metoclopramide Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
sulpiride derivatives 1782 364-62-5

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • metoclopramide
  • metoclopramide hydrochloride
  • metochlopramide
  • methochlopramide
  • metoclopramide hydrochloride hydrate
  • metoclopramide monohydrochloride
  • metoclopramide HCl
  • AHR-3070-C
  • metaclopramide
A dopamine D2 antagonist that is used as an antiemetic.
  • Molecular weight: 299.80
  • Formula: C14H22ClN3O2
  • CLOGP: 2.23
  • LIPINSKI: 0
  • HAC: 5
  • HDO: 2
  • TPSA: 67.59
  • ALOGS: -2.99
  • ROTB: 7

  • Status: OFP

  • Legend:
    OFP - off patent
    OFM - off market
    ONP - on patent

Drug dosage:

DoseUnitRoute
30 mg O
30 mg P
30 mg R

ADMET properties:

PropertyValueReference
MRTD (Maximum Recommended Therapeutic Daily Dose) 33.36 ┬ÁM/kg/day Contrera JF, Matthews EJ, Kruhlak NL, Benz RD
BDDCS (Biopharmaceutical Drug Disposition Classification System) 1 Hosey CM, Chan R, Benet LZ
S (Water solubility) 0.20 mg/mL Hosey CM, Chan R, Benet LZ
EoM (Fraction excreted unchanged in urine) 20 % Hosey CM, Chan R, Benet LZ
BA (Bioavailability) 76 % Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H
Vd (Volume of distribution) 3.20 L/kg Lombardo F, Berellini G, Obach RS
CL (Clearance) 5.70 mL/min/kg Lombardo F, Berellini G, Obach RS
fu (Fraction unbound in plasma) 0.60 % Lombardo F, Berellini G, Obach RS
t_half (Half-life) 7.20 hours Lombardo F, Berellini G, Obach RS

Approvals:

DateAgencyCompanyOrphan
Feb. 7, 1979 FDA BAXTER HLTHCARE CORP

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Drug ineffective 401.29 9.62 416 87801 677422 45920423
Vomiting 348.76 9.62 1731 86486 451063 46146782
Rheumatoid arthritis 315.30 9.62 41 88176 240174 46357671
Febrile neutropenia 252.11 9.62 554 87663 94073 46503772
Nausea 215.85 9.62 2109 86108 685345 45912500
Drug intolerance 126.16 9.62 60 88157 146989 46450856
Joint swelling 126.15 9.62 79 88138 165994 46431851
General physical health deterioration 117.13 9.62 481 87736 115288 46482557
Impaired gastric emptying 112.87 9.62 105 88112 7967 46589878
Injection site pain 111.60 9.62 32 88185 107120 46490725
Dystonia 110.68 9.62 121 88096 11136 46586709
Pyrexia 110.49 9.62 1074 87143 347728 46250117
Completed suicide 108.64 9.62 71 88146 145849 46451996
Arthralgia 106.71 9.62 344 87873 364259 46233586
Dehydration 100.79 9.62 579 87638 158961 46438884
Contraindicated product administered 94.87 9.62 18 88199 79929 46517916
Hypokalaemia 94.81 9.62 373 87844 87651 46510194
Product dose omission issue 91.76 9.62 110 88107 168410 46429435
Tardive dyskinesia 90.14 9.62 90 88127 7453 46590392
Therapeutic product effect decreased 87.24 9.62 24 88193 82577 46515268
Weight increased 82.67 9.62 114 88103 164359 46433486
Serotonin syndrome 76.28 9.62 152 88065 24068 46573777
Psoriasis 73.89 9.62 28 88189 78576 46519269
Neutropenia 73.62 9.62 493 87724 142711 46455134
Toxic epidermal necrolysis 72.81 9.62 142 88075 22136 46575709
Treatment failure 72.42 9.62 43 88174 93044 46504801
Synovitis 71.93 9.62 14 88203 61061 46536784
Abdominal pain 70.07 9.62 703 87514 229328 46368517
Neutropenic sepsis 69.05 9.62 100 88117 12224 46585621
Arthropathy 67.49 9.62 38 88179 84662 46513183
Constipation 67.18 9.62 560 87657 173537 46424308
Therapeutic product effect incomplete 66.82 9.62 32 88185 78121 46519724
Atelectasis 65.38 9.62 123 88094 18667 46579178
Phaeochromocytoma crisis 65.03 9.62 21 88196 167 46597678
Malignant neoplasm progression 65.00 9.62 269 87948 64657 46533188
Sinusitis 64.14 9.62 91 88126 129677 46468168
Decreased appetite 62.72 9.62 600 87617 193236 46404609
Cholecystitis chronic 60.00 9.62 86 88131 10413 46587432
Extrapyramidal disorder 59.62 9.62 89 88128 11179 46586666
Hyponatraemia 56.41 9.62 356 87861 100976 46496869
Swelling 56.07 9.62 93 88124 124418 46473427
Torsade de pointes 55.91 9.62 90 88127 12064 46585781
Thrombocytopenia 52.49 9.62 414 87803 126167 46471678
Nasopharyngitis 51.68 9.62 136 88081 153862 46443983
Electrocardiogram QT prolonged 50.85 9.62 212 88005 51113 46546732
Hand deformity 50.18 9.62 4 88213 34570 46563275
Gastritis 49.24 9.62 160 88057 34218 46563627
Mucosal inflammation 48.45 9.62 173 88044 38803 46559042
Renal ischaemia 47.26 9.62 23 88194 580 46597265
Product use issue 47.12 9.62 66 88151 94578 46503267
Pain 46.81 9.62 628 87589 476320 46121525
Abdominal discomfort 45.93 9.62 140 88077 151025 46446820
Hypomagnesaemia 44.96 9.62 117 88100 22093 46575752
Injection site bruising 44.51 9.62 7 88210 35629 46562216
Peripheral swelling 44.13 9.62 152 88065 157919 46439926
Computerised tomogram thorax abnormal 43.84 9.62 29 88188 1332 46596513
Subileus 43.80 9.62 40 88177 2963 46594882
Psoriatic arthropathy 43.56 9.62 8 88209 36371 46561474
Injection site erythema 43.28 9.62 46 88171 74381 46523464
Diabetes insipidus 41.97 9.62 34 88183 2140 46595705
Pulmonary embolism 39.57 9.62 345 87872 108240 46489605
Restlessness 39.48 9.62 122 88095 25402 46572443
Ileus 39.27 9.62 84 88133 13980 46583865
PO2 increased 38.85 9.62 23 88194 867 46596978
Duodenal stenosis 38.79 9.62 20 88197 572 46597273
PCO2 increased 38.65 9.62 26 88191 1228 46596617
Device expulsion 37.79 9.62 4 88213 27538 46570307
Electrolyte imbalance 37.20 9.62 93 88124 17133 46580712
Anaemia 36.74 9.62 683 87534 255096 46342749
Arthritis 36.44 9.62 56 88161 77260 46520585
Acute kidney injury 36.41 9.62 637 87580 235218 46362627
Fall 36.08 9.62 423 87794 328674 46269171
Systemic lupus erythematosus 36.02 9.62 42 88175 65138 46532707
Injection site pruritus 35.96 9.62 15 88202 39728 46558117
Hypoxia 35.90 9.62 193 88024 51645 46546200
Blood bicarbonate decreased 35.54 9.62 35 88182 2850 46594995
Diarrhoea 35.48 9.62 1341 86876 558261 46039584
Injection site swelling 35.25 9.62 16 88201 40311 46557534
Dyskinesia 34.76 9.62 127 88090 28798 46569047
Wrong technique in product usage process 34.69 9.62 31 88186 54391 46543454
Akathisia 33.96 9.62 56 88161 7658 46590187
Stevens-Johnson syndrome 33.87 9.62 109 88108 23188 46574657
Musculoskeletal stiffness 33.27 9.62 86 88131 97907 46499938
Abortion spontaneous 32.77 9.62 21 88196 43625 46554220
Glossodynia 32.43 9.62 22 88195 44351 46553494
Gastroenteritis 32.26 9.62 110 88107 24109 46573736
Oculogyric crisis 32.00 9.62 23 88194 1210 46596635
Injection site reaction 30.81 9.62 27 88190 47822 46550023
Left ventricular dysfunction 30.67 9.62 63 88154 10192 46587653
Encephalopathy 30.39 9.62 135 88082 33454 46564391
Pleural effusion 29.92 9.62 263 87954 82689 46515156
Cytokine release syndrome 29.89 9.62 47 88170 6176 46591669
Sepsis 29.75 9.62 390 87827 135624 46462221
Infusion site streaking 29.28 9.62 14 88203 339 46597506
Cholecystitis 29.06 9.62 76 88141 14390 46583455
Blood pressure increased 28.86 9.62 132 88085 126534 46471311
Phaeochromocytoma 28.35 9.62 15 88202 453 46597392
Hyperprolactinaemia 27.92 9.62 31 88186 2901 46594944
Antinuclear antibody negative 27.76 9.62 12 88205 228 46597617
Hepatocellular injury 27.73 9.62 120 88097 29402 46568443
Cataract 27.61 9.62 27 88190 45388 46552457
Influenza 27.58 9.62 82 88135 89188 46508657
Leukopenia 27.47 9.62 222 87995 68121 46529724
Septic shock 27.16 9.62 195 88022 57698 46540147
Tachycardia 26.74 9.62 297 87920 99325 46498520
Herpes simplex reactivation 26.03 9.62 13 88204 347 46597498
Neutrophil count decreased 25.67 9.62 155 88062 43271 46554574
Respiratory dyskinesia 25.51 9.62 7 88210 29 46597816
Blood pH decreased 25.41 9.62 28 88189 2599 46595246
Immune effector cell-associated neurotoxicity syndrome 25.34 9.62 16 88201 678 46597167
Coombs positive haemolytic anaemia 25.05 9.62 13 88204 377 46597468
Confusional state 24.70 9.62 432 87785 159460 46438385
Malnutrition 24.57 9.62 70 88147 13933 46583912
Rash maculo-papular 24.44 9.62 111 88106 27763 46570082
Gastritis haemorrhagic 24.05 9.62 20 88197 1306 46596539
Respiratory syncytial virus infection 23.89 9.62 37 88180 4798 46593047
Small intestinal obstruction 23.81 9.62 76 88141 16096 46581749
Osteoarthritis 23.79 9.62 51 88166 61974 46535871
No adverse event 23.67 9.62 18 88199 34213 46563632
Therapeutic response decreased 23.62 9.62 28 88189 43117 46554728
Erysipelas 23.61 9.62 45 88172 6893 46590952
Mixed liver injury 22.93 9.62 29 88188 3114 46594731
Gelastic seizure 22.91 9.62 5 88212 5 46597840
Aplastic anaemia 22.65 9.62 45 88172 7108 46590737
Accidental exposure to product 22.48 9.62 6 88211 21075 46576770
Excessive eye blinking 22.43 9.62 14 88203 581 46597264
Hyponatraemic seizure 22.35 9.62 13 88204 474 46597371
Asthma 22.30 9.62 93 88124 91449 46506396
Polydipsia 21.96 9.62 29 88188 3250 46594595
Delusional disorder, persecutory type 21.90 9.62 9 88208 150 46597695
Off label use 21.50 9.62 550 87667 379291 46218554
Carcinoid tumour of the stomach 21.47 9.62 9 88208 158 46597687
Aquagenic pruritus 21.46 9.62 6 88211 27 46597818
Cardiac arrest 21.37 9.62 263 87954 90136 46507709
Condition aggravated 21.36 9.62 330 87887 244722 46353123
Blood magnesium decreased 21.32 9.62 57 88160 10935 46586910
Oxygen saturation abnormal 21.31 9.62 26 88191 2692 46595153
Knee arthroplasty 21.30 9.62 9 88208 23656 46574189
Intentional overdose 21.27 9.62 58 88159 64886 46532959
Ascites 21.25 9.62 130 88087 36454 46561391
Hypergastrinaemia 21.20 9.62 8 88209 105 46597740
Enterochromaffin cell hyperplasia 21.11 9.62 7 88210 61 46597784
Blood pressure fluctuation 21.07 9.62 16 88201 30432 46567413
Adverse drug reaction 21.03 9.62 32 88185 44330 46553515
C-reactive protein abnormal 20.96 9.62 7 88210 21263 46576582
Product quality issue 20.75 9.62 22 88195 35626 46562219
Urticaria 20.70 9.62 134 88083 117758 46480087
Mobility decreased 20.70 9.62 53 88164 60541 46537304
Abdominal pain upper 20.13 9.62 386 87831 144919 46452926
Injection site haemorrhage 20.09 9.62 7 88210 20702 46577143
Malignant polyp 20.09 9.62 9 88208 187 46597658
Dysphagia 20.07 9.62 229 87988 77083 46520762
Neuropathy peripheral 20.02 9.62 261 87956 90632 46507213
Duodenal perforation 19.98 9.62 15 88202 844 46597001
Clonus 19.85 9.62 31 88186 4049 46593796
Foetal death 19.72 9.62 48 88169 8695 46589150
Thymus disorder 19.66 9.62 9 88208 197 46597648
Hip arthroplasty 19.61 9.62 5 88212 18107 46579738
Osteoporosis 19.53 9.62 29 88188 40579 46557266
Contusion 19.43 9.62 92 88125 87395 46510450
Pain in extremity 19.41 9.62 358 87859 258322 46339523
Ejection fraction decreased 19.27 9.62 76 88141 17861 46579984
Aortic rupture 19.27 9.62 7 88210 82 46597763
Inappropriate schedule of product administration 19.17 9.62 61 88156 64952 46532893
Terminal ileitis 19.16 9.62 8 88209 139 46597706
Headache 18.96 9.62 726 87491 477626 46120219
Anxiety disorder 18.96 9.62 28 88189 3483 46594362
Radiation pneumonitis 18.84 9.62 17 88200 1240 46596605
Catheter site bruise 18.81 9.62 10 88207 305 46597540
Hypocalcaemia 18.72 9.62 100 88117 26685 46571160
Myalgia 18.64 9.62 146 88071 122942 46474903
Red blood cell sedimentation rate increased 18.61 9.62 10 88207 22879 46574966
Aplasia 18.57 9.62 28 88189 3548 46594297
Onychalgia 18.56 9.62 13 88204 656 46597189
Herpes zoster 18.43 9.62 66 88151 67806 46530039
Acute interstitial pneumonitis 18.20 9.62 13 88204 677 46597168
Blood calcium decreased 18.15 9.62 68 88149 15605 46582240
Alveolitis 18.04 9.62 23 88194 2490 46595355
Heart rate decreased 18.00 9.62 20 88197 31703 46566142
Neuroleptic malignant syndrome 17.98 9.62 54 88163 11068 46586777
Bronchitis 17.83 9.62 122 88095 105857 46491988
Gait disturbance 17.75 9.62 182 88035 145081 46452764
Vitamin B12 decreased 17.75 9.62 24 88193 2751 46595094
Multiple organ dysfunction syndrome 17.64 9.62 162 88055 51548 46546297
Obstruction gastric 17.55 9.62 14 88203 862 46596983
Plantar erythema 17.53 9.62 9 88208 255 46597590
Torticollis 17.38 9.62 19 88198 1748 46596097
Oesophagitis 17.31 9.62 61 88156 13590 46584255
Parkinsonism 17.26 9.62 43 88174 7905 46589940
Intentional product misuse 17.05 9.62 40 88177 47088 46550757
Colitis 17.05 9.62 125 88092 37222 46560623
Pancytopenia 16.99 9.62 240 87977 84818 46513027
Hospitalisation 16.97 9.62 62 88155 63323 46534522
Pancreatitis 16.60 9.62 140 88077 43487 46554358
Hypoglycaemic seizure 16.59 9.62 11 88206 507 46597338
Staring 16.58 9.62 17 88200 1453 46596392
Haematemesis 16.50 9.62 102 88115 28704 46569141
Hypochloraemia 16.47 9.62 19 88198 1854 46595991
Hepatic enzyme increased 16.45 9.62 89 88128 81698 46516147
Peritonitis 16.34 9.62 80 88137 20634 46577211
Hypophagia 16.31 9.62 103 88114 29203 46568642
Biliary dyskinesia 16.26 9.62 23 88194 2750 46595095
Acute abdomen 15.99 9.62 17 88200 1515 46596330
Cholestasis 15.90 9.62 96 88121 26797 46571048
Haemangioma of skin 15.88 9.62 9 88208 312 46597533
Gallbladder injury 15.69 9.62 16 88201 1358 46596487
Diabetic gastroparesis 15.67 9.62 8 88209 224 46597621
Peripheral circulatory failure 15.40 9.62 9 88208 331 46597514
Respiratory failure 15.28 9.62 258 87959 94558 46503287
Bezoar 15.26 9.62 16 88201 1403 46596442
Neuroendocrine tumour 15.21 9.62 11 88206 584 46597261
Intestinal perforation 15.08 9.62 50 88167 10801 46587044
Febrile bone marrow aplasia 14.77 9.62 37 88180 6825 46591020
Thirst 14.74 9.62 50 88167 10926 46586919
Granulocytopenia neonatal 14.69 9.62 4 88213 16 46597829
Ileus paralytic 14.66 9.62 28 88189 4295 46593550
Injection site warmth 14.54 9.62 4 88213 13768 46584077
Porphyria acute 14.43 9.62 9 88208 373 46597472
Blood pressure systolic increased 14.39 9.62 20 88197 28767 46569078
Aspiration 14.22 9.62 45 88172 9486 46588359
Muscle contracture 14.15 9.62 15 88202 1332 46596513
Cholelithiasis 14.12 9.62 123 88094 38558 46559287
Vagus nerve disorder 14.08 9.62 6 88211 110 46597735
Adverse event 14.05 9.62 27 88190 34157 46563688
Pericarditis 13.67 9.62 15 88202 23912 46573933
Leukoencephalopathy 13.66 9.62 26 88191 3978 46593867
Feeling abnormal 13.56 9.62 161 88056 124899 46472946
Infusion related reaction 13.54 9.62 124 88093 101084 46496761
Vascular encephalopathy 13.53 9.62 9 88208 417 46597428
Drug resistance 13.53 9.62 8 88209 17360 46580485
Intestinal obstruction 13.50 9.62 90 88127 25985 46571860
Pulmonary air leakage 13.50 9.62 4 88213 23 46597822
Pneumonitis 13.48 9.62 96 88121 28324 46569521
Wound 13.44 9.62 39 88178 42763 46555082
Hyperpyrexia 13.43 9.62 21 88196 2745 46595100
Porphyria 13.42 9.62 6 88211 124 46597721
Autonomic neuropathy 13.42 9.62 11 88206 704 46597141
Therapy non-responder 13.29 9.62 37 88180 41115 46556730
Hypotension 13.15 9.62 551 87666 232038 46365807
Congenital musculoskeletal anomaly 13.14 9.62 9 88208 438 46597407
Patent ductus arteriosus 13.08 9.62 25 88192 3837 46594008
Drug clearance decreased 13.07 9.62 13 88204 1071 46596774
Premature baby 12.92 9.62 68 88149 18044 46579801
Foetal malpresentation 12.89 9.62 5 88212 71 46597774
Red blood cell spherocytes present 12.89 9.62 3 88214 5 46597840
Gaze palsy 12.84 9.62 14 88203 1284 46596561
Loss of personal independence in daily activities 12.77 9.62 60 88157 57123 46540722
Anaphylactic reaction 12.75 9.62 155 88062 52957 46544888
Suicide attempt 12.73 9.62 57 88160 54979 46542866
Stridor 12.73 9.62 22 88195 3125 46594720
Oesophageal ulcer 12.64 9.62 25 88192 3936 46593909
Urosepsis 12.62 9.62 60 88157 15293 46582552
Ventricular fibrillation 12.59 9.62 49 88168 11447 46586398
Intercepted product administration error 12.47 9.62 5 88212 78 46597767
Sinus disorder 12.39 9.62 8 88209 16555 46581290
Economic problem 12.21 9.62 17 88200 2003 46595842
Head titubation 12.19 9.62 10 88207 641 46597204
Joint injury 12.17 9.62 11 88206 19198 46578647
Toxicity to various agents 12.11 9.62 306 87911 211460 46386385
Multiple sclerosis relapse 12.08 9.62 40 88177 42085 46555760
Granulomatous liver disease 12.04 9.62 11 88206 815 46597030
Reflux gastritis 12.03 9.62 11 88206 816 46597029
Balance disorder 12.01 9.62 72 88145 64449 46533396
Neoplasm progression 12.00 9.62 89 88128 26594 46571251
Vascular pain 11.96 9.62 10 88207 658 46597187
Generalised tonic-clonic seizure 11.94 9.62 90 88127 27032 46570813
Hypersensitivity 11.90 9.62 206 88011 150115 46447730
Abdominal tenderness 11.90 9.62 35 88182 7093 46590752
Tooth disorder 11.84 9.62 16 88201 23287 46574558
Gastrointestinal necrosis 11.79 9.62 20 88197 2798 46595047
Hypoalbuminaemia 11.78 9.62 44 88173 10083 46587762
Throat irritation 11.73 9.62 23 88194 28878 46568967
Nasal congestion 11.64 9.62 49 88168 48064 46549781
Cystitis noninfective 11.63 9.62 11 88206 852 46596993
Blood bilirubin increased 11.61 9.62 107 88110 34077 46563768
Hydronephrosis 11.54 9.62 39 88178 8506 46589339
Eye pain 11.54 9.62 22 88195 27918 46569927
Joint stiffness 11.50 9.62 21 88196 27087 46570758
Deep vein thrombosis 11.41 9.62 213 88004 79560 46518285
Eructation 11.40 9.62 35 88182 7260 46590585
Chronic fatigue syndrome 11.38 9.62 12 88205 1059 46596786
Naevus haemorrhage 11.33 9.62 5 88212 100 46597745
Methaemoglobinaemia 11.33 9.62 17 88200 2145 46595700
Lethargy 11.29 9.62 147 88070 51024 46546821
Urinary tract infection enterococcal 11.25 9.62 18 88199 2400 46595445
Antiphospholipid syndrome 11.25 9.62 15 88202 1697 46596148
Fluid retention 11.14 9.62 54 88163 50992 46546853
Catatonia 11.12 9.62 23 88194 3739 46594106
Hepatic failure 11.05 9.62 104 88113 33312 46564533
Device dislocation 11.05 9.62 15 88202 21787 46576058
Myoclonus 11.01 9.62 55 88162 14297 46583548
Electrocardiogram T wave inversion 10.99 9.62 22 88195 3494 46594351
Therapy cessation 10.97 9.62 21 88196 26608 46571237
Leukostasis syndrome 10.92 9.62 4 88213 48 46597797
Lung infiltration 10.91 9.62 54 88163 13989 46583856
Device issue 10.90 9.62 13 88204 19967 46577878
Gastrointestinal stoma complication 10.75 9.62 14 88203 1547 46596298
Prolactin-producing pituitary tumour 10.73 9.62 5 88212 114 46597731
Mouth ulceration 10.69 9.62 87 88130 26745 46571100
Sinus arrhythmia 10.65 9.62 13 88204 1347 46596498
Incorrect dose administered 10.64 9.62 47 88170 45503 46552342
Ocular hyperaemia 10.56 9.62 13 88204 19697 46578148
Leukocytosis 10.50 9.62 78 88139 23320 46574525
Proctalgia 10.47 9.62 26 88191 4770 46593075
Brain oedema 10.43 9.62 49 88168 12429 46585416
Opisthotonus 10.42 9.62 7 88210 330 46597515
Lip erosion 10.42 9.62 10 88207 789 46597056
Foot fracture 10.41 9.62 13 88204 19569 46578276
Dyspnoea 10.39 9.62 1119 87098 514429 46083416
Nephrocalcinosis 10.39 9.62 11 88206 976 46596869
Tracheal injury 10.37 9.62 4 88213 56 46597789
Mucosal erosion 10.36 9.62 13 88204 1385 46596460
Peritoneal perforation 10.31 9.62 5 88212 125 46597720
Alopecia 10.30 9.62 231 87986 162183 46435662
Non-cardiac chest pain 10.29 9.62 30 88187 6048 46591797
Amylase increased 10.28 9.62 28 88189 5431 46592414
Immunodeficiency 10.26 9.62 6 88211 13100 46584745
Carpal tunnel syndrome 10.14 9.62 9 88208 15850 46581995
Visual impairment 10.14 9.62 79 88138 66610 46531235
Blood alkaline phosphatase increased 10.13 9.62 117 88100 39492 46558353
Joint effusion 10.11 9.62 5 88212 11990 46585855
Metastases to central nervous system 10.07 9.62 45 88172 11176 46586669
Injection site urticaria 10.07 9.62 5 88212 11962 46585883
Tumour pain 10.03 9.62 12 88205 1217 46596628
Bone density decreased 9.98 9.62 3 88214 9749 46588096
Computerised tomogram thorax 9.94 9.62 4 88213 63 46597782
Urea urine increased 9.88 9.62 3 88214 19 46597826
Disease progression 9.87 9.62 234 87983 91066 46506779
Hyperemesis gravidarum 9.85 9.62 8 88209 505 46597340
Abdominal mass 9.78 9.62 17 88200 2425 46595420
Febrile infection 9.77 9.62 12 88205 1251 46596594
Infusion site vesicles 9.76 9.62 7 88210 367 46597478
Musculoskeletal disorder 9.73 9.62 9 88208 15536 46582309
PCO2 decreased 9.73 9.62 12 88205 1256 46596589
Sciatica 9.72 9.62 13 88204 19007 46578838
Ultrasound abdomen abnormal 9.71 9.62 4 88213 67 46597778
Bursitis 9.71 9.62 14 88203 19828 46578017
Sopor 9.69 9.62 14 88203 19814 46578031
Calcium deficiency 9.67 9.62 10 88207 863 46596982

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Febrile neutropenia 252.57 10.28 578 53299 106115 29792486
Vomiting 252.34 10.28 917 52960 218901 29679700
Nausea 198.37 10.28 1053 52824 295904 29602697
Drug ineffective 186.73 10.28 203 53674 340184 29558417
General physical health deterioration 98.53 10.28 398 53479 99546 29799055
Dehydration 92.36 10.28 453 53424 123086 29775515
Drug abuse 85.82 10.28 21 53856 82051 29816550
Decreased appetite 74.58 10.28 493 53384 149417 29749184
Impaired gastric emptying 65.95 10.28 51 53826 3155 29895446
Serotonin syndrome 63.70 10.28 115 53762 17776 29880825
Constipation 62.73 10.28 382 53495 112524 29786077
Pyrexia 62.32 10.28 805 53072 293684 29604917
Product dose omission issue 55.30 10.28 50 53827 91581 29807020
Malignant neoplasm progression 51.75 10.28 262 53615 72025 29826576
Completed suicide 51.37 10.28 62 53815 99430 29799171
Neutropenia 51.28 10.28 401 53476 128139 29770462
Neutropenic sepsis 50.77 10.28 81 53796 11328 29887273
Dystonia 48.80 10.28 73 53804 9654 29888947
Drug intolerance 39.47 10.28 16 53861 45275 29853326
Psoriasis 38.73 10.28 14 53863 42492 29856109
Thrombocytopenia 38.43 10.28 396 53481 136648 29761953
Death 37.51 10.28 437 53440 356846 29541755
Sepsis 36.41 10.28 413 53464 145982 29752619
Rheumatoid arthritis 35.17 10.28 15 53862 41182 29857419
Hyponatraemia 33.93 10.28 222 53655 66980 29831621
Toxicity to various agents 32.71 10.28 186 53691 176997 29721604
Abdominal pain 32.07 10.28 379 53498 135275 29763326
Hypokalaemia 31.17 10.28 175 53702 50017 29848584
Therapeutic product effect incomplete 31.07 10.28 11 53866 33823 29864778
Neuroleptic malignant syndrome 30.67 10.28 81 53796 16214 29882387
Therapeutic product effect decreased 29.30 10.28 8 53869 29068 29869533
Hypophagia 28.96 10.28 97 53780 22139 29876462
Mesothelioma 28.93 10.28 15 53862 457 29898144
Alveolar lung disease 28.48 10.28 14 53863 380 29898221
Pneumonitis 28.32 10.28 111 53766 27343 29871258
Pulmonary interstitial emphysema syndrome 28.11 10.28 14 53863 391 29898210
Treatment failure 27.48 10.28 14 53863 34665 29863936
Intentional overdose 27.02 10.28 21 53856 41460 29857141
Peripheral swelling 26.57 10.28 43 53834 61031 29837570
Arthralgia 25.88 10.28 141 53736 135650 29762951
Malnutrition 25.85 10.28 61 53816 11388 29887213
Long QT syndrome 25.62 10.28 26 53851 2307 29896294
Hepatic failure 25.47 10.28 125 53752 33918 29864683
Haematopoietic stem cell mobilisation 24.68 10.28 10 53867 169 29898432
Weight increased 24.67 10.28 62 53815 74851 29823750
Oesophagitis 24.66 10.28 59 53818 11112 29887489
Electrocardiogram QT prolonged 24.31 10.28 128 53749 35707 29862894
Gastrointestinal hypermotility 24.09 10.28 9 53868 121 29898480
Toxic encephalopathy 23.71 10.28 35 53842 4574 29894027
Pleural effusion 23.14 10.28 219 53658 73847 29824754
Hyperthermia malignant 23.05 10.28 22 53855 1812 29896789
Talipes 22.79 10.28 21 53856 1654 29896947
Leukopenia 22.78 10.28 176 53701 55983 29842618
Ileus 22.19 10.28 70 53807 15485 29883116
Diarrhoea 22.08 10.28 770 53107 333333 29565268
Extrapyramidal disorder 22.03 10.28 55 53822 10638 29887963
Premature baby 21.90 10.28 73 53804 16618 29881983
Congenital pneumonia 21.80 10.28 8 53869 102 29898499
Hepatocellular injury 21.60 10.28 97 53780 25374 29873227
Ascites 21.48 10.28 124 53753 35797 29862804
Joint swelling 21.42 10.28 32 53845 46914 29851687
Hiccups 21.01 10.28 50 53827 9384 29889217
Myocardial infarction 20.99 10.28 136 53741 125489 29773112
Intentional product misuse 20.79 10.28 19 53858 34648 29863953
Cardiac failure congestive 20.62 10.28 80 53797 84327 29814274
Conjunctival irritation 20.50 10.28 8 53869 122 29898479
Enteritis 20.28 10.28 40 53837 6605 29891996
Anaemia 19.87 10.28 502 53375 207490 29691111
Suicide attempt 19.85 10.28 22 53855 36675 29861926
Delirium 19.75 10.28 133 53744 40498 29858103
Off label use 19.60 10.28 323 53554 248967 29649634
Pneumonia 19.54 10.28 760 53117 333546 29565055
Foetal exposure during pregnancy 19.33 10.28 123 53754 36748 29861853
Genital erythema 19.03 10.28 8 53869 149 29898452
Colitis 18.82 10.28 107 53770 30713 29867888
Pseudomonal sepsis 18.73 10.28 25 53852 2975 29895626
Electrocardiogram QT shortened 18.60 10.28 8 53869 158 29898443
Intentional product use issue 18.48 10.28 23 53854 36417 29862184
Cytokine storm 18.28 10.28 12 53865 572 29898029
Mucosal inflammation 18.06 10.28 105 53772 30389 29868212
Renal vasculitis 17.80 10.28 7 53870 109 29898492
Aplastic anaemia 17.63 10.28 34 53843 5522 29893079
Septic shock 17.41 10.28 183 53694 63424 29835177
Blood pressure fluctuation 17.29 10.28 5 53872 17498 29881103
Failure to thrive 17.20 10.28 42 53835 8012 29890589
Fall 16.92 10.28 228 53649 181644 29716957
Pulmonary embolism 16.57 10.28 214 53663 77921 29820680
Lower respiratory tract infection 16.48 10.28 93 53784 26621 29871980
Feeling abnormal 16.42 10.28 50 53827 56706 29841895
Acute abdomen 16.36 10.28 18 53859 1753 29896848
Laryngeal cancer metastatic 16.31 10.28 6 53871 77 29898524
Chemotherapeutic drug level increased 16.21 10.28 8 53869 219 29898382
Drug resistance 16.14 10.28 8 53869 20125 29878476
Tardive dyskinesia 16.11 10.28 31 53846 5026 29893575
Rash maculo-papular 16.02 10.28 89 53788 25329 29873272
Bacterial tracheitis 15.97 10.28 3 53874 0 29898601
Urticaria 15.88 10.28 48 53829 54558 29844043
Blood alkaline phosphatase increased 15.86 10.28 104 53773 31383 29867218
Condition aggravated 15.42 10.28 166 53711 137700 29760901
Subileus 15.24 10.28 23 53854 3064 29895537
Product use issue 15.21 10.28 38 53839 45978 29852623
Spleen congestion 14.97 10.28 9 53868 367 29898234
Ileus paralytic 14.88 10.28 32 53845 5616 29892985
Tumour lysis syndrome 14.86 10.28 54 53823 12831 29885770
Erectile dysfunction 14.81 10.28 7 53870 18095 29880506
Performance status decreased 14.80 10.28 26 53851 3931 29894670
Hyperbilirubinaemia 14.72 10.28 65 53812 16877 29881724
Psoriatic arthropathy 14.68 10.28 5 53872 15756 29882845
Headache 14.37 10.28 236 53641 182070 29716531
Product use in unapproved indication 14.31 10.28 76 53801 73617 29824984
Diaphragmatic rupture 14.16 10.28 4 53873 20 29898581
Aphthous ulcer 13.95 10.28 26 53851 4115 29894486
Creatine urine increased 13.89 10.28 3 53874 3 29898598
Abdominal compartment syndrome 13.88 10.28 12 53865 869 29897732
Diabetic gastroparesis 13.62 10.28 6 53871 126 29898475
Rheumatoid nodule 13.61 10.28 16 53861 1674 29896927
Drug clearance decreased 13.55 10.28 14 53863 1269 29897332
Wrong technique in product usage process 13.48 10.28 22 53855 31133 29867468
Asthma 13.47 10.28 28 53849 36146 29862455
Maternal drugs affecting foetus 13.38 10.28 26 53851 4247 29894354
Diffuse alveolar damage 13.30 10.28 17 53860 1939 29896662
Hypoalbuminaemia 13.23 10.28 47 53830 11045 29887556
Gait disturbance 12.97 10.28 80 53797 74697 29823904
Product quality issue 12.87 10.28 9 53868 18765 29879836
Dyschezia 12.87 10.28 13 53864 1147 29897454
Chills 12.85 10.28 192 53685 72146 29826455
Impetigo 12.75 10.28 11 53866 794 29897807
Intestinal ischaemia 12.69 10.28 34 53843 6863 29891738
Blood aluminium increased 12.68 10.28 3 53874 6 29898595
Pericardial effusion 12.64 10.28 73 53804 21071 29877530
Type III immune complex mediated reaction 12.61 10.28 7 53870 245 29898356
Tumour pain 12.57 10.28 12 53865 988 29897613
Injection site pain 12.56 10.28 22 53855 30288 29868313
Blood creatine phosphokinase increased 12.42 10.28 39 53838 43809 29854792
Device related infection 12.38 10.28 62 53815 16953 29881648
Hepatitis fulminant 12.36 10.28 24 53853 3917 29894684
Renal dysplasia 12.34 10.28 6 53871 159 29898442
Small intestinal obstruction 12.32 10.28 53 53824 13606 29884995
Dysphagia 12.32 10.28 156 53721 56542 29842059
Neutropenic infection 12.27 10.28 12 53865 1018 29897583
Disturbance in attention 12.26 10.28 13 53864 22116 29876485
Toxic epidermal necrolysis 12.10 10.28 64 53813 17876 29880725
Laparotomy 12.00 10.28 7 53870 270 29898331
Hygroma colli 11.86 10.28 4 53873 39 29898562
Cytokine release syndrome 11.77 10.28 42 53835 9891 29888710
Lactic acidosis 11.76 10.28 24 53853 31189 29867412
Arthropathy 11.69 10.28 12 53865 20715 29877886
Porphyria acute 11.48 10.28 5 53872 102 29898499
Immune-mediated hepatitis 11.47 10.28 12 53865 1104 29897497
Pulmonary sepsis 11.40 10.28 16 53861 1997 29896604
Gastrointestinal malformation 11.27 10.28 4 53873 46 29898555
Meconium abnormal 11.16 10.28 3 53874 12 29898589
Underdose 11.05 10.28 4 53873 12137 29886464
Hypoaesthesia 11.05 10.28 55 53822 54175 29844426
Skeletal dysplasia 10.93 10.28 5 53872 115 29898486
Heart rate decreased 10.91 10.28 13 53864 20981 29877620
Bradycardia 10.90 10.28 71 53806 65455 29833146
Spinal cord injury thoracic 10.85 10.28 5 53872 117 29898484
Non-small cell lung cancer 10.84 10.28 22 53855 3708 29894893
Hospitalisation 10.82 10.28 42 53835 44277 29854324
Calcium ionised increased 10.79 10.28 3 53874 14 29898587
Nasopharyngitis 10.71 10.28 62 53815 58787 29839814
Pain in extremity 10.66 10.28 137 53740 110084 29788517
Congenital nasal septum deviation 10.62 10.28 3 53874 15 29898586
Lenticulostriatal vasculopathy 10.62 10.28 3 53874 15 29898586
Cachexia 10.60 10.28 31 53846 6580 29892021
Sports injury 10.33 10.28 5 53872 131 29898470

Pharmacologic Action:

SourceCodeDescription
ATC A03FA01 ALIMENTARY TRACT AND METABOLISM
DRUGS FOR FUNCTIONAL GASTROINTESTINAL DISORDERS
PROPULSIVES
Propulsives
FDA MoA N0000175799 Dopamine D2 Antagonists
FDA EPC N0000175800 Dopamine-2 Receptor Antagonist
MeSH PA D000932 Antiemetics
MeSH PA D002491 Central Nervous System Agents
MeSH PA D015259 Dopamine Agents
MeSH PA D018492 Dopamine Antagonists
MeSH PA D065127 Dopamine D2 Receptor Antagonists
MeSH PA D005765 Gastrointestinal Agents
MeSH PA D018377 Neurotransmitter Agents
MeSH PA D018373 Peripheral Nervous System Agents
CHEBI has role CHEBI:35703 xenobiotic
CHEBI has role CHEBI:48561 dopamine blocker
CHEBI has role CHEBI:50919 antiemetico
CHEBI has role CHEBI:55324 gastrointestinal agents
CHEBI has role CHEBI:78298 environmental contaminants

Drug Use (View source of the data)

DiseaseRelationSNOMED_IDDOID
Diabetic gastroparesis indication 34140002
Intubation of gastrointestinal tract indication 235419001
Gastroesophageal reflux disease indication 235595009 DOID:8534
Chemotherapy-induced nausea and vomiting indication 236084000
Prevention of Post-Operative Nausea and Vomiting indication
Gastrointestinal Radiography Adjunct indication
Suicidal thoughts contraindication 6471006
Neuroleptic malignant syndrome contraindication 15244003 DOID:14464
Cirrhosis of liver contraindication 19943007 DOID:5082
Parkinsonism contraindication 32798002
Depressive disorder contraindication 35489007
Hypertensive disorder contraindication 38341003 DOID:10763
Body fluid retention contraindication 43498006
Mechanical ileus contraindication 46420000
Chronic heart failure contraindication 48447003
Gastrointestinal perforation contraindication 51875005
Gastrointestinal hemorrhage contraindication 74474003
Tardive dyskinesia contraindication 102449007
Deficiency of cytochrome-b>5< reductase contraindication 124184009
Seizure disorder contraindication 128613002
Impaired renal function disorder contraindication 197663003
Anastomosis of intestine contraindication 235407009
Pheochromocytoma contraindication 302835009
Porphyria contraindication 418470004
Acquired torsion dystonia contraindication 433493000

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 13.17 acidic
pKa2 8.94 Basic
pKa3 1.08 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
D(2) dopamine receptor GPCR ANTAGONIST Ki 7.19 WOMBAT-PK CHEMBL
5-hydroxytryptamine receptor 3A Ion channel ANTAGONIST Ki 6.70 WOMBAT-PK CHEMBL
5-hydroxytryptamine receptor 4 GPCR AGONIST EC50 6 WOMBAT-PK CHEMBL
5-hydroxytryptamine receptor 2B GPCR Ki 6.40 DRUG MATRIX
5-hydroxytryptamine receptor 2C GPCR Ki 5.90 DRUG MATRIX
Cytochrome P450 2D6 Enzyme IC50 6.10 DRUG MATRIX
Solute carrier family 22 member 1 Transporter IC50 4.02 CHEMBL
Aldehyde oxidase Enzyme IC50 4.51 WOMBAT-PK
Muscarinic acetylcholine receptor M1 GPCR WOMBAT-PK
D(3) dopamine receptor GPCR Ki 7.66 WOMBAT-PK
Serotonin 3 (5-HT3) receptor Ion channel Kd 7.30 CHEMBL
Alpha-2A adrenergic receptor GPCR Ki 5.99 DRUG MATRIX
5-hydroxytryptamine receptor 2A GPCR Ki 5.98 DRUG MATRIX
Serotonin 2 (5-HT2) receptor GPCR IC50 4.88 CHEMBL
Serotonin 3 receptor (5HT3) Ion channel Ki 6.70 CHEMBL
Adrenergic receptor alpha-2 GPCR IC50 5.11 CHEMBL
Serotonin 1 (5-HT1) receptor GPCR IC50 5.11 CHEMBL
D(2) dopamine receptor GPCR Ki 6.98 CHEMBL
Serotonin 3 (5-HT3) receptor Ion channel Ki 6.68 CHEMBL
Adrenergic receptor alpha-1 GPCR IC50 4.48 CHEMBL
D(2) dopamine receptor GPCR Ki 7.10 CHEMBL
D(3) dopamine receptor GPCR IC50 7.21 CHEMBL
5-hydroxytryptamine receptor 4 GPCR Ki 6.05 CHEMBL
5-hydroxytryptamine receptor 4 GPCR Ki 6.26 CHEMBL
D(2) dopamine receptor GPCR ANTAGONIST Ki 7.54 IUPHAR
5-hydroxytryptamine receptor 4 Unclassified AGONIST Ki 6 IUPHAR

External reference:

IDSource
4019835 VUID
N0000147923 NUI
D00726 KEGG_DRUG
54143-57-6 SECONDARY_CAS_RN
4017905 VANDF
4019835 VANDF
C0025853 UMLSCUI
CHEBI:107736 CHEBI
CHEMBL1200940 ChEMBL_ID
CHEMBL1256771 ChEMBL_ID
CHEMBL86 ChEMBL_ID
441347 PUBCHEM_CID
D008787 MESH_DESCRIPTOR_UI
DB01233 DRUGBANK_ID
241 IUPHAR_LIGAND_ID
1740 INN_ID
L4YEB44I46 UNII
267036 RXNORM
1062 MMSL
5099 MMSL
d00298 MMSL
001877 NDDF
004778 NDDF
31147000 SNOMEDCT_US
372776000 SNOMEDCT_US
56549003 SNOMEDCT_US

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
Metoclopramide HUMAN PRESCRIPTION DRUG LABEL 1 0093-2203 TABLET 10 mg ORAL ANDA 27 sections
Metoclopramide HUMAN PRESCRIPTION DRUG LABEL 1 0093-2204 TABLET 5 mg ORAL ANDA 27 sections
Metoclopramide Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 0115-1651 TABLET 10 mg ORAL ANDA 22 sections
Metoclopramide Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 0115-1652 TABLET 5 mg ORAL ANDA 22 sections
Metoclopramide HUMAN PRESCRIPTION DRUG LABEL 1 0121-0576 SOLUTION 5 mg ORAL ANDA 28 sections
Metoclopramide HUMAN PRESCRIPTION DRUG LABEL 1 0121-1576 SOLUTION 5 mg ORAL ANDA 28 sections
Metoclopramide HUMAN PRESCRIPTION DRUG LABEL 1 0409-3414 INJECTION, SOLUTION 5 mg INTRAMUSCULAR ANDA 15 sections
Metoclopramide HUMAN PRESCRIPTION DRUG LABEL 1 0440-1771 TABLET 10 mg ORAL ANDA 22 sections
Metoclopramide HUMAN PRESCRIPTION DRUG LABEL 1 0615-7698 TABLET 5 mg ORAL ANDA 27 sections
Metoclopramide HUMAN PRESCRIPTION DRUG LABEL 1 0615-8285 TABLET 10 mg ORAL ANDA 27 sections
Metoclopramide HUMAN PRESCRIPTION DRUG LABEL 1 0703-4502 INJECTION, SOLUTION 5 mg INTRAMUSCULAR ANDA 23 sections
Metoclopramide HUMAN PRESCRIPTION DRUG LABEL 1 12634-112 TABLET 10 mg ORAL ANDA 22 sections
METOCLOPRAMIDE HUMAN PRESCRIPTION DRUG LABEL 1 16590-150 TABLET 5 mg ORAL ANDA 25 sections
METOCLOPRAMIDE HUMAN PRESCRIPTION DRUG LABEL 1 16590-151 TABLET 10 mg ORAL ANDA 25 sections
REGLAN HUMAN PRESCRIPTION DRUG LABEL 1 16590-906 TABLET 10 mg ORAL NDA 24 sections
Metoclopramide HUMAN PRESCRIPTION DRUG LABEL 1 17856-0576 SOLUTION 5 mg ORAL ANDA 24 sections
Metoclopramide HUMAN PRESCRIPTION DRUG LABEL 1 21695-346 TABLET 10 mg ORAL ANDA 19 sections
Metoclopramide HUMAN PRESCRIPTION DRUG LABEL 1 21695-485 TABLET 5 mg ORAL ANDA 19 sections
Metoclopramide HUMAN PRESCRIPTION DRUG LABEL 1 23155-240 INJECTION 5 mg INTRAMUSCULAR ANDA 21 sections
Metoclopramide HUMAN PRESCRIPTION DRUG LABEL 1 33261-166 TABLET 10 mg ORAL ANDA 22 sections
METOCLOPRAMIDE hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 40032-580 TABLET, ORALLY DISINTEGRATING 10 mg ORAL ANDA 25 sections
METOCLOPRAMIDE hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 40032-581 TABLET, ORALLY DISINTEGRATING 5 mg ORAL ANDA 25 sections
Metoclopramide Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 42254-196 TABLET 5 mg ORAL ANDA 22 sections
Metoclopramide Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 42254-266 TABLET 10 mg ORAL ANDA 22 sections
Metoclopramide HUMAN PRESCRIPTION DRUG LABEL 1 42291-595 TABLET 5 mg ORAL ANDA 27 sections
Metoclopramide HUMAN PRESCRIPTION DRUG LABEL 1 42291-596 TABLET 10 mg ORAL ANDA 27 sections
Metoclopramide HUMAN PRESCRIPTION DRUG LABEL 1 43353-274 TABLET 10 mg ORAL ANDA 22 sections
Metoclopramide Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 43353-808 TABLET 10 mg ORAL ANDA 22 sections
METOCLOPRAMIDE hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 43386-580 TABLET, ORALLY DISINTEGRATING 10 mg ORAL ANDA 24 sections
METOCLOPRAMIDE hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 43386-581 TABLET, ORALLY DISINTEGRATING 5 mg ORAL ANDA 24 sections