domperidone 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
antipsychotics, risperidone derivatives 945 57808-66-9

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • domperidone betadex
  • domperidone betacyclodextrin
  • domperidone
  • motilium
  • peridon
  • domperidone maleate
A specific blocker of dopamine receptors. It speeds gastrointestinal peristalsis, causes prolactin release, and is used as antiemetic and tool in the study of dopaminergic mechanisms.
  • Molecular weight: 425.92
  • Formula: C22H24ClN5O2
  • CLOGP: 3.87
  • LIPINSKI: 0
  • HAC: 7
  • HDO: 2
  • TPSA: 67.92
  • ALOGS: -3.66
  • ROTB: 5

Drug dosage:

DoseUnitRoute
30 mg O
30 mg P
0.12 g R

ADMET properties:

PropertyValueReference
BDDCS (Biopharmaceutical Drug Disposition Classification System) 2 Benet LZ, Broccatelli F, Oprea TI
S (Water solubility) 0.01 mg/mL Benet LZ, Broccatelli F, Oprea TI
EoM (Fraction excreted unchanged in urine) 0 % Benet LZ, Broccatelli F, Oprea TI
MRTD (Maximum Recommended Therapeutic Daily Dose) 0.34 µM/kg/day Contrera JF, Matthews EJ, Kruhlak NL, Benz RD
BA (Bioavailability) 15 % Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H
Vd (Volume of distribution) 3.40 L/kg Lombardo F, Berellini G, Obach RS
CL (Clearance) 9.50 mL/min/kg Lombardo F, Berellini G, Obach RS
fu (Fraction unbound in plasma) 0.08 % Lombardo F, Berellini G, Obach RS
t_half (Half-life) 7.50 hours Lombardo F, Berellini G, Obach RS

Approvals:

DateAgencyCompanyOrphan
Jan. 1, 1982 YEAR INTRODUCED

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Premature labour 174.73 11.75 106 41051 12398 63435467
Derealisation 134.07 11.75 44 41113 1164 63446701
Gastric pH decreased 131.30 11.75 39 41118 735 63447130
Blepharospasm 130.55 11.75 68 41089 5928 63441937
Depersonalisation/derealisation disorder 120.82 11.75 42 41115 1330 63446535
Sensory loss 99.25 11.75 69 41088 10169 63437696
H1N1 influenza 96.82 11.75 38 41119 1701 63446164
Pulmonary malformation 96.69 11.75 25 41132 274 63447591
Cogwheel rigidity 92.23 11.75 38 41119 1932 63445933
Pemphigus 89.65 11.75 8 41149 183718 63264147
Hypoaesthesia oral 88.63 11.75 71 41086 12962 63434903
Feeling of despair 85.94 11.75 38 41119 2301 63445564
Vomiting 85.89 11.75 638 40519 558979 62888886
Systemic lupus erythematosus 85.43 11.75 16 41141 208902 63238963
Dissociation 83.95 11.75 40 41117 2879 63444986
Taste disorder 81.56 11.75 69 41088 13593 63434272
Epilepsy 78.06 11.75 92 41065 26973 63420892
Hypersensitivity 77.40 11.75 47 41110 292638 63155227
Hyperprolactinaemia 75.78 11.75 41 41116 3859 63444006
Arterial occlusive disease 74.33 11.75 47 41110 5911 63441954
Gangrene 73.16 11.75 47 41110 6076 63441789
Completed suicide 71.99 11.75 6 41151 145667 63302198
Respiratory tract malformation 71.57 11.75 18 41139 175 63447690
Drooling 70.55 11.75 39 41118 3829 63444036
Drug ineffective 69.73 11.75 396 40761 1044369 62403496
Total lung capacity decreased 69.22 11.75 32 41125 2151 63445714
Nightmare 68.65 11.75 73 41084 19121 63428744
Arthropathy 65.93 11.75 35 41122 234757 63213108
Therapeutic product ineffective 65.79 11.75 29 41128 1743 63446122
Lung cyst 65.68 11.75 19 41138 325 63447540
Muscle disorder 64.00 11.75 40 41117 4929 63442936
Dyskinesia 62.88 11.75 90 41067 31912 63415953
Feeling of body temperature change 62.02 11.75 39 41118 4858 63443007
Gastrooesophageal reflux disease 60.61 11.75 167 40990 95472 63352393
Therapeutic product effect decreased 60.07 11.75 25 41132 193162 63254703
Product dose omission issue 60.02 11.75 39 41118 234274 63213591
Abdominal discomfort 59.85 11.75 72 41085 320813 63127052
Neutropenic sepsis 59.64 11.75 63 41094 16375 63431490
Pituitary tumour benign 59.40 11.75 28 41129 1967 63445898
Menstrual disorder 59.11 11.75 39 41118 5274 63442591
Bronchopulmonary aspergillosis allergic 59.08 11.75 29 41128 2229 63445636
Rash 58.88 11.75 178 40979 560693 62887172
On and off phenomenon 58.50 11.75 27 41130 1808 63446057
Hallucinations, mixed 57.53 11.75 37 41120 4792 63443073
Pericarditis 56.13 11.75 9 41148 131570 63316295
Contraindicated product administered 56.05 11.75 36 41121 217612 63230253
Rhinalgia 55.62 11.75 25 41132 1574 63446291
Cestode infection 55.46 11.75 16 41141 271 63447594
Stoma site erythema 54.82 11.75 23 41134 1224 63446641
Mood swings 54.23 11.75 63 41094 18185 63429680
Muscle rigidity 52.63 11.75 50 41107 11450 63436415
Lung opacity 52.51 11.75 30 41127 3138 63444727
Restless legs syndrome 51.80 11.75 62 41095 18469 63429396
Parosmia 51.37 11.75 38 41119 6168 63441697
Mydriasis 50.99 11.75 50 41107 11906 63435959
Synovitis 50.81 11.75 29 41128 186889 63260976
Electrocardiogram QT prolonged 50.33 11.75 116 41041 59414 63388451
Dystonia 48.43 11.75 52 41105 13767 63434098
Serotonin syndrome 48.23 11.75 75 41082 28607 63419258
Wound 47.81 11.75 23 41134 163240 63284625
Treatment failure 47.18 11.75 36 41121 199007 63248858
Glossodynia 46.86 11.75 29 41128 178847 63269018
Stoma site discharge 46.27 11.75 22 41135 1576 63446289
Hand deformity 45.88 11.75 23 41134 159434 63288431
Infection 45.33 11.75 49 41108 229124 63218741
Folate deficiency 45.26 11.75 25 41132 2450 63445415
Hepatic enzyme increased 44.96 11.75 39 41118 202289 63245576
Psychotic disorder 44.31 11.75 68 41089 25644 63422221
Schizophrenia 43.15 11.75 42 41115 9910 63437955
Sputum discoloured 42.93 11.75 53 41104 16294 63431571
Decreased appetite 41.64 11.75 292 40865 250760 63197105
Neuroleptic malignant syndrome 41.61 11.75 45 41112 12011 63435854
Blood sodium decreased 41.60 11.75 64 41093 24188 63423677
Lung diffusion test decreased 41.51 11.75 16 41141 682 63447183
Paralysis 41.47 11.75 41 41116 9859 63438006
Discomfort 41.31 11.75 29 41128 167345 63280520
Basal ganglion degeneration 40.55 11.75 14 41143 434 63447431
Akathisia 40.41 11.75 39 41118 9107 63438758
Tissue infiltration 39.49 11.75 15 41142 614 63447251
Inguinal hernia 38.71 11.75 21 41136 1986 63445879
Exposure via breast milk 38.23 11.75 21 41136 2036 63445829
Forced vital capacity decreased 37.94 11.75 17 41140 1062 63446803
Vulvovaginal burning sensation 37.74 11.75 21 41136 2088 63445777
Premenstrual syndrome 37.54 11.75 15 41142 704 63447161
Adverse drug reaction 37.47 11.75 4 41153 79710 63368155
Poor sucking reflex 37.20 11.75 12 41145 300 63447565
Lip pruritus 36.79 11.75 16 41141 931 63446934
Magnesium deficiency 36.74 11.75 14 41143 578 63447287
Vulvovaginal pruritus 36.55 11.75 24 41133 3219 63444646
Secondary adrenocortical insufficiency 36.35 11.75 18 41139 1410 63446455
Emotional disorder 36.14 11.75 44 41113 13335 63434530
Uterine enlargement 35.32 11.75 17 41140 1251 63446614
Neurologic neglect syndrome 35.29 11.75 22 41135 2699 63445166
Paraesthesia 35.01 11.75 197 40960 156769 63291096
Hyperchlorhydria 34.75 11.75 19 41138 1825 63446040
Carotid artery thrombosis 34.75 11.75 22 41135 2772 63445093
Anti-cyclic citrullinated peptide antibody positive 34.59 11.75 16 41141 116196 63331669
Aphasia 34.40 11.75 70 41087 32930 63414935
Hallucination, auditory 34.36 11.75 42 41115 12782 63435083
Sinus congestion 34.18 11.75 50 41107 18073 63429792
Cyanosis 33.81 11.75 48 41109 16887 63430978
Tremor 33.59 11.75 172 40985 132067 63315798
Skin discolouration 33.40 11.75 75 41082 37753 63410112
Rheumatoid factor positive 33.35 11.75 7 41150 84399 63363466
Blood pressure diastolic abnormal 33.23 11.75 44 41113 14498 63433367
Aspiration 33.14 11.75 38 41119 10813 63437052
Maternal exposure during breast feeding 32.94 11.75 25 41132 4216 63443649
Genital pain 32.87 11.75 12 41145 439 63447426
Incontinence 32.64 11.75 39 41118 11593 63436272
Maternal exposure during pregnancy 32.54 11.75 58 41099 220004 63227861
Mania 32.32 11.75 40 41117 12327 63435538
Freezing phenomenon 32.28 11.75 16 41141 1256 63446609
Genital ulceration 31.91 11.75 13 41144 642 63447223
Lichen sclerosus 31.29 11.75 15 41142 1094 63446771
Unresponsive to stimuli 30.93 11.75 68 41089 33748 63414117
Abdominal tenderness 30.88 11.75 32 41125 8134 63439731
Cardiac failure congestive 30.30 11.75 11 41146 92422 63355443
Aphthous ulcer 30.06 11.75 41 41116 13897 63433968
Polymenorrhoea 29.92 11.75 15 41142 1206 63446659
Anaesthesia 29.59 11.75 11 41146 424 63447441
Drug interaction 29.35 11.75 251 40906 228880 63218985
Duodenal ulcer perforation 29.24 11.75 10 41147 87199 63360666
Nail dystrophy 29.10 11.75 14 41143 1029 63446836
Cannabinoid hyperemesis syndrome 28.94 11.75 7 41150 57 63447808
Stoma site hypergranulation 28.90 11.75 10 41147 312 63447553
Mucosal inflammation 28.78 11.75 81 41076 46847 63401018
Limbic encephalitis 28.63 11.75 10 41147 321 63447544
Abdominal pain upper 28.49 11.75 230 40927 206214 63241651
Body temperature fluctuation 28.44 11.75 18 41139 2267 63445598
Rales 28.37 11.75 38 41119 12659 63435206
Mental disorder 28.24 11.75 56 41101 25863 63422002
Constipation 28.07 11.75 245 40912 224698 63223167
Chronic sinusitis 28.03 11.75 38 41119 12805 63435060
Personality disorder 28 11.75 26 41131 5785 63442080
Paranoia 27.71 11.75 36 41121 11643 63436222
Menstruation delayed 27.66 11.75 16 41141 1713 63446152
Biliary sepsis 27.51 11.75 13 41144 918 63446947
Gastric disorder 27.47 11.75 69 41088 37300 63410565
Hemiplegia 27.39 11.75 32 41125 9291 63438574
Thyroid stimulating immunoglobulin increased 26.97 11.75 7 41150 78 63447787
Muscle injury 26.69 11.75 5 41152 65340 63382525
Obstructive airways disorder 26.61 11.75 48 41109 20651 63427214
Joint swelling 26.35 11.75 116 41041 327550 63120315
Paranasal sinus discomfort 25.91 11.75 22 41135 4354 63443511
Blood calcium increased 25.66 11.75 31 41126 9319 63438546
Injection site extravasation 25.40 11.75 30 41127 8811 63439054
Tinnitus 25.38 11.75 65 41092 35563 63412302
Subileus 25.27 11.75 19 41138 3160 63444705
Motor dysfunction 25.27 11.75 33 41124 10728 63437137
Drug withdrawal syndrome 25.23 11.75 55 41102 27139 63420726
Hypoaesthesia 25.10 11.75 191 40966 168202 63279663
Gastritis fungal 25.05 11.75 7 41150 105 63447760
Impaired healing 24.99 11.75 18 41139 102524 63345341
Hypokalaemia 24.96 11.75 133 41024 103671 63344194
Angina pectoris 24.74 11.75 58 41099 30020 63417845
Lower respiratory tract infection viral 24.61 11.75 12 41145 909 63446956
Adrenal suppression 24.57 11.75 12 41145 912 63446953
Restlessness 24.45 11.75 57 41100 29396 63418469
Neuropathy peripheral 24.24 11.75 141 41016 113526 63334339
Torsade de pointes 23.98 11.75 36 41121 13315 63434550
Feeling jittery 23.87 11.75 36 41121 13367 63434498
Injury 23.53 11.75 9 41148 73238 63374627
Hypochromic anaemia 23.43 11.75 15 41142 1927 63445938
Febrile neutropenia 23.39 11.75 144 41013 118305 63329560
Therapeutic product effect incomplete 23.34 11.75 28 41129 125028 63322837
Stoma site infection 22.96 11.75 11 41146 801 63447064
Cough 22.87 11.75 290 40867 292453 63155412
Glomerulonephritis chronic 22.76 11.75 7 41150 149 63447716
Psychogenic seizure 22.75 11.75 14 41143 1678 63446187
Vascular encephalopathy 22.33 11.75 9 41148 432 63447433
Pyrexia 22.20 11.75 428 40729 470050 62977815
Swelling 21.82 11.75 98 41059 275280 63172585
Helicobacter infection 21.69 11.75 17 41140 92768 63355097
Pulmonary function test decreased 21.66 11.75 19 41138 3928 63443937
Suicidal ideation 21.64 11.75 89 41068 62332 63385533
Stoma site inflammation 21.36 11.75 9 41148 484 63447381
Vaginal cellulitis 21.29 11.75 6 41151 93 63447772
Chest discomfort 21.28 11.75 133 41024 109836 63338029
Overdose 21.22 11.75 26 41131 115052 63332813
Psoriatic arthropathy 21.10 11.75 17 41140 91503 63356362
Injection site erythema 21.06 11.75 14 41143 83160 63364705
Dysphagia 20.95 11.75 113 41044 88472 63359393
Dementia 20.95 11.75 41 41116 18753 63429112
Hip arthroplasty 20.90 11.75 3 41154 47643 63400222
Axillary pain 20.72 11.75 14 41143 1969 63445896
Stoma site pain 20.69 11.75 11 41146 999 63446866
Knee arthroplasty 20.40 11.75 5 41152 54201 63393664
Cataract 20.30 11.75 82 41075 56971 63390894
Alopecia 20.19 11.75 132 41025 337404 63110461
Abdominal pain 20.15 11.75 284 40873 293172 63154693
Fibromyalgia 19.74 11.75 14 41143 80406 63367459
Nail bed tenderness 19.52 11.75 8 41149 401 63447464
Lung disorder 19.44 11.75 86 41071 62175 63385690
Hospitalisation 19.37 11.75 16 41141 85065 63362800
Throat irritation 19.30 11.75 61 41096 37586 63410279
Neurological decompensation 19.29 11.75 15 41142 2623 63445242
Urinary retention 19.26 11.75 53 41104 30248 63417617
Renal failure 19.25 11.75 29 41128 117623 63330242
Speech disorder 19.18 11.75 64 41093 40565 63407300
Pallor 18.97 11.75 53 41104 30515 63417350
Galactorrhoea 18.89 11.75 18 41139 4137 63443728
Monoplegia 18.76 11.75 16 41141 3185 63444680
Oral cavity fistula 18.72 11.75 9 41148 661 63447204
Heart rate increased 18.24 11.75 114 41043 94124 63353741
Migraine 18.16 11.75 122 41035 103224 63344641
Off label use 18.07 11.75 568 40589 673894 62773971
Hypomagnesaemia 18.01 11.75 50 41107 28687 63419178
Wrong technique in product usage process 17.91 11.75 9 41148 62331 63385534
Blood pressure increased 17.91 11.75 172 40985 161890 63285975
Muscle spasticity 17.90 11.75 42 41115 21752 63426113
Terminal ileitis 17.80 11.75 9 41148 737 63447128
Blood pressure systolic increased 17.57 11.75 69 41088 47328 63400537
Therapeutic response decreased 17.50 11.75 9 41148 61516 63386349
Impaired gastric emptying 17.34 11.75 27 41130 10305 63437560
Increased appetite 17.34 11.75 26 41131 9604 63438261
Gastroenteritis bacterial 16.68 11.75 7 41150 373 63447492
Autonomic neuropathy 16.64 11.75 10 41147 1149 63446716
Bronchiectasis 16.54 11.75 34 41123 16108 63431757
Carcinoid tumour 16.48 11.75 7 41150 384 63447481
Vascular access site pain 16.41 11.75 5 41152 103 63447762
Dermatitis exfoliative generalised 16.38 11.75 16 41141 3791 63444074
Adrenal insufficiency 16.35 11.75 36 41121 17879 63429986
Folliculitis 16.29 11.75 13 41144 70304 63377561
Disorientation 15.91 11.75 59 41098 39393 63408472
Anti-thyroid antibody positive 15.84 11.75 7 41150 423 63447442
Macrocytosis 15.76 11.75 13 41144 2472 63445393
Urticaria 15.67 11.75 55 41102 165747 63282118
Gastrointestinal pain 15.65 11.75 25 41132 9751 63438114
Foetal exposure timing unspecified 15.38 11.75 6 41151 264 63447601
Respiratory tract congestion 15.34 11.75 35 41122 17797 63430068
Palpitations 15.19 11.75 125 41032 112645 63335220
Heart rate decreased 15.04 11.75 64 41093 45496 63402369
External ear cellulitis 14.97 11.75 6 41151 284 63447581
Catheter site haemorrhage 14.90 11.75 14 41143 3161 63444704
Adjustment disorder 14.89 11.75 14 41143 3164 63444701
Hepatotoxicity 14.78 11.75 3 41154 37038 63410827
Blood pressure systolic abnormal 14.67 11.75 29 41128 13357 63434508
Limb injury 14.67 11.75 43 41114 25434 63422431
Neck pain 14.62 11.75 14 41143 69304 63378561
Dysaesthesia pharynx 14.54 11.75 5 41152 153 63447712
Delirium 14.43 11.75 68 41089 50473 63397392
Stoma complication 14.38 11.75 7 41150 528 63447337
Infusion site vesicles 14.31 11.75 7 41150 534 63447331
Stoma site extravasation 14.31 11.75 6 41151 319 63447546
Duodenal stenosis 14.30 11.75 7 41150 535 63447330
Swollen joint count increased 14.22 11.75 3 41154 36051 63411814
Repetitive strain injury 14.16 11.75 5 41152 166 63447699
Pre-eclampsia 14.14 11.75 23 41134 9110 63438755
Ejection fraction decreased 14.13 11.75 39 41118 22293 63425572
Bezoar 14.12 11.75 10 41147 1516 63446349
Condition aggravated 14.12 11.75 180 40977 402037 63045828
Coordination abnormal 14.10 11.75 29 41128 13744 63434121
Chronic obstructive pulmonary disease 14.01 11.75 12 41145 62674 63385191
Tardive dyskinesia 13.97 11.75 22 41135 8480 63439385
Adverse event 13.84 11.75 14 41143 67545 63380320
Blood test abnormal 13.81 11.75 31 41126 15598 63432267
Gastrointestinal sounds abnormal 13.77 11.75 15 41142 4036 63443829
Sinus disorder 13.72 11.75 41 41116 24512 63423353
Thyroxine free increased 13.66 11.75 8 41149 876 63446989
Injection site swelling 13.47 11.75 7 41150 47565 63400300
Nasal discomfort 13.42 11.75 16 41141 4744 63443121
Blood pressure systolic decreased 13.36 11.75 20 41137 7377 63440488
Injection site reaction 13.33 11.75 11 41146 58513 63389352
Hyperpyrexia 13.32 11.75 14 41143 3618 63444247
Functional residual capacity decreased 13.20 11.75 4 41153 81 63447784
Odynophagia 13.18 11.75 20 41137 7466 63440399
Vascular rupture 13.16 11.75 10 41147 1690 63446175
Toxicity to various agents 13.15 11.75 100 41057 247150 63200715
Oral herpes 13.14 11.75 42 41115 26032 63421833
Intention tremor 13.14 11.75 6 41151 392 63447473
Pseudocholinesterase deficiency 13.06 11.75 4 41153 84 63447781
Feeling abnormal 12.86 11.75 51 41106 148341 63299524
Irritable bowel syndrome 12.83 11.75 21 41136 82391 63365474
Microvillous inclusion disease 12.80 11.75 3 41154 21 63447844
Infusion related reaction 12.73 11.75 100 41057 245421 63202444
Hypothyroidism 12.64 11.75 58 41099 42574 63405291
Road traffic accident 12.63 11.75 4 41153 36628 63411237
Acute hepatic failure 12.60 11.75 33 41124 18294 63429571
Multiple organ dysfunction syndrome 12.52 11.75 11 41146 56741 63391124
Transposition of the great vessels 12.49 11.75 5 41152 236 63447629
Vision blurred 12.44 11.75 102 41055 91822 63356043
Internal haemorrhage 12.38 11.75 16 41141 5149 63442716
Injection site pustule 12.36 11.75 4 41153 101 63447764
Bradykinesia 12.32 11.75 16 41141 5172 63442693
Nasal dryness 12.27 11.75 15 41142 4566 63443299
Stoma site haemorrhage 12.25 11.75 8 41149 1063 63446802
Obesity 12.25 11.75 45 41112 29907 63417958
Sprue-like enteropathy 12.22 11.75 7 41150 736 63447129
Exposed bone in jaw 12.04 11.75 12 41145 2913 63444952
Affect lability 12.03 11.75 24 41133 11127 63436738
Needle issue 12.01 11.75 23 41134 10353 63437512
Infertility 11.89 11.75 7 41150 774 63447091
Salivary gland cancer stage IV 11.85 11.75 3 41154 30 63447835
Blood pressure diastolic decreased 11.83 11.75 37 41120 22669 63425196
Oxygen saturation decreased 11.82 11.75 98 41059 88487 63359378
Facet joint syndrome 11.77 11.75 25 41132 12113 63435752
Appendicitis 11.77 11.75 20 41137 8209 63439656
Pancreatitis chronic 11.75 11.75 11 41146 2473 63445392

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Regurgitation 78.56 13.25 28 13094 1671 34942138
On and off phenomenon 68.08 13.25 28 13094 2469 34941340
Oropharyngeal discomfort 55.20 13.25 26 13096 3170 34940639
Vitamin B12 deficiency 52.34 13.25 27 13095 4004 34939805
Eructation 51.02 13.25 28 13094 4703 34939106
Drug ineffective 40.05 13.25 69 13053 456682 34487127
Pulmonary vasculitis 39.98 13.25 13 13109 586 34943223
Intentional medical device removal by patient 39.05 13.25 11 13111 302 34943507
Stoma site discharge 37.89 13.25 15 13107 1198 34942611
Vomiting 36.31 13.25 186 12936 247435 34696374
Neuritis 34.33 13.25 13 13109 921 34942888
Dyspepsia 33.57 13.25 54 13068 36678 34907131
Oesophageal haemorrhage 33.30 13.25 14 13108 1304 34942505
Oesophagitis 32.55 13.25 32 13090 13229 34930580
Hyperkinesia 32.44 13.25 15 13107 1753 34942056
Stoma site erythema 31.81 13.25 12 13110 841 34942968
Aspiration 31.00 13.25 30 13092 12164 34931645
Saliva altered 29.67 13.25 8 13114 186 34943623
Device dislocation 29.61 13.25 22 13100 6227 34937582
Sputum increased 28.27 13.25 15 13107 2355 34941454
Akinesia 26.56 13.25 14 13108 2170 34941639
Respiratory symptom 26.14 13.25 13 13109 1784 34942025
Stoma site inflammation 26.01 13.25 9 13113 492 34943317
Freezing phenomenon 25.01 13.25 12 13110 1524 34942285
Asthma-chronic obstructive pulmonary disease overlap syndrome 23.87 13.25 11 13111 1276 34942533
Impulse-control disorder 23.75 13.25 11 13111 1290 34942519
Dyskinesia 23.33 13.25 35 13087 22378 34921431
Stoma site pain 23.27 13.25 9 13113 675 34943134
Cataract 23.24 13.25 38 13084 26148 34917661
Impaired gastric emptying 23.03 13.25 15 13107 3438 34940371
Hypomagnesaemia 22.57 13.25 34 13088 21817 34921992
Stoma site infection 21.80 13.25 9 13113 801 34943008
Lower respiratory tract infection 21.71 13.25 41 13081 31596 34912213
Colectomy total 20.79 13.25 6 13116 180 34943629
Obstructive airways disorder 20.28 13.25 27 13095 15467 34928342
Cell death 20.18 13.25 12 13110 2345 34941464
Completed suicide 20.00 13.25 6 13116 98162 34845647
Incorrect product dosage form administered 19.80 13.25 6 13116 214 34943595
Neutropenic sepsis 19.59 13.25 25 13097 13742 34930067
Pulmonary fibrosis 19.54 13.25 29 13093 18367 34925442
Dysphagia 18.99 13.25 59 13063 62322 34881487
Cerebral hypoperfusion 18.20 13.25 7 13115 517 34943292
Pulmonary alveolar haemorrhage 18.20 13.25 18 13104 7494 34936315
Gastrooesophageal reflux disease 17.71 13.25 42 13080 37882 34905927
Dystonia 17.54 13.25 21 13101 10824 34932985
Abdominal distension 17.50 13.25 55 13067 58437 34885372
Embedded device 17.39 13.25 6 13116 325 34943484
Paralysis recurrent laryngeal nerve 17.39 13.25 4 13118 47 34943762
Hypocalcaemia 17.32 13.25 32 13090 24257 34919552
Gene mutation identification test positive 17.23 13.25 5 13117 153 34943656
Dyskinesia oesophageal 16.95 13.25 4 13118 53 34943756
Bradykinesia 16.88 13.25 13 13109 3880 34939929
Blood immunoglobulin E increased 16.84 13.25 11 13111 2535 34941274
Toxicity to various agents 16.81 13.25 31 13091 200331 34743478
Electrocardiogram QT prolonged 16.63 13.25 43 13079 40909 34902900
Inappropriate antidiuretic hormone secretion 16.35 13.25 22 13100 12731 34931078
Neurological symptom 16.05 13.25 13 13109 4172 34939637
Gastric dilatation 15.91 13.25 7 13115 728 34943081
Gastroenteritis 15.72 13.25 23 13099 14377 34929432
Sleep disorder due to a general medical condition 15.49 13.25 14 13108 5207 34938602
Fanconi syndrome 15.36 13.25 9 13113 1711 34942098
Pneumonia aspiration 15.01 13.25 42 13080 41861 34901948
Lumbosacral plexus injury 14.83 13.25 3 13119 18 34943791
Bronchiectasis 14.27 13.25 18 13104 9783 34934026
Post inflammatory pigmentation change 14.13 13.25 5 13117 292 34943517
Choking 14.01 13.25 13 13109 5002 34938807
Neck pain 13.98 13.25 30 13092 25319 34918490
Skin erosion 13.77 13.25 9 13113 2076 34941733
Shock symptom 13.61 13.25 4 13118 128 34943681
Hypoosmolar state 13.61 13.25 4 13118 128 34943681

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Gastric pH decreased 122.16 11.22 38 51283 848 79692219
Derealisation 120.97 11.22 44 51277 1605 79691462
Completed suicide 115.43 11.22 12 51309 245755 79447312
Depersonalisation/derealisation disorder 108.60 11.22 42 51279 1820 79691247
Vomiting 102.77 11.22 756 50565 665072 79027995
Premature labour 102.16 11.22 65 51256 8325 79684742
On and off phenomenon 92.27 11.22 44 51277 3196 79689871
H1N1 influenza 86.67 11.22 39 51282 2480 79690587
Sensory loss 85.03 11.22 69 51252 12922 79680145
Hypoaesthesia oral 82.02 11.22 70 51251 14054 79679013
Feeling of despair 79.40 11.22 38 51283 2783 79690284
Pulmonary malformation 78.02 11.22 20 51301 213 79692854
Blepharospasm 77.96 11.22 48 51273 5803 79687264
Drug ineffective 76.84 11.22 397 50924 1080516 78612551
Cogwheel rigidity 76.13 11.22 38 51283 3050 79690017
Dissociation 72.12 11.22 40 51281 3981 79689086
Menstrual disorder 68.98 11.22 39 51282 4028 79689039
Gastrooesophageal reflux disease 67.85 11.22 183 51138 104063 79589004
Dyskinesia 67.58 11.22 111 51210 44662 79648405
Hyperprolactinaemia 66.51 11.22 40 51281 4636 79688431
Gangrene 65.94 11.22 51 51270 8913 79684154
Neutropenic sepsis 64.05 11.22 83 51238 26981 79666086
Therapeutic product ineffective 63.73 11.22 29 51292 1893 79691174
Stoma site erythema 63.06 11.22 28 51293 1725 79691342
Total lung capacity decreased 60.76 11.22 32 51289 2873 79690194
Stoma site discharge 59.88 11.22 29 51292 2180 79690887
Arterial occlusive disease 59.79 11.22 47 51274 8409 79684658
Feeling of body temperature change 59.28 11.22 39 51282 5287 79687780
Muscle disorder 59.20 11.22 40 51281 5667 79687400
Lung cyst 57.67 11.22 17 51304 314 79692753
Dystonia 57.61 11.22 70 51251 21329 79671738
Aspiration 56.00 11.22 67 51254 20091 79672976
Mood swings 53.47 11.22 65 51256 19815 79673252
Drooling 53.14 11.22 38 51283 5896 79687171
Pituitary tumour benign 52.81 11.22 28 51293 2548 79690519
Cestode infection 51.62 11.22 15 51306 263 79692804
Electrocardiogram QT prolonged 51.30 11.22 151 51170 90235 79602832
Bronchopulmonary aspergillosis allergic 50.97 11.22 29 51292 3032 79690035
Restless legs syndrome 49.72 11.22 63 51258 20029 79673038
Parosmia 49.62 11.22 39 51282 6975 79686092
Respiratory tract malformation 48.34 11.22 12 51309 111 79692956
Product dose omission issue 48.09 11.22 53 51268 247484 79445583
Taste disorder 47.97 11.22 55 51266 15768 79677299
Rhinalgia 46.48 11.22 25 51296 2342 79690725
Hallucinations, mixed 45.90 11.22 37 51284 6862 79686205
Toxicity to various agents 45.12 11.22 131 51190 421409 79271658
Pemphigus 43.91 11.22 6 51315 99576 79593491
Folate deficiency 43.33 11.22 27 51294 3333 79689734
Vulvovaginal burning sensation 43.14 11.22 21 51300 1596 79691471
Therapeutic product effect decreased 43.11 11.22 26 51295 163837 79529230
Exposure via breast milk 42.68 11.22 18 51303 978 79692089
Regurgitation 42.67 11.22 25 51296 2762 79690305
Muscle rigidity 42.47 11.22 58 51263 19824 79673243
Poor sucking reflex 42.34 11.22 11 51310 124 79692943
Obstructive airways disorder 42.19 11.22 74 51247 31385 79661682
Decreased appetite 41.80 11.22 369 50952 342049 79351018
Nightmare 41.59 11.22 66 51255 25795 79667272
Vulvovaginal pruritus 41.32 11.22 24 51297 2609 79690458
Premenstrual syndrome 41.14 11.22 15 51306 551 79692516
Skin discolouration 40.81 11.22 85 51236 40949 79652118
Systemic lupus erythematosus 39.97 11.22 14 51307 121135 79571932
Sputum discoloured 39.91 11.22 59 51262 21684 79671383
Drug abuse 39.83 11.22 28 51293 162663 79530404
Lung opacity 39.29 11.22 30 51291 5144 79687923
Epilepsy 37.59 11.22 82 51239 40778 79652289
Lip pruritus 37.48 11.22 16 51305 896 79692171
Mydriasis 36.98 11.22 51 51270 17592 79675475
Akathisia 36.72 11.22 44 51277 13215 79679852
Arthropathy 36.55 11.22 36 51285 177075 79515992
Magnesium deficiency 36.12 11.22 14 51307 610 79692457
Schizophrenia 35.98 11.22 47 51274 15393 79677674
Genital pain 35.84 11.22 15 51306 799 79692268
Synovitis 35.52 11.22 27 51294 150707 79542360
Paralysis 35.30 11.22 43 51278 13134 79679933
Hypersensitivity 34.68 11.22 73 51248 262166 79430901
Genital ulceration 34.60 11.22 16 51305 1084 79691983
Cataract 34.50 11.22 103 51218 62017 79631050
Uterine enlargement 34.27 11.22 15 51306 893 79692174
Cardiac failure congestive 34.21 11.22 25 51296 142377 79550690
Constipation 34.00 11.22 304 51017 282746 79410321
Emotional disorder 33.85 11.22 44 51277 14343 79678724
Impaired gastric emptying 33.10 11.22 37 51284 10316 79682751
Basal ganglion degeneration 33.03 11.22 12 51309 436 79692631
Lower respiratory tract infection viral 33.02 11.22 16 51305 1204 79691863
Lichen sclerosus 32.96 11.22 15 51306 979 79692088
Polymenorrhoea 32.85 11.22 15 51306 987 79692080
Stoma site infection 32.52 11.22 17 51304 1503 79691564
Hepatic enzyme increased 32.36 11.22 42 51279 182568 79510499
Serotonin syndrome 32.30 11.22 82 51239 44945 79648122
Rash 32.18 11.22 229 51092 578129 79114938
Tremor 31.93 11.22 203 51118 169880 79523187
Neurologic neglect syndrome 31.66 11.22 21 51300 2886 79690181
Freezing phenomenon 31.51 11.22 18 51303 1896 79691171
Tissue infiltration 31.33 11.22 13 51308 678 79692389
Mental disorder 31.31 11.22 65 51256 31237 79661830
Blood sodium decreased 30.88 11.22 67 51254 33188 79659879
Hallucination, auditory 30.81 11.22 51 51270 20642 79672425
Carotid artery thrombosis 30.72 11.22 21 51300 3032 79690035
Menstruation delayed 30.66 11.22 16 51305 1410 79691657
Lower respiratory tract infection 30.59 11.22 164 51157 129056 79564011
Vitamin B12 deficiency 30.53 11.22 30 51291 7211 79685856
Hyperchlorhydria 30.13 11.22 18 51303 2061 79691006
Pulmonary vasculitis 30.12 11.22 13 51308 748 79692319
Maternal exposure during breast feeding 30.04 11.22 20 51301 2765 79690302
Renal failure 30.01 11.22 52 51269 200916 79492151
Nail dystrophy 29.59 11.22 14 51307 999 79692068
Sinus congestion 29.58 11.22 49 51272 19847 79673220
Pulmonary fibrosis 29.25 11.22 78 51243 44034 79649033
Abdominal tenderness 29.08 11.22 35 51286 10559 79682508
Lung diffusion test decreased 29.03 11.22 15 51306 1295 79691772
Cannabinoid hyperemesis syndrome 28.47 11.22 7 51314 62 79693005
Treatment failure 28.41 11.22 41 51280 170445 79522622
Incontinence 28.28 11.22 40 51281 14124 79678943
Psychotic disorder 28.26 11.22 74 51247 41328 79651739
Abdominal pain upper 28.22 11.22 243 51078 223576 79469491
Hypomagnesaemia 28.18 11.22 80 51241 46831 79646236
Pericarditis 28.18 11.22 16 51305 104220 79588847
Blood pressure diastolic abnormal 28.16 11.22 47 51274 19155 79673912
Bronchiectasis 27.89 11.22 51 51270 22335 79670732
Forced vital capacity decreased 27.65 11.22 16 51305 1727 79691340
Inguinal hernia 27.58 11.22 27 51294 6461 79686606
Dysphagia 27.56 11.22 153 51168 121983 79571084
Feeling jittery 26.74 11.22 37 51284 12804 79680263
Chronic sinusitis 26.33 11.22 37 51284 12989 79680078
Secondary adrenocortical insufficiency 26.30 11.22 19 51302 2995 79690072
Thyroid stimulating immunoglobulin increased 26.25 11.22 7 51314 88 79692979
Stoma site hypergranulation 25.82 11.22 10 51311 435 79692632
Paranasal sinus discomfort 25.70 11.22 22 51299 4434 79688633
Gastric disorder 25.64 11.22 67 51254 37366 79655701
Dementia 25.60 11.22 52 51269 24607 79668460
Discomfort 25.38 11.22 26 51295 125591 79567476
Mucosal inflammation 25.24 11.22 106 51215 75474 79617593
Contraindicated product administered 25.17 11.22 39 51282 157499 79535568
Personality disorder 25.06 11.22 25 51296 6121 79686946
Adverse drug reaction 24.96 11.22 6 51315 66386 79626681
Stoma site pain 24.78 11.22 14 51307 1444 79691623
Impulse-control disorder 24.78 11.22 15 51306 1759 79691308
Akinesia 24.70 11.22 19 51302 3293 79689774
Stoma site inflammation 24.66 11.22 11 51310 685 79692382
Aphasia 24.55 11.22 76 51245 46656 79646411
Oral cavity fistula 24.50 11.22 11 51310 696 79692371
Foetal exposure timing unspecified 24.22 11.22 6 51315 55 79693012
Anaesthesia 24.18 11.22 10 51311 517 79692550
Abdominal discomfort 23.91 11.22 82 51239 250645 79442422
Neuropathy peripheral 23.70 11.22 164 51157 141141 79551926
Cyanosis 23.69 11.22 51 51270 25131 79667936
Drug withdrawal syndrome 23.64 11.22 62 51259 34656 79658411
Intentional medical device removal by patient 23.54 11.22 9 51312 378 79692689
Injection site extravasation 23.42 11.22 30 51291 9639 79683428
Hyperkinesia 23.35 11.22 17 51304 2712 79690355
Rheumatoid factor positive 23.31 11.22 5 51316 59834 79633233
Blood calcium increased 23.22 11.22 31 51290 10369 79682698
Aphthous ulcer 23.00 11.22 40 51281 16849 79676218
Hand deformity 22.76 11.22 20 51301 103899 79589168
Lung disorder 22.41 11.22 107 51214 80450 79612617
Oesophageal haemorrhage 22.29 11.22 14 51307 1753 79691314
Cough 22.09 11.22 345 50976 366444 79326623
Oropharyngeal discomfort 21.87 11.22 25 51296 7141 79685926
Tinnitus 21.37 11.22 70 51251 44263 79648804
Vaginal cellulitis 21.34 11.22 6 51315 93 79692974
Subileus 21.23 11.22 22 51299 5632 79687435
Throat irritation 20.96 11.22 66 51255 40880 79652187
Biliary sepsis 20.87 11.22 13 51308 1604 79691463
Mania 20.76 11.22 40 51281 18220 79674847
Anti-cyclic citrullinated peptide antibody positive 20.75 11.22 14 51307 83129 79609938
Hypokalaemia 20.62 11.22 161 51160 143879 79549188
Rales 20.55 11.22 42 51279 19959 79673108
Gingival pain 20.36 11.22 27 51294 8971 79684096
Body temperature fluctuation 20.35 11.22 18 51303 3789 79689278
Restlessness 20.29 11.22 71 51250 46421 79646646
Motor dysfunction 20.20 11.22 35 51286 14698 79678369
Blood pressure systolic increased 20.12 11.22 91 51230 66895 79626172
Gastrointestinal pain 19.93 11.22 28 51293 9827 79683240
Neuritis 19.87 11.22 13 51308 1745 79691322
Axillary pain 19.79 11.22 14 51307 2135 79690932
Injection site erythema 19.74 11.22 13 51308 78184 79614883
Diarrhoea 19.57 11.22 721 50600 879768 78813299
Nail bed tenderness 19.48 11.22 8 51313 406 79692661
Vascular encephalopathy 19.40 11.22 9 51312 614 79692453
Limbic encephalitis 19.33 11.22 10 51311 865 79692202
Coronary artery disease 19.25 11.22 9 51312 65465 79627602
Blood test abnormal 19.16 11.22 38 51283 17672 79675395
Paraesthesia 18.95 11.22 185 51136 176138 79516929
Glomerulonephritis chronic 18.82 11.22 7 51314 272 79692795
Psychogenic seizure 18.76 11.22 13 51308 1918 79691149
Speech disorder 18.68 11.22 77 51244 54368 79638699
Infection 18.64 11.22 86 51235 241626 79451441
Abdominal pain 18.60 11.22 353 50968 389216 79303851
Transposition of the great vessels 18.59 11.22 5 51316 65 79693002
Hemiplegia 18.57 11.22 34 51287 14905 79678162
Increased appetite 18.48 11.22 30 51291 11948 79681119
Angina pectoris 18.41 11.22 74 51247 51658 79641409
Abdominal distension 18.40 11.22 136 51185 119514 79573553
Myocardial infarction 18.39 11.22 59 51262 184070 79508997
Fanconi syndrome 18.33 11.22 15 51306 2841 79690226
Joint swelling 18.18 11.22 110 51211 288536 79404531
Injury 18.10 11.22 14 51307 77482 79615585
Saliva altered 18.03 11.22 8 51313 492 79692575
Eructation 17.76 11.22 28 51293 10881 79682186
Overdose 17.72 11.22 60 51261 184146 79508921
Wrong technique in product usage process 17.70 11.22 13 51308 73862 79619205
Nasal dryness 17.58 11.22 18 51303 4545 79688522
Adrenal suppression 17.43 11.22 11 51310 1388 79691679
Gastritis fungal 17.24 11.22 6 51315 192 79692875
Cell death 17.13 11.22 18 51303 4681 79688386
Muscle injury 17.10 11.22 5 51316 48556 79644511
Illness 16.93 11.22 67 51254 46444 79646623
Torsade de pointes 16.90 11.22 38 51283 19274 79673793
Pyrexia 16.85 11.22 563 50758 678146 79014921
Hepatotoxicity 16.82 11.22 6 51315 51346 79641721
Hypochromic anaemia 16.72 11.22 14 51307 2737 79690330
Neuroleptic malignant syndrome 16.55 11.22 47 51274 27512 79665555
Bradykinesia 16.48 11.22 23 51298 8020 79685047
Limb injury 16.43 11.22 49 51272 29479 79663588
Muscle spasticity 16.34 11.22 40 51281 21435 79671632
Oral candidiasis 16.32 11.22 49 51272 29579 79663488
Cardio-respiratory arrest 16.26 11.22 28 51293 108482 79584585
Sinus disorder 16.20 11.22 41 51280 22423 79670644
Monoplegia 15.91 11.22 16 51305 3955 79689112
Sleep disorder 15.90 11.22 102 51219 85575 79607492
Pulmonary function test decreased 15.89 11.22 22 51299 7615 79685452
Febrile neutropenia 15.74 11.22 222 51099 230777 79462290
Treatment noncompliance 15.66 11.22 7 51314 52261 79640806
Wound 15.63 11.22 32 51289 116147 79576920
Gastroenteritis bacterial 15.60 11.22 7 51314 442 79692625
Duodenal ulcer perforation 15.41 11.22 12 51309 66199 79626868
Respiratory failure 15.39 11.22 62 51259 180849 79512218
Hospitalisation 15.36 11.22 23 51298 94213 79598854
Vascular access site pain 15.35 11.22 5 51316 130 79692937
Cardiogenic shock 15.35 11.22 4 51317 41910 79651157
Drug hypersensitivity 15.32 11.22 121 51200 298795 79394272
Bradycardia 15.30 11.22 41 51280 135516 79557551
Blood pressure increased 15.16 11.22 205 51116 211155 79481912
Bone marrow failure 15.07 11.22 7 51314 51100 79641967
Intestinal dilatation 14.90 11.22 13 51308 2687 79690380
Anti-thyroid antibody positive 14.87 11.22 7 51314 494 79692573
Hypothyroidism 14.86 11.22 70 51251 52322 79640745
Psoriatic arthropathy 14.80 11.22 17 51304 77982 79615085
Oral herpes 14.75 11.22 45 51276 27409 79665658
Incorrect product dosage form administered 14.68 11.22 6 51315 301 79692766
Dopamine dysregulation syndrome 14.66 11.22 7 51314 510 79692557
Multiple organ dysfunction syndrome 14.63 11.22 35 51286 120211 79572856
Pneumothorax spontaneous 14.63 11.22 10 51311 1444 79691623
Repetitive strain injury 14.61 11.22 5 51316 152 79692915
Infusion site vesicles 14.59 11.22 7 51314 515 79692552
Paranoia 14.58 11.22 36 51285 19396 79673671
Pneumonia aspiration 14.51 11.22 83 51238 66884 79626183
Device kink 14.41 11.22 11 51310 1884 79691183
Dyskinesia oesophageal 14.35 11.22 4 51317 60 79693007
Glossodynia 14.30 11.22 28 51293 103309 79589758
Stoma complication 14.29 11.22 8 51313 811 79692256
Pallor 14.29 11.22 67 51254 49995 79643072
Oesophagitis 14.17 11.22 41 51280 24248 79668819
Heart rate increased 14.13 11.22 129 51192 120595 79572472
Respiratory tract congestion 13.96 11.22 36 51285 19918 79673149
Sequestrectomy 13.91 11.22 8 51313 854 79692213
Hip arthroplasty 13.90 11.22 3 51318 35753 79657314
Upper-airway cough syndrome 13.76 11.22 26 51295 11667 79681400
Impaired healing 13.71 11.22 22 51299 87633 79605434
Stoma site extravasation 13.68 11.22 6 51315 359 79692708
Suicidal ideation 13.63 11.22 90 51231 76250 79616817
Colectomy total 13.58 11.22 6 51315 365 79692702
Eye pain 13.57 11.22 54 51267 37524 79655543
Pyelonephritis acute 13.52 11.22 18 51303 6005 79687062
Aggression 13.51 11.22 8 51313 50950 79642117
Delirium 13.47 11.22 97 51224 84530 79608537
Terminal ileitis 13.45 11.22 8 51313 909 79692158
Respiratory symptom 13.43 11.22 16 51305 4775 79688292
Oral pain 13.39 11.22 48 51273 31750 79661317
Fibromyalgia 13.36 11.22 13 51308 64327 79628740
Deep vein thrombosis 13.33 11.22 37 51284 120882 79572185
Lumbosacral plexus injury 13.22 11.22 3 51318 18 79693049
Affect lability 13.21 11.22 25 51296 11234 79681833
Facet joint syndrome 13.14 11.22 25 51296 11277 79681790
Functional residual capacity decreased 13.13 11.22 4 51317 83 79692984
Exposed bone in jaw 13.12 11.22 14 51307 3706 79689361
Obesity 13.11 11.22 51 51270 35074 79657993
Disturbance in attention 13.07 11.22 66 51255 50735 79642332
Blood pressure diastolic decreased 13.06 11.22 46 51275 30170 79662897
Dysaesthesia pharynx 13.03 11.22 5 51316 212 79692855
Shock symptom 13.01 11.22 5 51316 213 79692854
Blood pressure systolic abnormal 12.99 11.22 32 51289 17215 79675852
Therapy cessation 12.98 11.22 4 51317 37558 79655509
Bezoar 12.97 11.22 12 51309 2676 79690391
Asthma-chronic obstructive pulmonary disease overlap syndrome 12.94 11.22 13 51308 3208 79689859
Injection site pustule 12.91 11.22 4 51317 88 79692979
Road traffic accident 12.84 11.22 6 51315 43658 79649409
Palpitations 12.71 11.22 131 51190 126479 79566588
Infertility 12.65 11.22 7 51314 694 79692373
Knee arthroplasty 12.63 11.22 6 51315 43242 79649825
International normalised ratio increased 12.57 11.22 22 51299 84699 79608368
Emotional distress 12.54 11.22 5 51316 39964 79653103
Urinary tract infection 12.49 11.22 247 51074 274265 79418802
Acute respiratory failure 12.39 11.22 12 51309 59529 79633538
Hypotension 12.39 11.22 204 51117 440113 79252954
Craniocerebral injury 12.39 11.22 16 51305 5180 79687887
Joint dislocation 12.30 11.22 31 51290 16908 79676159
Stoma site haemorrhage 12.17 11.22 10 51311 1906 79691161
Urinary retention 12.14 11.22 70 51251 56560 79636507
Dyspepsia 12.14 11.22 115 51206 108572 79584495
Lip dry 12.03 11.22 29 51292 15389 79677678
Adrenal insufficiency 12.00 11.22 43 51278 28444 79664623
Angioedema 11.97 11.22 19 51302 76016 79617051
Duodenal stenosis 11.89 11.22 7 51314 780 79692287
Food poisoning 11.87 11.22 15 51306 4754 79688313
External ear cellulitis 11.78 11.22 5 51316 276 79692791
Nasal discomfort 11.72 11.22 16 51305 5467 79687600
Folliculitis 11.72 11.22 11 51310 55369 79637698
Vulvovaginal candidiasis 11.70 11.22 11 51310 2503 79690564
Gambling disorder 11.68 11.22 10 51311 2016 79691051
Injection site swelling 11.68 11.22 8 51313 47124 79645943
Hypoaesthesia 11.67 11.22 171 51150 179181 79513886
Plethysmography 11.61 11.22 3 51318 33 79693034
Galactorrhoea 11.60 11.22 13 51308 3633 79689434
Acute respiratory distress syndrome 11.57 11.22 7 51314 44060 79649007
Respiratory arrest 11.52 11.22 12 51309 57538 79635529
Endometrial thickening 11.51 11.22 5 51316 292 79692775
Onychoclasis 11.50 11.22 16 51305 5562 79687505
Injection site reaction 11.45 11.22 11 51310 54774 79638293
Sinus bradycardia 11.40 11.22 39 51282 25208 79667859
Paralysis recurrent laryngeal nerve 11.35 11.22 4 51317 133 79692934
Unresponsive to stimuli 11.34 11.22 68 51253 55720 79637347
Thyroxine free increased 11.29 11.22 8 51313 1224 79691843
Carcinoid tumour 11.27 11.22 6 51315 551 79692516

FDA Adverse Event Reporting System (Pediatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Generalised tonic-clonic seizure 47.22 24.38 9 7 131 89645

Pharmacologic Action:

SourceCodeDescription
ATC A03FA03 ALIMENTARY TRACT AND METABOLISM
DRUGS FOR FUNCTIONAL GASTROINTESTINAL DISORDERS
PROPULSIVES
Propulsives
MeSH PA D000932 Antiemetics
MeSH PA D002491 Central Nervous System Agents
MeSH PA D015259 Dopamine Agents
MeSH PA D018492 Dopamine Antagonists
MeSH PA D005765 Gastrointestinal Agents
MeSH PA D018377 Neurotransmitter Agents
MeSH PA D018373 Peripheral Nervous System Agents
CHEBI has role CHEBI:48561 dopaminergic antagonists
CHEBI has role CHEBI:50919 antiemetico

Drug Use | Suggest Off label Use Form| |View source of the data|

DiseaseRelationSNOMED_IDDOID
Nausea and vomiting indication 16932000
Acute gastric ulcer with perforation contraindication 19850005
Torsades de pointes contraindication 31722008
Acute nephropathy contraindication 58574008
Acute gastric ulcer with hemorrhage contraindication 89748001
Prolonged QT interval contraindication 111975006
Gastrointestinal obstruction contraindication 126765001
Disease of liver contraindication 235856003 DOID:409
Pregnancy, function contraindication 289908002
Congenital long QT syndrome contraindication 442917000
Pituitary Prolactinoma contraindication




🐶 Veterinary Drug Use

SpeciesUseRelation
Horses Prevention of fescue toxicosis in periparturient mares Indication

🐶 Veterinary products

ProductApplicantIngredients
Equidone Gel Dechra, Ltd. 1

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 9.45 acidic
pKa2 10.04 acidic
pKa3 7.79 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])		Mechanism
action		Bioact sourceMoA source
D(2) dopamine receptor GPCR ANTAGONIST Ki 8.40 IUPHAR IUPHAR
Alpha-2A adrenergic receptor GPCR Ki 5.99 DRUG MATRIX
Potassium voltage-gated channel subfamily H member 2 Ion channel IC50 6.79 WOMBAT-PK
Multidrug resistance protein 1 Transporter WOMBAT-PK
Sodium-dependent serotonin transporter Transporter Ki 5.79 DRUG MATRIX
Sodium-dependent noradrenaline transporter Transporter Ki 5.59 DRUG MATRIX
5-hydroxytryptamine receptor 2A GPCR Ki 7.96 DRUG MATRIX
5-hydroxytryptamine receptor 2B GPCR Ki 5.78 DRUG MATRIX
5-hydroxytryptamine receptor 2C GPCR Ki 6.16 DRUG MATRIX
Alpha-1A adrenergic receptor GPCR Ki 6.65 WOMBAT-PK
Alpha-2B adrenergic receptor GPCR Ki 6.01 DRUG MATRIX
D(3) dopamine receptor GPCR Ki 8.46 CHEMBL
Histamine H1 receptor GPCR Ki 6.81 DRUG MATRIX
Aldehyde oxidase Enzyme IC50 5.52 WOMBAT-PK
Alpha-2C adrenergic receptor GPCR Ki 6.83 DRUG MATRIX
Cytochrome P450 2D6 Enzyme Ki 5.10 WOMBAT-PK
Alpha-1D adrenergic receptor GPCR Ki 6.94 DRUG MATRIX
Alpha-1B adrenergic receptor GPCR Ki 6.28 WOMBAT-PK
Kappa-type opioid receptor GPCR Ki 5.55 DRUG MATRIX
Calmodulin Cytosolic other WOMBAT-PK
Retinoic acid receptor RXR-alpha Nuclear hormone receptor Kd 5.06 CHEMBL
Solute carrier family 22 member 2 Transporter IC50 5.10 CHEMBL
Multidrug and toxin extrusion protein 1 Transporter IC50 5.64 CHEMBL
Mu-type opioid receptor GPCR Ki 5.77 DRUG MATRIX
Multidrug and toxin extrusion protein 2 Transporter IC50 4.83 CHEMBL
Alpha-1B adrenergic receptor GPCR Ki 7.06 DRUG MATRIX
Alpha-1A adrenergic receptor GPCR IC50 6.55 CHEMBL
D(2) dopamine receptor GPCR Ki 9.28 CHEMBL
D(3) dopamine receptor GPCR Ki 7.93 CHEMBL

External reference:

IDSource
4025225 VUID
N0000171760 NUI
D01745 KEGG_DRUG
4025225 VANDF
C0013015 UMLSCUI
CHEBI:31515 CHEBI
CHEMBL219916 ChEMBL_ID
D004294 MESH_DESCRIPTOR_UI
DB01184 DRUGBANK_ID
3151 PUBCHEM_CID
965 IUPHAR_LIGAND_ID
4110 INN_ID
83898-65-1 SECONDARY_CAS_RN
5587267Z69 UNII
203007 RXNORM
003454 NDDF
005091 NDDF
32955006 SNOMEDCT_US
384972001 SNOMEDCT_US
387181004 SNOMEDCT_US

Pharmaceutical products:

None