipation | 109.90 | 9.97 | 695 | 103643 | 201248 | 55986481 |
Thrombocytopenia | 107.79 | 9.97 | 519 | 103819 | 135705 | 56052024 |
Nasopharyngitis | 107.21 | 9.97 | 152 | 104186 | 220807 | 55966922 |
Extrapyramidal disorder | 106.71 | 9.97 | 123 | 104215 | 12233 | 56175496 |
Duodenal ulcer perforation | 105.58 | 9.97 | 5 | 104333 | 68337 | 56119392 |
Torsade de pointes | 104.36 | 9.97 | 122 | 104216 | 12318 | 56175411 |
Peripheral swelling | 102.86 | 9.97 | 173 | 104165 | 234553 | 55953176 |
Decreased appetite | 102.17 | 9.97 | 726 | 103612 | 218505 | 55969224 |
Injection site pain | 96.78 | 9.97 | 48 | 104290 | 117070 | 56070659 |
General physical health deterioration | 96.78 | 9.97 | 592 | 103746 | 169418 | 56018311 |
Product dose omission issue | 96.23 | 9.97 | 144 | 104194 | 204609 | 55983120 |
Psoriatic arthropathy | 96.01 | 9.97 | 12 | 104326 | 73996 | 56113733 |
Hepatic enzyme increased | 95.54 | 9.97 | 106 | 104232 | 171278 | 56016451 |
Musculoskeletal stiffness | 93.14 | 9.97 | 91 | 104247 | 155916 | 56031813 |
Diarrhoea | 92.53 | 9.97 | 1678 | 102660 | 636829 | 55550900 |
Atelectasis | 92.32 | 9.97 | 144 | 104194 | 19164 | 56168565 |
Helicobacter infection | 87.83 | 9.97 | 15 | 104323 | 73253 | 56114476 |
Anaemia | 85.84 | 9.97 | 814 | 103524 | 266697 | 55921032 |
Toxic epidermal necrolysis | 84.70 | 9.97 | 149 | 104189 | 21893 | 56165836 |
Malignant neoplasm progression | 84.37 | 9.97 | 314 | 104024 | 73273 | 56114456 |
Pulmonary embolism | 83.17 | 9.97 | 406 | 103932 | 106718 | 56081011 |
Electrocardiogram QT prolonged | 78.34 | 9.97 | 251 | 104087 | 54337 | 56133392 |
Psoriasis | 78.08 | 9.97 | 37 | 104301 | 92655 | 56095074 |
Phaeochromocytoma crisis | 76.90 | 9.97 | 25 | 104313 | 208 | 56187521 |
Alopecia | 76.35 | 9.97 | 283 | 104055 | 293175 | 55894554 |
Acute kidney injury | 75.42 | 9.97 | 729 | 103609 | 240034 | 55947695 |
Completed suicide | 73.23 | 9.97 | 84 | 104254 | 133749 | 56053980 |
Parkinsonism | 69.28 | 9.97 | 87 | 104251 | 9459 | 56178270 |
Impaired healing | 68.18 | 9.97 | 38 | 104300 | 86803 | 56100926 |
Computerised tomogram thorax abnormal | 67.40 | 9.97 | 39 | 104299 | 1436 | 56186293 |
Cholecystitis chronic | 64.71 | 9.97 | 85 | 104253 | 9663 | 56178066 |
Hypersensitivity | 64.26 | 9.97 | 251 | 104087 | 256157 | 55931572 |
Sepsis | 62.69 | 9.97 | 459 | 103879 | 139381 | 56048348 |
Gastritis | 62.55 | 9.97 | 173 | 104165 | 34529 | 56153200 |
Neovascularisation | 62.39 | 9.97 | 33 | 104305 | 1016 | 56186713 |
Folliculitis | 60.15 | 9.97 | 14 | 104324 | 54965 | 56132764 |
Neutrophil count decreased | 59.11 | 9.97 | 215 | 104123 | 49607 | 56138122 |
Therapeutic product effect incomplete | 58.60 | 9.97 | 66 | 104272 | 105965 | 56081764 |
Irritable bowel syndrome | 58.15 | 9.97 | 27 | 104311 | 68431 | 56119298 |
Arthritis | 57.57 | 9.97 | 60 | 104278 | 99792 | 56087937 |
Ileus | 57.48 | 9.97 | 97 | 104241 | 13785 | 56173944 |
Cytokine release syndrome | 56.07 | 9.97 | 84 | 104254 | 10791 | 56176938 |
Cardiac arrest | 55.82 | 9.97 | 311 | 104027 | 86003 | 56101726 |
Subileus | 55.41 | 9.97 | 45 | 104293 | 2899 | 56184830 |
Hip arthroplasty | 53.30 | 9.97 | 5 | 104333 | 38618 | 56149111 |
Knee arthroplasty | 53.17 | 9.97 | 9 | 104329 | 44250 | 56143479 |
Hypoxia | 52.86 | 9.97 | 219 | 104119 | 53678 | 56134051 |
Infusion related reaction | 52.66 | 9.97 | 204 | 104134 | 208727 | 55979002 |
Aplastic anaemia | 51.91 | 9.97 | 73 | 104265 | 8855 | 56178874 |
Phaeochromocytoma | 51.84 | 9.97 | 23 | 104315 | 476 | 56187253 |
Restlessness | 50.37 | 9.97 | 135 | 104203 | 26451 | 56161278 |
Oculogyric crisis | 48.50 | 9.97 | 32 | 104306 | 1492 | 56186237 |
Colitis | 47.56 | 9.97 | 178 | 104160 | 41633 | 56146096 |
Electrolyte imbalance | 47.50 | 9.97 | 104 | 104234 | 17929 | 56169800 |
Stevens-Johnson syndrome | 46.95 | 9.97 | 119 | 104219 | 22544 | 56165185 |
Leukopenia | 46.80 | 9.97 | 257 | 104081 | 70683 | 56117046 |
Peripheral circulatory failure | 46.73 | 9.97 | 26 | 104312 | 887 | 56186842 |
Pancytopenia | 46.73 | 9.97 | 303 | 104035 | 88412 | 56099317 |
Contusion | 46.37 | 9.97 | 106 | 104232 | 128324 | 56059405 |
Neuropathy peripheral | 46.25 | 9.97 | 338 | 104000 | 102555 | 56085174 |
Septic shock | 45.36 | 9.97 | 228 | 104110 | 60607 | 56127122 |
C-reactive protein abnormal | 45.31 | 9.97 | 7 | 104331 | 36802 | 56150927 |
Renal ischaemia | 45.10 | 9.97 | 22 | 104316 | 569 | 56187160 |
Injection site bruising | 43.78 | 9.97 | 9 | 104329 | 38512 | 56149217 |
Left ventricular dysfunction | 42.49 | 9.97 | 75 | 104263 | 11048 | 56176681 |
Condition aggravated | 42.23 | 9.97 | 422 | 103916 | 344476 | 55843253 |
Tachycardia | 42.11 | 9.97 | 338 | 104000 | 105538 | 56082191 |
Duodenal stenosis | 42.10 | 9.97 | 20 | 104318 | 487 | 56187242 |
Encephalopathy | 41.53 | 9.97 | 152 | 104186 | 35173 | 56152556 |
Pleural effusion | 41.44 | 9.97 | 286 | 104052 | 85194 | 56102535 |
Blood cholesterol increased | 40.29 | 9.97 | 45 | 104293 | 72534 | 56115195 |
Rash | 40.04 | 9.97 | 658 | 103680 | 492389 | 55695340 |
Cholecystitis | 40.02 | 9.97 | 85 | 104253 | 14350 | 56173379 |
Adverse drug reaction | 40.00 | 9.97 | 37 | 104301 | 65095 | 56122634 |
Device expulsion | 39.33 | 9.97 | 5 | 104333 | 30444 | 56157285 |
Ejection fraction decreased | 38.85 | 9.97 | 102 | 104236 | 19739 | 56167990 |
Red blood cell sedimentation rate increased | 38.75 | 9.97 | 10 | 104328 | 36613 | 56151116 |
Computerised tomogram thorax | 38.59 | 9.97 | 15 | 104323 | 219 | 56187510 |
PCO2 increased | 38.33 | 9.97 | 25 | 104313 | 1143 | 56186586 |
Dyskinesia | 38.31 | 9.97 | 130 | 104208 | 28978 | 56158751 |
Adverse event | 38.29 | 9.97 | 28 | 104310 | 55348 | 56132381 |
PO2 increased | 38.14 | 9.97 | 22 | 104316 | 805 | 56186924 |
Osteoarthritis | 37.16 | 9.97 | 57 | 104281 | 80239 | 56107490 |
Diabetes insipidus | 37.15 | 9.97 | 33 | 104305 | 2404 | 56185325 |
Rash maculo-papular | 37.08 | 9.97 | 128 | 104210 | 28779 | 56158950 |
Ventricular fibrillation | 36.96 | 9.97 | 70 | 104268 | 10882 | 56176847 |
Injection site erythema | 36.79 | 9.97 | 54 | 104284 | 77394 | 56110335 |
Aplasia | 36.57 | 9.97 | 41 | 104297 | 3955 | 56183774 |
Dysphagia | 36.13 | 9.97 | 268 | 104070 | 81679 | 56106050 |
Mouth ulceration | 36.08 | 9.97 | 129 | 104209 | 29511 | 56158218 |
Malnutrition | 36.00 | 9.97 | 80 | 104258 | 13928 | 56173801 |
Excessive eye blinking | 35.77 | 9.97 | 23 | 104315 | 1026 | 56186703 |
Blood bicarbonate decreased | 35.66 | 9.97 | 34 | 104304 | 2712 | 56185017 |
Hepatocellular injury | 35.41 | 9.97 | 119 | 104219 | 26395 | 56161334 |
Cholestasis | 35.24 | 9.97 | 120 | 104218 | 26793 | 56160936 |
Disease progression | 35.12 | 9.97 | 323 | 104015 | 104850 | 56082879 |
Therapeutic response decreased | 34.79 | 9.97 | 28 | 104310 | 52730 | 56134999 |
Gastroenteritis | 34.78 | 9.97 | 112 | 104226 | 24300 | 56163429 |
Injection site reaction | 34.20 | 9.97 | 29 | 104309 | 53218 | 56134511 |
Ascites | 34.06 | 9.97 | 149 | 104189 | 37395 | 56150334 |
Peritonitis | 33.48 | 9.97 | 85 | 104253 | 16117 | 56171612 |
Wrong technique in product usage process | 33.46 | 9.97 | 35 | 104303 | 58133 | 56129596 |
Haematemesis | 33.18 | 9.97 | 123 | 104215 | 28635 | 56159094 |
Hypotension | 33.15 | 9.97 | 650 | 103688 | 249858 | 55937871 |
Mobility decreased | 33.12 | 9.97 | 85 | 104253 | 98906 | 56088823 |
Abortion spontaneous | 33.12 | 9.97 | 20 | 104318 | 43733 | 56143996 |
Injection site swelling | 32.87 | 9.97 | 20 | 104318 | 43558 | 56144171 |
Blood pressure increased | 32.68 | 9.97 | 148 | 104190 | 145028 | 56042701 |
Akathisia | 32.61 | 9.97 | 58 | 104280 | 8594 | 56179135 |
Small intestinal obstruction | 32.44 | 9.97 | 86 | 104252 | 16739 | 56170990 |
Drug interaction | 31.83 | 9.97 | 556 | 103782 | 209199 | 55978530 |
Emotional distress | 31.62 | 9.97 | 124 | 104214 | 29639 | 56158090 |
Intentional product use issue | 31.58 | 9.97 | 88 | 104250 | 99645 | 56088084 |
Therapy non-responder | 30.92 | 9.97 | 41 | 104297 | 61314 | 56126415 |
Hyperprolactinaemia | 30.86 | 9.97 | 36 | 104302 | 3625 | 56184104 |
Blood magnesium decreased | 30.73 | 9.97 | 68 | 104270 | 11806 | 56175923 |
Injection site pruritus | 30.59 | 9.97 | 20 | 104318 | 41911 | 56145818 |
Urticaria | 30.51 | 9.97 | 151 | 104187 | 144525 | 56043204 |
Asthma | 29.76 | 9.97 | 108 | 104230 | 112662 | 56075067 |
Gamma-glutamyltransferase increased | 29.63 | 9.97 | 125 | 104213 | 30880 | 56156849 |
Ill-defined disorder | 29.52 | 9.97 | 51 | 104287 | 68492 | 56119237 |
Polydipsia | 29.28 | 9.97 | 33 | 104305 | 3202 | 56184527 |
Antinuclear antibody negative | 29.21 | 9.97 | 12 | 104326 | 204 | 56187525 |
Hypocalcaemia | 29.09 | 9.97 | 118 | 104220 | 28642 | 56159087 |
Mixed liver injury | 28.71 | 9.97 | 36 | 104302 | 3908 | 56183821 |
Urinary retention | 28.25 | 9.97 | 115 | 104223 | 27959 | 56159770 |
Erysipelas | 28.02 | 9.97 | 49 | 104289 | 7164 | 56180565 |
Paradoxical drug reaction | 28.02 | 9.97 | 35 | 104303 | 3785 | 56183944 |
Respiratory syncytial virus infection | 27.89 | 9.97 | 42 | 104296 | 5419 | 56182310 |
Accidental exposure to product | 27.51 | 9.97 | 6 | 104332 | 24641 | 56163088 |
Heart rate decreased | 27.23 | 9.97 | 21 | 104317 | 40406 | 56147323 |
Alveolitis | 27.20 | 9.97 | 29 | 104309 | 2644 | 56185085 |
Immune effector cell-associated neurotoxicity syndrome | 26.98 | 9.97 | 23 | 104315 | 1585 | 56186144 |
Coombs positive haemolytic anaemia | 26.83 | 9.97 | 13 | 104325 | 331 | 56187398 |
Influenza | 26.63 | 9.97 | 89 | 104249 | 95172 | 56092557 |
Abdominal pain upper | 26.45 | 9.97 | 471 | 103867 | 177842 | 56009887 |
Loss of personal independence in daily activities | 26.36 | 9.97 | 71 | 104267 | 81298 | 56106431 |
Pancreatitis | 26.24 | 9.97 | 158 | 104180 | 44922 | 56142807 |
Oesophagitis | 26.24 | 9.97 | 71 | 104267 | 13986 | 56173743 |
Maternal exposure during pregnancy | 26.14 | 9.97 | 225 | 104113 | 189328 | 55998401 |
Pain in extremity | 26.09 | 9.97 | 391 | 103947 | 297040 | 55890689 |
Urosepsis | 25.94 | 9.97 | 79 | 104259 | 16637 | 56171092 |
Blood pressure fluctuation | 25.90 | 9.97 | 22 | 104316 | 40338 | 56147391 |
Infusion site streaking | 25.64 | 9.97 | 14 | 104324 | 460 | 56187269 |
Respiratory dyskinesia | 25.64 | 9.97 | 7 | 104331 | 29 | 56187700 |
Skin candida | 25.56 | 9.97 | 21 | 104317 | 1375 | 56186354 |
Respiratory failure | 25.48 | 9.97 | 279 | 104059 | 94783 | 56092946 |
Cholelithiasis | 25.37 | 9.97 | 142 | 104196 | 39322 | 56148407 |
Dyspnoea | 25.31 | 9.97 | 1341 | 102997 | 591236 | 55596493 |
Blood pH decreased | 25.28 | 9.97 | 27 | 104311 | 2467 | 56185262 |
Onychalgia | 25.03 | 9.97 | 17 | 104321 | 832 | 56186897 |
Secondary adrenocortical insufficiency | 25.01 | 9.97 | 20 | 104318 | 1260 | 56186469 |
Nail infection | 24.78 | 9.97 | 26 | 104312 | 2327 | 56185402 |
Multiple organ dysfunction syndrome | 24.65 | 9.97 | 175 | 104163 | 52595 | 56135134 |
Neuroleptic malignant syndrome | 24.54 | 9.97 | 61 | 104277 | 11417 | 56176312 |
Fibromyalgia | 24.19 | 9.97 | 46 | 104292 | 59557 | 56128172 |
Cataract | 24.08 | 9.97 | 36 | 104302 | 51211 | 56136518 |
Deep vein thrombosis | 23.99 | 9.97 | 233 | 104105 | 76744 | 56110985 |
Hyponatraemic seizure | 23.95 | 9.97 | 13 | 104325 | 422 | 56187307 |
Duodenal perforation | 23.56 | 9.97 | 16 | 104322 | 783 | 56186946 |
Febrile bone marrow aplasia | 23.42 | 9.97 | 43 | 104295 | 6529 | 56181200 |
Pituitary tumour benign | 23.40 | 9.97 | 23 | 104315 | 1905 | 56185824 |
Gastritis haemorrhagic | 23.21 | 9.97 | 20 | 104318 | 1399 | 56186330 |
Foetal death | 23.16 | 9.97 | 50 | 104288 | 8537 | 56179192 |
Pancreatitis acute | 23.01 | 9.97 | 100 | 104238 | 25024 | 56162705 |
Gelastic seizure | 23.01 | 9.97 | 5 | 104333 | 5 | 56187724 |
Infection | 22.81 | 9.97 | 249 | 104089 | 199957 | 55987772 |
Multiple drug therapy | 22.78 | 9.97 | 27 | 104311 | 2765 | 56184964 |
Disturbance in social behaviour | 22.52 | 9.97 | 28 | 104310 | 3013 | 56184716 |
Agitation | 22.32 | 9.97 | 179 | 104159 | 55857 | 56131872 |
Herpes simplex reactivation | 22.26 | 9.97 | 13 | 104325 | 487 | 56187242 |
Enterocolitis | 22.26 | 9.97 | 44 | 104294 | 7060 | 56180669 |
Hypophagia | 22.06 | 9.97 | 109 | 104229 | 28767 | 56158962 |
Pneumonitis | 21.92 | 9.97 | 116 | 104222 | 31448 | 56156281 |
Dyspepsia | 21.92 | 9.97 | 244 | 104094 | 83227 | 56104502 |
Brain oedema | 21.80 | 9.97 | 64 | 104274 | 13207 | 56174522 |
Carcinoid tumour of the stomach | 21.80 | 9.97 | 9 | 104329 | 155 | 56187574 |
Hypergastrinaemia | 21.70 | 9.97 | 8 | 104330 | 100 | 56187629 |
Seizure | 21.67 | 9.97 | 339 | 103999 | 124780 | 56062949 |
Enterochromaffin cell hyperplasia | 21.66 | 9.97 | 7 | 104331 | 57 | 56187672 |
Aquagenic pruritus | 21.58 | 9.97 | 6 | 104332 | 27 | 56187702 |
Pneumonia | 21.07 | 9.97 | 939 | 103399 | 406159 | 55781570 |
Fatigue | 20.91 | 9.97 | 1223 | 103115 | 787329 | 55400400 |
Lethargy | 20.86 | 9.97 | 165 | 104173 | 51276 | 56136453 |
No adverse event | 20.79 | 9.97 | 22 | 104316 | 36352 | 56151377 |
Delusional disorder, persecutory type | 20.70 | 9.97 | 9 | 104329 | 177 | 56187552 |
Long QT syndrome | 20.69 | 9.97 | 27 | 104311 | 3049 | 56184680 |
Malignant polyp | 20.52 | 9.97 | 9 | 104329 | 181 | 56187548 |
Joint injury | 20.45 | 9.97 | 11 | 104327 | 25643 | 56162086 |
Electrocardiogram T wave inversion | 20.43 | 9.97 | 28 | 104310 | 3315 | 56184414 |
Radiation pneumonitis | 20.42 | 9.97 | 19 | 104319 | 1470 | 56186259 |
Grip strength decreased | 20.21 | 9.97 | 3 | 104335 | 16253 | 56171476 |
Intestinal perforation | 20.10 | 9.97 | 55 | 104283 | 10904 | 56176825 |
Inappropriate schedule of product administration | 19.98 | 9.97 | 83 | 104255 | 83304 | 56104425 |
Blood alkaline phosphatase increased | 19.87 | 9.97 | 132 | 104206 | 38813 | 56148916 |
Obstruction gastric | 19.75 | 9.97 | 15 | 104323 | 876 | 56186853 |
Thirst | 19.69 | 9.97 | 55 | 104283 | 11035 | 56176694 |
Thymus disorder | 19.61 | 9.97 | 10 | 104328 | 285 | 56187444 |
Clonus | 19.36 | 9.97 | 31 | 104307 | 4218 | 56183511 |
Torticollis | 19.31 | 9.97 | 20 | 104318 | 1763 | 56185966 |
Plantar erythema | 19.14 | 9.97 | 9 | 104329 | 214 | 56187515 |
Eructation | 19.12 | 9.97 | 43 | 104295 | 7545 | 56180184 |
Anxiety disorder | 18.97 | 9.97 | 29 | 104309 | 3791 | 56183938 |
Fall | 18.96 | 9.97 | 511 | 103827 | 356999 | 55830730 |
Acute interstitial pneumonitis | 18.86 | 9.97 | 13 | 104325 | 652 | 56187077 |
Oxygen saturation abnormal | 18.85 | 9.97 | 25 | 104313 | 2869 | 56184860 |
Acute abdomen | 18.65 | 9.97 | 18 | 104320 | 1458 | 56186271 |
Hepatic failure | 18.63 | 9.97 | 116 | 104222 | 33370 | 56154359 |
Nervous system disorder | 18.46 | 9.97 | 71 | 104267 | 16818 | 56170911 |
Catheter site bruise | 18.44 | 9.97 | 10 | 104328 | 324 | 56187405 |
Aortic rupture | 18.34 | 9.97 | 7 | 104331 | 97 | 56187632 |
Hypochloraemia | 18.18 | 9.97 | 19 | 104319 | 1693 | 56186036 |
Bone erosion | 18.08 | 9.97 | 3 | 104335 | 14971 | 56172758 |
Blood pressure systolic increased | 17.94 | 9.97 | 30 | 104308 | 40806 | 56146923 |
Sinus disorder | 17.88 | 9.97 | 8 | 104330 | 20726 | 56167003 |
Hypoglycaemic seizure | 17.70 | 9.97 | 11 | 104327 | 462 | 56187267 |
Vitamin B12 decreased | 17.66 | 9.97 | 25 | 104313 | 3050 | 56184679 |
Haemorrhoids | 17.43 | 9.97 | 79 | 104259 | 20127 | 56167602 |
Hypoalbuminaemia | 17.30 | 9.97 | 51 | 104287 | 10548 | 56177181 |
Herpes zoster | 17.28 | 9.97 | 77 | 104261 | 75812 | 56111917 |
Premature baby | 17.25 | 9.97 | 76 | 104262 | 19129 | 56168600 |
COVID-19 | 17.19 | 9.97 | 76 | 104262 | 74982 | 56112747 |
Gait disturbance | 17.09 | 9.97 | 207 | 104131 | 163114 | 56024615 |
Presyncope | 17.07 | 9.97 | 93 | 104245 | 25489 | 56162240 |
Inflammation | 17.02 | 9.97 | 68 | 104270 | 69003 | 56118726 |
Nasal congestion | 16.92 | 9.97 | 51 | 104287 | 56319 | 56131410 |
Intestinal obstruction | 16.90 | 9.97 | 99 | 104239 | 27872 | 56159857 |
Intentional overdose | 16.82 | 9.97 | 67 | 104271 | 68050 | 56119679 |
Dysuria | 16.81 | 9.97 | 106 | 104232 | 30623 | 56157106 |
Gallbladder injury | 16.70 | 9.97 | 16 | 104322 | 1284 | 56186445 |
Staring | 16.58 | 9.97 | 17 | 104321 | 1481 | 56186248 |
Joint stiffness | 16.53 | 9.97 | 25 | 104313 | 35400 | 56152329 |
Hypoaesthesia | 16.50 | 9.97 | 175 | 104163 | 141316 | 56046413 |
Cystitis noninfective | 16.48 | 9.97 | 14 | 104324 | 960 | 56186769 |
Biliary dyskinesia | 16.47 | 9.97 | 22 | 104316 | 2541 | 56185188 |
Sleep disorder | 16.43 | 9.97 | 67 | 104271 | 67596 | 56120133 |
Prescribed underdose | 16.20 | 9.97 | 9 | 104329 | 20608 | 56167121 |
Neuroglycopenia | 16.20 | 9.97 | 10 | 104328 | 415 | 56187314 |
Hypophosphataemia | 16.14 | 9.97 | 47 | 104291 | 9655 | 56178074 |
Diabetic gastroparesis | 16.12 | 9.97 | 8 | 104330 | 215 | 56187514 |
Drug resistance | 16.10 | 9.97 | 9 | 104329 | 20533 | 56167196 |
Renal failure | 16.06 | 9.97 | 291 | 104047 | 110209 | 56077520 |
Haemangioma of skin | 15.94 | 9.97 | 9 | 104329 | 316 | 56187413 |
Headache | 15.87 | 9.97 | 861 | 103477 | 558183 | 55629546 |
Gastrointestinal stoma complication | 15.87 | 9.97 | 17 | 104321 | 1558 | 56186171 |
Hiccups | 15.85 | 9.97 | 19 | 104319 | 1969 | 56185760 |
Blood bilirubin increased | 15.80 | 9.97 | 111 | 104227 | 33243 | 56154486 |
Sciatica | 15.70 | 9.97 | 15 | 104323 | 25995 | 56161734 |
Ileus paralytic | 15.65 | 9.97 | 28 | 104310 | 4167 | 56183562 |
Injection site haemorrhage | 15.64 | 9.97 | 11 | 104327 | 22190 | 56165539 |
Gastric polyps | 15.49 | 9.97 | 24 | 104314 | 3174 | 56184555 |
Cancer pain | 15.30 | 9.97 | 23 | 104315 | 2963 | 56184766 |
Bronchitis | 15.17 | 9.97 | 134 | 104204 | 112177 | 56075552 |
Blister | 15.11 | 9.97 | 129 | 104209 | 108758 | 56078971 |
Generalised tonic-clonic seizure | 15.02 | 9.97 | 95 | 104243 | 27471 | 56160258 |
Anuria | 15.01 | 9.97 | 52 | 104286 | 11708 | 56176021 |
Granulocytopenia neonatal | 14.76 | 9.97 | 4 | 104334 | 16 | 56187713 |
Blood creatinine increased | 14.54 | 9.97 | 219 | 104119 | 79972 | 56107757 |
Aspiration | 14.49 | 9.97 | 45 | 104293 | 9576 | 56178153 |
Bone density decreased | 14.46 | 9.97 | 3 | 104335 | 12757 | 56174972 |
Pruritus | 14.42 | 9.97 | 462 | 103876 | 316161 | 55871568 |
Aspartate aminotransferase increased | 14.37 | 9.97 | 224 | 104114 | 82378 | 56105351 |
Palmar-plantar erythrodysaesthesia syndrome | 14.34 | 9.97 | 77 | 104261 | 20988 | 56166741 |
Vascular encephalopathy | 14.34 | 9.97 | 9 | 104329 | 385 | 56187344 |
Immunodeficiency | 14.30 | 9.97 | 6 | 104332 | 16151 | 56171578 |
Hospitalisation | 14.28 | 9.97 | 81 | 104257 | 74919 | 56112810 |
Bezoar | 14.20 | 9.97 | 15 | 104323 | 1353 | 56186376 |
Rectal haemorrhage | 14.16 | 9.97 | 128 | 104210 | 41339 | 56146390 |
Vagus nerve disorder | 14.09 | 9.97 | 6 | 104332 | 112 | 56187617 |
Foot deformity | 14.08 | 9.97 | 14 | 104324 | 23811 | 56163918 |
Joint effusion | 14.07 | 9.97 | 5 | 104333 | 14893 | 56172836 |
Hyperkalaemia | 13.95 | 9.97 | 150 | 104188 | 50715 | 56137014 |
Bradykinesia | 13.94 | 9.97 | 29 | 104309 | 4825 | 56182904 |
Meconium ileus | 13.80 | 9.97 | 3 | 104335 | 3 | 56187726 |
Alanine aminotransferase increased | 13.73 | 9.97 | 247 | 104091 | 93415 | 56094314 |
Hydronephrosis | 13.71 | 9.97 | 43 | 104295 | 9199 | 56178530 |
Platelet count decreased | 13.69 | 9.97 | 275 | 104063 | 106108 | 56081621 |
Leukoencephalopathy | 13.66 | 9.97 | 26 | 104312 | 4056 | 56183673 |
Type 2 diabetes mellitus | 13.64 | 9.97 | 43 | 104295 | 46819 | 56140910 |
Leukocytosis | 13.60 | 9.97 | 83 | 104255 | 23708 | 56164021 |
Cachexia | 13.58 | 9.97 | 29 | 104309 | 4913 | 56182816 |
Naevus haemorrhage | 13.58 | 9.97 | 6 | 104332 | 123 | 56187606 |
Gastrointestinal submucosal tumour | 13.58 | 9.97 | 4 | 104334 | 23 | 56187706 |
Muscle contracture | 13.56 | 9.97 | 14 | 104324 | 1230 | 56186499 |
Myoclonus | 13.53 | 9.97 | 60 | 104278 | 15143 | 56172586 |
Throat irritation | 13.46 | 9.97 | 25 | 104313 | 32658 | 56155071 |
Neuroendocrine tumour | 13.42 | 9.97 | 11 | 104327 | 718 | 56187011 |
Bursitis | 13.32 | 9.97 | 19 | 104319 | 27563 | 56160166 |
Dermatitis exfoliative | 13.32 | 9.97 | 30 | 104308 | 5269 | 56182460 |
Paranoia | 13.28 | 9.97 | 47 | 104291 | 10697 | 56177032 |
Product storage error | 13.25 | 9.97 | 4 | 104334 | 13209 | 56174520 |
Wheezing | 13.24 | 9.97 | 83 | 104255 | 74943 | 56112786 |
Hypoglycaemia | 13.24 | 9.97 | 160 | 104178 | 55655 | 56132074 |
Granulomatous liver disease | 13.22 | 9.97 | 11 | 104327 | 733 | 56186996 |
Economic problem | 13.21 | 9.97 | 17 | 104321 | 1894 | 56185835 |
Multiple sclerosis relapse | 13.21 | 9.97 | 41 | 104297 | 44862 | 56142867 |
Neoplasm progression | 13.15 | 9.97 | 103 | 104235 | 31913 | 56155816 |
Tumour pain | 13.13 | 9.97 | 14 | 104324 | 1277 | 56186452 |
Drug dependence | 13.13 | 9.97 | 79 | 104259 | 22454 | 56165275 |
Blood pressure diastolic decreased | 13.06 | 9.97 | 10 | 104328 | 19313 | 56168416 |
Methaemoglobinaemia | 13.05 | 9.97 | 18 | 104320 | 2144 | 56185585 |
Patent ductus arteriosus | 13.02 | 9.97 | 25 | 104313 | 3926 | 56183803 |
Flail chest | 12.99 | 9.97 | 5 | 104333 | 71 | 56187658 |
Hyperglycaemia | 12.99 | 9.97 | 118 | 104220 | 38163 | 56149566 |
Catatonia | 12.96 | 9.97 | 25 | 104313 | 3939 | 56183790 |
Muscle twitching | 12.90 | 9.97 | 62 | 104276 | 16180 | 56171549 |
Hyperthyroidism | 12.89 | 9.97 | 54 | 104284 | 13298 | 56174431 |
Illness | 12.84 | 9.97 | 28 | 104310 | 34483 | 56153246 |
Myalgia | 12.81 | 9.97 | 170 | 104168 | 131855 | 56055874 |
Thoracic operation | 12.79 | 9.97 | 6 | 104332 | 142 | 56187587 |
Premature delivery | 12.78 | 9.97 | 90 | 104248 | 26970 | 56160759 |
Carpal tunnel syndrome | 12.77 | 9.97 | 9 | 104329 | 18135 | 56169594 |
Abdominal tenderness | 12.76 | 9.97 | 37 | 104301 | 7584 | 56180145 |
Joint range of motion decreased | 12.73 | 9.97 | 17 | 104321 | 25348 | 56162381 |
Amylase increased | 12.68 | 9.97 | 31 | 104307 | 5740 | 56181989 |
Drug tolerance increased | 12.68 | 9.97 | 7 | 104331 | 235 | 56187494 |
Foot fracture | 12.68 | 9.97 | 13 | 104325 | 21796 | 56165933 |
Muscle spasticity | 12.66 | 9.97 | 11 | 104327 | 19949 | 56167780 |
Escherichia test positive | 12.65 | 9.97 | 18 | 104320 | 2207 | 56185522 |
Visual impairment | 12.63 | 9.97 | 83 | 104255 | 74119 | 56113610 |
Electrocardiogram change | 12.62 | 9.97 | 10 | 104328 | 622 | 56187107 |
Feeling abnormal | 12.61 | 9.97 | 173 | 104165 | 133429 | 56054300 |
Lower respiratory tract infection | 12.58 | 9.97 | 144 | 104194 | 114650 | 56073079 |
Gaze palsy | 12.57 | 9.97 | 14 | 104324 | 1341 | 56186388 |
Basal cell carcinoma | 12.56 | 9.97 | 17 | 104321 | 25204 | 56162525 |
Lung perforation | 12.50 | 9.97 | 5 | 104333 | 79 | 56187650 |
Drug clearance decreased | 12.49 | 9.97 | 14 | 104324 | 1350 | 56186379 |
Chronic sinusitis | 12.45 | 9.97 | 39 | 104299 | 8339 | 56179390 |
Pulmonary air leakage | 12.44 | 9.97 | 4 | 104334 | 32 | 56187697 |
Hyperhidrosis | 12.37 | 9.97 | 244 | 104094 | 93844 | 56093885 |
Stridor | 12.30 | 9.97 | 22 | 104316 | 3273 | 56184456 |
Nephritis allergic | 12.27 | 9.97 | 6 | 104332 | 156 | 56187573 |
Premature labour | 12.21 | 9.97 | 49 | 104289 | 11833 | 56175896 |
Oesophageal ulcer | 12.21 | 9.97 | 25 | 104313 | 4114 | 56183615 |
Non-cardiac chest pain | 12.18 | 9.97 | 31 | 104307 | 5885 | 56181844 |
Circulatory collapse | 12.16 | 9.97 | 73 | 104265 | 20730 | 56166999 |
Antiphospholipid syndrome | 12.12 | 9.97 | 15 | 104323 | 1606 | 56186123 |
Lung infiltration | 12.06 | 9.97 | 54 | 104284 | 13684 | 56174045 |
Inappropriate antidiuretic hormone secretion | 12.02 | 9.97 | 54 | 104284 | 13702 | 56174027 |
Ear infection | 11.97 | 9.97 | 25 | 104313 | 31270 | 56156459 |
Porphyria | 11.90 | 9.97 | 6 | 104332 | 167 | 56187562 |
Peripheral sensory neuropathy | 11.86 | 9.97 | 34 | 104304 | 6922 | 56180807 |
Anaphylactic reaction | 11.84 | 9.97 | 164 | 104174 | 58831 | 56128898 |
Muscle rigidity | 11.77 | 9.97 | 45 | 104293 | 10626 | 56177103 |
Gastrointestinal necrosis | 11.74 | 9.97 | 19 | 104319 | 2607 | 56185122 |
Chronic fatigue syndrome | 11.63 | 9.97 | 12 | 104326 | 1053 | 56186676 |
Musculoskeletal disorder | 11.61 | 9.97 | 11 | 104327 | 19136 | 56168593 |
Product quality issue | 11.60 | 9.97 | 26 | 104312 | 31710 | 56156019 |
Face oedema | 11.59 | 9.97 | 66 | 104272 | 18386 | 56169343 |
Vascular pain | 11.57 | 9.97 | 10 | 104328 | 702 | 56187027 |
Diabetes mellitus inadequate control | 11.57 | 9.97 | 54 | 104284 | 13926 | 56173803 |
Blood cholesterol decreased | 11.55 | 9.97 | 11 | 104327 | 876 | 56186853 |
Device dislocation | 11.50 | 9.97 | 15 | 104323 | 22591 | 56165138 |
Lip erosion | 11.48 | 9.97 | 11 | 104327 | 883 | 56186846 |
Restless arm syndrome | 11.39 | 9.97 | 4 | 104334 | 43 | 56187686 |
Device malfunction | 11.36 | 9.97 | 8 | 104330 | 16128 | 56171601 |
Pregnancy | 11.33 | 9.97 | 28 | 104310 | 33005 | 56154724 |
Mucosal erosion | 11.23 | 9.97 | 13 | 104325 | 1298 | 56186431 |
Reflux gastritis | 11.22 | 9.97 | 12 | 104326 | 1098 | 56186631 |
Hyperpyrexia | 11.17 | 9.97 | 21 | 104317 | 3247 | 56184482 |
Abdominal distension | 11.12 | 9.97 | 204 | 104134 | 77422 | 56110307 |
Prolactin-producing pituitary tumour | 11.12 | 9.97 | 5 | 104333 | 107 | 56187622 |
Urea urine increased | 11.07 | 9.97 | 3 | 104335 | 12 | 56187717 |
Abdominal mass | 11.07 | 9.97 | 19 | 104319 | 2736 | 56184993 |
Peptic ulcer | 11.03 | 9.97 | 24 | 104314 | 4120 | 56183609 |
Transfusion | 11.02 | 9.97 | 52 | 104286 | 13468 | 56174261 |
Leukostasis syndrome | 11.00 | 9.97 | 4 | 104334 | 48 | 56187681 |
Parkinson's disease | 10.97 | 9.97 | 13 | 104325 | 1331 | 56186398 |
Urinary tract infection | 10.96 | 9.97 | 548 | 103790 | 239965 | 55947764 |
Memory impairment | 10.94 | 9.97 | 105 | 104233 | 86452 | 56101277 |
Tracheal injury | 10.93 | 9.97 | 4 | 104334 | 49 | 56187680 |
Myocardial reperfusion injury | 10.93 | 9.97 | 4 | 104334 | 49 | 56187680 |
Confusional state | 10.92 | 9.97 | 481 | 103857 | 207674 | 55980055 |
Joint dislocation | 10.87 | 9.97 | 8 | 104330 | 15765 | 56171964 |
Pneumoperitoneum | 10.84 | 9.97 | 13 | 104325 | 1348 | 56186381 |
Sinus tachycardia | 10.81 | 9.97 | 75 | 104263 | 22369 | 56165360 |
Suicide attempt | 10.72 | 9.97 | 63 | 104275 | 57773 | 56129956 |
Epilepsy congenital | 10.70 | 9.97 | 3 | 104335 | 14 | 56187715 |
Non-small cell lung cancer | 10.68 | 9.97 | 22 | 104316 | 3636 | 56184093 |
Rhinorrhoea | 10.64 | 9.97 | 62 | 104276 | 56975 | 56130754 |
Opisthotonus | 10.64 | 9.97 | 7 | 104331 | 325 | 56187404 |
Respiratory tract congestion | 10.63 | 9.97 | 8 | 104330 | 15583 | 56172146 |
Sinus arrhythmia | 10.61 | 9.97 | 13 | 104325 | 1378 | 56186351 |
Coeliac disease | 10.60 | 9.97 | 3 | 104335 | 10336 | 56177393 |
Starvation | 10.59 | 9.97 | 6 | 104332 | 212 | 56187517 |
Terminal ileitis | 10.59 | 9.97 | 9 | 104329 | 618 | 56187111 |
Head titubation | 10.56 | 9.97 | 10 | 104328 | 791 | 56186938 |
Peritoneal perforation | 10.55 | 9.97 | 5 | 104333 | 121 | 56187608 |
Intercepted product administration error | 10.55 | 9.97 | 5 | 104333 | 121 | 56187608 |
Cholecystitis acute | 10.54 | 9.97 | 34 | 104304 | 7382 | 56180347 |
Dementia | 10.54 | 9.97 | 61 | 104277 | 17097 | 56170632 |
Urinary tract infection enterococcal | 10.49 | 9.97 | 18 | 104320 | 2591 | 56185138 |
Foetal malpresentation | 10.48 | 9.97 | 5 | 104333 | 123 | 56187606 |
Labelled drug-drug interaction issue | 10.45 | 9.97 | 10 | 104328 | 801 | 56186928 |
Adrenal insufficiency | 10.43 | 9.97 | 57 | 104281 | 15640 | 56172089 |
Urinary tract obstruction | 10.41 | 9.97 | 15 | 104323 | 1860 | 56185869 |
Vocal cord paresis | 10.33 | 9.97 | 5 | 104333 | 127 | 56187602 |
Apallic syndrome | 10.33 | 9.97 | 9 | 104329 | 639 | 56187090 |
Nephrocalcinosis | 10.31 | 9.97 | 11 | 104327 | 1004 | 56186725 |
Subacute combined cord degeneration | 10.29 | 9.97 | 6 | 104332 | 224 | 56187505 |
Syncope | 10.27 | 9.97 | 268 | 104070 | 107931 | 56079798 |
Ultrasound abdomen abnormal | 10.25 | 9.97 | 4 | 104334 | 59 | 56187670 |
Therapy cessation | 10.24 | 9.97 | 22 | 104316 | 27242 | 56160487 |
Peripheral venous disease | 10.20 | 9.97 | 3 | 104335 | 10076 | 56177653 |
Off label use | 10.19 | 9.97 | 890 | 103448 | 555290 | 55632439 |
PCO2 decreased | 10.19 | 9.97 | 12 | 104326 | 1221 | 56186508 |
Motion sickness | 10.17 | 9.97 | 10 | 104328 | 829 | 56186900 |
Malignant pleural effusion | 10.16 | 9.97 | 17 | 104321 | 2399 | 56185330 |
Catheter site related reaction | 10.16 | 9.97 | 10 | 104328 | 830 | 56186899 |
Bundle branch block | 10.14 | 9.97 | 10 | 104328 | 832 | 56186897 |
Metastases to central nervous system | 10.13 | 9.97 | 47 | 104291 | 12089 | 56175640 |
Tooth disorder | 10.12 | 9.97 | 20 | 104318 | 25533 | 56162196 |
Road traffic accident | 10.11 | 9.97 | 23 | 104315 | 27904 | 56159825 |
Gastrointestinal mucosal exfoliation | 10.09 | 9.97 | 5 | 104333 | 134 | 56187595 |
Supraventricular tachycardia | 10.03 | 9.97 | 50 | 104288 | 13241 | 56174488 |
MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
---|---|---|---|---|---|---|
Febrile neutropenia | 405.63 | 10.34 | 802 | 61908 | 121047 | 31513587 |
Vomiting | 286.40 | 10.34 | 1032 | 61678 | 222941 | 31411693 |
Nausea | 245.07 | 10.34 | 1228 | 61482 | 306719 | 31327915 |
Drug ineffective | 217.88 | 10.34 | 279 | 62431 | 395294 | 31239340 |
General physical health deterioration | 126.38 | 10.34 | 501 | 62209 | 112934 | 31521700 |
Dehydration | 106.35 | 10.34 | 492 | 62218 | 118619 | 31516015 |
Decreased appetite | 89.24 | 10.34 | 563 | 62147 | 152654 | 31481980 |
Pyrexia | 89.22 | 10.34 | 955 | 61755 | 302885 | 31331749 |
Drug abuse | 85.99 | 10.34 | 33 | 62677 | 87725 | 31546909 |
Product dose omission issue | 78.05 | 10.34 | 57 | 62653 | 105529 | 31529105 |
Dystonia | 73.77 | 10.34 | 96 | 62614 | 10129 | 31624505 |
Neutropenic sepsis | 72.39 | 10.34 | 105 | 62605 | 12274 | 31622360 |
Constipation | 72.38 | 10.34 | 456 | 62254 | 123535 | 31511099 |
Impaired gastric emptying | 71.75 | 10.34 | 56 | 62654 | 3188 | 31631446 |
Serotonin syndrome | 66.35 | 10.34 | 127 | 62583 | 18646 | 31615988 |
Aplastic anaemia | 64.21 | 10.34 | 85 | 62625 | 9118 | 31625516 |
Neutropenia | 57.44 | 10.34 | 474 | 62236 | 139890 | 31494744 |
Drug intolerance | 55.39 | 10.34 | 17 | 62693 | 52016 | 31582618 |
Psoriasis | 52.06 | 10.34 | 14 | 62696 | 46705 | 31587929 |
Malignant neoplasm progression | 50.77 | 10.34 | 298 | 62412 | 78700 | 31555934 |
Rheumatoid arthritis | 48.46 | 10.34 | 17 | 62693 | 47792 | 31586842 |
Thrombocytopenia | 47.08 | 10.34 | 460 | 62250 | 142287 | 31492347 |
Therapeutic product effect incomplete | 47.00 | 10.34 | 14 | 62696 | 43682 | 31590952 |
Completed suicide | 46.56 | 10.34 | 68 | 62642 | 91446 | 31543188 |
Pneumonitis | 43.86 | 10.34 | 147 | 62563 | 30505 | 31604129 |
Meconium abnormal | 40.25 | 10.34 | 12 | 62698 | 67 | 31634567 |
Peripheral swelling | 40.14 | 10.34 | 45 | 62665 | 67820 | 31566814 |
Therapeutic product effect decreased | 38.13 | 10.34 | 8 | 62702 | 31614 | 31603020 |
Off label use | 37.47 | 10.34 | 474 | 62236 | 346800 | 31287834 |
Death | 37.12 | 10.34 | 497 | 62213 | 360072 | 31274562 |
Hypokalaemia | 36.96 | 10.34 | 206 | 62504 | 53368 | 31581266 |
Alveolar lung disease | 36.64 | 10.34 | 17 | 62693 | 366 | 31634268 |
Abdominal pain | 35.55 | 10.34 | 443 | 62267 | 145509 | 31489125 |
Treatment failure | 34.25 | 10.34 | 19 | 62691 | 40773 | 31593861 |
Mucosal inflammation | 34.25 | 10.34 | 147 | 62563 | 34280 | 31600354 |
Arthralgia | 33.97 | 10.34 | 169 | 62541 | 151255 | 31483379 |
Genital erythema | 33.51 | 10.34 | 13 | 62697 | 176 | 31634458 |
Pulmonary interstitial emphysema syndrome | 33.20 | 10.34 | 17 | 62693 | 457 | 31634177 |
Sepsis | 32.76 | 10.34 | 451 | 62259 | 151478 | 31483156 |
Neuroleptic malignant syndrome | 32.68 | 10.34 | 90 | 62620 | 16779 | 31617855 |
Oesophagitis | 32.19 | 10.34 | 74 | 62636 | 12342 | 31622292 |
Foetal exposure during pregnancy | 30.78 | 10.34 | 161 | 62549 | 40715 | 31593919 |
Hiccups | 30.59 | 10.34 | 61 | 62649 | 9226 | 31625408 |
Hyponatraemia | 30.55 | 10.34 | 250 | 62460 | 73549 | 31561085 |
Pneumonia | 29.62 | 10.34 | 870 | 61840 | 334442 | 31300192 |
Hypophagia | 29.16 | 10.34 | 103 | 62607 | 21939 | 31612695 |
Diarrhoea | 29.16 | 10.34 | 907 | 61803 | 351502 | 31283132 |
Mesothelioma | 29.06 | 10.34 | 15 | 62695 | 410 | 31634224 |
Blood pressure fluctuation | 29.01 | 10.34 | 5 | 62705 | 22731 | 31611903 |
Toxic epidermal necrolysis | 28.25 | 10.34 | 94 | 62616 | 19430 | 31615204 |
Weight increased | 28.15 | 10.34 | 78 | 62632 | 82869 | 31551765 |
Laparotomy | 27.97 | 10.34 | 13 | 62697 | 281 | 31634353 |
Premature baby | 27.96 | 10.34 | 89 | 62621 | 17977 | 31616657 |
Anaemia | 27.78 | 10.34 | 584 | 62126 | 212938 | 31421696 |
Necrotising enterocolitis neonatal | 27.28 | 10.34 | 12 | 62698 | 227 | 31634407 |
Extrapyramidal disorder | 27.08 | 10.34 | 67 | 62643 | 11711 | 31622923 |
Joint swelling | 26.87 | 10.34 | 40 | 62670 | 53391 | 31581243 |
Toxicity to various agents | 26.75 | 10.34 | 230 | 62480 | 181257 | 31453377 |
Ileus | 26.53 | 10.34 | 78 | 62632 | 15091 | 31619543 |
Rash maculo-papular | 26.49 | 10.34 | 111 | 62599 | 25608 | 31609026 |
Malnutrition | 26.03 | 10.34 | 65 | 62645 | 11428 | 31623206 |
Condition aggravated | 25.92 | 10.34 | 204 | 62506 | 163805 | 31470829 |
Long QT syndrome | 25.09 | 10.34 | 27 | 62683 | 2329 | 31632305 |
Leukopenia | 24.52 | 10.34 | 197 | 62513 | 57631 | 31577003 |
Drug resistance | 24.35 | 10.34 | 8 | 62702 | 23445 | 31611189 |
Hepatic failure | 24.07 | 10.34 | 128 | 62582 | 32574 | 31602060 |
Haematopoietic stem cell mobilisation | 23.98 | 10.34 | 10 | 62700 | 165 | 31634469 |
Intentional product misuse | 23.73 | 10.34 | 24 | 62686 | 37927 | 31596707 |
Pleural effusion | 23.47 | 10.34 | 239 | 62471 | 74681 | 31559953 |
Hyperthermia malignant | 23.38 | 10.34 | 24 | 62686 | 1960 | 31632674 |
Asthma | 23.33 | 10.34 | 30 | 62680 | 42581 | 31592053 |
Intentional overdose | 22.80 | 10.34 | 29 | 62681 | 41360 | 31593274 |
Gastrointestinal hypermotility | 22.55 | 10.34 | 9 | 62701 | 132 | 31634502 |
Electrocardiogram QT prolonged | 22.28 | 10.34 | 140 | 62570 | 37847 | 31596787 |
Psoriatic arthropathy | 22.06 | 10.34 | 6 | 62704 | 19877 | 31614757 |
Intentional product use issue | 21.96 | 10.34 | 40 | 62670 | 49307 | 31585327 |
Impetigo | 21.83 | 10.34 | 17 | 62693 | 964 | 31633670 |
Vascular access site occlusion | 21.66 | 10.34 | 7 | 62703 | 53 | 31634581 |
Congenital pneumonia | 21.64 | 10.34 | 8 | 62702 | 94 | 31634540 |
Pseudomonal sepsis | 21.50 | 10.34 | 29 | 62681 | 3167 | 31631467 |
Enteritis | 21.45 | 10.34 | 45 | 62665 | 7054 | 31627580 |
Cytokine release syndrome | 21.36 | 10.34 | 77 | 62633 | 16565 | 31618069 |
Toxic encephalopathy | 21.20 | 10.34 | 36 | 62674 | 4814 | 31629820 |
Cardiac failure congestive | 21.17 | 10.34 | 83 | 62627 | 79304 | 31555330 |
Conjunctival irritation | 21.13 | 10.34 | 8 | 62702 | 101 | 31634533 |
Product use issue | 21.07 | 10.34 | 51 | 62659 | 56708 | 31577926 |
Colitis | 20.57 | 10.34 | 126 | 62584 | 33761 | 31600873 |
Dysphagia | 20.52 | 10.34 | 189 | 62521 | 57487 | 31577147 |
Urticaria | 20.33 | 10.34 | 53 | 62657 | 57464 | 31577170 |
Vocal cord inflammation | 20.31 | 10.34 | 7 | 62703 | 66 | 31634568 |
Delirium | 20.30 | 10.34 | 146 | 62564 | 41275 | 31593359 |
Heart sounds abnormal | 19.87 | 10.34 | 15 | 62695 | 812 | 31633822 |
Post concussion syndrome | 19.76 | 10.34 | 8 | 62702 | 122 | 31634512 |
Lymphoid tissue hypoplasia | 19.52 | 10.34 | 9 | 62701 | 191 | 31634443 |
Thymus hypoplasia | 19.52 | 10.34 | 9 | 62701 | 191 | 31634443 |
Talipes | 19.39 | 10.34 | 21 | 62689 | 1825 | 31632809 |
Erectile dysfunction | 19.21 | 10.34 | 7 | 62703 | 19228 | 31615406 |
Hepatocellular injury | 19.17 | 10.34 | 89 | 62621 | 21455 | 31613179 |
Arthropathy | 19.06 | 10.34 | 12 | 62698 | 24039 | 31610595 |
Feeling abnormal | 19.04 | 10.34 | 54 | 62656 | 56948 | 31577686 |
Wheezing | 19.02 | 10.34 | 26 | 62684 | 35960 | 31598674 |
Wrong technique in product usage process | 18.75 | 10.34 | 23 | 62687 | 33320 | 31601314 |
Heart rate decreased | 18.69 | 10.34 | 17 | 62693 | 28249 | 31606385 |
Electrocardiogram QT shortened | 18.50 | 10.34 | 8 | 62702 | 145 | 31634489 |
Stress cardiomyopathy | 18.17 | 10.34 | 20 | 62690 | 1770 | 31632864 |
Jaundice | 18.00 | 10.34 | 112 | 62598 | 30175 | 31604459 |
Superior vena cava occlusion | 17.83 | 10.34 | 7 | 62703 | 98 | 31634536 |
Tardive dyskinesia | 17.69 | 10.34 | 36 | 62674 | 5523 | 31629111 |
Myocardial infarction | 17.50 | 10.34 | 142 | 62568 | 113312 | 31521322 |
Non-small cell lung cancer | 17.31 | 10.34 | 30 | 62680 | 4079 | 31630555 |
Laryngeal cancer metastatic | 17.19 | 10.34 | 6 | 62704 | 59 | 31634575 |
Lower respiratory tract infection | 17.14 | 10.34 | 105 | 62605 | 28132 | 31606502 |
Device dislocation | 17.05 | 10.34 | 34 | 62676 | 5142 | 31629492 |
Failure to thrive | 16.96 | 10.34 | 44 | 62666 | 7918 | 31626716 |
Hospitalisation | 16.77 | 10.34 | 47 | 62663 | 49760 | 31584874 |
Pulmonary embolism | 16.61 | 10.34 | 240 | 62470 | 81406 | 31553228 |
Cytokine storm | 16.36 | 10.34 | 12 | 62698 | 622 | 31634012 |
Hyperbilirubinaemia | 16.24 | 10.34 | 68 | 62642 | 15682 | 31618952 |
Septic shock | 16.15 | 10.34 | 201 | 62509 | 65957 | 31568677 |
Chemotherapeutic drug level increased | 16.04 | 10.34 | 8 | 62702 | 203 | 31634431 |
Ileus paralytic | 16.01 | 10.34 | 34 | 62676 | 5374 | 31629260 |
Chills | 15.90 | 10.34 | 220 | 62490 | 73930 | 31560704 |
Suicide attempt | 15.86 | 10.34 | 31 | 62679 | 37217 | 31597417 |
Spleen congestion | 15.82 | 10.34 | 9 | 62701 | 300 | 31634334 |
Blood alkaline phosphatase increased | 15.71 | 10.34 | 106 | 62604 | 29347 | 31605287 |
Bacterial tracheitis | 15.68 | 10.34 | 3 | 62707 | 0 | 31634634 |
Tumour lysis syndrome | 15.53 | 10.34 | 66 | 62644 | 15319 | 31619315 |
Subileus | 15.53 | 10.34 | 24 | 62686 | 2966 | 31631668 |
Disturbance in attention | 15.45 | 10.34 | 13 | 62697 | 22437 | 31612197 |
Diffuse alveolar damage | 15.44 | 10.34 | 20 | 62690 | 2099 | 31632535 |
Musculoskeletal stiffness | 15.44 | 10.34 | 37 | 62673 | 41288 | 31593346 |
Gait disturbance | 15.41 | 10.34 | 90 | 62620 | 77405 | 31557229 |
Eczema asteatotic | 15.16 | 10.34 | 8 | 62702 | 229 | 31634405 |
Abdominal compartment syndrome | 15.15 | 10.34 | 13 | 62697 | 846 | 31633788 |
Gastrointestinal motility disorder | 15.14 | 10.34 | 21 | 62689 | 2355 | 31632279 |
Synovitis | 15.03 | 10.34 | 3 | 62707 | 12280 | 31622354 |
Neutrophil count decreased | 15.00 | 10.34 | 149 | 62561 | 46245 | 31588389 |
Tumour pain | 14.89 | 10.34 | 14 | 62696 | 1027 | 31633607 |
Ascites | 14.89 | 10.34 | 135 | 62575 | 40878 | 31593756 |
Fall | 14.82 | 10.34 | 269 | 62441 | 185820 | 31448814 |
Acute abdomen | 14.72 | 10.34 | 18 | 62692 | 1783 | 31632851 |
Injection site pain | 14.60 | 10.34 | 29 | 62681 | 34605 | 31600029 |
Blood creatine phosphokinase increased | 14.58 | 10.34 | 39 | 62671 | 41935 | 31592699 |
Loss of personal independence in daily activities | 14.39 | 10.34 | 21 | 62689 | 28267 | 31606367 |
Stress | 14.24 | 10.34 | 17 | 62693 | 24924 | 31609710 |
Seborrhoeic dermatitis | 14.19 | 10.34 | 16 | 62694 | 1454 | 31633180 |
Hypoalbuminaemia | 14.13 | 10.34 | 51 | 62659 | 10977 | 31623657 |
Dyschezia | 14.07 | 10.34 | 15 | 62695 | 1280 | 31633354 |
Blood pressure increased | 14.02 | 10.34 | 96 | 62614 | 79537 | 31555097 |
Platelet count decreased | 13.98 | 10.34 | 301 | 62409 | 110134 | 31524500 |
Neutropenic infection | 13.79 | 10.34 | 15 | 62695 | 1310 | 31633324 |
Symmetrical drug-related intertriginous and flexural exanthema | 13.76 | 10.34 | 8 | 62702 | 278 | 31634356 |
Phaeochromocytoma crisis | 13.66 | 10.34 | 5 | 62705 | 57 | 31634577 |
Bladder cancer | 13.66 | 10.34 | 6 | 62704 | 14719 | 31619915 |
Renal vasculitis | 13.57 | 10.34 | 7 | 62703 | 191 | 31634443 |
Product use in unapproved indication | 13.57 | 10.34 | 128 | 62582 | 99043 | 31535591 |
Swelling | 13.52 | 10.34 | 34 | 62676 | 37324 | 31597310 |
Diabetic gastroparesis | 13.52 | 10.34 | 6 | 62704 | 116 | 31634518 |
Immune-mediated hepatitis | 13.52 | 10.34 | 17 | 62693 | 1733 | 31632901 |
Dyskinesia | 13.49 | 10.34 | 79 | 62631 | 20831 | 31613803 |
Performance status decreased | 13.41 | 10.34 | 26 | 62684 | 3852 | 31630782 |
Cachexia | 13.30 | 10.34 | 36 | 62674 | 6643 | 31627991 |
Maternal drugs affecting foetus | 13.29 | 10.34 | 26 | 62684 | 3877 | 31630757 |
Headache | 13.24 | 10.34 | 270 | 62440 | 183382 | 31451252 |
Pulmonary sepsis | 13.14 | 10.34 | 18 | 62692 | 1994 | 31632640 |
Retching | 13.07 | 10.34 | 34 | 62676 | 6127 | 31628507 |
Body temperature increased | 13.00 | 10.34 | 62 | 62648 | 15111 | 31619523 |
Blood bilirubin increased | 12.93 | 10.34 | 116 | 62594 | 35020 | 31599614 |
Therapy non-responder | 12.85 | 10.34 | 30 | 62680 | 33781 | 31600853 |
Device related infection | 12.82 | 10.34 | 65 | 62645 | 16234 | 31618400 |
Venous angioma of brain | 12.65 | 10.34 | 4 | 62706 | 28 | 31634606 |
Klebsiella bacteraemia | 12.45 | 10.34 | 14 | 62696 | 1268 | 31633366 |
Restlessness | 12.42 | 10.34 | 84 | 62626 | 23277 | 31611357 |
Acute kidney injury | 12.40 | 10.34 | 674 | 62036 | 279040 | 31355594 |
Blood aluminium increased | 12.40 | 10.34 | 3 | 62707 | 6 | 31634628 |
COVID-19 | 12.37 | 10.34 | 61 | 62649 | 54760 | 31579874 |
Pericardial effusion | 12.14 | 10.34 | 81 | 62629 | 22342 | 31612292 |
Intestinal ischaemia | 12.10 | 10.34 | 36 | 62674 | 7009 | 31627625 |
Cholangitis | 12.04 | 10.34 | 39 | 62671 | 7947 | 31626687 |
Ventricular septal defect | 11.93 | 10.34 | 24 | 62686 | 3653 | 31630981 |
Underdose | 11.91 | 10.34 | 5 | 62705 | 12602 | 31622032 |
Sopor | 11.89 | 10.34 | 4 | 62706 | 11548 | 31623086 |
Hygroma colli | 11.87 | 10.34 | 4 | 62706 | 35 | 31634599 |
Systemic infection | 11.77 | 10.34 | 23 | 62687 | 3426 | 31631208 |
Aortitis | 11.73 | 10.34 | 8 | 62702 | 369 | 31634265 |
Prostate cancer | 11.56 | 10.34 | 37 | 62673 | 37564 | 31597070 |
Product quality issue | 11.50 | 10.34 | 9 | 62701 | 16102 | 31618532 |
Disseminated aspergillosis | 11.46 | 10.34 | 9 | 62701 | 517 | 31634117 |
Disease recurrence | 11.44 | 10.34 | 12 | 62698 | 18649 | 31615985 |
Scan abnormal | 11.40 | 10.34 | 4 | 62706 | 40 | 31634594 |
Herpes zoster reactivation | 11.33 | 10.34 | 7 | 62703 | 272 | 31634362 |
Tumour perforation | 11.22 | 10.34 | 7 | 62703 | 277 | 31634357 |
Kounis syndrome | 11.21 | 10.34 | 17 | 62693 | 2067 | 31632567 |
Spinal cord injury thoracic | 11.21 | 10.34 | 5 | 62705 | 98 | 31634536 |
Restrictive cardiomyopathy | 11.02 | 10.34 | 10 | 62700 | 701 | 31633933 |
Clostridium difficile colitis | 11.02 | 10.34 | 56 | 62654 | 14000 | 31620634 |
Gastrointestinal malformation | 10.98 | 10.34 | 4 | 62706 | 45 | 31634589 |
Eastern Cooperative Oncology Group performance status worsened | 10.96 | 10.34 | 11 | 62699 | 875 | 31633759 |
Cholestasis | 10.94 | 10.34 | 86 | 62624 | 24989 | 31609645 |
Type III immune complex mediated reaction | 10.93 | 10.34 | 7 | 62703 | 290 | 31634344 |
Psychotic disorder | 10.90 | 10.34 | 17 | 62693 | 22276 | 31612358 |
Obstruction gastric | 10.89 | 10.34 | 11 | 62699 | 881 | 31633753 |
Oesophageal hypomotility | 10.88 | 10.34 | 3 | 62707 | 12 | 31634622 |
Congenital nasal septum deviation | 10.88 | 10.34 | 3 | 62707 | 12 | 31634622 |
Lenticulostriatal vasculopathy | 10.88 | 10.34 | 3 | 62707 | 12 | 31634622 |
Aphthous ulcer | 10.87 | 10.34 | 26 | 62684 | 4448 | 31630186 |
Gastritis | 10.80 | 10.34 | 73 | 62637 | 20219 | 31614415 |
Nasopharyngitis | 10.76 | 10.34 | 77 | 62633 | 63168 | 31571466 |
Angina pectoris | 10.71 | 10.34 | 27 | 62683 | 29614 | 31605020 |
Skeletal dysplasia | 10.68 | 10.34 | 5 | 62705 | 110 | 31634524 |
Road traffic accident | 10.65 | 10.34 | 10 | 62700 | 16371 | 31618263 |
Hypoaesthesia | 10.64 | 10.34 | 66 | 62644 | 55956 | 31578678 |
Buttock injury | 10.60 | 10.34 | 4 | 62706 | 50 | 31634584 |
Aggression | 10.58 | 10.34 | 38 | 62672 | 37253 | 31597381 |
Gastroenteritis | 10.51 | 10.34 | 53 | 62657 | 13209 | 31621425 |
Calcium ionised increased | 10.51 | 10.34 | 3 | 62707 | 14 | 31634620 |
Neutropenic colitis | 10.49 | 10.34 | 19 | 62691 | 2673 | 31631961 |
Hepatitis fulminant | 10.46 | 10.34 | 23 | 62687 | 3723 | 31630911 |
Cardiac disorder | 10.44 | 10.34 | 41 | 62669 | 39173 | 31595461 |
Diabetes mellitus | 10.40 | 10.34 | 46 | 62664 | 42510 | 31592124 |
Hypothermia | 10.37 | 10.34 | 3 | 62707 | 9541 | 31625093 |
Bacteraemia | 10.34 | 10.34 | 65 | 62645 | 17569 | 31617065 |
MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
---|---|---|---|---|---|---|
Febrile neutropenia | 727.79 | 9.91 | 1401 | 141819 | 202917 | 70582307 |
Vomiting | 663.79 | 9.91 | 2655 | 140565 | 590456 | 70194768 |
Nausea | 560.84 | 9.91 | 3273 | 139947 | 848815 | 69936409 |
Drug ineffective | 477.92 | 9.91 | 727 | 142493 | 939025 | 69846199 |
Rheumatoid arthritis | 416.90 | 9.91 | 50 | 143170 | 291755 | 70493469 |
Drug intolerance | 262.72 | 9.91 | 66 | 143154 | 225621 | 70559603 |
Joint swelling | 248.70 | 9.91 | 100 | 143120 | 253111 | 70532113 |
Synovitis | 218.54 | 9.91 | 10 | 143210 | 129218 | 70656006 |
Neutropenic sepsis | 213.31 | 9.91 | 257 | 142963 | 24573 | 70760651 |
Pyrexia | 210.65 | 9.91 | 2007 | 141213 | 604945 | 70180279 |
Therapeutic product effect decreased | 207.84 | 9.91 | 23 | 143197 | 142995 | 70642229 |
General physical health deterioration | 205.40 | 9.91 | 982 | 142238 | 235049 | 70550175 |
Dystonia | 199.53 | 9.91 | 222 | 142998 | 19484 | 70765740 |
Dehydration | 196.86 | 9.91 | 941 | 142279 | 225201 | 70560023 |
Hypokalaemia | 189.95 | 9.91 | 640 | 142580 | 130548 | 70654676 |
Arthropathy | 184.29 | 9.91 | 39 | 143181 | 150018 | 70635206 |
Constipation | 179.73 | 9.91 | 993 | 142227 | 251445 | 70533779 |
Decreased appetite | 179.17 | 9.91 | 1140 | 142080 | 303640 | 70481584 |
Arthralgia | 178.84 | 9.91 | 478 | 142742 | 502912 | 70282312 |
Serotonin syndrome | 165.94 | 9.91 | 302 | 142918 | 41812 | 70743412 |
Contraindicated product administered | 157.28 | 9.91 | 39 | 143181 | 134573 | 70650651 |
Hand deformity | 155.62 | 9.91 | 4 | 143216 | 86478 | 70698746 |
Neutropenia | 153.62 | 9.91 | 966 | 142254 | 256190 | 70529034 |
Completed suicide | 144.72 | 9.91 | 147 | 143073 | 226988 | 70558236 |
Weight increased | 143.15 | 9.91 | 167 | 143053 | 242164 | 70543060 |
Product dose omission issue | 134.87 | 9.91 | 144 | 143076 | 217324 | 70567900 |
Mucosal inflammation | 133.79 | 9.91 | 369 | 142851 | 67481 | 70717743 |
Thrombocytopenia | 131.62 | 9.91 | 880 | 142340 | 238230 | 70546994 |
Swelling | 129.49 | 9.91 | 114 | 143106 | 188425 | 70596799 |
Diarrhoea | 125.52 | 9.91 | 2248 | 140972 | 781093 | 70004131 |
Abdominal pain | 124.58 | 9.91 | 1144 | 142076 | 340983 | 70444241 |
Systemic lupus erythematosus | 124.04 | 9.91 | 27 | 143193 | 101875 | 70683349 |
Impaired gastric emptying | 121.44 | 9.91 | 121 | 143099 | 9345 | 70775879 |
Malignant neoplasm progression | 120.99 | 9.91 | 527 | 142693 | 121212 | 70664012 |
Hyponatraemia | 116.67 | 9.91 | 634 | 142586 | 159453 | 70625771 |
Aplastic anaemia | 113.56 | 9.91 | 154 | 143066 | 16562 | 70768662 |
Psoriasis | 110.26 | 9.91 | 31 | 143189 | 98402 | 70686822 |
Peripheral swelling | 107.35 | 9.91 | 196 | 143024 | 236367 | 70548857 |
Sinusitis | 104.92 | 9.91 | 112 | 143108 | 169083 | 70616141 |
Injection site pain | 97.85 | 9.91 | 58 | 143162 | 117561 | 70667663 |
Glossodynia | 97.31 | 9.91 | 27 | 143193 | 86460 | 70698764 |
Nasopharyngitis | 94.79 | 9.91 | 191 | 143029 | 222015 | 70563209 |
Toxic epidermal necrolysis | 94.27 | 9.91 | 231 | 142989 | 39326 | 70745898 |
Torsade de pointes | 92.70 | 9.91 | 146 | 143074 | 17970 | 70767254 |
Treatment failure | 92.09 | 9.91 | 93 | 143127 | 144049 | 70641175 |
Anaemia | 89.58 | 9.91 | 1224 | 141996 | 402199 | 70383025 |
Musculoskeletal stiffness | 89.18 | 9.91 | 100 | 143120 | 147660 | 70637564 |
Pulmonary embolism | 88.93 | 9.91 | 579 | 142641 | 155288 | 70629936 |
Phaeochromocytoma crisis | 86.16 | 9.91 | 30 | 143190 | 286 | 70784938 |
Pericarditis | 85.47 | 9.91 | 32 | 143188 | 84673 | 70700551 |
Therapeutic product effect incomplete | 85.32 | 9.91 | 70 | 143150 | 119812 | 70665412 |
Abdominal discomfort | 85.31 | 9.91 | 192 | 143028 | 214466 | 70570758 |
Hypomagnesaemia | 84.65 | 9.91 | 226 | 142994 | 40538 | 70744686 |
Product use issue | 83.48 | 9.91 | 147 | 143073 | 179790 | 70605434 |
Psoriatic arthropathy | 83.35 | 9.91 | 15 | 143205 | 64756 | 70720468 |
Extrapyramidal disorder | 78.20 | 9.91 | 146 | 143074 | 20604 | 70764620 |
Wound | 77.56 | 9.91 | 52 | 143168 | 98680 | 70686544 |
Hepatic enzyme increased | 76.74 | 9.91 | 124 | 143096 | 156866 | 70628358 |
Sepsis | 76.28 | 9.91 | 792 | 142428 | 243753 | 70541471 |
Electrocardiogram QT prolonged | 74.31 | 9.91 | 350 | 142870 | 83167 | 70702057 |
Duodenal ulcer perforation | 72.28 | 9.91 | 9 | 143211 | 51103 | 70734121 |
Atelectasis | 69.93 | 9.91 | 170 | 143050 | 28792 | 70756432 |
Ileus | 69.24 | 9.91 | 152 | 143068 | 24085 | 70761139 |
Discomfort | 67.36 | 9.91 | 68 | 143152 | 105368 | 70679856 |
Helicobacter infection | 67.21 | 9.91 | 15 | 143205 | 55641 | 70729583 |
Blood pressure fluctuation | 67.17 | 9.91 | 18 | 143202 | 58994 | 70726230 |
Muscle injury | 64.98 | 9.91 | 3 | 143217 | 38491 | 70746733 |
Leukopenia | 64.55 | 9.91 | 402 | 142818 | 106158 | 70679066 |
Subileus | 60.12 | 9.91 | 63 | 143157 | 5164 | 70780060 |
Sleep disorder due to general medical condition, insomnia type | 59.63 | 9.91 | 3 | 143217 | 35729 | 70749495 |
Arthritis | 59.45 | 9.91 | 66 | 143154 | 97914 | 70687310 |
Colitis | 59.40 | 9.91 | 271 | 142949 | 63543 | 70721681 |
Condition aggravated | 59.15 | 9.91 | 565 | 142655 | 427070 | 70358154 |
Computerised tomogram thorax abnormal | 58.59 | 9.91 | 42 | 143178 | 2056 | 70783168 |
Neutrophil count decreased | 58.19 | 9.91 | 327 | 142893 | 83229 | 70701995 |
Asthma | 57.54 | 9.91 | 97 | 143123 | 120696 | 70664528 |
Neovascularisation | 57.04 | 9.91 | 33 | 143187 | 1112 | 70784112 |
Pneumonitis | 57.01 | 9.91 | 240 | 142980 | 54357 | 70730867 |
Parkinsonism | 56.71 | 9.91 | 107 | 143113 | 15218 | 70770006 |
Pneumonia | 56.14 | 9.91 | 1588 | 141632 | 594644 | 70190580 |
Impaired healing | 55.99 | 9.91 | 41 | 143179 | 74333 | 70710891 |
Oesophagitis | 55.80 | 9.91 | 134 | 143086 | 22518 | 70762706 |
Rash maculo-papular | 55.78 | 9.91 | 226 | 142994 | 50319 | 70734905 |
Pain | 55.71 | 9.91 | 914 | 142306 | 627902 | 70157322 |
Fall | 55.54 | 9.91 | 601 | 142619 | 443495 | 70341729 |
Phaeochromocytoma | 53.92 | 9.91 | 26 | 143194 | 599 | 70784625 |
Neuroleptic malignant syndrome | 53.80 | 9.91 | 144 | 143076 | 25863 | 70759361 |
Tardive dyskinesia | 53.56 | 9.91 | 82 | 143138 | 9847 | 70775377 |
Acute kidney injury | 53 | 9.91 | 1293 | 141927 | 473331 | 70311893 |
Cholecystitis chronic | 51.38 | 9.91 | 78 | 143142 | 9298 | 70775926 |
Hepatocellular injury | 50.79 | 9.91 | 206 | 143014 | 45885 | 70739339 |
Injection site bruising | 50.72 | 9.91 | 8 | 143212 | 38024 | 70747200 |
Intentional product use issue | 49.73 | 9.91 | 105 | 143115 | 120037 | 70665187 |
Contusion | 49.64 | 9.91 | 116 | 143104 | 127920 | 70657304 |
Hiccups | 49.17 | 9.91 | 75 | 143145 | 8977 | 70776247 |
Drug abuse | 49.01 | 9.91 | 144 | 143076 | 147112 | 70638112 |
Injection site erythema | 48.94 | 9.91 | 45 | 143175 | 72879 | 70712345 |
Blood pressure increased | 48.89 | 9.91 | 205 | 143015 | 188312 | 70596912 |
Heart rate decreased | 48.24 | 9.91 | 33 | 143187 | 61982 | 70723242 |
Pleural effusion | 47.57 | 9.91 | 443 | 142777 | 132421 | 70652803 |
Red blood cell sedimentation rate increased | 47.50 | 9.91 | 10 | 143210 | 38632 | 70746592 |
Therapeutic response decreased | 46.96 | 9.91 | 30 | 143190 | 58423 | 70726801 |
Cytokine release syndrome | 46.38 | 9.91 | 138 | 143082 | 26329 | 70758895 |
Restlessness | 46.19 | 9.91 | 188 | 143032 | 41940 | 70743284 |
Oculogyric crisis | 45.20 | 9.91 | 40 | 143180 | 2658 | 70782566 |
Injection site swelling | 44.04 | 9.91 | 16 | 143204 | 43141 | 70742083 |
Knee arthroplasty | 44.01 | 9.91 | 8 | 143212 | 34293 | 70750931 |
Osteoarthritis | 43.83 | 9.91 | 51 | 143169 | 74096 | 70711128 |
Peripheral circulatory failure | 43.51 | 9.91 | 27 | 143193 | 1036 | 70784188 |
Gastritis | 43.47 | 9.91 | 192 | 143028 | 44399 | 70740825 |
C-reactive protein abnormal | 43.47 | 9.91 | 12 | 143208 | 38567 | 70746657 |
Septic shock | 43.09 | 9.91 | 380 | 142840 | 111878 | 70673346 |
Wrong technique in product usage process | 43.09 | 9.91 | 45 | 143175 | 68653 | 70716571 |
Malnutrition | 42.54 | 9.91 | 113 | 143107 | 20204 | 70765020 |
Long QT syndrome | 42.29 | 9.91 | 53 | 143167 | 5274 | 70779950 |
Pain in extremity | 42.19 | 9.91 | 441 | 142779 | 327641 | 70457583 |
Hypophagia | 41.29 | 9.91 | 180 | 143040 | 41390 | 70743834 |
Urticaria | 41.23 | 9.91 | 179 | 143041 | 162870 | 70622354 |
Loss of personal independence in daily activities | 40.60 | 9.91 | 68 | 143152 | 84842 | 70700382 |
Irritable bowel syndrome | 39.63 | 9.91 | 27 | 143193 | 50823 | 70734401 |
Pancytopenia | 39.58 | 9.91 | 473 | 142747 | 150634 | 70634590 |
Injection site reaction | 39.49 | 9.91 | 26 | 143194 | 49826 | 70735398 |
Injection site pruritus | 39.23 | 9.91 | 15 | 143205 | 39195 | 70746029 |
Blood cholesterol increased | 38.66 | 9.91 | 44 | 143176 | 64560 | 70720664 |
Cholestasis | 38.54 | 9.91 | 195 | 143025 | 47677 | 70737547 |
Intentional overdose | 38.30 | 9.91 | 89 | 143131 | 98346 | 70686878 |
Folliculitis | 38.30 | 9.91 | 19 | 143201 | 42551 | 70742673 |
Dysphagia | 38.29 | 9.91 | 372 | 142848 | 112462 | 70672762 |
Neuropathy peripheral | 38.11 | 9.91 | 408 | 142812 | 126488 | 70658736 |
Haematemesis | 38.05 | 9.91 | 197 | 143023 | 48600 | 70736624 |
Toxicity to various agents | 37.67 | 9.91 | 544 | 142676 | 381628 | 70403596 |
Drug resistance | 37.57 | 9.91 | 15 | 143205 | 38175 | 70747049 |
Computerised tomogram thorax | 37.28 | 9.91 | 15 | 143205 | 220 | 70785004 |
Hepatic failure | 37.17 | 9.91 | 221 | 142999 | 57404 | 70727820 |
Aplasia | 36.49 | 9.91 | 58 | 143162 | 7193 | 70778031 |
Gastroenteritis | 36.39 | 9.91 | 142 | 143078 | 31071 | 70754153 |
Hypoxia | 34.29 | 9.91 | 313 | 142907 | 93031 | 70692193 |
Therapy non-responder | 33.72 | 9.91 | 65 | 143155 | 76850 | 70708374 |
Genital erythema | 33.63 | 9.91 | 14 | 143206 | 225 | 70784999 |
Pulmonary interstitial emphysema syndrome | 33.00 | 9.91 | 17 | 143203 | 453 | 70784771 |
Wheezing | 32.87 | 9.91 | 90 | 143130 | 94080 | 70691144 |
Hypersensitivity | 32.84 | 9.91 | 301 | 142919 | 229511 | 70555713 |
Electrolyte imbalance | 31.97 | 9.91 | 123 | 143097 | 26738 | 70758486 |
Stevens-Johnson syndrome | 31.57 | 9.91 | 150 | 143070 | 35757 | 70749467 |
Mixed liver injury | 31.47 | 9.91 | 50 | 143170 | 6199 | 70779025 |
Adverse drug reaction | 31.19 | 9.91 | 37 | 143183 | 53307 | 70731917 |
Small intestinal obstruction | 31.08 | 9.91 | 115 | 143105 | 24540 | 70760684 |
Ascites | 30.93 | 9.91 | 238 | 142982 | 67309 | 70717915 |
Suicide attempt | 30.84 | 9.91 | 72 | 143148 | 79438 | 70705786 |
Dyskinesia | 30.77 | 9.91 | 164 | 143056 | 40910 | 70744314 |
Gait disturbance | 30.72 | 9.91 | 233 | 142987 | 184873 | 70600351 |
Febrile bone marrow aplasia | 30.69 | 9.91 | 72 | 143148 | 11919 | 70773305 |
Renal ischaemia | 30.62 | 9.91 | 22 | 143198 | 1081 | 70784143 |
Alveolar lung disease | 30.32 | 9.91 | 17 | 143203 | 539 | 70784685 |
Headache | 30.23 | 9.91 | 917 | 142303 | 579488 | 70205736 |
Foetal death | 30.16 | 9.91 | 49 | 143171 | 6190 | 70779034 |
Peritonitis | 29.68 | 9.91 | 118 | 143102 | 26041 | 70759183 |
Off label use | 29.55 | 9.91 | 1214 | 142006 | 741846 | 70043378 |
Blood magnesium decreased | 29.52 | 9.91 | 81 | 143139 | 14760 | 70770464 |
Fibromyalgia | 29.31 | 9.91 | 32 | 143188 | 47842 | 70737382 |
Gamma-glutamyltransferase increased | 29.30 | 9.91 | 189 | 143031 | 50496 | 70734728 |
Joint injury | 29.20 | 9.91 | 9 | 143211 | 26923 | 70758301 |
Device expulsion | 28.95 | 9.91 | 5 | 143215 | 22241 | 70762983 |
Duodenal stenosis | 28.91 | 9.91 | 18 | 143202 | 695 | 70784529 |
Platelet count decreased | 28.83 | 9.91 | 513 | 142707 | 177709 | 70607515 |
Enterocolitis | 28.71 | 9.91 | 74 | 143146 | 12992 | 70772232 |
PO2 increased | 28.61 | 9.91 | 24 | 143196 | 1483 | 70783741 |
Stress | 28.45 | 9.91 | 59 | 143161 | 67907 | 70717317 |
Akathisia | 28.45 | 9.91 | 71 | 143149 | 12222 | 70773002 |
Cholecystitis | 28.17 | 9.91 | 99 | 143121 | 20602 | 70764622 |
Mobility decreased | 27.95 | 9.91 | 110 | 143110 | 102889 | 70682335 |
PCO2 increased | 27.91 | 9.91 | 25 | 143195 | 1688 | 70783536 |
Ill-defined disorder | 27.91 | 9.91 | 42 | 143178 | 54699 | 70730525 |
Cardiac arrest | 27.62 | 9.91 | 465 | 142755 | 159369 | 70625855 |
COVID-19 | 27.40 | 9.91 | 115 | 143105 | 105642 | 70679582 |
Blood pressure systolic increased | 27.24 | 9.91 | 46 | 143174 | 57213 | 70728011 |
Cataract | 27.13 | 9.91 | 44 | 143176 | 55601 | 70729623 |
Abdominal pain upper | 27.10 | 9.91 | 545 | 142675 | 193057 | 70592167 |
Hypoaesthesia | 26.72 | 9.91 | 191 | 143029 | 153548 | 70631676 |
Abortion spontaneous | 26.71 | 9.91 | 10 | 143210 | 26469 | 70758755 |
Blood alkaline phosphatase increased | 26.68 | 9.91 | 206 | 143014 | 58315 | 70726909 |
Feeling abnormal | 26.62 | 9.91 | 173 | 143047 | 142146 | 70643078 |
Inappropriate schedule of product administration | 26.62 | 9.91 | 119 | 143101 | 107436 | 70677788 |
Ileus paralytic | 26.23 | 9.91 | 56 | 143164 | 8705 | 70776519 |
Disease progression | 26.06 | 9.91 | 453 | 142767 | 156219 | 70629005 |
Adverse event | 25.17 | 9.91 | 38 | 143182 | 49423 | 70735801 |
Tachycardia | 25.15 | 9.91 | 455 | 142765 | 158091 | 70627133 |
Acute abdomen | 24.92 | 9.91 | 30 | 143190 | 2864 | 70782360 |
Intestinal perforation | 24.72 | 9.91 | 80 | 143140 | 15964 | 70769260 |
Accidental exposure to product | 24.52 | 9.91 | 13 | 143207 | 28038 | 70757186 |
Infusion site streaking | 24.44 | 9.91 | 14 | 143206 | 463 | 70784761 |
Lymphoid tissue hypoplasia | 24.05 | 9.91 | 15 | 143205 | 581 | 70784643 |
Hypocalcaemia | 23.96 | 9.91 | 164 | 143056 | 44695 | 70740529 |
Encephalopathy | 23.79 | 9.91 | 209 | 143011 | 61452 | 70723772 |
Secondary adrenocortical insufficiency | 23.72 | 9.91 | 28 | 143192 | 2619 | 70782605 |
Pancreatitis | 23.45 | 9.91 | 211 | 143009 | 62457 | 70722767 |
Cancer pain | 23.18 | 9.91 | 38 | 143182 | 4836 | 70780388 |
Infusion related reaction | 23.18 | 9.91 | 271 | 142949 | 197263 | 70587961 |
Hyperprolactinaemia | 23.18 | 9.91 | 36 | 143184 | 4377 | 70780847 |
Tumour lysis syndrome | 23.16 | 9.91 | 95 | 143125 | 21265 | 70763959 |
Neutropenic colitis | 23.16 | 9.91 | 39 | 143181 | 5075 | 70780149 |
Hypoalbuminaemia | 23.11 | 9.91 | 88 | 143132 | 19034 | 70766190 |
Blood bilirubin increased | 23.09 | 9.91 | 203 | 143017 | 59698 | 70725526 |
Thymus hypoplasia | 23.09 | 9.91 | 15 | 143205 | 624 | 70784600 |
Injection site rash | 22.93 | 9.91 | 3 | 143217 | 16407 | 70768817 |
Carcinoid tumour of the stomach | 22.79 | 9.91 | 10 | 143210 | 184 | 70785040 |
Gelastic seizure | 22.58 | 9.91 | 5 | 143215 | 5 | 70785219 |
Deep vein thrombosis | 22.57 | 9.91 | 332 | 142888 | 110710 | 70674514 |
Urosepsis | 22.50 | 9.91 | 102 | 143118 | 23847 | 70761377 |
Blood pressure diastolic decreased | 22.45 | 9.91 | 12 | 143208 | 25768 | 70759456 |
Post concussion syndrome | 22.45 | 9.91 | 14 | 143206 | 542 | 70784682 |
Respiratory dyskinesia | 21.99 | 9.91 | 7 | 143213 | 49 | 70785175 |
Immune-mediated hepatitis | 21.93 | 9.91 | 28 | 143192 | 2838 | 70782386 |
Alopecia | 21.89 | 9.91 | 276 | 142944 | 198214 | 70587010 |
Non-small cell lung cancer | 21.87 | 9.91 | 43 | 143177 | 6304 | 70778920 |
Haematopoietic stem cell mobilisation | 21.67 | 9.91 | 10 | 143210 | 208 | 70785016 |
Diabetes insipidus | 21.65 | 9.91 | 36 | 143184 | 4635 | 70780589 |
Intentional product misuse | 21.59 | 9.91 | 85 | 143135 | 79510 | 70705714 |
Excessive eye blinking | 21.39 | 9.91 | 20 | 143200 | 1427 | 70783797 |
Cardiac failure congestive | 21.31 | 9.91 | 173 | 143047 | 135284 | 70649940 |
Left ventricular dysfunction | 21.18 | 9.91 | 82 | 143138 | 17875 | 70767349 |
Myocardial infarction | 21.11 | 9.91 | 233 | 142987 | 171412 | 70613812 |
Drug clearance decreased | 20.83 | 9.91 | 28 | 143192 | 2985 | 70782239 |
Hyponatraemic seizure | 20.72 | 9.91 | 13 | 143207 | 509 | 70784715 |
Jaundice | 20.46 | 9.91 | 172 | 143048 | 49936 | 70735288 |
Hypophosphataemia | 20.45 | 9.91 | 76 | 143144 | 16250 | 70768974 |
Mouth ulceration | 20.42 | 9.91 | 129 | 143091 | 34220 | 70751004 |
Blood bicarbonate decreased | 20.18 | 9.91 | 36 | 143184 | 4905 | 70780319 |
Palmar-plantar erythrodysaesthesia syndrome | 20.14 | 9.91 | 117 | 143103 | 30130 | 70755094 |
Eructation | 20.14 | 9.91 | 54 | 143166 | 9706 | 70775518 |
Throat irritation | 20.10 | 9.91 | 25 | 143195 | 35279 | 70749945 |
Diabetic gastroparesis | 19.92 | 9.91 | 10 | 143210 | 252 | 70784972 |
Illness | 19.74 | 9.91 | 21 | 143199 | 31770 | 70753454 |
Disseminated aspergillosis | 19.63 | 9.91 | 15 | 143205 | 810 | 70784414 |
Herpes zoster | 19.51 | 9.91 | 97 | 143123 | 85138 | 70700086 |
Onychalgia | 19.46 | 9.91 | 15 | 143205 | 821 | 70784403 |
Cystitis noninfective | 19.39 | 9.91 | 18 | 143202 | 1273 | 70783951 |
Influenza | 19.39 | 9.91 | 142 | 143078 | 113558 | 70671666 |
Injection site haemorrhage | 19.30 | 9.91 | 14 | 143206 | 25513 | 70759711 |
Systemic infection | 19.30 | 9.91 | 42 | 143178 | 6615 | 70778609 |
Vascular access site occlusion | 19.29 | 9.91 | 7 | 143213 | 76 | 70785148 |
Emotional distress | 19.29 | 9.91 | 135 | 143085 | 37053 | 70748171 |
Road traffic accident | 19.29 | 9.91 | 25 | 143195 | 34657 | 70750567 |
Conjunctival irritation | 19.25 | 9.91 | 8 | 143212 | 128 | 70785096 |
Urinary retention | 19.22 | 9.91 | 176 | 143044 | 52344 | 70732880 |
Nasal congestion | 19.21 | 9.91 | 68 | 143152 | 65604 | 70719620 |
Sopor | 19.03 | 9.91 | 21 | 143199 | 31246 | 70753978 |
Respiratory tract congestion | 18.96 | 9.91 | 6 | 143214 | 17647 | 70767577 |
Toxic encephalopathy | 18.94 | 9.91 | 55 | 143165 | 10351 | 70774873 |
Thymus disorder | 18.83 | 9.91 | 10 | 143210 | 284 | 70784940 |
Polydipsia | 18.77 | 9.91 | 39 | 143181 | 5949 | 70779275 |
Dyspepsia | 18.77 | 9.91 | 268 | 142952 | 88809 | 70696415 |
Pituitary tumour benign | 18.63 | 9.91 | 24 | 143196 | 2455 | 70782769 |
Enterochromaffin cell hyperplasia | 18.59 | 9.91 | 7 | 143213 | 85 | 70785139 |
Alveolitis | 18.52 | 9.91 | 30 | 143190 | 3781 | 70781443 |
Hepatitis fulminant | 18.49 | 9.91 | 41 | 143179 | 6540 | 70778684 |
Tumour pain | 18.48 | 9.91 | 22 | 143198 | 2076 | 70783148 |
Pseudomonal sepsis | 18.46 | 9.91 | 37 | 143183 | 5500 | 70779724 |
Bursitis | 18.44 | 9.91 | 16 | 143204 | 26657 | 70758567 |
Heart rate increased | 18.37 | 9.91 | 132 | 143088 | 106016 | 70679208 |
Multiple sclerosis relapse | 18.29 | 9.91 | 37 | 143183 | 42980 | 70742244 |
Aortic rupture | 18.29 | 9.91 | 9 | 143211 | 217 | 70785007 |
Cholangitis | 18.17 | 9.91 | 58 | 143162 | 11491 | 70773733 |
Multiple drug therapy | 18.12 | 9.91 | 27 | 143193 | 3165 | 70782059 |
Skin candida | 17.88 | 9.91 | 20 | 143200 | 1765 | 70783459 |
Cachexia | 17.71 | 9.91 | 52 | 143168 | 9848 | 70775376 |
Rash | 17.60 | 9.91 | 847 | 142373 | 509715 | 70275509 |
Opisthotonus | 17.56 | 9.91 | 13 | 143207 | 669 | 70784555 |
Intestinal ischaemia | 17.56 | 9.91 | 59 | 143161 | 12005 | 70773219 |
Respiratory syncytial virus infection | 17.49 | 9.91 | 44 | 143176 | 7611 | 70777613 |
Intentional self-injury | 17.41 | 9.91 | 23 | 143197 | 31627 | 70753597 |
Malignant polyp | 17.36 | 9.91 | 8 | 143212 | 166 | 70785058 |
Klebsiella bacteraemia | 17.34 | 9.91 | 24 | 143196 | 2630 | 70782594 |
Memory impairment | 17.12 | 9.91 | 113 | 143107 | 92528 | 70692696 |
Device issue | 17.12 | 9.91 | 14 | 143206 | 24011 | 70761213 |
Obstruction gastric | 17.07 | 9.91 | 18 | 143202 | 1486 | 70783738 |
Fluid retention | 17.00 | 9.91 | 68 | 143152 | 63317 | 70721907 |
Pruritus | 16.96 | 9.91 | 550 | 142670 | 345010 | 70440214 |
Insomnia | 16.84 | 9.91 | 324 | 142896 | 217482 | 70567742 |
Tumour perforation | 16.79 | 9.91 | 10 | 143210 | 356 | 70784868 |
Hypergastrinaemia | 16.72 | 9.91 | 8 | 143212 | 181 | 70785043 |
Failure to thrive | 16.69 | 9.91 | 54 | 143166 | 10775 | 70774449 |
Hospitalisation | 16.67 | 9.91 | 98 | 143122 | 82470 | 70702754 |
Hypochloraemia | 16.44 | 9.91 | 21 | 143199 | 2130 | 70783094 |
Tenosynovitis | 16.41 | 9.91 | 4 | 143216 | 13972 | 70771252 |
Irritability | 16.15 | 9.91 | 33 | 143187 | 38192 | 70747032 |
Nail infection | 16.13 | 9.91 | 21 | 143199 | 2170 | 70783054 |
Therapy cessation | 16.07 | 9.91 | 27 | 143193 | 33649 | 70751575 |
Transfusion | 16.06 | 9.91 | 78 | 143142 | 18758 | 70766466 |
Electrocardiogram T wave inversion | 16.04 | 9.91 | 33 | 143187 | 4998 | 70780226 |
Torticollis | 16.00 | 9.91 | 21 | 143199 | 2188 | 70783036 |
Burning sensation | 15.96 | 9.91 | 54 | 143166 | 52816 | 70732408 |
Confusional state | 15.84 | 9.91 | 714 | 142506 | 283684 | 70501540 |
Incorrect dose administered | 15.80 | 9.91 | 75 | 143145 | 66644 | 70718580 |
Non-cardiac chest pain | 15.79 | 9.91 | 47 | 143173 | 8968 | 70776256 |
Acute interstitial pneumonitis | 15.76 | 9.91 | 15 | 143205 | 1095 | 70784129 |
Pancreatic carcinoma metastatic | 15.71 | 9.91 | 28 | 143192 | 3812 | 70781412 |
Sudden death | 15.70 | 9.91 | 84 | 143136 | 20980 | 70764244 |
Grip strength decreased | 15.69 | 9.91 | 6 | 143214 | 15679 | 70769545 |
Blood pressure diastolic increased | 15.66 | 9.91 | 3 | 143217 | 12388 | 70772836 |
Immunodeficiency | 15.54 | 9.91 | 8 | 143212 | 17547 | 70767677 |
Product storage error | 15.51 | 9.91 | 5 | 143215 | 14536 | 70770688 |
Enteritis | 15.47 | 9.91 | 59 | 143161 | 12772 | 70772452 |
Joint effusion | 15.35 | 9.91 | 6 | 143214 | 15471 | 70769753 |
Gaze palsy | 15.32 | 9.91 | 23 | 143197 | 2715 | 70782509 |
Neuroglycopenia | 15.29 | 9.91 | 10 | 143210 | 421 | 70784803 |
Adrenal insufficiency | 15.21 | 9.91 | 95 | 143125 | 25100 | 70760124 |
Escherichia test positive | 15.20 | 9.91 | 24 | 143196 | 2959 | 70782265 |
Flail chest | 15.10 | 9.91 | 6 | 143214 | 85 | 70785139 |
Embolism | 15.07 | 9.91 | 59 | 143161 | 12929 | 70772295 |
Myoclonus | 15.06 | 9.91 | 98 | 143122 | 26257 | 70758967 |
Product quality issue | 15.05 | 9.91 | 24 | 143196 | 30537 | 70754687 |
Musculoskeletal disorder | 15.04 | 9.91 | 11 | 143209 | 19960 | 70765264 |
Stress cardiomyopathy | 15.04 | 9.91 | 49 | 143171 | 9813 | 70775411 |
Immune effector cell-associated neurotoxicity syndrome | 15.00 | 9.91 | 28 | 143192 | 3950 | 70781274 |
Spleen congestion | 14.99 | 9.91 | 10 | 143210 | 435 | 70784789 |
Foot deformity | 14.76 | 9.91 | 12 | 143208 | 20643 | 70764581 |
Therapy interrupted | 14.72 | 9.91 | 17 | 143203 | 24785 | 70760439 |
Balance disorder | 14.68 | 9.91 | 114 | 143106 | 90014 | 70695210 |
Tooth disorder | 14.65 | 9.91 | 16 | 143204 | 23922 | 70761302 |
Biliary dyskinesia | 14.65 | 9.91 | 21 | 143199 | 2378 | 70782846 |
Muscle spasticity | 14.63 | 9.91 | 11 | 143209 | 19678 | 70765546 |
Urinary tract infection | 14.61 | 9.91 | 628 | 142592 | 248141 | 70537083 |
Disturbance in social behaviour | 14.56 | 9.91 | 28 | 143192 | 4039 | 70781185 |
Mesothelioma | 14.51 | 9.91 | 9 | 143211 | 345 | 70784879 |
Ocular hyperaemia | 14.50 | 9.91 | 17 | 143203 | 24622 | 70760602 |
Chills | 14.49 | 9.91 | 389 | 142831 | 144397 | 70640827 |
Alanine aminotransferase increased | 14.41 | 9.91 | 395 | 142825 | 147085 | 70638139 |
Bacteraemia | 14.39 | 9.91 | 105 | 143115 | 29204 | 70756020 |
Hyperthermia malignant | 14.39 | 9.91 | 22 | 143198 | 2639 | 70782585 |
Oxygen saturation abnormal | 14.37 | 9.91 | 27 | 143193 | 3827 | 70781397 |
Muscle rigidity | 14.33 | 9.91 | 75 | 143145 | 18575 | 70766649 |
Joint stiffness | 14.33 | 9.91 | 31 | 143189 | 35145 | 70750079 |
Acanthosis | 14.31 | 9.91 | 10 | 143210 | 470 | 70784754 |
Clonus | 14.29 | 9.91 | 36 | 143184 | 6232 | 70778992 |
Intestinal obstruction | 14.15 | 9.91 | 130 | 143090 | 38695 | 70746529 |
Myalgia | 14.15 | 9.91 | 246 | 142974 | 167646 | 70617578 |
Laryngeal cancer metastatic | 14.15 | 9.91 | 5 | 143215 | 50 | 70785174 |
Bronchitis | 14.07 | 9.91 | 160 | 143060 | 117083 | 70668141 |
Heart rate irregular | 14.05 | 9.91 | 24 | 143196 | 29719 | 70755505 |
Sleep apnoea syndrome | 14.03 | 9.91 | 28 | 143192 | 32685 | 70752539 |
Porphyria acute | 13.97 | 9.91 | 15 | 143205 | 1264 | 70783960 |
Radiation pneumonitis | 13.93 | 9.91 | 26 | 143194 | 3667 | 70781557 |
Vitamin B12 decreased | 13.92 | 9.91 | 23 | 143197 | 2946 | 70782278 |
Mucosal erosion | 13.82 | 9.91 | 19 | 143201 | 2070 | 70783154 |
Seizure | 13.73 | 9.91 | 463 | 142757 | 177499 | 70607725 |
Extravasation blood | 13.71 | 9.91 | 9 | 143211 | 381 | 70784843 |
Cholelithiasis | 13.64 | 9.91 | 151 | 143069 | 47189 | 70738035 |
Hyperbilirubinaemia | 13.57 | 9.91 | 85 | 143135 | 22483 | 70762741 |
Inflammation | 13.53 | 9.91 | 98 | 143122 | 78567 | 70706657 |
Gallbladder injury | 13.45 | 9.91 | 14 | 143206 | 1138 | 70784086 |
Pulmonary sepsis | 13.38 | 9.91 | 24 | 143196 | 3283 | 70781941 |
No adverse event | 13.38 | 9.91 | 28 | 143192 | 32125 | 70753099 |
Heart sounds abnormal | 13.29 | 9.91 | 15 | 143205 | 1337 | 70783887 |
Superior vena cava occlusion | 13.18 | 9.91 | 7 | 143213 | 199 | 70785025 |
Hypotension | 13.16 | 9.91 | 967 | 142253 | 403414 | 70381810 |
Naevus haemorrhage | 13.08 | 9.91 | 6 | 143214 | 123 | 70785101 |
Circulatory collapse | 13.04 | 9.91 | 119 | 143101 | 35355 | 70749869 |
Blood sodium decreased | 12.97 | 9.91 | 107 | 143113 | 30891 | 70754333 |
Immune reconstitution inflammatory syndrome | 12.94 | 9.91 | 5 | 143215 | 12985 | 70772239 |
Neutropenic infection | 12.88 | 9.91 | 18 | 143202 | 1991 | 70783233 |
Dyspnoea | 12.87 | 9.91 | 1758 | 141462 | 768302 | 70016922 |
Tracheal injury | 12.84 | 9.91 | 5 | 143215 | 67 | 70785157 |
Delusional disorder, persecutory type | 12.80 | 9.91 | 9 | 143211 | 427 | 70784797 |
Gastric polyps | 12.80 | 9.91 | 24 | 143196 | 3397 | 70781827 |
Neutrophilic dermatosis | 12.79 | 9.91 | 10 | 143210 | 559 | 70784665 |
Muscle twitching | 12.75 | 9.91 | 76 | 143144 | 19751 | 70765473 |
Performance status decreased | 12.59 | 9.91 | 32 | 143188 | 5569 | 70779655 |
Vascular encephalopathy | 12.57 | 9.91 | 10 | 143210 | 573 | 70784651 |
Faecaloma | 12.55 | 9.91 | 48 | 143172 | 10403 | 70774821 |
Oesophageal ulcer | 12.48 | 9.91 | 35 | 143185 | 6459 | 70778765 |
COVID-19 treatment | 12.48 | 9.91 | 9 | 143211 | 445 | 70784779 |
Cytomegalovirus infection | 12.42 | 9.91 | 40 | 143180 | 39718 | 70745506 |
Post transplant lymphoproliferative disorder | 12.42 | 9.91 | 3 | 143217 | 10542 | 70774682 |
Aspartate aminotransferase increased | 12.38 | 9.91 | 340 | 142880 | 126638 | 70658586 |
Bladder cancer | 12.34 | 9.91 | 10 | 143210 | 17232 | 70767992 |
Vocal cord inflammation | 12.34 | 9.91 | 7 | 143213 | 227 | 70784997 |
Venous angioma of brain | 12.33 | 9.91 | 4 | 143216 | 30 | 70785194 |
Multiple sclerosis | 12.32 | 9.91 | 20 | 143200 | 25265 | 70759959 |
Joint dislocation | 12.31 | 9.91 | 7 | 143213 | 14524 | 70770700 |
Suicidal ideation | 12.31 | 9.91 | 86 | 143134 | 69510 | 70715714 |
Impaired work ability | 12.30 | 9.91 | 9 | 143211 | 16331 | 70768893 |
Lethargy | 12.29 | 9.91 | 217 | 143003 | 75033 | 70710191 |
Joint range of motion decreased | 12.29 | 9.91 | 21 | 143199 | 26005 | 70759219 |
Erectile dysfunction | 12.28 | 9.91 | 6 | 143214 | 13556 | 70771668 |
Aminoaciduria | 12.26 | 9.91 | 7 | 143213 | 230 | 70784994 |
Mania | 12.25 | 9.91 | 10 | 143210 | 17164 | 70768060 |
Carpal tunnel syndrome | 12.08 | 9.91 | 10 | 143210 | 17047 | 70768177 |
Seborrhoeic dermatitis | 12.08 | 9.91 | 17 | 143203 | 1893 | 70783331 |
Chemotherapeutic drug level increased | 12.06 | 9.91 | 8 | 143212 | 345 | 70784879 |
Poor quality sleep | 12.02 | 9.91 | 14 | 143206 | 20335 | 70764889 |
Paradoxical drug reaction | 12.01 | 9.91 | 35 | 143185 | 6601 | 70778623 |
Generalised oedema | 11.97 | 9.91 | 80 | 143140 | 21628 | 70763596 |
Acne | 11.95 | 9.91 | 20 | 143200 | 24969 | 70760255 |
Hypoglycaemic seizure | 11.93 | 9.91 | 11 | 143209 | 771 | 70784453 |
Underdose | 11.88 | 9.91 | 26 | 143194 | 29357 | 70755867 |
Pathogen resistance | 11.83 | 9.91 | 6 | 143214 | 13273 | 70771951 |
Leukoencephalopathy | 11.81 | 9.91 | 37 | 143183 | 7257 | 70777967 |
Abdominal tenderness | 11.76 | 9.91 | 45 | 143175 | 9755 | 70775469 |
Cardiac disorder | 11.74 | 9.91 | 71 | 143149 | 59344 | 70725880 |
Abdominal sepsis | 11.64 | 9.91 | 17 | 143203 | 1958 | 70783266 |
Generalised tonic-clonic seizure | 11.60 | 9.91 | 132 | 143088 | 41529 | 70743695 |
Metastatic malignant melanoma | 11.59 | 9.91 | 22 | 143198 | 3142 | 70782082 |
Eye pain | 11.59 | 9.91 | 33 | 143187 | 34069 | 70751155 |
Blood pH decreased | 11.59 | 9.91 | 27 | 143193 | 4449 | 70780775 |
Gastric disorder | 11.51 | 9.91 | 32 | 143188 | 33290 | 70751934 |
Visual impairment | 11.49 | 9.91 | 105 | 143115 | 80145 | 70705079 |
Lung perforation | 11.45 | 9.91 | 5 | 143215 | 91 | 70785133 |
Retching | 11.43 | 9.91 | 63 | 143157 | 15916 | 70769308 |
Sinus congestion | 11.33 | 9.91 | 11 | 143209 | 17362 | 70767862 |
Electrocardiogram change | 11.32 | 9.91 | 13 | 143207 | 1180 | 70784044 |
Respiratory failure | 11.29 | 9.91 | 432 | 142788 | 168303 | 70616921 |
Sinus disorder | 11.24 | 9.91 | 13 | 143207 | 18946 | 70766278 |
Blood aluminium increased | 11.24 | 9.91 | 3 | 143217 | 10 | 70785214 |
Injection site warmth | 11.23 | 9.91 | 7 | 143213 | 13818 | 70771406 |
Overdose | 11.21 | 9.91 | 259 | 142961 | 169486 | 70615738 |
Eastern Cooperative Oncology Group performance status worsened | 11.20 | 9.91 | 15 | 143205 | 1593 | 70783631 |
Drug tolerance decreased | 11.19 | 9.91 | 3 | 143217 | 9830 | 70775394 |
Glaucoma | 11.18 | 9.91 | 12 | 143208 | 18080 | 70767144 |
Aortitis | 11.14 | 9.91 | 14 | 143206 | 1397 | 70783827 |
Hypoacusis | 11.14 | 9.91 | 24 | 143196 | 27245 | 70757979 |
Foot fracture | 11.03 | 9.91 | 14 | 143206 | 19586 | 70765638 |
Vascular pain | 11.02 | 9.91 | 11 | 143209 | 851 | 70784373 |
Foetal malpresentation | 11.02 | 9.91 | 5 | 143215 | 100 | 70785124 |
Restless arm syndrome | 10.98 | 9.91 | 4 | 143216 | 44 | 70785180 |
Hyperemesis gravidarum | 10.98 | 9.91 | 8 | 143212 | 402 | 70784822 |
Dysuria | 10.96 | 9.91 | 141 | 143079 | 45653 | 70739571 |
Lung infiltration | 10.92 | 9.91 | 78 | 143142 | 21546 | 70763678 |
Increased tendency to bruise | 10.92 | 9.91 | 3 | 143217 | 9672 | 70775552 |
Abdominal compartment syndrome | 10.84 | 9.91 | 14 | 143206 | 1435 | 70783789 |
Peripheral venous disease | 10.84 | 9.91 | 4 | 143216 | 10683 | 70774541 |
Apallic syndrome | 10.80 | 9.91 | 11 | 143209 | 872 | 70784352 |
Type 2 diabetes mellitus | 10.77 | 9.91 | 49 | 143171 | 44031 | 70741193 |
Tooth fracture | 10.74 | 9.91 | 4 | 143216 | 10623 | 70774601 |
Prostate cancer | 10.71 | 9.91 | 30 | 143190 | 31133 | 70754091 |
Thoracic operation | 10.68 | 9.91 | 6 | 143214 | 191 | 70785033 |
Exostosis | 10.67 | 9.91 | 8 | 143212 | 14337 | 70770887 |
Erysipelas | 10.65 | 9.91 | 44 | 143176 | 9880 | 70775344 |
Back disorder | 10.64 | 9.91 | 4 | 143216 | 10560 | 70774664 |
Febrile infection | 10.64 | 9.91 | 21 | 143199 | 3088 | 70782136 |
Sciatica | 10.63 | 9.91 | 21 | 143199 | 24606 | 70760618 |
Myocardial reperfusion injury | 10.59 | 9.91 | 4 | 143216 | 49 | 70785175 |
Pericardial effusion | 10.59 | 9.91 | 130 | 143090 | 41646 | 70743578 |
Catheter site bruise | 10.57 | 9.91 | 7 | 143213 | 301 | 70784923 |
Dyschezia | 10.55 | 9.91 | 19 | 143201 | 2608 | 70782616 |
Progressive multifocal leukoencephalopathy | 10.53 | 9.91 | 14 | 143206 | 19200 | 70766024 |
Pregnancy | 10.50 | 9.91 | 20 | 143200 | 23761 | 70761463 |
Plantar erythema | 10.47 | 9.91 | 7 | 143213 | 306 | 70784918 |
Basal cell carcinoma | 10.46 | 9.91 | 34 | 143186 | 33664 | 70751560 |
Numb chin syndrome | 10.45 | 9.91 | 3 | 143217 | 14 | 70785210 |
Kounis syndrome | 10.44 | 9.91 | 22 | 143198 | 3389 | 70781835 |
Injection site mass | 10.43 | 9.91 | 13 | 143207 | 18330 | 70766894 |
Mood swings | 10.36 | 9.91 | 13 | 143207 | 18273 | 70766951 |
Disability | 10.34 | 9.91 | 9 | 143211 | 14974 | 70770250 |
Prostate cancer metastatic | 10.34 | 9.91 | 24 | 143196 | 3945 | 70781279 |
Disease recurrence | 10.30 | 9.91 | 40 | 143180 | 37563 | 70747661 |
Faecalith | 10.28 | 9.91 | 3 | 143217 | 15 | 70785209 |
Porphyria | 10.27 | 9.91 | 6 | 143214 | 206 | 70785018 |
Limb injury | 10.24 | 9.91 | 23 | 143197 | 25729 | 70759495 |
Peptic ulcer | 10.21 | 9.91 | 30 | 143190 | 5683 | 70779541 |
Transplant rejection | 10.21 | 9.91 | 13 | 143207 | 18158 | 70767066 |
Cyanosis | 10.20 | 9.91 | 81 | 143139 | 23125 | 70762099 |
Sinus tachycardia | 10.15 | 9.91 | 109 | 143111 | 33804 | 70751420 |
Multiple organ dysfunction syndrome | 10.14 | 9.91 | 289 | 142931 | 108226 | 70676998 |
Spinal cord injury thoracic | 10.07 | 9.91 | 5 | 143215 | 123 | 70785101 |
Eosinophilia | 10.02 | 9.91 | 125 | 143095 | 40194 | 70745030 |
Blood urea increased | 10.02 | 9.91 | 139 | 143081 | 45770 | 70739454 |
Haemorrhoids | 10.01 | 9.91 | 87 | 143133 | 25501 | 70759723 |
Ventricular fibrillation | 10.00 | 9.91 | 91 | 143129 | 27020 | 70758204 |
Tachypnoea | 9.99 | 9.91 | 95 | 143125 | 28543 | 70756681 |
Full blood count abnormal | 9.96 | 9.91 | 35 | 143185 | 33843 | 70751381 |
Immune-mediated enterocolitis | 9.92 | 9.91 | 22 | 143198 | 3509 | 70781715 |
Intercepted product administration error | 9.91 | 9.91 | 6 | 143214 | 220 | 70785004 |
None
Source | Code | Description |
---|---|---|
ATC | A03FA01 | ALIMENTARY TRACT AND METABOLISM DRUGS FOR FUNCTIONAL GASTROINTESTINAL DISORDERS PROPULSIVES Propulsives |
MeSH PA | D000932 | Antiemetics |
MeSH PA | D002491 | Central Nervous System Agents |
MeSH PA | D015259 | Dopamine Agents |
MeSH PA | D018492 | Dopamine Antagonists |
MeSH PA | D065127 | Dopamine D2 Receptor Antagonists |
MeSH PA | D005765 | Gastrointestinal Agents |
MeSH PA | D018377 | Neurotransmitter Agents |
MeSH PA | D018373 | Peripheral Nervous System Agents |
FDA MoA | N0000175799 | Dopamine D2 Antagonists |
FDA EPC | N0000175800 | Dopamine-2 Receptor Antagonist |
CHEBI has role | CHEBI:35703 | Xenobiotic |
CHEBI has role | CHEBI:48561 | dopaminergic antagonists |
CHEBI has role | CHEBI:50919 | antiemetico |
CHEBI has role | CHEBI:55324 | gastrointestinal drugs |
CHEBI has role | CHEBI:78298 | environmental contaminants |
Disease | Relation | SNOMED_ID | DOID |
---|---|---|---|
Diabetic gastroparesis | indication | 34140002 | |
Intubation of gastrointestinal tract | indication | 235419001 | |
Gastroesophageal reflux disease | indication | 235595009 | DOID:8534 |
Chemotherapy-induced nausea and vomiting | indication | 236084000 | |
Prevention of Post-Operative Nausea and Vomiting | indication | ||
Gastrointestinal Radiography Adjunct | indication | ||
Suicidal thoughts | contraindication | 6471006 | |
Neuroleptic malignant syndrome | contraindication | 15244003 | DOID:14464 |
Cirrhosis of liver | contraindication | 19943007 | DOID:5082 |
Parkinsonism | contraindication | 32798002 | |
Depressive disorder | contraindication | 35489007 | |
Hypertensive disorder | contraindication | 38341003 | DOID:10763 |
Body fluid retention | contraindication | 43498006 | |
Mechanical ileus | contraindication | 46420000 | |
Chronic heart failure | contraindication | 48447003 | |
Gastrointestinal perforation | contraindication | 51875005 | |
Gastrointestinal hemorrhage | contraindication | 74474003 | |
Tardive dyskinesia | contraindication | 102449007 | |
Deficiency of cytochrome-b>5< reductase | contraindication | 124184009 | |
Seizure disorder | contraindication | 128613002 | |
Impaired renal function disorder | contraindication | 197663003 | |
Anastomosis of intestine | contraindication | 235407009 | |
Pheochromocytoma | contraindication | 302835009 | |
Porphyria | contraindication | 418470004 | |
Acquired torsion dystonia | contraindication | 433493000 |
None
None
Dissociation level | Dissociation constant | Type (acidic/basic) |
---|---|---|
pKa1 | 13.17 | acidic |
pKa2 | 8.94 | Basic |
pKa3 | 1.08 | Basic |
Formulation strength | Trade name | Applicant | Application number | Approval date | Type | Dose form | Route | Patent number | Patent expiration date | Patent use |
---|---|---|---|---|---|---|---|---|---|---|
EQ 15MG BASE/SPRAY | GIMOTI | EVOKE PHARMA INC | N209388 | June 19, 2020 | RX | SPRAY, METERED | NASAL | 11020361 | Dec. 22, 2029 | NASAL ADMINISTRATION OF METOCLOPRAMIDE FOR TREATMENT OF DIABETIC GASTROPARESIS |
EQ 15MG BASE/SPRAY | GIMOTI | EVOKE PHARMA INC | N209388 | June 19, 2020 | RX | SPRAY, METERED | NASAL | 8334281 | May 16, 2030 | NASAL ADMINISTRATION OF METOCLOPRAMIDE FOR TREATMENT OF DIABETIC GASTROPARESIS |
Formulation strength | Trade name | Applicant | Application number | Approval date | Type | Dose form | Route | Exclusivity date | Description |
---|---|---|---|---|---|---|---|---|---|
EQ 15MG BASE/SPRAY | GIMOTI | EVOKE PHARMA INC | N209388 | June 19, 2020 | RX | SPRAY, METERED | NASAL | June 19, 2023 | NEW PRODUCT |
Target | Class | Pharos | UniProt | Action | Type | Activity value (-log[M]) | Mechanism action | Bioact source | MoA source |
---|---|---|---|---|---|---|---|---|---|
D(2) dopamine receptor | GPCR | ANTAGONIST | Ki | 7.19 | WOMBAT-PK | CHEMBL | |||
5-hydroxytryptamine receptor 3A | Ion channel | ANTAGONIST | Ki | 6.70 | WOMBAT-PK | CHEMBL | |||
5-hydroxytryptamine receptor 4 | GPCR | AGONIST | EC50 | 6 | WOMBAT-PK | CHEMBL | |||
5-hydroxytryptamine receptor 2B | GPCR | Ki | 6.40 | DRUG MATRIX | |||||
5-hydroxytryptamine receptor 2C | GPCR | Ki | 5.90 | DRUG MATRIX | |||||
D(3) dopamine receptor | GPCR | Ki | 7.66 | WOMBAT-PK | |||||
Muscarinic acetylcholine receptor M1 | GPCR | WOMBAT-PK | |||||||
Aldehyde oxidase | Enzyme | IC50 | 4.51 | WOMBAT-PK | |||||
Cytochrome P450 2D6 | Enzyme | IC50 | 6.10 | DRUG MATRIX | |||||
Myeloperoxidase | Enzyme | IC50 | 6.46 | CHEMBL | |||||
Solute carrier family 22 member 1 | Transporter | IC50 | 4.02 | CHEMBL | |||||
Serotonin 3 (5-HT3) receptor | Ion channel | Kd | 7.30 | CHEMBL | |||||
Alpha-2A adrenergic receptor | GPCR | Ki | 5.99 | DRUG MATRIX | |||||
5-hydroxytryptamine receptor 2A | GPCR | Ki | 5.98 | DRUG MATRIX | |||||
D(2) dopamine receptor | GPCR | Ki | 6.98 | CHEMBL | |||||
D(2) dopamine receptor | GPCR | Ki | 7.10 | CHEMBL | |||||
D(2) dopamine receptor | GPCR | ANTAGONIST | Ki | 7.54 | IUPHAR | ||||
5-hydroxytryptamine receptor 4 | GPCR | Ki | 6.05 | CHEMBL | |||||
D(3) dopamine receptor | GPCR | IC50 | 7.21 | CHEMBL | |||||
Serotonin 3 (5-HT3) receptor | Ion channel | Ki | 6.68 | CHEMBL | |||||
Serotonin 1 (5-HT1) receptor | GPCR | IC50 | 5.11 | CHEMBL | |||||
Adrenergic receptor alpha-2 | GPCR | IC50 | 5.11 | CHEMBL | |||||
Adrenergic receptor alpha-1 | GPCR | IC50 | 4.48 | CHEMBL | |||||
Serotonin 2 (5-HT2) receptor | GPCR | IC50 | 4.88 | CHEMBL | |||||
Serotonin 3 receptor (5HT3) | Ion channel | Ki | 6.70 | CHEMBL | |||||
5-hydroxytryptamine receptor 4 | GPCR | Ki | 6.26 | CHEMBL | |||||
5-hydroxytryptamine receptor 4 | GPCR | AGONIST | Ki | 6 | IUPHAR |
ID | Source |
---|---|
4019835 | VUID |
N0000147923 | NUI |
D00726 | KEGG_DRUG |
54143-57-6 | SECONDARY_CAS_RN |
4017905 | VANDF |
4019835 | VANDF |
C0025853 | UMLSCUI |
CHEBI:107736 | CHEBI |
CHEMBL86 | ChEMBL_ID |
DB01233 | DRUGBANK_ID |
CHEMBL1200940 | ChEMBL_ID |
CHEMBL1256771 | ChEMBL_ID |
D008787 | MESH_DESCRIPTOR_UI |
4168 | PUBCHEM_CID |
241 | IUPHAR_LIGAND_ID |
1740 | INN_ID |
L4YEB44I46 | UNII |
267036 | RXNORM |
1062 | MMSL |
34842 | MMSL |
5099 | MMSL |
d00298 | MMSL |
001877 | NDDF |
004778 | NDDF |
31147000 | SNOMEDCT_US |
372776000 | SNOMEDCT_US |
56549003 | SNOMEDCT_US |
Product | Category | Ingredients | NDC | Form | Quantity | Route | Marketing | Label |
---|---|---|---|---|---|---|---|---|
Metoclopramide | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0093-2203 | TABLET | 10 mg | ORAL | ANDA | 26 sections |
Metoclopramide | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0093-2204 | TABLET | 5 mg | ORAL | ANDA | 26 sections |
Metoclopramide | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0121-0576 | SOLUTION | 5 mg | ORAL | ANDA | 28 sections |
Metoclopramide | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0121-0576 | SOLUTION | 5 mg | ORAL | ANDA | 28 sections |
Metoclopramide | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0121-1576 | SOLUTION | 5 mg | ORAL | ANDA | 28 sections |
Metoclopramide | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0121-1576 | SOLUTION | 5 mg | ORAL | ANDA | 28 sections |
Metoclopramide | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0404-9910 | INJECTION, SOLUTION | 5 mg | INTRAVENOUS | ANDA | 13 sections |
Metoclopramide | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0404-9910 | INJECTION, SOLUTION | 5 mg | INTRAVENOUS | ANDA | 13 sections |
Metoclopramide | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0409-3414 | INJECTION, SOLUTION | 5 mg | INTRAMUSCULAR | ANDA | 15 sections |
Metoclopramide | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0409-5255 | INJECTION, SOLUTION | 5 mg | INTRAMUSCULAR | ANDA | 22 sections |
Metoclopramide | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0440-1771 | TABLET | 10 mg | ORAL | ANDA | 22 sections |
Metoclopramide | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0615-7698 | TABLET | 5 mg | ORAL | ANDA | 27 sections |
Metoclopramide | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0615-7698 | TABLET | 5 mg | ORAL | ANDA | 27 sections |
Metoclopramide | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0615-8285 | TABLET | 10 mg | ORAL | ANDA | 27 sections |
Metoclopramide | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0615-8285 | TABLET | 10 mg | ORAL | ANDA | 27 sections |
Metoclopramide | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0703-4502 | INJECTION, SOLUTION | 5 mg | INTRAMUSCULAR | ANDA | 23 sections |
Metoclopramide | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0703-4502 | INJECTION, SOLUTION | 5 mg | INTRAMUSCULAR | ANDA | 23 sections |
Metoclopramide | HUMAN PRESCRIPTION DRUG LABEL | 1 | 12634-112 | TABLET | 10 mg | ORAL | ANDA | 22 sections |
METOCLOPRAMIDE | HUMAN PRESCRIPTION DRUG LABEL | 1 | 16590-150 | TABLET | 5 mg | ORAL | ANDA | 25 sections |
METOCLOPRAMIDE | HUMAN PRESCRIPTION DRUG LABEL | 1 | 16590-151 | TABLET | 10 mg | ORAL | ANDA | 25 sections |
REGLAN | HUMAN PRESCRIPTION DRUG LABEL | 1 | 16590-906 | TABLET | 10 mg | ORAL | NDA | 24 sections |
Metoclopramide | HUMAN PRESCRIPTION DRUG LABEL | 1 | 17856-0576 | SOLUTION | 5 mg | ORAL | ANDA | 24 sections |
Metoclopramide | HUMAN PRESCRIPTION DRUG LABEL | 1 | 21695-346 | TABLET | 10 mg | ORAL | ANDA | 19 sections |
Metoclopramide | HUMAN PRESCRIPTION DRUG LABEL | 1 | 21695-485 | TABLET | 5 mg | ORAL | ANDA | 19 sections |
Metoclopramide | HUMAN PRESCRIPTION DRUG LABEL | 1 | 23155-240 | INJECTION | 5 mg | INTRAMUSCULAR | ANDA | 21 sections |
Metoclopramide | HUMAN PRESCRIPTION DRUG LABEL | 1 | 33261-166 | TABLET | 10 mg | ORAL | ANDA | 22 sections |
METOCLOPRAMIDE hydrochloride | HUMAN PRESCRIPTION DRUG LABEL | 1 | 40032-580 | TABLET, ORALLY DISINTEGRATING | 10 mg | ORAL | ANDA | 25 sections |
METOCLOPRAMIDE hydrochloride | HUMAN PRESCRIPTION DRUG LABEL | 1 | 40032-581 | TABLET, ORALLY DISINTEGRATING | 5 mg | ORAL | ANDA | 25 sections |
Metoclopramide Hydrochloride | HUMAN PRESCRIPTION DRUG LABEL | 1 | 42254-196 | TABLET | 5 mg | ORAL | ANDA | 22 sections |
Metoclopramide Hydrochloride | HUMAN PRESCRIPTION DRUG LABEL | 1 | 42254-266 | TABLET | 10 mg | ORAL | ANDA | 22 sections |