metoclopramide Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |
| Stem definition | Drug id | CAS RN |
|---|---|---|
| sulpiride derivatives | 1782 | 364-62-5 |
Description:
| Molecule | Description |
|---|---|
|
Synonyms:
|
A dopamine D2 antagonist that is used as an antiemetic.
Legend: OFP - off patent OFM - off market ONP - on patent |
Drug dosage:
| Dose | Unit | Route |
|---|---|---|
| 30 | mg | O |
| 30 | mg | P |
| 30 | mg | R |
ADMET properties:
| Property | Value | Reference |
|---|---|---|
| MRTD (Maximum Recommended Therapeutic Daily Dose) | 33.36 µM/kg/day | Contrera JF, Matthews EJ, Kruhlak NL, Benz RD |
| BDDCS (Biopharmaceutical Drug Disposition Classification System) | 1 | Hosey CM, Chan R, Benet LZ |
| S (Water solubility) | 0.20 mg/mL | Hosey CM, Chan R, Benet LZ |
| EoM (Fraction excreted unchanged in urine) | 20 % | Hosey CM, Chan R, Benet LZ |
| BA (Bioavailability) | 76 % | Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H |
| Vd (Volume of distribution) | 3.20 L/kg | Lombardo F, Berellini G, Obach RS |
| CL (Clearance) | 5.70 mL/min/kg | Lombardo F, Berellini G, Obach RS |
| fu (Fraction unbound in plasma) | 0.60 % | Lombardo F, Berellini G, Obach RS |
| t_half (Half-life) | 7.20 hours | Lombardo F, Berellini G, Obach RS |
Approvals:
| Date | Agency | Company | Orphan |
|---|---|---|---|
| Feb. 7, 1979 | FDA | BAXTER HLTHCARE CORP |
FDA Adverse Event Reporting System (Female)
| MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
|---|---|---|---|---|---|---|
| Drug ineffective | 401.29 | 9.62 | 416 | 87801 | 677422 | 45920423 |
| Vomiting | 348.76 | 9.62 | 1731 | 86486 | 451063 | 46146782 |
| Rheumatoid arthritis | 315.30 | 9.62 | 41 | 88176 | 240174 | 46357671 |
| Febrile neutropenia | 252.11 | 9.62 | 554 | 87663 | 94073 | 46503772 |
| Nausea | 215.85 | 9.62 | 2109 | 86108 | 685345 | 45912500 |
| Drug intolerance | 126.16 | 9.62 | 60 | 88157 | 146989 | 46450856 |
| Joint swelling | 126.15 | 9.62 | 79 | 88138 | 165994 | 46431851 |
| General physical health deterioration | 117.13 | 9.62 | 481 | 87736 | 115288 | 46482557 |
| Impaired gastric emptying | 112.87 | 9.62 | 105 | 88112 | 7967 | 46589878 |
| Injection site pain | 111.60 | 9.62 | 32 | 88185 | 107120 | 46490725 |
| Dystonia | 110.68 | 9.62 | 121 | 88096 | 11136 | 46586709 |
| Pyrexia | 110.49 | 9.62 | 1074 | 87143 | 347728 | 46250117 |
| Completed suicide | 108.64 | 9.62 | 71 | 88146 | 145849 | 46451996 |
| Arthralgia | 106.71 | 9.62 | 344 | 87873 | 364259 | 46233586 |
| Dehydration | 100.79 | 9.62 | 579 | 87638 | 158961 | 46438884 |
| Contraindicated product administered | 94.87 | 9.62 | 18 | 88199 | 79929 | 46517916 |
| Hypokalaemia | 94.81 | 9.62 | 373 | 87844 | 87651 | 46510194 |
| Product dose omission issue | 91.76 | 9.62 | 110 | 88107 | 168410 | 46429435 |
| Tardive dyskinesia | 90.14 | 9.62 | 90 | 88127 | 7453 | 46590392 |
| Therapeutic product effect decreased | 87.24 | 9.62 | 24 | 88193 | 82577 | 46515268 |
| Weight increased | 82.67 | 9.62 | 114 | 88103 | 164359 | 46433486 |
| Serotonin syndrome | 76.28 | 9.62 | 152 | 88065 | 24068 | 46573777 |
| Psoriasis | 73.89 | 9.62 | 28 | 88189 | 78576 | 46519269 |
| Neutropenia | 73.62 | 9.62 | 493 | 87724 | 142711 | 46455134 |
| Toxic epidermal necrolysis | 72.81 | 9.62 | 142 | 88075 | 22136 | 46575709 |
| Treatment failure | 72.42 | 9.62 | 43 | 88174 | 93044 | 46504801 |
| Synovitis | 71.93 | 9.62 | 14 | 88203 | 61061 | 46536784 |
| Abdominal pain | 70.07 | 9.62 | 703 | 87514 | 229328 | 46368517 |
| Neutropenic sepsis | 69.05 | 9.62 | 100 | 88117 | 12224 | 46585621 |
| Arthropathy | 67.49 | 9.62 | 38 | 88179 | 84662 | 46513183 |
| Constipation | 67.18 | 9.62 | 560 | 87657 | 173537 | 46424308 |
| Therapeutic product effect incomplete | 66.82 | 9.62 | 32 | 88185 | 78121 | 46519724 |
| Atelectasis | 65.38 | 9.62 | 123 | 88094 | 18667 | 46579178 |
| Phaeochromocytoma crisis | 65.03 | 9.62 | 21 | 88196 | 167 | 46597678 |
| Malignant neoplasm progression | 65.00 | 9.62 | 269 | 87948 | 64657 | 46533188 |
| Sinusitis | 64.14 | 9.62 | 91 | 88126 | 129677 | 46468168 |
| Decreased appetite | 62.72 | 9.62 | 600 | 87617 | 193236 | 46404609 |
| Cholecystitis chronic | 60.00 | 9.62 | 86 | 88131 | 10413 | 46587432 |
| Extrapyramidal disorder | 59.62 | 9.62 | 89 | 88128 | 11179 | 46586666 |
| Hyponatraemia | 56.41 | 9.62 | 356 | 87861 | 100976 | 46496869 |
| Swelling | 56.07 | 9.62 | 93 | 88124 | 124418 | 46473427 |
| Torsade de pointes | 55.91 | 9.62 | 90 | 88127 | 12064 | 46585781 |
| Thrombocytopenia | 52.49 | 9.62 | 414 | 87803 | 126167 | 46471678 |
| Nasopharyngitis | 51.68 | 9.62 | 136 | 88081 | 153862 | 46443983 |
| Electrocardiogram QT prolonged | 50.85 | 9.62 | 212 | 88005 | 51113 | 46546732 |
| Hand deformity | 50.18 | 9.62 | 4 | 88213 | 34570 | 46563275 |
| Gastritis | 49.24 | 9.62 | 160 | 88057 | 34218 | 46563627 |
| Mucosal inflammation | 48.45 | 9.62 | 173 | 88044 | 38803 | 46559042 |
| Renal ischaemia | 47.26 | 9.62 | 23 | 88194 | 580 | 46597265 |
| Product use issue | 47.12 | 9.62 | 66 | 88151 | 94578 | 46503267 |
| Pain | 46.81 | 9.62 | 628 | 87589 | 476320 | 46121525 |
| Abdominal discomfort | 45.93 | 9.62 | 140 | 88077 | 151025 | 46446820 |
| Hypomagnesaemia | 44.96 | 9.62 | 117 | 88100 | 22093 | 46575752 |
| Injection site bruising | 44.51 | 9.62 | 7 | 88210 | 35629 | 46562216 |
| Peripheral swelling | 44.13 | 9.62 | 152 | 88065 | 157919 | 46439926 |
| Computerised tomogram thorax abnormal | 43.84 | 9.62 | 29 | 88188 | 1332 | 46596513 |
| Subileus | 43.80 | 9.62 | 40 | 88177 | 2963 | 46594882 |
| Psoriatic arthropathy | 43.56 | 9.62 | 8 | 88209 | 36371 | 46561474 |
| Injection site erythema | 43.28 | 9.62 | 46 | 88171 | 74381 | 46523464 |
| Diabetes insipidus | 41.97 | 9.62 | 34 | 88183 | 2140 | 46595705 |
| Pulmonary embolism | 39.57 | 9.62 | 345 | 87872 | 108240 | 46489605 |
| Restlessness | 39.48 | 9.62 | 122 | 88095 | 25402 | 46572443 |
| Ileus | 39.27 | 9.62 | 84 | 88133 | 13980 | 46583865 |
| PO2 increased | 38.85 | 9.62 | 23 | 88194 | 867 | 46596978 |
| Duodenal stenosis | 38.79 | 9.62 | 20 | 88197 | 572 | 46597273 |
| PCO2 increased | 38.65 | 9.62 | 26 | 88191 | 1228 | 46596617 |
| Device expulsion | 37.79 | 9.62 | 4 | 88213 | 27538 | 46570307 |
| Electrolyte imbalance | 37.20 | 9.62 | 93 | 88124 | 17133 | 46580712 |
| Anaemia | 36.74 | 9.62 | 683 | 87534 | 255096 | 46342749 |
| Arthritis | 36.44 | 9.62 | 56 | 88161 | 77260 | 46520585 |
| Acute kidney injury | 36.41 | 9.62 | 637 | 87580 | 235218 | 46362627 |
| Fall | 36.08 | 9.62 | 423 | 87794 | 328674 | 46269171 |
| Systemic lupus erythematosus | 36.02 | 9.62 | 42 | 88175 | 65138 | 46532707 |
| Injection site pruritus | 35.96 | 9.62 | 15 | 88202 | 39728 | 46558117 |
| Hypoxia | 35.90 | 9.62 | 193 | 88024 | 51645 | 46546200 |
| Blood bicarbonate decreased | 35.54 | 9.62 | 35 | 88182 | 2850 | 46594995 |
| Diarrhoea | 35.48 | 9.62 | 1341 | 86876 | 558261 | 46039584 |
| Injection site swelling | 35.25 | 9.62 | 16 | 88201 | 40311 | 46557534 |
| Dyskinesia | 34.76 | 9.62 | 127 | 88090 | 28798 | 46569047 |
| Wrong technique in product usage process | 34.69 | 9.62 | 31 | 88186 | 54391 | 46543454 |
| Akathisia | 33.96 | 9.62 | 56 | 88161 | 7658 | 46590187 |
| Stevens-Johnson syndrome | 33.87 | 9.62 | 109 | 88108 | 23188 | 46574657 |
| Musculoskeletal stiffness | 33.27 | 9.62 | 86 | 88131 | 97907 | 46499938 |
| Abortion spontaneous | 32.77 | 9.62 | 21 | 88196 | 43625 | 46554220 |
| Glossodynia | 32.43 | 9.62 | 22 | 88195 | 44351 | 46553494 |
| Gastroenteritis | 32.26 | 9.62 | 110 | 88107 | 24109 | 46573736 |
| Oculogyric crisis | 32.00 | 9.62 | 23 | 88194 | 1210 | 46596635 |
| Injection site reaction | 30.81 | 9.62 | 27 | 88190 | 47822 | 46550023 |
| Left ventricular dysfunction | 30.67 | 9.62 | 63 | 88154 | 10192 | 46587653 |
| Encephalopathy | 30.39 | 9.62 | 135 | 88082 | 33454 | 46564391 |
| Pleural effusion | 29.92 | 9.62 | 263 | 87954 | 82689 | 46515156 |
| Cytokine release syndrome | 29.89 | 9.62 | 47 | 88170 | 6176 | 46591669 |
| Sepsis | 29.75 | 9.62 | 390 | 87827 | 135624 | 46462221 |
| Infusion site streaking | 29.28 | 9.62 | 14 | 88203 | 339 | 46597506 |
| Cholecystitis | 29.06 | 9.62 | 76 | 88141 | 14390 | 46583455 |
| Blood pressure increased | 28.86 | 9.62 | 132 | 88085 | 126534 | 46471311 |
| Phaeochromocytoma | 28.35 | 9.62 | 15 | 88202 | 453 | 46597392 |
| Hyperprolactinaemia | 27.92 | 9.62 | 31 | 88186 | 2901 | 46594944 |
| Antinuclear antibody negative | 27.76 | 9.62 | 12 | 88205 | 228 | 46597617 |
| Hepatocellular injury | 27.73 | 9.62 | 120 | 88097 | 29402 | 46568443 |
| Cataract | 27.61 | 9.62 | 27 | 88190 | 45388 | 46552457 |
| Influenza | 27.58 | 9.62 | 82 | 88135 | 89188 | 46508657 |
| Leukopenia | 27.47 | 9.62 | 222 | 87995 | 68121 | 46529724 |
| Septic shock | 27.16 | 9.62 | 195 | 88022 | 57698 | 46540147 |
| Tachycardia | 26.74 | 9.62 | 297 | 87920 | 99325 | 46498520 |
| Herpes simplex reactivation | 26.03 | 9.62 | 13 | 88204 | 347 | 46597498 |
| Neutrophil count decreased | 25.67 | 9.62 | 155 | 88062 | 43271 | 46554574 |
| Respiratory dyskinesia | 25.51 | 9.62 | 7 | 88210 | 29 | 46597816 |
| Blood pH decreased | 25.41 | 9.62 | 28 | 88189 | 2599 | 46595246 |
| Immune effector cell-associated neurotoxicity syndrome | 25.34 | 9.62 | 16 | 88201 | 678 | 46597167 |
| Coombs positive haemolytic anaemia | 25.05 | 9.62 | 13 | 88204 | 377 | 46597468 |
| Confusional state | 24.70 | 9.62 | 432 | 87785 | 159460 | 46438385 |
| Malnutrition | 24.57 | 9.62 | 70 | 88147 | 13933 | 46583912 |
| Rash maculo-papular | 24.44 | 9.62 | 111 | 88106 | 27763 | 46570082 |
| Gastritis haemorrhagic | 24.05 | 9.62 | 20 | 88197 | 1306 | 46596539 |
| Respiratory syncytial virus infection | 23.89 | 9.62 | 37 | 88180 | 4798 | 46593047 |
| Small intestinal obstruction | 23.81 | 9.62 | 76 | 88141 | 16096 | 46581749 |
| Osteoarthritis | 23.79 | 9.62 | 51 | 88166 | 61974 | 46535871 |
| No adverse event | 23.67 | 9.62 | 18 | 88199 | 34213 | 46563632 |
| Therapeutic response decreased | 23.62 | 9.62 | 28 | 88189 | 43117 | 46554728 |
| Erysipelas | 23.61 | 9.62 | 45 | 88172 | 6893 | 46590952 |
| Mixed liver injury | 22.93 | 9.62 | 29 | 88188 | 3114 | 46594731 |
| Gelastic seizure | 22.91 | 9.62 | 5 | 88212 | 5 | 46597840 |
| Aplastic anaemia | 22.65 | 9.62 | 45 | 88172 | 7108 | 46590737 |
| Accidental exposure to product | 22.48 | 9.62 | 6 | 88211 | 21075 | 46576770 |
| Excessive eye blinking | 22.43 | 9.62 | 14 | 88203 | 581 | 46597264 |
| Hyponatraemic seizure | 22.35 | 9.62 | 13 | 88204 | 474 | 46597371 |
| Asthma | 22.30 | 9.62 | 93 | 88124 | 91449 | 46506396 |
| Polydipsia | 21.96 | 9.62 | 29 | 88188 | 3250 | 46594595 |
| Delusional disorder, persecutory type | 21.90 | 9.62 | 9 | 88208 | 150 | 46597695 |
| Off label use | 21.50 | 9.62 | 550 | 87667 | 379291 | 46218554 |
| Carcinoid tumour of the stomach | 21.47 | 9.62 | 9 | 88208 | 158 | 46597687 |
| Aquagenic pruritus | 21.46 | 9.62 | 6 | 88211 | 27 | 46597818 |
| Cardiac arrest | 21.37 | 9.62 | 263 | 87954 | 90136 | 46507709 |
| Condition aggravated | 21.36 | 9.62 | 330 | 87887 | 244722 | 46353123 |
| Blood magnesium decreased | 21.32 | 9.62 | 57 | 88160 | 10935 | 46586910 |
| Oxygen saturation abnormal | 21.31 | 9.62 | 26 | 88191 | 2692 | 46595153 |
| Knee arthroplasty | 21.30 | 9.62 | 9 | 88208 | 23656 | 46574189 |
| Intentional overdose | 21.27 | 9.62 | 58 | 88159 | 64886 | 46532959 |
| Ascites | 21.25 | 9.62 | 130 | 88087 | 36454 | 46561391 |
| Hypergastrinaemia | 21.20 | 9.62 | 8 | 88209 | 105 | 46597740 |
| Enterochromaffin cell hyperplasia | 21.11 | 9.62 | 7 | 88210 | 61 | 46597784 |
| Blood pressure fluctuation | 21.07 | 9.62 | 16 | 88201 | 30432 | 46567413 |
| Adverse drug reaction | 21.03 | 9.62 | 32 | 88185 | 44330 | 46553515 |
| C-reactive protein abnormal | 20.96 | 9.62 | 7 | 88210 | 21263 | 46576582 |
| Product quality issue | 20.75 | 9.62 | 22 | 88195 | 35626 | 46562219 |
| Urticaria | 20.70 | 9.62 | 134 | 88083 | 117758 | 46480087 |
| Mobility decreased | 20.70 | 9.62 | 53 | 88164 | 60541 | 46537304 |
| Abdominal pain upper | 20.13 | 9.62 | 386 | 87831 | 144919 | 46452926 |
| Injection site haemorrhage | 20.09 | 9.62 | 7 | 88210 | 20702 | 46577143 |
| Malignant polyp | 20.09 | 9.62 | 9 | 88208 | 187 | 46597658 |
| Dysphagia | 20.07 | 9.62 | 229 | 87988 | 77083 | 46520762 |
| Neuropathy peripheral | 20.02 | 9.62 | 261 | 87956 | 90632 | 46507213 |
| Duodenal perforation | 19.98 | 9.62 | 15 | 88202 | 844 | 46597001 |
| Clonus | 19.85 | 9.62 | 31 | 88186 | 4049 | 46593796 |
| Foetal death | 19.72 | 9.62 | 48 | 88169 | 8695 | 46589150 |
| Thymus disorder | 19.66 | 9.62 | 9 | 88208 | 197 | 46597648 |
| Hip arthroplasty | 19.61 | 9.62 | 5 | 88212 | 18107 | 46579738 |
| Osteoporosis | 19.53 | 9.62 | 29 | 88188 | 40579 | 46557266 |
| Contusion | 19.43 | 9.62 | 92 | 88125 | 87395 | 46510450 |
| Pain in extremity | 19.41 | 9.62 | 358 | 87859 | 258322 | 46339523 |
| Ejection fraction decreased | 19.27 | 9.62 | 76 | 88141 | 17861 | 46579984 |
| Aortic rupture | 19.27 | 9.62 | 7 | 88210 | 82 | 46597763 |
| Inappropriate schedule of product administration | 19.17 | 9.62 | 61 | 88156 | 64952 | 46532893 |
| Terminal ileitis | 19.16 | 9.62 | 8 | 88209 | 139 | 46597706 |
| Headache | 18.96 | 9.62 | 726 | 87491 | 477626 | 46120219 |
| Anxiety disorder | 18.96 | 9.62 | 28 | 88189 | 3483 | 46594362 |
| Radiation pneumonitis | 18.84 | 9.62 | 17 | 88200 | 1240 | 46596605 |
| Catheter site bruise | 18.81 | 9.62 | 10 | 88207 | 305 | 46597540 |
| Hypocalcaemia | 18.72 | 9.62 | 100 | 88117 | 26685 | 46571160 |
| Myalgia | 18.64 | 9.62 | 146 | 88071 | 122942 | 46474903 |
| Red blood cell sedimentation rate increased | 18.61 | 9.62 | 10 | 88207 | 22879 | 46574966 |
| Aplasia | 18.57 | 9.62 | 28 | 88189 | 3548 | 46594297 |
| Onychalgia | 18.56 | 9.62 | 13 | 88204 | 656 | 46597189 |
| Herpes zoster | 18.43 | 9.62 | 66 | 88151 | 67806 | 46530039 |
| Acute interstitial pneumonitis | 18.20 | 9.62 | 13 | 88204 | 677 | 46597168 |
| Blood calcium decreased | 18.15 | 9.62 | 68 | 88149 | 15605 | 46582240 |
| Alveolitis | 18.04 | 9.62 | 23 | 88194 | 2490 | 46595355 |
| Heart rate decreased | 18.00 | 9.62 | 20 | 88197 | 31703 | 46566142 |
| Neuroleptic malignant syndrome | 17.98 | 9.62 | 54 | 88163 | 11068 | 46586777 |
| Bronchitis | 17.83 | 9.62 | 122 | 88095 | 105857 | 46491988 |
| Gait disturbance | 17.75 | 9.62 | 182 | 88035 | 145081 | 46452764 |
| Vitamin B12 decreased | 17.75 | 9.62 | 24 | 88193 | 2751 | 46595094 |
| Multiple organ dysfunction syndrome | 17.64 | 9.62 | 162 | 88055 | 51548 | 46546297 |
| Obstruction gastric | 17.55 | 9.62 | 14 | 88203 | 862 | 46596983 |
| Plantar erythema | 17.53 | 9.62 | 9 | 88208 | 255 | 46597590 |
| Torticollis | 17.38 | 9.62 | 19 | 88198 | 1748 | 46596097 |
| Oesophagitis | 17.31 | 9.62 | 61 | 88156 | 13590 | 46584255 |
| Parkinsonism | 17.26 | 9.62 | 43 | 88174 | 7905 | 46589940 |
| Intentional product misuse | 17.05 | 9.62 | 40 | 88177 | 47088 | 46550757 |
| Colitis | 17.05 | 9.62 | 125 | 88092 | 37222 | 46560623 |
| Pancytopenia | 16.99 | 9.62 | 240 | 87977 | 84818 | 46513027 |
| Hospitalisation | 16.97 | 9.62 | 62 | 88155 | 63323 | 46534522 |
| Pancreatitis | 16.60 | 9.62 | 140 | 88077 | 43487 | 46554358 |
| Hypoglycaemic seizure | 16.59 | 9.62 | 11 | 88206 | 507 | 46597338 |
| Staring | 16.58 | 9.62 | 17 | 88200 | 1453 | 46596392 |
| Haematemesis | 16.50 | 9.62 | 102 | 88115 | 28704 | 46569141 |
| Hypochloraemia | 16.47 | 9.62 | 19 | 88198 | 1854 | 46595991 |
| Hepatic enzyme increased | 16.45 | 9.62 | 89 | 88128 | 81698 | 46516147 |
| Peritonitis | 16.34 | 9.62 | 80 | 88137 | 20634 | 46577211 |
| Hypophagia | 16.31 | 9.62 | 103 | 88114 | 29203 | 46568642 |
| Biliary dyskinesia | 16.26 | 9.62 | 23 | 88194 | 2750 | 46595095 |
| Acute abdomen | 15.99 | 9.62 | 17 | 88200 | 1515 | 46596330 |
| Cholestasis | 15.90 | 9.62 | 96 | 88121 | 26797 | 46571048 |
| Haemangioma of skin | 15.88 | 9.62 | 9 | 88208 | 312 | 46597533 |
| Gallbladder injury | 15.69 | 9.62 | 16 | 88201 | 1358 | 46596487 |
| Diabetic gastroparesis | 15.67 | 9.62 | 8 | 88209 | 224 | 46597621 |
| Peripheral circulatory failure | 15.40 | 9.62 | 9 | 88208 | 331 | 46597514 |
| Respiratory failure | 15.28 | 9.62 | 258 | 87959 | 94558 | 46503287 |
| Bezoar | 15.26 | 9.62 | 16 | 88201 | 1403 | 46596442 |
| Neuroendocrine tumour | 15.21 | 9.62 | 11 | 88206 | 584 | 46597261 |
| Intestinal perforation | 15.08 | 9.62 | 50 | 88167 | 10801 | 46587044 |
| Febrile bone marrow aplasia | 14.77 | 9.62 | 37 | 88180 | 6825 | 46591020 |
| Thirst | 14.74 | 9.62 | 50 | 88167 | 10926 | 46586919 |
| Granulocytopenia neonatal | 14.69 | 9.62 | 4 | 88213 | 16 | 46597829 |
| Ileus paralytic | 14.66 | 9.62 | 28 | 88189 | 4295 | 46593550 |
| Injection site warmth | 14.54 | 9.62 | 4 | 88213 | 13768 | 46584077 |
| Porphyria acute | 14.43 | 9.62 | 9 | 88208 | 373 | 46597472 |
| Blood pressure systolic increased | 14.39 | 9.62 | 20 | 88197 | 28767 | 46569078 |
| Aspiration | 14.22 | 9.62 | 45 | 88172 | 9486 | 46588359 |
| Muscle contracture | 14.15 | 9.62 | 15 | 88202 | 1332 | 46596513 |
| Cholelithiasis | 14.12 | 9.62 | 123 | 88094 | 38558 | 46559287 |
| Vagus nerve disorder | 14.08 | 9.62 | 6 | 88211 | 110 | 46597735 |
| Adverse event | 14.05 | 9.62 | 27 | 88190 | 34157 | 46563688 |
| Pericarditis | 13.67 | 9.62 | 15 | 88202 | 23912 | 46573933 |
| Leukoencephalopathy | 13.66 | 9.62 | 26 | 88191 | 3978 | 46593867 |
| Feeling abnormal | 13.56 | 9.62 | 161 | 88056 | 124899 | 46472946 |
| Infusion related reaction | 13.54 | 9.62 | 124 | 88093 | 101084 | 46496761 |
| Vascular encephalopathy | 13.53 | 9.62 | 9 | 88208 | 417 | 46597428 |
| Drug resistance | 13.53 | 9.62 | 8 | 88209 | 17360 | 46580485 |
| Intestinal obstruction | 13.50 | 9.62 | 90 | 88127 | 25985 | 46571860 |
| Pulmonary air leakage | 13.50 | 9.62 | 4 | 88213 | 23 | 46597822 |
| Pneumonitis | 13.48 | 9.62 | 96 | 88121 | 28324 | 46569521 |
| Wound | 13.44 | 9.62 | 39 | 88178 | 42763 | 46555082 |
| Hyperpyrexia | 13.43 | 9.62 | 21 | 88196 | 2745 | 46595100 |
| Porphyria | 13.42 | 9.62 | 6 | 88211 | 124 | 46597721 |
| Autonomic neuropathy | 13.42 | 9.62 | 11 | 88206 | 704 | 46597141 |
| Therapy non-responder | 13.29 | 9.62 | 37 | 88180 | 41115 | 46556730 |
| Hypotension | 13.15 | 9.62 | 551 | 87666 | 232038 | 46365807 |
| Congenital musculoskeletal anomaly | 13.14 | 9.62 | 9 | 88208 | 438 | 46597407 |
| Patent ductus arteriosus | 13.08 | 9.62 | 25 | 88192 | 3837 | 46594008 |
| Drug clearance decreased | 13.07 | 9.62 | 13 | 88204 | 1071 | 46596774 |
| Premature baby | 12.92 | 9.62 | 68 | 88149 | 18044 | 46579801 |
| Foetal malpresentation | 12.89 | 9.62 | 5 | 88212 | 71 | 46597774 |
| Red blood cell spherocytes present | 12.89 | 9.62 | 3 | 88214 | 5 | 46597840 |
| Gaze palsy | 12.84 | 9.62 | 14 | 88203 | 1284 | 46596561 |
| Loss of personal independence in daily activities | 12.77 | 9.62 | 60 | 88157 | 57123 | 46540722 |
| Anaphylactic reaction | 12.75 | 9.62 | 155 | 88062 | 52957 | 46544888 |
| Suicide attempt | 12.73 | 9.62 | 57 | 88160 | 54979 | 46542866 |
| Stridor | 12.73 | 9.62 | 22 | 88195 | 3125 | 46594720 |
| Oesophageal ulcer | 12.64 | 9.62 | 25 | 88192 | 3936 | 46593909 |
| Urosepsis | 12.62 | 9.62 | 60 | 88157 | 15293 | 46582552 |
| Ventricular fibrillation | 12.59 | 9.62 | 49 | 88168 | 11447 | 46586398 |
| Intercepted product administration error | 12.47 | 9.62 | 5 | 88212 | 78 | 46597767 |
| Sinus disorder | 12.39 | 9.62 | 8 | 88209 | 16555 | 46581290 |
| Economic problem | 12.21 | 9.62 | 17 | 88200 | 2003 | 46595842 |
| Head titubation | 12.19 | 9.62 | 10 | 88207 | 641 | 46597204 |
| Joint injury | 12.17 | 9.62 | 11 | 88206 | 19198 | 46578647 |
| Toxicity to various agents | 12.11 | 9.62 | 306 | 87911 | 211460 | 46386385 |
| Multiple sclerosis relapse | 12.08 | 9.62 | 40 | 88177 | 42085 | 46555760 |
| Granulomatous liver disease | 12.04 | 9.62 | 11 | 88206 | 815 | 46597030 |
| Reflux gastritis | 12.03 | 9.62 | 11 | 88206 | 816 | 46597029 |
| Balance disorder | 12.01 | 9.62 | 72 | 88145 | 64449 | 46533396 |
| Neoplasm progression | 12.00 | 9.62 | 89 | 88128 | 26594 | 46571251 |
| Vascular pain | 11.96 | 9.62 | 10 | 88207 | 658 | 46597187 |
| Generalised tonic-clonic seizure | 11.94 | 9.62 | 90 | 88127 | 27032 | 46570813 |
| Hypersensitivity | 11.90 | 9.62 | 206 | 88011 | 150115 | 46447730 |
| Abdominal tenderness | 11.90 | 9.62 | 35 | 88182 | 7093 | 46590752 |
| Tooth disorder | 11.84 | 9.62 | 16 | 88201 | 23287 | 46574558 |
| Gastrointestinal necrosis | 11.79 | 9.62 | 20 | 88197 | 2798 | 46595047 |
| Hypoalbuminaemia | 11.78 | 9.62 | 44 | 88173 | 10083 | 46587762 |
| Throat irritation | 11.73 | 9.62 | 23 | 88194 | 28878 | 46568967 |
| Nasal congestion | 11.64 | 9.62 | 49 | 88168 | 48064 | 46549781 |
| Cystitis noninfective | 11.63 | 9.62 | 11 | 88206 | 852 | 46596993 |
| Blood bilirubin increased | 11.61 | 9.62 | 107 | 88110 | 34077 | 46563768 |
| Hydronephrosis | 11.54 | 9.62 | 39 | 88178 | 8506 | 46589339 |
| Eye pain | 11.54 | 9.62 | 22 | 88195 | 27918 | 46569927 |
| Joint stiffness | 11.50 | 9.62 | 21 | 88196 | 27087 | 46570758 |
| Deep vein thrombosis | 11.41 | 9.62 | 213 | 88004 | 79560 | 46518285 |
| Eructation | 11.40 | 9.62 | 35 | 88182 | 7260 | 46590585 |
| Chronic fatigue syndrome | 11.38 | 9.62 | 12 | 88205 | 1059 | 46596786 |
| Naevus haemorrhage | 11.33 | 9.62 | 5 | 88212 | 100 | 46597745 |
| Methaemoglobinaemia | 11.33 | 9.62 | 17 | 88200 | 2145 | 46595700 |
| Lethargy | 11.29 | 9.62 | 147 | 88070 | 51024 | 46546821 |
| Urinary tract infection enterococcal | 11.25 | 9.62 | 18 | 88199 | 2400 | 46595445 |
| Antiphospholipid syndrome | 11.25 | 9.62 | 15 | 88202 | 1697 | 46596148 |
| Fluid retention | 11.14 | 9.62 | 54 | 88163 | 50992 | 46546853 |
| Catatonia | 11.12 | 9.62 | 23 | 88194 | 3739 | 46594106 |
| Hepatic failure | 11.05 | 9.62 | 104 | 88113 | 33312 | 46564533 |
| Device dislocation | 11.05 | 9.62 | 15 | 88202 | 21787 | 46576058 |
| Myoclonus | 11.01 | 9.62 | 55 | 88162 | 14297 | 46583548 |
| Electrocardiogram T wave inversion | 10.99 | 9.62 | 22 | 88195 | 3494 | 46594351 |
| Therapy cessation | 10.97 | 9.62 | 21 | 88196 | 26608 | 46571237 |
| Leukostasis syndrome | 10.92 | 9.62 | 4 | 88213 | 48 | 46597797 |
| Lung infiltration | 10.91 | 9.62 | 54 | 88163 | 13989 | 46583856 |
| Device issue | 10.90 | 9.62 | 13 | 88204 | 19967 | 46577878 |
| Gastrointestinal stoma complication | 10.75 | 9.62 | 14 | 88203 | 1547 | 46596298 |
| Prolactin-producing pituitary tumour | 10.73 | 9.62 | 5 | 88212 | 114 | 46597731 |
| Mouth ulceration | 10.69 | 9.62 | 87 | 88130 | 26745 | 46571100 |
| Sinus arrhythmia | 10.65 | 9.62 | 13 | 88204 | 1347 | 46596498 |
| Incorrect dose administered | 10.64 | 9.62 | 47 | 88170 | 45503 | 46552342 |
| Ocular hyperaemia | 10.56 | 9.62 | 13 | 88204 | 19697 | 46578148 |
| Leukocytosis | 10.50 | 9.62 | 78 | 88139 | 23320 | 46574525 |
| Proctalgia | 10.47 | 9.62 | 26 | 88191 | 4770 | 46593075 |
| Brain oedema | 10.43 | 9.62 | 49 | 88168 | 12429 | 46585416 |
| Opisthotonus | 10.42 | 9.62 | 7 | 88210 | 330 | 46597515 |
| Lip erosion | 10.42 | 9.62 | 10 | 88207 | 789 | 46597056 |
| Foot fracture | 10.41 | 9.62 | 13 | 88204 | 19569 | 46578276 |
| Dyspnoea | 10.39 | 9.62 | 1119 | 87098 | 514429 | 46083416 |
| Nephrocalcinosis | 10.39 | 9.62 | 11 | 88206 | 976 | 46596869 |
| Tracheal injury | 10.37 | 9.62 | 4 | 88213 | 56 | 46597789 |
| Mucosal erosion | 10.36 | 9.62 | 13 | 88204 | 1385 | 46596460 |
| Peritoneal perforation | 10.31 | 9.62 | 5 | 88212 | 125 | 46597720 |
| Alopecia | 10.30 | 9.62 | 231 | 87986 | 162183 | 46435662 |
| Non-cardiac chest pain | 10.29 | 9.62 | 30 | 88187 | 6048 | 46591797 |
| Amylase increased | 10.28 | 9.62 | 28 | 88189 | 5431 | 46592414 |
| Immunodeficiency | 10.26 | 9.62 | 6 | 88211 | 13100 | 46584745 |
| Carpal tunnel syndrome | 10.14 | 9.62 | 9 | 88208 | 15850 | 46581995 |
| Visual impairment | 10.14 | 9.62 | 79 | 88138 | 66610 | 46531235 |
| Blood alkaline phosphatase increased | 10.13 | 9.62 | 117 | 88100 | 39492 | 46558353 |
| Joint effusion | 10.11 | 9.62 | 5 | 88212 | 11990 | 46585855 |
| Metastases to central nervous system | 10.07 | 9.62 | 45 | 88172 | 11176 | 46586669 |
| Injection site urticaria | 10.07 | 9.62 | 5 | 88212 | 11962 | 46585883 |
| Tumour pain | 10.03 | 9.62 | 12 | 88205 | 1217 | 46596628 |
| Bone density decreased | 9.98 | 9.62 | 3 | 88214 | 9749 | 46588096 |
| Computerised tomogram thorax | 9.94 | 9.62 | 4 | 88213 | 63 | 46597782 |
| Urea urine increased | 9.88 | 9.62 | 3 | 88214 | 19 | 46597826 |
| Disease progression | 9.87 | 9.62 | 234 | 87983 | 91066 | 46506779 |
| Hyperemesis gravidarum | 9.85 | 9.62 | 8 | 88209 | 505 | 46597340 |
| Abdominal mass | 9.78 | 9.62 | 17 | 88200 | 2425 | 46595420 |
| Febrile infection | 9.77 | 9.62 | 12 | 88205 | 1251 | 46596594 |
| Infusion site vesicles | 9.76 | 9.62 | 7 | 88210 | 367 | 46597478 |
| Musculoskeletal disorder | 9.73 | 9.62 | 9 | 88208 | 15536 | 46582309 |
| PCO2 decreased | 9.73 | 9.62 | 12 | 88205 | 1256 | 46596589 |
| Sciatica | 9.72 | 9.62 | 13 | 88204 | 19007 | 46578838 |
| Ultrasound abdomen abnormal | 9.71 | 9.62 | 4 | 88213 | 67 | 46597778 |
| Bursitis | 9.71 | 9.62 | 14 | 88203 | 19828 | 46578017 |
| Sopor | 9.69 | 9.62 | 14 | 88203 | 19814 | 46578031 |
| Calcium deficiency | 9.67 | 9.62 | 10 | 88207 | 863 | 46596982 |
FDA Adverse Event Reporting System (Male)
| MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
|---|---|---|---|---|---|---|
| Febrile neutropenia | 252.57 | 10.28 | 578 | 53299 | 106115 | 29792486 |
| Vomiting | 252.34 | 10.28 | 917 | 52960 | 218901 | 29679700 |
| Nausea | 198.37 | 10.28 | 1053 | 52824 | 295904 | 29602697 |
| Drug ineffective | 186.73 | 10.28 | 203 | 53674 | 340184 | 29558417 |
| General physical health deterioration | 98.53 | 10.28 | 398 | 53479 | 99546 | 29799055 |
| Dehydration | 92.36 | 10.28 | 453 | 53424 | 123086 | 29775515 |
| Drug abuse | 85.82 | 10.28 | 21 | 53856 | 82051 | 29816550 |
| Decreased appetite | 74.58 | 10.28 | 493 | 53384 | 149417 | 29749184 |
| Impaired gastric emptying | 65.95 | 10.28 | 51 | 53826 | 3155 | 29895446 |
| Serotonin syndrome | 63.70 | 10.28 | 115 | 53762 | 17776 | 29880825 |
| Constipation | 62.73 | 10.28 | 382 | 53495 | 112524 | 29786077 |
| Pyrexia | 62.32 | 10.28 | 805 | 53072 | 293684 | 29604917 |
| Product dose omission issue | 55.30 | 10.28 | 50 | 53827 | 91581 | 29807020 |
| Malignant neoplasm progression | 51.75 | 10.28 | 262 | 53615 | 72025 | 29826576 |
| Completed suicide | 51.37 | 10.28 | 62 | 53815 | 99430 | 29799171 |
| Neutropenia | 51.28 | 10.28 | 401 | 53476 | 128139 | 29770462 |
| Neutropenic sepsis | 50.77 | 10.28 | 81 | 53796 | 11328 | 29887273 |
| Dystonia | 48.80 | 10.28 | 73 | 53804 | 9654 | 29888947 |
| Drug intolerance | 39.47 | 10.28 | 16 | 53861 | 45275 | 29853326 |
| Psoriasis | 38.73 | 10.28 | 14 | 53863 | 42492 | 29856109 |
| Thrombocytopenia | 38.43 | 10.28 | 396 | 53481 | 136648 | 29761953 |
| Death | 37.51 | 10.28 | 437 | 53440 | 356846 | 29541755 |
| Sepsis | 36.41 | 10.28 | 413 | 53464 | 145982 | 29752619 |
| Rheumatoid arthritis | 35.17 | 10.28 | 15 | 53862 | 41182 | 29857419 |
| Hyponatraemia | 33.93 | 10.28 | 222 | 53655 | 66980 | 29831621 |
| Toxicity to various agents | 32.71 | 10.28 | 186 | 53691 | 176997 | 29721604 |
| Abdominal pain | 32.07 | 10.28 | 379 | 53498 | 135275 | 29763326 |
| Hypokalaemia | 31.17 | 10.28 | 175 | 53702 | 50017 | 29848584 |
| Therapeutic product effect incomplete | 31.07 | 10.28 | 11 | 53866 | 33823 | 29864778 |
| Neuroleptic malignant syndrome | 30.67 | 10.28 | 81 | 53796 | 16214 | 29882387 |
| Therapeutic product effect decreased | 29.30 | 10.28 | 8 | 53869 | 29068 | 29869533 |
| Hypophagia | 28.96 | 10.28 | 97 | 53780 | 22139 | 29876462 |
| Mesothelioma | 28.93 | 10.28 | 15 | 53862 | 457 | 29898144 |
| Alveolar lung disease | 28.48 | 10.28 | 14 | 53863 | 380 | 29898221 |
| Pneumonitis | 28.32 | 10.28 | 111 | 53766 | 27343 | 29871258 |
| Pulmonary interstitial emphysema syndrome | 28.11 | 10.28 | 14 | 53863 | 391 | 29898210 |
| Treatment failure | 27.48 | 10.28 | 14 | 53863 | 34665 | 29863936 |
| Intentional overdose | 27.02 | 10.28 | 21 | 53856 | 41460 | 29857141 |
| Peripheral swelling | 26.57 | 10.28 | 43 | 53834 | 61031 | 29837570 |
| Arthralgia | 25.88 | 10.28 | 141 | 53736 | 135650 | 29762951 |
| Malnutrition | 25.85 | 10.28 | 61 | 53816 | 11388 | 29887213 |
| Long QT syndrome | 25.62 | 10.28 | 26 | 53851 | 2307 | 29896294 |
| Hepatic failure | 25.47 | 10.28 | 125 | 53752 | 33918 | 29864683 |
| Haematopoietic stem cell mobilisation | 24.68 | 10.28 | 10 | 53867 | 169 | 29898432 |
| Weight increased | 24.67 | 10.28 | 62 | 53815 | 74851 | 29823750 |
| Oesophagitis | 24.66 | 10.28 | 59 | 53818 | 11112 | 29887489 |
| Electrocardiogram QT prolonged | 24.31 | 10.28 | 128 | 53749 | 35707 | 29862894 |
| Gastrointestinal hypermotility | 24.09 | 10.28 | 9 | 53868 | 121 | 29898480 |
| Toxic encephalopathy | 23.71 | 10.28 | 35 | 53842 | 4574 | 29894027 |
| Pleural effusion | 23.14 | 10.28 | 219 | 53658 | 73847 | 29824754 |
| Hyperthermia malignant | 23.05 | 10.28 | 22 | 53855 | 1812 | 29896789 |
| Talipes | 22.79 | 10.28 | 21 | 53856 | 1654 | 29896947 |
| Leukopenia | 22.78 | 10.28 | 176 | 53701 | 55983 | 29842618 |
| Ileus | 22.19 | 10.28 | 70 | 53807 | 15485 | 29883116 |
| Diarrhoea | 22.08 | 10.28 | 770 | 53107 | 333333 | 29565268 |
| Extrapyramidal disorder | 22.03 | 10.28 | 55 | 53822 | 10638 | 29887963 |
| Premature baby | 21.90 | 10.28 | 73 | 53804 | 16618 | 29881983 |
| Congenital pneumonia | 21.80 | 10.28 | 8 | 53869 | 102 | 29898499 |
| Hepatocellular injury | 21.60 | 10.28 | 97 | 53780 | 25374 | 29873227 |
| Ascites | 21.48 | 10.28 | 124 | 53753 | 35797 | 29862804 |
| Joint swelling | 21.42 | 10.28 | 32 | 53845 | 46914 | 29851687 |
| Hiccups | 21.01 | 10.28 | 50 | 53827 | 9384 | 29889217 |
| Myocardial infarction | 20.99 | 10.28 | 136 | 53741 | 125489 | 29773112 |
| Intentional product misuse | 20.79 | 10.28 | 19 | 53858 | 34648 | 29863953 |
| Cardiac failure congestive | 20.62 | 10.28 | 80 | 53797 | 84327 | 29814274 |
| Conjunctival irritation | 20.50 | 10.28 | 8 | 53869 | 122 | 29898479 |
| Enteritis | 20.28 | 10.28 | 40 | 53837 | 6605 | 29891996 |
| Anaemia | 19.87 | 10.28 | 502 | 53375 | 207490 | 29691111 |
| Suicide attempt | 19.85 | 10.28 | 22 | 53855 | 36675 | 29861926 |
| Delirium | 19.75 | 10.28 | 133 | 53744 | 40498 | 29858103 |
| Off label use | 19.60 | 10.28 | 323 | 53554 | 248967 | 29649634 |
| Pneumonia | 19.54 | 10.28 | 760 | 53117 | 333546 | 29565055 |
| Foetal exposure during pregnancy | 19.33 | 10.28 | 123 | 53754 | 36748 | 29861853 |
| Genital erythema | 19.03 | 10.28 | 8 | 53869 | 149 | 29898452 |
| Colitis | 18.82 | 10.28 | 107 | 53770 | 30713 | 29867888 |
| Pseudomonal sepsis | 18.73 | 10.28 | 25 | 53852 | 2975 | 29895626 |
| Electrocardiogram QT shortened | 18.60 | 10.28 | 8 | 53869 | 158 | 29898443 |
| Intentional product use issue | 18.48 | 10.28 | 23 | 53854 | 36417 | 29862184 |
| Cytokine storm | 18.28 | 10.28 | 12 | 53865 | 572 | 29898029 |
| Mucosal inflammation | 18.06 | 10.28 | 105 | 53772 | 30389 | 29868212 |
| Renal vasculitis | 17.80 | 10.28 | 7 | 53870 | 109 | 29898492 |
| Aplastic anaemia | 17.63 | 10.28 | 34 | 53843 | 5522 | 29893079 |
| Septic shock | 17.41 | 10.28 | 183 | 53694 | 63424 | 29835177 |
| Blood pressure fluctuation | 17.29 | 10.28 | 5 | 53872 | 17498 | 29881103 |
| Failure to thrive | 17.20 | 10.28 | 42 | 53835 | 8012 | 29890589 |
| Fall | 16.92 | 10.28 | 228 | 53649 | 181644 | 29716957 |
| Pulmonary embolism | 16.57 | 10.28 | 214 | 53663 | 77921 | 29820680 |
| Lower respiratory tract infection | 16.48 | 10.28 | 93 | 53784 | 26621 | 29871980 |
| Feeling abnormal | 16.42 | 10.28 | 50 | 53827 | 56706 | 29841895 |
| Acute abdomen | 16.36 | 10.28 | 18 | 53859 | 1753 | 29896848 |
| Laryngeal cancer metastatic | 16.31 | 10.28 | 6 | 53871 | 77 | 29898524 |
| Chemotherapeutic drug level increased | 16.21 | 10.28 | 8 | 53869 | 219 | 29898382 |
| Drug resistance | 16.14 | 10.28 | 8 | 53869 | 20125 | 29878476 |
| Tardive dyskinesia | 16.11 | 10.28 | 31 | 53846 | 5026 | 29893575 |
| Rash maculo-papular | 16.02 | 10.28 | 89 | 53788 | 25329 | 29873272 |
| Bacterial tracheitis | 15.97 | 10.28 | 3 | 53874 | 0 | 29898601 |
| Urticaria | 15.88 | 10.28 | 48 | 53829 | 54558 | 29844043 |
| Blood alkaline phosphatase increased | 15.86 | 10.28 | 104 | 53773 | 31383 | 29867218 |
| Condition aggravated | 15.42 | 10.28 | 166 | 53711 | 137700 | 29760901 |
| Subileus | 15.24 | 10.28 | 23 | 53854 | 3064 | 29895537 |
| Product use issue | 15.21 | 10.28 | 38 | 53839 | 45978 | 29852623 |
| Spleen congestion | 14.97 | 10.28 | 9 | 53868 | 367 | 29898234 |
| Ileus paralytic | 14.88 | 10.28 | 32 | 53845 | 5616 | 29892985 |
| Tumour lysis syndrome | 14.86 | 10.28 | 54 | 53823 | 12831 | 29885770 |
| Erectile dysfunction | 14.81 | 10.28 | 7 | 53870 | 18095 | 29880506 |
| Performance status decreased | 14.80 | 10.28 | 26 | 53851 | 3931 | 29894670 |
| Hyperbilirubinaemia | 14.72 | 10.28 | 65 | 53812 | 16877 | 29881724 |
| Psoriatic arthropathy | 14.68 | 10.28 | 5 | 53872 | 15756 | 29882845 |
| Headache | 14.37 | 10.28 | 236 | 53641 | 182070 | 29716531 |
| Product use in unapproved indication | 14.31 | 10.28 | 76 | 53801 | 73617 | 29824984 |
| Diaphragmatic rupture | 14.16 | 10.28 | 4 | 53873 | 20 | 29898581 |
| Aphthous ulcer | 13.95 | 10.28 | 26 | 53851 | 4115 | 29894486 |
| Creatine urine increased | 13.89 | 10.28 | 3 | 53874 | 3 | 29898598 |
| Abdominal compartment syndrome | 13.88 | 10.28 | 12 | 53865 | 869 | 29897732 |
| Diabetic gastroparesis | 13.62 | 10.28 | 6 | 53871 | 126 | 29898475 |
| Rheumatoid nodule | 13.61 | 10.28 | 16 | 53861 | 1674 | 29896927 |
| Drug clearance decreased | 13.55 | 10.28 | 14 | 53863 | 1269 | 29897332 |
| Wrong technique in product usage process | 13.48 | 10.28 | 22 | 53855 | 31133 | 29867468 |
| Asthma | 13.47 | 10.28 | 28 | 53849 | 36146 | 29862455 |
| Maternal drugs affecting foetus | 13.38 | 10.28 | 26 | 53851 | 4247 | 29894354 |
| Diffuse alveolar damage | 13.30 | 10.28 | 17 | 53860 | 1939 | 29896662 |
| Hypoalbuminaemia | 13.23 | 10.28 | 47 | 53830 | 11045 | 29887556 |
| Gait disturbance | 12.97 | 10.28 | 80 | 53797 | 74697 | 29823904 |
| Product quality issue | 12.87 | 10.28 | 9 | 53868 | 18765 | 29879836 |
| Dyschezia | 12.87 | 10.28 | 13 | 53864 | 1147 | 29897454 |
| Chills | 12.85 | 10.28 | 192 | 53685 | 72146 | 29826455 |
| Impetigo | 12.75 | 10.28 | 11 | 53866 | 794 | 29897807 |
| Intestinal ischaemia | 12.69 | 10.28 | 34 | 53843 | 6863 | 29891738 |
| Blood aluminium increased | 12.68 | 10.28 | 3 | 53874 | 6 | 29898595 |
| Pericardial effusion | 12.64 | 10.28 | 73 | 53804 | 21071 | 29877530 |
| Type III immune complex mediated reaction | 12.61 | 10.28 | 7 | 53870 | 245 | 29898356 |
| Tumour pain | 12.57 | 10.28 | 12 | 53865 | 988 | 29897613 |
| Injection site pain | 12.56 | 10.28 | 22 | 53855 | 30288 | 29868313 |
| Blood creatine phosphokinase increased | 12.42 | 10.28 | 39 | 53838 | 43809 | 29854792 |
| Device related infection | 12.38 | 10.28 | 62 | 53815 | 16953 | 29881648 |
| Hepatitis fulminant | 12.36 | 10.28 | 24 | 53853 | 3917 | 29894684 |
| Renal dysplasia | 12.34 | 10.28 | 6 | 53871 | 159 | 29898442 |
| Small intestinal obstruction | 12.32 | 10.28 | 53 | 53824 | 13606 | 29884995 |
| Dysphagia | 12.32 | 10.28 | 156 | 53721 | 56542 | 29842059 |
| Neutropenic infection | 12.27 | 10.28 | 12 | 53865 | 1018 | 29897583 |
| Disturbance in attention | 12.26 | 10.28 | 13 | 53864 | 22116 | 29876485 |
| Toxic epidermal necrolysis | 12.10 | 10.28 | 64 | 53813 | 17876 | 29880725 |
| Laparotomy | 12.00 | 10.28 | 7 | 53870 | 270 | 29898331 |
| Hygroma colli | 11.86 | 10.28 | 4 | 53873 | 39 | 29898562 |
| Cytokine release syndrome | 11.77 | 10.28 | 42 | 53835 | 9891 | 29888710 |
| Lactic acidosis | 11.76 | 10.28 | 24 | 53853 | 31189 | 29867412 |
| Arthropathy | 11.69 | 10.28 | 12 | 53865 | 20715 | 29877886 |
| Porphyria acute | 11.48 | 10.28 | 5 | 53872 | 102 | 29898499 |
| Immune-mediated hepatitis | 11.47 | 10.28 | 12 | 53865 | 1104 | 29897497 |
| Pulmonary sepsis | 11.40 | 10.28 | 16 | 53861 | 1997 | 29896604 |
| Gastrointestinal malformation | 11.27 | 10.28 | 4 | 53873 | 46 | 29898555 |
| Meconium abnormal | 11.16 | 10.28 | 3 | 53874 | 12 | 29898589 |
| Underdose | 11.05 | 10.28 | 4 | 53873 | 12137 | 29886464 |
| Hypoaesthesia | 11.05 | 10.28 | 55 | 53822 | 54175 | 29844426 |
| Skeletal dysplasia | 10.93 | 10.28 | 5 | 53872 | 115 | 29898486 |
| Heart rate decreased | 10.91 | 10.28 | 13 | 53864 | 20981 | 29877620 |
| Bradycardia | 10.90 | 10.28 | 71 | 53806 | 65455 | 29833146 |
| Spinal cord injury thoracic | 10.85 | 10.28 | 5 | 53872 | 117 | 29898484 |
| Non-small cell lung cancer | 10.84 | 10.28 | 22 | 53855 | 3708 | 29894893 |
| Hospitalisation | 10.82 | 10.28 | 42 | 53835 | 44277 | 29854324 |
| Calcium ionised increased | 10.79 | 10.28 | 3 | 53874 | 14 | 29898587 |
| Nasopharyngitis | 10.71 | 10.28 | 62 | 53815 | 58787 | 29839814 |
| Pain in extremity | 10.66 | 10.28 | 137 | 53740 | 110084 | 29788517 |
| Congenital nasal septum deviation | 10.62 | 10.28 | 3 | 53874 | 15 | 29898586 |
| Lenticulostriatal vasculopathy | 10.62 | 10.28 | 3 | 53874 | 15 | 29898586 |
| Cachexia | 10.60 | 10.28 | 31 | 53846 | 6580 | 29892021 |
| Sports injury | 10.33 | 10.28 | 5 | 53872 | 131 | 29898470 |
Pharmacologic Action:
| Source | Code | Description |
|---|---|---|
| ATC | A03FA01 | ALIMENTARY TRACT AND METABOLISM DRUGS FOR FUNCTIONAL GASTROINTESTINAL DISORDERS PROPULSIVES Propulsives |
| FDA MoA | N0000175799 | Dopamine D2 Antagonists |
| FDA EPC | N0000175800 | Dopamine-2 Receptor Antagonist |
| MeSH PA | D000932 | Antiemetics |
| MeSH PA | D002491 | Central Nervous System Agents |
| MeSH PA | D015259 | Dopamine Agents |
| MeSH PA | D018492 | Dopamine Antagonists |
| MeSH PA | D065127 | Dopamine D2 Receptor Antagonists |
| MeSH PA | D005765 | Gastrointestinal Agents |
| MeSH PA | D018377 | Neurotransmitter Agents |
| MeSH PA | D018373 | Peripheral Nervous System Agents |
| CHEBI has role | CHEBI:35703 | xenobiotic |
| CHEBI has role | CHEBI:48561 | dopamine blocker |
| CHEBI has role | CHEBI:50919 | antiemetico |
| CHEBI has role | CHEBI:55324 | gastrointestinal agents |
| CHEBI has role | CHEBI:78298 | environmental contaminants |
Drug Use (View source of the data)
| Disease | Relation | SNOMED_ID | DOID |
|---|---|---|---|
| Diabetic gastroparesis | indication | 34140002 | |
| Intubation of gastrointestinal tract | indication | 235419001 | |
| Gastroesophageal reflux disease | indication | 235595009 | DOID:8534 |
| Chemotherapy-induced nausea and vomiting | indication | 236084000 | |
| Prevention of Post-Operative Nausea and Vomiting | indication | ||
| Gastrointestinal Radiography Adjunct | indication | ||
| Suicidal thoughts | contraindication | 6471006 | |
| Neuroleptic malignant syndrome | contraindication | 15244003 | DOID:14464 |
| Cirrhosis of liver | contraindication | 19943007 | DOID:5082 |
| Parkinsonism | contraindication | 32798002 | |
| Depressive disorder | contraindication | 35489007 | |
| Hypertensive disorder | contraindication | 38341003 | DOID:10763 |
| Body fluid retention | contraindication | 43498006 | |
| Mechanical ileus | contraindication | 46420000 | |
| Chronic heart failure | contraindication | 48447003 | |
| Gastrointestinal perforation | contraindication | 51875005 | |
| Gastrointestinal hemorrhage | contraindication | 74474003 | |
| Tardive dyskinesia | contraindication | 102449007 | |
| Deficiency of cytochrome-b>5< reductase | contraindication | 124184009 | |
| Seizure disorder | contraindication | 128613002 | |
| Impaired renal function disorder | contraindication | 197663003 | |
| Anastomosis of intestine | contraindication | 235407009 | |
| Pheochromocytoma | contraindication | 302835009 | |
| Porphyria | contraindication | 418470004 | |
| Acquired torsion dystonia | contraindication | 433493000 |
Acid dissociation constants calculated using MoKa v3.0.0
| Dissociation level | Dissociation constant | Type (acidic/basic) |
|---|---|---|
| pKa1 | 13.17 | acidic |
| pKa2 | 8.94 | Basic |
| pKa3 | 1.08 | Basic |
Orange Book patent data (new drug applications)
None
Orange Book exclusivity data (new drug applications)
None
Bioactivity Summary:
| Target | Class | Pharos | UniProt | Action | Type | Activity value (-log[M]) | Mechanism action | Bioact source | MoA source |
|---|---|---|---|---|---|---|---|---|---|
| D(2) dopamine receptor | GPCR | ANTAGONIST | Ki | 7.19 | WOMBAT-PK | CHEMBL | |||
| 5-hydroxytryptamine receptor 3A | Ion channel | ANTAGONIST | Ki | 6.70 | WOMBAT-PK | CHEMBL | |||
| 5-hydroxytryptamine receptor 4 | GPCR | AGONIST | EC50 | 6 | WOMBAT-PK | CHEMBL | |||
| 5-hydroxytryptamine receptor 2B | GPCR | Ki | 6.40 | DRUG MATRIX | |||||
| 5-hydroxytryptamine receptor 2C | GPCR | Ki | 5.90 | DRUG MATRIX | |||||
| Cytochrome P450 2D6 | Enzyme | IC50 | 6.10 | DRUG MATRIX | |||||
| Solute carrier family 22 member 1 | Transporter | IC50 | 4.02 | CHEMBL | |||||
| Aldehyde oxidase | Enzyme | IC50 | 4.51 | WOMBAT-PK | |||||
| Muscarinic acetylcholine receptor M1 | GPCR | WOMBAT-PK | |||||||
| D(3) dopamine receptor | GPCR | Ki | 7.66 | WOMBAT-PK | |||||
| Serotonin 3 (5-HT3) receptor | Ion channel | Kd | 7.30 | CHEMBL | |||||
| Alpha-2A adrenergic receptor | GPCR | Ki | 5.99 | DRUG MATRIX | |||||
| 5-hydroxytryptamine receptor 2A | GPCR | Ki | 5.98 | DRUG MATRIX | |||||
| Serotonin 2 (5-HT2) receptor | GPCR | IC50 | 4.88 | CHEMBL | |||||
| Serotonin 3 receptor (5HT3) | Ion channel | Ki | 6.70 | CHEMBL | |||||
| Adrenergic receptor alpha-2 | GPCR | IC50 | 5.11 | CHEMBL | |||||
| Serotonin 1 (5-HT1) receptor | GPCR | IC50 | 5.11 | CHEMBL | |||||
| D(2) dopamine receptor | GPCR | Ki | 6.98 | CHEMBL | |||||
| Serotonin 3 (5-HT3) receptor | Ion channel | Ki | 6.68 | CHEMBL | |||||
| Adrenergic receptor alpha-1 | GPCR | IC50 | 4.48 | CHEMBL | |||||
| D(2) dopamine receptor | GPCR | Ki | 7.10 | CHEMBL | |||||
| D(3) dopamine receptor | GPCR | IC50 | 7.21 | CHEMBL | |||||
| 5-hydroxytryptamine receptor 4 | GPCR | Ki | 6.05 | CHEMBL | |||||
| 5-hydroxytryptamine receptor 4 | GPCR | Ki | 6.26 | CHEMBL | |||||
| D(2) dopamine receptor | GPCR | ANTAGONIST | Ki | 7.54 | IUPHAR | ||||
| 5-hydroxytryptamine receptor 4 | Unclassified | AGONIST | Ki | 6 | IUPHAR |
External reference:
| ID | Source |
|---|---|
| 4019835 | VUID |
| N0000147923 | NUI |
| D00726 | KEGG_DRUG |
| 54143-57-6 | SECONDARY_CAS_RN |
| 4017905 | VANDF |
| 4019835 | VANDF |
| C0025853 | UMLSCUI |
| CHEBI:107736 | CHEBI |
| CHEMBL1200940 | ChEMBL_ID |
| CHEMBL1256771 | ChEMBL_ID |
| CHEMBL86 | ChEMBL_ID |
| 441347 | PUBCHEM_CID |
| D008787 | MESH_DESCRIPTOR_UI |
| DB01233 | DRUGBANK_ID |
| 241 | IUPHAR_LIGAND_ID |
| 1740 | INN_ID |
| L4YEB44I46 | UNII |
| 267036 | RXNORM |
| 1062 | MMSL |
| 5099 | MMSL |
| d00298 | MMSL |
| 001877 | NDDF |
| 004778 | NDDF |
| 31147000 | SNOMEDCT_US |
| 372776000 | SNOMEDCT_US |
| 56549003 | SNOMEDCT_US |
Pharmaceutical products:
| Product | Category | Ingredients | NDC | Form | Quantity | Route | Marketing | Label |
|---|---|---|---|---|---|---|---|---|
| Metoclopramide | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0093-2203 | TABLET | 10 mg | ORAL | ANDA | 27 sections |
| Metoclopramide | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0093-2204 | TABLET | 5 mg | ORAL | ANDA | 27 sections |
| Metoclopramide Hydrochloride | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0115-1651 | TABLET | 10 mg | ORAL | ANDA | 22 sections |
| Metoclopramide Hydrochloride | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0115-1652 | TABLET | 5 mg | ORAL | ANDA | 22 sections |
| Metoclopramide | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0121-0576 | SOLUTION | 5 mg | ORAL | ANDA | 28 sections |
| Metoclopramide | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0121-1576 | SOLUTION | 5 mg | ORAL | ANDA | 28 sections |
| Metoclopramide | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0409-3414 | INJECTION, SOLUTION | 5 mg | INTRAMUSCULAR | ANDA | 15 sections |
| Metoclopramide | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0440-1771 | TABLET | 10 mg | ORAL | ANDA | 22 sections |
| Metoclopramide | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0615-7698 | TABLET | 5 mg | ORAL | ANDA | 27 sections |
| Metoclopramide | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0615-8285 | TABLET | 10 mg | ORAL | ANDA | 27 sections |
| Metoclopramide | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0703-4502 | INJECTION, SOLUTION | 5 mg | INTRAMUSCULAR | ANDA | 23 sections |
| Metoclopramide | HUMAN PRESCRIPTION DRUG LABEL | 1 | 12634-112 | TABLET | 10 mg | ORAL | ANDA | 22 sections |
| METOCLOPRAMIDE | HUMAN PRESCRIPTION DRUG LABEL | 1 | 16590-150 | TABLET | 5 mg | ORAL | ANDA | 25 sections |
| METOCLOPRAMIDE | HUMAN PRESCRIPTION DRUG LABEL | 1 | 16590-151 | TABLET | 10 mg | ORAL | ANDA | 25 sections |
| REGLAN | HUMAN PRESCRIPTION DRUG LABEL | 1 | 16590-906 | TABLET | 10 mg | ORAL | NDA | 24 sections |
| Metoclopramide | HUMAN PRESCRIPTION DRUG LABEL | 1 | 17856-0576 | SOLUTION | 5 mg | ORAL | ANDA | 24 sections |
| Metoclopramide | HUMAN PRESCRIPTION DRUG LABEL | 1 | 21695-346 | TABLET | 10 mg | ORAL | ANDA | 19 sections |
| Metoclopramide | HUMAN PRESCRIPTION DRUG LABEL | 1 | 21695-485 | TABLET | 5 mg | ORAL | ANDA | 19 sections |
| Metoclopramide | HUMAN PRESCRIPTION DRUG LABEL | 1 | 23155-240 | INJECTION | 5 mg | INTRAMUSCULAR | ANDA | 21 sections |
| Metoclopramide | HUMAN PRESCRIPTION DRUG LABEL | 1 | 33261-166 | TABLET | 10 mg | ORAL | ANDA | 22 sections |
| METOCLOPRAMIDE hydrochloride | HUMAN PRESCRIPTION DRUG LABEL | 1 | 40032-580 | TABLET, ORALLY DISINTEGRATING | 10 mg | ORAL | ANDA | 25 sections |
| METOCLOPRAMIDE hydrochloride | HUMAN PRESCRIPTION DRUG LABEL | 1 | 40032-581 | TABLET, ORALLY DISINTEGRATING | 5 mg | ORAL | ANDA | 25 sections |
| Metoclopramide Hydrochloride | HUMAN PRESCRIPTION DRUG LABEL | 1 | 42254-196 | TABLET | 5 mg | ORAL | ANDA | 22 sections |
| Metoclopramide Hydrochloride | HUMAN PRESCRIPTION DRUG LABEL | 1 | 42254-266 | TABLET | 10 mg | ORAL | ANDA | 22 sections |
| Metoclopramide | HUMAN PRESCRIPTION DRUG LABEL | 1 | 42291-595 | TABLET | 5 mg | ORAL | ANDA | 27 sections |
| Metoclopramide | HUMAN PRESCRIPTION DRUG LABEL | 1 | 42291-596 | TABLET | 10 mg | ORAL | ANDA | 27 sections |
| Metoclopramide | HUMAN PRESCRIPTION DRUG LABEL | 1 | 43353-274 | TABLET | 10 mg | ORAL | ANDA | 22 sections |
| Metoclopramide Hydrochloride | HUMAN PRESCRIPTION DRUG LABEL | 1 | 43353-808 | TABLET | 10 mg | ORAL | ANDA | 22 sections |
| METOCLOPRAMIDE hydrochloride | HUMAN PRESCRIPTION DRUG LABEL | 1 | 43386-580 | TABLET, ORALLY DISINTEGRATING | 10 mg | ORAL | ANDA | 24 sections |
| METOCLOPRAMIDE hydrochloride | HUMAN PRESCRIPTION DRUG LABEL | 1 | 43386-581 | TABLET, ORALLY DISINTEGRATING | 5 mg | ORAL | ANDA | 24 sections |