vintafolide 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |
| Stem definition | Drug id | CAS RN |
|---|---|---|
| vinca alkaloids | 4831 | 742092-03-1 |
Description:
| Molecule | Description |
|---|---|
|
Synonyms:
|
has significant antiproliferative activity and tolerability, thus lending support to an ongoing phase 1 trial for the treatment of advanced malignancies
|
Drug dosage:
None
ADMET properties:
None
Approvals:
None
FDA Adverse Event Reporting System (Female)
None
FDA Adverse Event Reporting System (Male)
None
FDA Adverse Event Reporting System (Geriatric)
None
FDA Adverse Event Reporting System (Pediatric)
None
Pharmacologic Action:
| Source | Code | Description |
|---|---|---|
| ATC | L01CA06 | ANTINEOPLASTIC AND IMMUNOMODULATING AGENTS ANTINEOPLASTIC AGENTS PLANT ALKALOIDS AND OTHER NATURAL PRODUCTS Vinca alkaloids and analogues |
Drug Use | Suggest Off label Use Form| |View source of the data|
| Disease | Relation | SNOMED_ID | DOID |
|---|---|---|---|
| Malignant epithelial tumor of ovary | indication | 254849005 |
🐶 Veterinary Drug Use
None
🐶 Veterinary products
None
Acid dissociation constants calculated using MoKa v3.0.0
| Dissociation level | Dissociation constant | Type (acidic/basic) |
|---|---|---|
| pKa1 | 2.83 | acidic |
| pKa2 | 3.16 | acidic |
| pKa3 | 3.61 | acidic |
| pKa4 | 3.93 | acidic |
| pKa5 | 4.65 | acidic |
| pKa6 | 8.29 | acidic |
| pKa7 | 12.85 | acidic |
| pKa8 | 13.08 | acidic |
| pKa9 | 13.33 | acidic |
| pKa10 | 13.52 | acidic |
| pKa11 | 13.79 | acidic |
| pKa12 | 13.81 | acidic |
| pKa13 | 10.75 | Basic |
| pKa14 | 7.38 | Basic |
| pKa15 | 6.76 | Basic |
| pKa16 | 5.31 | Basic |
| pKa17 | 4.44 | Basic |
| pKa18 | 4.21 | Basic |
| pKa19 | 2.14 | Basic |
| pKa20 | 1.73 | Basic |
Orange Book patent data (new drug applications)
None
Orange Book exclusivity data (new drug applications)
None
Bioactivity Summary:
None
External reference:
| ID | Source |
|---|---|
| 36O410ZD4I | UNII |
| D10434 | KEGG_DRUG |
| C3530172 | UMLSCUI |
| CHEBI:134736 | CHEBI |
| CHEMBL3039521 | ChEMBL_ID |
| DB05168 | DRUGBANK_ID |
| 9564 | INN_ID |
| C520389 | MESH_SUPPLEMENTAL_RECORD_UI |
| 25014653 | PUBCHEM_CID |
Pharmaceutical products:
None