itopride Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
sulpiride derivatives 1512 122898-67-3

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • itopride hydrochloride
  • ganaton
  • itopride
  • itropride
  • itopride HCl
  • Molecular weight: 358.44
  • Formula: C20H26N2O4
  • CLOGP: 2.73
  • LIPINSKI: 0
  • HAC: 6
  • HDO: 1
  • TPSA: 60.03
  • ALOGS: -4.14
  • ROTB: 9

Drug dosage:

None

ADMET properties:

None

Approvals:

None

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Trimethylaminuria 110.04 33.53 15 986 154 46684907
Pseudomembranous colitis 71.45 33.53 16 985 3179 46681882
Peritonitis 64.54 33.53 22 979 20692 46664369
Megacolon 57.73 33.53 12 989 1679 46683382
Dysbiosis 50.92 33.53 9 992 533 46684528
Intestinal perforation 47.84 33.53 15 986 10836 46674225
Psychomotor retardation 34.91 33.53 9 992 3224 46681837

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event

Pharmacologic Action:

SourceCodeDescription
ATC A03FA07 ALIMENTARY TRACT AND METABOLISM
DRUGS FOR FUNCTIONAL GASTROINTESTINAL DISORDERS
PROPULSIVES
Propulsives

Drug Use (View source of the data)

DiseaseRelationSNOMED_IDDOID
Chronic gastritis indication 8493009

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 8.61 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

None

External reference:

IDSource
D02729 KEGG_DRUG
122892-31-3 SECONDARY_CAS_RN
C0531483 UMLSCUI
CHEBI:94809 CHEBI
CHEMBL2107457 ChEMBL_ID
DB04924 DRUGBANK_ID
C102254 MESH_SUPPLEMENTAL_RECORD_UI
6879 INN_ID
81BMQ80QRL UNII
129791 PUBCHEM_CID
017624 NDDF
017625 NDDF
20691000122100 SNOMEDCT_US

Pharmaceutical products:

None