itopride 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
sulpiride derivatives 1512 122898-67-3

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • itopride hydrochloride
  • ganaton
  • itopride
  • itropride
  • itopride HCl
  • Molecular weight: 358.44
  • Formula: C20H26N2O4
  • CLOGP: 2.64
  • LIPINSKI: 0
  • HAC: 6
  • HDO: 1
  • TPSA: 60.03
  • ALOGS: -4.14
  • ROTB: 9

Drug dosage:

DoseUnitRoute
0.15 g O

ADMET properties:

None

Approvals:

None

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Trimethylaminuria 130.08 52.05 16 628 122 50604358
Pseudomembranous colitis 88.20 52.05 17 627 2768 50601712
Megacolon 76.74 52.05 14 630 1692 50602788
Peritonitis 72.90 52.05 20 624 15466 50589014
Dysbiosis 68.06 52.05 11 633 649 50603831
Intestinal perforation 65.77 52.05 17 627 10462 50594018

FDA Adverse Event Reporting System (Male)

None

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Trimethylaminuria 134.85 36.40 17 891 144 64497680
Pseudomembranous colitis 82.35 36.40 18 890 4898 64492926
Megacolon 72.85 36.40 15 893 3067 64494757
Dysbiosis 70.40 36.40 12 896 883 64496941
Peritonitis 65.43 36.40 21 887 25002 64472822
Intestinal perforation 62.04 36.40 18 890 15295 64482529
Clostridium difficile infection 39.81 36.40 16 892 36147 64461677
Inhibitory drug interaction 37.64 36.40 9 899 3618 64494206

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
ATC A03FA07 ALIMENTARY TRACT AND METABOLISM
DRUGS FOR FUNCTIONAL GASTROINTESTINAL DISORDERS
PROPULSIVES
Propulsives

Drug Use | Suggest Off label Use Form| |View source of the data|

DiseaseRelationSNOMED_IDDOID
Chronic gastritis indication 8493009




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 8.61 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

None

External reference:

IDSource
D02729 KEGG_DRUG
122892-31-3 SECONDARY_CAS_RN
C0531483 UMLSCUI
CHEBI:94809 CHEBI
CHEMBL2107457 ChEMBL_ID
DB04924 DRUGBANK_ID
C102254 MESH_SUPPLEMENTAL_RECORD_UI
3792 PUBCHEM_CID
6879 INN_ID
81BMQ80QRL UNII
017624 NDDF
017625 NDDF
20691000122100 SNOMEDCT_US

Pharmaceutical products:

None