Stem definition | Drug id | CAS RN |
---|---|---|
sulpiride derivatives | 1782 | 364-62-5 |
Dose | Unit | Route |
---|---|---|
30 | mg | O |
30 | mg | P |
30 | mg | R |
Property | Value | Reference |
---|---|---|
MRTD (Maximum Recommended Therapeutic Daily Dose) | 33.36 ยตM/kg/day | Contrera JF, Matthews EJ, Kruhlak NL, Benz RD |
BDDCS (Biopharmaceutical Drug Disposition Classification System) | 1 | Hosey CM, Chan R, Benet LZ |
S (Water solubility) | 0.20 mg/mL | Hosey CM, Chan R, Benet LZ |
EoM (Fraction excreted unchanged in urine) | 20 % | Hosey CM, Chan R, Benet LZ |
BA (Bioavailability) | 76 % | Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H |
Vd (Volume of distribution) | 3.20 L/kg | Lombardo F, Berellini G, Obach RS |
CL (Clearance) | 5.70 mL/min/kg | Lombardo F, Berellini G, Obach RS |
fu (Fraction unbound in plasma) | 0.60 % | Lombardo F, Berellini G, Obach RS |
t_half (Half-life) | 7.20 hours | Lombardo F, Berellini G, Obach RS |
Date | Agency | Company | Orphan |
---|---|---|---|
Feb. 7, 1979 | FDA | BAXTER HLTHCARE CORP |
MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
---|---|---|---|---|---|---|
Drug ineffective | 514.41 | 9.93 | 507 | 98132 | 818826 | 49687659 |
Febrile neutropenia | 367.13 | 9.93 | 672 | 97967 | 96995 | 50409490 |
Vomiting | 365.08 | 9.93 | 1816 | 96823 | 458942 | 50047543 |
Joint swelling | 255.89 | 9.93 | 80 | 98559 | 245206 | 50261279 |
Rheumatoid arthritis | 252.70 | 9.93 | 45 | 98594 | 202505 | 50303980 |
Drug intolerance | 248.05 | 9.93 | 61 | 98578 | 219043 | 50287442 |
Contraindicated product administered | 217.21 | 9.93 | 20 | 98619 | 148938 | 50357547 |
Arthropathy | 188.59 | 9.93 | 39 | 98600 | 157867 | 50348618 |
Therapeutic product effect decreased | 186.25 | 9.93 | 23 | 98616 | 136027 | 50370458 |
Synovitis | 185.02 | 9.93 | 15 | 98624 | 123850 | 50382635 |
Hand deformity | 175.94 | 9.93 | 4 | 98635 | 100195 | 50406290 |
Hypokalaemia | 171.73 | 9.93 | 466 | 98173 | 87526 | 50418959 |
Nausea | 169.64 | 9.93 | 2106 | 96533 | 703292 | 49803193 |
Neutropenic sepsis | 159.65 | 9.93 | 166 | 98473 | 13981 | 50492504 |
Swelling | 155.48 | 9.93 | 100 | 98539 | 200772 | 50305713 |
Systemic lupus erythematosus | 153.59 | 9.93 | 42 | 98597 | 140580 | 50365905 |
Arthralgia | 150.74 | 9.93 | 402 | 98237 | 438300 | 50068185 |
Glossodynia | 149.99 | 9.93 | 23 | 98616 | 115546 | 50390939 |
Abdominal discomfort | 131.24 | 9.93 | 155 | 98484 | 231486 | 50274999 |
Dehydration | 130.00 | 9.93 | 615 | 98024 | 151834 | 50354651 |
Dystonia | 129.33 | 9.93 | 137 | 98502 | 11789 | 50494696 |
Weight increased | 124.39 | 9.93 | 126 | 98513 | 201765 | 50304720 |
Pyrexia | 114.74 | 9.93 | 1188 | 97451 | 379015 | 50127470 |
Sinusitis | 113.80 | 9.93 | 99 | 98540 | 170459 | 50336026 |
Neutropenia | 113.35 | 9.93 | 579 | 98060 | 147386 | 50359099 |
Abdominal pain | 107.45 | 9.93 | 808 | 97831 | 235420 | 50271065 |
General physical health deterioration | 105.38 | 9.93 | 552 | 98087 | 141882 | 50364603 |
Mucosal inflammation | 104.02 | 9.93 | 237 | 98402 | 39905 | 50466580 |
Extrapyramidal disorder | 103.19 | 9.93 | 121 | 98518 | 11649 | 50494836 |
Pain | 99.50 | 9.93 | 691 | 97948 | 578212 | 49928273 |
Hyponatraemia | 99.44 | 9.93 | 411 | 98228 | 95728 | 50410757 |
Injection site pain | 99.32 | 9.93 | 46 | 98593 | 110978 | 50395507 |
Pericarditis | 99.08 | 9.93 | 17 | 98622 | 78672 | 50427813 |
Hypomagnesaemia | 98.01 | 9.93 | 168 | 98471 | 22988 | 50483497 |
Thrombocytopenia | 96.64 | 9.93 | 498 | 98141 | 127175 | 50379310 |
Wound | 95.94 | 9.93 | 43 | 98596 | 105751 | 50400734 |
Product use issue | 95.84 | 9.93 | 90 | 98549 | 149385 | 50357100 |
Product dose omission issue | 95.78 | 9.93 | 131 | 98508 | 183707 | 50322778 |
Decreased appetite | 94.59 | 9.93 | 693 | 97946 | 200230 | 50306255 |
Nasopharyngitis | 93.14 | 9.93 | 145 | 98494 | 192782 | 50313703 |
Impaired gastric emptying | 92.50 | 9.93 | 99 | 98540 | 8619 | 50497866 |
Tardive dyskinesia | 92.34 | 9.93 | 91 | 98548 | 7188 | 50499297 |
Torsade de pointes | 91.25 | 9.93 | 114 | 98525 | 11721 | 50494764 |
Constipation | 87.10 | 9.93 | 640 | 97999 | 185068 | 50321417 |
Peripheral swelling | 86.48 | 9.93 | 169 | 98470 | 205767 | 50300718 |
Completed suicide | 85.02 | 9.93 | 79 | 98560 | 131810 | 50374675 |
Treatment failure | 84.61 | 9.93 | 86 | 98553 | 137551 | 50368934 |
Toxic epidermal necrolysis | 83.25 | 9.93 | 148 | 98491 | 20844 | 50485641 |
Atelectasis | 81.90 | 9.93 | 136 | 98503 | 18134 | 50488351 |
Discomfort | 81.02 | 9.93 | 56 | 98583 | 108324 | 50398161 |
Serotonin syndrome | 76.73 | 9.93 | 157 | 98482 | 24556 | 50481929 |
Phaeochromocytoma crisis | 76.30 | 9.93 | 25 | 98614 | 202 | 50506283 |
Anaemia | 74.14 | 9.93 | 785 | 97854 | 251671 | 50254814 |
Diarrhoea | 73.33 | 9.93 | 1578 | 97061 | 586898 | 49919587 |
Pulmonary embolism | 72.33 | 9.93 | 390 | 98249 | 101314 | 50405171 |
Musculoskeletal stiffness | 70.53 | 9.93 | 88 | 98551 | 128393 | 50378092 |
Malignant neoplasm progression | 70.23 | 9.93 | 291 | 98348 | 67833 | 50438652 |
Duodenal ulcer perforation | 69.55 | 9.93 | 5 | 98634 | 45606 | 50460879 |
Therapeutic product effect incomplete | 68.78 | 9.93 | 47 | 98592 | 91468 | 50415017 |
Hepatic enzyme increased | 63.68 | 9.93 | 106 | 98533 | 137274 | 50369211 |
Cholecystitis chronic | 61.91 | 9.93 | 85 | 98554 | 9584 | 50496901 |
Psoriatic arthropathy | 61.82 | 9.93 | 9 | 98630 | 47023 | 50459462 |
Acute kidney injury | 61.80 | 9.93 | 698 | 97941 | 227360 | 50279125 |
Neutrophil count decreased | 60.97 | 9.93 | 213 | 98426 | 45813 | 50460672 |
Electrocardiogram QT prolonged | 59.37 | 9.93 | 229 | 98410 | 51657 | 50454828 |
Neovascularisation | 59.11 | 9.93 | 32 | 98607 | 981 | 50505504 |
Parkinsonism | 58.50 | 9.93 | 79 | 98560 | 8768 | 50497717 |
Helicobacter infection | 55.83 | 9.93 | 14 | 98625 | 49688 | 50456797 |
Hypersensitivity | 55.10 | 9.93 | 224 | 98415 | 214937 | 50291548 |
Computerised tomogram thorax abnormal | 54.88 | 9.93 | 34 | 98605 | 1349 | 50505136 |
Alopecia | 53.84 | 9.93 | 270 | 98369 | 244777 | 50261708 |
Psoriasis | 53.79 | 9.93 | 34 | 98605 | 68966 | 50437519 |
Gastritis | 52.99 | 9.93 | 163 | 98476 | 32820 | 50473665 |
Arthritis | 51.23 | 9.93 | 56 | 98583 | 86665 | 50419820 |
Infusion related reaction | 50.33 | 9.93 | 166 | 98473 | 169391 | 50337094 |
Sepsis | 49.65 | 9.93 | 435 | 98204 | 132490 | 50373995 |
Impaired healing | 49.62 | 9.93 | 38 | 98601 | 69748 | 50436737 |
Phaeochromocytoma | 48.94 | 9.93 | 22 | 98617 | 446 | 50506039 |
Hypoxia | 46.26 | 9.93 | 210 | 98429 | 50913 | 50455572 |
Ileus | 45.83 | 9.93 | 88 | 98551 | 13141 | 50493344 |
Restlessness | 45.77 | 9.93 | 130 | 98509 | 25043 | 50481442 |
Cytokine release syndrome | 45.20 | 9.93 | 69 | 98570 | 8565 | 50497920 |
Renal ischaemia | 44.37 | 9.93 | 22 | 98617 | 560 | 50505925 |
Injection site bruising | 44.01 | 9.93 | 9 | 98630 | 36759 | 50469726 |
Stevens-Johnson syndrome | 43.18 | 9.93 | 116 | 98523 | 21636 | 50484849 |
Knee arthroplasty | 42.45 | 9.93 | 9 | 98630 | 35837 | 50470648 |
Hip arthroplasty | 41.96 | 9.93 | 5 | 98634 | 30424 | 50476061 |
Neuropathy peripheral | 41.66 | 9.93 | 327 | 98312 | 96430 | 50410055 |
Device expulsion | 41.62 | 9.93 | 4 | 98635 | 28818 | 50477667 |
Duodenal stenosis | 41.56 | 9.93 | 20 | 98619 | 476 | 50506009 |
Cardiac arrest | 40.70 | 9.93 | 291 | 98348 | 83360 | 50423125 |
Irritable bowel syndrome | 40.57 | 9.93 | 25 | 98614 | 51416 | 50455069 |
Folliculitis | 40.44 | 9.93 | 13 | 98626 | 39212 | 50467273 |
Leukopenia | 40.16 | 9.93 | 247 | 98392 | 67281 | 50439204 |
Electrolyte imbalance | 39.71 | 9.93 | 97 | 98542 | 17072 | 50489413 |
Encephalopathy | 39.56 | 9.93 | 150 | 98489 | 33561 | 50472924 |
Injection site erythema | 39.38 | 9.93 | 53 | 98586 | 74883 | 50431602 |
Septic shock | 39.10 | 9.93 | 217 | 98422 | 56958 | 50449527 |
Tachycardia | 39.08 | 9.93 | 330 | 98309 | 99433 | 50407052 |
Colitis | 38.45 | 9.93 | 163 | 98476 | 38366 | 50468119 |
Pleural effusion | 38.27 | 9.93 | 281 | 98358 | 81173 | 50425312 |
Contusion | 38.19 | 9.93 | 103 | 98536 | 112080 | 50394405 |
PCO2 increased | 37.68 | 9.93 | 25 | 98614 | 1118 | 50505367 |
PO2 increased | 37.24 | 9.93 | 22 | 98617 | 800 | 50505685 |
Cholecystitis | 37.15 | 9.93 | 83 | 98556 | 13788 | 50492697 |
Diabetes insipidus | 36.58 | 9.93 | 33 | 98606 | 2331 | 50504154 |
Subileus | 35.94 | 9.93 | 35 | 98604 | 2724 | 50503761 |
Left ventricular dysfunction | 35.31 | 9.93 | 69 | 98570 | 10437 | 50496048 |
Blood pressure increased | 35.06 | 9.93 | 137 | 98502 | 132995 | 50373490 |
Wrong technique in product usage process | 34.87 | 9.93 | 34 | 98605 | 55476 | 50451009 |
Rash | 34.76 | 9.93 | 622 | 98017 | 436849 | 50069636 |
Injection site reaction | 34.61 | 9.93 | 28 | 98611 | 50004 | 50456481 |
Blood bicarbonate decreased | 34.44 | 9.93 | 34 | 98605 | 2691 | 50503794 |
Malnutrition | 34.30 | 9.93 | 78 | 98561 | 13111 | 50493374 |
Aplastic anaemia | 34.06 | 9.93 | 57 | 98582 | 7646 | 50498839 |
Cholestasis | 34.02 | 9.93 | 118 | 98521 | 25283 | 50481202 |
Dysphagia | 33.92 | 9.93 | 263 | 98376 | 77255 | 50429230 |
Dyskinesia | 33.54 | 9.93 | 125 | 98514 | 27736 | 50478749 |
Injection site swelling | 33.36 | 9.93 | 20 | 98619 | 41753 | 50464732 |
Abortion spontaneous | 33.36 | 9.93 | 20 | 98619 | 41752 | 50464733 |
Adverse drug reaction | 33.35 | 9.93 | 35 | 98604 | 55187 | 50451298 |
Rash maculo-papular | 33.31 | 9.93 | 121 | 98518 | 26520 | 50479965 |
Mouth ulceration | 33.13 | 9.93 | 125 | 98514 | 27899 | 50478586 |
Aplasia | 33.09 | 9.93 | 39 | 98600 | 3774 | 50502711 |
C-reactive protein abnormal | 32.89 | 9.93 | 7 | 98632 | 27802 | 50478683 |
Injection site pruritus | 32.77 | 9.93 | 19 | 98620 | 40392 | 50466093 |
Condition aggravated | 32.74 | 9.93 | 396 | 98243 | 296662 | 50209823 |
Akathisia | 32.60 | 9.93 | 58 | 98581 | 8171 | 50498314 |
Hepatocellular injury | 32.57 | 9.93 | 118 | 98521 | 25829 | 50480656 |
Oculogyric crisis | 32.53 | 9.93 | 25 | 98614 | 1412 | 50505073 |
Excessive eye blinking | 31.93 | 9.93 | 21 | 98618 | 925 | 50505560 |
Disease progression | 31.37 | 9.93 | 305 | 98334 | 95561 | 50410924 |
Small intestinal obstruction | 31.20 | 9.93 | 85 | 98554 | 15983 | 50490502 |
Mixed liver injury | 31.12 | 9.93 | 36 | 98603 | 3415 | 50503070 |
Osteoarthritis | 30.79 | 9.93 | 54 | 98585 | 68552 | 50437933 |
Therapeutic response decreased | 30.76 | 9.93 | 28 | 98611 | 47203 | 50459282 |
Peripheral circulatory failure | 30.71 | 9.93 | 17 | 98622 | 545 | 50505940 |
Haematemesis | 30.60 | 9.93 | 121 | 98518 | 27604 | 50478881 |
Hypotension | 30.27 | 9.93 | 635 | 98004 | 234834 | 50271651 |
Gastroenteritis | 30.18 | 9.93 | 107 | 98532 | 23174 | 50483311 |
Hyperprolactinaemia | 30.17 | 9.93 | 35 | 98604 | 3330 | 50503155 |
Peritonitis | 30.15 | 9.93 | 82 | 98557 | 15404 | 50491081 |
Red blood cell sedimentation rate increased | 29.89 | 9.93 | 10 | 98629 | 29406 | 50477079 |
Pancytopenia | 29.31 | 9.93 | 271 | 98368 | 83759 | 50422726 |
Ascites | 29.28 | 9.93 | 143 | 98496 | 35718 | 50470767 |
Ejection fraction decreased | 29.25 | 9.93 | 91 | 98548 | 18429 | 50488056 |
Accidental exposure to product | 28.97 | 9.93 | 5 | 98634 | 23052 | 50483433 |
Antinuclear antibody negative | 28.62 | 9.93 | 12 | 98627 | 204 | 50506281 |
Respiratory syncytial virus infection | 28.46 | 9.93 | 42 | 98597 | 5060 | 50501425 |
Influenza | 28.42 | 9.93 | 85 | 98554 | 89453 | 50417032 |
Mobility decreased | 27.51 | 9.93 | 73 | 98566 | 79875 | 50426610 |
Adverse event | 27.26 | 9.93 | 27 | 98612 | 43736 | 50462749 |
Pain in extremity | 27.01 | 9.93 | 372 | 98267 | 272493 | 50233992 |
Emotional distress | 26.87 | 9.93 | 119 | 98520 | 28544 | 50477941 |
Blood magnesium decreased | 26.83 | 9.93 | 64 | 98575 | 11096 | 50495389 |
Coombs positive haemolytic anaemia | 26.39 | 9.93 | 13 | 98626 | 326 | 50506159 |
Paradoxical drug reaction | 26.32 | 9.93 | 34 | 98605 | 3613 | 50502872 |
Blood pressure fluctuation | 26.11 | 9.93 | 19 | 98620 | 35804 | 50470681 |
Urticaria | 26.05 | 9.93 | 147 | 98492 | 129414 | 50377071 |
Infusion site streaking | 25.84 | 9.93 | 14 | 98625 | 430 | 50506055 |
Abdominal pain upper | 25.73 | 9.93 | 445 | 98194 | 158864 | 50347621 |
Skin candida | 25.58 | 9.93 | 21 | 98618 | 1305 | 50505180 |
Polydipsia | 25.54 | 9.93 | 31 | 98608 | 3093 | 50503392 |
Alveolitis | 25.52 | 9.93 | 28 | 98611 | 2506 | 50503979 |
Computerised tomogram thorax | 25.30 | 9.93 | 10 | 98629 | 145 | 50506340 |
Respiratory dyskinesia | 25.29 | 9.93 | 7 | 98632 | 29 | 50506456 |
Onychalgia | 25.27 | 9.93 | 17 | 98622 | 778 | 50505707 |
Blood cholesterol increased | 25.20 | 9.93 | 43 | 98596 | 55172 | 50451313 |
Gamma-glutamyltransferase increased | 24.82 | 9.93 | 119 | 98520 | 29504 | 50476981 |
Heart rate decreased | 24.53 | 9.93 | 21 | 98618 | 36476 | 50470009 |
Blood pH decreased | 24.51 | 9.93 | 27 | 98612 | 2428 | 50504057 |
Herpes simplex reactivation | 24.45 | 9.93 | 13 | 98626 | 384 | 50506101 |
Erysipelas | 24.18 | 9.93 | 45 | 98594 | 6563 | 50499922 |
Therapy non-responder | 23.96 | 9.93 | 39 | 98600 | 50983 | 50455502 |
Secondary adrenocortical insufficiency | 23.95 | 9.93 | 19 | 98620 | 1124 | 50505361 |
Hyponatraemic seizure | 23.88 | 9.93 | 13 | 98626 | 403 | 50506082 |
Immune effector cell-associated neurotoxicity syndrome | 23.85 | 9.93 | 19 | 98620 | 1131 | 50505354 |
Hypocalcaemia | 23.39 | 9.93 | 109 | 98530 | 26707 | 50479778 |
Gastritis haemorrhagic | 23.37 | 9.93 | 20 | 98619 | 1317 | 50505168 |
Cataract | 23.31 | 9.93 | 35 | 98604 | 47265 | 50459220 |
Oesophagitis | 23.25 | 9.93 | 68 | 98571 | 13315 | 50493170 |
Gelastic seizure | 22.76 | 9.93 | 5 | 98634 | 5 | 50506480 |
Neuroleptic malignant syndrome | 22.74 | 9.93 | 60 | 98579 | 11070 | 50495415 |
Ventricular fibrillation | 22.68 | 9.93 | 58 | 98581 | 10501 | 50495984 |
Fall | 22.38 | 9.93 | 490 | 98149 | 334442 | 50172043 |
Respiratory failure | 22.38 | 9.93 | 274 | 98365 | 90907 | 50415578 |
Pancreatitis | 22.34 | 9.93 | 151 | 98488 | 42463 | 50464022 |
Pneumonitis | 22.21 | 9.93 | 115 | 98524 | 29395 | 50477090 |
Multiple organ dysfunction syndrome | 22.14 | 9.93 | 171 | 98468 | 50166 | 50456319 |
Febrile bone marrow aplasia | 21.88 | 9.93 | 42 | 98597 | 6269 | 50500216 |
Dyspnoea | 21.81 | 9.93 | 1289 | 97350 | 546319 | 49960166 |
No adverse event | 21.75 | 9.93 | 20 | 98619 | 33558 | 50472927 |
Brain oedema | 21.63 | 9.93 | 63 | 98576 | 12307 | 50494178 |
Thymus disorder | 21.58 | 9.93 | 10 | 98629 | 218 | 50506267 |
Hypergastrinaemia | 21.46 | 9.93 | 8 | 98631 | 98 | 50506387 |
Carcinoid tumour of the stomach | 21.36 | 9.93 | 9 | 98630 | 155 | 50506330 |
Enterochromaffin cell hyperplasia | 21.32 | 9.93 | 7 | 98632 | 57 | 50506428 |
Aquagenic pruritus | 21.28 | 9.93 | 6 | 98633 | 27 | 50506458 |
Urinary retention | 21.07 | 9.93 | 104 | 98535 | 26086 | 50480399 |
Maternal exposure during pregnancy | 20.77 | 9.93 | 205 | 98434 | 159573 | 50346912 |
Drug interaction | 20.57 | 9.93 | 522 | 98117 | 199099 | 50307386 |
Deep vein thrombosis | 20.54 | 9.93 | 226 | 98413 | 73078 | 50433407 |
Loss of personal independence in daily activities | 20.47 | 9.93 | 69 | 98570 | 69981 | 50436504 |
Delusional disorder, persecutory type | 20.46 | 9.93 | 9 | 98630 | 173 | 50506312 |
Pituitary tumour benign | 20.27 | 9.93 | 21 | 98618 | 1760 | 50504725 |
Malignant polyp | 20.27 | 9.93 | 9 | 98630 | 177 | 50506308 |
Cholelithiasis | 20.17 | 9.93 | 135 | 98504 | 37838 | 50468647 |
Nail infection | 20.14 | 9.93 | 22 | 98617 | 1959 | 50504526 |
Urosepsis | 19.98 | 9.93 | 71 | 98568 | 15394 | 50491091 |
Intestinal perforation | 19.91 | 9.93 | 55 | 98584 | 10424 | 50496061 |
Foetal death | 19.76 | 9.93 | 47 | 98592 | 8133 | 50498352 |
Obstruction gastric | 19.72 | 9.93 | 15 | 98624 | 834 | 50505651 |
Duodenal perforation | 19.59 | 9.93 | 14 | 98625 | 707 | 50505778 |
Fatigue | 19.57 | 9.93 | 1155 | 97484 | 706446 | 49800039 |
Ill-defined disorder | 19.49 | 9.93 | 49 | 98590 | 54605 | 50451880 |
Radiation pneumonitis | 19.42 | 9.93 | 18 | 98621 | 1317 | 50505168 |
Oxygen saturation abnormal | 19.21 | 9.93 | 25 | 98614 | 2677 | 50503808 |
Herpes zoster | 19.17 | 9.93 | 72 | 98567 | 70714 | 50435771 |
Intentional product use issue | 19.08 | 9.93 | 81 | 98558 | 76837 | 50429648 |
Acute interstitial pneumonitis | 19.04 | 9.93 | 13 | 98626 | 610 | 50505875 |
Aortic rupture | 18.98 | 9.93 | 7 | 98632 | 83 | 50506402 |
Torticollis | 18.92 | 9.93 | 20 | 98619 | 1716 | 50504769 |
Injection site haemorrhage | 18.83 | 9.93 | 9 | 98630 | 21337 | 50485148 |
Hypophagia | 18.79 | 9.93 | 105 | 98534 | 27623 | 50478862 |
Anxiety disorder | 18.73 | 9.93 | 29 | 98610 | 3644 | 50502841 |
Plantar erythema | 18.71 | 9.93 | 9 | 98630 | 214 | 50506271 |
Clonus | 18.60 | 9.93 | 31 | 98608 | 4144 | 50502341 |
Agitation | 18.52 | 9.93 | 172 | 98467 | 53212 | 50453273 |
Electrocardiogram T wave inversion | 18.41 | 9.93 | 27 | 98612 | 3234 | 50503251 |
Vitamin B12 decreased | 18.40 | 9.93 | 25 | 98614 | 2790 | 50503695 |
Catheter site bruise | 18.20 | 9.93 | 10 | 98629 | 316 | 50506169 |
Acute abdomen | 18.09 | 9.93 | 18 | 98621 | 1438 | 50505047 |
Lethargy | 18.03 | 9.93 | 161 | 98478 | 49271 | 50457214 |
Hypochloraemia | 18.00 | 9.93 | 19 | 98620 | 1628 | 50504857 |
Seizure | 17.86 | 9.93 | 326 | 98313 | 117548 | 50388937 |
Blood pressure systolic increased | 17.69 | 9.93 | 26 | 98613 | 35423 | 50471062 |
Pneumonia | 17.65 | 9.93 | 904 | 97735 | 377497 | 50128988 |
Asthma | 17.61 | 9.93 | 102 | 98537 | 89235 | 50417250 |
Thirst | 17.44 | 9.93 | 53 | 98586 | 10597 | 50495888 |
Long QT syndrome | 17.38 | 9.93 | 25 | 98614 | 2942 | 50503543 |
Pancreatitis acute | 17.37 | 9.93 | 92 | 98547 | 23720 | 50482765 |
Hypoglycaemic seizure | 17.37 | 9.93 | 11 | 98628 | 454 | 50506031 |
Blood alkaline phosphatase increased | 17.35 | 9.93 | 129 | 98510 | 37397 | 50469088 |
Inappropriate schedule of product administration | 16.99 | 9.93 | 77 | 98562 | 71754 | 50434731 |
Joint injury | 16.62 | 9.93 | 11 | 98628 | 21778 | 50484707 |
Bronchitis | 16.47 | 9.93 | 127 | 98512 | 104032 | 50402453 |
Nervous system disorder | 16.47 | 9.93 | 69 | 98570 | 16154 | 50490331 |
Disturbance in social behaviour | 16.40 | 9.93 | 24 | 98615 | 2870 | 50503615 |
Premature baby | 16.34 | 9.93 | 75 | 98564 | 18262 | 50488223 |
Dyspepsia | 16.21 | 9.93 | 218 | 98421 | 73879 | 50432606 |
Staring | 16.10 | 9.93 | 17 | 98622 | 1457 | 50505028 |
Gallbladder injury | 16.08 | 9.93 | 16 | 98623 | 1278 | 50505207 |
Intentional overdose | 16.01 | 9.93 | 65 | 98574 | 62439 | 50444046 |
Confusional state | 15.98 | 9.93 | 475 | 98164 | 185453 | 50321032 |
Hospitalisation | 15.97 | 9.93 | 73 | 98566 | 67864 | 50438621 |
Headache | 15.96 | 9.93 | 816 | 97823 | 505719 | 50000766 |
Sinus disorder | 15.95 | 9.93 | 8 | 98631 | 18450 | 50488035 |
Haemangioma of skin | 15.91 | 9.93 | 9 | 98630 | 301 | 50506184 |
Gastrointestinal stoma complication | 15.76 | 9.93 | 17 | 98622 | 1493 | 50504992 |
Gait disturbance | 15.73 | 9.93 | 202 | 98437 | 149803 | 50356682 |
Biliary dyskinesia | 15.70 | 9.93 | 22 | 98617 | 2528 | 50503957 |
Neuroendocrine tumour | 15.54 | 9.93 | 11 | 98628 | 547 | 50505938 |
Multiple drug therapy | 15.48 | 9.93 | 19 | 98620 | 1918 | 50504567 |
Cancer pain | 15.45 | 9.93 | 22 | 98617 | 2565 | 50503920 |
Drug resistance | 15.29 | 9.93 | 9 | 98630 | 18980 | 50487505 |
Pruritus | 15.09 | 9.93 | 429 | 98210 | 283139 | 50223346 |
Hepatic failure | 14.94 | 9.93 | 111 | 98528 | 32172 | 50474313 |
Blood bilirubin increased | 14.74 | 9.93 | 110 | 98529 | 31928 | 50474557 |
Infection | 14.61 | 9.93 | 243 | 98396 | 172711 | 50333774 |
Product storage error | 14.61 | 9.93 | 3 | 98636 | 12221 | 50494264 |
Granulocytopenia neonatal | 14.56 | 9.93 | 4 | 98635 | 16 | 50506469 |
Nasal congestion | 14.50 | 9.93 | 51 | 98588 | 51069 | 50455416 |
Grip strength decreased | 14.44 | 9.93 | 3 | 98636 | 12118 | 50494367 |
Joint stiffness | 14.39 | 9.93 | 23 | 98616 | 30285 | 50476200 |
Vagus nerve disorder | 14.26 | 9.93 | 6 | 98633 | 103 | 50506382 |
Multiple sclerosis relapse | 14.20 | 9.93 | 40 | 98599 | 42924 | 50463561 |
Haemorrhoids | 14.16 | 9.93 | 74 | 98565 | 18979 | 50487506 |
Aspiration | 14.15 | 9.93 | 45 | 98594 | 9219 | 50497266 |
Intestinal obstruction | 14.13 | 9.93 | 94 | 98545 | 26289 | 50480196 |
Enterocolitis | 14.03 | 9.93 | 36 | 98603 | 6531 | 50499954 |
Vascular encephalopathy | 14.00 | 9.93 | 9 | 98630 | 381 | 50506104 |
Anuria | 13.99 | 9.93 | 51 | 98588 | 11193 | 50495292 |
Feeling abnormal | 13.90 | 9.93 | 167 | 98472 | 125325 | 50381160 |
Drug clearance decreased | 13.90 | 9.93 | 14 | 98625 | 1135 | 50505350 |
Cystitis noninfective | 13.87 | 9.93 | 12 | 98627 | 802 | 50505683 |
Bezoar | 13.76 | 9.93 | 15 | 98624 | 1333 | 50505152 |
Bone erosion | 13.70 | 9.93 | 3 | 98636 | 11684 | 50494801 |
Leukoencephalopathy | 13.66 | 9.93 | 26 | 98613 | 3857 | 50502628 |
Meconium ileus | 13.65 | 9.93 | 3 | 98636 | 3 | 50506482 |
Renal failure | 13.49 | 9.93 | 287 | 98352 | 106346 | 50400139 |
Immunodeficiency | 13.47 | 9.93 | 6 | 98633 | 14822 | 50491663 |
Presyncope | 13.44 | 9.93 | 87 | 98552 | 24111 | 50482374 |
Throat irritation | 13.38 | 9.93 | 24 | 98615 | 30215 | 50476270 |
Gastrointestinal submucosal tumour | 13.38 | 9.93 | 4 | 98635 | 23 | 50506462 |
Pulmonary air leakage | 13.38 | 9.93 | 4 | 98635 | 23 | 50506462 |
Hypoalbuminaemia | 13.37 | 9.93 | 46 | 98593 | 9814 | 50496671 |
Non-small cell lung cancer | 13.34 | 9.93 | 22 | 98617 | 2915 | 50503570 |
Muscle contracture | 13.32 | 9.93 | 14 | 98625 | 1193 | 50505292 |
Hyperthyroidism | 13.32 | 9.93 | 53 | 98586 | 12122 | 50494363 |
Diabetic gastroparesis | 13.22 | 9.93 | 7 | 98632 | 205 | 50506280 |
Eructation | 13.16 | 9.93 | 37 | 98602 | 7084 | 50499401 |
Catatonia | 13.12 | 9.93 | 25 | 98614 | 3711 | 50502774 |
Hypoaesthesia | 13.10 | 9.93 | 172 | 98467 | 127085 | 50379400 |
Generalised tonic-clonic seizure | 13.06 | 9.93 | 92 | 98547 | 26218 | 50480267 |
Dermatitis exfoliative | 12.92 | 9.93 | 30 | 98609 | 5112 | 50501373 |
Reflux gastritis | 12.91 | 9.93 | 12 | 98627 | 881 | 50505604 |
Palmar-plantar erythrodysaesthesia syndrome | 12.89 | 9.93 | 75 | 98564 | 20023 | 50486462 |
Myalgia | 12.81 | 9.93 | 168 | 98471 | 124151 | 50382334 |
Granulomatous liver disease | 12.75 | 9.93 | 11 | 98628 | 732 | 50505753 |
Economic problem | 12.74 | 9.93 | 17 | 98622 | 1865 | 50504620 |
Patent ductus arteriosus | 12.73 | 9.93 | 25 | 98614 | 3795 | 50502690 |
Bone density decreased | 12.67 | 9.93 | 3 | 98636 | 11072 | 50495413 |
Device dislocation | 12.62 | 9.93 | 14 | 98625 | 21532 | 50484953 |
Off label use | 12.60 | 9.93 | 777 | 97862 | 473649 | 50032836 |
Intentional self-injury | 12.49 | 9.93 | 16 | 98623 | 23096 | 50483389 |
Drug tolerance increased | 12.46 | 9.93 | 7 | 98632 | 231 | 50506254 |
Visual impairment | 12.38 | 9.93 | 80 | 98559 | 68195 | 50438290 |
Product quality issue | 12.35 | 9.93 | 26 | 98613 | 30832 | 50475653 |
Antiphospholipid syndrome | 12.32 | 9.93 | 15 | 98624 | 1502 | 50504983 |
Joint effusion | 12.26 | 9.93 | 5 | 98634 | 13016 | 50493469 |
Carpal tunnel syndrome | 12.26 | 9.93 | 9 | 98630 | 16884 | 50489601 |
Hiccups | 12.22 | 9.93 | 16 | 98623 | 1723 | 50504762 |
Gaze palsy | 12.18 | 9.93 | 14 | 98625 | 1319 | 50505166 |
Oesophageal ulcer | 12.17 | 9.93 | 25 | 98614 | 3920 | 50502565 |
Stridor | 12.12 | 9.93 | 22 | 98617 | 3147 | 50503338 |
Porphyria acute | 12.03 | 9.93 | 9 | 98630 | 488 | 50505997 |
Fibromyalgia | 12.01 | 9.93 | 46 | 98593 | 44932 | 50461553 |
Cachexia | 12.00 | 9.93 | 27 | 98612 | 4506 | 50501979 |
Nephritis allergic | 11.98 | 9.93 | 6 | 98633 | 156 | 50506329 |
Foot fracture | 11.83 | 9.93 | 13 | 98626 | 20078 | 50486407 |
Leukocytosis | 11.83 | 9.93 | 80 | 98559 | 22499 | 50483986 |
Non-cardiac chest pain | 11.81 | 9.93 | 31 | 98608 | 5701 | 50500784 |
Anaphylactic reaction | 11.81 | 9.93 | 159 | 98480 | 53896 | 50452589 |
Basal cell carcinoma | 11.78 | 9.93 | 17 | 98622 | 23339 | 50483146 |
Lip erosion | 11.77 | 9.93 | 11 | 98628 | 813 | 50505672 |
Intercepted product administration error | 11.77 | 9.93 | 5 | 98634 | 88 | 50506397 |
Porphyria | 11.71 | 9.93 | 6 | 98633 | 164 | 50506321 |
Abdominal tenderness | 11.71 | 9.93 | 36 | 98603 | 7244 | 50499241 |
Parkinson's disease | 11.68 | 9.93 | 13 | 98626 | 1182 | 50505303 |
Methaemoglobinaemia | 11.66 | 9.93 | 17 | 98622 | 2025 | 50504460 |
Drug dependence | 11.57 | 9.93 | 72 | 98567 | 19687 | 50486798 |
Vascular pain | 11.50 | 9.93 | 10 | 98629 | 673 | 50505812 |
Hyperpyrexia | 11.45 | 9.93 | 21 | 98618 | 3028 | 50503457 |
Chronic fatigue syndrome | 11.42 | 9.93 | 12 | 98627 | 1023 | 50505462 |
Tumour pain | 11.38 | 9.93 | 13 | 98626 | 1217 | 50505268 |
Prolactin-producing pituitary tumour | 11.37 | 9.93 | 5 | 98634 | 96 | 50506389 |
Lung infiltration | 11.36 | 9.93 | 54 | 98585 | 13339 | 50493146 |
Sciatica | 11.35 | 9.93 | 15 | 98624 | 21367 | 50485118 |
Myoclonus | 11.31 | 9.93 | 57 | 98582 | 14413 | 50492072 |
Premature delivery | 11.31 | 9.93 | 82 | 98557 | 23581 | 50482904 |
Head titubation | 11.25 | 9.93 | 10 | 98629 | 693 | 50505792 |
Restless arm syndrome | 11.20 | 9.93 | 4 | 98635 | 43 | 50506442 |
Therapy cessation | 11.20 | 9.93 | 21 | 98618 | 25990 | 50480495 |
Gastrointestinal necrosis | 11.19 | 9.93 | 19 | 98620 | 2579 | 50503906 |
Respiratory tract congestion | 11.06 | 9.93 | 7 | 98632 | 14192 | 50492293 |
Naevus haemorrhage | 11.05 | 9.93 | 5 | 98634 | 103 | 50506382 |
Device malfunction | 11.04 | 9.93 | 8 | 98631 | 15113 | 50491372 |
Sleep disorder | 10.97 | 9.93 | 66 | 98573 | 57217 | 50449268 |
Tracheal injury | 10.96 | 9.93 | 4 | 98635 | 46 | 50506439 |
Pregnancy | 10.95 | 9.93 | 26 | 98613 | 29551 | 50476934 |
Prescribed underdose | 10.93 | 9.93 | 9 | 98630 | 15940 | 50490545 |
Tooth disorder | 10.93 | 9.93 | 19 | 98620 | 24209 | 50482276 |
Urea urine increased | 10.92 | 9.93 | 3 | 98636 | 12 | 50506473 |
Pancreatitis haemorrhagic | 10.90 | 9.93 | 7 | 98632 | 296 | 50506189 |
Mucosal erosion | 10.90 | 9.93 | 13 | 98626 | 1274 | 50505211 |
Leukostasis syndrome | 10.88 | 9.93 | 4 | 98635 | 47 | 50506438 |
Blood pressure diastolic decreased | 10.86 | 9.93 | 10 | 98629 | 16771 | 50489714 |
Muscle twitching | 10.83 | 9.93 | 59 | 98580 | 15372 | 50491113 |
Foetal malpresentation | 10.83 | 9.93 | 5 | 98634 | 108 | 50506377 |
Amylase increased | 10.82 | 9.93 | 29 | 98610 | 5401 | 50501084 |
Urinary tract infection enterococcal | 10.75 | 9.93 | 18 | 98621 | 2416 | 50504069 |
Foot deformity | 10.69 | 9.93 | 13 | 98626 | 19197 | 50487288 |
Inflammation | 10.67 | 9.93 | 66 | 98573 | 56846 | 50449639 |
Urinary tract obstruction | 10.64 | 9.93 | 15 | 98624 | 1733 | 50504752 |
Circulatory collapse | 10.56 | 9.93 | 71 | 98568 | 19929 | 50486556 |
Epilepsy congenital | 10.55 | 9.93 | 3 | 98636 | 14 | 50506471 |
Platelet count decreased | 10.54 | 9.93 | 264 | 98375 | 100462 | 50406023 |
Musculoskeletal disorder | 10.47 | 9.93 | 11 | 98628 | 17338 | 50489147 |
COVID-19 | 10.46 | 9.93 | 51 | 98588 | 46611 | 50459874 |
Terminal ileitis | 10.39 | 9.93 | 9 | 98630 | 602 | 50505883 |
Gastrointestinal mucosal exfoliation | 10.39 | 9.93 | 5 | 98634 | 119 | 50506366 |
Opisthotonus | 10.37 | 9.93 | 7 | 98632 | 322 | 50506163 |
Hypophosphataemia | 10.33 | 9.93 | 38 | 98601 | 8376 | 50498109 |
Peritoneal perforation | 10.31 | 9.93 | 5 | 98634 | 121 | 50506364 |
Electrocardiogram change | 10.31 | 9.93 | 9 | 98630 | 609 | 50505876 |
Sinus arrhythmia | 10.25 | 9.93 | 13 | 98626 | 1356 | 50505129 |
Proctalgia | 10.25 | 9.93 | 27 | 98612 | 4976 | 50501509 |
Muscle spasticity | 10.25 | 9.93 | 11 | 98628 | 17173 | 50489312 |
Systemic infection | 10.24 | 9.93 | 17 | 98622 | 2266 | 50504219 |
Nephrocalcinosis | 10.22 | 9.93 | 11 | 98628 | 963 | 50505522 |
Sinus tachycardia | 10.21 | 9.93 | 74 | 98565 | 21280 | 50485205 |
Aspartate aminotransferase increased | 10.21 | 9.93 | 211 | 98428 | 77787 | 50428698 |
Thoracic operation | 10.20 | 9.93 | 5 | 98634 | 124 | 50506361 |
Metastatic malignant melanoma | 10.17 | 9.93 | 12 | 98627 | 1162 | 50505323 |
Flail chest | 10.12 | 9.93 | 4 | 98635 | 58 | 50506427 |
Motion sickness | 10.10 | 9.93 | 10 | 98629 | 794 | 50505691 |
Febrile infection | 10.09 | 9.93 | 12 | 98627 | 1172 | 50505313 |
Ultrasound abdomen abnormal | 10.06 | 9.93 | 4 | 98635 | 59 | 50506426 |
Subacute combined cord degeneration | 10.04 | 9.93 | 6 | 98633 | 223 | 50506262 |
Bundle branch block | 10.02 | 9.93 | 10 | 98629 | 802 | 50505683 |
Abdominal mass | 9.99 | 9.93 | 18 | 98621 | 2561 | 50503924 |
Dysuria | 9.97 | 9.93 | 92 | 98547 | 28412 | 50478073 |
MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
---|---|---|---|---|---|---|
Febrile neutropenia | 359.70 | 10.22 | 733 | 58576 | 111507 | 29403711 |
Vomiting | 247.20 | 10.22 | 958 | 58351 | 211302 | 29303916 |
Drug ineffective | 227.29 | 10.22 | 237 | 59072 | 362933 | 29152285 |
Nausea | 136.27 | 10.22 | 1018 | 58291 | 288237 | 29226981 |
General physical health deterioration | 114.95 | 10.22 | 459 | 58850 | 102398 | 29412820 |
Dehydration | 91.28 | 10.22 | 463 | 58846 | 114285 | 29400933 |
Drug abuse | 81.78 | 10.22 | 29 | 59280 | 79854 | 29435364 |
Pyrexia | 81.28 | 10.22 | 907 | 58402 | 286715 | 29228503 |
Decreased appetite | 79.46 | 10.22 | 531 | 58778 | 144811 | 29370407 |
Product dose omission issue | 71.88 | 10.22 | 53 | 59256 | 96330 | 29418888 |
Serotonin syndrome | 70.16 | 10.22 | 126 | 59183 | 17386 | 29497832 |
Dystonia | 65.48 | 10.22 | 89 | 59220 | 9660 | 29505558 |
Impaired gastric emptying | 60.90 | 10.22 | 50 | 59259 | 3020 | 29512198 |
Constipation | 60.49 | 10.22 | 414 | 58895 | 113746 | 29401472 |
Neutropenic sepsis | 58.42 | 10.22 | 93 | 59216 | 11634 | 29503584 |
Neutropenia | 57.99 | 10.22 | 457 | 58852 | 131254 | 29383964 |
Drug intolerance | 52.24 | 10.22 | 16 | 59293 | 48363 | 29466855 |
Completed suicide | 49.53 | 10.22 | 65 | 59244 | 90181 | 29425037 |
Malignant neoplasm progression | 49.15 | 10.22 | 284 | 59025 | 73575 | 29441643 |
Thrombocytopenia | 43.42 | 10.22 | 437 | 58872 | 134386 | 29380832 |
Therapeutic product effect incomplete | 40.66 | 10.22 | 14 | 59295 | 39291 | 29475927 |
Meconium abnormal | 37.92 | 10.22 | 11 | 59298 | 54 | 29515164 |
Pneumonitis | 37.77 | 10.22 | 133 | 59176 | 27911 | 29487307 |
Alveolar lung disease | 37.03 | 10.22 | 17 | 59292 | 352 | 29514866 |
Peripheral swelling | 36.96 | 10.22 | 44 | 59265 | 63695 | 29451523 |
Aplastic anaemia | 36.64 | 10.22 | 59 | 59250 | 7451 | 29507767 |
Death | 36.42 | 10.22 | 476 | 58833 | 341608 | 29173610 |
Hypokalaemia | 35.33 | 10.22 | 196 | 59113 | 50007 | 29465211 |
Sepsis | 35.24 | 10.22 | 439 | 58870 | 142243 | 29372975 |
Therapeutic product effect decreased | 35.09 | 10.22 | 8 | 59301 | 29443 | 29485775 |
Genital erythema | 34.09 | 10.22 | 13 | 59296 | 165 | 29515053 |
Off label use | 33.31 | 10.22 | 415 | 58894 | 300385 | 29214833 |
Pulmonary interstitial emphysema syndrome | 33.25 | 10.22 | 17 | 59292 | 449 | 29514769 |
Oesophagitis | 32.41 | 10.22 | 73 | 59236 | 11850 | 29503368 |
Neuroleptic malignant syndrome | 32.38 | 10.22 | 88 | 59221 | 16060 | 29499158 |
Treatment failure | 32.08 | 10.22 | 17 | 59292 | 36922 | 29478296 |
Abdominal pain | 31.53 | 10.22 | 412 | 58897 | 134945 | 29380273 |
Hypophagia | 30.74 | 10.22 | 102 | 59207 | 20770 | 29494448 |
Toxicity to various agents | 30.20 | 10.22 | 214 | 59095 | 173447 | 29341771 |
Arthralgia | 30.02 | 10.22 | 161 | 59148 | 139456 | 29375762 |
Hyponatraemia | 29.88 | 10.22 | 235 | 59074 | 67398 | 29447820 |
Diarrhoea | 29.54 | 10.22 | 874 | 58435 | 331824 | 29183394 |
Mesothelioma | 29.28 | 10.22 | 15 | 59294 | 398 | 29514820 |
Psoriasis | 29.24 | 10.22 | 14 | 59295 | 32213 | 29483005 |
Joint swelling | 29.05 | 10.22 | 34 | 59275 | 49596 | 29465622 |
Weight increased | 27.95 | 10.22 | 71 | 59238 | 76596 | 29438622 |
Foetal exposure during pregnancy | 27.80 | 10.22 | 138 | 59171 | 33729 | 29481489 |
Rheumatoid arthritis | 27.62 | 10.22 | 15 | 59294 | 32137 | 29483081 |
Malnutrition | 27.55 | 10.22 | 65 | 59244 | 10876 | 29504342 |
Toxic epidermal necrolysis | 26.99 | 10.22 | 89 | 59220 | 18064 | 29497154 |
Premature baby | 26.85 | 10.22 | 86 | 59223 | 17194 | 29498024 |
Pneumonia | 26.77 | 10.22 | 835 | 58474 | 319337 | 29195881 |
Ileus | 25.47 | 10.22 | 75 | 59234 | 14327 | 29500891 |
Laparotomy | 25.31 | 10.22 | 12 | 59297 | 268 | 29514950 |
Necrotising enterocolitis neonatal | 25.26 | 10.22 | 11 | 59298 | 200 | 29515018 |
Blood pressure fluctuation | 24.52 | 10.22 | 5 | 59304 | 19889 | 29495329 |
Hepatic failure | 24.18 | 10.22 | 126 | 59183 | 31386 | 29483832 |
Condition aggravated | 24.11 | 10.22 | 183 | 59126 | 146112 | 29369106 |
Mucosal inflammation | 24.01 | 10.22 | 126 | 59183 | 31469 | 29483749 |
Haematopoietic stem cell mobilisation | 23.96 | 10.22 | 10 | 59299 | 163 | 29515055 |
Intentional product use issue | 23.93 | 10.22 | 30 | 59279 | 42468 | 29472750 |
Pleural effusion | 23.55 | 10.22 | 234 | 59075 | 71674 | 29443544 |
Leukopenia | 23.39 | 10.22 | 190 | 59119 | 55013 | 29460205 |
Hyperthermia malignant | 23.38 | 10.22 | 23 | 59286 | 1761 | 29513457 |
Colitis | 23.32 | 10.22 | 124 | 59185 | 31124 | 29484094 |
Gastrointestinal hypermotility | 23.20 | 10.22 | 9 | 59300 | 120 | 29515098 |
Extrapyramidal disorder | 22.70 | 10.22 | 60 | 59249 | 10771 | 29504447 |
Impetigo | 22.52 | 10.22 | 17 | 59292 | 908 | 29514310 |
Enteritis | 22.41 | 10.22 | 45 | 59264 | 6746 | 29508472 |
Long QT syndrome | 22.25 | 10.22 | 25 | 59284 | 2233 | 29512985 |
Intentional product misuse | 22.22 | 10.22 | 22 | 59287 | 34639 | 29480579 |
Delirium | 22.09 | 10.22 | 145 | 59164 | 39252 | 29475966 |
Anaemia | 22.08 | 10.22 | 543 | 58766 | 200408 | 29314810 |
Intentional overdose | 21.90 | 10.22 | 27 | 59282 | 38501 | 29476717 |
Drug resistance | 21.72 | 10.22 | 8 | 59301 | 21532 | 29493686 |
Hiccups | 21.65 | 10.22 | 52 | 59257 | 8801 | 29506417 |
Congenital pneumonia | 21.54 | 10.22 | 8 | 59301 | 94 | 29515124 |
Cytokine release syndrome | 21.03 | 10.22 | 66 | 59243 | 13053 | 29502165 |
Conjunctival irritation | 21.02 | 10.22 | 8 | 59301 | 101 | 29515117 |
Toxic encephalopathy | 20.83 | 10.22 | 35 | 59274 | 4577 | 29510641 |
Electrocardiogram QT prolonged | 20.26 | 10.22 | 133 | 59176 | 36004 | 29479214 |
Cardiac failure congestive | 20.17 | 10.22 | 82 | 59227 | 76499 | 29438719 |
Feeling abnormal | 20.16 | 10.22 | 50 | 59259 | 54395 | 29460823 |
Post concussion syndrome | 20.08 | 10.22 | 8 | 59301 | 115 | 29515103 |
Pseudomonal sepsis | 19.97 | 10.22 | 27 | 59282 | 2915 | 29512303 |
Non-small cell lung cancer | 19.69 | 10.22 | 27 | 59282 | 2954 | 29512264 |
Talipes | 19.67 | 10.22 | 21 | 59288 | 1771 | 29513447 |
Erectile dysfunction | 19.35 | 10.22 | 6 | 59303 | 18003 | 29497215 |
Product use issue | 19.24 | 10.22 | 47 | 59262 | 51397 | 29463821 |
Rash maculo-papular | 19.24 | 10.22 | 98 | 59211 | 24191 | 29491027 |
Hepatocellular injury | 19.19 | 10.22 | 89 | 59220 | 21154 | 29494064 |
Jaundice | 19.04 | 10.22 | 112 | 59197 | 29184 | 29486034 |
Lower respiratory tract infection | 18.99 | 10.22 | 104 | 59205 | 26398 | 29488820 |
Urticaria | 18.87 | 10.22 | 52 | 59257 | 54608 | 29460610 |
Tardive dyskinesia | 18.76 | 10.22 | 36 | 59273 | 5222 | 29509996 |
Electrocardiogram QT shortened | 18.60 | 10.22 | 8 | 59301 | 141 | 29515077 |
Vascular access site occlusion | 18.53 | 10.22 | 6 | 59303 | 45 | 29515173 |
Suicide attempt | 18.26 | 10.22 | 25 | 59284 | 34085 | 29481133 |
Ascites | 17.71 | 10.22 | 130 | 59179 | 36489 | 29478729 |
Myocardial infarction | 17.67 | 10.22 | 139 | 59170 | 110157 | 29405061 |
Vocal cord inflammation | 17.48 | 10.22 | 6 | 59303 | 55 | 29515163 |
Dysphagia | 17.14 | 10.22 | 177 | 59132 | 54749 | 29460469 |
Laryngeal cancer metastatic | 17.11 | 10.22 | 6 | 59303 | 59 | 29515159 |
Heart rate decreased | 16.92 | 10.22 | 15 | 59294 | 24897 | 29490321 |
Hyperbilirubinaemia | 16.91 | 10.22 | 67 | 59242 | 14867 | 29500351 |
Wrong technique in product usage process | 16.85 | 10.22 | 23 | 59286 | 31405 | 29483813 |
Blood alkaline phosphatase increased | 16.81 | 10.22 | 106 | 59203 | 28300 | 29486918 |
Pulmonary embolism | 16.57 | 10.22 | 230 | 59079 | 76304 | 29438914 |
Failure to thrive | 16.54 | 10.22 | 43 | 59266 | 7641 | 29507577 |
Cytokine storm | 16.50 | 10.22 | 12 | 59297 | 605 | 29514613 |
Renal vasculitis | 16.35 | 10.22 | 7 | 59302 | 122 | 29515096 |
Tumour pain | 16.27 | 10.22 | 14 | 59295 | 902 | 29514316 |
Wheezing | 16.20 | 10.22 | 26 | 59283 | 33214 | 29482004 |
Chemotherapeutic drug level increased | 15.98 | 10.22 | 8 | 59301 | 202 | 29515016 |
Arthropathy | 15.86 | 10.22 | 12 | 59297 | 21542 | 29493676 |
Diffuse alveolar damage | 15.81 | 10.22 | 20 | 59289 | 2023 | 29513195 |
Spleen congestion | 15.70 | 10.22 | 9 | 59300 | 300 | 29514918 |
Bacterial tracheitis | 15.64 | 10.22 | 3 | 59306 | 0 | 29515218 |
Ileus paralytic | 15.35 | 10.22 | 33 | 59276 | 5190 | 29510028 |
Symmetrical drug-related intertriginous and flexural exanthema | 15.32 | 10.22 | 8 | 59301 | 221 | 29514997 |
Abdominal compartment syndrome | 15.26 | 10.22 | 13 | 59296 | 826 | 29514392 |
Acute abdomen | 14.96 | 10.22 | 18 | 59291 | 1729 | 29513489 |
Hospitalisation | 14.95 | 10.22 | 45 | 59264 | 45943 | 29469275 |
Hypoalbuminaemia | 14.85 | 10.22 | 50 | 59259 | 10255 | 29504963 |
Subileus | 14.74 | 10.22 | 23 | 59286 | 2827 | 29512391 |
Lymphoid tissue hypoplasia | 14.61 | 10.22 | 7 | 59302 | 160 | 29515058 |
Thymus hypoplasia | 14.61 | 10.22 | 7 | 59302 | 160 | 29515058 |
Chills | 14.52 | 10.22 | 212 | 59097 | 71088 | 29444130 |
Gait disturbance | 14.44 | 10.22 | 87 | 59222 | 73262 | 29441956 |
Disturbance in attention | 14.43 | 10.22 | 13 | 59296 | 21411 | 29493807 |
Neutrophil count decreased | 14.36 | 10.22 | 142 | 59167 | 43425 | 29471793 |
Septic shock | 14.35 | 10.22 | 190 | 59119 | 62370 | 29452848 |
Musculoskeletal stiffness | 14.18 | 10.22 | 34 | 59275 | 37424 | 29477794 |
Seborrhoeic dermatitis | 14.17 | 10.22 | 16 | 59293 | 1437 | 29513781 |
Product use in unapproved indication | 14.14 | 10.22 | 109 | 59200 | 86766 | 29428452 |
Klebsiella bacteraemia | 14.00 | 10.22 | 14 | 59295 | 1093 | 29514125 |
Blood bilirubin increased | 14.00 | 10.22 | 116 | 59193 | 33777 | 29481441 |
Pulmonary sepsis | 13.96 | 10.22 | 18 | 59291 | 1856 | 29513362 |
Psoriatic arthropathy | 13.92 | 10.22 | 6 | 59303 | 14685 | 29500533 |
Dyskinesia | 13.89 | 10.22 | 78 | 59231 | 19983 | 29495235 |
Fall | 13.88 | 10.22 | 261 | 59048 | 176917 | 29338301 |
Neutropenic infection | 13.79 | 10.22 | 15 | 59294 | 1292 | 29513926 |
Blood creatine phosphokinase increased | 13.78 | 10.22 | 39 | 59270 | 40605 | 29474613 |
Pericardial effusion | 13.73 | 10.22 | 81 | 59228 | 21127 | 29494091 |
Diabetic gastroparesis | 13.64 | 10.22 | 6 | 59303 | 112 | 29515106 |
Phaeochromocytoma crisis | 13.60 | 10.22 | 5 | 59304 | 57 | 29515161 |
Asthma | 13.40 | 10.22 | 30 | 59279 | 33819 | 29481399 |
Loss of personal independence in daily activities | 13.26 | 10.22 | 19 | 59290 | 25421 | 29489797 |
Headache | 13.11 | 10.22 | 258 | 59051 | 173749 | 29341469 |
Maternal drugs affecting foetus | 13.09 | 10.22 | 26 | 59283 | 3867 | 29511351 |
Device related infection | 13.03 | 10.22 | 64 | 59245 | 15572 | 29499646 |
Intestinal ischaemia | 12.95 | 10.22 | 36 | 59273 | 6656 | 29508562 |
Dyschezia | 12.94 | 10.22 | 14 | 59295 | 1199 | 29514019 |
Synovitis | 12.89 | 10.22 | 3 | 59306 | 10887 | 29504331 |
Scan abnormal | 12.72 | 10.22 | 4 | 59305 | 27 | 29515191 |
Underdose | 12.67 | 10.22 | 4 | 59305 | 11865 | 29503353 |
Performance status decreased | 12.66 | 10.22 | 25 | 59284 | 3702 | 29511516 |
Injection site pain | 12.64 | 10.22 | 29 | 59280 | 32417 | 29482801 |
Swelling | 12.60 | 10.22 | 33 | 59276 | 35250 | 29479968 |
Tumour lysis syndrome | 12.42 | 10.22 | 58 | 59251 | 13826 | 29501392 |
Contraindicated product administered | 12.40 | 10.22 | 11 | 59298 | 18255 | 29496963 |
Ventricular septal defect | 12.39 | 10.22 | 24 | 59285 | 3505 | 29511713 |
Blood aluminium increased | 12.36 | 10.22 | 3 | 59306 | 6 | 29515212 |
Aphthous ulcer | 12.30 | 10.22 | 26 | 59283 | 4042 | 29511176 |
Cholangitis | 12.15 | 10.22 | 38 | 59271 | 7499 | 29507719 |
Cachexia | 12.13 | 10.22 | 34 | 59275 | 6315 | 29508903 |
Restlessness | 12.10 | 10.22 | 81 | 59228 | 22064 | 29493154 |
Immune-mediated hepatitis | 11.90 | 10.22 | 15 | 59294 | 1512 | 29513706 |
Type III immune complex mediated reaction | 11.85 | 10.22 | 7 | 59302 | 247 | 29514971 |
Blood pressure increased | 11.82 | 10.22 | 93 | 59216 | 73710 | 29441508 |
Hygroma colli | 11.82 | 10.22 | 4 | 59305 | 35 | 29515183 |
Platelet count decreased | 11.81 | 10.22 | 284 | 59025 | 104388 | 29410830 |
Therapy non-responder | 11.75 | 10.22 | 28 | 59281 | 30883 | 29484335 |
Acute kidney injury | 11.54 | 10.22 | 646 | 58663 | 264621 | 29250597 |
Product quality issue | 11.50 | 10.22 | 9 | 59300 | 15886 | 29499332 |
Herpes zoster reactivation | 11.46 | 10.22 | 7 | 59302 | 263 | 29514955 |
Retching | 11.43 | 10.22 | 32 | 59277 | 5941 | 29509277 |
Stress | 11.25 | 10.22 | 16 | 59293 | 21474 | 29493744 |
Body temperature increased | 11.20 | 10.22 | 58 | 59251 | 14407 | 29500811 |
COVID-19 | 11.17 | 10.22 | 36 | 59273 | 35978 | 29479240 |
Stress cardiomyopathy | 11.17 | 10.22 | 15 | 59294 | 1609 | 29513609 |
Spinal cord injury thoracic | 11.14 | 10.22 | 5 | 59304 | 98 | 29515120 |
Sopor | 11.12 | 10.22 | 4 | 59305 | 10930 | 29504288 |
Renal dysplasia | 11.07 | 10.22 | 6 | 59303 | 179 | 29515039 |
Drug clearance decreased | 11.07 | 10.22 | 14 | 59295 | 1416 | 29513802 |
Hepatitis fulminant | 11 | 10.22 | 23 | 59286 | 3548 | 29511670 |
Gastrointestinal malformation | 10.92 | 10.22 | 4 | 59305 | 45 | 29515173 |
Colorectal cancer metastatic | 10.84 | 10.22 | 9 | 59300 | 552 | 29514666 |
Oesophageal hypomotility | 10.84 | 10.22 | 3 | 59306 | 12 | 29515206 |
Congenital nasal septum deviation | 10.84 | 10.22 | 3 | 59306 | 12 | 29515206 |
Lenticulostriatal vasculopathy | 10.84 | 10.22 | 3 | 59306 | 12 | 29515206 |
Rheumatoid nodule | 10.80 | 10.22 | 17 | 59292 | 2105 | 29513113 |
Hypoaesthesia | 10.74 | 10.22 | 63 | 59246 | 53404 | 29461814 |
Therapy cessation | 10.70 | 10.22 | 8 | 59301 | 14454 | 29500764 |
Eastern Cooperative Oncology Group performance status worsened | 10.68 | 10.22 | 10 | 59299 | 720 | 29514498 |
Skeletal dysplasia | 10.61 | 10.22 | 5 | 59304 | 110 | 29515108 |
Cholestasis | 10.61 | 10.22 | 82 | 59227 | 23380 | 29491838 |
Buttock injury | 10.55 | 10.22 | 4 | 59305 | 50 | 29515168 |
Calcium ionised increased | 10.47 | 10.22 | 3 | 59306 | 14 | 29515204 |
Bacteraemia | 10.34 | 10.22 | 62 | 59247 | 16261 | 29498957 |
Restrictive cardiomyopathy | 10.30 | 10.22 | 9 | 59300 | 592 | 29514626 |
Generalised oedema | 10.25 | 10.22 | 47 | 59262 | 11118 | 29504100 |
MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
---|---|---|---|---|---|---|
Febrile neutropenia | 641.40 | 9.72 | 1290 | 133468 | 186367 | 64177607 |
Vomiting | 522.20 | 9.72 | 2403 | 132355 | 548714 | 63815260 |
Drug ineffective | 489.84 | 9.72 | 625 | 134133 | 839622 | 63524352 |
Nausea | 267.30 | 9.72 | 2656 | 132102 | 783144 | 63580830 |
Drug intolerance | 238.10 | 9.72 | 51 | 134707 | 187941 | 64176033 |
Joint swelling | 209.27 | 9.72 | 94 | 134664 | 215288 | 64148686 |
Rheumatoid arthritis | 203.14 | 9.72 | 47 | 134711 | 164247 | 64199727 |
General physical health deterioration | 201.77 | 9.72 | 904 | 133854 | 203521 | 64160453 |
Neutropenic sepsis | 193.53 | 9.72 | 241 | 134517 | 23031 | 64340943 |
Pyrexia | 188.63 | 9.72 | 1887 | 132871 | 556757 | 63807217 |
Hypokalaemia | 171.84 | 9.72 | 603 | 134155 | 121300 | 64242674 |
Dehydration | 171.02 | 9.72 | 899 | 133859 | 215864 | 64148110 |
Synovitis | 166.87 | 9.72 | 10 | 134748 | 99080 | 64264894 |
Decreased appetite | 165.17 | 9.72 | 1079 | 133679 | 280210 | 64083764 |
Therapeutic product effect decreased | 164.15 | 9.72 | 23 | 134735 | 115328 | 64248646 |
Completed suicide | 161.27 | 9.72 | 139 | 134619 | 224275 | 64139699 |
Dystonia | 161.11 | 9.72 | 198 | 134560 | 18667 | 64345307 |
Arthralgia | 149.65 | 9.72 | 452 | 134306 | 441808 | 63922166 |
Neutropenia | 146.64 | 9.72 | 929 | 133829 | 238695 | 64125279 |
Constipation | 145.25 | 9.72 | 897 | 133861 | 228440 | 64135534 |
Arthropathy | 141.03 | 9.72 | 39 | 134719 | 120928 | 64243046 |
Contraindicated product administered | 134.95 | 9.72 | 30 | 134728 | 107799 | 64256175 |
Weight increased | 130.54 | 9.72 | 152 | 134606 | 213196 | 64150778 |
Serotonin syndrome | 127.81 | 9.72 | 265 | 134493 | 39017 | 64324957 |
Product dose omission issue | 125.45 | 9.72 | 133 | 134625 | 194614 | 64169360 |
Thrombocytopenia | 119.01 | 9.72 | 838 | 133920 | 222963 | 64141011 |
Hand deformity | 113.25 | 9.72 | 4 | 134754 | 62767 | 64301207 |
Diarrhoea | 111.09 | 9.72 | 2121 | 132637 | 720583 | 63643391 |
Swelling | 109.37 | 9.72 | 104 | 134654 | 160114 | 64203860 |
Malignant neoplasm progression | 107.36 | 9.72 | 494 | 134264 | 112377 | 64251597 |
Mucosal inflammation | 103.63 | 9.72 | 327 | 134431 | 62257 | 64301717 |
Abdominal pain | 103.48 | 9.72 | 1052 | 133706 | 311323 | 64052651 |
Impaired gastric emptying | 101.59 | 9.72 | 108 | 134650 | 8696 | 64355278 |
Hyponatraemia | 100.70 | 9.72 | 591 | 134167 | 147748 | 64216226 |
Injection site pain | 97.10 | 9.72 | 56 | 134702 | 111352 | 64252622 |
Toxic epidermal necrolysis | 92.10 | 9.72 | 225 | 134533 | 36941 | 64327033 |
Therapeutic product effect incomplete | 90.21 | 9.72 | 52 | 134706 | 103430 | 64260544 |
Sinusitis | 89.18 | 9.72 | 104 | 134654 | 145824 | 64218150 |
Systemic lupus erythematosus | 86.82 | 9.72 | 27 | 134731 | 77585 | 64286389 |
Peripheral swelling | 86.49 | 9.72 | 193 | 134565 | 208960 | 64155014 |
Phaeochromocytoma crisis | 86.00 | 9.72 | 30 | 134728 | 277 | 64363697 |
Torsade de pointes | 81.36 | 9.72 | 137 | 134621 | 17226 | 64346748 |
Pulmonary embolism | 80.65 | 9.72 | 553 | 134205 | 145803 | 64218171 |
Nasopharyngitis | 79.38 | 9.72 | 183 | 134575 | 195890 | 64168084 |
Hypomagnesaemia | 74.91 | 9.72 | 209 | 134549 | 37167 | 64326807 |
Anaemia | 73.27 | 9.72 | 1154 | 133604 | 377526 | 63986448 |
Psoriasis | 73.24 | 9.72 | 29 | 134729 | 71674 | 64292300 |
Product use issue | 70.35 | 9.72 | 131 | 134627 | 151584 | 64212390 |
Extrapyramidal disorder | 69.66 | 9.72 | 137 | 134621 | 19415 | 64344559 |
Musculoskeletal stiffness | 68.82 | 9.72 | 94 | 134664 | 123112 | 64240862 |
Aplastic anaemia | 68.12 | 9.72 | 112 | 134646 | 13808 | 64350166 |
Sepsis | 67.43 | 9.72 | 757 | 134001 | 229584 | 64134390 |
Treatment failure | 66.39 | 9.72 | 88 | 134670 | 116728 | 64247246 |
Glossodynia | 64.73 | 9.72 | 27 | 134731 | 64669 | 64299305 |
Atelectasis | 64.32 | 9.72 | 162 | 134596 | 27104 | 64336870 |
Abdominal discomfort | 63.91 | 9.72 | 183 | 134575 | 182139 | 64181835 |
Blood pressure fluctuation | 63.74 | 9.72 | 15 | 134743 | 51856 | 64312118 |
Neutrophil count decreased | 59.26 | 9.72 | 318 | 134440 | 76878 | 64287096 |
Leukopenia | 58.42 | 9.72 | 387 | 134371 | 100855 | 64263119 |
Ileus | 57.93 | 9.72 | 140 | 134618 | 22826 | 64341148 |
Wound | 57.81 | 9.72 | 45 | 134713 | 76432 | 64287542 |
Fall | 57.50 | 9.72 | 575 | 134183 | 416251 | 63947723 |
Electrocardiogram QT prolonged | 56.78 | 9.72 | 321 | 134437 | 79127 | 64284847 |
Neovascularisation | 54.50 | 9.72 | 32 | 134726 | 1071 | 64362903 |
Psoriatic arthropathy | 54.22 | 9.72 | 12 | 134746 | 43269 | 64320705 |
Colitis | 53.69 | 9.72 | 254 | 134504 | 58420 | 64305554 |
Pericarditis | 53.64 | 9.72 | 32 | 134726 | 62484 | 64301490 |
Oesophagitis | 52.58 | 9.72 | 130 | 134628 | 21500 | 64342474 |
Pneumonitis | 52.04 | 9.72 | 226 | 134532 | 50139 | 64313835 |
Hepatic enzyme increased | 51.99 | 9.72 | 122 | 134636 | 129821 | 64234153 |
Phaeochromocytoma | 51.52 | 9.72 | 25 | 134733 | 564 | 64363410 |
Neuroleptic malignant syndrome | 51.30 | 9.72 | 141 | 134617 | 24855 | 64339119 |
Arthritis | 50.90 | 9.72 | 60 | 134698 | 83754 | 64280220 |
Injection site bruising | 50.00 | 9.72 | 8 | 134750 | 36365 | 64327609 |
Cholecystitis chronic | 49.93 | 9.72 | 78 | 134680 | 9209 | 64354765 |
Injection site erythema | 49.41 | 9.72 | 45 | 134713 | 70755 | 64293219 |
Pneumonia | 49.31 | 9.72 | 1523 | 133235 | 558053 | 63805921 |
Condition aggravated | 49.19 | 9.72 | 519 | 134239 | 371907 | 63992067 |
Parkinsonism | 49.15 | 9.72 | 99 | 134659 | 14274 | 64349700 |
Computerised tomogram thorax abnormal | 48.39 | 9.72 | 37 | 134721 | 1932 | 64362042 |
Hepatocellular injury | 48.29 | 9.72 | 205 | 134553 | 45030 | 64318944 |
Blood pressure increased | 47.65 | 9.72 | 192 | 134566 | 172360 | 64191614 |
Drug abuse | 47.01 | 9.72 | 132 | 134626 | 132242 | 64231732 |
Duodenal ulcer perforation | 46.74 | 9.72 | 8 | 134750 | 34617 | 64329357 |
Rash maculo-papular | 45.55 | 9.72 | 207 | 134551 | 46819 | 64317155 |
Pleural effusion | 45.08 | 9.72 | 433 | 134325 | 126126 | 64237848 |
Pain | 44.19 | 9.72 | 853 | 133905 | 552658 | 63811316 |
Tardive dyskinesia | 43.77 | 9.72 | 73 | 134685 | 9105 | 64354869 |
Injection site swelling | 43.44 | 9.72 | 16 | 134742 | 41337 | 64322637 |
Heart rate decreased | 43.43 | 9.72 | 31 | 134727 | 55036 | 64308938 |
Malnutrition | 43.41 | 9.72 | 112 | 134646 | 19013 | 64344961 |
Sleep disorder due to general medical condition, insomnia type | 43.18 | 9.72 | 3 | 134755 | 26267 | 64337707 |
Acute kidney injury | 43.13 | 9.72 | 1236 | 133522 | 448004 | 63915970 |
Restlessness | 43.01 | 9.72 | 181 | 134577 | 39604 | 64324370 |
Wrong technique in product usage process | 42.21 | 9.72 | 44 | 134714 | 64930 | 64299044 |
Subileus | 42.10 | 9.72 | 52 | 134706 | 4925 | 64359049 |
Discomfort | 41.92 | 9.72 | 65 | 134693 | 80813 | 64283161 |
Helicobacter infection | 41.74 | 9.72 | 14 | 134744 | 38348 | 64325626 |
Contusion | 41.69 | 9.72 | 112 | 134646 | 113853 | 64250121 |
Toxicity to various agents | 41.21 | 9.72 | 524 | 134234 | 362989 | 64000985 |
Injection site pruritus | 40.82 | 9.72 | 14 | 134744 | 37812 | 64326162 |
Pain in extremity | 40.55 | 9.72 | 421 | 134337 | 302664 | 64061310 |
Therapeutic response decreased | 40.35 | 9.72 | 30 | 134728 | 52158 | 64311816 |
Hypophagia | 39.65 | 9.72 | 176 | 134582 | 39411 | 64324563 |
Intentional product use issue | 39.38 | 9.72 | 88 | 134670 | 95276 | 64268698 |
Impaired healing | 39.23 | 9.72 | 41 | 134717 | 60432 | 64303542 |
Injection site reaction | 38.49 | 9.72 | 25 | 134733 | 46639 | 64317335 |
Cytokine release syndrome | 38.36 | 9.72 | 113 | 134645 | 20716 | 64343258 |
Neuropathy peripheral | 37.94 | 9.72 | 394 | 134364 | 117131 | 64246843 |
Cholestasis | 37.29 | 9.72 | 189 | 134569 | 44683 | 64319291 |
Osteoarthritis | 36.70 | 9.72 | 47 | 134711 | 63289 | 64300685 |
Septic shock | 36.69 | 9.72 | 359 | 134399 | 105078 | 64258896 |
Red blood cell sedimentation rate increased | 36.51 | 9.72 | 10 | 134748 | 31225 | 64332749 |
Intentional overdose | 36.32 | 9.72 | 84 | 134674 | 89860 | 64274114 |
Long QT syndrome | 36.13 | 9.72 | 49 | 134709 | 5090 | 64358884 |
Asthma | 36.04 | 9.72 | 92 | 134666 | 95133 | 64268841 |
Hiccups | 35.21 | 9.72 | 63 | 134695 | 8313 | 64355661 |
Mixed liver injury | 35.15 | 9.72 | 50 | 134708 | 5431 | 64358543 |
Gastritis | 35.06 | 9.72 | 179 | 134579 | 42439 | 64321535 |
Urticaria | 34.61 | 9.72 | 174 | 134584 | 147143 | 64216831 |
Drug resistance | 34.55 | 9.72 | 15 | 134743 | 35087 | 64328887 |
Genital erythema | 33.99 | 9.72 | 14 | 134744 | 211 | 64363763 |
Dysphagia | 33.96 | 9.72 | 357 | 134401 | 106455 | 64257519 |
Hepatic failure | 33.31 | 9.72 | 214 | 134544 | 55180 | 64308794 |
Knee arthroplasty | 32.79 | 9.72 | 8 | 134750 | 26991 | 64336983 |
Aplasia | 32.76 | 9.72 | 55 | 134703 | 6898 | 64357076 |
Pulmonary interstitial emphysema syndrome | 32.70 | 9.72 | 17 | 134741 | 446 | 64363528 |
Oculogyric crisis | 32.64 | 9.72 | 33 | 134725 | 2505 | 64361469 |
Haematemesis | 32.33 | 9.72 | 188 | 134570 | 46811 | 64317163 |
Off label use | 31.61 | 9.72 | 1045 | 133713 | 631761 | 63732213 |
Loss of personal independence in daily activities | 31.46 | 9.72 | 65 | 134693 | 72389 | 64291585 |
Gastroenteritis | 31.21 | 9.72 | 134 | 134624 | 29577 | 64334397 |
Febrile bone marrow aplasia | 30.98 | 9.72 | 71 | 134687 | 11184 | 64352790 |
Small intestinal obstruction | 30.94 | 9.72 | 114 | 134644 | 23459 | 64340515 |
Device expulsion | 30.56 | 9.72 | 4 | 134754 | 21132 | 64342842 |
Alveolar lung disease | 30.33 | 9.72 | 17 | 134741 | 520 | 64363454 |
Renal ischaemia | 30.30 | 9.72 | 22 | 134736 | 1061 | 64362913 |
Ascites | 29.91 | 9.72 | 227 | 134531 | 61774 | 64302200 |
Suicide attempt | 29.74 | 9.72 | 65 | 134693 | 70942 | 64293032 |
C-reactive protein abnormal | 29.25 | 9.72 | 12 | 134746 | 29035 | 64334939 |
Duodenal stenosis | 28.93 | 9.72 | 18 | 134740 | 670 | 64363304 |
Headache | 28.92 | 9.72 | 864 | 133894 | 528603 | 63835371 |
Peripheral circulatory failure | 28.86 | 9.72 | 18 | 134740 | 673 | 64363301 |
Akathisia | 28.85 | 9.72 | 70 | 134688 | 11440 | 64352534 |
Gait disturbance | 28.73 | 9.72 | 226 | 134532 | 171929 | 64192045 |
Electrolyte imbalance | 28.19 | 9.72 | 116 | 134642 | 25127 | 64338847 |
PO2 increased | 28.11 | 9.72 | 24 | 134734 | 1468 | 64362506 |
Dyskinesia | 28.03 | 9.72 | 159 | 134599 | 39229 | 64324745 |
Peritonitis | 27.95 | 9.72 | 115 | 134643 | 24908 | 64339066 |
PCO2 increased | 27.76 | 9.72 | 25 | 134733 | 1642 | 64362332 |
Stevens-Johnson syndrome | 27.58 | 9.72 | 143 | 134615 | 34106 | 64329868 |
Hypoxia | 27.26 | 9.72 | 293 | 134465 | 87856 | 64276118 |
Blood magnesium decreased | 27.11 | 9.72 | 77 | 134681 | 13828 | 64350146 |
Therapy non-responder | 27.05 | 9.72 | 61 | 134697 | 65838 | 64298136 |
Feeling abnormal | 26.91 | 9.72 | 166 | 134592 | 133436 | 64230538 |
Abdominal pain upper | 26.76 | 9.72 | 514 | 134244 | 174516 | 64189458 |
Foetal death | 26.74 | 9.72 | 46 | 134712 | 5884 | 64358090 |
Cholecystitis | 26.65 | 9.72 | 96 | 134662 | 19540 | 64344434 |
Hypersensitivity | 26.61 | 9.72 | 272 | 134486 | 196180 | 64167794 |
Abortion spontaneous | 25.95 | 9.72 | 10 | 134748 | 25133 | 64338841 |
Cataract | 25.80 | 9.72 | 42 | 134716 | 51220 | 64312754 |
Disease progression | 25.52 | 9.72 | 427 | 134331 | 141253 | 64222721 |
Pancytopenia | 25.48 | 9.72 | 431 | 134327 | 142878 | 64221096 |
Blood alkaline phosphatase increased | 25.46 | 9.72 | 203 | 134555 | 56076 | 64307898 |
Intestinal perforation | 25.32 | 9.72 | 80 | 134678 | 15233 | 64348741 |
Stress | 24.87 | 9.72 | 56 | 134702 | 60478 | 64303496 |
Infusion site streaking | 24.84 | 9.72 | 14 | 134744 | 433 | 64363541 |
Non-small cell lung cancer | 24.81 | 9.72 | 40 | 134718 | 4850 | 64359124 |
Accidental exposure to product | 24.80 | 9.72 | 12 | 134746 | 26352 | 64337622 |
Gamma-glutamyltransferase increased | 24.76 | 9.72 | 180 | 134578 | 48330 | 64315644 |
Acute abdomen | 24.69 | 9.72 | 30 | 134728 | 2794 | 64361180 |
Irritable bowel syndrome | 24.62 | 9.72 | 25 | 134733 | 37344 | 64326630 |
Computerised tomogram thorax | 24.56 | 9.72 | 10 | 134748 | 146 | 64363828 |
Blood cholesterol increased | 24.29 | 9.72 | 42 | 134716 | 50024 | 64313950 |
Adverse drug reaction | 24.07 | 9.72 | 36 | 134722 | 45428 | 64318546 |
Secondary adrenocortical insufficiency | 23.98 | 9.72 | 27 | 134731 | 2318 | 64361656 |
Wheezing | 23.95 | 9.72 | 87 | 134671 | 80492 | 64283482 |
Joint injury | 23.89 | 9.72 | 9 | 134749 | 22938 | 64341036 |
Intentional product misuse | 23.56 | 9.72 | 75 | 134683 | 72220 | 64291754 |
Blood pressure systolic increased | 23.53 | 9.72 | 42 | 134716 | 49411 | 64314563 |
Cancer pain | 23.23 | 9.72 | 36 | 134722 | 4221 | 64359753 |
Drug clearance decreased | 23.19 | 9.72 | 28 | 134730 | 2591 | 64361383 |
Myocardial infarction | 23.11 | 9.72 | 228 | 134530 | 165593 | 64198381 |
Hyperprolactinaemia | 23.06 | 9.72 | 35 | 134723 | 4030 | 64359944 |
Blood bilirubin increased | 23.05 | 9.72 | 202 | 134556 | 57351 | 64306623 |
Platelet count decreased | 22.80 | 9.72 | 484 | 134274 | 167227 | 64196747 |
Injection site rash | 22.71 | 9.72 | 3 | 134755 | 15739 | 64348235 |
Carcinoid tumour of the stomach | 22.46 | 9.72 | 10 | 134748 | 184 | 64363790 |
Tachycardia | 22.43 | 9.72 | 438 | 134320 | 149141 | 64214833 |
Gelastic seizure | 22.41 | 9.72 | 5 | 134753 | 5 | 64363969 |
Folliculitis | 22.34 | 9.72 | 18 | 134740 | 30059 | 64333915 |
Encephalopathy | 22.31 | 9.72 | 204 | 134554 | 58615 | 64305359 |
Post concussion syndrome | 22.22 | 9.72 | 14 | 134744 | 533 | 64363441 |
Mobility decreased | 22.15 | 9.72 | 98 | 134660 | 85742 | 64278232 |
Hypoaesthesia | 22.11 | 9.72 | 185 | 134573 | 138923 | 64225051 |
Enterocolitis | 21.94 | 9.72 | 65 | 134693 | 11953 | 64352021 |
Respiratory dyskinesia | 21.76 | 9.72 | 7 | 134751 | 49 | 64363925 |
Infusion related reaction | 21.74 | 9.72 | 229 | 134529 | 164238 | 64199736 |
Inappropriate schedule of product administration | 21.67 | 9.72 | 109 | 134649 | 92177 | 64271797 |
Diabetes insipidus | 21.62 | 9.72 | 36 | 134722 | 4485 | 64359489 |
Cardiac failure congestive | 21.51 | 9.72 | 172 | 134586 | 130408 | 64233566 |
Haematopoietic stem cell mobilisation | 21.43 | 9.72 | 10 | 134748 | 206 | 64363768 |
Pancreatitis | 21.24 | 9.72 | 204 | 134554 | 59403 | 64304571 |
Porphyria acute | 21.00 | 9.72 | 15 | 134743 | 705 | 64363269 |
Thymus disorder | 20.88 | 9.72 | 10 | 134748 | 219 | 64363755 |
Deep vein thrombosis | 20.81 | 9.72 | 322 | 134436 | 104860 | 64259114 |
Hyponatraemic seizure | 20.80 | 9.72 | 13 | 134745 | 488 | 64363486 |
Confusional state | 20.63 | 9.72 | 702 | 134056 | 260442 | 64103532 |
Jaundice | 20.34 | 9.72 | 172 | 134586 | 48340 | 64315634 |
COVID-19 | 20.25 | 9.72 | 69 | 134689 | 65071 | 64298903 |
Influenza | 20.11 | 9.72 | 135 | 134623 | 106396 | 64257578 |
Injection site haemorrhage | 20.03 | 9.72 | 13 | 134745 | 24265 | 64339709 |
Blood bicarbonate decreased | 19.89 | 9.72 | 36 | 134722 | 4793 | 64359181 |
Ileus paralytic | 19.84 | 9.72 | 50 | 134708 | 8365 | 64355609 |
Onychalgia | 19.64 | 9.72 | 15 | 134743 | 782 | 64363192 |
Intentional self-injury | 19.63 | 9.72 | 19 | 134739 | 29025 | 64334949 |
Ill-defined disorder | 19.56 | 9.72 | 39 | 134719 | 44013 | 64319961 |
Hypoalbuminaemia | 19.56 | 9.72 | 81 | 134677 | 17593 | 64346381 |
Herpes zoster | 19.48 | 9.72 | 92 | 134666 | 79095 | 64284879 |
Sopor | 19.36 | 9.72 | 20 | 134738 | 29641 | 64334333 |
Mouth ulceration | 19.29 | 9.72 | 125 | 134633 | 32319 | 64331655 |
Excessive eye blinking | 19.24 | 9.72 | 18 | 134740 | 1242 | 64362732 |
Throat irritation | 19.24 | 9.72 | 24 | 134734 | 32687 | 64331287 |
Respiratory tract congestion | 19.23 | 9.72 | 5 | 134753 | 16160 | 64347814 |
Tumour lysis syndrome | 19.14 | 9.72 | 86 | 134672 | 19354 | 64344620 |
Hypocalcaemia | 19.10 | 9.72 | 151 | 134607 | 41602 | 64322372 |
Klebsiella bacteraemia | 19.08 | 9.72 | 24 | 134734 | 2316 | 64361658 |
Conjunctival irritation | 18.99 | 9.72 | 8 | 134750 | 128 | 64363846 |
Toxic encephalopathy | 18.80 | 9.72 | 54 | 134704 | 9761 | 64354213 |
Aortic rupture | 18.75 | 9.72 | 9 | 134749 | 198 | 64363776 |
Heart rate increased | 18.64 | 9.72 | 125 | 134633 | 98550 | 64265424 |
Lymphoid tissue hypoplasia | 18.54 | 9.72 | 12 | 134746 | 479 | 64363495 |
Enterochromaffin cell hyperplasia | 18.36 | 9.72 | 7 | 134751 | 85 | 64363889 |
Blood pressure diastolic decreased | 18.32 | 9.72 | 12 | 134746 | 22289 | 64341685 |
Urosepsis | 18.31 | 9.72 | 93 | 134665 | 22001 | 64341973 |
Skin candida | 18.09 | 9.72 | 20 | 134738 | 1683 | 64362291 |
Respiratory syncytial virus infection | 18.00 | 9.72 | 44 | 134714 | 7224 | 64356750 |
Therapy cessation | 17.92 | 9.72 | 25 | 134733 | 32464 | 64331510 |
Immune-mediated hepatitis | 17.91 | 9.72 | 24 | 134734 | 2465 | 64361509 |
Intestinal ischaemia | 17.89 | 9.72 | 59 | 134699 | 11490 | 64352484 |
Multiple sclerosis relapse | 17.77 | 9.72 | 37 | 134721 | 41098 | 64322876 |
Hepatitis fulminant | 17.74 | 9.72 | 40 | 134718 | 6234 | 64357740 |
Tumour pain | 17.66 | 9.72 | 21 | 134737 | 1912 | 64362062 |
Thymus hypoplasia | 17.64 | 9.72 | 12 | 134746 | 521 | 64363453 |
Hospitalisation | 17.56 | 9.72 | 89 | 134669 | 75118 | 64288856 |
Adverse event | 17.50 | 9.72 | 35 | 134723 | 39454 | 64324520 |
Neutropenic colitis | 17.42 | 9.72 | 33 | 134725 | 4548 | 64359426 |
Cardiac arrest | 17.33 | 9.72 | 433 | 134325 | 153631 | 64210343 |
Cystitis noninfective | 17.27 | 9.72 | 16 | 134742 | 1090 | 64362884 |
Malignant polyp | 17.27 | 9.72 | 8 | 134750 | 162 | 64363812 |
Alveolitis | 17.12 | 9.72 | 29 | 134729 | 3663 | 64360311 |
Diabetic gastroparesis | 16.94 | 9.72 | 9 | 134749 | 247 | 64363727 |
Hypergastrinaemia | 16.84 | 9.72 | 8 | 134750 | 172 | 64363802 |
Vascular access site occlusion | 16.78 | 9.72 | 6 | 134752 | 60 | 64363914 |
Left ventricular dysfunction | 16.69 | 9.72 | 75 | 134683 | 16879 | 64347095 |
Fluid retention | 16.64 | 9.72 | 66 | 134692 | 59540 | 64304434 |
Road traffic accident | 16.61 | 9.72 | 24 | 134734 | 30721 | 64333253 |
Hypochloraemia | 16.58 | 9.72 | 21 | 134737 | 2040 | 64361934 |
Cholangitis | 16.57 | 9.72 | 55 | 134703 | 10747 | 64353227 |
Polydipsia | 16.33 | 9.72 | 37 | 134721 | 5784 | 64358190 |
Pituitary tumour benign | 16.33 | 9.72 | 22 | 134736 | 2271 | 64361703 |
Emotional distress | 16.30 | 9.72 | 130 | 134628 | 35908 | 64328066 |
Device issue | 16.27 | 9.72 | 14 | 134744 | 22634 | 64341340 |
Product storage error | 16.07 | 9.72 | 4 | 134754 | 13314 | 64350660 |
Acute interstitial pneumonitis | 16.07 | 9.72 | 15 | 134743 | 1032 | 64362942 |
Failure to thrive | 15.98 | 9.72 | 53 | 134705 | 10351 | 64353623 |
Gaze palsy | 15.97 | 9.72 | 23 | 134735 | 2527 | 64361447 |
Hypophosphataemia | 15.93 | 9.72 | 67 | 134691 | 14653 | 64349321 |
Irritability | 15.92 | 9.72 | 33 | 134725 | 36713 | 64327261 |
Pseudomonal sepsis | 15.78 | 9.72 | 34 | 134724 | 5138 | 64358836 |
Pruritus | 15.74 | 9.72 | 515 | 134243 | 311885 | 64052089 |
Pancreatic carcinoma metastatic | 15.71 | 9.72 | 27 | 134731 | 3451 | 64360523 |
Torticollis | 15.67 | 9.72 | 21 | 134737 | 2156 | 64361818 |
Immune effector cell-associated neurotoxicity syndrome | 15.66 | 9.72 | 23 | 134735 | 2572 | 64361402 |
Sudden death | 15.56 | 9.72 | 83 | 134675 | 20013 | 64343961 |
Fibromyalgia | 15.55 | 9.72 | 32 | 134726 | 35699 | 64328275 |
Acanthosis | 15.52 | 9.72 | 10 | 134748 | 396 | 64363578 |
Enteritis | 15.51 | 9.72 | 58 | 134700 | 12019 | 64351955 |
Nasal congestion | 15.45 | 9.72 | 68 | 134690 | 59590 | 64304384 |
Obstruction gastric | 15.39 | 9.72 | 17 | 134741 | 1429 | 64362545 |
Product quality issue | 15.39 | 9.72 | 24 | 134734 | 29775 | 64334199 |
Incorrect dose administered | 15.29 | 9.72 | 70 | 134688 | 60695 | 64303279 |
Illness | 15.24 | 9.72 | 14 | 134744 | 21924 | 64342050 |
Disseminated aspergillosis | 15.22 | 9.72 | 12 | 134746 | 656 | 64363318 |
Colorectal cancer metastatic | 15.21 | 9.72 | 14 | 134744 | 946 | 64363028 |
Oxygen saturation abnormal | 15.19 | 9.72 | 27 | 134731 | 3544 | 64360430 |
Eructation | 15.18 | 9.72 | 48 | 134710 | 9143 | 64354831 |
Burning sensation | 15.17 | 9.72 | 53 | 134705 | 49611 | 64314363 |
Opisthotonus | 15.17 | 9.72 | 12 | 134746 | 659 | 64363315 |
Cachexia | 15.10 | 9.72 | 48 | 134710 | 9169 | 64354805 |
Embolism | 15.09 | 9.72 | 58 | 134700 | 12177 | 64351797 |
Memory impairment | 14.98 | 9.72 | 111 | 134647 | 85571 | 64278403 |
Non-cardiac chest pain | 14.95 | 9.72 | 46 | 134712 | 8634 | 64355340 |
Urinary retention | 14.95 | 9.72 | 163 | 134595 | 49038 | 64314936 |
Vitamin B12 decreased | 14.87 | 9.72 | 23 | 134735 | 2692 | 64361282 |
Therapy interrupted | 14.87 | 9.72 | 12 | 134746 | 20024 | 64343950 |
Spleen congestion | 14.75 | 9.72 | 10 | 134748 | 432 | 64363542 |
Tooth disorder | 14.74 | 9.72 | 15 | 134743 | 22387 | 64341587 |
Electrocardiogram T wave inversion | 14.74 | 9.72 | 32 | 134726 | 4862 | 64359112 |
Metastatic malignant melanoma | 14.59 | 9.72 | 22 | 134736 | 2519 | 64361455 |
Mesothelioma | 14.52 | 9.72 | 9 | 134749 | 333 | 64363641 |
Tumour perforation | 14.49 | 9.72 | 9 | 134749 | 334 | 64363640 |
Bacteraemia | 14.39 | 9.72 | 101 | 134657 | 26810 | 64337164 |
Biliary dyskinesia | 14.28 | 9.72 | 21 | 134737 | 2351 | 64361623 |
Clonus | 14.26 | 9.72 | 36 | 134722 | 6031 | 64357943 |
Immunodeficiency | 14.19 | 9.72 | 8 | 134750 | 16116 | 64347858 |
Balance disorder | 14.07 | 9.72 | 110 | 134648 | 83816 | 64280158 |
Pulmonary sepsis | 14.06 | 9.72 | 24 | 134734 | 3051 | 64360923 |
Laryngeal cancer metastatic | 13.98 | 9.72 | 5 | 134753 | 50 | 64363924 |
Bronchitis | 13.73 | 9.72 | 153 | 134605 | 108590 | 64255384 |
Dyspepsia | 13.71 | 9.72 | 240 | 134518 | 80072 | 64283902 |
Hyperthermia malignant | 13.71 | 9.72 | 21 | 134737 | 2438 | 64361536 |
Myalgia | 13.67 | 9.72 | 241 | 134517 | 158376 | 64205598 |
Palmar-plantar erythrodysaesthesia syndrome | 13.61 | 9.72 | 105 | 134653 | 28714 | 64335260 |
Adrenal insufficiency | 13.59 | 9.72 | 87 | 134671 | 22400 | 64341574 |
Rash | 13.55 | 9.72 | 802 | 133956 | 457747 | 63906227 |
Extravasation blood | 13.45 | 9.72 | 9 | 134749 | 380 | 64363594 |
Tenosynovitis | 13.44 | 9.72 | 4 | 134754 | 11829 | 64352145 |
Blood pressure diastolic increased | 13.43 | 9.72 | 3 | 134755 | 10749 | 64353225 |
Hyperbilirubinaemia | 13.41 | 9.72 | 83 | 134675 | 21122 | 64342852 |
Insomnia | 13.34 | 9.72 | 313 | 134445 | 197523 | 64166451 |
Chills | 13.20 | 9.72 | 378 | 134380 | 136886 | 64227088 |
Tracheal injury | 13.17 | 9.72 | 5 | 134753 | 60 | 64363914 |
Gallbladder injury | 13.10 | 9.72 | 14 | 134744 | 1134 | 64362840 |
Foetal malpresentation | 13.09 | 9.72 | 5 | 134753 | 61 | 64363913 |
Mania | 13.06 | 9.72 | 9 | 134749 | 16277 | 64347697 |
Musculoskeletal disorder | 12.95 | 9.72 | 11 | 134747 | 17895 | 64346079 |
Mucosal erosion | 12.93 | 9.72 | 18 | 134740 | 1916 | 64362058 |
No adverse event | 12.93 | 9.72 | 25 | 134733 | 28536 | 64335438 |
Joint effusion | 12.88 | 9.72 | 6 | 134752 | 13467 | 64350507 |
Angioedema | 12.87 | 9.72 | 76 | 134682 | 61745 | 64302229 |
Escherichia test positive | 12.85 | 9.72 | 22 | 134736 | 2803 | 64361171 |
Ocular hyperaemia | 12.81 | 9.72 | 17 | 134741 | 22547 | 64341427 |
Immune reconstitution inflammatory syndrome | 12.80 | 9.72 | 5 | 134753 | 12465 | 64351509 |
Faecaloma | 12.73 | 9.72 | 47 | 134711 | 9681 | 64354293 |
Delusional disorder, persecutory type | 12.71 | 9.72 | 9 | 134749 | 417 | 64363557 |
Neutropenic infection | 12.71 | 9.72 | 18 | 134740 | 1947 | 64362027 |
Oesophageal ulcer | 12.71 | 9.72 | 35 | 134723 | 6175 | 64357799 |
Neutrophilic dermatosis | 12.71 | 9.72 | 10 | 134748 | 545 | 64363429 |
Radiation pneumonitis | 12.69 | 9.72 | 24 | 134734 | 3304 | 64360670 |
Seizure | 12.50 | 9.72 | 446 | 134312 | 166446 | 64197528 |
Vascular encephalopathy | 12.44 | 9.72 | 10 | 134748 | 562 | 64363412 |
Death | 12.42 | 9.72 | 855 | 133903 | 481850 | 63882124 |
Heart rate irregular | 12.40 | 9.72 | 24 | 134734 | 27389 | 64336585 |
Bursitis | 12.39 | 9.72 | 16 | 134742 | 21469 | 64342505 |
Flail chest | 12.34 | 9.72 | 5 | 134753 | 72 | 64363902 |
COVID-19 treatment | 12.32 | 9.72 | 9 | 134749 | 438 | 64363536 |
Seborrhoeic dermatitis | 12.22 | 9.72 | 17 | 134741 | 1809 | 64362165 |
Multiple drug therapy | 12.21 | 9.72 | 19 | 134739 | 2235 | 64361739 |
Myoclonus | 12.13 | 9.72 | 92 | 134666 | 25026 | 64338948 |
Leukoencephalopathy | 12.08 | 9.72 | 37 | 134721 | 6930 | 64357044 |
Nail infection | 12.07 | 9.72 | 17 | 134741 | 1830 | 64362144 |
Paradoxical drug reaction | 12.04 | 9.72 | 34 | 134724 | 6086 | 64357888 |
Aminoaciduria | 12.04 | 9.72 | 7 | 134751 | 230 | 64363744 |
Overdose | 12.04 | 9.72 | 248 | 134510 | 159318 | 64204656 |
Tooth fracture | 11.94 | 9.72 | 3 | 134755 | 9924 | 64354050 |
Sleep apnoea syndrome | 11.93 | 9.72 | 28 | 134730 | 29804 | 64334170 |
Glaucoma | 11.88 | 9.72 | 10 | 134748 | 16338 | 64347636 |
Intestinal obstruction | 11.86 | 9.72 | 122 | 134636 | 36164 | 64327810 |
Cytomegalovirus infection | 11.83 | 9.72 | 39 | 134719 | 37160 | 64326814 |
Chemotherapeutic drug level increased | 11.83 | 9.72 | 8 | 134750 | 344 | 64363630 |
Joint stiffness | 11.79 | 9.72 | 29 | 134729 | 30375 | 64333599 |
Hypoglycaemic seizure | 11.78 | 9.72 | 11 | 134747 | 757 | 64363217 |
Suicidal ideation | 11.73 | 9.72 | 86 | 134672 | 66456 | 64297518 |
Generalised oedema | 11.59 | 9.72 | 79 | 134679 | 20774 | 64343200 |
Prostate cancer metastatic | 11.59 | 9.72 | 23 | 134735 | 3281 | 64360693 |
Acne | 11.53 | 9.72 | 19 | 134739 | 23062 | 64340912 |
Urinary tract infection | 11.52 | 9.72 | 593 | 134165 | 231003 | 64132971 |
Erectile dysfunction | 11.50 | 9.72 | 6 | 134752 | 12621 | 64351353 |
Body temperature decreased | 11.47 | 9.72 | 23 | 134735 | 25905 | 64338069 |
Pericardial effusion | 11.45 | 9.72 | 129 | 134629 | 39125 | 64324849 |
Impaired work ability | 11.44 | 9.72 | 9 | 134749 | 15210 | 64348764 |
Injection site warmth | 11.39 | 9.72 | 7 | 134751 | 13455 | 64350519 |
Pathogen resistance | 11.36 | 9.72 | 6 | 134752 | 12537 | 64351437 |
Blood pH decreased | 11.28 | 9.72 | 27 | 134731 | 4375 | 64359599 |
Post transplant lymphoproliferative disorder | 11.26 | 9.72 | 3 | 134755 | 9541 | 64354433 |
Delirium | 11.18 | 9.72 | 205 | 134553 | 68989 | 64294985 |
Febrile infection | 11.16 | 9.72 | 21 | 134737 | 2880 | 64361094 |
Muscle spasticity | 11.15 | 9.72 | 11 | 134747 | 16658 | 64347316 |
Blood aluminium increased | 11.14 | 9.72 | 3 | 134755 | 10 | 64363964 |
Abdominal tenderness | 11.12 | 9.72 | 44 | 134714 | 9361 | 64354613 |
Carpal tunnel syndrome | 11.11 | 9.72 | 10 | 134748 | 15818 | 64348156 |
Vascular pain | 11.10 | 9.72 | 11 | 134747 | 815 | 64363159 |
Intercepted product administration error | 11.06 | 9.72 | 6 | 134752 | 172 | 64363802 |
Blood sodium decreased | 11.05 | 9.72 | 102 | 134656 | 29380 | 64334594 |
Poor quality sleep | 11.04 | 9.72 | 14 | 134744 | 18937 | 64345037 |
Foot deformity | 10.92 | 9.72 | 11 | 134747 | 16493 | 64347481 |
Cardiac disorder | 10.90 | 9.72 | 70 | 134688 | 55746 | 64308228 |
Eye pain | 10.88 | 9.72 | 32 | 134726 | 31593 | 64332381 |
Cholelithiasis | 10.86 | 9.72 | 144 | 134614 | 45362 | 64318612 |
Restless arm syndrome | 10.84 | 9.72 | 4 | 134754 | 44 | 64363930 |
Performance status decreased | 10.75 | 9.72 | 30 | 134728 | 5334 | 64358640 |
Increased tendency to bruise | 10.75 | 9.72 | 3 | 134755 | 9252 | 64354722 |
Naevus haemorrhage | 10.72 | 9.72 | 5 | 134753 | 103 | 64363871 |
Stress cardiomyopathy | 10.70 | 9.72 | 43 | 134715 | 9214 | 64354760 |
Catheter site bruise | 10.65 | 9.72 | 7 | 134751 | 287 | 64363687 |
Abdominal compartment syndrome | 10.63 | 9.72 | 14 | 134744 | 1414 | 64362560 |
Plantar erythema | 10.63 | 9.72 | 7 | 134751 | 288 | 64363686 |
Abdominal sepsis | 10.60 | 9.72 | 16 | 134742 | 1834 | 64362140 |
Muscle twitching | 10.57 | 9.72 | 72 | 134686 | 18926 | 64345048 |
Hypoacusis | 10.57 | 9.72 | 24 | 134734 | 25843 | 64338131 |
Sinus congestion | 10.55 | 9.72 | 10 | 134748 | 15429 | 64348545 |
Systemic infection | 10.53 | 9.72 | 26 | 134732 | 4295 | 64359679 |
Underdose | 10.52 | 9.72 | 24 | 134734 | 25805 | 64338169 |
Transfusion | 10.50 | 9.72 | 69 | 134689 | 17925 | 64346049 |
Eastern Cooperative Oncology Group performance status worsened | 10.49 | 9.72 | 13 | 134745 | 1235 | 64362739 |
Retching | 10.47 | 9.72 | 61 | 134697 | 15195 | 64348779 |
Respiratory failure | 10.46 | 9.72 | 424 | 134334 | 160759 | 64203215 |
Sinus tachycardia | 10.42 | 9.72 | 108 | 134650 | 32080 | 64331894 |
Alopecia | 10.39 | 9.72 | 265 | 134493 | 165425 | 64198549 |
Sinus disorder | 10.37 | 9.72 | 12 | 134746 | 16896 | 64347078 |
Numb chin syndrome | 10.35 | 9.72 | 3 | 134755 | 14 | 64363960 |
Thrombosis | 10.31 | 9.72 | 96 | 134662 | 70546 | 64293428 |
Limb injury | 10.27 | 9.72 | 21 | 134737 | 23484 | 64340490 |
Porphyria | 10.27 | 9.72 | 6 | 134752 | 199 | 64363775 |
Back disorder | 10.27 | 9.72 | 4 | 134754 | 9986 | 64353988 |
Visual impairment | 10.25 | 9.72 | 102 | 134656 | 73975 | 64289999 |
Pancreatitis haemorrhagic | 10.19 | 9.72 | 9 | 134749 | 576 | 64363398 |
Faecalith | 10.18 | 9.72 | 3 | 134755 | 15 | 64363959 |
Disturbance in social behaviour | 10.13 | 9.72 | 24 | 134734 | 3863 | 64360111 |
Surgery | 10.11 | 9.72 | 28 | 134730 | 28185 | 64335789 |
Progressive multifocal leukoencephalopathy | 10.08 | 9.72 | 14 | 134744 | 18218 | 64345756 |
Mood swings | 10.08 | 9.72 | 13 | 134745 | 17455 | 64346519 |
Grip strength decreased | 10.06 | 9.72 | 6 | 134752 | 11718 | 64352256 |
Alanine aminotransferase increased | 10.03 | 9.72 | 370 | 134388 | 138661 | 64225313 |
Morning sickness | 10.02 | 9.72 | 8 | 134750 | 445 | 64363529 |
Transplant rejection | 9.99 | 9.72 | 13 | 134745 | 17388 | 64346586 |
Foot fracture | 9.98 | 9.72 | 14 | 134744 | 18143 | 64345831 |
Dyschezia | 9.97 | 9.72 | 18 | 134740 | 2392 | 64361582 |
Immune-mediated enterocolitis | 9.94 | 9.72 | 19 | 134739 | 2637 | 64361337 |
Spinal cord injury thoracic | 9.91 | 9.72 | 5 | 134753 | 123 | 64363851 |
Circulatory collapse | 9.90 | 9.72 | 111 | 134647 | 33621 | 64330353 |
Vocal cord inflammation | 9.90 | 9.72 | 6 | 134752 | 213 | 64363761 |
Generalised tonic-clonic seizure | 9.88 | 9.72 | 127 | 134631 | 39730 | 64324244 |
Device breakage | 9.87 | 9.72 | 3 | 134755 | 8752 | 64355222 |
Electrocardiogram change | 9.82 | 9.72 | 12 | 134746 | 1124 | 64362850 |
Injection site mass | 9.81 | 9.72 | 13 | 134745 | 17257 | 64346717 |
Lung infiltration | 9.80 | 9.72 | 76 | 134682 | 20813 | 64343161 |
Hyperpyrexia | 9.79 | 9.72 | 28 | 134730 | 5049 | 64358925 |
Gastroenteritis clostridial | 9.75 | 9.72 | 10 | 134748 | 772 | 64363202 |
None
Source | Code | Description |
---|---|---|
ATC | A03FA01 | ALIMENTARY TRACT AND METABOLISM DRUGS FOR FUNCTIONAL GASTROINTESTINAL DISORDERS PROPULSIVES Propulsives |
MeSH PA | D000932 | Antiemetics |
MeSH PA | D002491 | Central Nervous System Agents |
MeSH PA | D015259 | Dopamine Agents |
MeSH PA | D018492 | Dopamine Antagonists |
MeSH PA | D065127 | Dopamine D2 Receptor Antagonists |
MeSH PA | D005765 | Gastrointestinal Agents |
MeSH PA | D018377 | Neurotransmitter Agents |
MeSH PA | D018373 | Peripheral Nervous System Agents |
FDA MoA | N0000175799 | Dopamine D2 Antagonists |
FDA EPC | N0000175800 | Dopamine-2 Receptor Antagonist |
CHEBI has role | CHEBI:35703 | Xenobiotic |
CHEBI has role | CHEBI:48561 | dopaminergic antagonists |
CHEBI has role | CHEBI:50919 | antiemetico |
CHEBI has role | CHEBI:55324 | gastrointestinal drugs |
CHEBI has role | CHEBI:78298 | environmental contaminants |
Disease | Relation | SNOMED_ID | DOID |
---|---|---|---|
Diabetic gastroparesis | indication | 34140002 | |
Intubation of gastrointestinal tract | indication | 235419001 | |
Gastroesophageal reflux disease | indication | 235595009 | DOID:8534 |
Chemotherapy-induced nausea and vomiting | indication | 236084000 | |
Prevention of Post-Operative Nausea and Vomiting | indication | ||
Gastrointestinal Radiography Adjunct | indication | ||
Suicidal thoughts | contraindication | 6471006 | |
Neuroleptic malignant syndrome | contraindication | 15244003 | DOID:14464 |
Cirrhosis of liver | contraindication | 19943007 | DOID:5082 |
Parkinsonism | contraindication | 32798002 | |
Depressive disorder | contraindication | 35489007 | |
Hypertensive disorder | contraindication | 38341003 | DOID:10763 |
Body fluid retention | contraindication | 43498006 | |
Mechanical ileus | contraindication | 46420000 | |
Chronic heart failure | contraindication | 48447003 | |
Gastrointestinal perforation | contraindication | 51875005 | |
Gastrointestinal hemorrhage | contraindication | 74474003 | |
Tardive dyskinesia | contraindication | 102449007 | |
Deficiency of cytochrome-b>5< reductase | contraindication | 124184009 | |
Seizure disorder | contraindication | 128613002 | |
Impaired renal function disorder | contraindication | 197663003 | |
Anastomosis of intestine | contraindication | 235407009 | |
Pheochromocytoma | contraindication | 302835009 | |
Porphyria | contraindication | 418470004 | |
Acquired torsion dystonia | contraindication | 433493000 |
None
None
Dissociation level | Dissociation constant | Type (acidic/basic) |
---|---|---|
pKa1 | 13.17 | acidic |
pKa2 | 8.94 | Basic |
pKa3 | 1.08 | Basic |
Formulation strength | Trade name | Applicant | Application number | Approval date | Type | Dose form | Route | Patent number | Patent expiration date | Patent use |
---|---|---|---|---|---|---|---|---|---|---|
EQ 15MG BASE/SPRAY | GIMOTI | EVOKE PHARMA INC | N209388 | June 19, 2020 | RX | SPRAY, METERED | NASAL | 11020361 | Dec. 22, 2029 | NASAL ADMINISTRATION OF METOCLOPRAMIDE FOR TREATMENT OF DIABETIC GASTROPARESIS |
EQ 15MG BASE/SPRAY | GIMOTI | EVOKE PHARMA INC | N209388 | June 19, 2020 | RX | SPRAY, METERED | NASAL | 8334281 | May 16, 2030 | NASAL ADMINISTRATION OF METOCLOPRAMIDE FOR TREATMENT OF DIABETIC GASTROPARESIS |
Formulation strength | Trade name | Applicant | Application number | Approval date | Type | Dose form | Route | Exclusivity date | Description |
---|---|---|---|---|---|---|---|---|---|
EQ 15MG BASE/SPRAY | GIMOTI | EVOKE PHARMA INC | N209388 | June 19, 2020 | RX | SPRAY, METERED | NASAL | June 19, 2023 | NEW PRODUCT |
Target | Class | Pharos | UniProt | Action | Type | Activity value (-log[M]) | Mechanism action | Bioact source | MoA source |
---|---|---|---|---|---|---|---|---|---|
D(2) dopamine receptor | GPCR | ANTAGONIST | Ki | 7.19 | WOMBAT-PK | CHEMBL | |||
5-hydroxytryptamine receptor 3A | Ion channel | ANTAGONIST | Ki | 6.70 | WOMBAT-PK | CHEMBL | |||
5-hydroxytryptamine receptor 4 | GPCR | AGONIST | EC50 | 6 | WOMBAT-PK | CHEMBL | |||
5-hydroxytryptamine receptor 2A | GPCR | Ki | 5.98 | DRUG MATRIX | |||||
5-hydroxytryptamine receptor 2B | GPCR | Ki | 6.40 | DRUG MATRIX | |||||
5-hydroxytryptamine receptor 2C | GPCR | Ki | 5.90 | DRUG MATRIX | |||||
D(3) dopamine receptor | GPCR | Ki | 7.66 | WOMBAT-PK | |||||
Aldehyde oxidase | Enzyme | IC50 | 4.51 | WOMBAT-PK | |||||
Cytochrome P450 2D6 | Enzyme | IC50 | 6.10 | DRUG MATRIX | |||||
Myeloperoxidase | Enzyme | IC50 | 6.46 | CHEMBL | |||||
Solute carrier family 22 member 1 | Transporter | IC50 | 4.02 | CHEMBL | |||||
Serotonin 3 (5-HT3) receptor | Ion channel | Kd | 7.30 | CHEMBL | |||||
Muscarinic acetylcholine receptor M1 | GPCR | WOMBAT-PK | |||||||
Alpha-2A adrenergic receptor | GPCR | Ki | 5.99 | DRUG MATRIX | |||||
D(2) dopamine receptor | GPCR | Ki | 6.98 | CHEMBL | |||||
D(2) dopamine receptor | GPCR | Ki | 7.10 | CHEMBL | |||||
D(2) dopamine receptor | GPCR | ANTAGONIST | Ki | 7.54 | IUPHAR | ||||
5-hydroxytryptamine receptor 4 | GPCR | Ki | 6.05 | CHEMBL | |||||
D(3) dopamine receptor | GPCR | IC50 | 7.21 | CHEMBL | |||||
Serotonin 3 (5-HT3) receptor | Ion channel | Ki | 6.68 | CHEMBL | |||||
Serotonin 1 (5-HT1) receptor | GPCR | IC50 | 5.11 | CHEMBL | |||||
Adrenergic receptor alpha-2 | GPCR | IC50 | 5.11 | CHEMBL | |||||
Adrenergic receptor alpha-1 | GPCR | IC50 | 4.48 | CHEMBL | |||||
Serotonin 2 (5-HT2) receptor | GPCR | IC50 | 4.88 | CHEMBL | |||||
Serotonin 3 receptor (5HT3) | Ion channel | Ki | 6.70 | CHEMBL | |||||
5-hydroxytryptamine receptor 4 | GPCR | AGONIST | Ki | 6 | IUPHAR | ||||
5-hydroxytryptamine receptor 4 | GPCR | Ki | 6.26 | CHEMBL |
ID | Source |
---|---|
4019835 | VUID |
N0000147923 | NUI |
D00726 | KEGG_DRUG |
54143-57-6 | SECONDARY_CAS_RN |
4017905 | VANDF |
4019835 | VANDF |
C0025853 | UMLSCUI |
CHEBI:107736 | CHEBI |
CHEMBL86 | ChEMBL_ID |
DB01233 | DRUGBANK_ID |
CHEMBL1200940 | ChEMBL_ID |
CHEMBL1256771 | ChEMBL_ID |
D008787 | MESH_DESCRIPTOR_UI |
4168 | PUBCHEM_CID |
241 | IUPHAR_LIGAND_ID |
1740 | INN_ID |
L4YEB44I46 | UNII |
267036 | RXNORM |
1062 | MMSL |
34842 | MMSL |
5099 | MMSL |
d00298 | MMSL |
001877 | NDDF |
004778 | NDDF |
31147000 | SNOMEDCT_US |
372776000 | SNOMEDCT_US |
56549003 | SNOMEDCT_US |
Product | Category | Ingredients | NDC | Form | Quantity | Route | Marketing | Label |
---|---|---|---|---|---|---|---|---|
Metoclopramide | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0093-2203 | TABLET | 10 mg | ORAL | ANDA | 26 sections |
Metoclopramide | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0093-2204 | TABLET | 5 mg | ORAL | ANDA | 26 sections |
Metoclopramide | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0121-0576 | SOLUTION | 5 mg | ORAL | ANDA | 28 sections |
Metoclopramide | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0121-1576 | SOLUTION | 5 mg | ORAL | ANDA | 28 sections |
Metoclopramide | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0404-9910 | INJECTION, SOLUTION | 5 mg | INTRAVENOUS | ANDA | 13 sections |
Metoclopramide | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0409-3414 | INJECTION, SOLUTION | 5 mg | INTRAMUSCULAR | ANDA | 15 sections |
Metoclopramide | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0440-1771 | TABLET | 10 mg | ORAL | ANDA | 22 sections |
Metoclopramide | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0615-7698 | TABLET | 5 mg | ORAL | ANDA | 27 sections |
Metoclopramide | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0615-7698 | TABLET | 5 mg | ORAL | ANDA | 27 sections |
Metoclopramide | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0615-8285 | TABLET | 10 mg | ORAL | ANDA | 27 sections |
Metoclopramide | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0615-8285 | TABLET | 10 mg | ORAL | ANDA | 27 sections |
Metoclopramide | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0703-4502 | INJECTION, SOLUTION | 5 mg | INTRAMUSCULAR | ANDA | 23 sections |
Metoclopramide | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0703-4502 | INJECTION, SOLUTION | 5 mg | INTRAMUSCULAR | ANDA | 23 sections |
Metoclopramide | HUMAN PRESCRIPTION DRUG LABEL | 1 | 12634-112 | TABLET | 10 mg | ORAL | ANDA | 22 sections |
METOCLOPRAMIDE | HUMAN PRESCRIPTION DRUG LABEL | 1 | 16590-150 | TABLET | 5 mg | ORAL | ANDA | 25 sections |
METOCLOPRAMIDE | HUMAN PRESCRIPTION DRUG LABEL | 1 | 16590-151 | TABLET | 10 mg | ORAL | ANDA | 25 sections |
REGLAN | HUMAN PRESCRIPTION DRUG LABEL | 1 | 16590-906 | TABLET | 10 mg | ORAL | NDA | 24 sections |
Metoclopramide | HUMAN PRESCRIPTION DRUG LABEL | 1 | 17856-0576 | SOLUTION | 5 mg | ORAL | ANDA | 24 sections |
Metoclopramide | HUMAN PRESCRIPTION DRUG LABEL | 1 | 21695-346 | TABLET | 10 mg | ORAL | ANDA | 19 sections |
Metoclopramide | HUMAN PRESCRIPTION DRUG LABEL | 1 | 21695-485 | TABLET | 5 mg | ORAL | ANDA | 19 sections |
Metoclopramide | HUMAN PRESCRIPTION DRUG LABEL | 1 | 23155-240 | INJECTION | 5 mg | INTRAMUSCULAR | ANDA | 21 sections |
Metoclopramide | HUMAN PRESCRIPTION DRUG LABEL | 1 | 33261-166 | TABLET | 10 mg | ORAL | ANDA | 22 sections |
METOCLOPRAMIDE hydrochloride | HUMAN PRESCRIPTION DRUG LABEL | 1 | 40032-580 | TABLET, ORALLY DISINTEGRATING | 10 mg | ORAL | ANDA | 25 sections |
METOCLOPRAMIDE hydrochloride | HUMAN PRESCRIPTION DRUG LABEL | 1 | 40032-581 | TABLET, ORALLY DISINTEGRATING | 5 mg | ORAL | ANDA | 25 sections |
Metoclopramide Hydrochloride | HUMAN PRESCRIPTION DRUG LABEL | 1 | 42254-196 | TABLET | 5 mg | ORAL | ANDA | 22 sections |
Metoclopramide Hydrochloride | HUMAN PRESCRIPTION DRUG LABEL | 1 | 42254-266 | TABLET | 10 mg | ORAL | ANDA | 22 sections |
Metoclopramide | HUMAN PRESCRIPTION DRUG LABEL | 1 | 42291-595 | TABLET | 5 mg | ORAL | ANDA | 27 sections |
Metoclopramide | HUMAN PRESCRIPTION DRUG LABEL | 1 | 42291-596 | TABLET | 10 mg | ORAL | ANDA | 27 sections |
Metoclopramide | HUMAN PRESCRIPTION DRUG LABEL | 1 | 43353-274 | TABLET | 10 mg | ORAL | ANDA | 22 sections |
Metoclopramide Hydrochloride | HUMAN PRESCRIPTION DRUG LABEL | 1 | 43353-808 | TABLET | 10 mg | ORAL | ANDA | 22 sections |